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Issues
Obesity Studies
Adrenomedullin Inhibits Adipogenesis Under Transcriptional Control of Insulin
Diabetes March 2007, Vol.56, 553-563. doi:https://doi.org/10.2337/db06-0857
Diet-Induced Increases in Adiposity, but Not Plasma Lipids, Promote Macrophage Infiltration Into White Adipose Tissue
Diabetes March 2007, Vol.56, 564-573. doi:https://doi.org/10.2337/db06-1375
Antidiabetic Effects of cis-9, trans-11–Conjugated Linoleic Acid May Be Mediated via Anti-Inflammatory Effects in White Adipose Tissue
Fiona Moloney; Sinead Toomey; Enda Noone; Anne Nugent; Bernard Allan; Christine E. Loscher; Helen M. Roche
Diabetes March 2007, Vol.56, 574-582. doi:https://doi.org/10.2337/db06-0384
Opposing Effects of Adiponectin Receptors 1 and 2 on Energy Metabolism
Mikael Bjursell; Andrea Ahnmark; Mohammad Bohlooly-Y; Lena William-Olsson; Magdalena Rhedin; Xiao-Rong Peng; Karolina Ploj; Anna-Karin Gerdin; Gunnel Arnerup; Anders Elmgren; Anna-Lena Berg; Jan Oscarsson; Daniel Lindén
Diabetes March 2007, Vol.56, 583-593. doi:https://doi.org/10.2337/db06-1432
Immunology/Transplantation
Superiority of Small Islets in Human Islet Transplantation
Roger Lehmann; Richard A. Zuellig; Patrick Kugelmeier; Philipp B. Baenninger; Wolfgang Moritz; Aurel Perren; Pierre-Alain Clavien; Markus Weber; Giatgen A. Spinas
Diabetes March 2007, Vol.56, 594-603. doi:https://doi.org/10.2337/db06-0779
No Alterations in the Frequency of FOXP3+ Regulatory T-Cells in Type 1 Diabetes
Todd Brusko; Clive Wasserfall; Kieran McGrail; Richard Schatz; Hilla Lee Viener; Desmond Schatz; Michael Haller; Jennifer Rockell; Peter Gottlieb; Michael Clare-Salzler; Mark Atkinson
Diabetes March 2007, Vol.56, 604-612. doi:https://doi.org/10.2337/db06-1248
CD8+ T-Cell Responses Identify β-Cell Autoimmunity in Human Type 1 Diabetes
Roberto Mallone; Emanuela Martinuzzi; Philippe Blancou; Giulia Novelli; Georgia Afonso; Manuel Dolz; Graziella Bruno; Lucy Chaillous; Lucienne Chatenoud; Jean-Marie Bach; Peter van Endert
Diabetes March 2007, Vol.56, 613-621. doi:https://doi.org/10.2337/db06-1419
CCL4 Protects From Type 1 Diabetes by Altering Islet β-Cell–Targeted Inflammatory Responses
Craig Meagher; Guillermo Arreaza; Andrew Peters; Craig A. Strathdee; Philippe A. Gilbert; Qing-Sheng Mi; Pere Santamaria; Gregory A. Dekaban; Terry L. Delovitch
Diabetes March 2007, Vol.56, 809-817. doi:https://doi.org/10.2337/db06-0619
Islet Studies
PED/PEA-15 Regulates Glucose-Induced Insulin Secretion by Restraining Potassium Channel Expression in Pancreatic β-Cells
Claudia Miele; Gregory Alexander Raciti; Angela Cassese; Chiara Romano; Ferdinando Giacco; Francesco Oriente; Flora Paturzo; Francesco Andreozzi; Assunta Zabatta; Giancarlo Troncone; Fatima Bosch; Anna Pujol; Hervé Chneiweiss; Pietro Formisano; Francesco Beguinot
Diabetes March 2007, Vol.56, 622-633. doi:https://doi.org/10.2337/db06-1260
Rapid Turnover of Phosphatidylinositol-4,5-Bisphosphate in Insulin-Secreting Cells Mediated by Ca2+ and the ATP-to-ADP Ratio
Diabetes March 2007, Vol.56, 818-826. doi:https://doi.org/10.2337/db06-0843
Complications
Contributions of Inflammation and Cardiac Matrix Metalloproteinase Activity to Cardiac Failure in Diabetic Cardiomyopathy: The Role of Angiotensin Type 1 Receptor Antagonism
Dirk Westermann; Susanne Rutschow; Sebastian Jäger; Anne Linderer; Stefan Anker; Alexander Riad; Thomas Unger; Heinz-Peter Schultheiss; Matthias Pauschinger; Carsten Tschöpe
Diabetes March 2007, Vol.56, 641-646. doi:https://doi.org/10.2337/db06-1163
Anti-Inflammatory Effects of the Advanced Glycation End Product Inhibitor LR-90 in Human Monocytes
Diabetes March 2007, Vol.56, 647-655. doi:https://doi.org/10.2337/db06-0936
Endothelial Nitric Oxide Synthase Uncoupling Impairs Endothelial Progenitor Cell Mobilization and Function in Diabetes
Thomas Thum; Daniela Fraccarollo; Maximilian Schultheiss; Sabrina Froese; Paolo Galuppo; Julian D. Widder; Dimitrios Tsikas; Georg Ertl; Johann Bauersachs
Diabetes March 2007, Vol.56, 666-674. doi:https://doi.org/10.2337/db06-0699
Relationship of Traditional and Nontraditional Cardiovascular Risk Factors to Coronary Artery Calcium in Type 2 Diabetes
Theodore Mazzone; Peter M. Meyer; George T. Kondos; Michael H. Davidson; Steven B. Feinstein; Ralph B. D’Agostino, Sr.; Alfonso Perez; Steven M. Haffner
Diabetes March 2007, Vol.56, 849-855. doi:https://doi.org/10.2337/db06-0935
Genetics
Investigation of the Estrogen Receptor-α Gene With Type 2 Diabetes and/or Nephropathy in African-American and European-American Populations
Carla J. Gallagher; Keith L. Keene; Josyf C. Mychaleckyj; Carl D. Langefeld; Joel N. Hirschhorn; Brian E. Henderson; Candace J. Gordon; Barry I. Freedman; Stephen S. Rich; Donald W. Bowden; Michèle M. Sale
Diabetes March 2007, Vol.56, 675-684. doi:https://doi.org/10.2337/db06-0303
Evaluation of Common Variants in the Six Known Maturity-Onset Diabetes of the Young (MODY) Genes for Association With Type 2 Diabetes
Wendy Winckler; Michael N. Weedon; Robert R. Graham; Steven A. McCarroll; Shaun Purcell; Peter Almgren; Tiinamaija Tuomi; Daniel Gaudet; Kristina Bengtsson Boström; Mark Walker; Graham Hitman; Andrew T. Hattersley; Mark I. McCarthy; Kristin G. Ardlie; Joel N. Hirschhorn; Mark J. Daly; Timothy M. Frayling; Leif Groop; David Altshuler
Diabetes March 2007, Vol.56, 685-693. doi:https://doi.org/10.2337/db06-0202
Activating Transcription Factor 6 (ATF6) Sequence Polymorphisms in Type 2 Diabetes and Pre-Diabetic Traits
Winston S. Chu; Swapan Kumar Das; Hua Wang; Juliana C. Chan; Panos Deloukas; Philippe Froguel; Leslie J. Baier; Weiping Jia; Mark I. McCarthy; Maggie C.Y. Ng; Coleen Damcott; Alan R. Shuldiner; Eleftheria Zeggini; Steven C. Elbein
Diabetes March 2007, Vol.56, 856-862. doi:https://doi.org/10.2337/db06-1305
Polymorphisms of the Renin-Angiotensin System Genes Predict Progression of Subclinical Coronary Atherosclerosis
Adam Kretowski; Kim McFann; John E. Hokanson; David Maahs; Gregory Kinney; Janet K. Snell-Bergeon; R. Paul Wadwa; Robert H. Eckel; Lorraine Ogden; Satish Garg; Jia Li; Suzanne Cheng; Henry A. Erlich; Marian Rewers
Diabetes March 2007, Vol.56, 863-871. doi:https://doi.org/10.2337/db06-1321
Genetic Variation, C-Reactive Protein Levels, and Incidence of Diabetes
Abbas Dehghan; Isabella Kardys; Moniek P.M. de Maat; Andre G. Uitterlinden; Eric J.G. Sijbrands; Aart H. Bootsma; Theo Stijnen; Albert Hofman; Miranda T. Schram; Jacqueline C.M. Witteman
Diabetes March 2007, Vol.56, 872-878. doi:https://doi.org/10.2337/db06-0922
Brief Reports
Common Variation in LMNA Increases Susceptibility to Type 2 Diabetes and Associates With Elevated Fasting Glycemia and Estimates of Body Fat and Height in the General Population: Studies of 7,495 Danish Whites
Lise Wegner; Gitte Andersen; Thomas Sparsø; Niels Grarup; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Diabetes March 2007, Vol.56, 694-698. doi:https://doi.org/10.2337/db06-0927
No Evidence for Mouse Pancreatic β-Cell Epithelial-Mesenchymal Transition In Vitro
Diabetes March 2007, Vol.56, 699-702. doi:https://doi.org/10.2337/db06-1446
Limited Capacity of Human Adult Islets Expanded In Vitro to Redifferentiate Into Insulin-Producing β-Cells
Ayse G. Kayali; Luis E. Flores; Ana D. Lopez; Burak Kutlu; Emmanuel Baetge; Ryuichi Kitamura; Ergeng Hao; Gillian M. Beattie; Alberto Hayek
Diabetes March 2007, Vol.56, 703-708. doi:https://doi.org/10.2337/db06-1545
Evaluation of Polymorphic Splicing in the Mechanism of the Association of the Insulin Gene With Diabetes
Diabetes March 2007, Vol.56, 709-713. doi:https://doi.org/10.2337/db06-0402
Analysis of Genetic Variation in Akt2/PKB-β in Severe Insulin Resistance, Lipodystrophy, Type 2 Diabetes, and Related Metabolic Phenotypes
Karen Tan; Wendy A. Kimber; Jian’an Luan; Maria A. Soos; Robert K. Semple; Nicholas J. Wareham; Stephen O’Rahilly; Inês Barroso
Diabetes March 2007, Vol.56, 714-719. doi:https://doi.org/10.2337/db06-0921
Common Variation in the LMNA Gene (Encoding Lamin A/C) and Type 2 Diabetes: Association Analyses in 9,518 Subjects
Katharine R. Owen; Christopher J. Groves; Robert L. Hanson; William C. Knowler; Alan R. Shuldiner; Steven C. Elbein; Braxton D. Mitchell; Philippe Froguel; Maggie C.Y. Ng; Juliana C. Chan; Weiping Jia; Panos Deloukas; Graham A. Hitman; Mark Walker; Timothy M. Frayling; Andrew T. Hattersley; Eleftheria Zeggini; Mark I. McCarthy; for the International Type 2 Diabetes 1q Consortium
Diabetes March 2007, Vol.56, 879-883. doi:https://doi.org/10.2337/db06-0930
Lamin A/C Polymorphisms, Type 2 Diabetes, and the Metabolic Syndrome: Case-Control and Quantitative Trait Studies
José L. Mesa; Ruth J.F. Loos; Paul W. Franks; Ken K. Ong; Jian’an Luan; Stephen O’Rahilly; Nicholas J. Wareham; Inês Barroso
Diabetes March 2007, Vol.56, 884-889. doi:https://doi.org/10.2337/db06-1055
Meta-Analysis of Genome-Wide Linkage Studies of Quantitative Lipid Traits in Families Ascertained for Type 2 Diabetes
Alka Malhotra; Steven C. Elbein; Maggie C.Y. Ng; Ravindranath Duggirala; Rector Arya; Giuseppina Imperatore; Adebowale Adeyemo; Toni I. Pollin; Wen-Chi Hsueh; Juliana C.N. Chan; Charles Rotimi; Robert L. Hanson; Sandra J. Hasstedt; Johanna K. Wolford; and the American Diabetes Association GENNID Study Group
Diabetes March 2007, Vol.56, 890-896. doi:https://doi.org/10.2337/db06-1057
Metabolism
Family History of Diabetes Links Impaired Substrate Switching and Reduced Mitochondrial Content in Skeletal Muscle
Barbara Ukropcova; Olga Sereda; Lilian de Jonge; Iwona Bogacka; Tuong Nguyen; Hui Xie; George A. Bray; Steven R. Smith
Diabetes March 2007, Vol.56, 720-727. doi:https://doi.org/10.2337/db06-0521
Endothelin Limits Insulin Action in Obese/Insulin-Resistant Humans
Diabetes March 2007, Vol.56, 728-734. doi:https://doi.org/10.2337/db06-1406
Increases in Adiponectin Predict Improved Liver, but Not Peripheral, Insulin Sensitivity in Severely Obese Women During Weight Loss
Edward Lin; Lawrence S. Phillips; Thomas R. Ziegler; Brian Schmotzer; Kongjun Wu; Li H. Gu; Leena Khaitan; Scott A. Lynch; William E. Torres; C. Daniel Smith; Nana Gletsu-Miller
Diabetes March 2007, Vol.56, 735-742. doi:https://doi.org/10.2337/db06-1161
Paradoxical Changes in Muscle Gene Expression in Insulin-Resistant Subjects After Sustained Reduction in Plasma Free Fatty Acid Concentration
Mandeep Bajaj; Rafael Medina-Navarro; Swangjit Suraamornkul; Christian Meyer; Ralph A. DeFronzo; Lawrence J. Mandarino
Diabetes March 2007, Vol.56, 743-752. doi:https://doi.org/10.2337/db06-0840
Two Years of Treatment With Dehydroepiandrosterone Does Not Improve Insulin Secretion, Insulin Action, or Postprandial Glucose Turnover in Elderly Men or Women
Rita Basu; Chiara Dalla Man; Marco Campioni; Ananda Basu; K. Sree Nair; Michael D. Jensen; Sundeep Khosla; George Klee; Gianna Toffolo; Claudio Cobelli; Robert A. Rizza
Diabetes March 2007, Vol.56, 753-766. doi:https://doi.org/10.2337/db06-1504
The Small Polyphenolic Molecule Kaempferol Increases Cellular Energy Expenditure and Thyroid Hormone Activation
Wagner S. da-Silva; John W. Harney; Brian W. Kim; Jing Li; Suzy D.C. Bianco; Alessandra Crescenzi; Marcelo A. Christoffolete; Stephen A. Huang; Antonio C. Bianco
Diabetes March 2007, Vol.56, 767-776. doi:https://doi.org/10.2337/db06-1488
Role of Excess Glycogenolysis in Fasting Hyperglycemia Among Pre-Diabetic and Diabetic Zucker (fa/fa) Rats
Diabetes March 2007, Vol.56, 777-785. doi:https://doi.org/10.2337/db06-0717
Signal Transduction
AMP-Activated Protein Kinase α2 Deficiency Affects Cardiac Cardiolipin Homeostasis and Mitochondrial Function
Yoni Athéa; Benoît Viollet; Philippe Mateo; Delphine Rousseau; Marta Novotova; Anne Garnier; Sophie Vaulont; James R. Wilding; Alain Grynberg; Vladimir Veksler; Jacqueline Hoerter; Renée Ventura-Clapier
Diabetes March 2007, Vol.56, 786-794. doi:https://doi.org/10.2337/db06-0187
Effects of Pioglitazone on Suppressor of Cytokine Signaling 3 Expression: Potential Mechanisms for Its Effects on Insulin Sensitivity and Adiponectin Expression
Yukiko Kanatani; Isao Usui; Ken Ishizuka; Agussalim Bukhari; Shiho Fujisaka; Masaharu Urakaze; Tetsuro Haruta; Tadamitsu Kishimoto; Tetsuji Naka; Masashi Kobayashi
Diabetes March 2007, Vol.56, 795-803. doi:https://doi.org/10.2337/db06-1039
Globular Adiponectin Activates Nuclear Factor-κB and Activating Protein-1 and Enhances Angiotensin II–Induced Proliferation in Cardiac Fibroblasts
Yoshiyuki Hattori; Sachiko Hattori; Kazumi Akimoto; Toshio Nishikimi; Kunihiro Suzuki; Hiroaki Matsuoka; Kikuo Kasai
Diabetes March 2007, Vol.56, 804-808. doi:https://doi.org/10.2337/db06-1405
Pathophysiology
Effect of Acute Exercise on AMPK Signaling in Skeletal Muscle of Subjects With Type 2 Diabetes: A Time-Course and Dose-Response Study
Apiradee Sriwijitkamol; Dawn K. Coletta; Estela Wajcberg; Gabriela B. Balbontin; Sara M. Reyna; John Barrientes; Phyllis A. Eagan; Christopher P. Jenkinson; Eugenio Cersosimo; Ralph A. DeFronzo; Kei Sakamoto; Nicolas Musi
Diabetes March 2007, Vol.56, 836-848. doi:https://doi.org/10.2337/db06-1119
