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Volume 56, Issue 6
June 2007
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ISSN 0012-1797
EISSN 1939-327X
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Banting Lecture 2006

Orchestration of Glucose Homeostasis: From a Small Acorn to the California Oak
Richard N. Bergman
View articletitled, Orchestration of Glucose Homeostasis<span class="subtitle-colon">: </span><span class="subtitle">From a Small Acorn to the California Oak</span>
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Diabetes June 2007, Vol.56, 1489-1501. doi:https://doi.org/10.2337/db07-9903

Perspectives in Diabetes

(How) Can We Prevent Type 2 Diabetes?
Thomas A. Buchanan
View articletitled, (How) Can We Prevent Type 2 Diabetes?
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Diabetes June 2007, Vol.56, 1502-1507. doi:https://doi.org/10.2337/db07-0140

Signal Transduction

Global Assessment of Regulation of Phosphorylation of Insulin Receptor Substrate-1 by Insulin In Vivo in Human Muscle
Zhengping Yi; Paul Langlais; Elena A. De Filippis; Moulun Luo; Charles R. Flynn; Stefanie Schroeder; Susan T. Weintraub; Rebekka Mapes; Lawrence J. Mandarino
View articletitled, Global Assessment of Regulation of Phosphorylation of Insulin Receptor Substrate-1 by Insulin In Vivo in Human Muscle
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Diabetes June 2007, Vol.56, 1508-1516. doi:https://doi.org/10.2337/db06-1355
The STAT5A-Mediated Induction of Pyruvate Dehydrogenase Kinase 4 Expression by Prolactin or Growth Hormone in Adipocytes
Ursula A. White; Ann A. Coulter; Tiffany K. Miles; Jacqueline M. Stephens
View articletitled, The STAT5A-Mediated Induction of Pyruvate Dehydrogenase Kinase 4 Expression by Prolactin or Growth Hormone in Adipocytes
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Diabetes June 2007, Vol.56, 1623-1629. doi:https://doi.org/10.2337/db06-1286
Interleukin-6 Directly Increases Glucose Metabolism in Resting Human Skeletal Muscle
Stephan Glund; Atul Deshmukh; Yun Chau Long; Theodore Moller; Heikki A. Koistinen; Kenneth Caidahl; Juleen R. Zierath; Anna Krook
View articletitled, Interleukin-6 Directly Increases Glucose Metabolism in Resting Human Skeletal Muscle
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Diabetes June 2007, Vol.56, 1630-1637. doi:https://doi.org/10.2337/db06-1733
Growth Hormone Regulation of p85α Expression and Phosphoinositide 3-Kinase Activity in Adipose Tissue: Mechanism for Growth Hormone–Mediated Insulin Resistance
Juan-Pablo del Rincon; Keiji Iida; Bruce D. Gaylinn; Carrie E. McCurdy; J. Wayne Leitner; Linda A. Barbour; John J. Kopchick; Jacob E. Friedman; Boris Draznin; Michael O. Thorner
View articletitled, Growth Hormone Regulation of p85α Expression and Phosphoinositide 3-Kinase Activity in Adipose Tissue<span class="subtitle-colon">: </span><span class="subtitle">Mechanism for Growth Hormone–Mediated Insulin Resistance</span>
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Diabetes June 2007, Vol.56, 1638-1646. doi:https://doi.org/10.2337/db06-0299

Obesity Studies

Adipogenesis in Obesity Requires Close Interplay Between Differentiating Adipocytes, Stromal Cells, and Blood Vessels
Satoshi Nishimura; Ichiro Manabe; Mika Nagasaki; Yumiko Hosoya; Hiroshi Yamashita; Hideo Fujita; Mitsuru Ohsugi; Kazuyuki Tobe; Takashi Kadowaki; Ryozo Nagai; Seiryo Sugiura
View articletitled, Adipogenesis in Obesity Requires Close Interplay Between Differentiating Adipocytes, Stromal Cells, and Blood Vessels
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Diabetes June 2007, Vol.56, 1517-1526. doi:https://doi.org/10.2337/db06-1749
Increasing Dietary Leucine Intake Reduces Diet-Induced Obesity and Improves Glucose and Cholesterol Metabolism in Mice via Multimechanisms
Yiying Zhang; Kaiying Guo; Robert E. LeBlanc; Daniella Loh; Gary J. Schwartz; Yi-Hao Yu
View articletitled, Increasing Dietary Leucine Intake Reduces Diet-Induced Obesity and Improves Glucose and Cholesterol Metabolism in Mice via Multimechanisms
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Diabetes June 2007, Vol.56, 1647-1654. doi:https://doi.org/10.2337/db07-0123
Omentin Plasma Levels and Gene Expression Are Decreased in Obesity
Celia M. de Souza Batista; Rong-Ze Yang; Mi-Jeong Lee; Nicole M. Glynn; Dao-Zhan Yu; Jessica Pray; Kelechi Ndubuizu; Susheel Patil; Alan Schwartz; Mark Kligman; Susan K. Fried; Da-Wei Gong; Alan R. Shuldiner; Toni I. Pollin; John C. McLenithan
View articletitled, Omentin Plasma Levels and Gene Expression Are Decreased in Obesity
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Diabetes June 2007, Vol.56, 1655-1661. doi:https://doi.org/10.2337/db06-1506
PPARα Agonists Suppress Osteopontin Expression in Macrophages and Decrease Plasma Levels in Patients With Type 2 Diabetes
Takafumi Nakamachi; Takashi Nomiyama; Florence Gizard; Elizabeth B. Heywood; Karrie L. Jones; Yue Zhao; Lucia Fuentes; Kohzo Takebayashi; Yoshimasa Aso; Bart Staels; Toshihiko Inukai; Dennis Bruemmer
View articletitled, PPARα Agonists Suppress Osteopontin Expression in Macrophages and Decrease Plasma Levels in Patients With Type 2 Diabetes
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Diabetes June 2007, Vol.56, 1662-1670. doi:https://doi.org/10.2337/db06-1177
Glucagon-Like Peptide-1 Gene Therapy in Obese Diabetic Mice Results in Long-Term Cure of Diabetes by Improving Insulin Sensitivity and Reducing Hepatic Gluconeogenesis
Young-Sun Lee; Seungjin Shin; Toshikatsu Shigihara; Eunsil Hahm; Meng-Ju Liu; Jaeseok Han; Ji-Won Yoon; Hee-Sook Jun
View articletitled, Glucagon-Like Peptide-1 Gene Therapy in Obese Diabetic Mice Results in Long-Term Cure of Diabetes by Improving Insulin Sensitivity and Reducing Hepatic Gluconeogenesis
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Diabetes June 2007, Vol.56, 1671-1679. doi:https://doi.org/10.2337/db06-1182
Body Size and Shape Changes and the Risk of Diabetes in the Diabetes Prevention Program
Wilfred Y. Fujimoto; Kathleen A. Jablonski; George A. Bray; Andrea Kriska; Elizabeth Barrett-Connor; Steven Haffner; Robert Hanson; James O. Hill; Van Hubbard; E. Stamm; F. Xavier Pi-Sunyer; for the Diabetes Prevention Program Research Group
View articletitled, Body Size and Shape Changes and the Risk of Diabetes in the Diabetes Prevention Program
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Diabetes June 2007, Vol.56, 1680-1685. doi:https://doi.org/10.2337/db07-0009

Immunology and Transplantation

GAD Autoantibody Affinity and Epitope Specificity Identify Distinct Immunization Profiles in Children at Risk for Type 1 Diabetes
Anja Mayr; Michael Schlosser; Natalie Grober; Heidrun Kenk; Anette G. Ziegler; Ezio Bonifacio; Peter Achenbach
View articletitled, GAD Autoantibody Affinity and Epitope Specificity Identify Distinct Immunization Profiles in Children at Risk for Type 1 Diabetes
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Diabetes June 2007, Vol.56, 1527-1533. doi:https://doi.org/10.2337/db06-1715
Transient Upregulation of Indoleamine 2,3-Dioxygenase in Dendritic Cells by Human Chorionic Gonadotropin Downregulates Autoimmune Diabetes
Aito Ueno; Suzanne Cho; Lu Cheng; Jianxiong Wang; Sheng Hou; Hiroko Nakano; Pere Santamaria; Yang Yang
View articletitled, Transient Upregulation of Indoleamine 2,3-Dioxygenase in Dendritic Cells by Human Chorionic Gonadotropin Downregulates Autoimmune Diabetes
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Diabetes June 2007, Vol.56, 1686-1693. doi:https://doi.org/10.2337/db06-1727

Islet Studies

Chronic Activation of Liver X Receptor Induces β-Cell Apoptosis Through Hyperactivation of Lipogenesis: Liver X Receptor–Mediated Lipotoxicity in Pancreatic β-Cells
Sung Sik Choe; A Hyun Choi; Joo-Won Lee; Kang Ho Kim; Jun-Jae Chung; Jiyoung Park; Kyeong-Min Lee; Keun-Gyu Park; In-Kyu Lee; Jae Bum Kim
View articletitled, Chronic Activation of Liver X Receptor Induces β-Cell Apoptosis Through Hyperactivation of Lipogenesis<span class="subtitle-colon">: </span><span class="subtitle">Liver X Receptor–Mediated Lipotoxicity in Pancreatic β-Cells</span>
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Diabetes June 2007, Vol.56, 1534-1543. doi:https://doi.org/10.2337/db06-1059
Implantation Site–Dependent Dysfunction of Transplanted Pancreatic Islets
Joey Lau; Göran Mattsson; Carina Carlsson; Daniel Nyqvist; Martin Köhler; Per-Olof Berggren; Leif Jansson; Per-Ola Carlsson
View articletitled, Implantation Site–Dependent Dysfunction of Transplanted Pancreatic Islets
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Diabetes June 2007, Vol.56, 1544-1550. doi:https://doi.org/10.2337/db06-1258
Glucose-Dependent Modulation of Insulin Secretion and Intracellular Calcium Ions by GKA50, a Glucokinase Activator
Daniel Johnson; Ruth M. Shepherd; Debra Gill; Tracy Gorman; David M. Smith; Mark J. Dunne
View articletitled, Glucose-Dependent Modulation of Insulin Secretion and Intracellular Calcium Ions by GKA50, a Glucokinase Activator
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Diabetes June 2007, Vol.56, 1694-1702. doi:https://doi.org/10.2337/db07-0026
Contribution of Hepatic and Extrahepatic Insulin Resistance to the Pathogenesis of Impaired Fasting Glucose: Role of Increased Rates of Gluconeogenesis
Gerlies Bock; Elizabeth Chittilapilly; Rita Basu; Gianna Toffolo; Claudio Cobelli; Visvanathan Chandramouli; Bernard R. Landau; Robert A. Rizza
View articletitled, Contribution of Hepatic and Extrahepatic Insulin Resistance to the Pathogenesis of Impaired Fasting Glucose<span class="subtitle-colon">: </span><span class="subtitle">Role of Increased Rates of Gluconeogenesis</span>
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Diabetes June 2007, Vol.56, 1703-1711. doi:https://doi.org/10.2337/db06-1776

Pathophysiology

Downregulation of GLP-1 and GIP Receptor Expression by Hyperglycemia: Possible Contribution to Impaired Incretin Effects in Diabetes
Gang Xu; Hideaki Kaneto; D. Ross Laybutt; Valerie F. Duvivier-Kali; Nitin Trivedi; Kiyoshi Suzuma; George L. King; Gordon C. Weir; Susan Bonner-Weir
View articletitled, Downregulation of GLP-1 and GIP Receptor Expression by Hyperglycemia<span class="subtitle-colon">: </span><span class="subtitle">Possible Contribution to Impaired Incretin Effects in Diabetes</span>
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Diabetes June 2007, Vol.56, 1551-1558. doi:https://doi.org/10.2337/db06-1033
Paradoxical Elevation of High–Molecular Weight Adiponectin in Acquired Extreme Insulin Resistance Due to Insulin Receptor Antibodies
Robert K. Semple; Nils H. Halberg; Keith Burling; Maria A. Soos; Todd Schraw; Jian'an Luan; Elaine K. Cochran; David B. Dunger; Nicholas J. Wareham; Philipp E. Scherer; Phillip Gorden; Stephen O'Rahilly
View articletitled, Paradoxical Elevation of High–Molecular Weight Adiponectin in Acquired Extreme Insulin Resistance Due to Insulin Receptor Antibodies
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Diabetes June 2007, Vol.56, 1712-1717. doi:https://doi.org/10.2337/db06-1665

Complications

High Glucose Impairs Early and Late Endothelial Progenitor Cells by Modifying Nitric Oxide–Related but Not Oxidative Stress–Mediated Mechanisms
Yung-Hsiang Chen; Shing-Jong Lin; Feng-Yen Lin; Tao-Cheng Wu; Chen-Rong Tsao; Po-Hsun Huang; Po-Len Liu; Yuh-Lien Chen; Jaw-Wen Chen
View articletitled, High Glucose Impairs Early and Late Endothelial Progenitor Cells by Modifying Nitric Oxide–Related but Not Oxidative Stress–Mediated Mechanisms
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Diabetes June 2007, Vol.56, 1559-1568. doi:https://doi.org/10.2337/db06-1103
Pathogenesis of Spinally Mediated Hyperalgesia in Diabetes
Khara M. Ramos; Yun Jiang; Camilla I. Svensson; Nigel A. Calcutt
View articletitled, Pathogenesis of Spinally Mediated Hyperalgesia in Diabetes
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Diabetes June 2007, Vol.56, 1569-1576. doi:https://doi.org/10.2337/db06-1269
Genome-Wide Scans for Diabetic Nephropathy and Albuminuria in Multiethnic Populations: The Family Investigation of Nephropathy and Diabetes (FIND)
Sudha K. Iyengar; Hanna E. Abboud; Katrina A.B. Goddard; Mohammed F. Saad; Sharon G. Adler; Nedal H. Arar; Donald W. Bowden; Ravi Duggirala; Robert C. Elston; Robert L. Hanson; Eli Ipp; W.H. Linda Kao; Paul L. Kimmel; Michael J. Klag; William C. Knowler; Lucy A. Meoni; Robert G. Nelson; Susanne B. Nicholas; Madeleine V. Pahl; Rulan S. Parekh; Shannon R.E. Quade; Stephen S. Rich; Jerome I. Rotter; Marina Scavini; Jeffrey R. Schelling; John R. Sedor; Ashwini R. Sehgal; Vallabh O. Shah; Michael W. Smith; Kent D. Taylor; Cheryl A. Winkler; Philip G. Zager; Barry I. Freedman; on behalf of the Family Investigation of Nephropathy and Diabetes Research Group
View articletitled, Genome-Wide Scans for Diabetic Nephropathy and Albuminuria in Multiethnic Populations<span class="subtitle-colon">: </span><span class="subtitle">The Family Investigation of Nephropathy and Diabetes (FIND)</span>
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Diabetes June 2007, Vol.56, 1577-1585. doi:https://doi.org/10.2337/db06-1154
Variations in Adiponectin Receptor Genes and Susceptibility to Type 2 Diabetes in Women: A Tagging–Single Nucleotide Polymorphism Haplotype Analysis
Lu Qi; Alessandro Doria; Elena Giorgi; Frank B. Hu
View articletitled, Variations in Adiponectin Receptor Genes and Susceptibility to Type 2 Diabetes in Women<span class="subtitle-colon">: </span><span class="subtitle">A Tagging–Single Nucleotide Polymorphism Haplotype Analysis</span>
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Diabetes June 2007, Vol.56, 1586-1591. doi:https://doi.org/10.2337/db06-1447
Prevalence and Prognostic Impact of Subclinical Cardiovascular Disease in Individuals With the Metabolic Syndrome and Diabetes
Erik Ingelsson; Lisa M. Sullivan; Joanne M. Murabito; Caroline S. Fox; Emelia J. Benjamin; Joseph F. Polak; James B. Meigs; Michelle J. Keyes; Christopher J. O'Donnell; Thomas J. Wang; Ralph B. D'Agostino, Sr.; Philip A. Wolf; Ramachandran S. Vasan
View articletitled, Prevalence and Prognostic Impact of Subclinical Cardiovascular Disease in Individuals With the Metabolic Syndrome and Diabetes
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Diabetes June 2007, Vol.56, 1718-1726. doi:https://doi.org/10.2337/db07-0078

Metabolism

Mitochondrial Respiration Is Decreased in Skeletal Muscle of Patients With Type 2 Diabetes
Martin Mogensen; Kent Sahlin; Maria Fernström; Dorte Glintborg; Birgitte F. Vind; Henning Beck-Nielsen; Kurt Højlund
View articletitled, Mitochondrial Respiration Is Decreased in Skeletal Muscle of Patients With Type 2 Diabetes
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Diabetes June 2007, Vol.56, 1592-1599. doi:https://doi.org/10.2337/db06-0981
The Mammalian Target of Rapamycin Pathway Regulates Nutrient-Sensitive Glucose Uptake in Man
Michael Krebs; Barbara Brunmair; Attila Brehm; Michaela Artwohl; Julia Szendroedi; Peter Nowotny; Erich Roth; Clemens Fürnsinn; Miriam Promintzer; Christian Anderwald; Martin Bischof; Michael Roden
View articletitled, The Mammalian Target of Rapamycin Pathway Regulates Nutrient-Sensitive Glucose Uptake in Man
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Diabetes June 2007, Vol.56, 1600-1607. doi:https://doi.org/10.2337/db06-1016
Resistance Exercise and Insulin Regulate AS160 and Interaction With 14-3-3 in Human Skeletal Muscle
Kirsten F. Howlett; Kei Sakamoto; Andrew Garnham; David Cameron-Smith; Mark Hargreaves
View articletitled, Resistance Exercise and Insulin Regulate AS160 and Interaction With 14-3-3 in Human Skeletal Muscle
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Diabetes June 2007, Vol.56, 1608-1614. doi:https://doi.org/10.2337/db06-1398
Aerobic Exercise Overcomes the Age-Related Insulin Resistance of Muscle Protein Metabolism by Improving Endothelial Function and Akt/Mammalian Target of Rapamycin Signaling
Satoshi Fujita; Blake B. Rasmussen; Jerson G. Cadenas; Micah J. Drummond; Erin L. Glynn; Fred R. Sattler; Elena Volpi
View articletitled, Aerobic Exercise Overcomes the Age-Related Insulin Resistance of Muscle Protein Metabolism by Improving Endothelial Function and Akt/Mammalian Target of Rapamycin Signaling
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Diabetes June 2007, Vol.56, 1615-1622. doi:https://doi.org/10.2337/db06-1566

Brief Reports

Reduction in Microalbuminuria as an Integrated Indicator for Renal and Cardiovascular Risk Reduction in Patients With Type 2 Diabetes
Shin-ichi Araki; Masakazu Haneda; Daisuke Koya; Hideki Hidaka; Toshiro Sugimoto; Motohide Isono; Keiji Isshiki; Masami Chin-Kanasaki; Takashi Uzu; Atsunori Kashiwagi
View articletitled, Reduction in Microalbuminuria as an Integrated Indicator for Renal and Cardiovascular Risk Reduction in Patients With Type 2 Diabetes
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Diabetes June 2007, Vol.56, 1727-1730. doi:https://doi.org/10.2337/db06-1646
A Novel Susceptibility Locus on Rat Chromosome 8 Affects Spontaneous but Not Experimentally Induced Type 1 Diabetes
Robert H. Wallis; KeSheng Wang; Dominika Dabrowski; Leili Marandi; Terri Ning; Eugene Hsieh; Andrew D. Paterson; John P. Mordes; Elisabeth P. Blankenhorn; Philippe Poussier
View articletitled, A Novel Susceptibility Locus on Rat Chromosome 8 Affects Spontaneous but Not Experimentally Induced Type 1 Diabetes
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Diabetes June 2007, Vol.56, 1731-1736. doi:https://doi.org/10.2337/db06-1790
New ABCC8 Mutations in Relapsing Neonatal Diabetes and Clinical Features
Martine Vaxillaire; Aurélie Dechaume; Kanetee Busiah; Hélène Cavé; Sabrina Pereira; Raphael Scharfmann; Guiomar Perez de Nanclares; Luis Castano; Philippe Froguel; Michel Polak; and the SUR1–Neonatal Diabetes Study Group
View articletitled, New <em>ABCC8</em> Mutations in Relapsing Neonatal Diabetes and Clinical Features
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Diabetes June 2007, Vol.56, 1737-1741. doi:https://doi.org/10.2337/db06-1540
Quantitative Trait Loci for Fasting Glucose in Young Europeans Replicate Previous Findings for Type 2 Diabetes in 2q23–24 and Other Locations
Delphine Fradin; Simon Heath; Mark Lathrop; Pierre Bougnères
View articletitled, Quantitative Trait Loci for Fasting Glucose in Young Europeans Replicate Previous Findings for Type 2 Diabetes in 2q23–24 and Other Locations
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Diabetes June 2007, Vol.56, 1742-1745. doi:https://doi.org/10.2337/db06-1329

Erratum

Errata
View articletitled, Errata
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Diabetes June 2007, Vol.56, 1746. doi:https://doi.org/10.2337/db07-er06
Errata
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Diabetes June 2007, Vol.56, 1747. doi:https://doi.org/10.2337/db07-er06a
Système International (SI) Units Table
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus
Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes: Many Differences, Few Similarities
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