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Commentary
Testing the Gene or Testing a Variant? : The Case of TCF7L2
Diabetes October 2007, Vol.56, 2417-2419. doi:https://doi.org/10.2337/db07-0923
Perspectives in Diabetes
Estimation of β-Cell Mass by Metabolic Tests: Necessary, but How Sufficient?
Topics:
glucose
,
metabolic tests
,
insulin
Diabetes October 2007, Vol.56, 2420-2424. doi:https://doi.org/10.2337/db07-0742
Metabolism
l-Carnosine, a Substrate of Carnosinase-1, Influences Glucose Metabolism
Sibylle Sauerhöfer; Gang Yuan; Gerald Stefan Braun; Martina Deinzer; Michael Neumaier; Norbert Gretz; Jürgen Floege; Wilhelm Kriz; Fokko van der Woude; Marcus Johannes Moeller
Topics:
carnosine
,
mice
,
animals, transgenic
,
diabetic nephropathy
Diabetes October 2007, Vol.56, 2425-2432. doi:https://doi.org/10.2337/db07-0177
The Contribution of Splanchnic Fat to VLDL Triglyceride Is Greater in Insulin-Resistant Than Insulin-Sensitive Men and Women : Studies in the Postprandial State
Leanne Hodson; Alex S.T. Bickerton; Siobhán E. McQuaid; Rachel Roberts; Fredrik Karpe; Keith N. Frayn; Barbara A. Fielding
Topics:
fatty acids
,
insulin
,
lipoproteins, vldl
,
postprandial period
,
nonesterified fatty acids
Diabetes October 2007, Vol.56, 2433-2441. doi:https://doi.org/10.2337/db07-0654
Glucagon, in Concert With Insulin, Supports the Postabsorptive Plasma Glucose Concentration in Humans
Suzanne M. Breckenridge; Benjamin A. Cooperberg; Ana Maria Arbelaez; Bruce W. Patterson; Philip E. Cryer
Topics:
glucagon
,
glucose
,
insulin
,
octreotide
,
plasma glucose
Diabetes October 2007, Vol.56, 2442-2448. doi:https://doi.org/10.2337/db07-0751
PTEN Expression Contributes to the Regulation of Muscle Protein Degradation in Diabetes
Topics:
muscle proteins
,
pten gene
,
1-phosphatidylinositol 3-kinase
,
mice
,
catabolism
Diabetes October 2007, Vol.56, 2449-2456. doi:https://doi.org/10.2337/db06-1731
Mitochondrial Energetics in the Heart in Obesity-Related Diabetes: Direct Evidence for Increased Uncoupled Respiration and Activation of Uncoupling Proteins
Sihem Boudina; Sandra Sena; Heather Theobald; Xiaoming Sheng; Jordan J. Wright; Xia Xuan Hu; Salwa Aziz; Josie I. Johnson; Heiko Bugger; Vlad G. Zaha; E. Dale Abel
Topics:
heart
,
mitochondria
,
fatty acids
,
glucose
,
mice
Diabetes October 2007, Vol.56, 2457-2466. doi:https://doi.org/10.2337/db07-0481
The Transcriptional Coactivator Peroxisome Proliferator–Activated Receptor (PPAR)γ Coactivator-1α and the Nuclear Receptor PPARα Control the Expression of Glycerol Kinase and Metabolism Genes Independently of PPARγ Activation in Human White Adipocytes
Anne Mazzucotelli; Nathalie Viguerie; Claire Tiraby; Jean-Sébastien Annicotte; Aline Mairal; Eva Klimcakova; Emmanuelle Lepin; Paul Delmar; Sébastien Dejean; Geneviève Tavernier; Corinne Lefort; Juan Hidalgo; Thierry Pineau; Lluis Fajas; Karine Clément; Dominique Langin
Topics:
adipocytes
,
agonists
,
genes
,
ppar alpha
,
glycerol kinase
Diabetes October 2007, Vol.56, 2467-2475. doi:https://doi.org/10.2337/db06-1465
Phosphorylation Barriers to Skeletal and Cardiac Muscle Glucose Uptakes in High-Fat–Fed Mice: Studies in Mice With a 50% Reduction of Hexokinase II
Patrick T. Fueger; Robert S. Lee-Young; Jane Shearer; Deanna P. Bracy; Sami Heikkinen; Markku Laakso; Jeffrey N. Rottman; David H. Wasserman
Topics:
glucose
,
insulin
,
mice
,
diet, high-fat
,
hexokinase
Diabetes October 2007, Vol.56, 2476-2484. doi:https://doi.org/10.2337/db07-0532
Farnesoid X Receptor Modulates Renal Lipid Metabolism, Fibrosis, and Diabetic Nephropathy
Tao Jiang; Xiaoxin X. Wang; Pnina Scherzer; Paul Wilson; James Tallman; Hideaki Takahashi; Jinping Li; Mieko Iwahashi; Eileen Sutherland; Lois Arend; Moshe Levi
Topics:
agonists
,
cholic acid
,
diabetic nephropathy
,
fibrosis
,
kidney
Diabetes October 2007, Vol.56, 2485-2493. doi:https://doi.org/10.2337/db06-1642
Signal Transduction
Orexins Control Intestinal Glucose Transport by Distinct Neuronal, Endocrine, and Direct Epithelial Pathways
Topics:
antagonists
,
glucose
,
glucose transport
,
intestines
,
oral glucose tolerance test
Diabetes October 2007, Vol.56, 2494-2500. doi:https://doi.org/10.2337/db07-0614
FGFR4 Prevents Hyperlipidemia and Insulin Resistance but Underlies High-Fat Diet–Induced Fatty Liver
Topics:
cholesterol
,
diet
,
diet, high-fat
,
fatty liver
,
hepatocytes
Diabetes October 2007, Vol.56, 2501-2510. doi:https://doi.org/10.2337/db07-0648
Obesity Studies
Deficiency of Cbl-b Gene Enhances Infiltration and Activation of Macrophages in Adipose Tissue and Causes Peripheral Insulin Resistance in Mice
Katsuya Hirasaka; Shohei Kohno; Jumpei Goto; Harumi Furochi; Kazuaki Mawatari; Nagakatsu Harada; Toshio Hosaka; Yutaka Nakaya; Kazumi Ishidoh; Toshiyuki Obata; Yousuke Ebina; Hua Gu; Shin'ichi Takeda; Kyoichi Kishi; Takeshi Nikawa
Topics:
insulin
,
insulin resistance
,
macrophages
,
mice
,
adipocytes
Diabetes October 2007, Vol.56, 2511-2522. doi:https://doi.org/10.2337/db06-1768
Cideb Regulates Diet-Induced Obesity, Liver Steatosis, and Insulin Sensitivity by Controlling Lipogenesis and Fatty Acid Oxidation
John Zhong Li; Jing Ye; Bofu Xue; Jingzhong Qi; Jing Zhang; Zhihong Zhou; Qing Li; Zilong Wen; Peng Li
Topics:
diet
,
mice
,
obesity
,
fatty liver
,
liver
Diabetes October 2007, Vol.56, 2523-2532. doi:https://doi.org/10.2337/db07-0040
The Adipokine Lipocalin 2 Is Regulated by Obesity and Promotes Insulin Resistance
Qing-Wu Yan; Qin Yang; Nimesh Mody; Timothy E. Graham; Chung-Hsin Hsu; Zhao Xu; Nicholas E. Houstis; Barbara B. Kahn; Evan D. Rosen
Topics:
adipocytes
,
insulin resistance
,
lipocalin-2 protein
,
mice
,
obesity
Diabetes October 2007, Vol.56, 2533-2540. doi:https://doi.org/10.2337/db07-0007
Mice Heterozygous for Tumor Necrosis Factor-α Converting Enzyme Are Protected From Obesity-Induced Insulin Resistance and Diabetes
Matteo Serino; Rossella Menghini; Loredana Fiorentino; Roberta Amoruso; Alessandro Mauriello; Davide Lauro; Paolo Sbraccia; Marta L. Hribal; Renato Lauro; Massimo Federici
Topics:
insulin resistance
,
mice
,
obesity
,
transarterial chemoembolization
,
diet
Diabetes October 2007, Vol.56, 2541-2546. doi:https://doi.org/10.2337/db07-0360
Glucose Ingestion Fails to Inhibit Hypothalamic Neuronal Activity in Patients With Type 2 Diabetes
Solrun Vidarsdottir; Paul A.M. Smeets; Diane L. Eichelsheim; Matthias J.P. van Osch; Max A. Viergever; Johannes A. Romijn; Jeroen van der Grond; Hanno Pijl
Topics:
blood oxygen level dependent
,
diabetes mellitus, type 2
,
glucose
,
hypothalamus
,
ingestion
Diabetes October 2007, Vol.56, 2547-2550. doi:https://doi.org/10.2337/db07-0193
Immunology and Transplantation
In Vivo Cytotoxicity of Insulin-Specific CD8+ T-Cells in HLA-A*0201 Transgenic NOD Mice
Irene Jarchum; Jason C. Baker; Tatsuya Yamada; Toshiyuki Takaki; Michele P. Marron; David V. Serreze; Teresa P. DiLorenzo
Topics:
cytotoxicity
,
hla-a2 antigen
,
insulin
,
mice
,
mice, inbred nod
Diabetes October 2007, Vol.56, 2551-2560. doi:https://doi.org/10.2337/db07-0332
Islet Studies
Essential Role for Signal Transducer and Activator of Transcription-1 in Pancreatic β-Cell Death and Autoimmune Type 1 Diabetes of Nonobese Diabetic Mice
Sunshin Kim; Hun Sik Kim; Kun Wook Chung; Seung Hoon Oh; Jong Won Yun; Sin-Hyeog Im; Moon-Kyu Lee; Kwang-Won Kim; Myung-Shik Lee
Topics:
cytokine
,
diabetes mellitus, type 1
,
endocrine pancreas
,
janus kinase
,
mice
Diabetes October 2007, Vol.56, 2561-2568. doi:https://doi.org/10.2337/db06-1372
β-Cell Mitochondria Exhibit Membrane Potential Heterogeneity That Can Be Altered by Stimulatory or Toxic Fuel Levels
Jakob D. Wikstrom; Shana M. Katzman; Hibo Mohamed; Gilad Twig; Solomon A. Graf; Emma Heart; Anthony J.A. Molina; Barbara E. Corkey; Lina Moitoso de Vargas; Nika N. Danial; Sheila Collins; Orian S. Shirihai
Topics:
heterogeneity
,
mitochondria
,
glucose
Diabetes October 2007, Vol.56, 2569-2578. doi:https://doi.org/10.2337/db06-0757
Interaction Between Munc13-1 and RIM Is Critical for Glucagon-Like Peptide-1–Mediated Rescue of Exocytotic Defects in Munc13-1–Deficient Pancreatic β-Cells
Topics:
cyclic amp
,
glucagon-like peptide 1
,
insulin
,
radical retropubic prostatectomy
,
vesicle
Diabetes October 2007, Vol.56, 2579-2588. doi:https://doi.org/10.2337/db06-1207
Pathophysiology
Meal Fatty Acid Uptake in Visceral Fat in Women
Topics:
fatty acids
,
visceral fat
,
adipose tissue
,
lipids
Diabetes October 2007, Vol.56, 2589-2597. doi:https://doi.org/10.2337/db07-0439
Complications
High-Fat Diet–Induced Neuropathy of Pre-Diabetes and Obesity : Effects of “Healthy” Diet and Aldose Reductase Inhibition
Irina G. Obrosova; Olga Ilnytska; Valeriy V. Lyzogubov; Ivan A. Pavlov; Nazar Mashtalir; Jerry L. Nadler; Viktor R. Drel
Topics:
adenosine diphosphate ribose
,
aldehyde reductase
,
arachidonate 15-lipoxygenase
,
diet
,
diet, high-fat
Diabetes October 2007, Vol.56, 2598-2608. doi:https://doi.org/10.2337/db06-1176
Pharmacology and Therapeutics
The Peroxisome Proliferator–Activated Receptor-γ Agonist Pioglitazone Increases Number and Function of Endothelial Progenitor Cells in Patients With Coronary Artery Disease and Normal Glucose Tolerance
Topics:
adiponectin
,
agonists
,
coronary arteriosclerosis
,
nadph oxidases
,
pioglitazone
Diabetes October 2007, Vol.56, 2609-2615. doi:https://doi.org/10.2337/db07-0069
Genetics
Association of the Vitamin D Metabolism Gene CYP27B1 With Type 1 Diabetes
Rebecca Bailey; Jason D. Cooper; Lauren Zeitels; Deborah J. Smyth; Jennie H.M. Yang; Neil M. Walker; Elina Hyppönen; David B. Dunger; Elizabeth Ramos-Lopez; Klaus Badenhoop; Sergey Nejentsev; John A. Todd
Topics:
calcidiol 1-monooxygenase
,
diabetes mellitus, type 1
,
genes
,
polymorphism
,
vitamin d3 24-hydroxylase
Diabetes October 2007, Vol.56, 2616-2621. doi:https://doi.org/10.2337/db07-0652
The Role of Melanocortin 3 Receptor Gene in Childhood Obesity
Topics:
body fat
,
childhood obesity
,
genes
,
heterozygote
,
leptin
Diabetes October 2007, Vol.56, 2622-2630. doi:https://doi.org/10.2337/db07-0225
Association Study of the Genetic Polymorphisms of the Transcription Factor 7-Like 2 (TCF7L2) Gene and Type 2 Diabetes in the Chinese Population
Yi-Cheng Chang; Tien-Jyun Chang; Yi-Der Jiang; Shan-Shan Kuo; Kuan-Ching Lee; Ken C. Chiu; Lee-Ming Chuang
Topics:
diabetes mellitus, type 2
,
single nucleotide polymorphism
,
tcf7l2 gene
,
genes
,
polymorphism
Diabetes October 2007, Vol.56, 2631-2637. doi:https://doi.org/10.2337/db07-0421
Variants of the Transcription Factor 7-Like 2 (TCF7L2) Gene Are Associated With Type 2 Diabetes in an African-American Population Enriched for Nephropathy
Michèle M. Sale; Shelly G. Smith; Josyf C. Mychaleckyj; Keith L. Keene; Carl D. Langefeld; Tennille S. Leak; Pamela J. Hicks; Donald W. Bowden; Stephen S. Rich; Barry I. Freedman
Topics:
diabetes mellitus, type 2
,
genes
,
genotype determination
,
kidney diseases
,
single nucleotide polymorphism
Diabetes October 2007, Vol.56, 2638-2642. doi:https://doi.org/10.2337/db07-0012
A Genome-Wide Linkage Scan of Insulin Level–Derived Traits: The Amish Family Diabetes Study
Wen-Chi Hsueh; Kristi D. Silver; Toni I. Pollin; Callum J. Bell; Jeffrey R. O’Connell; Braxton D. Mitchell; Alan R. Shuldiner
Topics:
fasting
,
genome
,
insulin
,
oral glucose tolerance test
,
insulin resistance
Diabetes October 2007, Vol.56, 2643-2648. doi:https://doi.org/10.2337/db06-1023
Errata
Errata
Topics:
estradiol
,
ghrelin
,
rats
,
saline solutions
,
deuterium
Diabetes October 2007, Vol.56, 2649. doi:https://doi.org/10.2337/db07-er10a
ERRATA
Topics:
alzheimer's disease
,
synaptophysin
Diabetes October 2007, Vol.56, 2650. doi:https://doi.org/10.2337/db07-er10b
ERRATA
Topics:
atherosclerosis
,
estrogen
,
family studies
,
genes
,
insulin resistance
Diabetes October 2007, Vol.56, 2650. doi:https://doi.org/10.2337/db07-er10c
Online Letters to the Editor
Response to Comment on: Harmancey et al. (2007) Adrenomedullin Inhibits Adipogenesis Under Transcriptional Control of Insulin: Diabetes 56:553–563
Topics:
adrenomedullin
,
insulin
,
transcriptional control
Diabetes October 2007, Vol.56, e18. doi:https://doi.org/10.2337/db07-1003
Comment on: Buchanan (2007) (How) Can We Prevent Type 2 Diabetes? Diabetes 56:1502–1507
Topics:
diabetes mellitus, type 2
Diabetes October 2007, Vol.56, e19. doi:https://doi.org/10.2337/db07-0860