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Issues
Perspectives in Diabetes
Diabetic Retinopathy: Seeing Beyond Glucose-Induced Microvascular Disease
David A. Antonetti; Alistair J. Barber; Sarah K. Bronson; Willard M. Freeman; Thomas W. Gardner; Leonard S. Jefferson; Mark Kester; Scot R. Kimball; J. Kyle Krady; Kathryn F. LaNoue; Christopher C. Norbury; Patrick G. Quinn; Lakshman Sandirasegarane; Ian A. Simpson; for the JDRF Diabetic Retinopathy Center Group
Topics:
diabetic retinopathy
,
retina
,
retinal diseases
,
insulin
,
glucose
Diabetes September 2006, Vol.55, 2401-2411. doi:https://doi.org/10.2337/db05-1635
Immunology and Transplantation
Cytotoxic T-Cells From T-Cell Receptor Transgenic NOD8.3 Mice Destroy β-Cells via the Perforin and Fas Pathways
Nadine L. Dudek; Helen E. Thomas; Lina Mariana; Robyn M. Sutherland; Janette Allison; Eugene Estella; Eveline Angstetra; Joseph A. Trapani; Pere Santamaria; Andrew M. Lew; Thomas W.H. Kay
Topics:
mice
,
perforin
,
socs1 gene
,
suppressor of cytokine signaling 1 protein
,
t-lymphocytes
Diabetes September 2006, Vol.55, 2412-2418. doi:https://doi.org/10.2337/db06-0109
In Vivo Imaging of Immune Rejection in Transplanted Pancreatic Islets
Natalia V. Evgenov; Zdravka Medarova; John Pratt; Pamela Pantazopoulos; Simone Leyting; Susan Bonner-Weir; Anna Moore
Topics:
contrast media
,
diagnostic imaging
,
endocrine pancreas
,
islets of langerhans transplantation
,
magnetic resonance imaging
Diabetes September 2006, Vol.55, 2419-2428. doi:https://doi.org/10.2337/db06-0484
Sirolimus Is Associated With Reduced Islet Engraftment and Impaired β-Cell Function
Nan Zhang; Dongming Su; Shen Qu; Tonia Tse; Rita Bottino; A.N. Balamurugan; Jing Xu; Jonathan S. Bromberg; H. Henry Dong
Diabetes September 2006, Vol.55, 2429-2436. doi:https://doi.org/10.2337/db06-0173
Analysis of T-Cell Assays to Measure Autoimmune Responses in Subjects With Type 1 Diabetes: Results of a Blinded Controlled Study
Vicki Seyfert-Margolis; Trang D. Gisler; Adam L. Asare; Richard S. Wang; H. Michael Dosch; Barbara Brooks-Worrell; George S. Eisenbarth; Jerry P. Palmer; Carla J. Greenbaum; Stephen E. Gitelman; Gerald T. Nepom; Jeffrey A. Bluestone; Kevan C. Herold
Topics:
autoantibodies
,
diabetes mellitus, type 1
,
immunoblotting
,
t-lymphocytes
,
cellular assay
Diabetes September 2006, Vol.55, 2588-2594. doi:https://doi.org/10.2337/db05-1378
Isolation and Characterization of Proinsulin-Producing Medullary Thymic Epithelial Cell Clones
Topics:
proinsulin
,
reverse transcriptase polymerase chain reaction
,
thymus gland
,
aire gene
,
thymic epithelial cells
Diabetes September 2006, Vol.55, 2595-2601. doi:https://doi.org/10.2337/db05-1651
Islet Studies
CD40–CD40 Ligand Interaction Activates Proinflammatory Pathways in Pancreatic Islets
Florencia M. Barbé-Tuana; Dagmar Klein; Hirohito Ichii; Dora M. Berman; Lane Coffey; Norma S. Kenyon; Camillo Ricordi; Ricardo L. Pastori
Topics:
cd40 antigens
,
cd40 ligand
,
cytokine
,
endocrine pancreas
,
chemokines
Diabetes September 2006, Vol.55, 2437-2445. doi:https://doi.org/10.2337/db05-1673
ATP Sensitivity of the ATP-Sensitive K+ Channel in Intact and Permeabilized Pancreatic β-Cells
Topics:
abcc8 gene
,
glucose
,
nucleotides
,
pancreas
,
toxins
Diabetes September 2006, Vol.55, 2446-2454. doi:https://doi.org/10.2337/db06-0360
Aging Correlates With Decreased β-Cell Proliferative Capacity and Enhanced Sensitivity to Apoptosis: A Potential Role for Fas and Pancreatic Duodenal Homeobox-1
Kathrin Maedler; Desiree M. Schumann; Fabienne Schulthess; José Oberholzer; Domenico Bosco; Thierry Berney; Marc Y. Donath
Topics:
apoptosis
,
glucose
,
tumor necrosis factor ligand superfamily member 6
,
pancreas
,
aging
Diabetes September 2006, Vol.55, 2455-2462. doi:https://doi.org/10.2337/db05-1586
Glucose Induces Opposite Intracellular Ca2+ Concentration Oscillatory Patterns in Identified α- and β-Cells Within Intact Human Islets of Langerhans
Ivan Quesada; Mariana G. Todorova; Paloma Alonso-Magdalena; Marta Beltrá; Everardo M. Carneiro; Franz Martin; Angel Nadal; Bernat Soria
Topics:
glucose
,
insulin
,
endocrine pancreas
,
immunocytochemistry
Diabetes September 2006, Vol.55, 2463-2469. doi:https://doi.org/10.2337/db06-0272
Fibroblast Growth Factor-21 Improves Pancreatic β-Cell Function and Survival by Activation of Extracellular Signal–Regulated Kinase 1/2 and Akt Signaling Pathways
Wolf Wente; Alexander M. Efanov; Martin Brenner; Alexei Kharitonenkov; Anja Köster; George E. Sandusky; Sabine Sewing; Iris Treinies; Heike Zitzer; Jesper Gromada
Topics:
cytokine
,
glucose
,
insulin
,
insulin secretion
,
mice
Diabetes September 2006, Vol.55, 2470-2478. doi:https://doi.org/10.2337/db05-1435
Glucose Toxicity Is Responsible for the Development of Impaired Regulation of Endogenous Glucose Production and Hepatic Glucokinase in Zucker Diabetic Fatty Rats
Topics:
glucose
,
plasma glucose
,
rats
,
insulin
,
liver
Diabetes September 2006, Vol.55, 2479-2490. doi:https://doi.org/10.2337/db05-1511
Nuclear Factor-κB Regulates β-Cell Death: A Critical Role for A20 in β-Cell Protection
David Liuwantara; Mark Elliot; Mariya W. Smith; Andrew O. Yam; Stacy N. Walters; Eliana Marino; Andy McShea; Shane T. Grey
Topics:
antiapoptotic agents
,
cytokine
,
genes
,
tumor necrosis factors
,
polymerase chain reaction
Diabetes September 2006, Vol.55, 2491-2501. doi:https://doi.org/10.2337/db06-0142
Complications
Regulation of Renal Fatty Acid and Cholesterol Metabolism, Inflammation, and Fibrosis in Akita and OVE26 Mice With Type 1 Diabetes
Topics:
kidney
,
mice
,
triglycerides
,
receptors, nuclear
,
cytokine
Diabetes September 2006, Vol.55, 2502-2509. doi:https://doi.org/10.2337/db05-0603
RAGE Control of Diabetic Nephropathy in a Mouse Model: Effects of RAGE Gene Disruption and Administration of Low–Molecular Weight Heparin
Khin-Mar Myint; Yasuhiko Yamamoto; Toshio Doi; Ichiro Kato; Ai Harashima; Hideto Yonekura; Takuo Watanabe; Harumichi Shinohara; Masayoshi Takeuchi; Koichi Tsuneyama; Noriyoshi Hashimoto; Masahide Asano; Shin Takasawa; Hiroshi Okamoto; Hiroshi Yamamoto
Topics:
diabetic nephropathy
,
kidney
,
low-molecular-weight heparin
,
mice
,
rage
Diabetes September 2006, Vol.55, 2510-2522. doi:https://doi.org/10.2337/db06-0221
Enhanced Proatherogenic Responses in Macrophages and Vascular Smooth Muscle Cells Derived From Diabetic db/db Mice
Topics:
chemokines
,
cytokine
,
macrophages
,
mice
,
muscle, smooth, vascular
Diabetes September 2006, Vol.55, 2611-2619. doi:https://doi.org/10.2337/db06-0164
Persistent Renal Hypertrophy and Faster Decline of Glomerular Filtration Rate Precede the Development of Microalbuminuria in Type 1 Diabetes
Gianpaolo Zerbini; Riccardo Bonfanti; Franco Meschi; Emilio Bognetti; Pier Luigi Paesano; Luigi Gianolli; Marialuisa Querques; Anna Maestroni; Giliola Calori; Alessandro Del Maschio; Ferruccio Fazio; Livio Luzi; Giuseppe Chiumello
Topics:
diabetes mellitus, type 1
,
glomerular filtration rate
,
kidney
,
microalbuminuria
,
hypertrophy
Diabetes September 2006, Vol.55, 2620-2625. doi:https://doi.org/10.2337/db06-0592
Pharmacology & Therapeutics
Halofenate Is a Selective Peroxisome Proliferator–Activated Receptor γ Modulator With Antidiabetic Activity
Tamara Allen; Fang Zhang; Shonna A. Moodie; L. Edward Clemens; Aaron Smith; Francine Gregoire; Andrea Bell; George E.O. Muscat; Thomas A. Gustafson
Topics:
halofenate
,
peroxisome proliferator-activated receptors
,
rosiglitazone
,
antidiabetics
,
obesity
Diabetes September 2006, Vol.55, 2523-2533. doi:https://doi.org/10.2337/db06-0618
Genetics
Common Variants in Maturity-Onset Diabetes of the Young Genes Contribute to Risk of Type 2 Diabetes in Finns
Lori L. Bonnycastle; Cristen J. Willer; Karen N. Conneely; Anne U. Jackson; Cecily P. Burrill; Richard M. Watanabe; Peter S. Chines; Narisu Narisu; Laura J. Scott; Sareena T. Enloe; Amy J. Swift; William L. Duren; Heather M. Stringham; Michael R. Erdos; Nancy L. Riebow; Thomas A. Buchanan; Timo T. Valle; Jaakko Tuomilehto; Richard N. Bergman; Karen L. Mohlke; Michael Boehnke; Francis S. Collins
Topics:
diabetes mellitus, type 2
,
genes
,
genotype determination
,
maturity onset diabetes mellitus in young
,
single nucleotide polymorphism
Diabetes September 2006, Vol.55, 2534-2540. doi:https://doi.org/10.2337/db06-0178
Variation Within the Gene Encoding the Upstream Stimulatory Factor 1 Does Not Influence Susceptibility to Type 2 Diabetes in Samples From Populations With Replicated Evidence of Linkage to Chromosome 1q
Eleftheria Zeggini; Coleen M. Damcott; Robert L. Hanson; Mohammad A. Karim; N. William Rayner; Christopher J. Groves; Leslie J. Baier; Terri C. Hale; Andrew T. Hattersley; Graham A. Hitman; Sarah E. Hunt; William C. Knowler; Braxton D. Mitchell; Maggie C.Y. Ng; Jeffrey R. O’Connell; Toni I. Pollin; Martine Vaxillaire; Mark Walker; Xiaoqin Wang; Pamela Whittaker; Kunsan Xiang; Weiping Jia; Juliana C. N. Chan; Philippe Froguel; Panos Deloukas; Alan R. Shuldiner; Steven C. Elbein; Mark I. McCarthy; for the International Type 2 Diabetes 1q Consortium
Topics:
chromosome 1q
,
diabetes mellitus, type 2
,
genes
,
hyperlipidemia, familial combined
,
quantitative trait, heritable
Diabetes September 2006, Vol.55, 2541-2548. doi:https://doi.org/10.2337/db06-0088
New Polymorphism of ENPP1 (PC-1) Is Associated With Increased Risk of Type 2 Diabetes Among Obese Individuals
Jacek Bochenski; Grzegorz Placha; Krzysztof Wanic; Maciej Malecki; Jacek Sieradzki; James H. Warram; Andrzej S. Krolewski
Topics:
diabetes mellitus, type 2
,
obesity
,
polymorphism
,
single nucleotide polymorphism
,
haplotypes
Diabetes September 2006, Vol.55, 2626-2630. doi:https://doi.org/10.2337/db06-0191
Polymorphisms in the Glucokinase-Associated, Dual-Specificity Phosphatase 12 (DUSP12) Gene Under Chromosome 1q21 Linkage Peak Are Associated With Type 2 Diabetes
Swapan Kumar Das; Winston S. Chu; Terri C. Hale; Xiaoqin Wang; Rebekah L. Craig; Hua Wang; Alan R. Shuldiner; Philippe Froguel; Panos Deloukas; Mark I. McCarthy; Eleftheria Zeggini; Sandra J. Hasstedt; Steven C. Elbein
Topics:
diabetes mellitus, type 2
,
genes
,
single nucleotide polymorphism
,
alleles
,
haplotypes
Diabetes September 2006, Vol.55, 2631-2639. doi:https://doi.org/10.2337/db05-1369
Brief Genetics Reports
Heterozygosity for a POMC-Null Mutation and Increased Obesity Risk in Humans
I. Sadaf Farooqi; Stenvert Drop; Agnes Clements; Julia M. Keogh; Joanna Biernacka; Sarah Lowenbein; Benjamin G. Challis; Stephen O’Rahilly
Topics:
heterozygote
,
mutation
,
obesity
,
pro-opiomelanocortin
,
overweight
Diabetes September 2006, Vol.55, 2549-2553. doi:https://doi.org/10.2337/db06-0214
Association Analysis of 6,736 U.K. Subjects Provides Replication and Confirms TCF7L2 as a Type 2 Diabetes Susceptibility Gene With a Substantial Effect on Individual Risk
Christopher J. Groves; Eleftheria Zeggini; Jayne Minton; Timothy M. Frayling; Michael N. Weedon; Nigel W. Rayner; Graham A. Hitman; Mark Walker; Steven Wiltshire; Andrew T. Hattersley; Mark I. McCarthy
Topics:
diabetes mellitus, type 2
,
genes
,
tcf7l2 gene
,
single nucleotide polymorphism
,
genotype
Diabetes September 2006, Vol.55, 2640-2644. doi:https://doi.org/10.2337/db06-0355
Variant of Transcription Factor 7-Like 2 (TCF7L2) Gene and the Risk of Type 2 Diabetes in Large Cohorts of U.S. Women and Men
Topics:
diabetes mellitus, type 2
,
tcf7l2 gene
,
genes
,
hpfs trial
Diabetes September 2006, Vol.55, 2645-2648. doi:https://doi.org/10.2337/db06-0643
Association of Transcription Factor 7-Like 2 (TCF7L2) Variants With Type 2 Diabetes in a Finnish Sample
Laura J. Scott; Lori L. Bonnycastle; Cristen J. Willer; Andrew G. Sprau; Anne U. Jackson; Narisu Narisu; William L. Duren; Peter S. Chines; Heather M. Stringham; Michael R. Erdos; Timo T. Valle; Jaakko Tuomilehto; Richard N. Bergman; Karen L. Mohlke; Francis S. Collins; Michael Boehnke
Topics:
diabetes mellitus, type 2
,
finnish
,
single nucleotide polymorphism
,
tcf7l2 gene
,
alleles
Diabetes September 2006, Vol.55, 2649-2653. doi:https://doi.org/10.2337/db06-0341
Polymorphisms in the Transcription Factor 7-Like 2 (TCF7L2) Gene Are Associated With Type 2 Diabetes in the Amish: Replication and Evidence for a Role in Both Insulin Secretion and Insulin Resistance
Coleen M. Damcott; Toni I. Pollin; Laurie J. Reinhart; Sandra H. Ott; Haiqing Shen; Kristi D. Silver; Braxton D. Mitchell; Alan R. Shuldiner
Topics:
diabetes mellitus, type 2
,
genes
,
glucose
,
insulin
,
insulin resistance
Diabetes September 2006, Vol.55, 2654-2659. doi:https://doi.org/10.2337/db06-0338
A Disease Haplotype for Advanced Nephropathy in Type 2 Diabetes at the ACE Locus
Topics:
diabetes mellitus, type 2
,
diabetic nephropathy
,
haplotypes
,
kidney diseases
,
kidney failure, chronic
Diabetes September 2006, Vol.55, 2660-2663. doi:https://doi.org/10.2337/db06-0496
Metabolism
Exercise Improves Insulin and Leptin Sensitivity in Hypothalamus of Wistar Rats
Marcelo B.S. Flores; Maria Fernanda A. Fernandes; Eduardo R. Ropelle; Marcel C. Faria; Mirian Ueno; Lício A. Velloso; Mario J.A. Saad; José B.C. Carvalheira
Topics:
1-phosphatidylinositol 3-kinase
,
hypothalamus
,
insulin
,
leptin
,
rats
Diabetes September 2006, Vol.55, 2554-2561. doi:https://doi.org/10.2337/db05-1622
Signal Transduction
Adiponectin Increases Fatty Acid Oxidation in Skeletal Muscle Cells by Sequential Activation of AMP-Activated Protein Kinase, p38 Mitogen-Activated Protein Kinase, and Peroxisome Proliferator–Activated Receptor α
Topics:
adiponectin
,
ampk
,
fatty acid oxidation
,
mitogen-activated protein kinase p38
,
ppar alpha
Diabetes September 2006, Vol.55, 2562-2570. doi:https://doi.org/10.2337/db05-1322
Obesity Studies
Fat Depot–Specific Characteristics Are Retained in Strains Derived From Single Human Preadipocytes
Tamara Tchkonia; Nino Giorgadze; Tamar Pirtskhalava; Thomas Thomou; Matthew DePonte; Ada Koo; R. Armour Forse; Dharmaraj Chinnappan; Carmen Martin-Ruiz; Thomas von Zglinicki; James L. Kirkland
Diabetes September 2006, Vol.55, 2571-2578. doi:https://doi.org/10.2337/db06-0540
Altered Adipose and Plasma Sphingolipid Metabolism in Obesity: A Potential Mechanism for Cardiovascular and Metabolic Risk
Topics:
adipose tissue
,
ceramides
,
mice
,
obesity
,
sphingolipids
Diabetes September 2006, Vol.55, 2579-2587. doi:https://doi.org/10.2337/db06-0330
Pathophysiology
Expression of Hypothalamic KiSS-1 System and Rescue of Defective Gonadotropic Responses by Kisspeptin in Streptozotocin-Induced Diabetic Male Rats
Juan M. Castellano; Victor M. Navarro; Rafael Fernández-Fernández; Juan Roa; Eva Vigo; Rafael Pineda; Carlos Dieguez; Enrique Aguilar; Leonor Pinilla; Manuel Tena-Sempere
Topics:
hypothalamus
,
kiss1 gene
,
rats
,
streptozocin
,
leptin
Diabetes September 2006, Vol.55, 2602-2610. doi:https://doi.org/10.2337/db05-1584
Retraction
Retraction
Topics:
3-nitrotyrosine
,
diabetes mellitus, type 1
,
high pressure liquid chromatography procedure
,
liquid chromatography
,
mass spectrometry
Diabetes September 2006, Vol.55, 2664. doi:https://doi.org/10.2337/db06-rt09
Erratum
Errata
Topics:
angiogenesis inhibitors
,
dentistry
,
diabetes mellitus, type 2
,
diabetic nephropathy
,
electronic
Diabetes September 2006, Vol.55, 2665. doi:https://doi.org/10.2337/db06-er09