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Issues
Perspectives in Diabetes
Interventional Strategies to Prevent β-Cell Apoptosis in Islet Transplantation
Diabetes July 2006, Vol.55, 1907-1914. doi:https://doi.org/10.2337/db05-1254
Signal Transduction
Regulation of Metabolic Responses by Adipocyte/ Macrophage Fatty Acid–Binding Proteins in Leptin-Deficient Mice
Haiming Cao; Kazuhisa Maeda; Cem Z. Gorgun; Hyo-Jeong Kim; So-Young Park; Gerald I. Shulman; Jason K. Kim; Gökhan S. Hotamisligil
Diabetes July 2006, Vol.55, 1915-1922. doi:https://doi.org/10.2337/db05-1496
A Glucose Sensor Role for Glucokinase in Anterior Pituitary Cells
Dorothy Zelent; Maria L. Golson; Brigitte Koeberlein; Roel Quintens; Leentje van Lommel; Carol Buettger; Heather Weik-Collins; Rebecca Taub; Joseph Grimsby; Frans Schuit; Klaus H. Kaestner; Franz M. Matschinsky
Diabetes July 2006, Vol.55, 1923-1929. doi:https://doi.org/10.2337/db06-0151
Leptin Suppresses Stearoyl-CoA Desaturase 1 by Mechanisms Independent of Insulin and Sterol Regulatory Element–Binding Protein-1c
Diabetes July 2006, Vol.55, 2032-2041. doi:https://doi.org/10.2337/db05-0742
Targeting Foxo1 in Mice Using Antisense Oligonucleotide Improves Hepatic and Peripheral Insulin Action
Varman T. Samuel; Cheol Soo Choi; Trevor G. Phillips; Anthony J. Romanelli; John G. Geisler; Sanjay Bhanot; Robert McKay; Brett Monia; John R. Shutter; Richard A. Lindberg; Gerald I. Shulman; Murielle M. Veniant
Diabetes July 2006, Vol.55, 2042-2050. doi:https://doi.org/10.2337/db05-0705
AMPK-Mediated AS160 Phosphorylation in Skeletal Muscle Is Dependent on AMPK Catalytic and Regulatory Subunits
Jonas T. Treebak; Stephan Glund; Atul Deshmukh; Ditte K. Klein; Yun Chau Long; Thomas E. Jensen; Sebastian B. Jørgensen; Benoit Viollet; Leif Andersson; Dietbert Neumann; Theo Wallimann; Erik A. Richter; Alexander V. Chibalin; Juleen R. Zierath; Jørgen F.P. Wojtaszewski
Diabetes July 2006, Vol.55, 2051-2058. doi:https://doi.org/10.2337/db06-0175
Serum- and Glucocorticoid-Inducible Kinase 1 Mediates Salt Sensitivity of Glucose Tolerance
Krishna M. Boini; Anita M. Hennige; Dan Yang Huang; Björn Friedrich; Monica Palmada; Christoph Boehmer; Florian Grahammer; Ferruh Artunc; Susanne Ullrich; Diana Avram; Hartmut Osswald; Peer Wulff; Dietmar Kuhl; Volker Vallon; Hans-Ulrich Häring; Florian Lang
Diabetes July 2006, Vol.55, 2059-2066. doi:https://doi.org/10.2337/db05-1038
Distinct Signals Regulate AS160 Phosphorylation in Response to Insulin, AICAR, and Contraction in Mouse Skeletal Muscle
Henning F. Kramer; Carol A. Witczak; Nobuharu Fujii; Niels Jessen; Eric B. Taylor; David E. Arnolds; Kei Sakamoto; Michael F. Hirshman; Laurie J. Goodyear
Diabetes July 2006, Vol.55, 2067-2076. doi:https://doi.org/10.2337/db06-0150
The Role of Ca2+ Influx for Insulin-Mediated Glucose Uptake in Skeletal Muscle
Johanna T. Lanner; Abram Katz; Pasi Tavi; Marie E. Sandström; Shi-Jin Zhang; Charlott Wretman; Stephen James; Jérémy Fauconnier; Jan Lännergren; Joseph D. Bruton; Håkan Westerblad
Diabetes July 2006, Vol.55, 2077-2083. doi:https://doi.org/10.2337/db05-1613
Mitochondrial Reactive Oxygen Species Are Required for Hypothalamic Glucose Sensing
Corinne Leloup; Christophe Magnan; Alexandre Benani; Emilie Bonnet; Thierry Alquier; Géraldine Offer; Audrey Carriere; Alain Périquet; Yvette Fernandez; Alain Ktorza; Louis Casteilla; Luc Pénicaud
Diabetes July 2006, Vol.55, 2084-2090. doi:https://doi.org/10.2337/db06-0086
Islet Studies
Spontaneous Recovery From Hyperglycemia by Regeneration of Pancreatic β-Cells in Kir6.2G132S Transgenic Mice
Diabetes July 2006, Vol.55, 1930-1938. doi:https://doi.org/10.2337/db05-1459
Pathophysiology
Cystic Fibrosis Transmembrane Conductance Regulator Deficiency Exacerbates Islet Cell Dysfunction After β-Cell Injury
Michael S. Stalvey; Christian Muller; Desmond A. Schatz; Clive H. Wasserfall; Martha L. Campbell-Thompson; Douglas W. Theriaque; Terence R. Flotte; Mark A. Atkinson
Diabetes July 2006, Vol.55, 1939-1945. doi:https://doi.org/10.2337/db05-1647
Complications
Aldose Reductase–Deficient Mice Are Protected From Delayed Motor Nerve Conduction Velocity, Increased c-Jun NH2-Terminal Kinase Activation, Depletion of Reduced Glutathione, Increased Superoxide Accumulation, and DNA Damage
Eric C.M. Ho; Karen S.L. Lam; Yuk Shan Chen; Johnny C.W. Yip; Meena Arvindakshan; Shin-Ichiro Yamagishi; Soroku Yagihashi; Peter J. Oates; Craig A. Ellery; Stephen S.M. Chung; Sookja K. Chung
Diabetes July 2006, Vol.55, 1946-1953. doi:https://doi.org/10.2337/db05-1497
Comparison of Serum High–Molecular Weight (HMW) Adiponectin With Total Adiponectin Concentrations in Type 2 Diabetic Patients With Coronary Artery Disease Using a Novel Enzyme-Linked Immunosorbent Assay to Detect HMW Adiponectin
Yoshimasa Aso; Ruriko Yamamoto; Sadao Wakabayashi; Toshihiko Uchida; Kan Takayanagi; Kohzo Takebayashi; Takehiko Okuno; Teruo Inoue; Koichi Node; Takashi Tobe; Toshihiko Inukai; Yasuko Nakano
Diabetes July 2006, Vol.55, 1954-1960. doi:https://doi.org/10.2337/db05-1525
Mesangial Cell Hypertrophy by High Glucose Is Mediated by Downregulation of the Tumor Suppressor PTEN
Diabetes July 2006, Vol.55, 2115-2125. doi:https://doi.org/10.2337/db05-1326
The Relationship Between Plasma Osteoprotegerin and Endothelium-Dependent Arterial Dilation in Type 2 Diabetes
Diabetes July 2006, Vol.55, 2126-2131. doi:https://doi.org/10.2337/db06-0231
ACE and ACE2 Activity in Diabetic Mice
Jan Wysocki; Minghao Ye; Maria José Soler; Susan B. Gurley; Hong D. Xiao; Kenneth E. Bernstein; Thomas M. Coffman; Sheldon Chen; Daniel Batlle
Diabetes July 2006, Vol.55, 2132-2139. doi:https://doi.org/10.2337/db06-0033
Genetics
Common Hepatic Nuclear Factor-4α Variants Are Associated With High Serum Lipid Levels and the Metabolic Syndrome
Daphna Weissglas-Volkov; Adriana Huertas-Vazquez; Elina Suviolahti; Jenny Lee; Christopher Plaisier; Samuel Canizales-Quinteros; Teresa Tusie-Luna; Carlos Aguilar-Salinas; Marja-Riitta Taskinen; Päivi Pajukanta
Diabetes July 2006, Vol.55, 1970-1977. doi:https://doi.org/10.2337/db06-0035
Transgenic Insulin (B:9-23) T-Cell Receptor Mice Develop Autoimmune Diabetes Dependent Upon RAG Genotype, H-2g7 Homozygosity, and Insulin 2 Gene Knockout
Jean M. Jasinski; Liping Yu; Maki Nakayama; Marcella M. Li; Myra A. Lipes; George S. Eisenbarth; Edwin Liu
Diabetes July 2006, Vol.55, 1978-1984. doi:https://doi.org/10.2337/db06-0058
Coincident Linkage of Type 2 Diabetes, Metabolic Syndrome, and Measures of Cardiovascular Disease in a Genome Scan of the Diabetes Heart Study
Donald W. Bowden; Megan Rudock; Julie Ziegler; Allison B. Lehtinen; Jianzhao Xu; Lynne E. Wagenknecht; David Herrington; Stephen S. Rich; Barry I. Freedman; J. Jeffrey Carr; Carl D. Langefeld
Diabetes July 2006, Vol.55, 1985-1994. doi:https://doi.org/10.2337/db06-0003
Common Variants of the Endothelial Nitric Oxide Synthase Gene and the Risk of Coronary Heart Disease Among U.S. Diabetic Men
Diabetes July 2006, Vol.55, 2140-2147. doi:https://doi.org/10.2337/db05-1535
New Methodologies and Databases
Evaluation of the Effect of Gain on the Meal Response of an Automated Closed-Loop Insulin Delivery System
Diabetes July 2006, Vol.55, 1995-2000. doi:https://doi.org/10.2337/db05-1346
Metabolism
Effects of Age and Sex on Postprandial Glucose Metabolism : Differences in Glucose Turnover, Insulin Secretion, Insulin Action, and Hepatic Insulin Extraction
Rita Basu; Chiara Dalla Man; Marco Campioni; Ananda Basu; George Klee; Gianna Toffolo; Claudio Cobelli; Robert A. Rizza
Diabetes July 2006, Vol.55, 2001-2014. doi:https://doi.org/10.2337/db05-1692
A Choline-Deficient Diet Exacerbates Fatty Liver but Attenuates Insulin Resistance and Glucose Intolerance in Mice Fed a High-Fat Diet
Diabetes July 2006, Vol.55, 2015-2020. doi:https://doi.org/10.2337/db06-0097
Plasma Interleukin-6 Levels Are Independently Associated With Insulin Secretion in a Cohort of Italian-Caucasian Nondiabetic Subjects
Francesco Andreozzi; Emanuela Laratta; Marina Cardellini; Maria A. Marini; Renato Lauro; Marta L. Hribal; Francesco Perticone; Giorgio Sesti
Diabetes July 2006, Vol.55, 2021-2024. doi:https://doi.org/10.2337/db06-0063
Mechanisms of Recovery From Type 2 Diabetes After Malabsorptive Bariatric Surgery
Caterina Guidone; Melania Manco; Elena Valera-Mora; Amerigo Iaconelli; Donatella Gniuli; Andrea Mari; Giuseppe Nanni; Marco Castagneto; Menotti Calvani; Geltrude Mingrone
Diabetes July 2006, Vol.55, 2025-2031. doi:https://doi.org/10.2337/db06-0068
Obesity Studies
Identification of a Novel Member of the Carboxylesterase Family That Hydrolyzes Triacylglycerol : A Potential Role in Adipocyte Lipolysis
Hiroaki Okazaki; Masaki Igarashi; Makiko Nishi; Makiko Tajima; Motohiro Sekiya; Sachiko Okazaki; Naoya Yahagi; Ken Ohashi; Kazuhisa Tsukamoto; Michiyo Amemiya-Kudo; Takashi Matsuzaka; Hitoshi Shimano; Nobuhiro Yamada; Junken Aoki; Rei Morikawa; Yasukazu Takanezawa; Hiroyuki Arai; Ryozo Nagai; Takashi Kadowaki; Jun-ichi Osuga; Shun Ishibashi
Diabetes July 2006, Vol.55, 2091-2097. doi:https://doi.org/10.2337/db05-0585
Immunology and Transplantation
Deficiency in NOD Antigen-Presenting Cell Function May Be Responsible for Suboptimal CD4+CD25+ T-Cell–Mediated Regulation and Type 1 Diabetes Development in NOD Mice
Pascale Alard; Jean N. Manirarora; Sarah A. Parnell; Jason L. Hudkins; Sherry L. Clark; Michele M. Kosiewicz
Diabetes July 2006, Vol.55, 2098-2105. doi:https://doi.org/10.2337/db05-0810
Brief Genetics Reports
Single Nucleotide Polymorphisms of PPARD in Combination With the Gly482Ser Substitution of PGC-1A and the Pro12Ala Substitution of PPARG2 Predict the Conversion From Impaired Glucose Tolerance to Type 2 Diabetes: The STOP-NIDDM Trial
Laura Andrulionytė; Paula Peltola; Jean-Louis Chiasson; Markku Laakso; for the STOP-NIDDM Study Group
Diabetes July 2006, Vol.55, 2148-2152. doi:https://doi.org/10.2337/db05-1629
Deletion of Nicotinamide Nucleotide Transhydrogenase : A New Quantitive Trait Locus Accounting for Glucose Intolerance in C57BL/6J Mice
Diabetes July 2006, Vol.55, 2153-2156. doi:https://doi.org/10.2337/db06-0358