Issues

Topics: diabetic retinopathy , retina , retinal diseases , insulin , glucose

Diabetes September 2006, Vol.55, 2401-2411. doi:https://doi.org/10.2337/db05-1635

Immunology and Transplantation

Cytotoxic T-Cells From T-Cell Receptor Transgenic NOD8.3 Mice Destroy β-Cells via the Perforin and Fas Pathways

Nadine L. Dudek; Helen E. Thomas; Lina Mariana; Robyn M. Sutherland; Janette Allison; Eugene Estella; Eveline Angstetra; Joseph A. Trapani; Pere Santamaria; Andrew M. Lew; Thomas W.H. Kay

Abstracts

Topics: mice , perforin , socs1 gene , suppressor of cytokine signaling 1 protein , t-lymphocytes

Diabetes September 2006, Vol.55, 2412-2418. doi:https://doi.org/10.2337/db06-0109

In Vivo Imaging of Immune Rejection in Transplanted Pancreatic Islets

Natalia V. Evgenov; Zdravka Medarova; John Pratt; Pamela Pantazopoulos; Simone Leyting; Susan Bonner-Weir; Anna Moore

Abstracts

Topics: contrast media , diagnostic imaging , endocrine pancreas , islets of langerhans transplantation , magnetic resonance imaging

Diabetes September 2006, Vol.55, 2419-2428. doi:https://doi.org/10.2337/db06-0484

Sirolimus Is Associated With Reduced Islet Engraftment and Impaired β-Cell Function

Nan Zhang; Dongming Su; Shen Qu; Tonia Tse; Rita Bottino; A.N. Balamurugan; Jing Xu; Jonathan S. Bromberg; H. Henry Dong

Abstracts

Topics: mice , rapamycin , insulin , glucose

Diabetes September 2006, Vol.55, 2429-2436. doi:https://doi.org/10.2337/db06-0173

Analysis of T-Cell Assays to Measure Autoimmune Responses in Subjects With Type 1 Diabetes: Results of a Blinded Controlled Study

Vicki Seyfert-Margolis; Trang D. Gisler; Adam L. Asare; Richard S. Wang; H. Michael Dosch; Barbara Brooks-Worrell; George S. Eisenbarth; Jerry P. Palmer; Carla J. Greenbaum; Stephen E. Gitelman; Gerald T. Nepom; Jeffrey A. Bluestone; Kevan C. Herold

Abstracts

Topics: autoantibodies , diabetes mellitus, type 1 , immunoblotting , t-lymphocytes , cellular assay

Diabetes September 2006, Vol.55, 2588-2594. doi:https://doi.org/10.2337/db05-1378

Isolation and Characterization of Proinsulin-Producing Medullary Thymic Epithelial Cell Clones

Michael O. Palumbo; Dina Levi; Aziz Alami Chentoufi; Constantin Polychronakos

Abstracts

Topics: proinsulin , reverse transcriptase polymerase chain reaction , thymus gland , aire gene , thymic epithelial cells

Diabetes September 2006, Vol.55, 2595-2601. doi:https://doi.org/10.2337/db05-1651

Islet Studies

CD40–CD40 Ligand Interaction Activates Proinflammatory Pathways in Pancreatic Islets

Florencia M. Barbé-Tuana; Dagmar Klein; Hirohito Ichii; Dora M. Berman; Lane Coffey; Norma S. Kenyon; Camillo Ricordi; Ricardo L. Pastori

Abstracts

Topics: cd40 antigens , cd40 ligand , cytokine , endocrine pancreas , chemokines

Diabetes September 2006, Vol.55, 2437-2445. doi:https://doi.org/10.2337/db05-1673

ATP Sensitivity of the ATP-Sensitive K⁺ Channel in Intact and Permeabilized Pancreatic β-Cells

Andrei I. Tarasov; Christophe A.J. Girard; Frances M. Ashcroft

Abstracts

Topics: abcc8 gene , glucose , nucleotides , pancreas , toxins

Diabetes September 2006, Vol.55, 2446-2454. doi:https://doi.org/10.2337/db06-0360

Aging Correlates With Decreased β-Cell Proliferative Capacity and Enhanced Sensitivity to Apoptosis: A Potential Role for Fas and Pancreatic Duodenal Homeobox-1

Kathrin Maedler; Desiree M. Schumann; Fabienne Schulthess; José Oberholzer; Domenico Bosco; Thierry Berney; Marc Y. Donath

Abstracts

Topics: apoptosis , glucose , tumor necrosis factor ligand superfamily member 6 , pancreas , aging

Diabetes September 2006, Vol.55, 2455-2462. doi:https://doi.org/10.2337/db05-1586

Glucose Induces Opposite Intracellular Ca²⁺ Concentration Oscillatory Patterns in Identified α- and β-Cells Within Intact Human Islets of Langerhans

Ivan Quesada; Mariana G. Todorova; Paloma Alonso-Magdalena; Marta Beltrá; Everardo M. Carneiro; Franz Martin; Angel Nadal; Bernat Soria

Abstracts

Topics: glucose , insulin , endocrine pancreas , immunocytochemistry

Diabetes September 2006, Vol.55, 2463-2469. doi:https://doi.org/10.2337/db06-0272

Fibroblast Growth Factor-21 Improves Pancreatic β-Cell Function and Survival by Activation of Extracellular Signal–Regulated Kinase 1/2 and Akt Signaling Pathways

Wolf Wente; Alexander M. Efanov; Martin Brenner; Alexei Kharitonenkov; Anja Köster; George E. Sandusky; Sabine Sewing; Iris Treinies; Heike Zitzer; Jesper Gromada

Abstracts

Topics: cytokine , glucose , insulin , insulin secretion , mice

Diabetes September 2006, Vol.55, 2470-2478. doi:https://doi.org/10.2337/db05-1435

Glucose Toxicity Is Responsible for the Development of Impaired Regulation of Endogenous Glucose Production and Hepatic Glucokinase in Zucker Diabetic Fatty Rats

Yuka Fujimoto; Tracy P. Torres; E. Patrick Donahue; Masakazu Shiota

Abstracts

Topics: glucose , plasma glucose , rats , insulin , liver

Diabetes September 2006, Vol.55, 2479-2490. doi:https://doi.org/10.2337/db05-1511

Nuclear Factor-κB Regulates β-Cell Death: A Critical Role for A20 in β-Cell Protection

David Liuwantara; Mark Elliot; Mariya W. Smith; Andrew O. Yam; Stacy N. Walters; Eliana Marino; Andy McShea; Shane T. Grey

Abstracts

Topics: antiapoptotic agents , cytokine , genes , tumor necrosis factors , polymerase chain reaction

Diabetes September 2006, Vol.55, 2491-2501. doi:https://doi.org/10.2337/db06-0142

Complications

Regulation of Renal Fatty Acid and Cholesterol Metabolism, Inflammation, and Fibrosis in Akita and OVE26 Mice With Type 1 Diabetes

Gregory Proctor; Tao Jiang; Mieko Iwahashi; Zhuowei Wang; Jinping Li; Moshe Levi

Abstracts

Topics: kidney , mice , triglycerides , receptors, nuclear , cytokine

Diabetes September 2006, Vol.55, 2502-2509. doi:https://doi.org/10.2337/db05-0603

RAGE Control of Diabetic Nephropathy in a Mouse Model: Effects of RAGE Gene Disruption and Administration of Low–Molecular Weight Heparin

Khin-Mar Myint; Yasuhiko Yamamoto; Toshio Doi; Ichiro Kato; Ai Harashima; Hideto Yonekura; Takuo Watanabe; Harumichi Shinohara; Masayoshi Takeuchi; Koichi Tsuneyama; Noriyoshi Hashimoto; Masahide Asano; Shin Takasawa; Hiroshi Okamoto; Hiroshi Yamamoto

Abstracts

Topics: diabetic nephropathy , kidney , low-molecular-weight heparin , mice , rage

Diabetes September 2006, Vol.55, 2510-2522. doi:https://doi.org/10.2337/db06-0221

Enhanced Proatherogenic Responses in Macrophages and Vascular Smooth Muscle Cells Derived From Diabetic db/db Mice

Shu-lian Li; Marpadga A. Reddy; Qiangjun Cai; Li Meng; Hang Yuan; Linda Lanting; Rama Natarajan

Abstracts

Topics: chemokines , cytokine , macrophages , mice , muscle, smooth, vascular

Diabetes September 2006, Vol.55, 2611-2619. doi:https://doi.org/10.2337/db06-0164

Persistent Renal Hypertrophy and Faster Decline of Glomerular Filtration Rate Precede the Development of Microalbuminuria in Type 1 Diabetes

Gianpaolo Zerbini; Riccardo Bonfanti; Franco Meschi; Emilio Bognetti; Pier Luigi Paesano; Luigi Gianolli; Marialuisa Querques; Anna Maestroni; Giliola Calori; Alessandro Del Maschio; Ferruccio Fazio; Livio Luzi; Giuseppe Chiumello

Abstracts

Topics: diabetes mellitus, type 1 , glomerular filtration rate , kidney , microalbuminuria , hypertrophy

Diabetes September 2006, Vol.55, 2620-2625. doi:https://doi.org/10.2337/db06-0592

Pharmacology & Therapeutics

Halofenate Is a Selective Peroxisome Proliferator–Activated Receptor γ Modulator With Antidiabetic Activity

Tamara Allen; Fang Zhang; Shonna A. Moodie; L. Edward Clemens; Aaron Smith; Francine Gregoire; Andrea Bell; George E.O. Muscat; Thomas A. Gustafson

Abstracts

Topics: halofenate , peroxisome proliferator-activated receptors , rosiglitazone , antidiabetics , obesity

Diabetes September 2006, Vol.55, 2523-2533. doi:https://doi.org/10.2337/db06-0618

Genetics

Common Variants in Maturity-Onset Diabetes of the Young Genes Contribute to Risk of Type 2 Diabetes in Finns

Abstracts

Topics: diabetes mellitus, type 2 , genes , genotype determination , maturity onset diabetes mellitus in young , single nucleotide polymorphism

Diabetes September 2006, Vol.55, 2534-2540. doi:https://doi.org/10.2337/db06-0178

Variation Within the Gene Encoding the Upstream Stimulatory Factor 1 Does Not Influence Susceptibility to Type 2 Diabetes in Samples From Populations With Replicated Evidence of Linkage to Chromosome 1q

Abstracts

Topics: chromosome 1q , diabetes mellitus, type 2 , genes , hyperlipidemia, familial combined , quantitative trait, heritable

Diabetes September 2006, Vol.55, 2541-2548. doi:https://doi.org/10.2337/db06-0088

New Polymorphism of ENPP1 (PC-1) Is Associated With Increased Risk of Type 2 Diabetes Among Obese Individuals

Jacek Bochenski; Grzegorz Placha; Krzysztof Wanic; Maciej Malecki; Jacek Sieradzki; James H. Warram; Andrzej S. Krolewski

Abstracts

Topics: diabetes mellitus, type 2 , obesity , polymorphism , single nucleotide polymorphism , haplotypes

Diabetes September 2006, Vol.55, 2626-2630. doi:https://doi.org/10.2337/db06-0191

Polymorphisms in the Glucokinase-Associated, Dual-Specificity Phosphatase 12 (DUSP12) Gene Under Chromosome 1q21 Linkage Peak Are Associated With Type 2 Diabetes

Swapan Kumar Das; Winston S. Chu; Terri C. Hale; Xiaoqin Wang; Rebekah L. Craig; Hua Wang; Alan R. Shuldiner; Philippe Froguel; Panos Deloukas; Mark I. McCarthy; Eleftheria Zeggini; Sandra J. Hasstedt; Steven C. Elbein

Abstracts

Topics: diabetes mellitus, type 2 , genes , single nucleotide polymorphism , alleles , haplotypes

Diabetes September 2006, Vol.55, 2631-2639. doi:https://doi.org/10.2337/db05-1369

Brief Genetics Reports

Heterozygosity for a POMC-Null Mutation and Increased Obesity Risk in Humans

I. Sadaf Farooqi; Stenvert Drop; Agnes Clements; Julia M. Keogh; Joanna Biernacka; Sarah Lowenbein; Benjamin G. Challis; Stephen O’Rahilly

Abstracts

Topics: heterozygote , mutation , obesity , pro-opiomelanocortin , overweight

Diabetes September 2006, Vol.55, 2549-2553. doi:https://doi.org/10.2337/db06-0214

Association Analysis of 6,736 U.K. Subjects Provides Replication and Confirms TCF7L2 as a Type 2 Diabetes Susceptibility Gene With a Substantial Effect on Individual Risk

Christopher J. Groves; Eleftheria Zeggini; Jayne Minton; Timothy M. Frayling; Michael N. Weedon; Nigel W. Rayner; Graham A. Hitman; Mark Walker; Steven Wiltshire; Andrew T. Hattersley; Mark I. McCarthy

Abstracts

Topics: diabetes mellitus, type 2 , genes , tcf7l2 gene , single nucleotide polymorphism , genotype

Diabetes September 2006, Vol.55, 2640-2644. doi:https://doi.org/10.2337/db06-0355

Variant of Transcription Factor 7-Like 2 (TCF7L2) Gene and the Risk of Type 2 Diabetes in Large Cohorts of U.S. Women and Men

Cuilin Zhang; Lu Qi; David J. Hunter; James B. Meigs; JoAnn E. Manson; Rob M. van Dam; Frank B. Hu

Abstracts

Topics: diabetes mellitus, type 2 , tcf7l2 gene , genes , hpfs trial

Diabetes September 2006, Vol.55, 2645-2648. doi:https://doi.org/10.2337/db06-0643

Association of Transcription Factor 7-Like 2 (TCF7L2) Variants With Type 2 Diabetes in a Finnish Sample

Laura J. Scott; Lori L. Bonnycastle; Cristen J. Willer; Andrew G. Sprau; Anne U. Jackson; Narisu Narisu; William L. Duren; Peter S. Chines; Heather M. Stringham; Michael R. Erdos; Timo T. Valle; Jaakko Tuomilehto; Richard N. Bergman; Karen L. Mohlke; Francis S. Collins; Michael Boehnke

Abstracts

Topics: diabetes mellitus, type 2 , finnish , single nucleotide polymorphism , tcf7l2 gene , alleles

Diabetes September 2006, Vol.55, 2649-2653. doi:https://doi.org/10.2337/db06-0341

Polymorphisms in the Transcription Factor 7-Like 2 (TCF7L2) Gene Are Associated With Type 2 Diabetes in the Amish: Replication and Evidence for a Role in Both Insulin Secretion and Insulin Resistance

Coleen M. Damcott; Toni I. Pollin; Laurie J. Reinhart; Sandra H. Ott; Haiqing Shen; Kristi D. Silver; Braxton D. Mitchell; Alan R. Shuldiner

Abstracts

Topics: diabetes mellitus, type 2 , genes , glucose , insulin , insulin resistance

Diabetes September 2006, Vol.55, 2654-2659. doi:https://doi.org/10.2337/db06-0338

A Disease Haplotype for Advanced Nephropathy in Type 2 Diabetes at the ACE Locus

Daniel P.K. Ng; Grzegorz Placha; Serena Choo; Kee-seng Chia; James H. Warram; Andrzej S. Krolewski

Abstracts

Topics: diabetes mellitus, type 2 , diabetic nephropathy , haplotypes , kidney diseases , kidney failure, chronic

Diabetes September 2006, Vol.55, 2660-2663. doi:https://doi.org/10.2337/db06-0496

Metabolism

Exercise Improves Insulin and Leptin Sensitivity in Hypothalamus of Wistar Rats

Marcelo B.S. Flores; Maria Fernanda A. Fernandes; Eduardo R. Ropelle; Marcel C. Faria; Mirian Ueno; Lício A. Velloso; Mario J.A. Saad; José B.C. Carvalheira

Abstracts

Topics: 1-phosphatidylinositol 3-kinase , hypothalamus , insulin , leptin , rats

Diabetes September 2006, Vol.55, 2554-2561. doi:https://doi.org/10.2337/db05-1622

Signal Transduction

Adiponectin Increases Fatty Acid Oxidation in Skeletal Muscle Cells by Sequential Activation of AMP-Activated Protein Kinase, p38 Mitogen-Activated Protein Kinase, and Peroxisome Proliferator–Activated Receptor α

Myeong Jin Yoon; Gha Young Lee; Jun-Jae Chung; Young Ho Ahn; Seung Hwan Hong; Jae Bum Kim

Abstracts

Topics: adiponectin , ampk , fatty acid oxidation , mitogen-activated protein kinase p38 , ppar alpha

Diabetes September 2006, Vol.55, 2562-2570. doi:https://doi.org/10.2337/db05-1322

Obesity Studies

Fat Depot–Specific Characteristics Are Retained in Strains Derived From Single Human Preadipocytes

Tamara Tchkonia; Nino Giorgadze; Tamar Pirtskhalava; Thomas Thomou; Matthew DePonte; Ada Koo; R. Armour Forse; Dharmaraj Chinnappan; Carmen Martin-Ruiz; Thomas von Zglinicki; James L. Kirkland

Abstracts

Topics: abdomen , apoptosis , dna , lipids , mesentery

Diabetes September 2006, Vol.55, 2571-2578. doi:https://doi.org/10.2337/db06-0540

Altered Adipose and Plasma Sphingolipid Metabolism in Obesity: A Potential Mechanism for Cardiovascular and Metabolic Risk

Fahumiya Samad; Kelly D. Hester; Guang Yang; Yusuf A. Hannun; Jacek Bielawski

Abstracts

Topics: adipose tissue , ceramides , mice , obesity , sphingolipids

Diabetes September 2006, Vol.55, 2579-2587. doi:https://doi.org/10.2337/db06-0330

Pathophysiology

Expression of Hypothalamic KiSS-1 System and Rescue of Defective Gonadotropic Responses by Kisspeptin in Streptozotocin-Induced Diabetic Male Rats

Juan M. Castellano; Victor M. Navarro; Rafael Fernández-Fernández; Juan Roa; Eva Vigo; Rafael Pineda; Carlos Dieguez; Enrique Aguilar; Leonor Pinilla; Manuel Tena-Sempere

Abstracts

Topics: hypothalamus , kiss1 gene , rats , streptozocin , leptin

Diabetes September 2006, Vol.55, 2602-2610. doi:https://doi.org/10.2337/db05-1584

Retraction

Franz M. Matschinsky

Extract

Topics: 3-nitrotyrosine , diabetes mellitus, type 1 , high pressure liquid chromatography procedure , liquid chromatography , mass spectrometry

Diabetes September 2006, Vol.55, 2664. doi:https://doi.org/10.2337/db06-rt09

Erratum

Errata

Extract