Issues

Topics: diabetes mellitus, type 2 , genes , single nucleotide polymorphism , tcf7l2 gene

Diabetes October 2007, Vol.56, 2417-2419. doi:https://doi.org/10.2337/db07-0923

Perspectives in Diabetes

Estimation of β-Cell Mass by Metabolic Tests: Necessary, but How Sufficient?

R. Paul Robertson

Abstracts

Topics: glucose , metabolic tests , insulin

Diabetes October 2007, Vol.56, 2420-2424. doi:https://doi.org/10.2337/db07-0742

Metabolism

l-Carnosine, a Substrate of Carnosinase-1, Influences Glucose Metabolism

Sibylle Sauerhöfer; Gang Yuan; Gerald Stefan Braun; Martina Deinzer; Michael Neumaier; Norbert Gretz; Jürgen Floege; Wilhelm Kriz; Fokko van der Woude; Marcus Johannes Moeller

Abstracts

Topics: carnosine , mice , animals, transgenic , diabetic nephropathy

Diabetes October 2007, Vol.56, 2425-2432. doi:https://doi.org/10.2337/db07-0177

The Contribution of Splanchnic Fat to VLDL Triglyceride Is Greater in Insulin-Resistant Than Insulin-Sensitive Men and Women : Studies in the Postprandial State

Leanne Hodson; Alex S.T. Bickerton; Siobhán E. McQuaid; Rachel Roberts; Fredrik Karpe; Keith N. Frayn; Barbara A. Fielding

Abstracts

Topics: fatty acids , insulin , lipoproteins, vldl , postprandial period , nonesterified fatty acids

Diabetes October 2007, Vol.56, 2433-2441. doi:https://doi.org/10.2337/db07-0654

Glucagon, in Concert With Insulin, Supports the Postabsorptive Plasma Glucose Concentration in Humans

Suzanne M. Breckenridge; Benjamin A. Cooperberg; Ana Maria Arbelaez; Bruce W. Patterson; Philip E. Cryer

Abstracts

Topics: glucagon , glucose , insulin , octreotide , plasma glucose

Diabetes October 2007, Vol.56, 2442-2448. doi:https://doi.org/10.2337/db07-0751

PTEN Expression Contributes to the Regulation of Muscle Protein Degradation in Diabetes

Zhaoyong Hu; In Hee Lee; Xiaonan Wang; Hongmiao Sheng; Liping Zhang; Jie Du; William E. Mitch

Abstracts

Topics: muscle proteins , pten gene , 1-phosphatidylinositol 3-kinase , mice , catabolism

Diabetes October 2007, Vol.56, 2449-2456. doi:https://doi.org/10.2337/db06-1731

Mitochondrial Energetics in the Heart in Obesity-Related Diabetes: Direct Evidence for Increased Uncoupled Respiration and Activation of Uncoupling Proteins

Sihem Boudina; Sandra Sena; Heather Theobald; Xiaoming Sheng; Jordan J. Wright; Xia Xuan Hu; Salwa Aziz; Josie I. Johnson; Heiko Bugger; Vlad G. Zaha; E. Dale Abel

Abstracts

Topics: heart , mitochondria , fatty acids , glucose , mice

Diabetes October 2007, Vol.56, 2457-2466. doi:https://doi.org/10.2337/db07-0481

The Transcriptional Coactivator Peroxisome Proliferator–Activated Receptor (PPAR)γ Coactivator-1α and the Nuclear Receptor PPARα Control the Expression of Glycerol Kinase and Metabolism Genes Independently of PPARγ Activation in Human White Adipocytes

Anne Mazzucotelli; Nathalie Viguerie; Claire Tiraby; Jean-Sébastien Annicotte; Aline Mairal; Eva Klimcakova; Emmanuelle Lepin; Paul Delmar; Sébastien Dejean; Geneviève Tavernier; Corinne Lefort; Juan Hidalgo; Thierry Pineau; Lluis Fajas; Karine Clément; Dominique Langin

Abstracts

Topics: adipocytes , agonists , genes , ppar alpha , glycerol kinase

Diabetes October 2007, Vol.56, 2467-2475. doi:https://doi.org/10.2337/db06-1465

Phosphorylation Barriers to Skeletal and Cardiac Muscle Glucose Uptakes in High-Fat–Fed Mice: Studies in Mice With a 50% Reduction of Hexokinase II

Patrick T. Fueger; Robert S. Lee-Young; Jane Shearer; Deanna P. Bracy; Sami Heikkinen; Markku Laakso; Jeffrey N. Rottman; David H. Wasserman

Abstracts

Topics: glucose , insulin , mice , diet, high-fat , hexokinase

Diabetes October 2007, Vol.56, 2476-2484. doi:https://doi.org/10.2337/db07-0532

Farnesoid X Receptor Modulates Renal Lipid Metabolism, Fibrosis, and Diabetic Nephropathy

Tao Jiang; Xiaoxin X. Wang; Pnina Scherzer; Paul Wilson; James Tallman; Hideaki Takahashi; Jinping Li; Mieko Iwahashi; Eileen Sutherland; Lois Arend; Moshe Levi

Abstracts

Topics: agonists , cholic acid , diabetic nephropathy , fibrosis , kidney

Diabetes October 2007, Vol.56, 2485-2493. doi:https://doi.org/10.2337/db06-1642

Signal Transduction

Orexins Control Intestinal Glucose Transport by Distinct Neuronal, Endocrine, and Direct Epithelial Pathways

Robert Ducroc; Thierry Voisin; Aadil El Firar; Marc Laburthe

Abstracts

Topics: antagonists , glucose , glucose transport , intestines , oral glucose tolerance test

Diabetes October 2007, Vol.56, 2494-2500. doi:https://doi.org/10.2337/db07-0614

FGFR4 Prevents Hyperlipidemia and Insulin Resistance but Underlies High-Fat Diet–Induced Fatty Liver

Xinqiang Huang; Chaofeng Yang; Yongde Luo; Chengliu Jin; Fen Wang; Wallace L. McKeehan

Abstracts

Topics: cholesterol , diet , diet, high-fat , fatty liver , hepatocytes

Diabetes October 2007, Vol.56, 2501-2510. doi:https://doi.org/10.2337/db07-0648

Obesity Studies

Deficiency of Cbl-b Gene Enhances Infiltration and Activation of Macrophages in Adipose Tissue and Causes Peripheral Insulin Resistance in Mice

Katsuya Hirasaka; Shohei Kohno; Jumpei Goto; Harumi Furochi; Kazuaki Mawatari; Nagakatsu Harada; Toshio Hosaka; Yutaka Nakaya; Kazumi Ishidoh; Toshiyuki Obata; Yousuke Ebina; Hua Gu; Shin'ichi Takeda; Kyoichi Kishi; Takeshi Nikawa

Abstracts

Topics: insulin , insulin resistance , macrophages , mice , adipocytes

Diabetes October 2007, Vol.56, 2511-2522. doi:https://doi.org/10.2337/db06-1768

Cideb Regulates Diet-Induced Obesity, Liver Steatosis, and Insulin Sensitivity by Controlling Lipogenesis and Fatty Acid Oxidation

John Zhong Li; Jing Ye; Bofu Xue; Jingzhong Qi; Jing Zhang; Zhihong Zhou; Qing Li; Zilong Wen; Peng Li

Abstracts

Topics: diet , mice , obesity , fatty liver , liver

Diabetes October 2007, Vol.56, 2523-2532. doi:https://doi.org/10.2337/db07-0040

The Adipokine Lipocalin 2 Is Regulated by Obesity and Promotes Insulin Resistance

Qing-Wu Yan; Qin Yang; Nimesh Mody; Timothy E. Graham; Chung-Hsin Hsu; Zhao Xu; Nicholas E. Houstis; Barbara B. Kahn; Evan D. Rosen

Abstracts

Topics: adipocytes , insulin resistance , lipocalin-2 protein , mice , obesity

Diabetes October 2007, Vol.56, 2533-2540. doi:https://doi.org/10.2337/db07-0007

Mice Heterozygous for Tumor Necrosis Factor-α Converting Enzyme Are Protected From Obesity-Induced Insulin Resistance and Diabetes

Matteo Serino; Rossella Menghini; Loredana Fiorentino; Roberta Amoruso; Alessandro Mauriello; Davide Lauro; Paolo Sbraccia; Marta L. Hribal; Renato Lauro; Massimo Federici

Abstracts

Topics: insulin resistance , mice , obesity , transarterial chemoembolization , diet

Diabetes October 2007, Vol.56, 2541-2546. doi:https://doi.org/10.2337/db07-0360

Glucose Ingestion Fails to Inhibit Hypothalamic Neuronal Activity in Patients With Type 2 Diabetes

Solrun Vidarsdottir; Paul A.M. Smeets; Diane L. Eichelsheim; Matthias J.P. van Osch; Max A. Viergever; Johannes A. Romijn; Jeroen van der Grond; Hanno Pijl

Abstracts

Topics: blood oxygen level dependent , diabetes mellitus, type 2 , glucose , hypothalamus , ingestion

Diabetes October 2007, Vol.56, 2547-2550. doi:https://doi.org/10.2337/db07-0193

Immunology and Transplantation

In Vivo Cytotoxicity of Insulin-Specific CD8⁺ T-Cells in HLA-A*0201 Transgenic NOD Mice

Irene Jarchum; Jason C. Baker; Tatsuya Yamada; Toshiyuki Takaki; Michele P. Marron; David V. Serreze; Teresa P. DiLorenzo

Abstracts

Topics: cytotoxicity , hla-a2 antigen , insulin , mice , mice, inbred nod

Diabetes October 2007, Vol.56, 2551-2560. doi:https://doi.org/10.2337/db07-0332

Islet Studies

Essential Role for Signal Transducer and Activator of Transcription-1 in Pancreatic β-Cell Death and Autoimmune Type 1 Diabetes of Nonobese Diabetic Mice

Sunshin Kim; Hun Sik Kim; Kun Wook Chung; Seung Hoon Oh; Jong Won Yun; Sin-Hyeog Im; Moon-Kyu Lee; Kwang-Won Kim; Myung-Shik Lee

Abstracts

Topics: cytokine , diabetes mellitus, type 1 , endocrine pancreas , janus kinase , mice

Diabetes October 2007, Vol.56, 2561-2568. doi:https://doi.org/10.2337/db06-1372

β-Cell Mitochondria Exhibit Membrane Potential Heterogeneity That Can Be Altered by Stimulatory or Toxic Fuel Levels

Jakob D. Wikstrom; Shana M. Katzman; Hibo Mohamed; Gilad Twig; Solomon A. Graf; Emma Heart; Anthony J.A. Molina; Barbara E. Corkey; Lina Moitoso de Vargas; Nika N. Danial; Sheila Collins; Orian S. Shirihai

Abstracts

Topics: heterogeneity , mitochondria , glucose

Diabetes October 2007, Vol.56, 2569-2578. doi:https://doi.org/10.2337/db06-0757

Interaction Between Munc13-1 and RIM Is Critical for Glucagon-Like Peptide-1–Mediated Rescue of Exocytotic Defects in Munc13-1–Deficient Pancreatic β-Cells

Edwin P. Kwan; Li Xie; Laura Sheu; Toshihisa Ohtsuka; Herbert Y. Gaisano

Abstracts

Topics: cyclic amp , glucagon-like peptide 1 , insulin , radical retropubic prostatectomy , vesicle

Diabetes October 2007, Vol.56, 2579-2588. doi:https://doi.org/10.2337/db06-1207

Pathophysiology

Meal Fatty Acid Uptake in Visceral Fat in Women

Susanne B. Votruba; Rebecca S. Mattison; Daniel A. Dumesic; Christina Koutsari; Michael D. Jensen

Abstracts

Topics: fatty acids , visceral fat , adipose tissue , lipids

Diabetes October 2007, Vol.56, 2589-2597. doi:https://doi.org/10.2337/db07-0439

Complications

High-Fat Diet–Induced Neuropathy of Pre-Diabetes and Obesity : Effects of “Healthy” Diet and Aldose Reductase Inhibition

Irina G. Obrosova; Olga Ilnytska; Valeriy V. Lyzogubov; Ivan A. Pavlov; Nazar Mashtalir; Jerry L. Nadler; Viktor R. Drel

Abstracts

Topics: adenosine diphosphate ribose , aldehyde reductase , arachidonate 15-lipoxygenase , diet , diet, high-fat

Diabetes October 2007, Vol.56, 2598-2608. doi:https://doi.org/10.2337/db06-1176

Pharmacology and Therapeutics

The Peroxisome Proliferator–Activated Receptor-γ Agonist Pioglitazone Increases Number and Function of Endothelial Progenitor Cells in Patients With Coronary Artery Disease and Normal Glucose Tolerance

Christian Werner; Christel Hermann Kamani; Christoph Gensch; Michael Böhm; Ulrich Laufs

Abstracts

Topics: adiponectin , agonists , coronary arteriosclerosis , nadph oxidases , pioglitazone

Diabetes October 2007, Vol.56, 2609-2615. doi:https://doi.org/10.2337/db07-0069

Genetics

Association of the Vitamin D Metabolism Gene CYP27B1 With Type 1 Diabetes

Rebecca Bailey; Jason D. Cooper; Lauren Zeitels; Deborah J. Smyth; Jennie H.M. Yang; Neil M. Walker; Elina Hyppönen; David B. Dunger; Elizabeth Ramos-Lopez; Klaus Badenhoop; Sergey Nejentsev; John A. Todd

Abstracts

Topics: calcidiol 1-monooxygenase , diabetes mellitus, type 1 , genes , polymorphism , vitamin d3 24-hydroxylase

Diabetes October 2007, Vol.56, 2616-2621. doi:https://doi.org/10.2337/db07-0652

The Role of Melanocortin 3 Receptor Gene in Childhood Obesity

Yung Seng Lee; Larry Kok Seng Poh; Betty Lay Kee Kek; Kah Yin Loke

Abstracts

Topics: body fat , childhood obesity , genes , heterozygote , leptin

Diabetes October 2007, Vol.56, 2622-2630. doi:https://doi.org/10.2337/db07-0225

Association Study of the Genetic Polymorphisms of the Transcription Factor 7-Like 2 (TCF7L2) Gene and Type 2 Diabetes in the Chinese Population

Yi-Cheng Chang; Tien-Jyun Chang; Yi-Der Jiang; Shan-Shan Kuo; Kuan-Ching Lee; Ken C. Chiu; Lee-Ming Chuang

Abstracts

Topics: diabetes mellitus, type 2 , single nucleotide polymorphism , tcf7l2 gene , genes , polymorphism

Diabetes October 2007, Vol.56, 2631-2637. doi:https://doi.org/10.2337/db07-0421

Variants of the Transcription Factor 7-Like 2 (TCF7L2) Gene Are Associated With Type 2 Diabetes in an African-American Population Enriched for Nephropathy

Michèle M. Sale; Shelly G. Smith; Josyf C. Mychaleckyj; Keith L. Keene; Carl D. Langefeld; Tennille S. Leak; Pamela J. Hicks; Donald W. Bowden; Stephen S. Rich; Barry I. Freedman

Abstracts

Topics: diabetes mellitus, type 2 , genes , genotype determination , kidney diseases , single nucleotide polymorphism

Diabetes October 2007, Vol.56, 2638-2642. doi:https://doi.org/10.2337/db07-0012

A Genome-Wide Linkage Scan of Insulin Level–Derived Traits: The Amish Family Diabetes Study

Wen-Chi Hsueh; Kristi D. Silver; Toni I. Pollin; Callum J. Bell; Jeffrey R. O’Connell; Braxton D. Mitchell; Alan R. Shuldiner

Abstracts

Topics: fasting , genome , insulin , oral glucose tolerance test , insulin resistance

Diabetes October 2007, Vol.56, 2643-2648. doi:https://doi.org/10.2337/db06-1023

Errata

Extract

Topics: estradiol , leptin

Diabetes October 2007, Vol.56, 2649. doi:https://doi.org/10.2337/db07-er10

Errata

Extract

Topics: estradiol , ghrelin , rats , saline solutions , deuterium

Diabetes October 2007, Vol.56, 2649. doi:https://doi.org/10.2337/db07-er10a

ERRATA

Extract

Topics: alzheimer's disease , synaptophysin

Diabetes October 2007, Vol.56, 2650. doi:https://doi.org/10.2337/db07-er10b

ERRATA

Extract

Topics: atherosclerosis , estrogen , family studies , genes , insulin resistance

Diabetes October 2007, Vol.56, 2650. doi:https://doi.org/10.2337/db07-er10c

Online Letters to the Editor

Response to Comment on: Harmancey et al. (2007) Adrenomedullin Inhibits Adipogenesis Under Transcriptional Control of Insulin: Diabetes 56:553–563

Romain Harmancey; Fatima Smih

Extract

Topics: adrenomedullin , insulin , transcriptional control

Diabetes October 2007, Vol.56, e18. doi:https://doi.org/10.2337/db07-1003

Comment on: Buchanan (2007) (How) Can We Prevent Type 2 Diabetes? Diabetes 56:1502–1507

Lawrence S. Phillips

Extract