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Volume 56, Issue 9
September 2007
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ISSN 0012-1797
EISSN 1939-327X
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Metabolism

Neuregulins Increase Mitochondrial Oxidative Capacity and Insulin Sensitivity in Skeletal Muscle Cells
Carles Cantó; Sara Pich; José C. Paz; Rosario Sanches; Vicente Martínez; Meritxell Orpinell; Manuel Palacín; Antonio Zorzano; Anna Gumà
View articletitled, Neuregulins Increase Mitochondrial Oxidative Capacity and Insulin Sensitivity in Skeletal Muscle Cells
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Diabetes September 2007, Vol.56, 2185-2193. doi:https://doi.org/10.2337/db06-1726
Contraction Stimulates Nitric Oxide–Independent Microvascular Recruitment and Increases Muscle Insulin Uptake
April C. Inyard; Lucy H. Clerk; Michelle A. Vincent; Eugene J. Barrett
View articletitled, Contraction Stimulates Nitric Oxide–Independent Microvascular Recruitment and Increases Muscle Insulin Uptake
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Diabetes September 2007, Vol.56, 2194-2200. doi:https://doi.org/10.2337/db07-0020
Metallothionein Prevents High-Fat Diet–Induced Cardiac Contractile Dysfunction : Role of Peroxisome Proliferator–Activated Receptor γ Coactivator 1α and Mitochondrial Biogenesis
Feng Dong; Qun Li; Nair Sreejayan; Jennifer M. Nunn; Jun Ren
View articletitled, Metallothionein Prevents High-Fat Diet–Induced Cardiac Contractile Dysfunction <span class="subtitle-colon">: </span><span class="subtitle">Role of Peroxisome Proliferator–Activated Receptor γ Coactivator 1α and Mitochondrial Biogenesis</span>
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Diabetes September 2007, Vol.56, 2201-2212. doi:https://doi.org/10.2337/db06-1596
Physiological Hyperinsulinemia Has No Detectable Effect on Access of Macromolecules to Insulin-Sensitive Tissues in Healthy Humans
Heinz Weinhandl; Christoph Pachler; Julia K. Mader; Dimas Ikeoka; Agnes Mautner; Andreas Falk; Maria Suppan; Thomas R. Pieber; Martin Ellmerer
View articletitled, Physiological Hyperinsulinemia Has No Detectable Effect on Access of Macromolecules to Insulin-Sensitive Tissues in Healthy Humans
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Diabetes September 2007, Vol.56, 2213-2217. doi:https://doi.org/10.2337/db07-0238

Signal Transduction

Characterization of a Protein Kinase B Inhibitor In Vitro and in Insulin-Treated Liver Cells
Lisa Logie; Antonio J. Ruiz-Alcaraz; Michael Keane; Yvonne L. Woods; Jennifer Bain; Rudolfo Marquez; Dario R. Alessi; Calum Sutherland
View articletitled, Characterization of a Protein Kinase B Inhibitor In Vitro and in Insulin-Treated Liver Cells
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Diabetes September 2007, Vol.56, 2218-2227. doi:https://doi.org/10.2337/db07-0343
AMP Kinase Activation Increases Glucose Uptake, Decreases Apoptosis, and Improves Pregnancy Outcome in Embryos Exposed to High IGF-I Concentrations
Grace S. Eng; Rachael A. Sheridan; Amanda Wyman; Maggie M.-Y. Chi; Kristin P. Bibee; Emily S. Jungheim; Kelle H. Moley
View articletitled, AMP Kinase Activation Increases Glucose Uptake, Decreases Apoptosis, and Improves Pregnancy Outcome in Embryos Exposed to High IGF-I Concentrations
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Diabetes September 2007, Vol.56, 2228-2234. doi:https://doi.org/10.2337/db07-0074
Normalization of Prandial Blood Glucose and Improvement of Glucose Tolerance by Liver-Specific Inhibition of SH2 Domain–Containing Inositol Phosphatase 2 (SHIP2) in Diabetic KKAy Mice : SHIP2 Inhibition Causes Insulin-Mimetic Effects on Glycogen Metabolism, Gluconeogenesis, and Glycolysis
Rolf Grempler; Darya Zibrova; Corinna Schoelch; André van Marle; Joerg F. Rippmann; Norbert Redemann
View articletitled, Normalization of Prandial Blood Glucose and Improvement of Glucose Tolerance by Liver-Specific Inhibition of SH2 Domain–Containing Inositol Phosphatase 2 (SHIP2) in Diabetic KKA<sup>y</sup> Mice <span class="subtitle-colon">: </span><span class="subtitle">SHIP2 Inhibition Causes Insulin-Mimetic Effects on Glycogen Metabolism, Gluconeogenesis, and Glycolysis</span>
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Diabetes September 2007, Vol.56, 2235-2241. doi:https://doi.org/10.2337/db06-1660

Obesity Studies

Absence of CC Chemokine Ligand 2 Does Not Limit Obesity-Associated Infiltration of Macrophages Into Adipose Tissue
Karen E. Inouye; Hang Shi; Jane K. Howard; Christine H. Daly; Graham M. Lord; Barrett J. Rollins; Jeffrey S. Flier
View articletitled, Absence of CC Chemokine Ligand 2 Does Not Limit Obesity-Associated Infiltration of Macrophages Into Adipose Tissue
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Diabetes September 2007, Vol.56, 2242-2250. doi:https://doi.org/10.2337/db07-0425

Immunology and Transplantation

Bone Marrow Is a Preferential Homing Site for Autoreactive T-Cells in Type 1 Diabetes
Ruobing Li; Nicolas Perez; Subha Karumuthil-Melethil; Chenthamarakshan Vasu
View articletitled, Bone Marrow Is a Preferential Homing Site for Autoreactive T-Cells in Type 1 Diabetes
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Diabetes September 2007, Vol.56, 2251-2259. doi:https://doi.org/10.2337/db07-0502
Adipocyte-Derived Serum Amyloid A3 and Hyaluronan Play a Role in Monocyte Recruitment and Adhesion
Chang Yeop Han; Savitha Subramanian; Christina K. Chan; Mohamed Omer; Tsuyoshi Chiba; Thomas N. Wight; Alan Chait
View articletitled, Adipocyte-Derived Serum Amyloid A3 and Hyaluronan Play a Role in Monocyte Recruitment and Adhesion
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Diabetes September 2007, Vol.56, 2260-2273. doi:https://doi.org/10.2337/db07-0218
Angiopoietin-1 Production in Islets Improves Islet Engraftment and Protects Islets From Cytokine-Induced Apoptosis
Dongming Su; Nan Zhang; Jing He; Shen Qu; Sandra Slusher; Rita Bottino; Suzanne Bertera; Jonathan Bromberg; H. Henry Dong
View articletitled, Angiopoietin-1 Production in Islets Improves Islet Engraftment and Protects Islets From Cytokine-Induced Apoptosis
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Diabetes September 2007, Vol.56, 2274-2283. doi:https://doi.org/10.2337/db07-0371

Islet Studies

Impairment of the Ubiquitin-Proteasome Pathway Is a Downstream Endoplasmic Reticulum Stress Response Induced by Extracellular Human Islet Amyloid Polypeptide and Contributes to Pancreatic β-Cell Apoptosis
Sílvia Casas; Ramon Gomis; Fiona M. Gribble; Jordi Altirriba; Sakari Knuutila; Anna Novials
View articletitled, Impairment of the Ubiquitin-Proteasome Pathway Is a Downstream Endoplasmic Reticulum Stress Response Induced by Extracellular Human Islet Amyloid Polypeptide and Contributes to Pancreatic β-Cell Apoptosis
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Diabetes September 2007, Vol.56, 2284-2294. doi:https://doi.org/10.2337/db07-0178
Metabolic Mechanisms of Failure of Intraportally Transplanted Pancreatic β-Cells in Rats: Role of Lipotoxicity and Prevention by Leptin
Young Lee; Mariella Ravazzola; Byung-Hyun Park; Yuriy K. Bashmakov; Lelio Orci; Roger H. Unger
View articletitled, Metabolic Mechanisms of Failure of Intraportally Transplanted Pancreatic β-Cells in Rats<span class="subtitle-colon">: </span><span class="subtitle">Role of Lipotoxicity and Prevention by Leptin</span>
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Diabetes September 2007, Vol.56, 2295-2301. doi:https://doi.org/10.2337/db07-0460
Distinct In Vivo Roles of Caspase-8 in β-Cells in Physiological and Diabetes Models
Nicole Liadis; Leonardo Salmena; Edwin Kwan; Panteha Tajmir; Stephanie A. Schroer; Anna Radziszewska; Xie Li; Laura Sheu; Mohamed Eweida; Shilong Xu; Herbert Y. Gaisano; Razqallah Hakem; Minna Woo
View articletitled, Distinct In Vivo Roles of Caspase-8 in β-Cells in Physiological and Diabetes Models
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Diabetes September 2007, Vol.56, 2302-2311. doi:https://doi.org/10.2337/db06-1771
Normal Relationship of β- and Non–β-Cells Not Needed for Successful Islet Transplantation
Aileen J.F. King; Justin R. Fernandes; Jennifer Hollister-Lock; Cameron E. Nienaber; Susan Bonner-Weir; Gordon C. Weir
View articletitled, Normal Relationship of β- and Non–β-Cells Not Needed for Successful Islet Transplantation
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Diabetes September 2007, Vol.56, 2312-2318. doi:https://doi.org/10.2337/db07-0191
Ghrelin Uses Gαi2 and Activates Voltage-Dependent K+ Channels to Attenuate Glucose-Induced Ca2+ Signaling and Insulin Release in Islet β-Cells: Novel Signal Transduction of Ghrelin
Katsuya Dezaki; Masafumi Kakei; Toshihiko Yada
View articletitled, Ghrelin Uses Gα<sub>i2</sub> and Activates Voltage-Dependent K<sup>+</sup> Channels to Attenuate Glucose-Induced Ca<sup>2+</sup> Signaling and Insulin Release in Islet β-Cells<span class="subtitle-colon">: </span><span class="subtitle">Novel Signal Transduction of Ghrelin</span>
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Diabetes September 2007, Vol.56, 2319-2327. doi:https://doi.org/10.2337/db07-0345
Direct Effect of Cholesterol on Insulin Secretion: A Novel Mechanism for Pancreatic β-Cell Dysfunction
Mingming Hao; W. Steven Head; Subhadra C. Gunawardana; Alyssa H. Hasty; David W. Piston
View articletitled, Direct Effect of Cholesterol on Insulin Secretion<span class="subtitle-colon">: </span><span class="subtitle">A Novel Mechanism for Pancreatic β-Cell Dysfunction</span>
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Diabetes September 2007, Vol.56, 2328-2338. doi:https://doi.org/10.2337/db07-0056
Congenital Hyperinsulinism–Associated ABCC8 Mutations That Cause Defective Trafficking of ATP-Sensitive K+ Channels: Identification and Rescue
Fei-Fei Yan; Yu-Wen Lin; Courtney MacMullen; Arupa Ganguly; Charles A. Stanley; Show-Ling Shyng
View articletitled, Congenital Hyperinsulinism–Associated <em>ABCC8</em> Mutations That Cause Defective Trafficking of ATP-Sensitive K<sup>+</sup> Channels<span class="subtitle-colon">: </span><span class="subtitle">Identification and Rescue</span>
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Diabetes September 2007, Vol.56, 2339-2348. doi:https://doi.org/10.2337/db07-0150

Pathophysiology

Reduced Expression of Nuclear-Encoded Genes Involved in Mitochondrial Oxidative Metabolism in Skeletal Muscle of Insulin-Resistant Women With Polycystic Ovary Syndrome
Vibe Skov; Dorte Glintborg; Steen Knudsen; Thomas Jensen; Torben A. Kruse; Qihua Tan; Klaus Brusgaard; Henning Beck-Nielsen; Kurt Højlund
View articletitled, Reduced Expression of Nuclear-Encoded Genes Involved in Mitochondrial Oxidative Metabolism in Skeletal Muscle of Insulin-Resistant Women With Polycystic Ovary Syndrome
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Diabetes September 2007, Vol.56, 2349-2355. doi:https://doi.org/10.2337/db07-0275
Increased Number of Islet-Associated Macrophages in Type 2 Diabetes
Jan A. Ehses; Aurel Perren; Elisabeth Eppler; Pascale Ribaux; John A. Pospisilik; Ranit Maor-Cahn; Xavier Gueripel; Helga Ellingsgaard; Marten K.J. Schneider; Gregoire Biollaz; Adriano Fontana; Manfred Reinecke; Francoise Homo-Delarche; Marc Y. Donath
View articletitled, Increased Number of Islet-Associated Macrophages in Type 2 Diabetes
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Diabetes September 2007, Vol.56, 2356-2370. doi:https://doi.org/10.2337/db06-1650

Complications

The Vascular Ectonucleotidase ENTPD1 Is a Novel Renoprotective Factor in Diabetic Nephropathy
David J. Friedman; Helmut G. Rennke; Eva Csizmadia; Keiichi Enjyoji; Simon C. Robson
View articletitled, The Vascular Ectonucleotidase ENTPD1 Is a Novel Renoprotective Factor in Diabetic Nephropathy
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Diabetes September 2007, Vol.56, 2371-2379. doi:https://doi.org/10.2337/db06-1593
Proteolytic Degradation of VE-Cadherin Alters the Blood-Retinal Barrier in Diabetes
Deepti Navaratna; Paul G. McGuire; Gina Menicucci; Arup Das
View articletitled, Proteolytic Degradation of VE-Cadherin Alters the Blood-Retinal Barrier in Diabetes
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Diabetes September 2007, Vol.56, 2380-2387. doi:https://doi.org/10.2337/db06-1694

Genetics

Alcohol Consumption and Type 2 Diabetes: Influence of Genetic Variation in Alcohol Dehydrogenase
Joline W.J. Beulens; Eric B. Rimm; Henk F.J. Hendriks; Frank B. Hu; JoAnn E. Manson; David J. Hunter; Kenneth J. Mukamal
View articletitled, Alcohol Consumption and Type 2 Diabetes<span class="subtitle-colon">: </span><span class="subtitle">Influence of Genetic Variation in Alcohol Dehydrogenase</span>
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Diabetes September 2007, Vol.56, 2388-2394. doi:https://doi.org/10.2337/db07-0181

Brief Reports

Hepatic Lipin 1β Expression Is Diminished in Insulin-Resistant Obese Subjects and Is Reactivated by Marked Weight Loss
Michelle A. Croce; J. Christopher Eagon; Lori L. LaRiviere; Kevin M. Korenblat; Samuel Klein; Brian N. Finck
View articletitled, Hepatic Lipin 1β Expression Is Diminished in Insulin-Resistant Obese Subjects and Is Reactivated by Marked Weight Loss
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Diabetes September 2007, Vol.56, 2395-2399. doi:https://doi.org/10.2337/db07-0480
Screening for Insulitis in Adult Autoantibody-Positive Organ Donors
Peter In't Veld; Dirk Lievens; Joeri De Grijse; Zhidong Ling; Bart Van der Auwera; Miriam Pipeleers-Marichal; Frans Gorus; Daniel Pipeleers
View articletitled, Screening for Insulitis in Adult Autoantibody-Positive Organ Donors
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Diabetes September 2007, Vol.56, 2400-2404. doi:https://doi.org/10.2337/db07-0416
HLA-DPB1*0402 Protects Against Type 1A Diabetes Autoimmunity in the Highest Risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY Population
Erin E. Baschal; Theresa A. Aly; Sunanda R. Babu; Maria S. Fernando; Liping Yu; Dongmei Miao; Katherine J. Barriga; Jill M. Norris; Janelle A. Noble; Henry A. Erlich; Marian J. Rewers; George S. Eisenbarth
View articletitled, HLA-DPB1*0402 Protects Against Type 1A Diabetes Autoimmunity in the Highest Risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY Population
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Diabetes September 2007, Vol.56, 2405-2409. doi:https://doi.org/10.2337/db07-0029
A CTG Polymorphism in the CNDP1 Gene Determines the Secretion of Serum Carnosinase in Cos-7–Transfected Cells
Eva Riedl; Hannes Koeppel; Paul Brinkkoetter; Paula Sternik; Herbert Steinbeisser; Sibylle Sauerhoefer; Bart Janssen; Fokko J. van der Woude; Benito A. Yard
View articletitled, A CTG Polymorphism in the CNDP1 Gene Determines the Secretion of Serum Carnosinase in Cos-7–Transfected Cells
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Diabetes September 2007, Vol.56, 2410-2413. doi:https://doi.org/10.2337/db07-0128

Online Letters to the Editor

Comment on: Hosagai et al. (2007) Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation: Diabetes 56:901–911
Paul Trayhurn; Bohan Wang; I. Stuart Wood
View articletitled, Comment on: Hosagai et al. (2007) Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation: <em>Diabetes</em> 56:901–911
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Diabetes September 2007, Vol.56, e14. doi:https://doi.org/10.2337/db07-0747
Comment on: Harmancey et al. (2007) Adrenomedullin Inhibits Adipogenesis Under Transcriptional Control of Insulin: Diabetes 56:553–563
Kazuhiro Takahashi
View articletitled, Comment on: Harmancey et al. (2007) Adrenomedullin Inhibits Adipogenesis Under Transcriptional Control of Insulin: <em>Diabetes</em> 56:553–563
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Diabetes September 2007, Vol.56, e15. doi:https://doi.org/10.2337/db07-0592
Comment on: Marchand and Polychronakos (2007) Evaluation of Polymorphic Splicing in the Mechanism of the Association of the Insulin Gene with Diabetes: Diabetes 56:709–713
Santiago Rodriguez; Tom R. Gaunt; Igoř Vorechovský; Jana Kralovičová; Peter J. Wood; Ian N.M. Day
View articletitled, Comment on: Marchand and Polychronakos (2007) Evaluation of Polymorphic Splicing in the Mechanism of the Association of the Insulin Gene with Diabetes: <em>Diabetes</em> 56:709–713
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Diabetes September 2007, Vol.56, e16. doi:https://doi.org/10.2337/db07-0805
Response to Comment on: Marchand and Polychronakos (2007) Evaluation of Polymorphic Splicing in the Mechanism of the Association of the Insulin Gene with Diabetes: Diabetes 56:709–713
Luc Marchand; Constantin Polychronakos
View articletitled, Response to Comment on: Marchand and Polychronakos (2007) Evaluation of Polymorphic Splicing in the Mechanism of the Association of the Insulin Gene with Diabetes: <em>Diabetes</em> 56:709–713
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Diabetes September 2007, Vol.56, e17. doi:https://doi.org/10.2337/db07-0836
MRI Metrics of Cerebral Endothelial Cell–Derived Exosomes for the Treatment of Cognitive Dysfunction Induced in Aging Rats Subjected to Type 2 Diabetes
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
227-OR: Tirzepatide Reduces HbA1c and Body Weight Significantly More than Placebo Regardless of Insulin Sensitivity and Beta-Cell Function—Post Hoc Analysis from SURMOUNT-2
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