Skip to Main Content
Umbrella Alt Text
header search
Search
Advanced Search
Skip Nav Destination

Issues

Volume 55, Issue 9
September 2006
Issue Cover
All Issues
ISSN 0012-1797
EISSN 1939-327X
Search within issue

Perspectives in Diabetes

Diabetic Retinopathy: Seeing Beyond Glucose-Induced Microvascular Disease
David A. Antonetti; Alistair J. Barber; Sarah K. Bronson; Willard M. Freeman; Thomas W. Gardner; Leonard S. Jefferson; Mark Kester; Scot R. Kimball; J. Kyle Krady; Kathryn F. LaNoue; Christopher C. Norbury; Patrick G. Quinn; Lakshman Sandirasegarane; Ian A. Simpson; for the JDRF Diabetic Retinopathy Center Group
View articletitled, Diabetic Retinopathy<span class="subtitle-colon">: </span><span class="subtitle">Seeing Beyond Glucose-Induced Microvascular Disease</span>
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2401-2411. doi:https://doi.org/10.2337/db05-1635

Immunology and Transplantation

Cytotoxic T-Cells From T-Cell Receptor Transgenic NOD8.3 Mice Destroy β-Cells via the Perforin and Fas Pathways
Nadine L. Dudek; Helen E. Thomas; Lina Mariana; Robyn M. Sutherland; Janette Allison; Eugene Estella; Eveline Angstetra; Joseph A. Trapani; Pere Santamaria; Andrew M. Lew; Thomas W.H. Kay
View articletitled, Cytotoxic T-Cells From T-Cell Receptor Transgenic NOD8.3 Mice Destroy β-Cells via the Perforin and Fas Pathways
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2412-2418. doi:https://doi.org/10.2337/db06-0109
In Vivo Imaging of Immune Rejection in Transplanted Pancreatic Islets
Natalia V. Evgenov; Zdravka Medarova; John Pratt; Pamela Pantazopoulos; Simone Leyting; Susan Bonner-Weir; Anna Moore
View articletitled, In Vivo Imaging of Immune Rejection in Transplanted Pancreatic Islets
Supplementary data
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2419-2428. doi:https://doi.org/10.2337/db06-0484
Sirolimus Is Associated With Reduced Islet Engraftment and Impaired β-Cell Function
Nan Zhang; Dongming Su; Shen Qu; Tonia Tse; Rita Bottino; A.N. Balamurugan; Jing Xu; Jonathan S. Bromberg; H. Henry Dong
View articletitled, Sirolimus Is Associated With Reduced Islet Engraftment and Impaired β-Cell Function
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2429-2436. doi:https://doi.org/10.2337/db06-0173
Analysis of T-Cell Assays to Measure Autoimmune Responses in Subjects With Type 1 Diabetes: Results of a Blinded Controlled Study
Vicki Seyfert-Margolis; Trang D. Gisler; Adam L. Asare; Richard S. Wang; H. Michael Dosch; Barbara Brooks-Worrell; George S. Eisenbarth; Jerry P. Palmer; Carla J. Greenbaum; Stephen E. Gitelman; Gerald T. Nepom; Jeffrey A. Bluestone; Kevan C. Herold
View articletitled, Analysis of T-Cell Assays to Measure Autoimmune Responses in Subjects With Type 1 Diabetes<span class="subtitle-colon">: </span><span class="subtitle">Results of a Blinded Controlled Study</span>
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2588-2594. doi:https://doi.org/10.2337/db05-1378
Isolation and Characterization of Proinsulin-Producing Medullary Thymic Epithelial Cell Clones
Michael O. Palumbo; Dina Levi; Aziz Alami Chentoufi; Constantin Polychronakos
View articletitled, Isolation and Characterization of Proinsulin-Producing Medullary Thymic Epithelial Cell Clones
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2595-2601. doi:https://doi.org/10.2337/db05-1651

Islet Studies

CD40–CD40 Ligand Interaction Activates Proinflammatory Pathways in Pancreatic Islets
Florencia M. Barbé-Tuana; Dagmar Klein; Hirohito Ichii; Dora M. Berman; Lane Coffey; Norma S. Kenyon; Camillo Ricordi; Ricardo L. Pastori
View articletitled, CD40–CD40 Ligand Interaction Activates Proinflammatory Pathways in Pancreatic Islets
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2437-2445. doi:https://doi.org/10.2337/db05-1673
ATP Sensitivity of the ATP-Sensitive K+ Channel in Intact and Permeabilized Pancreatic β-Cells
Andrei I. Tarasov; Christophe A.J. Girard; Frances M. Ashcroft
View articletitled, ATP Sensitivity of the ATP-Sensitive K<sup>+</sup> Channel in Intact and Permeabilized Pancreatic β-Cells
Supplementary data
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2446-2454. doi:https://doi.org/10.2337/db06-0360
Aging Correlates With Decreased β-Cell Proliferative Capacity and Enhanced Sensitivity to Apoptosis: A Potential Role for Fas and Pancreatic Duodenal Homeobox-1
Kathrin Maedler; Desiree M. Schumann; Fabienne Schulthess; José Oberholzer; Domenico Bosco; Thierry Berney; Marc Y. Donath
View articletitled, Aging Correlates With Decreased β-Cell Proliferative Capacity and Enhanced Sensitivity to Apoptosis<span class="subtitle-colon">: </span><span class="subtitle">A Potential Role for Fas and Pancreatic Duodenal Homeobox-1</span>
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2455-2462. doi:https://doi.org/10.2337/db05-1586
Glucose Induces Opposite Intracellular Ca2+ Concentration Oscillatory Patterns in Identified α- and β-Cells Within Intact Human Islets of Langerhans
Ivan Quesada; Mariana G. Todorova; Paloma Alonso-Magdalena; Marta Beltrá; Everardo M. Carneiro; Franz Martin; Angel Nadal; Bernat Soria
View articletitled, Glucose Induces Opposite Intracellular Ca<sup>2+</sup> Concentration Oscillatory Patterns in Identified α- and β-Cells Within Intact Human Islets of Langerhans
Supplementary data
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2463-2469. doi:https://doi.org/10.2337/db06-0272
Fibroblast Growth Factor-21 Improves Pancreatic β-Cell Function and Survival by Activation of Extracellular Signal–Regulated Kinase 1/2 and Akt Signaling Pathways
Wolf Wente; Alexander M. Efanov; Martin Brenner; Alexei Kharitonenkov; Anja Köster; George E. Sandusky; Sabine Sewing; Iris Treinies; Heike Zitzer; Jesper Gromada
View articletitled, Fibroblast Growth Factor-21 Improves Pancreatic β-Cell Function and Survival by Activation of Extracellular Signal–Regulated Kinase 1/2 and Akt Signaling Pathways
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2470-2478. doi:https://doi.org/10.2337/db05-1435
Glucose Toxicity Is Responsible for the Development of Impaired Regulation of Endogenous Glucose Production and Hepatic Glucokinase in Zucker Diabetic Fatty Rats
Yuka Fujimoto; Tracy P. Torres; E. Patrick Donahue; Masakazu Shiota
View articletitled, Glucose Toxicity Is Responsible for the Development of Impaired Regulation of Endogenous Glucose Production and Hepatic Glucokinase in Zucker Diabetic Fatty Rats
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2479-2490. doi:https://doi.org/10.2337/db05-1511
Nuclear Factor-κB Regulates β-Cell Death: A Critical Role for A20 in β-Cell Protection
David Liuwantara; Mark Elliot; Mariya W. Smith; Andrew O. Yam; Stacy N. Walters; Eliana Marino; Andy McShea; Shane T. Grey
View articletitled, Nuclear Factor-κB Regulates β-Cell Death<span class="subtitle-colon">: </span><span class="subtitle">A Critical Role for A20 in β-Cell Protection</span>
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2491-2501. doi:https://doi.org/10.2337/db06-0142

Complications

Regulation of Renal Fatty Acid and Cholesterol Metabolism, Inflammation, and Fibrosis in Akita and OVE26 Mice With Type 1 Diabetes
Gregory Proctor; Tao Jiang; Mieko Iwahashi; Zhuowei Wang; Jinping Li; Moshe Levi
View articletitled, Regulation of Renal Fatty Acid and Cholesterol Metabolism, Inflammation, and Fibrosis in Akita and OVE26 Mice With Type 1 Diabetes
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2502-2509. doi:https://doi.org/10.2337/db05-0603
RAGE Control of Diabetic Nephropathy in a Mouse Model: Effects of RAGE Gene Disruption and Administration of Low–Molecular Weight Heparin
Khin-Mar Myint; Yasuhiko Yamamoto; Toshio Doi; Ichiro Kato; Ai Harashima; Hideto Yonekura; Takuo Watanabe; Harumichi Shinohara; Masayoshi Takeuchi; Koichi Tsuneyama; Noriyoshi Hashimoto; Masahide Asano; Shin Takasawa; Hiroshi Okamoto; Hiroshi Yamamoto
View articletitled, RAGE Control of Diabetic Nephropathy in a Mouse Model<span class="subtitle-colon">: </span><span class="subtitle">Effects of <em>RAGE</em> Gene Disruption and Administration of Low–Molecular Weight Heparin</span>
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2510-2522. doi:https://doi.org/10.2337/db06-0221
Enhanced Proatherogenic Responses in Macrophages and Vascular Smooth Muscle Cells Derived From Diabetic db/db Mice
Shu-lian Li; Marpadga A. Reddy; Qiangjun Cai; Li Meng; Hang Yuan; Linda Lanting; Rama Natarajan
View articletitled, Enhanced Proatherogenic Responses in Macrophages and Vascular Smooth Muscle Cells Derived From Diabetic <em>db/db</em> Mice
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2611-2619. doi:https://doi.org/10.2337/db06-0164
Persistent Renal Hypertrophy and Faster Decline of Glomerular Filtration Rate Precede the Development of Microalbuminuria in Type 1 Diabetes
Gianpaolo Zerbini; Riccardo Bonfanti; Franco Meschi; Emilio Bognetti; Pier Luigi Paesano; Luigi Gianolli; Marialuisa Querques; Anna Maestroni; Giliola Calori; Alessandro Del Maschio; Ferruccio Fazio; Livio Luzi; Giuseppe Chiumello
View articletitled, Persistent Renal Hypertrophy and Faster Decline of Glomerular Filtration Rate Precede the Development of Microalbuminuria in Type 1 Diabetes
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2620-2625. doi:https://doi.org/10.2337/db06-0592

Pharmacology & Therapeutics

Halofenate Is a Selective Peroxisome Proliferator–Activated Receptor γ Modulator With Antidiabetic Activity
Tamara Allen; Fang Zhang; Shonna A. Moodie; L. Edward Clemens; Aaron Smith; Francine Gregoire; Andrea Bell; George E.O. Muscat; Thomas A. Gustafson
View articletitled, Halofenate Is a Selective Peroxisome Proliferator–Activated Receptor γ Modulator With Antidiabetic Activity
Supplementary data
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2523-2533. doi:https://doi.org/10.2337/db06-0618

Genetics

Common Variants in Maturity-Onset Diabetes of the Young Genes Contribute to Risk of Type 2 Diabetes in Finns
Lori L. Bonnycastle; Cristen J. Willer; Karen N. Conneely; Anne U. Jackson; Cecily P. Burrill; Richard M. Watanabe; Peter S. Chines; Narisu Narisu; Laura J. Scott; Sareena T. Enloe; Amy J. Swift; William L. Duren; Heather M. Stringham; Michael R. Erdos; Nancy L. Riebow; Thomas A. Buchanan; Timo T. Valle; Jaakko Tuomilehto; Richard N. Bergman; Karen L. Mohlke; Michael Boehnke; Francis S. Collins
View articletitled, Common Variants in Maturity-Onset Diabetes of the Young Genes Contribute to Risk of Type 2 Diabetes in Finns
Supplementary data
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2534-2540. doi:https://doi.org/10.2337/db06-0178
Variation Within the Gene Encoding the Upstream Stimulatory Factor 1 Does Not Influence Susceptibility to Type 2 Diabetes in Samples From Populations With Replicated Evidence of Linkage to Chromosome 1q
Eleftheria Zeggini; Coleen M. Damcott; Robert L. Hanson; Mohammad A. Karim; N. William Rayner; Christopher J. Groves; Leslie J. Baier; Terri C. Hale; Andrew T. Hattersley; Graham A. Hitman; Sarah E. Hunt; William C. Knowler; Braxton D. Mitchell; Maggie C.Y. Ng; Jeffrey R. O’Connell; Toni I. Pollin; Martine Vaxillaire; Mark Walker; Xiaoqin Wang; Pamela Whittaker; Kunsan Xiang; Weiping Jia; Juliana C. N. Chan; Philippe Froguel; Panos Deloukas; Alan R. Shuldiner; Steven C. Elbein; Mark I. McCarthy; for the International Type 2 Diabetes 1q Consortium
View articletitled, Variation Within the Gene Encoding the Upstream Stimulatory Factor 1 Does Not Influence Susceptibility to Type 2 Diabetes in Samples From Populations With Replicated Evidence of Linkage to Chromosome 1q
Supplementary data
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2541-2548. doi:https://doi.org/10.2337/db06-0088
New Polymorphism of ENPP1 (PC-1) Is Associated With Increased Risk of Type 2 Diabetes Among Obese Individuals
Jacek Bochenski; Grzegorz Placha; Krzysztof Wanic; Maciej Malecki; Jacek Sieradzki; James H. Warram; Andrzej S. Krolewski
View articletitled, New Polymorphism of <em>ENPP1</em> (<em>PC-1</em>) Is Associated With Increased Risk of Type 2 Diabetes Among Obese Individuals
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2626-2630. doi:https://doi.org/10.2337/db06-0191
Polymorphisms in the Glucokinase-Associated, Dual-Specificity Phosphatase 12 (DUSP12) Gene Under Chromosome 1q21 Linkage Peak Are Associated With Type 2 Diabetes
Swapan Kumar Das; Winston S. Chu; Terri C. Hale; Xiaoqin Wang; Rebekah L. Craig; Hua Wang; Alan R. Shuldiner; Philippe Froguel; Panos Deloukas; Mark I. McCarthy; Eleftheria Zeggini; Sandra J. Hasstedt; Steven C. Elbein
View articletitled, Polymorphisms in the Glucokinase-Associated, Dual-Specificity Phosphatase 12 (DUSP12) Gene Under Chromosome 1q21 Linkage Peak Are Associated With Type 2 Diabetes
Supplementary data
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2631-2639. doi:https://doi.org/10.2337/db05-1369

Brief Genetics Reports

Heterozygosity for a POMC-Null Mutation and Increased Obesity Risk in Humans
I. Sadaf Farooqi; Stenvert Drop; Agnes Clements; Julia M. Keogh; Joanna Biernacka; Sarah Lowenbein; Benjamin G. Challis; Stephen O’Rahilly
View articletitled, Heterozygosity for a <em>POMC</em>-Null Mutation and Increased Obesity Risk in Humans
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2549-2553. doi:https://doi.org/10.2337/db06-0214
Association Analysis of 6,736 U.K. Subjects Provides Replication and Confirms TCF7L2 as a Type 2 Diabetes Susceptibility Gene With a Substantial Effect on Individual Risk
Christopher J. Groves; Eleftheria Zeggini; Jayne Minton; Timothy M. Frayling; Michael N. Weedon; Nigel W. Rayner; Graham A. Hitman; Mark Walker; Steven Wiltshire; Andrew T. Hattersley; Mark I. McCarthy
View articletitled, Association Analysis of 6,736 U.K. Subjects Provides Replication and Confirms <em>TCF7L2</em> as a Type 2 Diabetes Susceptibility Gene With a Substantial Effect on Individual Risk
Supplementary data
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2640-2644. doi:https://doi.org/10.2337/db06-0355
Variant of Transcription Factor 7-Like 2 (TCF7L2) Gene and the Risk of Type 2 Diabetes in Large Cohorts of U.S. Women and Men
Cuilin Zhang; Lu Qi; David J. Hunter; James B. Meigs; JoAnn E. Manson; Rob M. van Dam; Frank B. Hu
View articletitled, Variant of Transcription Factor 7-Like 2 (<em>TCF7L2</em>) Gene and the Risk of Type 2 Diabetes in Large Cohorts of U.S. Women and Men
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2645-2648. doi:https://doi.org/10.2337/db06-0643
Association of Transcription Factor 7-Like 2 (TCF7L2) Variants With Type 2 Diabetes in a Finnish Sample
Laura J. Scott; Lori L. Bonnycastle; Cristen J. Willer; Andrew G. Sprau; Anne U. Jackson; Narisu Narisu; William L. Duren; Peter S. Chines; Heather M. Stringham; Michael R. Erdos; Timo T. Valle; Jaakko Tuomilehto; Richard N. Bergman; Karen L. Mohlke; Francis S. Collins; Michael Boehnke
View articletitled, Association of Transcription Factor 7-Like 2 (<em>TCF7L2</em>) Variants With Type 2 Diabetes in a Finnish Sample
Supplementary data
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2649-2653. doi:https://doi.org/10.2337/db06-0341
Polymorphisms in the Transcription Factor 7-Like 2 (TCF7L2) Gene Are Associated With Type 2 Diabetes in the Amish: Replication and Evidence for a Role in Both Insulin Secretion and Insulin Resistance
Coleen M. Damcott; Toni I. Pollin; Laurie J. Reinhart; Sandra H. Ott; Haiqing Shen; Kristi D. Silver; Braxton D. Mitchell; Alan R. Shuldiner
View articletitled, Polymorphisms in the Transcription Factor 7-Like 2 (<em>TCF7L2</em>) Gene Are Associated With Type 2 Diabetes in the Amish<span class="subtitle-colon">: </span><span class="subtitle">Replication and Evidence for a Role in Both Insulin Secretion and Insulin Resistance</span>
Supplementary data
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2654-2659. doi:https://doi.org/10.2337/db06-0338
A Disease Haplotype for Advanced Nephropathy in Type 2 Diabetes at the ACE Locus
Daniel P.K. Ng; Grzegorz Placha; Serena Choo; Kee-seng Chia; James H. Warram; Andrzej S. Krolewski
View articletitled, A Disease Haplotype for Advanced Nephropathy in Type 2 Diabetes at the ACE Locus
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2660-2663. doi:https://doi.org/10.2337/db06-0496

Metabolism

Exercise Improves Insulin and Leptin Sensitivity in Hypothalamus of Wistar Rats
Marcelo B.S. Flores; Maria Fernanda A. Fernandes; Eduardo R. Ropelle; Marcel C. Faria; Mirian Ueno; Lício A. Velloso; Mario J.A. Saad; José B.C. Carvalheira
View articletitled, Exercise Improves Insulin and Leptin Sensitivity in Hypothalamus of Wistar Rats
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2554-2561. doi:https://doi.org/10.2337/db05-1622

Signal Transduction

Adiponectin Increases Fatty Acid Oxidation in Skeletal Muscle Cells by Sequential Activation of AMP-Activated Protein Kinase, p38 Mitogen-Activated Protein Kinase, and Peroxisome Proliferator–Activated Receptor α
Myeong Jin Yoon; Gha Young Lee; Jun-Jae Chung; Young Ho Ahn; Seung Hwan Hong; Jae Bum Kim
View articletitled, Adiponectin Increases Fatty Acid Oxidation in Skeletal Muscle Cells by Sequential Activation of AMP-Activated Protein Kinase, p38 Mitogen-Activated Protein Kinase, and Peroxisome Proliferator–Activated Receptor α
Supplementary data
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2562-2570. doi:https://doi.org/10.2337/db05-1322

Obesity Studies

Fat Depot–Specific Characteristics Are Retained in Strains Derived From Single Human Preadipocytes
Tamara Tchkonia; Nino Giorgadze; Tamar Pirtskhalava; Thomas Thomou; Matthew DePonte; Ada Koo; R. Armour Forse; Dharmaraj Chinnappan; Carmen Martin-Ruiz; Thomas von Zglinicki; James L. Kirkland
View articletitled, Fat Depot–Specific Characteristics Are Retained in Strains Derived From Single Human Preadipocytes
Supplementary data
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2571-2578. doi:https://doi.org/10.2337/db06-0540
Altered Adipose and Plasma Sphingolipid Metabolism in Obesity: A Potential Mechanism for Cardiovascular and Metabolic Risk
Fahumiya Samad; Kelly D. Hester; Guang Yang; Yusuf A. Hannun; Jacek Bielawski
View articletitled, Altered Adipose and Plasma Sphingolipid Metabolism in Obesity<span class="subtitle-colon">: </span><span class="subtitle">A Potential Mechanism for Cardiovascular and Metabolic Risk</span>
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2579-2587. doi:https://doi.org/10.2337/db06-0330

Pathophysiology

Expression of Hypothalamic KiSS-1 System and Rescue of Defective Gonadotropic Responses by Kisspeptin in Streptozotocin-Induced Diabetic Male Rats
Juan M. Castellano; Victor M. Navarro; Rafael Fernández-Fernández; Juan Roa; Eva Vigo; Rafael Pineda; Carlos Dieguez; Enrique Aguilar; Leonor Pinilla; Manuel Tena-Sempere
View articletitled, Expression of Hypothalamic KiSS-1 System and Rescue of Defective Gonadotropic Responses by Kisspeptin in Streptozotocin-Induced Diabetic Male Rats
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2602-2610. doi:https://doi.org/10.2337/db05-1584

Retraction

Retraction
Franz M. Matschinsky
View articletitled, Retraction
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2664. doi:https://doi.org/10.2337/db06-rt09

Erratum

Errata
View articletitled, Errata
Open the PDF for in another window
Diabetes September 2006, Vol.55, 2665. doi:https://doi.org/10.2337/db06-er09
Système International (SI) Units Table
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
300-OR: Beneficial Effect of the Combination Therapy of Cagrilintide, a Dual Amylin/Calcitonin Agonist, and Tirzepatide, a Dual GLP-1/GIP Agonist, on Body Weight Loss in Obese Rats
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
  • Online ISSN 1939-327X
  • Print ISSN 0012-1797

Journals

Books

Clinical Compendia

News

Podcasts

Other

About

Resources

Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.
Accept