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Issues
Lilly Lecture 2005
Adipose Tissue: From Lipid Storage Compartment to Endocrine Organ
Diabetes June 2006, Vol.55, 1537-1545. doi:https://doi.org/10.2337/db06-0263
Metabolism
Reversal of Type 1 Diabetes by Engineering a Glucose Sensor in Skeletal Muscle
Alex Mas; Joel Montané; Xavier M. Anguela; Sergio Muñoz; Anne M. Douar; Efren Riu; Pedro Otaegui; Fatima Bosch
Diabetes June 2006, Vol.55, 1546-1553. doi:https://doi.org/10.2337/db05-1615
Inhibition of Fructose 1,6-Bisphosphatase Reduces Excessive Endogenous Glucose Production and Attenuates Hyperglycemia in Zucker Diabetic Fatty Rats
Paul D. van Poelje; Scott C. Potter; Visvanathan C. Chandramouli; Bernard R. Landau; Qun Dang; Mark D. Erion
Diabetes June 2006, Vol.55, 1747-1754. doi:https://doi.org/10.2337/db05-1443
Activation of AMP-Activated Protein Kinase Within the Ventromedial Hypothalamus Amplifies Counterregulatory Hormone Responses in Rats With Defective Counterregulation
Rory J. McCrimmon; Xiaoning Fan; Haiying Cheng; Ewan McNay; Owen Chan; Margaret Shaw; Yuyan Ding; Wanling Zhu; Robert S. Sherwin
Diabetes June 2006, Vol.55, 1755-1760. doi:https://doi.org/10.2337/db05-1359
Time-Dependent Effects of Free Fatty Acids on Glucose Effectiveness in Type 2 Diabetes
Preeti Kishore; Julia Tonelli; Sudha Koppaka; Corina Fratila; Anita Bose; Do-Eun Lee; Kalpana Reddy; Meredith Hawkins
Diabetes June 2006, Vol.55, 1761-1768. doi:https://doi.org/10.2337/db05-0988
Reduced Access to Insulin-Sensitive Tissues in Dogs With Obesity Secondary to Increased Fat Intake
Martin Ellmerer; Marianthe Hamilton-Wessler; Stella P. Kim; Katrin Huecking; Erlinda Kirkman; Jenny Chiu; Joyce Richey; Richard N. Bergman
Diabetes June 2006, Vol.55, 1769-1775. doi:https://doi.org/10.2337/db05-1509
Obesity Studies
Increased Infiltration of Macrophages in Omental Adipose Tissue Is Associated With Marked Hepatic Lesions in Morbid Human Obesity
Raffaella Cancello; Joan Tordjman; Christine Poitou; Gaël Guilhem; Jean Luc Bouillot; Danielle Hugol; Christiane Coussieu; Arnaud Basdevant; Avner Bar Hen; Pierre Bedossa; Michèle Guerre-Millo; Karine Clément
Diabetes June 2006, Vol.55, 1554-1561. doi:https://doi.org/10.2337/db06-0133
Downregulation of Electron Transport Chain Genes in Visceral Adipose Tissue in Type 2 Diabetes Independent of Obesity and Possibly Involving Tumor Necrosis Factor-α
Ingrid Dahlman; Margaretha Forsgren; Annelie Sjögren; Elisabet Arvidsson Nordström; Maria Kaaman; Erik Näslund; Anneli Attersand; Peter Arner
Diabetes June 2006, Vol.55, 1792-1799. doi:https://doi.org/10.2337/db05-1421
Immunology and Transplantation
Lymphocytic Infiltration and Immune Activation in Metallothionein Promoter–Exendin-4 (MT-Exendin) Transgenic Mice
Diabetes June 2006, Vol.55, 1562-1570. doi:https://doi.org/10.2337/db05-1502
Induction of Tolerance in Type 1 Diabetes via Both CD4+CD25+ T Regulatory Cells and T Regulatory Type 1 Cells
Manuela Battaglia; Angela Stabilini; Elena Draghici; Barbara Migliavacca; Silvia Gregori; Ezio Bonifacio; Maria-Grazia Roncarolo
Diabetes June 2006, Vol.55, 1571-1580. doi:https://doi.org/10.2337/db05-1576
Islet Studies
Glucose Regulates Foxo1 Through Insulin Receptor Signaling in the Pancreatic Islet β-cell
Diabetes June 2006, Vol.55, 1581-1591. doi:https://doi.org/10.2337/db05-0678
Peroxisome Proliferator–Activated Receptor α Improves Pancreatic Adaptation to Insulin Resistance in Obese Mice and Reduces Lipotoxicity in Human Islets
Fanny Lalloyer; Brigitte Vandewalle; Frédéric Percevault; Gérard Torpier; Julie Kerr-Conte; Maaike Oosterveer; Réjane Paumelle; Jean-Charles Fruchart; Folkert Kuipers; François Pattou; Catherine Fiévet; Bart Staels
Diabetes June 2006, Vol.55, 1605-1613. doi:https://doi.org/10.2337/db06-0016
The Role of Phosphoinositide 3-Kinase/Akt Signaling in Low-Dose Mercury–Induced Mouse Pancreatic β-Cell Dysfunction In Vitro and In Vivo
Ya Wen Chen; Chun Fa Huang; Keh Sung Tsai; Rong Sen Yang; Cheng Chieh Yen; Ching Yao Yang; Shoei Yn Lin-Shiau; Shing Hwa Liu
Diabetes June 2006, Vol.55, 1614-1624. doi:https://doi.org/10.2337/db06-0029
Pathophysiology
Islet Inflammation and Fibrosis in a Spontaneous Model of Type 2 Diabetes, the GK Rat
Françoise Homo-Delarche; Sophie Calderari; Jean-Claude Irminger; Marie-Noëlle Gangnerau; Josiane Coulaud; Katharina Rickenbach; Manuel Dolz; Philippe Halban; Bernard Portha; Patricia Serradas
Diabetes June 2006, Vol.55, 1625-1633. doi:https://doi.org/10.2337/db05-1526
Nutritional Supplementation With trans-10, cis-12–Conjugated Linoleic Acid Induces Inflammation of White Adipose Tissue
Diabetes June 2006, Vol.55, 1634-1641. doi:https://doi.org/10.2337/db06-0036
Cognitive Performance, Psychological Well-Being, and Brain Magnetic Resonance Imaging in Older Patients With Type 1 Diabetes
Augustina M.A. Brands; Roy P.C. Kessels; Roel P.L.M. Hoogma; Johanna M.L. Henselmans; Johanna W. van der Beek Boter; L. Jaap Kappelle; Edward H.F. de Haan; Geert Jan Biessels
Diabetes June 2006, Vol.55, 1800-1806. doi:https://doi.org/10.2337/db05-1226
Hyperglycemia Stimulates Coagulation, Whereas Hyperinsulinemia Impairs Fibrinolysis in Healthy Humans
Michiel E. Stegenga; Saskia N. van der Crabben; Marcel Levi; Alex F. de Vos; Michael W. Tanck; Hans P. Sauerwein; Tom van der Poll
Diabetes June 2006, Vol.55, 1807-1812. doi:https://doi.org/10.2337/db05-1543
Decreased Muscle Strength and Quality in Older Adults With Type 2 Diabetes: The Health, Aging, and Body Composition Study
Seok Won Park; Bret H. Goodpaster; Elsa S. Strotmeyer; Nathalie de Rekeneire; Tamara B. Harris; Ann V. Schwartz; Frances A. Tylavsky; Anne B. Newman
Diabetes June 2006, Vol.55, 1813-1818. doi:https://doi.org/10.2337/db05-1183
Complications
Deletion of p66Shc Longevity Gene Protects Against Experimental Diabetic Glomerulopathy by Preventing Diabetes-Induced Oxidative Stress
Stefano Menini; Lorena Amadio; Giovanna Oddi; Carlo Ricci; Carlo Pesce; Francesco Pugliese; Marco Giorgio; Enrica Migliaccio; PierGiuseppe Pelicci; Carla Iacobini; Giuseppe Pugliese
Diabetes June 2006, Vol.55, 1642-1650. doi:https://doi.org/10.2337/db05-1477
Altered Endothelial Nitric Oxide Synthase Targeting and Conformation and Caveolin-1 Expression in the Diabetic Kidney
Radko Komers; William E. Schutzer; John F. Reed; Jessie N. Lindsley; Terry T. Oyama; David C. Buck; Scott L. Mader; Sharon Anderson
Diabetes June 2006, Vol.55, 1651-1659. doi:https://doi.org/10.2337/db05-1595
Apoptosis Signal-Regulating Kinase 1 Mediates Cellular Senescence Induced by High Glucose in Endothelial Cells
Toyohiko Yokoi; Keisuke Fukuo; Osamu Yasuda; Mizuo Hotta; Junichi Miyazaki; Yukihiro Takemura; Hidenobu Kawamoto; Hidenori Ichijo; Toshio Ogihara
Diabetes June 2006, Vol.55, 1660-1665. doi:https://doi.org/10.2337/db05-1607
Thiazolidinediones Ameliorate Diabetic Nephropathy via Cell Cycle–Dependent Mechanisms
Tatsuo Okada; Jun Wada; Kazuyuki Hida; Jun Eguchi; Izumi Hashimoto; Masako Baba; Akihiro Yasuhara; Kenichi Shikata; Hirofumi Makino
Diabetes June 2006, Vol.55, 1666-1677. doi:https://doi.org/10.2337/db05-1285
Salutary Effect of Pigment Epithelium–Derived Factor in Diabetic Nephropathy: Evidence for Antifibrogenic Activities
Diabetes June 2006, Vol.55, 1678-1685. doi:https://doi.org/10.2337/db05-1448
Poly(ADP-Ribose) Polymerase Inhibition Alleviates Experimental Diabetic Sensory Neuropathy
Olga Ilnytska; Valeriy V. Lyzogubov; Martin J. Stevens; Viktor R. Drel; Nazar Mashtalir; Pal Pacher; Mark A. Yorek; Irina G. Obrosova
Diabetes June 2006, Vol.55, 1686-1694. doi:https://doi.org/10.2337/db06-0067
Diabetic Nephropathy Is Associated With Gene Expression Levels of Oxidative Phosphorylation and Related Pathways
Chunmei Huang; Youngki Kim; M. Luiza Caramori; Jason H. Moore; Stephen S. Rich; Josyf C. Mychaleckyj; Paul C. Walker; Michael Mauer
Diabetes June 2006, Vol.55, 1826-1831. doi:https://doi.org/10.2337/db05-1438
Adiponectin Suppression of High-Glucose–Induced Reactive Oxygen Species in Vascular Endothelial Cells: Evidence for Involvement of a cAMP Signaling Pathway
Raogo Ouedraogo; Xiangdong Wu; Shi-Qiong Xu; Lauren Fuchsel; Hiroyuki Motoshima; Kalyankar Mahadev; Kelly Hough; Rosario Scalia; Barry J. Goldstein
Diabetes June 2006, Vol.55, 1840-1846. doi:https://doi.org/10.2337/db05-1174
Gene Transfer of an Engineered Transcription Factor Promoting Expression of VEGF-A Protects Against Experimental Diabetic Neuropathy
Sally A. Price; Carolyn Dent; Beatriz Duran-Jimenez; Yuxin Liang; Lei Zhang; Edward J. Rebar; Casey C. Case; Philip D. Gregory; Tyler J. Martin; S. Kaye Spratt; David R. Tomlinson
Diabetes June 2006, Vol.55, 1847-1854. doi:https://doi.org/10.2337/db05-1060
Pharmacology & Therapeutics
Chronic Inhibition of Dipeptidyl Peptidase-4 With a Sitagliptin Analog Preserves Pancreatic β-Cell Mass and Function in a Rodent Model of Type 2 Diabetes
James Mu; John Woods; Yun-Ping Zhou; Ranabir Sinha Roy; Zhihua Li; Emanuel Zycband; Yue Feng; Lan Zhu; Cai Li; Andrew D. Howard; David. E. Moller; Nancy A. Thornberry; Bei B. Zhang
Diabetes June 2006, Vol.55, 1695-1704. doi:https://doi.org/10.2337/db05-1602
The Experimental Type 2 Diabetes Therapy Glycogen Phosphorylase Inhibition Can Impair Aerobic Muscle Function During Prolonged Contraction
Diabetes June 2006, Vol.55, 1855-1861. doi:https://doi.org/10.2337/db05-1687
Genetics
Mutations at the Same Residue (R50) of Kir6.2 (KCNJ11) That Cause Neonatal Diabetes Produce Different Functional Effects
Kenju Shimomura; Christophe A.J. Girard; Peter Proks; Joanna Nazim; Jonathan D. Lippiat; Franco Cerutti; Renata Lorini; Sian Ellard; Andrew T. Hattersley; Fabrizio Barbetti; Frances M. Ashcroft
Diabetes June 2006, Vol.55, 1705-1712. doi:https://doi.org/10.2337/db05-1640
From Clinicogenetic Studies of Maturity-Onset Diabetes of the Young to Unraveling Complex Mechanisms of Glucokinase Regulation
Jørn V. Sagen; Stella Odili; Lise Bjørkhaug; Dorothy Zelent; Carol Buettger; Jae Kwagh; Charles Stanley; Knut Dahl-Jørgensen; Carine de Beaufort; Graeme I. Bell; Yi Han; Joseph Grimsby; Rebecca Taub; Anders Molven; Oddmund Søvik; Pål R. Njølstad; Franz M. Matschinsky
Diabetes June 2006, Vol.55, 1713-1722. doi:https://doi.org/10.2337/db05-1513
Genome-Wide Linkage of Plasma Adiponectin Reveals a Major Locus on Chromosome 3q Distinct From the Adiponectin Structural Gene: The IRAS Family Study
Xiuqing Guo; Mohammed F. Saad; Carl D. Langefeld; Adrienne H. Williams; Jinrui Cui; Kent D. Taylor; Jill M. Norris; Sujata Jinagouda; Christine H. Darwin; Braxton D. Mitchell; Richard N. Bergman; Beth Sutton; Y.-D. Ida Chen; Lynne E. Wagenknecht; Donald W. Bowden; Jerome I. Rotter
Diabetes June 2006, Vol.55, 1723-1730. doi:https://doi.org/10.2337/db05-0428
Functional Effects of Mutations at F35 in the NH2-terminus of Kir6.2 (KCNJ11), Causing Neonatal Diabetes, and Response to Sulfonylurea Therapy
Diabetes June 2006, Vol.55, 1731-1737. doi:https://doi.org/10.2337/db05-1420
Kir6.2 Mutations Associated With Neonatal Diabetes Reduce Expression of ATP-Sensitive K+ channels: Implications in Disease Mechanism and Sulfonylurea Therapy
Chia-Wei Lin; Yu-Wen Lin; Fei-Fei Yan; Jillene Casey; Malini Kochhar; Emily B. Pratt; Show-Ling Shyng
Diabetes June 2006, Vol.55, 1738-1746. doi:https://doi.org/10.2337/db05-1571
Signal Transduction
Brief Genetics Reports
A Novel −192c/g Mutation in the Proximal P2 Promoter of the Hepatocyte Nuclear Factor-4α Gene (HNF4A) Associates With Late-Onset Diabetes
Jakob Ek; Sara P. Hansen; Maria Lajer; Carine Nicot; Trine W. Boesgaard; Stepanka Pruhova; Anders Johansen; Anders Albrechtsen; Knud Yderstræde; Jeannet Lauenborg; Marcelina Parrizas; Sylvia F. Boj; Torben Jørgensen; Knut Borch-Johnsen; Peter Damm; Jorge Ferrer; Jan Lebl; Oluf Pedersen; Torben Hansen
Diabetes June 2006, Vol.55, 1869-1873. doi:https://doi.org/10.2337/db05-1684
Fasting Insulin and Obesity-Related Phenotypes Are Linked to Chromosome 2p: The Strong Heart Family Study
Vincent P. Diego; Harald H.H. Göring; Shelley A. Cole; Laura Almasy; Thomas D. Dyer; John Blangero; Ravindranath Duggirala; Sandra Laston; Charlotte Wenger; Teresa Cantu; Bennett Dyke; Kari North; Theodore Schurr; Lyle G. Best; Richard B. Devereux; Richard R. Fabsitz; Barbara V. Howard; Jean W. MacCluer
Diabetes June 2006, Vol.55, 1874-1878. doi:https://doi.org/10.2337/db05-0668
Linkage but Not Association of Calpain-10 to Type 2 Diabetes Replicated in Northern Sweden
Elisabet Einarsdottir; Sofia Mayans; Karin Ruikka; Stefan A. Escher; Petter Lindgren; Åsa Ågren; Mats Eliasson; Dan Holmberg
Diabetes June 2006, Vol.55, 1879-1883. doi:https://doi.org/10.2337/db05-1495
Significant Linkage of BMI to Chromosome 10p in the U.K. Population and Evaluation of GAD2 as a Positional Candidate
Christopher J. Groves; Eleftheria Zeggini; Mark Walker; Graham A. Hitman; Jonathan C. Levy; Stephen O’Rahilly; Andrew T. Hattersley; Mark I. McCarthy; Steven Wiltshire
Diabetes June 2006, Vol.55, 1884-1889. doi:https://doi.org/10.2337/db05-1674
The Variable Number of Tandem Repeats Upstream of the Insulin Gene Is a Susceptibility Locus for Latent Autoimmune Diabetes in Adults
Minal Desai; Eleftheria Zeggini; Virginia A. Horton; Katharine R. Owen; Andrew T. Hattersley; Jonathan C. Levy; Graham A. Hitman; Mark Walker; Rury R. Holman; Mark I. McCarthy; Anne Clark
Diabetes June 2006, Vol.55, 1890-1894. doi:https://doi.org/10.2337/db06-0089
HLA Genotyping Supports a Nonautoimmune Etiology in Patients Diagnosed With Diabetes Under the Age of 6 Months
Emma L. Edghill; Rachel J. Dix; Sarah E. Flanagan; Polly J. Bingley; Andrew T. Hattersley; Sian Ellard; Kathleen M. Gillespie
Diabetes June 2006, Vol.55, 1895-1898. doi:https://doi.org/10.2337/db06-0094
A Hepatocyte Nuclear Factor-4α Gene (HNF4A) P2 Promoter Haplotype Linked With Late-Onset Diabetes: Studies of HNF4A Variants in the Norwegian MODY Registry
Helge Ræder; Lise Bjørkhaug; Stefan Johansson; Kjersti Mangseth; Jørn V. Sagen; Anne Hunting; Ivar Følling; Odd Johansen; Marit Bjørgaas; Povel N. Paus; Oddmund Søvik; Anders Molven; Pål R. Njølstad
Diabetes June 2006, Vol.55, 1899-1903. doi:https://doi.org/10.2337/db05-1677