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Metabolism

Neuregulins Increase Mitochondrial Oxidative Capacity and Insulin Sensitivity in Skeletal Muscle Cells

Carles Cantó; Sara Pich; José C. Paz; Rosario Sanches; Vicente Martínez; Meritxell Orpinell; Manuel Palacín; Antonio Zorzano; Anna Gumà

Abstracts

View articletitled, Neuregulins Increase Mitochondrial Oxidative Capacity and Insulin Sensitivity in Skeletal Muscle Cells

Supplementary data

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Topics: neuregulins , mitochondria

Diabetes September 2007, Vol.56, 2185-2193. doi:https://doi.org/10.2337/db06-1726

Contraction Stimulates Nitric Oxide–Independent Microvascular Recruitment and Increases Muscle Insulin Uptake

April C. Inyard; Lucy H. Clerk; Michelle A. Vincent; Eugene J. Barrett

Abstracts

View articletitled, Contraction Stimulates Nitric Oxide–Independent Microvascular Recruitment and Increases Muscle Insulin Uptake

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Topics: insulin , skeletal muscles , hindlimb , electric stimulation , nitric oxide

Diabetes September 2007, Vol.56, 2194-2200. doi:https://doi.org/10.2337/db07-0020

Metallothionein Prevents High-Fat Diet–Induced Cardiac Contractile Dysfunction : Role of Peroxisome Proliferator–Activated Receptor γ Coactivator 1α and Mitochondrial Biogenesis

Feng Dong; Qun Li; Nair Sreejayan; Jennifer M. Nunn; Jun Ren

Abstracts

View articletitled, Metallothionein Prevents High-Fat Diet–Induced Cardiac Contractile Dysfunction : Role of Peroxisome Proliferator–Activated Receptor γ Coactivator 1α and Mitochondrial Biogenesis

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Topics: cardiac myocytes , diet, high-fat , metallothionein , mice , mitochondria

Diabetes September 2007, Vol.56, 2201-2212. doi:https://doi.org/10.2337/db06-1596

Physiological Hyperinsulinemia Has No Detectable Effect on Access of Macromolecules to Insulin-Sensitive Tissues in Healthy Humans

Heinz Weinhandl; Christoph Pachler; Julia K. Mader; Dimas Ikeoka; Agnes Mautner; Andreas Falk; Maria Suppan; Thomas R. Pieber; Martin Ellmerer

Abstracts

View articletitled, Physiological Hyperinsulinemia Has No Detectable Effect on Access of Macromolecules to Insulin-Sensitive Tissues in Healthy Humans

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Topics: hyperinsulinism , insulin , inulin , macromolecule , kinetics

Diabetes September 2007, Vol.56, 2213-2217. doi:https://doi.org/10.2337/db07-0238

Signal Transduction

Characterization of a Protein Kinase B Inhibitor In Vitro and in Insulin-Treated Liver Cells

Lisa Logie; Antonio J. Ruiz-Alcaraz; Michael Keane; Yvonne L. Woods; Jennifer Bain; Rudolfo Marquez; Dario R. Alessi; Calum Sutherland

Abstracts

View articletitled, Characterization of a Protein Kinase B Inhibitor In Vitro and in Insulin-Treated Liver Cells

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Topics: insulin , proto-oncogene proteins c-akt , phosphoenolpyruvate carboxylase , insulin-like growth-factor binding protein 1

Diabetes September 2007, Vol.56, 2218-2227. doi:https://doi.org/10.2337/db07-0343

AMP Kinase Activation Increases Glucose Uptake, Decreases Apoptosis, and Improves Pregnancy Outcome in Embryos Exposed to High IGF-I Concentrations

Grace S. Eng; Rachael A. Sheridan; Amanda Wyman; Maggie M.-Y. Chi; Kristin P. Bibee; Emily S. Jungheim; Kelle H. Moley

Abstracts

View articletitled, AMP Kinase Activation Increases Glucose Uptake, Decreases Apoptosis, and Improves Pregnancy Outcome in Embryos Exposed to High IGF-I Concentrations

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Topics: apoptosis , embryo , insulin-like growth factor i , metformin , insulin

Diabetes September 2007, Vol.56, 2228-2234. doi:https://doi.org/10.2337/db07-0074

Normalization of Prandial Blood Glucose and Improvement of Glucose Tolerance by Liver-Specific Inhibition of SH2 Domain–Containing Inositol Phosphatase 2 (SHIP2) in Diabetic KKA^y Mice : SHIP2 Inhibition Causes Insulin-Mimetic Effects on Glycogen Metabolism, Gluconeogenesis, and Glycolysis

Rolf Grempler; Darya Zibrova; Corinna Schoelch; André van Marle; Joerg F. Rippmann; Norbert Redemann

Abstracts

View articletitled, Normalization of Prandial Blood Glucose and Improvement of Glucose Tolerance by Liver-Specific Inhibition of SH2 Domain–Containing Inositol Phosphatase 2 (SHIP2) in Diabetic KKAy Mice : SHIP2 Inhibition Causes Insulin-Mimetic Effects on Glycogen Metabolism, Gluconeogenesis, and Glycolysis

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Topics: blood glucose , gluconeogenesis , glucose tolerance , insulin , liver

Diabetes September 2007, Vol.56, 2235-2241. doi:https://doi.org/10.2337/db06-1660

Obesity Studies

Absence of CC Chemokine Ligand 2 Does Not Limit Obesity-Associated Infiltration of Macrophages Into Adipose Tissue

Karen E. Inouye; Hang Shi; Jane K. Howard; Christine H. Daly; Graham M. Lord; Barrett J. Rollins; Jeffrey S. Flier

Abstracts

View articletitled, Absence of CC Chemokine Ligand 2 Does Not Limit Obesity-Associated Infiltration of Macrophages Into Adipose Tissue

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Topics: adipose tissue , diet, high-fat , macrophages , mice , monocyte chemoattractant protein-1

Diabetes September 2007, Vol.56, 2242-2250. doi:https://doi.org/10.2337/db07-0425

Immunology and Transplantation

Bone Marrow Is a Preferential Homing Site for Autoreactive T-Cells in Type 1 Diabetes

Ruobing Li; Nicolas Perez; Subha Karumuthil-Melethil; Chenthamarakshan Vasu

Abstracts

View articletitled, Bone Marrow Is a Preferential Homing Site for Autoreactive T-Cells in Type 1 Diabetes

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Topics: antigens , bone marrow , t-lymphocytes , spleen , pancreas

Diabetes September 2007, Vol.56, 2251-2259. doi:https://doi.org/10.2337/db07-0502

Adipocyte-Derived Serum Amyloid A3 and Hyaluronan Play a Role in Monocyte Recruitment and Adhesion

Chang Yeop Han; Savitha Subramanian; Christina K. Chan; Mohamed Omer; Tsuyoshi Chiba; Thomas N. Wight; Alan Chait

Abstracts

View articletitled, Adipocyte-Derived Serum Amyloid A3 and Hyaluronan Play a Role in Monocyte Recruitment and Adhesion

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Topics: adhesions , adipocytes , glucose , hyaluronan , hypertrophy

Diabetes September 2007, Vol.56, 2260-2273. doi:https://doi.org/10.2337/db07-0218

Angiopoietin-1 Production in Islets Improves Islet Engraftment and Protects Islets From Cytokine-Induced Apoptosis

Dongming Su; Nan Zhang; Jing He; Shen Qu; Sandra Slusher; Rita Bottino; Suzanne Bertera; Jonathan Bromberg; H. Henry Dong

Abstracts

View articletitled, Angiopoietin-1 Production in Islets Improves Islet Engraftment and Protects Islets From Cytokine-Induced Apoptosis

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Topics: apoptosis , cytokine , endothelium , glucose , insulin

Diabetes September 2007, Vol.56, 2274-2283. doi:https://doi.org/10.2337/db07-0371

Islet Studies

Impairment of the Ubiquitin-Proteasome Pathway Is a Downstream Endoplasmic Reticulum Stress Response Induced by Extracellular Human Islet Amyloid Polypeptide and Contributes to Pancreatic β-Cell Apoptosis

Sílvia Casas; Ramon Gomis; Fiona M. Gribble; Jordi Altirriba; Sakari Knuutila; Anna Novials

Abstracts

View articletitled, Impairment of the Ubiquitin-Proteasome Pathway Is a Downstream Endoplasmic Reticulum Stress Response Induced by Extracellular Human Islet Amyloid Polypeptide and Contributes to Pancreatic β-Cell Apoptosis

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Topics: apoptosis , multicatalytic endopeptidase complex , endocrine pancreas , stress response , pancreas

Diabetes September 2007, Vol.56, 2284-2294. doi:https://doi.org/10.2337/db07-0178

Metabolic Mechanisms of Failure of Intraportally Transplanted Pancreatic β-Cells in Rats: Role of Lipotoxicity and Prevention by Leptin

Young Lee; Mariella Ravazzola; Byung-Hyun Park; Yuriy K. Bashmakov; Lelio Orci; Roger H. Unger

Abstracts

View articletitled, Metabolic Mechanisms of Failure of Intraportally Transplanted Pancreatic β-Cells in Rats: Role of Lipotoxicity and Prevention by Leptin

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Topics: hepatocytes , insulin , leptin , lipids , liver

Diabetes September 2007, Vol.56, 2295-2301. doi:https://doi.org/10.2337/db07-0460

Distinct In Vivo Roles of Caspase-8 in β-Cells in Physiological and Diabetes Models

Nicole Liadis; Leonardo Salmena; Edwin Kwan; Panteha Tajmir; Stephanie A. Schroer; Anna Radziszewska; Xie Li; Laura Sheu; Mohamed Eweida; Shilong Xu; Herbert Y. Gaisano; Razqallah Hakem; Minna Woo

Abstracts

View articletitled, Distinct In Vivo Roles of Caspase-8 in β-Cells in Physiological and Diabetes Models

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Topics: caspase-8 , insulin , mice

Diabetes September 2007, Vol.56, 2302-2311. doi:https://doi.org/10.2337/db06-1771

Normal Relationship of β- and Non–β-Cells Not Needed for Successful Islet Transplantation

Aileen J.F. King; Justin R. Fernandes; Jennifer Hollister-Lock; Cameron E. Nienaber; Susan Bonner-Weir; Gordon C. Weir

Abstracts

View articletitled, Normal Relationship of β- and Non–β-Cells Not Needed for Successful Islet Transplantation

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Topics: tissue transplants , transplantation , islets of langerhans transplantation , mice , insulin

Diabetes September 2007, Vol.56, 2312-2318. doi:https://doi.org/10.2337/db07-0191

Ghrelin Uses Gα_i2 and Activates Voltage-Dependent K⁺ Channels to Attenuate Glucose-Induced Ca²⁺ Signaling and Insulin Release in Islet β-Cells: Novel Signal Transduction of Ghrelin

Katsuya Dezaki; Masafumi Kakei; Toshihiko Yada

Abstracts

View articletitled, Ghrelin Uses Gαi2 and Activates Voltage-Dependent K+ Channels to Attenuate Glucose-Induced Ca2+ Signaling and Insulin Release in Islet β-Cells: Novel Signal Transduction of Ghrelin

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Topics: ghrelin , glucose , insulin , kilovolt , attenuation

Diabetes September 2007, Vol.56, 2319-2327. doi:https://doi.org/10.2337/db07-0345

Direct Effect of Cholesterol on Insulin Secretion: A Novel Mechanism for Pancreatic β-Cell Dysfunction

Mingming Hao; W. Steven Head; Subhadra C. Gunawardana; Alyssa H. Hasty; David W. Piston

Abstracts

View articletitled, Direct Effect of Cholesterol on Insulin Secretion: A Novel Mechanism for Pancreatic β-Cell Dysfunction

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Topics: cholesterol , glucose , insulin secretion , insulin , cholesterol measurement test

Diabetes September 2007, Vol.56, 2328-2338. doi:https://doi.org/10.2337/db07-0056

Congenital Hyperinsulinism–Associated ABCC8 Mutations That Cause Defective Trafficking of ATP-Sensitive K⁺ Channels: Identification and Rescue

Fei-Fei Yan; Yu-Wen Lin; Courtney MacMullen; Arupa Ganguly; Charles A. Stanley; Show-Ling Shyng

Abstracts

View articletitled, Congenital Hyperinsulinism–Associated ABCC8 Mutations That Cause Defective Trafficking of ATP-Sensitive K+ Channels: Identification and Rescue

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Topics: abcc8 gene , congenital hyperinsulinism , mutation , sulfonylurea compounds , chemiluminescence

Diabetes September 2007, Vol.56, 2339-2348. doi:https://doi.org/10.2337/db07-0150

Pathophysiology

Reduced Expression of Nuclear-Encoded Genes Involved in Mitochondrial Oxidative Metabolism in Skeletal Muscle of Insulin-Resistant Women With Polycystic Ovary Syndrome

Vibe Skov; Dorte Glintborg; Steen Knudsen; Thomas Jensen; Torben A. Kruse; Qihua Tan; Klaus Brusgaard; Henning Beck-Nielsen; Kurt Højlund

Abstracts

View articletitled, Reduced Expression of Nuclear-Encoded Genes Involved in Mitochondrial Oxidative Metabolism in Skeletal Muscle of Insulin-Resistant Women With Polycystic Ovary Syndrome

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Topics: genes , insulin , mitochondria , polycystic ovary syndrome , skeletal muscles

Diabetes September 2007, Vol.56, 2349-2355. doi:https://doi.org/10.2337/db07-0275

Increased Number of Islet-Associated Macrophages in Type 2 Diabetes

Jan A. Ehses; Aurel Perren; Elisabeth Eppler; Pascale Ribaux; John A. Pospisilik; Ranit Maor-Cahn; Xavier Gueripel; Helga Ellingsgaard; Marten K.J. Schneider; Gregoire Biollaz; Adriano Fontana; Manfred Reinecke; Francoise Homo-Delarche; Marc Y. Donath

Abstracts

View articletitled, Increased Number of Islet-Associated Macrophages in Type 2 Diabetes

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Topics: chemokines , cytokine , diabetes mellitus, type 2 , endocrine pancreas , glucose

Diabetes September 2007, Vol.56, 2356-2370. doi:https://doi.org/10.2337/db06-1650

Complications

The Vascular Ectonucleotidase ENTPD1 Is a Novel Renoprotective Factor in Diabetic Nephropathy

David J. Friedman; Helmut G. Rennke; Eva Csizmadia; Keiichi Enjyoji; Simon C. Robson

Abstracts

View articletitled, The Vascular Ectonucleotidase ENTPD1 Is a Novel Renoprotective Factor in Diabetic Nephropathy

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Topics: adenosine , diabetic nephropathy , entpd1 gene , kidney glomerulus , mice

Diabetes September 2007, Vol.56, 2371-2379. doi:https://doi.org/10.2337/db06-1593

Proteolytic Degradation of VE-Cadherin Alters the Blood-Retinal Barrier in Diabetes

Deepti Navaratna; Paul G. McGuire; Gina Menicucci; Arup Das

Abstracts

View articletitled, Proteolytic Degradation of VE-Cadherin Alters the Blood-Retinal Barrier in Diabetes

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Topics: cadherins , endothelial cells , permeability , matrix metalloproteinases , gelatinase b

Diabetes September 2007, Vol.56, 2380-2387. doi:https://doi.org/10.2337/db06-1694

Genetics

Alcohol Consumption and Type 2 Diabetes: Influence of Genetic Variation in Alcohol Dehydrogenase

Joline W.J. Beulens; Eric B. Rimm; Henk F.J. Hendriks; Frank B. Hu; JoAnn E. Manson; David J. Hunter; Kenneth J. Mukamal

Abstracts

View articletitled, Alcohol Consumption and Type 2 Diabetes: Influence of Genetic Variation in Alcohol Dehydrogenase

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Topics: alcohol dehydrogenase , alcohol drinking , diabetes mellitus, type 2 , ethanol , genotype

Diabetes September 2007, Vol.56, 2388-2394. doi:https://doi.org/10.2337/db07-0181

Brief Reports

Hepatic Lipin 1β Expression Is Diminished in Insulin-Resistant Obese Subjects and Is Reactivated by Marked Weight Loss

Michelle A. Croce; J. Christopher Eagon; Lori L. LaRiviere; Kevin M. Korenblat; Samuel Klein; Brian N. Finck

Abstracts

View articletitled, Hepatic Lipin 1β Expression Is Diminished in Insulin-Resistant Obese Subjects and Is Reactivated by Marked Weight Loss

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Topics: insulin , insulin resistance , obesity , weight reduction , adipose tissue

Diabetes September 2007, Vol.56, 2395-2399. doi:https://doi.org/10.2337/db07-0480

Screening for Insulitis in Adult Autoantibody-Positive Organ Donors

Peter In't Veld; Dirk Lievens; Joeri De Grijse; Zhidong Ling; Bart Van der Auwera; Miriam Pipeleers-Marichal; Frans Gorus; Daniel Pipeleers

Abstracts

View articletitled, Screening for Insulitis in Adult Autoantibody-Positive Organ Donors

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Topics: antibodies , autoantibodies , diabetes mellitus, type 1 , donors , insulin

Diabetes September 2007, Vol.56, 2400-2404. doi:https://doi.org/10.2337/db07-0416

HLA-DPB10402 Protects Against Type 1A Diabetes Autoimmunity in the Highest Risk DR3-DQB10201/DR4-DQB1*0302 DAISY Population

Erin E. Baschal; Theresa A. Aly; Sunanda R. Babu; Maria S. Fernando; Liping Yu; Dongmei Miao; Katherine J. Barriga; Jill M. Norris; Janelle A. Noble; Henry A. Erlich; Marian J. Rewers; George S. Eisenbarth

Abstracts

View articletitled, HLA-DPB1*0402 Protects Against Type 1A Diabetes Autoimmunity in the Highest Risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY Population

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Topics: alleles , autoantibodies , autoimmunity , child , human leukocyte antigens

Diabetes September 2007, Vol.56, 2405-2409. doi:https://doi.org/10.2337/db07-0029

A CTG Polymorphism in the CNDP1 Gene Determines the Secretion of Serum Carnosinase in Cos-7–Transfected Cells

Eva Riedl; Hannes Koeppel; Paul Brinkkoetter; Paula Sternik; Herbert Steinbeisser; Sibylle Sauerhoefer; Bart Janssen; Fokko J. van der Woude; Benito A. Yard

Abstracts

View articletitled, A CTG Polymorphism in the CNDP1 Gene Determines the Secretion of Serum Carnosinase in Cos-7–Transfected Cells

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Topics: bodily secretions , diabetic nephropathy , genes , peptides , polymorphism

Diabetes September 2007, Vol.56, 2410-2413. doi:https://doi.org/10.2337/db07-0128

Online Letters to the Editor

Comment on: Hosagai et al. (2007) Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation: Diabetes 56:901–911

Paul Trayhurn; Bohan Wang; I. Stuart Wood

Extract

View articletitled, Comment on: Hosagai et al. (2007) Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation: Diabetes 56:901–911

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Topics: adipokines , adipose tissue , hypoxia , obesity

Diabetes September 2007, Vol.56, e14. doi:https://doi.org/10.2337/db07-0747

Comment on: Harmancey et al. (2007) Adrenomedullin Inhibits Adipogenesis Under Transcriptional Control of Insulin: Diabetes 56:553–563

Kazuhiro Takahashi

Extract

View articletitled, Comment on: Harmancey et al. (2007) Adrenomedullin Inhibits Adipogenesis Under Transcriptional Control of Insulin: Diabetes 56:553–563

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Topics: adrenomedullin , insulin , transcriptional control

Diabetes September 2007, Vol.56, e15. doi:https://doi.org/10.2337/db07-0592

Comment on: Marchand and Polychronakos (2007) Evaluation of Polymorphic Splicing in the Mechanism of the Association of the Insulin Gene with Diabetes: Diabetes 56:709–713

Santiago Rodriguez; Tom R. Gaunt; Igoř Vorechovský; Jana Kralovičová; Peter J. Wood; Ian N.M. Day

Extract

View articletitled, Comment on: Marchand and Polychronakos (2007) Evaluation of Polymorphic Splicing in the Mechanism of the Association of the Insulin Gene with Diabetes: Diabetes 56:709–713

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Topics: genes , insulin , rna splicing

Diabetes September 2007, Vol.56, e16. doi:https://doi.org/10.2337/db07-0805

Response to Comment on: Marchand and Polychronakos (2007) Evaluation of Polymorphic Splicing in the Mechanism of the Association of the Insulin Gene with Diabetes: Diabetes 56:709–713

Luc Marchand; Constantin Polychronakos

Extract

View articletitled, Response to Comment on: Marchand and Polychronakos (2007) Evaluation of Polymorphic Splicing in the Mechanism of the Association of the Insulin Gene with Diabetes: Diabetes 56:709–713

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Topics: genes , insulin , rna splicing

Diabetes September 2007, Vol.56, e17. doi:https://doi.org/10.2337/db07-0836

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