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Volume 56, Issue 10
October 2007
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ISSN 0012-1797
EISSN 1939-327X
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Commentary

Testing the Gene or Testing a Variant? : The Case of TCF7L2
Mark O. Goodarzi; Jerome I. Rotter
View articletitled, Testing the Gene or Testing a Variant? <span class="subtitle-colon">: </span><span class="subtitle">The Case of TCF7L2</span>
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Diabetes October 2007, Vol.56, 2417-2419. doi:https://doi.org/10.2337/db07-0923

Perspectives in Diabetes

Estimation of β-Cell Mass by Metabolic Tests: Necessary, but How Sufficient?
R. Paul Robertson
View articletitled, Estimation of β-Cell Mass by Metabolic Tests<span class="subtitle-colon">: </span><span class="subtitle">Necessary, but How Sufficient?</span>
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Diabetes October 2007, Vol.56, 2420-2424. doi:https://doi.org/10.2337/db07-0742

Metabolism

l-Carnosine, a Substrate of Carnosinase-1, Influences Glucose Metabolism
Sibylle Sauerhöfer; Gang Yuan; Gerald Stefan Braun; Martina Deinzer; Michael Neumaier; Norbert Gretz; Jürgen Floege; Wilhelm Kriz; Fokko van der Woude; Marcus Johannes Moeller
View articletitled, <span class="small-caps">l</span>-Carnosine, a Substrate of Carnosinase-1, Influences Glucose Metabolism
Supplementary data
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Diabetes October 2007, Vol.56, 2425-2432. doi:https://doi.org/10.2337/db07-0177
The Contribution of Splanchnic Fat to VLDL Triglyceride Is Greater in Insulin-Resistant Than Insulin-Sensitive Men and Women : Studies in the Postprandial State
Leanne Hodson; Alex S.T. Bickerton; Siobhán E. McQuaid; Rachel Roberts; Fredrik Karpe; Keith N. Frayn; Barbara A. Fielding
View articletitled, The Contribution of Splanchnic Fat to VLDL Triglyceride Is Greater in Insulin-Resistant Than Insulin-Sensitive Men and Women <span class="subtitle-colon">: </span><span class="subtitle">Studies in the Postprandial State</span>
Supplementary data
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Diabetes October 2007, Vol.56, 2433-2441. doi:https://doi.org/10.2337/db07-0654
Glucagon, in Concert With Insulin, Supports the Postabsorptive Plasma Glucose Concentration in Humans
Suzanne M. Breckenridge; Benjamin A. Cooperberg; Ana Maria Arbelaez; Bruce W. Patterson; Philip E. Cryer
View articletitled, Glucagon, in Concert With Insulin, Supports the Postabsorptive Plasma Glucose Concentration in Humans
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Diabetes October 2007, Vol.56, 2442-2448. doi:https://doi.org/10.2337/db07-0751
PTEN Expression Contributes to the Regulation of Muscle Protein Degradation in Diabetes
Zhaoyong Hu; In Hee Lee; Xiaonan Wang; Hongmiao Sheng; Liping Zhang; Jie Du; William E. Mitch
View articletitled, PTEN Expression Contributes to the Regulation of Muscle Protein Degradation in Diabetes
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Diabetes October 2007, Vol.56, 2449-2456. doi:https://doi.org/10.2337/db06-1731
Mitochondrial Energetics in the Heart in Obesity-Related Diabetes: Direct Evidence for Increased Uncoupled Respiration and Activation of Uncoupling Proteins
Sihem Boudina; Sandra Sena; Heather Theobald; Xiaoming Sheng; Jordan J. Wright; Xia Xuan Hu; Salwa Aziz; Josie I. Johnson; Heiko Bugger; Vlad G. Zaha; E. Dale Abel
View articletitled, Mitochondrial Energetics in the Heart in Obesity-Related Diabetes<span class="subtitle-colon">: </span><span class="subtitle">Direct Evidence for Increased Uncoupled Respiration and Activation of Uncoupling Proteins</span>
Supplementary data
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Diabetes October 2007, Vol.56, 2457-2466. doi:https://doi.org/10.2337/db07-0481
The Transcriptional Coactivator Peroxisome Proliferator–Activated Receptor (PPAR)γ Coactivator-1α and the Nuclear Receptor PPARα Control the Expression of Glycerol Kinase and Metabolism Genes Independently of PPARγ Activation in Human White Adipocytes
Anne Mazzucotelli; Nathalie Viguerie; Claire Tiraby; Jean-Sébastien Annicotte; Aline Mairal; Eva Klimcakova; Emmanuelle Lepin; Paul Delmar; Sébastien Dejean; Geneviève Tavernier; Corinne Lefort; Juan Hidalgo; Thierry Pineau; Lluis Fajas; Karine Clément; Dominique Langin
View articletitled, The Transcriptional Coactivator Peroxisome Proliferator–Activated Receptor (PPAR)γ Coactivator-1α and the Nuclear Receptor PPARα Control the Expression of Glycerol Kinase and Metabolism Genes Independently of PPARγ Activation in Human White Adipocytes
Supplementary data
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Diabetes October 2007, Vol.56, 2467-2475. doi:https://doi.org/10.2337/db06-1465
Phosphorylation Barriers to Skeletal and Cardiac Muscle Glucose Uptakes in High-Fat–Fed Mice: Studies in Mice With a 50% Reduction of Hexokinase II
Patrick T. Fueger; Robert S. Lee-Young; Jane Shearer; Deanna P. Bracy; Sami Heikkinen; Markku Laakso; Jeffrey N. Rottman; David H. Wasserman
View articletitled, Phosphorylation Barriers to Skeletal and Cardiac Muscle Glucose Uptakes in High-Fat–Fed Mice<span class="subtitle-colon">: </span><span class="subtitle">Studies in Mice With a 50% Reduction of Hexokinase II</span>
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Diabetes October 2007, Vol.56, 2476-2484. doi:https://doi.org/10.2337/db07-0532
Farnesoid X Receptor Modulates Renal Lipid Metabolism, Fibrosis, and Diabetic Nephropathy
Tao Jiang; Xiaoxin X. Wang; Pnina Scherzer; Paul Wilson; James Tallman; Hideaki Takahashi; Jinping Li; Mieko Iwahashi; Eileen Sutherland; Lois Arend; Moshe Levi
View articletitled, Farnesoid X Receptor Modulates Renal Lipid Metabolism, Fibrosis, and Diabetic Nephropathy
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Diabetes October 2007, Vol.56, 2485-2493. doi:https://doi.org/10.2337/db06-1642

Signal Transduction

Orexins Control Intestinal Glucose Transport by Distinct Neuronal, Endocrine, and Direct Epithelial Pathways
Robert Ducroc; Thierry Voisin; Aadil El Firar; Marc Laburthe
View articletitled, Orexins Control Intestinal Glucose Transport by Distinct Neuronal, Endocrine, and Direct Epithelial Pathways
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Diabetes October 2007, Vol.56, 2494-2500. doi:https://doi.org/10.2337/db07-0614
FGFR4 Prevents Hyperlipidemia and Insulin Resistance but Underlies High-Fat Diet–Induced Fatty Liver
Xinqiang Huang; Chaofeng Yang; Yongde Luo; Chengliu Jin; Fen Wang; Wallace L. McKeehan
View articletitled, FGFR4 Prevents Hyperlipidemia and Insulin Resistance but Underlies High-Fat Diet–Induced Fatty Liver
Supplementary data
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Diabetes October 2007, Vol.56, 2501-2510. doi:https://doi.org/10.2337/db07-0648

Obesity Studies

Deficiency of Cbl-b Gene Enhances Infiltration and Activation of Macrophages in Adipose Tissue and Causes Peripheral Insulin Resistance in Mice
Katsuya Hirasaka; Shohei Kohno; Jumpei Goto; Harumi Furochi; Kazuaki Mawatari; Nagakatsu Harada; Toshio Hosaka; Yutaka Nakaya; Kazumi Ishidoh; Toshiyuki Obata; Yousuke Ebina; Hua Gu; Shin'ichi Takeda; Kyoichi Kishi; Takeshi Nikawa
View articletitled, Deficiency of <em>Cbl-b</em> Gene Enhances Infiltration and Activation of Macrophages in Adipose Tissue and Causes Peripheral Insulin Resistance in Mice
Supplementary data
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Diabetes October 2007, Vol.56, 2511-2522. doi:https://doi.org/10.2337/db06-1768
Cideb Regulates Diet-Induced Obesity, Liver Steatosis, and Insulin Sensitivity by Controlling Lipogenesis and Fatty Acid Oxidation
John Zhong Li; Jing Ye; Bofu Xue; Jingzhong Qi; Jing Zhang; Zhihong Zhou; Qing Li; Zilong Wen; Peng Li
View articletitled, Cideb Regulates Diet-Induced Obesity, Liver Steatosis, and Insulin Sensitivity by Controlling Lipogenesis and Fatty Acid Oxidation
Supplementary data
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Diabetes October 2007, Vol.56, 2523-2532. doi:https://doi.org/10.2337/db07-0040
The Adipokine Lipocalin 2 Is Regulated by Obesity and Promotes Insulin Resistance
Qing-Wu Yan; Qin Yang; Nimesh Mody; Timothy E. Graham; Chung-Hsin Hsu; Zhao Xu; Nicholas E. Houstis; Barbara B. Kahn; Evan D. Rosen
View articletitled, The Adipokine Lipocalin 2 Is Regulated by Obesity and Promotes Insulin Resistance
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Diabetes October 2007, Vol.56, 2533-2540. doi:https://doi.org/10.2337/db07-0007
Mice Heterozygous for Tumor Necrosis Factor-α Converting Enzyme Are Protected From Obesity-Induced Insulin Resistance and Diabetes
Matteo Serino; Rossella Menghini; Loredana Fiorentino; Roberta Amoruso; Alessandro Mauriello; Davide Lauro; Paolo Sbraccia; Marta L. Hribal; Renato Lauro; Massimo Federici
View articletitled, Mice Heterozygous for Tumor Necrosis Factor-α Converting Enzyme Are Protected From Obesity-Induced Insulin Resistance and Diabetes
Supplementary data
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Diabetes October 2007, Vol.56, 2541-2546. doi:https://doi.org/10.2337/db07-0360
Glucose Ingestion Fails to Inhibit Hypothalamic Neuronal Activity in Patients With Type 2 Diabetes
Solrun Vidarsdottir; Paul A.M. Smeets; Diane L. Eichelsheim; Matthias J.P. van Osch; Max A. Viergever; Johannes A. Romijn; Jeroen van der Grond; Hanno Pijl
View articletitled, Glucose Ingestion Fails to Inhibit Hypothalamic Neuronal Activity in Patients With Type 2 Diabetes
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Diabetes October 2007, Vol.56, 2547-2550. doi:https://doi.org/10.2337/db07-0193

Immunology and Transplantation

In Vivo Cytotoxicity of Insulin-Specific CD8+ T-Cells in HLA-A*0201 Transgenic NOD Mice
Irene Jarchum; Jason C. Baker; Tatsuya Yamada; Toshiyuki Takaki; Michele P. Marron; David V. Serreze; Teresa P. DiLorenzo
View articletitled, In Vivo Cytotoxicity of Insulin-Specific CD8<sup>+</sup> T-Cells in HLA-A*0201 Transgenic NOD Mice
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Diabetes October 2007, Vol.56, 2551-2560. doi:https://doi.org/10.2337/db07-0332

Islet Studies

Essential Role for Signal Transducer and Activator of Transcription-1 in Pancreatic β-Cell Death and Autoimmune Type 1 Diabetes of Nonobese Diabetic Mice
Sunshin Kim; Hun Sik Kim; Kun Wook Chung; Seung Hoon Oh; Jong Won Yun; Sin-Hyeog Im; Moon-Kyu Lee; Kwang-Won Kim; Myung-Shik Lee
View articletitled, Essential Role for Signal Transducer and Activator of Transcription-1 in Pancreatic β-Cell Death and Autoimmune Type 1 Diabetes of Nonobese Diabetic Mice
Supplementary data
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Diabetes October 2007, Vol.56, 2561-2568. doi:https://doi.org/10.2337/db06-1372
β-Cell Mitochondria Exhibit Membrane Potential Heterogeneity That Can Be Altered by Stimulatory or Toxic Fuel Levels
Jakob D. Wikstrom; Shana M. Katzman; Hibo Mohamed; Gilad Twig; Solomon A. Graf; Emma Heart; Anthony J.A. Molina; Barbara E. Corkey; Lina Moitoso de Vargas; Nika N. Danial; Sheila Collins; Orian S. Shirihai
View articletitled, β-Cell Mitochondria Exhibit Membrane Potential Heterogeneity That Can Be Altered by Stimulatory or Toxic Fuel Levels
Supplementary data
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Diabetes October 2007, Vol.56, 2569-2578. doi:https://doi.org/10.2337/db06-0757
Interaction Between Munc13-1 and RIM Is Critical for Glucagon-Like Peptide-1–Mediated Rescue of Exocytotic Defects in Munc13-1–Deficient Pancreatic β-Cells
Edwin P. Kwan; Li Xie; Laura Sheu; Toshihisa Ohtsuka; Herbert Y. Gaisano
View articletitled, Interaction Between Munc13-1 and RIM Is Critical for Glucagon-Like Peptide-1–Mediated Rescue of Exocytotic Defects in Munc13-1–Deficient Pancreatic β-Cells
Supplementary data
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Diabetes October 2007, Vol.56, 2579-2588. doi:https://doi.org/10.2337/db06-1207

Pathophysiology

Meal Fatty Acid Uptake in Visceral Fat in Women
Susanne B. Votruba; Rebecca S. Mattison; Daniel A. Dumesic; Christina Koutsari; Michael D. Jensen
View articletitled, Meal Fatty Acid Uptake in Visceral Fat in Women
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Diabetes October 2007, Vol.56, 2589-2597. doi:https://doi.org/10.2337/db07-0439

Complications

High-Fat Diet–Induced Neuropathy of Pre-Diabetes and Obesity : Effects of “Healthy” Diet and Aldose Reductase Inhibition
Irina G. Obrosova; Olga Ilnytska; Valeriy V. Lyzogubov; Ivan A. Pavlov; Nazar Mashtalir; Jerry L. Nadler; Viktor R. Drel
View articletitled, High-Fat Diet–Induced Neuropathy of Pre-Diabetes and Obesity <span class="subtitle-colon">: </span><span class="subtitle">Effects of “Healthy” Diet and Aldose Reductase Inhibition</span>
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Diabetes October 2007, Vol.56, 2598-2608. doi:https://doi.org/10.2337/db06-1176

Pharmacology and Therapeutics

The Peroxisome Proliferator–Activated Receptor-γ Agonist Pioglitazone Increases Number and Function of Endothelial Progenitor Cells in Patients With Coronary Artery Disease and Normal Glucose Tolerance
Christian Werner; Christel Hermann Kamani; Christoph Gensch; Michael Böhm; Ulrich Laufs
View articletitled, The Peroxisome Proliferator–Activated Receptor-γ Agonist Pioglitazone Increases Number and Function of Endothelial Progenitor Cells in Patients With Coronary Artery Disease and Normal Glucose Tolerance
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Diabetes October 2007, Vol.56, 2609-2615. doi:https://doi.org/10.2337/db07-0069

Genetics

Association of the Vitamin D Metabolism Gene CYP27B1 With Type 1 Diabetes
Rebecca Bailey; Jason D. Cooper; Lauren Zeitels; Deborah J. Smyth; Jennie H.M. Yang; Neil M. Walker; Elina Hyppönen; David B. Dunger; Elizabeth Ramos-Lopez; Klaus Badenhoop; Sergey Nejentsev; John A. Todd
View articletitled, Association of the Vitamin D Metabolism Gene <em>CYP27B1</em> With Type 1 Diabetes
Supplementary data
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Diabetes October 2007, Vol.56, 2616-2621. doi:https://doi.org/10.2337/db07-0652
The Role of Melanocortin 3 Receptor Gene in Childhood Obesity
Yung Seng Lee; Larry Kok Seng Poh; Betty Lay Kee Kek; Kah Yin Loke
View articletitled, The Role of Melanocortin 3 Receptor Gene in Childhood Obesity
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Diabetes October 2007, Vol.56, 2622-2630. doi:https://doi.org/10.2337/db07-0225
Association Study of the Genetic Polymorphisms of the Transcription Factor 7-Like 2 (TCF7L2) Gene and Type 2 Diabetes in the Chinese Population
Yi-Cheng Chang; Tien-Jyun Chang; Yi-Der Jiang; Shan-Shan Kuo; Kuan-Ching Lee; Ken C. Chiu; Lee-Ming Chuang
View articletitled, Association Study of the Genetic Polymorphisms of the Transcription Factor 7-Like 2 (<em>TCF7L2</em>) Gene and Type 2 Diabetes in the Chinese Population
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Diabetes October 2007, Vol.56, 2631-2637. doi:https://doi.org/10.2337/db07-0421
Variants of the Transcription Factor 7-Like 2 (TCF7L2) Gene Are Associated With Type 2 Diabetes in an African-American Population Enriched for Nephropathy
Michèle M. Sale; Shelly G. Smith; Josyf C. Mychaleckyj; Keith L. Keene; Carl D. Langefeld; Tennille S. Leak; Pamela J. Hicks; Donald W. Bowden; Stephen S. Rich; Barry I. Freedman
View articletitled, Variants of the Transcription Factor 7-Like 2 (TCF7L2) Gene Are Associated With Type 2 Diabetes in an African-American Population Enriched for Nephropathy
Supplementary data
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Diabetes October 2007, Vol.56, 2638-2642. doi:https://doi.org/10.2337/db07-0012
A Genome-Wide Linkage Scan of Insulin Level–Derived Traits: The Amish Family Diabetes Study
Wen-Chi Hsueh; Kristi D. Silver; Toni I. Pollin; Callum J. Bell; Jeffrey R. O’Connell; Braxton D. Mitchell; Alan R. Shuldiner
View articletitled, A Genome-Wide Linkage Scan of Insulin Level–Derived Traits<span class="subtitle-colon">: </span><span class="subtitle">The Amish Family Diabetes Study</span>
Supplementary data
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Diabetes October 2007, Vol.56, 2643-2648. doi:https://doi.org/10.2337/db06-1023

Errata

Errata
View articletitled, Errata
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Diabetes October 2007, Vol.56, 2649. doi:https://doi.org/10.2337/db07-er10
Errata
View articletitled, Errata
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Diabetes October 2007, Vol.56, 2649. doi:https://doi.org/10.2337/db07-er10a
ERRATA
View articletitled, ERRATA
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Diabetes October 2007, Vol.56, 2650. doi:https://doi.org/10.2337/db07-er10b
ERRATA
View articletitled, ERRATA
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Diabetes October 2007, Vol.56, 2650. doi:https://doi.org/10.2337/db07-er10c

Online Letters to the Editor

Response to Comment on: Harmancey et al. (2007) Adrenomedullin Inhibits Adipogenesis Under Transcriptional Control of Insulin: Diabetes 56:553–563
Romain Harmancey; Fatima Smih
View articletitled, Response to Comment on: Harmancey et al. (2007) Adrenomedullin Inhibits Adipogenesis Under Transcriptional Control of Insulin: <em>Diabetes</em> 56:553–563
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Diabetes October 2007, Vol.56, e18. doi:https://doi.org/10.2337/db07-1003
Comment on: Buchanan (2007) (How) Can We Prevent Type 2 Diabetes? Diabetes 56:1502–1507
Lawrence S. Phillips
View articletitled, Comment on: Buchanan (2007) (How) Can We Prevent Type 2 Diabetes? Diabetes 56:1502–1507
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Diabetes October 2007, Vol.56, e19. doi:https://doi.org/10.2337/db07-0860
Système International (SI) Units Table
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
300-OR: Beneficial Effect of the Combination Therapy of Cagrilintide, a Dual Amylin/Calcitonin Agonist, and Tirzepatide, a Dual GLP-1/GIP Agonist, on Body Weight Loss in Obese Rats
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
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