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Issues
Commentary
Perspectives in Diabetes
Metabolism
l-Carnosine, a Substrate of Carnosinase-1, Influences Glucose Metabolism
Sibylle Sauerhöfer; Gang Yuan; Gerald Stefan Braun; Martina Deinzer; Michael Neumaier; Norbert Gretz; Jürgen Floege; Wilhelm Kriz; Fokko van der Woude; Marcus Johannes Moeller
Diabetes October 2007, Vol.56, 2425-2432. doi:https://doi.org/10.2337/db07-0177
The Contribution of Splanchnic Fat to VLDL Triglyceride Is Greater in Insulin-Resistant Than Insulin-Sensitive Men and Women : Studies in the Postprandial State
Leanne Hodson; Alex S.T. Bickerton; Siobhán E. McQuaid; Rachel Roberts; Fredrik Karpe; Keith N. Frayn; Barbara A. Fielding
Diabetes October 2007, Vol.56, 2433-2441. doi:https://doi.org/10.2337/db07-0654
PTEN Expression Contributes to the Regulation of Muscle Protein Degradation in Diabetes
Diabetes October 2007, Vol.56, 2449-2456. doi:https://doi.org/10.2337/db06-1731
Mitochondrial Energetics in the Heart in Obesity-Related Diabetes: Direct Evidence for Increased Uncoupled Respiration and Activation of Uncoupling Proteins
Sihem Boudina; Sandra Sena; Heather Theobald; Xiaoming Sheng; Jordan J. Wright; Xia Xuan Hu; Salwa Aziz; Josie I. Johnson; Heiko Bugger; Vlad G. Zaha; E. Dale Abel
Diabetes October 2007, Vol.56, 2457-2466. doi:https://doi.org/10.2337/db07-0481
The Transcriptional Coactivator Peroxisome Proliferator–Activated Receptor (PPAR)γ Coactivator-1α and the Nuclear Receptor PPARα Control the Expression of Glycerol Kinase and Metabolism Genes Independently of PPARγ Activation in Human White Adipocytes
Anne Mazzucotelli; Nathalie Viguerie; Claire Tiraby; Jean-Sébastien Annicotte; Aline Mairal; Eva Klimcakova; Emmanuelle Lepin; Paul Delmar; Sébastien Dejean; Geneviève Tavernier; Corinne Lefort; Juan Hidalgo; Thierry Pineau; Lluis Fajas; Karine Clément; Dominique Langin
Diabetes October 2007, Vol.56, 2467-2475. doi:https://doi.org/10.2337/db06-1465
Phosphorylation Barriers to Skeletal and Cardiac Muscle Glucose Uptakes in High-Fat–Fed Mice: Studies in Mice With a 50% Reduction of Hexokinase II
Patrick T. Fueger; Robert S. Lee-Young; Jane Shearer; Deanna P. Bracy; Sami Heikkinen; Markku Laakso; Jeffrey N. Rottman; David H. Wasserman
Diabetes October 2007, Vol.56, 2476-2484. doi:https://doi.org/10.2337/db07-0532
Farnesoid X Receptor Modulates Renal Lipid Metabolism, Fibrosis, and Diabetic Nephropathy
Tao Jiang; Xiaoxin X. Wang; Pnina Scherzer; Paul Wilson; James Tallman; Hideaki Takahashi; Jinping Li; Mieko Iwahashi; Eileen Sutherland; Lois Arend; Moshe Levi
Diabetes October 2007, Vol.56, 2485-2493. doi:https://doi.org/10.2337/db06-1642
Signal Transduction
Orexins Control Intestinal Glucose Transport by Distinct Neuronal, Endocrine, and Direct Epithelial Pathways
Diabetes October 2007, Vol.56, 2494-2500. doi:https://doi.org/10.2337/db07-0614
FGFR4 Prevents Hyperlipidemia and Insulin Resistance but Underlies High-Fat Diet–Induced Fatty Liver
Diabetes October 2007, Vol.56, 2501-2510. doi:https://doi.org/10.2337/db07-0648
Obesity Studies
Deficiency of Cbl-b Gene Enhances Infiltration and Activation of Macrophages in Adipose Tissue and Causes Peripheral Insulin Resistance in Mice
Katsuya Hirasaka; Shohei Kohno; Jumpei Goto; Harumi Furochi; Kazuaki Mawatari; Nagakatsu Harada; Toshio Hosaka; Yutaka Nakaya; Kazumi Ishidoh; Toshiyuki Obata; Yousuke Ebina; Hua Gu; Shin'ichi Takeda; Kyoichi Kishi; Takeshi Nikawa
Diabetes October 2007, Vol.56, 2511-2522. doi:https://doi.org/10.2337/db06-1768
Cideb Regulates Diet-Induced Obesity, Liver Steatosis, and Insulin Sensitivity by Controlling Lipogenesis and Fatty Acid Oxidation
John Zhong Li; Jing Ye; Bofu Xue; Jingzhong Qi; Jing Zhang; Zhihong Zhou; Qing Li; Zilong Wen; Peng Li
Diabetes October 2007, Vol.56, 2523-2532. doi:https://doi.org/10.2337/db07-0040
The Adipokine Lipocalin 2 Is Regulated by Obesity and Promotes Insulin Resistance
Qing-Wu Yan; Qin Yang; Nimesh Mody; Timothy E. Graham; Chung-Hsin Hsu; Zhao Xu; Nicholas E. Houstis; Barbara B. Kahn; Evan D. Rosen
Diabetes October 2007, Vol.56, 2533-2540. doi:https://doi.org/10.2337/db07-0007
Mice Heterozygous for Tumor Necrosis Factor-α Converting Enzyme Are Protected From Obesity-Induced Insulin Resistance and Diabetes
Matteo Serino; Rossella Menghini; Loredana Fiorentino; Roberta Amoruso; Alessandro Mauriello; Davide Lauro; Paolo Sbraccia; Marta L. Hribal; Renato Lauro; Massimo Federici
Diabetes October 2007, Vol.56, 2541-2546. doi:https://doi.org/10.2337/db07-0360
Glucose Ingestion Fails to Inhibit Hypothalamic Neuronal Activity in Patients With Type 2 Diabetes
Solrun Vidarsdottir; Paul A.M. Smeets; Diane L. Eichelsheim; Matthias J.P. van Osch; Max A. Viergever; Johannes A. Romijn; Jeroen van der Grond; Hanno Pijl
Diabetes October 2007, Vol.56, 2547-2550. doi:https://doi.org/10.2337/db07-0193
Immunology and Transplantation
In Vivo Cytotoxicity of Insulin-Specific CD8+ T-Cells in HLA-A*0201 Transgenic NOD Mice
Irene Jarchum; Jason C. Baker; Tatsuya Yamada; Toshiyuki Takaki; Michele P. Marron; David V. Serreze; Teresa P. DiLorenzo
Diabetes October 2007, Vol.56, 2551-2560. doi:https://doi.org/10.2337/db07-0332
Islet Studies
Essential Role for Signal Transducer and Activator of Transcription-1 in Pancreatic β-Cell Death and Autoimmune Type 1 Diabetes of Nonobese Diabetic Mice
Sunshin Kim; Hun Sik Kim; Kun Wook Chung; Seung Hoon Oh; Jong Won Yun; Sin-Hyeog Im; Moon-Kyu Lee; Kwang-Won Kim; Myung-Shik Lee
Diabetes October 2007, Vol.56, 2561-2568. doi:https://doi.org/10.2337/db06-1372
β-Cell Mitochondria Exhibit Membrane Potential Heterogeneity That Can Be Altered by Stimulatory or Toxic Fuel Levels
Jakob D. Wikstrom; Shana M. Katzman; Hibo Mohamed; Gilad Twig; Solomon A. Graf; Emma Heart; Anthony J.A. Molina; Barbara E. Corkey; Lina Moitoso de Vargas; Nika N. Danial; Sheila Collins; Orian S. Shirihai
Diabetes October 2007, Vol.56, 2569-2578. doi:https://doi.org/10.2337/db06-0757
Interaction Between Munc13-1 and RIM Is Critical for Glucagon-Like Peptide-1–Mediated Rescue of Exocytotic Defects in Munc13-1–Deficient Pancreatic β-Cells
Diabetes October 2007, Vol.56, 2579-2588. doi:https://doi.org/10.2337/db06-1207
Pathophysiology
Meal Fatty Acid Uptake in Visceral Fat in Women
Diabetes October 2007, Vol.56, 2589-2597. doi:https://doi.org/10.2337/db07-0439
Complications
High-Fat Diet–Induced Neuropathy of Pre-Diabetes and Obesity : Effects of “Healthy” Diet and Aldose Reductase Inhibition
Irina G. Obrosova; Olga Ilnytska; Valeriy V. Lyzogubov; Ivan A. Pavlov; Nazar Mashtalir; Jerry L. Nadler; Viktor R. Drel
Diabetes October 2007, Vol.56, 2598-2608. doi:https://doi.org/10.2337/db06-1176
Pharmacology and Therapeutics
Genetics
Association of the Vitamin D Metabolism Gene CYP27B1 With Type 1 Diabetes
Rebecca Bailey; Jason D. Cooper; Lauren Zeitels; Deborah J. Smyth; Jennie H.M. Yang; Neil M. Walker; Elina Hyppönen; David B. Dunger; Elizabeth Ramos-Lopez; Klaus Badenhoop; Sergey Nejentsev; John A. Todd
Diabetes October 2007, Vol.56, 2616-2621. doi:https://doi.org/10.2337/db07-0652
The Role of Melanocortin 3 Receptor Gene in Childhood Obesity
Diabetes October 2007, Vol.56, 2622-2630. doi:https://doi.org/10.2337/db07-0225
Association Study of the Genetic Polymorphisms of the Transcription Factor 7-Like 2 (TCF7L2) Gene and Type 2 Diabetes in the Chinese Population
Yi-Cheng Chang; Tien-Jyun Chang; Yi-Der Jiang; Shan-Shan Kuo; Kuan-Ching Lee; Ken C. Chiu; Lee-Ming Chuang
Diabetes October 2007, Vol.56, 2631-2637. doi:https://doi.org/10.2337/db07-0421
Variants of the Transcription Factor 7-Like 2 (TCF7L2) Gene Are Associated With Type 2 Diabetes in an African-American Population Enriched for Nephropathy
Michèle M. Sale; Shelly G. Smith; Josyf C. Mychaleckyj; Keith L. Keene; Carl D. Langefeld; Tennille S. Leak; Pamela J. Hicks; Donald W. Bowden; Stephen S. Rich; Barry I. Freedman
Diabetes October 2007, Vol.56, 2638-2642. doi:https://doi.org/10.2337/db07-0012
A Genome-Wide Linkage Scan of Insulin Level–Derived Traits: The Amish Family Diabetes Study
Wen-Chi Hsueh; Kristi D. Silver; Toni I. Pollin; Callum J. Bell; Jeffrey R. O’Connell; Braxton D. Mitchell; Alan R. Shuldiner
Diabetes October 2007, Vol.56, 2643-2648. doi:https://doi.org/10.2337/db06-1023
Errata
Online Letters to the Editor
Comment on: Buchanan (2007) (How) Can We Prevent Type 2 Diabetes? Diabetes 56:1502–1507
Diabetes October 2007, Vol.56, e19. doi:https://doi.org/10.2337/db07-0860
