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Volume 56, Issue 11
November 2007
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ISSN 0012-1797
EISSN 1939-327X
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Editorial

Obesity: Mission Possible
James Levine
View articletitled, Obesity<span class="subtitle-colon">: </span><span class="subtitle">Mission Possible</span>
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Diabetes November 2007, Vol.56, 2653-2654. doi:https://doi.org/10.2337/db07-0951

Perspectives in Diabetes

Role of Low Energy Expenditure and Sitting in Obesity, Metabolic Syndrome, Type 2 Diabetes, and Cardiovascular Disease
Marc T. Hamilton; Deborah G. Hamilton; Theodore W. Zderic
View articletitled, Role of Low Energy Expenditure and Sitting in Obesity, Metabolic Syndrome, Type 2 Diabetes, and Cardiovascular Disease
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Diabetes November 2007, Vol.56, 2655-2667. doi:https://doi.org/10.2337/db07-0882
Economic Consequences of the Obese
C. Ford Runge
View articletitled, Economic Consequences of the Obese
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Diabetes November 2007, Vol.56, 2668-2672. doi:https://doi.org/10.2337/db07-0633
Evidence Implicating Eating as a Primary Driver for the Obesity Epidemic
Robert W. Jeffery; Lisa J. Harnack
View articletitled, Evidence Implicating Eating as a Primary Driver for the Obesity Epidemic
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Diabetes November 2007, Vol.56, 2673-2676. doi:https://doi.org/10.2337/db07-1029

New Methodologies and Databases

Noninvasive Magnetic Resonance Imaging of Microvascular Changes in Type 1 Diabetes
Zdravka Medarova; Gerardo Castillo; Guangping Dai; Elijah Bolotin; Alexei Bogdanov; Anna Moore
View articletitled, Noninvasive Magnetic Resonance Imaging of Microvascular Changes in Type 1 Diabetes
Supplementary data
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Diabetes November 2007, Vol.56, 2677-2682. doi:https://doi.org/10.2337/db07-0822

Metabolism

Effect of Insulin Deprivation on Muscle Mitochondrial ATP Production and Gene Transcript Levels in Type 1 Diabetic Subjects
Helen Karakelides; Yan W. Asmann; Maureen L. Bigelow; Kevin R. Short; Ketan Dhatariya; Jill Coenen-Schimke; Jane Kahl; Debabrata Mukhopadhyay; K. Sreekumaran Nair
View articletitled, Effect of Insulin Deprivation on Muscle Mitochondrial ATP Production and Gene Transcript Levels in Type 1 Diabetic Subjects
Supplementary data
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Diabetes November 2007, Vol.56, 2683-2689. doi:https://doi.org/10.2337/db07-0378
Endothelial Nitric Oxide Synthase (eNOS) Knockout Mice Have Defective Mitochondrial β-Oxidation
Eric Le Gouill; Maria Jimenez; Christophe Binnert; Pierre-Yves Jayet; Sebastien Thalmann; Pascal Nicod; Urs Scherrer; Peter Vollenweider
View articletitled, Endothelial Nitric Oxide Synthase (eNOS) Knockout Mice Have Defective Mitochondrial β-Oxidation
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Diabetes November 2007, Vol.56, 2690-2696. doi:https://doi.org/10.2337/db06-1228
Inflammation and Endothelial Activation Is Evident at Birth in Offspring of Mothers With Type 1 Diabetes
Scott M. Nelson; Naveed Sattar; Dilys J. Freeman; James D. Walker; Robert S. Lindsay
View articletitled, Inflammation and Endothelial Activation Is Evident at Birth in Offspring of Mothers With Type 1 Diabetes
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Diabetes November 2007, Vol.56, 2697-2704. doi:https://doi.org/10.2337/db07-0662
IGF-1 and Leptin Associate With Fetal HDL Cholesterol at Birth: Examination in Offspring of Mothers With Type 1 Diabetes
Scott M. Nelson; Dilys J. Freeman; Naveed Sattar; Frank D. Johnstone; Robert S. Lindsay
View articletitled, IGF-1 and Leptin Associate With Fetal HDL Cholesterol at Birth<span class="subtitle-colon">: </span><span class="subtitle">Examination in Offspring of Mothers With Type 1 Diabetes</span>
Supplementary data
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Diabetes November 2007, Vol.56, 2705-2709. doi:https://doi.org/10.2337/db07-0585
Low Birth Weight and Zygosity Status Is Associated With Defective Muscle Glycogen and Glycogen Synthase Regulation in Elderly Twins
Pernille Poulsen; Jørgen F.P. Wojtaszewski; Erik A. Richter; Henning Beck-Nielsen; Allan Vaag
View articletitled, Low Birth Weight and Zygosity Status Is Associated With Defective Muscle Glycogen and Glycogen Synthase Regulation in Elderly Twins
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Diabetes November 2007, Vol.56, 2710-2714. doi:https://doi.org/10.2337/db07-0155

Original Article

High Glucose Attenuates Protein S-Nitrosylation in Endothelial Cells: Role of Oxidative Stress
Carol Wadham; Angela Parker; Lijun Wang; Pu Xia
View articletitled, High Glucose Attenuates Protein <em>S</em>-Nitrosylation in Endothelial Cells<span class="subtitle-colon">: </span><span class="subtitle">Role of Oxidative Stress</span>
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Diabetes August 2007, Vol.56, 2715-2721. doi:https://doi.org/10.2337/db06-1294

Islet Studies

Evidence for a Role of Superoxide Generation in Glucose-Induced β-Cell Dysfunction In Vivo
Christine Tang; Ping Han; Andrei I. Oprescu; Simon C. Lee; Armen V. Gyulkhandanyan; Gary N.Y. Chan; Michael B. Wheeler; Adria Giacca
View articletitled, Evidence for a Role of Superoxide Generation in Glucose-Induced β-Cell Dysfunction In Vivo
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Diabetes November 2007, Vol.56, 2722-2731. doi:https://doi.org/10.2337/db07-0279
Protein Kinase C-ζ Activation Markedly Enhances β-Cell Proliferation: An Essential Role in Growth Factor–Mediated β-Cell Mitogenesis
Rupangi C. Vasavada; Lin Wang; Yuichi Fujinaka; Karen K. Takane; Taylor C. Rosa; Jose M.D. Mellado-Gil; Peter A. Friedman; Adolfo Garcia-Ocaña
View articletitled, Protein Kinase C-ζ Activation Markedly Enhances β-Cell Proliferation<span class="subtitle-colon">: </span><span class="subtitle">An Essential Role in Growth Factor–Mediated β-Cell Mitogenesis</span>
Supplementary data
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Diabetes November 2007, Vol.56, 2732-2743. doi:https://doi.org/10.2337/db07-0461
A Switch From Prohormone Convertase (PC)-2 to PC1/3 Expression in Transplanted α-Cells Is Accompanied by Differential Processing of Proglucagon and Improved Glucose Homeostasis in Mice
Rhonda D. Wideman; Scott D. Covey; Gene C. Webb; Daniel J. Drucker; Timothy J. Kieffer
View articletitled, A Switch From Prohormone Convertase (PC)-2 to PC1/3 Expression in Transplanted α-Cells Is Accompanied by Differential Processing of Proglucagon and Improved Glucose Homeostasis in Mice
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Diabetes November 2007, Vol.56, 2744-2752. doi:https://doi.org/10.2337/db07-0563

Pathophysiology

Evidence for Vasculoprotective Effects of ETB Receptors in Resistance Artery Remodeling in Diabetes
Kamakshi Sachidanandam; Vera Portik-Dobos; Alex K. Harris; Jim R. Hutchinson; Erin Muller; Maribeth H. Johnson; Adviye Ergul
View articletitled, Evidence for Vasculoprotective Effects of ET<sub>B</sub> Receptors in Resistance Artery Remodeling in Diabetes
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Diabetes November 2007, Vol.56, 2753-2758. doi:https://doi.org/10.2337/db07-0426
Genes Involved in Fatty Acid Partitioning and Binding, Lipolysis, Monocyte/Macrophage Recruitment, and Inflammation Are Overexpressed in the Human Fatty Liver of Insulin-Resistant Subjects
Jukka Westerbacka; Maria Kolak; Tuula Kiviluoto; Perttu Arkkila; Jukka Sirén; Anders Hamsten; Rachel M. Fisher; Hannele Yki-Järvinen
View articletitled, Genes Involved in Fatty Acid Partitioning and Binding, Lipolysis, Monocyte/Macrophage Recruitment, and Inflammation Are Overexpressed in the Human Fatty Liver of Insulin-Resistant Subjects
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Diabetes November 2007, Vol.56, 2759-2765. doi:https://doi.org/10.2337/db07-0156

Complications

Attenuation of Amydgala and Frontal Cortical Responses to Low Blood Glucose Concentration in Asymptomatic Hypoglycemia in Type 1 Diabetes: A New Player in Hypoglycemia Unawareness?
Joel T. Dunn; Iain Cranston; Paul K. Marsden; Stephanie A. Amiel; Laurence J. Reed
View articletitled, Attenuation of Amydgala and Frontal Cortical Responses to Low Blood Glucose Concentration in Asymptomatic Hypoglycemia in Type 1 Diabetes<span class="subtitle-colon">: </span><span class="subtitle">A New Player in Hypoglycemia Unawareness?</span>
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Diabetes November 2007, Vol.56, 2766-2773. doi:https://doi.org/10.2337/db07-0666
Serum Cystatin C Predicts Progression of Subclinical Coronary Atherosclerosis in Individuals With Type 1 Diabetes
David M. Maahs; Lorraine G. Ogden; Adam Kretowski; Janet K. Snell-Bergeon; Gregory L. Kinney; Tomas Berl; Marian Rewers
View articletitled, Serum Cystatin C Predicts Progression of Subclinical Coronary Atherosclerosis in Individuals With Type 1 Diabetes
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Diabetes November 2007, Vol.56, 2774-2779. doi:https://doi.org/10.2337/db07-0539
Decreased l-Type Ca2+ Current in Cardiac Myocytes of Type 1 Diabetic Akita Mice Due to Reduced Phosphatidylinositol 3-Kinase Signaling
Zhongju Lu; Ya-Ping Jiang; Xin-Hua Xu; Lisa M. Ballou; Ira S. Cohen; Richard Z. Lin
View articletitled, Decreased <span class="small-caps">l-</span>Type Ca<sup>2+</sup> Current in Cardiac Myocytes of Type 1 Diabetic Akita Mice Due to Reduced Phosphatidylinositol 3-Kinase Signaling
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Diabetes November 2007, Vol.56, 2780-2789. doi:https://doi.org/10.2337/db06-1629
Evidence of Increased Inflammation and Microcirculatory Abnormalities in Patients With Type 1 Diabetes and Their Role in Microvascular Complications
Sridevi Devaraj; Anthony T. Cheung; Ishwarlal Jialal; Steven C. Griffen; Danh Nguyen; Nicole Glaser; Thomas Aoki
View articletitled, Evidence of Increased Inflammation and Microcirculatory Abnormalities in Patients With Type 1 Diabetes and Their Role in Microvascular Complications
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Diabetes November 2007, Vol.56, 2790-2796. doi:https://doi.org/10.2337/db07-0784

Pharmacology and Therapeutics

S 26948: a New Specific Peroxisome Proliferator–Activated Receptor γ Modulator With Potent Antidiabetes and Antiatherogenic Effects
Maria Carmen Carmona; Katie Louche; Bruno Lefebvre; Antoine Pilon; Nathalie Hennuyer; Véronique Audinot-Bouchez; Catherine Fievet; Gérard Torpier; Pierre Formstecher; Pierre Renard; Philippe Lefebvre; Catherine Dacquet; Bart Staels; Louis Casteilla; Luc Pénicaud; on behalf of the Consortium of the French Ministry of Research and Technology
View articletitled, S 26948<span class="subtitle-colon">: </span><span class="subtitle">a New Specific Peroxisome Proliferator–Activated Receptor γ Modulator With Potent Antidiabetes and Antiatherogenic Effects</span>
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Diabetes November 2007, Vol.56, 2797-2808. doi:https://doi.org/10.2337/db06-1734
Abnormal Connexin Expression Underlies Delayed Wound Healing in Diabetic Skin
Chiuhui Mary Wang; Jill Lincoln; Jeremy E. Cook; David L. Becker
View articletitled, Abnormal Connexin Expression Underlies Delayed Wound Healing in Diabetic Skin
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Diabetes November 2007, Vol.56, 2809-2817. doi:https://doi.org/10.2337/db07-0613

Genetics

Genotype by Diabetes Interaction Effects on the Detection of Linkage of Glomerular Filtration Rate to a Region on Chromosome 2q in Mexican Americans
Sobha Puppala; Rector Arya; Farook Thameem; Nedal H. Arar; Kusum Bhandari; Donna M. Lehman; Jennifer Schneider; Sharon Fowler; Vidya S. Farook; Vincent P. Diego; Laura Almasy; John Blangero; Michael P. Stern; Ravindranath Duggirala; Hanna E. Abboud
View articletitled, Genotype by Diabetes Interaction Effects on the Detection of Linkage of Glomerular Filtration Rate to a Region on Chromosome 2q in Mexican Americans
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Diabetes November 2007, Vol.56, 2818-2828. doi:https://doi.org/10.2337/db06-0984
Impact of Kir6.2 E23K Polymorphism on the Development of Type 2 Diabetes in a General Japanese Population : The Hisayama Study
Yasufumi Doi; Michiaki Kubo; Toshiharu Ninomiya; Koji Yonemoto; Masanori Iwase; Hisatomi Arima; Jun Hata; Yumihiro Tanizaki; Mitsuo Iida; Yutaka Kiyohara
View articletitled, Impact of Kir6.2 E23K Polymorphism on the Development of Type 2 Diabetes in a General Japanese Population <span class="subtitle-colon">: </span><span class="subtitle">The Hisayama Study</span>
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Diabetes November 2007, Vol.56, 2829-2833. doi:https://doi.org/10.2337/db07-1709
Frequency of the G/G Genotype of Resistin Single Nucleotide Polymorphism at −420 Appears to Be Increased in Younger-Onset Type 2 Diabetes
Masaaki Ochi; Haruhiko Osawa; Yushi Hirota; Kazuo Hara; Yasuharu Tabara; Yoshiharu Tokuyama; Ikki Shimizu; Azuma Kanatsuka; Yasuhisa Fujii; Jun Ohashi; Tetsuro Miki; Naoto Nakamura; Takashi Kadowaki; Mitsuo Itakura; Masato Kasuga; Hideichi Makino
View articletitled, Frequency of the G/G Genotype of Resistin Single Nucleotide Polymorphism at −420 Appears to Be Increased in Younger-Onset Type 2 Diabetes
Supplementary data
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Diabetes November 2007, Vol.56, 2834-2838. doi:https://doi.org/10.2337/db06-1157
Système International (SI) Units Table
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus
Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes: Many Differences, Few Similarities
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