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Issues
Obesity Studies
IGF-Binding Protein-2 Protects Against the Development of Obesity and Insulin Resistance
Stephen B. Wheatcroft; Mark T. Kearney; Ajay M. Shah; Vivienne A. Ezzat; John R. Miell; Michael Modo; Stephen C.R. Williams; Will P. Cawthorn; Gema Medina-Gomez; Antonio Vidal-Puig; Jaswinder K. Sethi; Paul A. Crossey
Diabetes February 2007, Vol.56, 285-294. doi:https://doi.org/10.2337/db06-0436
Wnt10b Inhibits Obesity in ob/ob and Agouti Mice
Wendy S. Wright; Kenneth A. Longo; Vernon W. Dolinsky; Isabelle Gerin; Sona Kang; Christina N. Bennett; Shian-Huey Chiang; Tyler C. Prestwich; Catherine Gress; Charles F. Burant; Vedrana S. Susulic; Ormond A. MacDougald
Diabetes February 2007, Vol.56, 295-303. doi:https://doi.org/10.2337/db06-1339
Islet Studies
Identification of the Amyloid-Degrading Enzyme Neprilysin in Mouse Islets and Potential Role in Islet Amyloidogenesis
Sakeneh Zraika; Rebecca L. Hull; Jayalakshmi Udayasankar; Anne Clark; Kristina M. Utzschneider; Jenny Tong; Fernando Gerchman; Steven E. Kahn
Diabetes February 2007, Vol.56, 304-310. doi:https://doi.org/10.2337/db06-0430
Melanin Concentrating Hormone Is a Novel Regulator of Islet Function and Growth
Pavlos Pissios; Umut Ozcan; Efi Kokkotou; Terumasa Okada; Chong Wee Liew; Siming Liu; Jennifer N. Peters; Gabriella Dahlgren; Jason Karamchandani; Yogish C. Kudva; Amarnath J. Kurpad; Robert T. Kennedy; Eleftheria Maratos-Flier; Rohit N. Kulkarni
Diabetes February 2007, Vol.56, 311-319. doi:https://doi.org/10.2337/db06-0708
Glucose-Dependent Regulation of γ-Aminobutyric Acid (GABAA) Receptor Expression in Mouse Pancreatic Islet α-Cells
Diabetes February 2007, Vol.56, 320-327. doi:https://doi.org/10.2337/db06-0712
An ATP-Binding Mutation (G334D) in KCNJ11 Is Associated With a Sulfonylurea-Insensitive Form of Developmental Delay, Epilepsy, and Neonatal Diabetes
Ricard Masia; Joseph C. Koster; Stefano Tumini; Francesco Chiarelli; Carlo Colombo; Colin G. Nichols; Fabrizio Barbetti
Diabetes February 2007, Vol.56, 328-336. doi:https://doi.org/10.2337/db06-1275
Glucotoxicity in the INS-1 Rat Insulinoma Cell Line Is Mediated by the Orphan Nuclear Receptor Small Heterodimer Partner
Keun-Gyu Park; Kyeong-Min Lee; Hye-Young Seo; Ji-Ho Suh; Hye-Soon Kim; Li Wang; Kyu-Chang Won; Hyoung-Woo Lee; Joong-Yeol Park; Ki-Up Lee; Jung-Guk Kim; Bo-Wan Kim; Hueng-Sik Choi; In-Kyu Lee
Diabetes February 2007, Vol.56, 431-437. doi:https://doi.org/10.2337/db06-0753
Sulfonylurea Compounds Uncouple the Glucose Dependence of the Insulinotropic Effect of Glucagon-Like Peptide 1
Diabetes February 2007, Vol.56, 438-443. doi:https://doi.org/10.2337/db06-0738
Complications
Salicylate-Based Anti-Inflammatory Drugs Inhibit the Early Lesion of Diabetic Retinopathy
Diabetes February 2007, Vol.56, 337-345. doi:https://doi.org/10.2337/db06-0789
Deletion of Protein Kinase C-β Isoform In Vivo Reduces Renal Hypertrophy but Not Albuminuria in the Streptozotocin-Induced Diabetic Mouse Model
Matthias Meier; Joon-Keun Park; Daniel Overheu; Torsten Kirsch; Carsten Lindschau; Faikah Gueler; Michael Leitges; Jan Menne; Hermann Haller
Diabetes February 2007, Vol.56, 346-354. doi:https://doi.org/10.2337/db06-0891
Treatment of Streptozotocin-Induced Diabetic Rats With AVE7688, a Vasopeptidase Inhibitor: Effect on Vascular and Neural Disease
Diabetes February 2007, Vol.56, 355-362. doi:https://doi.org/10.2337/db06-1180
Macrophage Scavenger Receptor-A–Deficient Mice Are Resistant Against Diabetic Nephropathy Through Amelioration of Microinflammation
Hitomi Kataoka Usui; Kenichi Shikata; Motofumi Sasaki; Shinichi Okada; Mitsuhiro Matsuda; Yasushi Shikata; Daisuke Ogawa; Yuichi Kido; Ryo Nagase; Kosuke Yozai; Sakiko Ohga; Atsuhito Tone; Jun Wada; Motohiro Takeya; Seikoh Horiuchi; Tatsuhiko Kodama; Hirofumi Makino
Diabetes February 2007, Vol.56, 363-372. doi:https://doi.org/10.2337/db06-0359
Topical Administration of Nepafenac Inhibits Diabetes-Induced Retinal Microvascular Disease and Underlying Abnormalities of Retinal Metabolism and Physiology
Timothy S. Kern; Casey M. Miller; Yunpeng Du; Ling Zheng; Susanne Mohr; Sherry L. Ball; M. Kim; Jeffrey A. Jamison; David P. Bingaman
Diabetes February 2007, Vol.56, 373-379. doi:https://doi.org/10.2337/db05-1621
Impact of Type 2 Diabetes on Nitric Oxide and Adrenergic Modulation of Myocardial Perfusion
Mette M. Madsen; Hanne M. Søndergaard; Morten Bøttcher; Niels H. Buus; Ole Schmitz; Hans E. Bøtker; Torsten T. Nielsen
Diabetes February 2007, Vol.56, 468-475. doi:https://doi.org/10.2337/db06-0635
High Glucose, High Insulin, and Their Combination Rapidly Induce Laminin-β1 Synthesis by Regulation of mRNA Translation in Renal Epithelial Cells
Meenalakshmi M. Mariappan; Denis Feliers; Srinivas Mummidi; Goutam Ghosh Choudhury; Balakuntalam S. Kasinath
Diabetes February 2007, Vol.56, 476-485. doi:https://doi.org/10.2337/db05-1334
Brief Reports
Haplotypes of Transcription Factor 7–Like 2 (TCF7L2) Gene and Its Upstream Region Are Associated With Type 2 Diabetes and Age of Onset in Mexican Americans
Donna M. Lehman; Kelly J. Hunt; Robin J. Leach; Jeanette Hamlington; Rector Arya; Hanna E. Abboud; Ravindranath Duggirala; John Blangero; Harald H.H. Göring; Michael P. Stern
Diabetes February 2007, Vol.56, 389-393. doi:https://doi.org/10.2337/db06-0860
P2 Promoter Variants of the Hepatocyte Nuclear Factor 4α Gene Are Associated With Type 2 Diabetes in Mexican Americans
Donna M. Lehman; Dawn K. Richardson; Chris P. Jenkinson; Kelly J. Hunt; Thomas D. Dyer; Robin J. Leach; Rector Arya; Hanna E. Abboud; John Blangero; Ravindranath Duggirala; Michael P. Stern
Diabetes February 2007, Vol.56, 513-517. doi:https://doi.org/10.2337/db06-0881
Women With Mitochondrial Haplogroup N9a Are Protected Against Metabolic Syndrome
Masashi Tanaka; Noriyuki Fuku; Yutaka Nishigaki; Hitoshi Matsuo; Tomonori Segawa; Sachiro Watanabe; Kimihiko Kato; Kiyoshi Yoko; Masafumi Ito; Yoshinori Nozawa; Yoshiji Yamada
Diabetes February 2007, Vol.56, 518-521. doi:https://doi.org/10.2337/db06-1105
PTPN22 R620W Functional Variant in Type 1 Diabetes and Autoimmunity Related Traits
Claude Chelala; Sabine Duchatelet; Marie-Line Joffret; Regine Bergholdt; Danièle Dubois-Laforgue; Pegah Ghandil; Flemming Pociot; Sophie Caillat-Zucman; José Timsit; Cécile Julier
Diabetes February 2007, Vol.56, 522-526. doi:https://doi.org/10.2337/db06-0942
Myocardial Uptake of Circulating Triglycerides in Nondiabetic Patients With Heart Disease
Diabetes February 2007, Vol.56, 527-530. doi:https://doi.org/10.2337/db06-1552
Type 2 Diabetes–Associated Missense Polymorphisms KCNJ11 E23K and ABCC8 A1369S Influence Progression to Diabetes and Response to Interventions in the Diabetes Prevention Program
Jose C. Florez; Kathleen A. Jablonski; Steven E. Kahn; Paul W. Franks; Dana Dabelea; Richard F. Hamman; William C. Knowler; David M. Nathan; David Altshuler; for the Diabetes Prevention Program Research Groupy
Diabetes February 2007, Vol.56, 531-536. doi:https://doi.org/10.2337/db06-0966
Linkage and Association Analyses of Type 2 Diabetes/Impaired Glucose Metabolism and Adiponectin Serum Levels in Japanese Americans From Hawaii
Ilija P. Kovac; Richard J. Havlik; Daniel Foley; Rita Peila; Dena Hernandez; Fabienne Wavrant-De Vrièze; Andrew Singleton; Josephine Egan; Dennis Taub; Beatriz Rodriguez; Kamal Masaki; J. David Curb; Wilfred Y. Fujimoto; Alexander F. Wilson
Diabetes February 2007, Vol.56, 537-540. doi:https://doi.org/10.2337/db06-0443
Signal Transduction
Ceramide- and Oxidant-Induced Insulin Resistance Involve Loss of Insulin-Dependent Rac-Activation and Actin Remodeling in Muscle Cells
Diabetes February 2007, Vol.56, 394-403. doi:https://doi.org/10.2337/db06-0823
Protein–Tyrosine Phosphatase 1B–Deficient Myocytes Show Increased Insulin Sensitivity and Protection Against Tumor Necrosis Factor-α–Induced Insulin Resistance
Iria Nieto-Vazquez; Sonia Fernández-Veledo; Cristina de Alvaro; Cristina M. Rondinone; Angela M. Valverde; Margarita Lorenzo
Diabetes February 2007, Vol.56, 404-413. doi:https://doi.org/10.2337/db06-0989
The Rab GTPase-Activating Protein AS160 Integrates Akt, Protein Kinase C, and AMP-Activated Protein Kinase Signals Regulating GLUT4 Traffic
Diabetes February 2007, Vol.56, 414-423. doi:https://doi.org/10.2337/db06-0900
Immunology and Transplantation
Cellular Expression Requirements for Inhibition of Type 1 Diabetes by a Dominantly Protective Major Histocompatibility Complex Haplotype
Diabetes February 2007, Vol.56, 424-430. doi:https://doi.org/10.2337/db06-1303
Pathophysiology
Pancreatic Lipomatosis Is a Structural Marker in Nondiabetic Children With Mutations in Carboxyl-Ester Lipase
Helge Ræder; Ingfrid S. Haldorsen; Lars Ersland; Renate Grüner; Torfinn Taxt; Oddmund Søvik; Anders Molven; Pål R. Njølstad
Diabetes February 2007, Vol.56, 444-449. doi:https://doi.org/10.2337/db06-0859
Pharmacology and Therapeutics
Oral Insulin-Mimetic Compounds That Act Independently of Insulin
Silvia García-Vicente; Francesc Yraola; Luc Marti; Elena González-Muñoz; María José García-Barrado; Carles Cantó; Anna Abella; Sandy Bour; Rafael Artuch; Cristina Sierra; Nuria Brandi; Christian Carpéné; Julio Moratinos; Marta Camps; Manuel Palacín; Xavier Testar; Anna Gumà; Fernando Albericio; Miriam Royo; Alec Mian; Antonio Zorzano
Diabetes February 2007, Vol.56, 486-493. doi:https://doi.org/10.2337/db06-0269
Genetics
A Possible Role for the PPARG Pro12Ala Polymorphism in Preterm Birth
Aline Meirhaeghe; Colin A.G. Boreham; Liam J. Murray; Florence Richard; George Davey Smith; Ian S. Young; Philippe Amouyel
Diabetes February 2007, Vol.56, 494-498. doi:https://doi.org/10.2337/db06-0915
Tag Polymorphisms at the A20 (TNFAIP3) Locus Are Associated With Lower Gene Expression and Increased Risk of Coronary Artery Disease in Type 2 Diabetes
Watip Boonyasrisawat; Delphine Eberle; Simonetta Bacci; Yuan-Yuan Zhang; David Nolan; Ernest V. Gervino; Michael T. Johnstone; Vincenzo Trischitta; Steven E. Shoelson; Alessandro Doria
Diabetes February 2007, Vol.56, 499-505. doi:https://doi.org/10.2337/db06-0946
Genetic Reconstitution of Autoimmune Type 1 Diabetes With Two Major Susceptibility Genes in the Rat
Diabetes February 2007, Vol.56, 506-512. doi:https://doi.org/10.2337/db06-1027
Perspectives in Diabetes
Diabetes and Suppressors of Cytokine Signaling Proteins
Diabetes February 2007, Vol.56, 541-548. doi:https://doi.org/10.2337/db06-1068