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Signal Transduction
Liver-Specific Inhibition of ChREBP Improves Hepatic Steatosis and Insulin Resistance in ob/ob Mice
Renaud Dentin; Fadila Benhamed; Isabelle Hainault; Véronique Fauveau; Fabienne Foufelle; Jason R.B. Dyck; Jean Girard; Catherine Postic
Diabetes August 2006, Vol.55, 2159-2170. doi:https://doi.org/10.2337/db06-0200
Temporal Dynamics of Tyrosine Phosphorylation in Insulin Signaling
Diabetes August 2006, Vol.55, 2171-2179. doi:https://doi.org/10.2337/db06-0148
Polyphenols Stimulate AMP-Activated Protein Kinase, Lower Lipids, and Inhibit Accelerated Atherosclerosis in Diabetic LDL Receptor–Deficient Mice
Mengwei Zang; Shanqin Xu; Karlene A. Maitland-Toolan; Adriana Zuccollo; Xiuyun Hou; Bingbing Jiang; Michel Wierzbicki; Tony J. Verbeuren; Richard A. Cohen
Diabetes August 2006, Vol.55, 2180-2191. doi:https://doi.org/10.2337/db05-1188
Free Fatty Acids Inhibit Insulin Signaling–Stimulated Endothelial Nitric Oxide Synthase Activation Through Upregulating PTEN or Inhibiting Akt Kinase
Xing Li Wang; Lin Zhang; Keith Youker; Ming-Xiang Zhang; Jian Wang; Scott A. LeMaire; Joseph S. Coselli; Ying H. Shen
Diabetes August 2006, Vol.55, 2301-2310. doi:https://doi.org/10.2337/db05-1574
Insulin Regulation of Skeletal Muscle PDK4 mRNA Expression Is Impaired in Acute Insulin-Resistant States
Diabetes August 2006, Vol.55, 2311-2317. doi:https://doi.org/10.2337/db05-1606
Islet Studies
Impaired NH2-Terminal Processing of Human Proislet Amyloid Polypeptide by the Prohormone Convertase PC2 Leads to Amyloid Formation and Cell Death
Lucy Marzban; Christopher J. Rhodes; Donald F. Steiner; Leena Haataja; Philippe A. Halban; C. Bruce Verchere
Diabetes August 2006, Vol.55, 2192-2201. doi:https://doi.org/10.2337/db05-1566
A Conditional Model Reveals That Induction of Hepatocyte Nuclear Factor-1α in Hnf1α-Null Mutant β-Cells Can Activate Silenced Genes Postnatally, Whereas Overexpression Is Deleterious
Reini F. Luco; Miguel A. Maestro; Natalia del Pozo; William M. Philbrick; Pablo Perez de la Ossa; Jorge Ferrer
Diabetes August 2006, Vol.55, 2202-2211. doi:https://doi.org/10.2337/db05-1534
Granzyme B–Mediated Death of Pancreatic β-Cells Requires the Proapoptotic BH3-Only Molecule Bid
Eugene Estella; Mark D. McKenzie; Tara Catterall; Vivien R. Sutton; Phillip I. Bird; Joseph A. Trapani; Thomas W. Kay; Helen E. Thomas
Diabetes August 2006, Vol.55, 2212-2219. doi:https://doi.org/10.2337/db06-0129
ERK1/2 Control Phosphorylation and Protein Level of cAMP-Responsive Element–Binding Protein : A Key Role in Glucose-Mediated Pancreatic β-Cell Survival
Safia Costes; Christophe Broca; Gyslaine Bertrand; Anne-Dominique Lajoix; Dominique Bataille; Joel Bockaert; Stéphane Dalle
Diabetes August 2006, Vol.55, 2220-2230. doi:https://doi.org/10.2337/db05-1618
Paradoxical Stimulation of Glucagon Secretion by High Glucose Concentrations
Diabetes August 2006, Vol.55, 2318-2323. doi:https://doi.org/10.2337/db06-0080
Intrahepatic Transplanted Islets in Humans Secrete Insulin in a Coordinate Pulsatile Manner Directly Into the Liver
Juris J. Meier; Irene Hong-McAtee; Ryan Galasso; Johannes D. Veldhuis; Antoinette Moran; Bernhard J. Hering; Peter C. Butler
Diabetes August 2006, Vol.55, 2324-2332. doi:https://doi.org/10.2337/db06-0069
Complications
Benfotiamine Counteracts Glucose Toxicity Effects on Endothelial Progenitor Cell Differentiation via Akt/FoxO Signaling
Valentina Marchetti; Rossella Menghini; Stefano Rizza; Alessia Vivanti; Tiziana Feccia; Davide Lauro; Akiyoshi Fukamizu; Renato Lauro; Massimo Federici
Diabetes August 2006, Vol.55, 2231-2237. doi:https://doi.org/10.2337/db06-0369
α-Lipoic Acid Prevents the Increase in Atherosclerosis Induced by Diabetes in Apolipoprotein E–Deficient Mice Fed High-Fat/Low-Cholesterol Diet
Diabetes August 2006, Vol.55, 2238-2244. doi:https://doi.org/10.2337/db06-0251
Receptor for Advanced Glycation End Products Is Involved in Impaired Angiogenic Response in Diabetes
Takuhito Shoji; Hidenori Koyama; Tomoaki Morioka; Shinji Tanaka; Akane Kizu; Kohka Motoyama; Katsuhito Mori; Shinya Fukumoto; Atsushi Shioi; Noriko Shimogaito; Masayoshi Takeuchi; Yasuhiko Yamamoto; Hideto Yonekura; Hiroshi Yamamoto; Yoshiki Nishizawa
Diabetes August 2006, Vol.55, 2245-2255. doi:https://doi.org/10.2337/db05-1375
Pharmacology & Therapeutics
Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States
Yun S. Lee; Woo S. Kim; Kang H. Kim; Myung J. Yoon; Hye J. Cho; Yun Shen; Ji-Ming Ye; Chul H. Lee; Won K. Oh; Chul T. Kim; Cordula Hohnen-Behrens; Alison Gosby; Edward W. Kraegen; David E. James; Jae B. Kim
Diabetes August 2006, Vol.55, 2256-2264. doi:https://doi.org/10.2337/db06-0006
Effects of Recombinant Human IGF-I/IGF-Binding Protein-3 Complex on Glucose and Glycerol Metabolism in Type 1 Diabetes
Tero Saukkonen; Fariba Shojaee-Moradie; Rachel M. Williams; Rakesh Amin; Kevin C. Yuen; Angie Watts; Carlo L. Acerini; A. Margot Umpleby; David B. Dunger
Diabetes August 2006, Vol.55, 2365-2370. doi:https://doi.org/10.2337/db05-1646
Pioglitazone but Not Glibenclamide Improves Cardiac Expression of Heat Shock Protein 72 and Tolerance Against Ischemia/Reperfusion Injury in the Heredity Insulin-Resistant Rat
Yayoi Taniguchi; Tatsuhiko Ooie; Naohiko Takahashi; Tetsuji Shinohara; Mikiko Nakagawa; Hidetoshi Yonemochi; Masahide Hara; Hironobu Yoshimatsu; Tetsunori Saikawa
Diabetes August 2006, Vol.55, 2371-2378. doi:https://doi.org/10.2337/db06-0268
Genetics
Impact of Chromosome 2 Obesity Loci on Cardiovascular Complications of Insulin Resistance in LDL Receptor–Deficient C57BL/6 Mice
Daria Estrada-Smith; Alan R. Collins; Xuping Wang; Craig Crockett; Lawrence Castellani; Aldons J. Lusis; Richard C. Davis
Diabetes August 2006, Vol.55, 2265-2271. doi:https://doi.org/10.2337/db06-0377
Brief Genetics Reports
Assessment of the Role of Common Genetic Variation in the Transient Neonatal Diabetes Mellitus (TNDM) Region in Type 2 Diabetes : A Comparative Genomic and Tagging Single Nucleotide Polymorphism Approach
Anna L. Gloyn; Deborah J.G. Mackay; Michael N. Weedon; Mark I. McCarthy; Mark Walker; Graham Hitman; Bridget A. Knight; Katharine R. Owen; Andrew T. Hattersley; Timothy M. Frayling
Diabetes August 2006, Vol.55, 2272-2276. doi:https://doi.org/10.2337/db06-0216
Association Studies of Variants in the Genes Involved in Pancreatic β-Cell Function in Type 2 Diabetes in Japanese Subjects
Norihide Yokoi; Masao Kanamori; Yukio Horikawa; Jun Takeda; Tokio Sanke; Hiroto Furuta; Kishio Nanjo; Hiroyuki Mori; Masato Kasuga; Kazuo Hara; Takashi Kadowaki; Yukio Tanizawa; Yoshitomo Oka; Yukiko Iwami; Hisako Ohgawara; Yuichiro Yamada; Yutaka Seino; Hideki Yano; Nancy J. Cox; Susumu Seino
Diabetes August 2006, Vol.55, 2379-2386. doi:https://doi.org/10.2337/db05-1203
An IGF-I Gene Polymorphism Modifies the Risk of Diabetic Retinopathy
Ingrid Rietveld; M. Kamran Ikram; Johannes R. Vingerling; Albert Hofman; Huibert A.P. Pols; Steven W.J. Lamberts; Paulus T.V.M. de Jong; Cornelia M. van Duijn; Joop A.M.J.L. Janssen
Diabetes August 2006, Vol.55, 2387-2391. doi:https://doi.org/10.2337/db06-0021
Metabolism
Altered Skeletal Muscle Subsarcolemmal Mitochondrial Compartment During Catch-Up Fat After Caloric Restriction
Raffaella Crescenzo; Lillà Lionetti; Maria Pina Mollica; Marialuisa Ferraro; Elvira D’Andrea; Davide Mainieri; Abdul G. Dulloo; Giovanna Liverini; Susanna Iossa
Diabetes August 2006, Vol.55, 2286-2293. doi:https://doi.org/10.2337/db06-0312
Noninvasive Analysis of Hepatic Glycogen Kinetics Before and After Breakfast with Deuterated Water and Acetaminophen
John G. Jones; Ana Fagulha; Cristina Barosa; Margarida Bastos; Luisa Barros; Carla Baptista; M. Madalena Caldeira; Manuela Carvalheiro
Diabetes August 2006, Vol.55, 2294-2300. doi:https://doi.org/10.2337/db06-0304
Pathophysiology
Insulin Resistance Is Associated With Increased Serum Concentration of IGF-Binding Protein–Related Protein 1 (IGFBP-rP1/MAC25)
Abel López-Bermejo; Javad Khosravi; José Manuel Fernández-Real; Vivian Hwa; Katherine L. Pratt; Roser Casamitjana; Maria M. Garcia-Gil; Ron G. Rosenfeld; Wifredo Ricart
Diabetes August 2006, Vol.55, 2333-2339. doi:https://doi.org/10.2337/db05-1627
Systemic Immune Mediators and Lifestyle Changes in the Prevention of Type 2 Diabetes: Results From the Finnish Diabetes Prevention Study
Christian Herder; Markku Peltonen; Wolfgang Koenig; Ilka Kräft; Sylvia Müller-Scholze; Stephan Martin; Timo Lakka; Pirjo Ilanne-Parikka; Johan G. Eriksson; Helena Hämäläinen; Sirkka Keinänen-Kiukaanniemi; Timo T. Valle; Matti Uusitupa; Jaana Lindström; Hubert Kolb; Jaakko Tuomilehto; for the Finnish Diabetes Prevention Study Group
Diabetes August 2006, Vol.55, 2340-2346. doi:https://doi.org/10.2337/db05-1320
Mechanisms of Impaired Fasting Glucose and Glucose Intolerance Induced by a ∼50% Pancreatectomy
Diabetes August 2006, Vol.55, 2347-2356. doi:https://doi.org/10.2337/db06-0345
Obesity Is a Major Determinant of the Association of C-Reactive Protein Levels and the Metabolic Syndrome in Type 2 Diabetes
Steven E. Kahn; Bernard Zinman; Steven M. Haffner; M. Colleen O’Neill; Barbara G. Kravitz; Dahong Yu; Martin I. Freed; William H. Herman; Rury R. Holman; Nigel P. Jones; John M. Lachin; Giancarlo C. Viberti; the ADOPT Study Group
Diabetes August 2006, Vol.55, 2357-2364. doi:https://doi.org/10.2337/db06-0116
