Skip Nav Destination

Issues

Select Decade

Select Year

Issue

Search within issue:

Search within issue

Lilly Lecture 2005

Adipose Tissue: From Lipid Storage Compartment to Endocrine Organ

Philipp E. Scherer

Abstracts

View articletitled, Adipose Tissue: From Lipid Storage Compartment to Endocrine Organ

Open the PDF for in another window

Topics: adipocytes , adipokines , adiponectin , adipose tissue , mice

Diabetes June 2006, Vol.55, 1537-1545. doi:https://doi.org/10.2337/db06-0263

Metabolism

Reversal of Type 1 Diabetes by Engineering a Glucose Sensor in Skeletal Muscle

Alex Mas; Joel Montané; Xavier M. Anguela; Sergio Muñoz; Anne M. Douar; Efren Riu; Pedro Otaegui; Fatima Bosch

Abstracts

View articletitled, Reversal of Type 1 Diabetes by Engineering a Glucose Sensor in Skeletal Muscle

Open the PDF for in another window

Topics: diabetes mellitus, type 1 , glucokinase , glucose , hyperglycemia , insulin

Diabetes June 2006, Vol.55, 1546-1553. doi:https://doi.org/10.2337/db05-1615

Inhibition of Fructose 1,6-Bisphosphatase Reduces Excessive Endogenous Glucose Production and Attenuates Hyperglycemia in Zucker Diabetic Fatty Rats

Paul D. van Poelje; Scott C. Potter; Visvanathan C. Chandramouli; Bernard R. Landau; Qun Dang; Mark D. Erion

Abstracts

View articletitled, Inhibition of Fructose 1,6-Bisphosphatase Reduces Excessive Endogenous Glucose Production and Attenuates Hyperglycemia in Zucker Diabetic Fatty Rats

Open the PDF for in another window

Topics: glucose , rats , triglycerides , insulin , lactates

Diabetes June 2006, Vol.55, 1747-1754. doi:https://doi.org/10.2337/db05-1443

Activation of AMP-Activated Protein Kinase Within the Ventromedial Hypothalamus Amplifies Counterregulatory Hormone Responses in Rats With Defective Counterregulation

Rory J. McCrimmon; Xiaoning Fan; Haiying Cheng; Ewan McNay; Owen Chan; Margaret Shaw; Yuyan Ding; Wanling Zhu; Robert S. Sherwin

Abstracts

View articletitled, Activation of AMP-Activated Protein Kinase Within the Ventromedial Hypothalamus Amplifies Counterregulatory Hormone Responses in Rats With Defective Counterregulation

Open the PDF for in another window

Topics: aica ribonucleotide , glucose , hypoglycemia , hypothalamus , protein kinase

Diabetes June 2006, Vol.55, 1755-1760. doi:https://doi.org/10.2337/db05-1359

Time-Dependent Effects of Free Fatty Acids on Glucose Effectiveness in Type 2 Diabetes

Preeti Kishore; Julia Tonelli; Sudha Koppaka; Corina Fratila; Anita Bose; Do-Eun Lee; Kalpana Reddy; Meredith Hawkins

Abstracts

View articletitled, Time-Dependent Effects of Free Fatty Acids on Glucose Effectiveness in Type 2 Diabetes

Open the PDF for in another window

Topics: diabetes mellitus, type 2 , glucose , hyperglycemia , infusion procedures , nonesterified fatty acids

Diabetes June 2006, Vol.55, 1761-1768. doi:https://doi.org/10.2337/db05-0988

Reduced Access to Insulin-Sensitive Tissues in Dogs With Obesity Secondary to Increased Fat Intake

Martin Ellmerer; Marianthe Hamilton-Wessler; Stella P. Kim; Katrin Huecking; Erlinda Kirkman; Jenny Chiu; Joyce Richey; Richard N. Bergman

Abstracts

View articletitled, Reduced Access to Insulin-Sensitive Tissues in Dogs With Obesity Secondary to Increased Fat Intake

Open the PDF for in another window

Topics: diet , diet, high-fat , dog, domestic , insulin , insulin resistance

Diabetes June 2006, Vol.55, 1769-1775. doi:https://doi.org/10.2337/db05-1509

Obesity Studies

Increased Infiltration of Macrophages in Omental Adipose Tissue Is Associated With Marked Hepatic Lesions in Morbid Human Obesity

Raffaella Cancello; Joan Tordjman; Christine Poitou; Gaël Guilhem; Jean Luc Bouillot; Danielle Hugol; Christiane Coussieu; Arnaud Basdevant; Avner Bar Hen; Pierre Bedossa; Michèle Guerre-Millo; Karine Clément

Abstracts

View articletitled, Increased Infiltration of Macrophages in Omental Adipose Tissue Is Associated With Marked Hepatic Lesions in Morbid Human Obesity

Open the PDF for in another window

Topics: hepatic lesions , macrophages , obesity , omentum , triglycerides

Diabetes June 2006, Vol.55, 1554-1561. doi:https://doi.org/10.2337/db06-0133

Downregulation of Electron Transport Chain Genes in Visceral Adipose Tissue in Type 2 Diabetes Independent of Obesity and Possibly Involving Tumor Necrosis Factor-α

Ingrid Dahlman; Margaretha Forsgren; Annelie Sjögren; Elisabet Arvidsson Nordström; Maria Kaaman; Erik Näslund; Anneli Attersand; Peter Arner

Abstract

View articletitled, Downregulation of Electron Transport Chain Genes in Visceral Adipose Tissue in Type 2 Diabetes Independent of Obesity and Possibly Involving Tumor Necrosis Factor-α

Open the PDF for in another window

Topics: adipose tissue , diabetes mellitus, type 2 , electron transport , genes , obesity

Diabetes June 2006, Vol.55, 1792-1799. doi:https://doi.org/10.2337/db05-1421

Immunology and Transplantation

Lymphocytic Infiltration and Immune Activation in Metallothionein Promoter–Exendin-4 (MT-Exendin) Transgenic Mice

Laurie L. Baggio; Dianne Holland; Joan Wither; Daniel J. Drucker

Abstracts

View articletitled, Lymphocytic Infiltration and Immune Activation in Metallothionein Promoter–Exendin-4 (MT-Exendin) Transgenic Mice

Supplementary data

Open the PDF for in another window

Topics: antibodies , glucagon-like peptide 1 , lymphocytes , mice , mice, transgenic

Diabetes June 2006, Vol.55, 1562-1570. doi:https://doi.org/10.2337/db05-1502

Induction of Tolerance in Type 1 Diabetes via Both CD4⁺CD25⁺ T Regulatory Cells and T Regulatory Type 1 Cells

Manuela Battaglia; Angela Stabilini; Elena Draghici; Barbara Migliavacca; Silvia Gregori; Ezio Bonifacio; Maria-Grazia Roncarolo

Abstracts

View articletitled, Induction of Tolerance in Type 1 Diabetes via Both CD4+CD25+ T Regulatory Cells and T Regulatory Type 1 Cells

Open the PDF for in another window

Topics: antigens, cd25 , interleukin-10 , mice , mice, inbred nod , pancreas

Diabetes June 2006, Vol.55, 1571-1580. doi:https://doi.org/10.2337/db05-1576

Islet Studies

Glucose Regulates Foxo1 Through Insulin Receptor Signaling in the Pancreatic Islet β-cell

Sara C. Martinez; Corentin Cras-Méneur; Ernesto Bernal-Mizrachi; M. Alan Permutt

Abstracts

View articletitled, Glucose Regulates Foxo1 Through Insulin Receptor Signaling in the Pancreatic Islet β-cell

Supplementary data

Open the PDF for in another window

Topics: forkhead box protein o1 , glucose , insulin receptor , phosphorylation , starvation

Diabetes June 2006, Vol.55, 1581-1591. doi:https://doi.org/10.2337/db05-0678

Metallothionein and Catalase Sensitize to Diabetes in Nonobese Diabetic Mice: Reactive Oxygen Species May Have a Protective Role in Pancreatic β-Cells

Xiaoyan Li; Hainan Chen; Paul N. Epstein

Abstracts

View articletitled, Metallothionein and Catalase Sensitize to Diabetes in Nonobese Diabetic Mice: Reactive Oxygen Species May Have a Protective Role in Pancreatic β-Cells

Supplementary data

Open the PDF for in another window

Topics: animals, transgenic , antioxidants , catalase , cytokine , mice

Diabetes June 2006, Vol.55, 1592-1604. doi:https://doi.org/10.2337/db05-1357

Peroxisome Proliferator–Activated Receptor α Improves Pancreatic Adaptation to Insulin Resistance in Obese Mice and Reduces Lipotoxicity in Human Islets

Fanny Lalloyer; Brigitte Vandewalle; Frédéric Percevault; Gérard Torpier; Julie Kerr-Conte; Maaike Oosterveer; Réjane Paumelle; Jean-Charles Fruchart; Folkert Kuipers; François Pattou; Catherine Fiévet; Bart Staels

Abstracts

View articletitled, Peroxisome Proliferator–Activated Receptor α Improves Pancreatic Adaptation to Insulin Resistance in Obese Mice and Reduces Lipotoxicity in Human Islets

Supplementary data

Open the PDF for in another window

Topics: mice , pancreas , ppar alpha , insulin , insulin resistance

Diabetes June 2006, Vol.55, 1605-1613. doi:https://doi.org/10.2337/db06-0016

The Role of Phosphoinositide 3-Kinase/Akt Signaling in Low-Dose Mercury–Induced Mouse Pancreatic β-Cell Dysfunction In Vitro and In Vivo

Ya Wen Chen; Chun Fa Huang; Keh Sung Tsai; Rong Sen Yang; Cheng Chieh Yen; Ching Yao Yang; Shoei Yn Lin-Shiau; Shing Hwa Liu

Abstracts

View articletitled, The Role of Phosphoinositide 3-Kinase/Akt Signaling in Low-Dose Mercury–Induced Mouse Pancreatic β-Cell Dysfunction In Vitro and In Vivo

Open the PDF for in another window

Topics: insulin secretion , mercury , mice , phosphoinositide 3-kinase , proto-oncogene proteins c-akt

Diabetes June 2006, Vol.55, 1614-1624. doi:https://doi.org/10.2337/db06-0029

Pathophysiology

Islet Inflammation and Fibrosis in a Spontaneous Model of Type 2 Diabetes, the GK Rat

Françoise Homo-Delarche; Sophie Calderari; Jean-Claude Irminger; Marie-Noëlle Gangnerau; Josiane Coulaud; Katharina Rickenbach; Manuel Dolz; Philippe Halban; Bernard Portha; Patricia Serradas

Abstracts

View articletitled, Islet Inflammation and Fibrosis in a Spontaneous Model of Type 2 Diabetes, the GK Rat

Open the PDF for in another window

Topics: diabetes mellitus, type 2 , fibrosis , gene expression , hyperglycemia , inflammation

Diabetes June 2006, Vol.55, 1625-1633. doi:https://doi.org/10.2337/db05-1526

Nutritional Supplementation With trans-10, cis-12–Conjugated Linoleic Acid Induces Inflammation of White Adipose Tissue

Hélène Poirier; Jennifer S. Shapiro; Roy J. Kim; Mitchell A. Lazar

Abstracts

View articletitled, Nutritional Supplementation With trans-10, cis-12–Conjugated Linoleic Acid Induces Inflammation of White Adipose Tissue

Open the PDF for in another window

Topics: gene expression , inflammation , insulin , interleukin-6 , linoleic acid

Diabetes June 2006, Vol.55, 1634-1641. doi:https://doi.org/10.2337/db06-0036

Cognitive Performance, Psychological Well-Being, and Brain Magnetic Resonance Imaging in Older Patients With Type 1 Diabetes

Augustina M.A. Brands; Roy P.C. Kessels; Roel P.L.M. Hoogma; Johanna M.L. Henselmans; Johanna W. van der Beek Boter; L. Jaap Kappelle; Edward H.F. de Haan; Geert Jan Biessels

Abstracts

View articletitled, Cognitive Performance, Psychological Well-Being, and Brain Magnetic Resonance Imaging in Older Patients With Type 1 Diabetes

Open the PDF for in another window

Topics: brain mri , cognitive ability , diabetes mellitus, type 1 , magnetic resonance imaging , older adult

Diabetes June 2006, Vol.55, 1800-1806. doi:https://doi.org/10.2337/db05-1226

Hyperglycemia Stimulates Coagulation, Whereas Hyperinsulinemia Impairs Fibrinolysis in Healthy Humans

Michiel E. Stegenga; Saskia N. van der Crabben; Marcel Levi; Alex F. de Vos; Michael W. Tanck; Hans P. Sauerwein; Tom van der Poll

Abstract

View articletitled, Hyperglycemia Stimulates Coagulation, Whereas Hyperinsulinemia Impairs Fibrinolysis in Healthy Humans

Open the PDF for in another window

Topics: blood coagulation , coagulation process , fibrinolysis , glucagon measurement , glucose

Diabetes June 2006, Vol.55, 1807-1812. doi:https://doi.org/10.2337/db05-1543

Decreased Muscle Strength and Quality in Older Adults With Type 2 Diabetes: The Health, Aging, and Body Composition Study

Seok Won Park; Bret H. Goodpaster; Elsa S. Strotmeyer; Nathalie de Rekeneire; Tamara B. Harris; Ann V. Schwartz; Frances A. Tylavsky; Anne B. Newman

Abstracts

View articletitled, Decreased Muscle Strength and Quality in Older Adults With Type 2 Diabetes: The Health, Aging, and Body Composition Study

Open the PDF for in another window

Topics: aging , arm , body composition , diabetes mellitus, type 2 , leg

Diabetes June 2006, Vol.55, 1813-1818. doi:https://doi.org/10.2337/db05-1183

The Intrauterine Environment as Reflected by Birth Size and Twin and Zygosity Status Influences Insulin Action and Intracellular Glucose Metabolism in an Age- or Time-Dependent Manner

Pernille Poulsen; Allan Vaag

Abstracts

View articletitled, The Intrauterine Environment as Reflected by Birth Size and Twin and Zygosity Status Influences Insulin Action and Intracellular Glucose Metabolism in an Age- or Time-Dependent Manner

Open the PDF for in another window

Topics: birth weight , glucose , insulin , twins , older adult

Diabetes June 2006, Vol.55, 1819-1825. doi:https://doi.org/10.2337/db05-1462

Complications

Deletion of p66^Shc Longevity Gene Protects Against Experimental Diabetic Glomerulopathy by Preventing Diabetes-Induced Oxidative Stress

Stefano Menini; Lorena Amadio; Giovanna Oddi; Carlo Ricci; Carlo Pesce; Francesco Pugliese; Marco Giorgio; Enrica Migliaccio; PierGiuseppe Pelicci; Carla Iacobini; Giuseppe Pugliese

Abstracts

View articletitled, Deletion of p66Shc Longevity Gene Protects Against Experimental Diabetic Glomerulopathy by Preventing Diabetes-Induced Oxidative Stress

Supplementary data

Open the PDF for in another window

Topics: kidney , mesangial cells , mice , nodular glomerulosclerosis , oxidative stress

Diabetes June 2006, Vol.55, 1642-1650. doi:https://doi.org/10.2337/db05-1477

Altered Endothelial Nitric Oxide Synthase Targeting and Conformation and Caveolin-1 Expression in the Diabetic Kidney

Radko Komers; William E. Schutzer; John F. Reed; Jessie N. Lindsley; Terry T. Oyama; David C. Buck; Scott L. Mader; Sharon Anderson

Abstracts

View articletitled, Altered Endothelial Nitric Oxide Synthase Targeting and Conformation and Caveolin-1 Expression in the Diabetic Kidney

Open the PDF for in another window

Topics: kidney , nitric oxide synthase , rats , tissue membrane , insulin

Diabetes June 2006, Vol.55, 1651-1659. doi:https://doi.org/10.2337/db05-1595

Apoptosis Signal-Regulating Kinase 1 Mediates Cellular Senescence Induced by High Glucose in Endothelial Cells

Toyohiko Yokoi; Keisuke Fukuo; Osamu Yasuda; Mizuo Hotta; Junichi Miyazaki; Yukihiro Takemura; Hidenobu Kawamoto; Hidenori Ichijo; Toshio Ogihara

Abstract

View articletitled, Apoptosis Signal-Regulating Kinase 1 Mediates Cellular Senescence Induced by High Glucose in Endothelial Cells

Open the PDF for in another window

Topics: aging , endothelial cells , glucose , older adult , phosphotransferases

Diabetes June 2006, Vol.55, 1660-1665. doi:https://doi.org/10.2337/db05-1607

Thiazolidinediones Ameliorate Diabetic Nephropathy via Cell Cycle–Dependent Mechanisms

Tatsuo Okada; Jun Wada; Kazuyuki Hida; Jun Eguchi; Izumi Hashimoto; Masako Baba; Akihiro Yasuhara; Kenichi Shikata; Hirofumi Makino

Abstract

View articletitled, Thiazolidinediones Ameliorate Diabetic Nephropathy via Cell Cycle–Dependent Mechanisms

Open the PDF for in another window

Topics: kidney glomerulus , pioglitazone , rats, inbred oletf , glucose , peroxisome proliferator-activated receptors

Diabetes June 2006, Vol.55, 1666-1677. doi:https://doi.org/10.2337/db05-1285

Salutary Effect of Pigment Epithelium–Derived Factor in Diabetic Nephropathy: Evidence for Antifibrogenic Activities

Joshua J. Wang; Sarah X. Zhang; Robert Mott; Ryan R. Knapp; Wei Cao; Kai Lau; Jian-xing Ma

Abstracts

View articletitled, Salutary Effect of Pigment Epithelium–Derived Factor in Diabetic Nephropathy: Evidence for Antifibrogenic Activities

Open the PDF for in another window

Topics: connective tissue growth factor , diabetic nephropathy , enzyme-linked immunosorbent assay , fibronectins , genes

Diabetes June 2006, Vol.55, 1678-1685. doi:https://doi.org/10.2337/db05-1448

Poly(ADP-Ribose) Polymerase Inhibition Alleviates Experimental Diabetic Sensory Neuropathy

Olga Ilnytska; Valeriy V. Lyzogubov; Martin J. Stevens; Viktor R. Drel; Nazar Mashtalir; Pal Pacher; Mark A. Yorek; Irina G. Obrosova

Abstract

View articletitled, Poly(ADP-Ribose) Polymerase Inhibition Alleviates Experimental Diabetic Sensory Neuropathy

Open the PDF for in another window

Topics: 3-nitrotyrosine , adenosine diphosphate ribose , formaldehyde , ganglia, spinal , international organization for standardization

Diabetes June 2006, Vol.55, 1686-1694. doi:https://doi.org/10.2337/db06-0067

Diabetic Nephropathy Is Associated With Gene Expression Levels of Oxidative Phosphorylation and Related Pathways

Chunmei Huang; Youngki Kim; M. Luiza Caramori; Jason H. Moore; Stephen S. Rich; Josyf C. Mychaleckyj; Paul C. Walker; Michael Mauer

Abstracts

View articletitled, Diabetic Nephropathy Is Associated With Gene Expression Levels of Oxidative Phosphorylation and Related Pathways

Open the PDF for in another window

Topics: diabetic nephropathy , gene expression , genes , oxidative phosphorylation , glucose

Diabetes June 2006, Vol.55, 1826-1831. doi:https://doi.org/10.2337/db05-1438

Risk Factors for Renal Dysfunction in Type 2 Diabetes: U.K. Prospective Diabetes Study 74

Ravi Retnakaran; Carole A. Cull; Kerensa I. Thorne; Amanda I. Adler; Rury R. Holman; for the UKPDS Study Group

Abstracts

View articletitled, Risk Factors for Renal Dysfunction in Type 2 Diabetes: U.K. Prospective Diabetes Study 74

Open the PDF for in another window

Topics: albumins , albuminuria , cardiovascular diseases , creatinine , creatinine clearance

Diabetes June 2006, Vol.55, 1832-1839. doi:https://doi.org/10.2337/db05-1620

Adiponectin Suppression of High-Glucose–Induced Reactive Oxygen Species in Vascular Endothelial Cells: Evidence for Involvement of a cAMP Signaling Pathway

Raogo Ouedraogo; Xiangdong Wu; Shi-Qiong Xu; Lauren Fuchsel; Hiroyuki Motoshima; Kalyankar Mahadev; Kelly Hough; Rosario Scalia; Barry J. Goldstein

Abstracts

View articletitled, Adiponectin Suppression of High-Glucose–Induced Reactive Oxygen Species in Vascular Endothelial Cells: Evidence for Involvement of a cAMP Signaling Pathway

Open the PDF for in another window

Topics: adiponectin , cyclic amp , generalized anxiety disorder , glucose , hydrogen peroxide

Diabetes June 2006, Vol.55, 1840-1846. doi:https://doi.org/10.2337/db05-1174

Gene Transfer of an Engineered Transcription Factor Promoting Expression of VEGF-A Protects Against Experimental Diabetic Neuropathy

Sally A. Price; Carolyn Dent; Beatriz Duran-Jimenez; Yuxin Liang; Lei Zhang; Edward J. Rebar; Casey C. Case; Philip D. Gregory; Tyler J. Martin; S. Kaye Spratt; David R. Tomlinson

Abstracts

View articletitled, Gene Transfer of an Engineered Transcription Factor Promoting Expression of VEGF-A Protects Against Experimental Diabetic Neuropathy

Open the PDF for in another window

Topics: vascular endothelial growth factor a , gene transfer techniques , transcription factor , streptozocin , diabetic neuropathies

Diabetes June 2006, Vol.55, 1847-1854. doi:https://doi.org/10.2337/db05-1060

Pharmacology & Therapeutics

Chronic Inhibition of Dipeptidyl Peptidase-4 With a Sitagliptin Analog Preserves Pancreatic β-Cell Mass and Function in a Rodent Model of Type 2 Diabetes

James Mu; John Woods; Yun-Ping Zhou; Ranabir Sinha Roy; Zhihua Li; Emanuel Zycband; Yue Feng; Lan Zhu; Cai Li; Andrew D. Howard; David. E. Moller; Nancy A. Thornberry; Bei B. Zhang

Abstracts

View articletitled, Chronic Inhibition of Dipeptidyl Peptidase-4 With a Sitagliptin Analog Preserves Pancreatic β-Cell Mass and Function in a Rodent Model of Type 2 Diabetes

Open the PDF for in another window

Topics: diabetes mellitus, type 2 , dipeptidyl-peptidase iv , dipeptidyl-peptidase iv inhibitors , glipizide , glucose

Diabetes June 2006, Vol.55, 1695-1704. doi:https://doi.org/10.2337/db05-1602

The Experimental Type 2 Diabetes Therapy Glycogen Phosphorylase Inhibition Can Impair Aerobic Muscle Function During Prolonged Contraction

David J. Baker; Paul L. Greenhaff; Alan MacInnes; James A. Timmons

Abstracts

View articletitled, The Experimental Type 2 Diabetes Therapy Glycogen Phosphorylase Inhibition Can Impair Aerobic Muscle Function During Prolonged Contraction

Open the PDF for in another window

Topics: diabetes mellitus, type 2 , fatigue , glucose-6-phosphate isomerase , glycogen phosphorylase , glycosylphosphatidylinositols

Diabetes June 2006, Vol.55, 1855-1861. doi:https://doi.org/10.2337/db05-1687

Genetics

Mutations at the Same Residue (R50) of Kir6.2 (KCNJ11) That Cause Neonatal Diabetes Produce Different Functional Effects

Kenju Shimomura; Christophe A.J. Girard; Peter Proks; Joanna Nazim; Jonathan D. Lippiat; Franco Cerutti; Renata Lorini; Sian Ellard; Andrew T. Hattersley; Fabrizio Barbetti; Frances M. Ashcroft

Abstracts

View articletitled, Mutations at the Same Residue (R50) of Kir6.2 (KCNJ11) That Cause Neonatal Diabetes Produce Different Functional Effects

Open the PDF for in another window

Topics: mutation , neonatal diabetes mellitus , tolbutamide , abcc8 gene , oocytes

Diabetes June 2006, Vol.55, 1705-1712. doi:https://doi.org/10.2337/db05-1640

From Clinicogenetic Studies of Maturity-Onset Diabetes of the Young to Unraveling Complex Mechanisms of Glucokinase Regulation

Jørn V. Sagen; Stella Odili; Lise Bjørkhaug; Dorothy Zelent; Carol Buettger; Jae Kwagh; Charles Stanley; Knut Dahl-Jørgensen; Carine de Beaufort; Graeme I. Bell; Yi Han; Joseph Grimsby; Rebecca Taub; Anders Molven; Oddmund Søvik; Pål R. Njølstad; Franz M. Matschinsky

Abstracts

View articletitled, From Clinicogenetic Studies of Maturity-Onset Diabetes of the Young to Unraveling Complex Mechanisms of Glucokinase Regulation

Open the PDF for in another window

Topics: glucokinase , glucose , mutation

Diabetes June 2006, Vol.55, 1713-1722. doi:https://doi.org/10.2337/db05-1513

Genome-Wide Linkage of Plasma Adiponectin Reveals a Major Locus on Chromosome 3q Distinct From the Adiponectin Structural Gene: The IRAS Family Study

Xiuqing Guo; Mohammed F. Saad; Carl D. Langefeld; Adrienne H. Williams; Jinrui Cui; Kent D. Taylor; Jill M. Norris; Sujata Jinagouda; Christine H. Darwin; Braxton D. Mitchell; Richard N. Bergman; Beth Sutton; Y.-D. Ida Chen; Lynne E. Wagenknecht; Donald W. Bowden; Jerome I. Rotter

Abstracts

View articletitled, Genome-Wide Linkage of Plasma Adiponectin Reveals a Major Locus on Chromosome 3q Distinct From the Adiponectin Structural Gene: The IRAS Family Study

Open the PDF for in another window

Topics: adiponectin , genetic linkage analysis , single nucleotide polymorphism , genome , genes

Diabetes June 2006, Vol.55, 1723-1730. doi:https://doi.org/10.2337/db05-0428

Functional Effects of Mutations at F35 in the NH₂-terminus of Kir6.2 (KCNJ11), Causing Neonatal Diabetes, and Response to Sulfonylurea Therapy

Peter Proks; Christophe Girard; Halvor Bævre; Pål R. Njølstad; Frances M. Ashcroft

Abstracts

View articletitled, Functional Effects of Mutations at F35 in the NH2-terminus of Kir6.2 (KCNJ11), Causing Neonatal Diabetes, and Response to Sulfonylurea Therapy

Supplementary data

Open the PDF for in another window

Topics: mutation , neonatal diabetes mellitus , sulfonylurea compounds , abcc8 gene , kcnj11 gene

Diabetes June 2006, Vol.55, 1731-1737. doi:https://doi.org/10.2337/db05-1420

Kir6.2 Mutations Associated With Neonatal Diabetes Reduce Expression of ATP-Sensitive K⁺ channels: Implications in Disease Mechanism and Sulfonylurea Therapy

Chia-Wei Lin; Yu-Wen Lin; Fei-Fei Yan; Jillene Casey; Malini Kochhar; Emily B. Pratt; Show-Ling Shyng

Abstracts

View articletitled, Kir6.2 Mutations Associated With Neonatal Diabetes Reduce Expression of ATP-Sensitive K+ channels: Implications in Disease Mechanism and Sulfonylurea Therapy

Supplementary data

Open the PDF for in another window

Topics: heterozygote , mutation , neonatal diabetes mellitus , sulfonylurea compounds , spermine

Diabetes June 2006, Vol.55, 1738-1746. doi:https://doi.org/10.2337/db05-1571

Combination of HLA-A24, -DQA1*03, and -DR9 Contributes to Acute-Onset and Early Complete β-Cell Destruction in Type 1 Diabetes: Longitudinal Study of Residual β-Cell Function

Koji Nakanishi; Hidetoshi Inoko

Abstract

View articletitled, Combination of HLA-A24, -DQA1*03, and -DR9 Contributes to Acute-Onset and Early Complete β-Cell Destruction in Type 1 Diabetes: Longitudinal Study of Residual β-Cell Function

Open the PDF for in another window

Topics: diabetes mellitus, type 1 , human leukocyte antigens , alleles , hla-dqa1

Diabetes June 2006, Vol.55, 1862-1868. doi:https://doi.org/10.2337/db05-1049

Signal Transduction

Exercise-Induced Phosphorylation of the Novel Akt Substrates AS160 and Filamin A in Human Skeletal Muscle

Atul Deshmukh; Vernon G. Coffey; Zhihui Zhong; Alexander V. Chibalin; John A. Hawley; Juleen R. Zierath

Abstracts

View articletitled, Exercise-Induced Phosphorylation of the Novel Akt Substrates AS160 and Filamin A in Human Skeletal Muscle

Open the PDF for in another window

Topics: antibodies , phosphoproteins , phosphorylation , proto-oncogene proteins c-akt , skeletal muscles

Diabetes June 2006, Vol.55, 1776-1782. doi:https://doi.org/10.2337/db05-1419

Evidence for a Mitochondrial Regulatory Pathway Defined by Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α, Estrogen-Related Receptor-α, and Mitofusin 2

Francesc X. Soriano; Marc Liesa; Daniel Bach; David C. Chan; Manuel Palacín; Antonio Zorzano

Abstracts

View articletitled, Evidence for a Mitochondrial Regulatory Pathway Defined by Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α, Estrogen-Related Receptor-α, and Mitofusin 2

Open the PDF for in another window

Topics: mfn2 gene , mitochondria , cold temperature , mice , skeletal muscles

Diabetes June 2006, Vol.55, 1783-1791. doi:https://doi.org/10.2337/db05-0509

Brief Genetics Reports

A Novel −192c/g Mutation in the Proximal P2 Promoter of the Hepatocyte Nuclear Factor-4α Gene (HNF4A) Associates With Late-Onset Diabetes

Jakob Ek; Sara P. Hansen; Maria Lajer; Carine Nicot; Trine W. Boesgaard; Stepanka Pruhova; Anders Johansen; Anders Albrechtsen; Knud Yderstræde; Jeannet Lauenborg; Marcelina Parrizas; Sylvia F. Boj; Torben Jørgensen; Knut Borch-Johnsen; Peter Damm; Jorge Ferrer; Jan Lebl; Oluf Pedersen; Torben Hansen

Abstracts

View articletitled, A Novel −192c/g Mutation in the Proximal P2 Promoter of the Hepatocyte Nuclear Factor-4α Gene (HNF4A) Associates With Late-Onset Diabetes

Supplementary data

Open the PDF for in another window

Topics: diabetes mellitus, type 2 , genes , heart sound p2 , hepatocytes , hnf4a gene

Diabetes June 2006, Vol.55, 1869-1873. doi:https://doi.org/10.2337/db05-1684

Fasting Insulin and Obesity-Related Phenotypes Are Linked to Chromosome 2p: The Strong Heart Family Study

Vincent P. Diego; Harald H.H. Göring; Shelley A. Cole; Laura Almasy; Thomas D. Dyer; John Blangero; Ravindranath Duggirala; Sandra Laston; Charlotte Wenger; Teresa Cantu; Bennett Dyke; Kari North; Theodore Schurr; Lyle G. Best; Richard B. Devereux; Richard R. Fabsitz; Barbara V. Howard; Jean W. MacCluer

Abstracts

View articletitled, Fasting Insulin and Obesity-Related Phenotypes Are Linked to Chromosome 2p: The Strong Heart Family Study

Open the PDF for in another window

Topics: chromosomes , fasting , heart , insulin , obesity

Diabetes June 2006, Vol.55, 1874-1878. doi:https://doi.org/10.2337/db05-0668

Linkage but Not Association of Calpain-10 to Type 2 Diabetes Replicated in Northern Sweden

Elisabet Einarsdottir; Sofia Mayans; Karin Ruikka; Stefan A. Escher; Petter Lindgren; Åsa Ågren; Mats Eliasson; Dan Holmberg

Abstracts

View articletitled, Linkage but Not Association of Calpain-10 to Type 2 Diabetes Replicated in Northern Sweden

Supplementary data

Open the PDF for in another window

Topics: calpain 10 , diabetes mellitus, type 2 , single nucleotide polymorphism , genetic linkage analysis , genome

Diabetes June 2006, Vol.55, 1879-1883. doi:https://doi.org/10.2337/db05-1495

Significant Linkage of BMI to Chromosome 10p in the U.K. Population and Evaluation of GAD2 as a Positional Candidate

Christopher J. Groves; Eleftheria Zeggini; Mark Walker; Graham A. Hitman; Jonathan C. Levy; Stephen O’Rahilly; Andrew T. Hattersley; Mark I. McCarthy; Steven Wiltshire

Abstracts

View articletitled, Significant Linkage of BMI to Chromosome 10p in the U.K. Population and Evaluation of GAD2 as a Positional Candidate

Open the PDF for in another window

Topics: body mass index procedure , chromosome 10p , single nucleotide polymorphism , obesity , genetic pedigree

Diabetes June 2006, Vol.55, 1884-1889. doi:https://doi.org/10.2337/db05-1674

The Variable Number of Tandem Repeats Upstream of the Insulin Gene Is a Susceptibility Locus for Latent Autoimmune Diabetes in Adults

Minal Desai; Eleftheria Zeggini; Virginia A. Horton; Katharine R. Owen; Andrew T. Hattersley; Jonathan C. Levy; Graham A. Hitman; Mark Walker; Rury R. Holman; Mark I. McCarthy; Anne Clark

Abstracts

View articletitled, The Variable Number of Tandem Repeats Upstream of the Insulin Gene Is a Susceptibility Locus for Latent Autoimmune Diabetes in Adults

Open the PDF for in another window

Topics: diabetes mellitus, type 1 , genes , insulin , latent autoimmune diabetes of adulthood , minisatellite repeats

Diabetes June 2006, Vol.55, 1890-1894. doi:https://doi.org/10.2337/db06-0089

HLA Genotyping Supports a Nonautoimmune Etiology in Patients Diagnosed With Diabetes Under the Age of 6 Months

Emma L. Edghill; Rachel J. Dix; Sarah E. Flanagan; Polly J. Bingley; Andrew T. Hattersley; Sian Ellard; Kathleen M. Gillespie

Abstracts

View articletitled, HLA Genotyping Supports a Nonautoimmune Etiology in Patients Diagnosed With Diabetes Under the Age of 6 Months

Supplementary data

Open the PDF for in another window

Topics: genotype determination , human leukocyte antigens , diabetes mellitus, type 1 , genotype , kcnj11 gene

Diabetes June 2006, Vol.55, 1895-1898. doi:https://doi.org/10.2337/db06-0094

A Hepatocyte Nuclear Factor-4α Gene (HNF4A) P2 Promoter Haplotype Linked With Late-Onset Diabetes: Studies of HNF4A Variants in the Norwegian MODY Registry

Helge Ræder; Lise Bjørkhaug; Stefan Johansson; Kjersti Mangseth; Jørn V. Sagen; Anne Hunting; Ivar Følling; Odd Johansen; Marit Bjørgaas; Povel N. Paus; Oddmund Søvik; Anders Molven; Pål R. Njølstad

Abstracts

View articletitled, A Hepatocyte Nuclear Factor-4α Gene (HNF4A) P2 Promoter Haplotype Linked With Late-Onset Diabetes: Studies of HNF4A Variants in the Norwegian MODY Registry

Supplementary data

Open the PDF for in another window

Topics: haplotypes , heart sound p2 , hepatocytes , hnf4a gene , maturity onset diabetes mellitus in young

Diabetes June 2006, Vol.55, 1899-1903. doi:https://doi.org/10.2337/db05-1677

Erratum

Errata

Extract

View articletitled, Errata

Open the PDF for in another window

Topics: amino acids , ampk , autonomic function , diabetes mellitus, type 2 , genes

Diabetes June 2006, Vol.55, 1904. doi:https://doi.org/10.2337/db06-er06

Issues

Lilly Lecture 2005

Metabolism

Obesity Studies

Immunology and Transplantation

Islet Studies

Pathophysiology

Complications

Pharmacology & Therapeutics

Genetics

Signal Transduction

Brief Genetics Reports

Erratum

Email alerts

RSS Feeds

Journals

Books

Clinical Compendia

News

Other

About

Resources

This Feature Is Available To Subscribers Only