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Commentaries

An Apparent Role for Alox15 in the Pathogenesis of Diabetes in the NOD Mouse : Parsing the Supporting Genetic Data

Stuart P. Weisberg; Rudolph L. Leibel

Abstracts

View articletitled, An Apparent Role for Alox15 in the Pathogenesis of Diabetes in the NOD Mouse : Parsing the Supporting Genetic Data

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Topics: arachidonate 15-lipoxygenase , genetics , mice, inbred nod , mice

Diabetes January 2008, Vol.57, 1-2. doi:https://doi.org/10.2337/db07-1592

Diabetes and Protein Metabolism

Niels Møller; K. Sreekumaran Nair

Abstracts

View articletitled, Diabetes and Protein Metabolism

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Topics: glucose , insulin , protein metabolism , amino acids , insulin resistance

Diabetes January 2008, Vol.57, 3-4. doi:https://doi.org/10.2337/db07-1581

Metabolism

Defective Lipid Delivery Modulates Glucose Tolerance and Metabolic Response to Diet in Apolipoprotein E–Deficient Mice

Susanna M. Hofmann; Diego Perez-Tilve; Todd M. Greer; Beth A. Coburn; Erin Grant; Joshua E. Basford; Matthias H. Tschöp; David Y. Hui

Abstracts

View articletitled, Defective Lipid Delivery Modulates Glucose Tolerance and Metabolic Response to Diet in Apolipoprotein E–Deficient Mice

Supplementary data

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Topics: apolipoprotein e , diet , lipids , mice , glucose

Diabetes January 2008, Vol.57, 5-12. doi:https://doi.org/10.2337/db07-0403

Denervation and High-Fat Diet Reduce Insulin Signaling in T-Tubules in Skeletal Muscle of Living Mice

Hans P.M. Mortensen Lauritzen; Thorkil Ploug; Hua Ai; Morten Donsmark; Clara Prats; Henrik Galbo

Abstracts

View articletitled, Denervation and High-Fat Diet Reduce Insulin Signaling in T-Tubules in Skeletal Muscle of Living Mice

Supplementary data

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Topics: denervation , diet, high-fat , insulin , mice , transverse tubule of muscle cell

Diabetes January 2008, Vol.57, 13-23. doi:https://doi.org/10.2337/db07-0516

Comparison of the Effects of Pioglitazone and Metformin on Hepatic and Extra-Hepatic Insulin Action in People With Type 2 Diabetes

Rita Basu; Pankaj Shah; Ananda Basu; Barbara Norby; Betty Dicke; Visvanathan Chandramouli; Ohad Cohen; Bernard R. Landau; Robert A. Rizza

Abstracts

View articletitled, Comparison of the Effects of Pioglitazone and Metformin on Hepatic and Extra-Hepatic Insulin Action in People With Type 2 Diabetes

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Topics: diabetes mellitus, type 2 , glucose , insulin , metformin , metformin/pioglitazone

Diabetes January 2008, Vol.57, 24-31. doi:https://doi.org/10.2337/db07-0827

Fatty Acids and Insulin Modulate Myocardial Substrate Metabolism in Humans With Type 1 Diabetes

Linda R. Peterson; Pilar Herrero; Janet McGill; Kenneth B. Schechtman; Zulfia Kisrieva-Ware; Donna Lesniak; Robert J. Gropler

Abstracts

View articletitled, Fatty Acids and Insulin Modulate Myocardial Substrate Metabolism in Humans With Type 1 Diabetes

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Topics: diabetes mellitus, type 1 , fatty acids , insulin , myocardium , plasma

Diabetes January 2008, Vol.57, 32-40. doi:https://doi.org/10.2337/db07-1199

Inactivation of Glyceraldehyde-3-Phosphate Dehydrogenase by Fumarate in Diabetes: Formation of S-(2-Succinyl)Cysteine, a Novel Chemical Modification of Protein and Possible Biomarker of Mitochondrial Stress

Matthew Blatnik; Norma Frizzell; Suzanne R. Thorpe; John W. Baynes

Abstracts

View articletitled, Inactivation of Glyceraldehyde-3-Phosphate Dehydrogenase by Fumarate in Diabetes: Formation of S-(2-Succinyl)Cysteine, a Novel Chemical Modification of Protein and Possible Biomarker of Mitochondrial Stress

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Topics: cysteine , fumarates , peptides , liquid chromatography

Diabetes January 2008, Vol.57, 41-49. doi:https://doi.org/10.2337/db07-0838

Evidence That Processes Other Than Gluconeogenesis May Influence the Ratio of Deuterium on the Fifth and Third Carbons of Glucose : Implications for the Use of ²H₂O to Measure Gluconeogenesis in Humans

Gerlies Bock; William C. Schumann; Rita Basu; Shawn C. Burgess; Zheng Yan; Visvanathan Chandramouli; Robert A. Rizza; Bernard R. Landau

Abstracts

View articletitled, Evidence That Processes Other Than Gluconeogenesis May Influence the Ratio of Deuterium on the Fifth and Third Carbons of Glucose : Implications for the Use of 2H2O to Measure Gluconeogenesis in Humans

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Topics: deuterium , glucose , gluconeogenesis , insulin , transaldolase

Diabetes January 2008, Vol.57, 50-55. doi:https://doi.org/10.2337/db07-0694

Insulin Resistance of Protein Metabolism in Type 2 Diabetes

Sandra Pereira; Errol B. Marliss; José A. Morais; Stéphanie Chevalier; Réjeanne Gougeon

Abstracts

View articletitled, Insulin Resistance of Protein Metabolism in Type 2 Diabetes

Supplementary data

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Topics: diabetes mellitus, type 2 , glucose , insulin , insulin resistance , leucine

Diabetes January 2008, Vol.57, 56-63. doi:https://doi.org/10.2337/db07-0887

Acute Diabetes Moderates Trafficking of Cardiac Lipoprotein Lipase Through p38 Mitogen-Activated Protein Kinase–Dependent Actin Cytoskeleton Organization

Min Suk Kim; Girish Kewalramani; Prasanth Puthanveetil; Vivian Lee; Ujendra Kumar; Ding An; Ashraf Abrahani; Brian Rodrigues

Abstracts

View articletitled, Acute Diabetes Moderates Trafficking of Cardiac Lipoprotein Lipase Through p38 Mitogen-Activated Protein Kinase–Dependent Actin Cytoskeleton Organization

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Topics: actins , ampk , cardiac myocytes , mitogen-activated protein kinase p38 , muscle cells

Diabetes January 2008, Vol.57, 64-76. doi:https://doi.org/10.2337/db07-0832

Signal Transduction

Resistance to Diet-Induced Obesity and Improved Insulin Sensitivity in Mice With a Regulator of G Protein Signaling–Insensitive G184S Gnai2 Allele

Xinyan Huang; Raelene A. Charbeneau; Ying Fu; Kuljeet Kaur; Isabelle Gerin; Ormond A. MacDougald; Richard R. Neubig

Abstracts

View articletitled, Resistance to Diet-Induced Obesity and Improved Insulin Sensitivity in Mice With a Regulator of G Protein Signaling–Insensitive G184S Gnai2 Allele

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Topics: diet , mice , obesity , gtp-binding proteins , insulin sensitivity

Diabetes January 2008, Vol.57, 77-85. doi:https://doi.org/10.2337/db07-0599

Obesity Studies

In Vivo Evidence for Inverse Agonism of Agouti-Related Peptide in the Central Nervous System of Proopiomelanocortin-Deficient Mice

Virginie Tolle; Malcolm J. Low

Abstracts

View articletitled, In Vivo Evidence for Inverse Agonism of Agouti-Related Peptide in the Central Nervous System of Proopiomelanocortin-Deficient Mice

Supplementary data

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Topics: agouti-related protein , mice , pro-opiomelanocortin

Diabetes January 2008, Vol.57, 86-94. doi:https://doi.org/10.2337/db07-0733

Low Physical Activity Accentuates the Effect of the FTO rs9939609 Polymorphism on Body Fat Accumulation

Camilla H. Andreasen; Kirstine L. Stender-Petersen; Mette S. Mogensen; Signe S. Torekov; Lise Wegner; Gitte Andersen; Arne L. Nielsen; Anders Albrechtsen; Knut Borch-Johnsen; Signe S. Rasmussen; Jesper O. Clausen; Annelli Sandbæk; Torsten Lauritzen; Lars Hansen; Torben Jørgensen; Oluf Pedersen; Torben Hansen

Abstracts

View articletitled, Low Physical Activity Accentuates the Effect of the FTO rs9939609 Polymorphism on Body Fat Accumulation

Supplementary data

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Topics: body fat , body mass index procedure , fto gene , genotype , obesity

Diabetes January 2008, Vol.57, 95-101. doi:https://doi.org/10.2337/db07-0910

Immunology and Transplantation

Stromal Cell–Derived Factor-1/CXCL12 Stimulates Chemorepulsion of NOD/LtJ T-Cell Adhesion to Islet Microvascular Endothelium

Christopher D. Sharp; Meng Huang; John Glawe; D. Ross Patrick; Sible Pardue; Shayne C. Barlow; Christopher G. Kevil

Abstracts

View articletitled, Stromal Cell–Derived Factor-1/CXCL12 Stimulates Chemorepulsion of NOD/LtJ T-Cell Adhesion to Islet Microvascular Endothelium

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Topics: adhesions , stromal cell-derived factor 1 , t-lymphocytes , cell adhesion molecules , endothelium

Diabetes January 2008, Vol.57, 102-112. doi:https://doi.org/10.2337/db07-0494

Functional Waning of Naturally Occurring CD4⁺ Regulatory T-Cells Contributes to the Onset of Autoimmune Diabetes

Michael Tritt; Evridiki Sgouroudis; Eva d'Hennezel; Alexandre Albanese; Ciriaco A. Piccirillo

Abstracts

View articletitled, Functional Waning of Naturally Occurring CD4+ Regulatory T-Cells Contributes to the Onset of Autoimmune Diabetes

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Topics: antigens, cd25 , diabetes mellitus, type 1 , foxp3 gene , mice , mice, inbred nod

Diabetes January 2008, Vol.57, 113-123. doi:https://doi.org/10.2337/db06-1700

Islet Studies

The Role of Nitric Oxide and the Unfolded Protein Response in Cytokine-Induced β-Cell Death

Kari T. Chambers; Julie A. Unverferth; Sarah M. Weber; Ronald C. Wek; Fumihiko Urano; John A. Corbett

Abstracts

View articletitled, The Role of Nitric Oxide and the Unfolded Protein Response in Cytokine-Induced β-Cell Death

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Topics: caspase-3 , cytokine , interleukin-1 , transcriptional activation , tunicamycin

Diabetes January 2008, Vol.57, 124-132. doi:https://doi.org/10.2337/db07-0944

Long-Range Enhancers Are Required to Maintain Expression of the Autoantigen Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein in Adult Mouse Islets In Vivo

Yingda Wang; Brian P. Flemming; Cyrus C. Martin; Shelley R. Allen; Jay Walters; James K. Oeser; John C. Hutton; Richard M. O'Brien

Abstracts

View articletitled, Long-Range Enhancers Are Required to Maintain Expression of the Autoantigen Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein in Adult Mouse Islets In Vivo

Supplementary data

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Topics: enhancer of transcription , genes , glucose-6-phosphatase , mice , mice, transgenic

Diabetes January 2008, Vol.57, 133-141. doi:https://doi.org/10.2337/db07-0092

Partial Pancreatectomy in Adult Humans Does Not Provoke β-Cell Regeneration

Bjoern A. Menge; Andrea Tannapfel; Orlin Belyaev; Robert Drescher; Christophe Müller; Waldemar Uhl; Wolfgang E. Schmidt; Juris J. Meier

Abstracts

View articletitled, Partial Pancreatectomy in Adult Humans Does Not Provoke β-Cell Regeneration

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Topics: pancreas , pancreatectomy , pancreatic resection , insulin

Diabetes January 2008, Vol.57, 142-149. doi:https://doi.org/10.2337/db07-1294

Pathophysiology

MT1-MMP Expression in First-Trimester Placental Tissue Is Upregulated in Type 1 Diabetes as a Result of Elevated Insulin and Tumor Necrosis Factor-α Levels

Ursula Hiden; Elisabeth Glitzner; Marina Ivanisevic; Josip Djelmis; Christian Wadsack; Uwe Lang; Gernot Desoye

Abstracts

View articletitled, MT1-MMP Expression in First-Trimester Placental Tissue Is Upregulated in Type 1 Diabetes as a Result of Elevated Insulin and Tumor Necrosis Factor-α Levels

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Topics: insulin , matrix metalloproteinases , placenta , pregnancy trimester, first , trophoblasts

Diabetes January 2008, Vol.57, 150-157. doi:https://doi.org/10.2337/db07-0903

Electronegative LDL Impairs Vascular Endothelial Cell Integrity in Diabetes by Disrupting Fibroblast Growth Factor 2 (FGF2) Autoregulation

Jonathan Lu; Wei Jiang; Jun-Hai Yang; Po-Yuan Chang; Jeffrey P. Walterscheid; Hsin-Hung Chen; Marco Marcelli; Daming Tang; Yuan-Teh Lee; Warren S.L. Liao; Chao-Yuh Yang; Chu-Huang Chen

Abstracts

View articletitled, Electronegative LDL Impairs Vascular Endothelial Cell Integrity in Diabetes by Disrupting Fibroblast Growth Factor 2 (FGF2) Autoregulation

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Topics: fibroblast growth factor 2 , proto-oncogene proteins c-akt , low-density lipoproteins , apoptosis

Diabetes January 2008, Vol.57, 158-166. doi:https://doi.org/10.2337/db07-1287

Endothelial Dysfunction and C-Reactive Protein Are Risk Factors for Diabetes in Essential Hypertension

Francesco Perticone; Raffele Maio; Angela Sciacqua; Francesco Andreozzi; Giuseppina Iemma; Maria Perticone; Carmine Zoccali; Giorgio Sesti

Abstracts

View articletitled, Endothelial Dysfunction and C-Reactive Protein Are Risk Factors for Diabetes in Essential Hypertension

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Topics: acetylcholine , c-reactive protein , diabetes mellitus, type 2 , endothelial dysfunction , endothelium

Diabetes January 2008, Vol.57, 167-171. doi:https://doi.org/10.2337/db07-1189

Complications

Expression of N^G,N^G-Dimethylarginine Dimethylaminohydrolase and Protein Arginine N-Methyltransferase Isoforms in Diabetic Rat Kidney: Effects of Angiotensin II Receptor Blockers

Maristela L. Onozato; Akihiro Tojo; James Leiper; Toshiro Fujita; Fredrik Palm; Christopher S. Wilcox

Abstracts

View articletitled, Expression of NG,NG-Dimethylarginine Dimethylaminohydrolase and Protein Arginine N-Methyltransferase Isoforms in Diabetic Rat Kidney: Effects of Angiotensin II Receptor Blockers

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Topics: angiotensin ii , kidney , n,n-dimethylarginine , protein isoforms , rats

Diabetes January 2008, Vol.57, 172-180. doi:https://doi.org/10.2337/db06-1772

Neuritin Mediates Nerve Growth Factor–Induced Axonal Regeneration and Is Deficient in Experimental Diabetic Neuropathy

Eugenia Karamoysoyli; Rebecca C. Burnand; David R. Tomlinson; Natalie J. Gardiner

Abstracts

View articletitled, Neuritin Mediates Nerve Growth Factor–Induced Axonal Regeneration and Is Deficient in Experimental Diabetic Neuropathy

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Topics: diabetic neuropathies , nerve growth factors , neuronal outgrowth , neurons , neurons, afferent

Diabetes January 2008, Vol.57, 181-189. doi:https://doi.org/10.2337/db07-0895

Pharmacology and Therapeutics

Differential Antidiabetic Efficacy of Incretin Agonists Versus DPP-4 Inhibition in High Fat–Fed Mice

Benjamin J. Lamont; Daniel J. Drucker

Abstracts

View articletitled, Differential Antidiabetic Efficacy of Incretin Agonists Versus DPP-4 Inhibition in High Fat–Fed Mice

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Topics: agonists , dipeptidyl-peptidase iv , incretin , insulin , mice

Diabetes January 2008, Vol.57, 190-198. doi:https://doi.org/10.2337/db07-1202

Genetics

Nonobese Diabetic (NOD) Mice Congenic for a Targeted Deletion of 12/15-Lipoxygenase Are Protected From Autoimmune Diabetes

Marcia McDuffie; Nelly A. Maybee; Susanna R. Keller; Brian K. Stevens; James C. Garmey; Margaret A. Morris; Elizabeth Kropf; Claudia Rival; Kaiwen Ma; Jeffrey D. Carter; Sarah A. Tersey; Craig S. Nunemaker; Jerry L. Nadler

Abstracts

View articletitled, Nonobese Diabetic (NOD) Mice Congenic for a Targeted Deletion of 12/15-Lipoxygenase Are Protected From Autoimmune Diabetes

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Topics: arachidonate 15-lipoxygenase , mice , mice, knockout , macrophages

Diabetes January 2008, Vol.57, 199-208. doi:https://doi.org/10.2337/db07-0830

Genetic Variants Within the LPIN1 Gene, Encoding Lipin, Are Influencing Phenotypes of the Metabolic Syndrome in Humans

Silke Wiedmann; Marcus Fischer; Martina Koehler; Katharina Neureuther; Guenter Riegger; Angela Doering; Heribert Schunkert; Christian Hengstenberg; Andrea Baessler

Abstracts

View articletitled, Genetic Variants Within the LPIN1 Gene, Encoding Lipin, Are Influencing Phenotypes of the Metabolic Syndrome in Humans

Supplementary data

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Topics: haplotypes , metabolic syndrome x , phenotype , single nucleotide polymorphism , obesity

Diabetes January 2008, Vol.57, 209-217. doi:https://doi.org/10.2337/db07-0083

Multiple Superoxide Dismutase 1/Splicing Factor Serine Alanine 15 Variants Are Associated With the Development and Progression of Diabetic Nephropathy: The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Genetics Study

Abstracts

View articletitled, Multiple Superoxide Dismutase 1/Splicing Factor Serine Alanine 15 Variants Are Associated With the Development and Progression of Diabetic Nephropathy: The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Genetics Study

Supplementary data

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Topics: dcct trial , edic trial , single nucleotide polymorphism , sod1 gene , kidney diseases

Diabetes January 2008, Vol.57, 218-228. doi:https://doi.org/10.2337/db07-1059

Further Evidence of a Primary, Causal Association of the PTPN22 620W Variant With Type 1 Diabetes

Magdalena Zoledziewska; Chiara Perra; Valeria Orrù; Loredana Moi; Paola Frongia; Mauro Congia; Nunzio Bottini; Francesco Cucca

Abstracts

View articletitled, Further Evidence of a Primary, Causal Association of the PTPN22 620W Variant With Type 1 Diabetes

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Topics: diabetes mellitus, type 1 , polymorphism , alleles , genes , disease association

Diabetes January 2008, Vol.57, 229-234. doi:https://doi.org/10.2337/db07-0289

Genome-Wide Scan for Estimated Glomerular Filtration Rate in Multi-Ethnic Diabetic Populations: The Family Investigation of Nephropathy and Diabetes (FIND)

Abstracts

View articletitled, Genome-Wide Scan for Estimated Glomerular Filtration Rate in Multi-Ethnic Diabetic Populations: The Family Investigation of Nephropathy and Diabetes (FIND)

Supplementary data

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Topics: diabetic nephropathy , family studies , genome , glomerular filtration rate, estimated , kidney diseases

Diabetes January 2008, Vol.57, 235-243. doi:https://doi.org/10.2337/db07-0313

Impact of Common Type 2 Diabetes Risk Polymorphisms in the DESIR Prospective Study

Martine Vaxillaire; Jacques Veslot; Christian Dina; Christine Proença; Stéphane Cauchi; Guillaume Charpentier; Jean Tichet; Frédéric Fumeron; Michel Marre; David Meyre; Beverley Balkau; Philippe Froguel; for the DESIR Study Group

Abstracts

View articletitled, Impact of Common Type 2 Diabetes Risk Polymorphisms in the DESIR Prospective Study

Supplementary data

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Topics: desir cohort , diabetes mellitus, type 2 , interleukin-6 , hyperglycemia , impaired fasting glucose

Diabetes January 2008, Vol.57, 244-254. doi:https://doi.org/10.2337/db07-0615

Mosaic Paternal Uniparental Isodisomy and an ABCC8 Gene Mutation in a Patient With Permanent Neonatal Diabetes and Hemihypertrophy

Julian P.H. Shield; Sarah E. Flanagan; Deborah J. Mackay; Lorna W. Harries; Peter Proks; Christophe Girard; Frances M. Ashcroft; I. Karen Temple; Sian Ellard

Abstracts

View articletitled, Mosaic Paternal Uniparental Isodisomy and an ABCC8 Gene Mutation in a Patient With Permanent Neonatal Diabetes and Hemihypertrophy

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Topics: abcc8 gene , hemihypertrophy, congenital , mosaicism , mutation , neonatal diabetes mellitus

Diabetes January 2008, Vol.57, 255-258. doi:https://doi.org/10.2337/db07-0999

An ABCC8 Gene Mutation and Mosaic Uniparental Isodisomy Resulting in Atypical Diffuse Congenital Hyperinsulinism

Khalid Hussain; Sarah E. Flanagan; Virpi V. Smith; Michael Ashworth; Michael Day; Agostino Pierro; Sian Ellard

Abstracts

View articletitled, An ABCC8 Gene Mutation and Mosaic Uniparental Isodisomy Resulting in Atypical Diffuse Congenital Hyperinsulinism

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Topics: abcc8 gene , atypical , congenital hyperinsulinism , dna , mosaicism

Diabetes January 2008, Vol.57, 259-263. doi:https://doi.org/10.2337/db07-0998

Variants in the Fat Mass–and Obesity-Associated (FTO) Gene Are Not Associated With Obesity in a Chinese Han Population

Huaixing Li; Ying Wu; Ruth J.F. Loos; Frank B. Hu; Yong Liu; Jing Wang; Zhijie Yu; Xu Lin

Abstracts

View articletitled, Variants in the Fat Mass–and Obesity-Associated (FTO) Gene Are Not Associated With Obesity in a Chinese Han Population

Supplementary data

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Topics: fto gene , obesity , diabetes mellitus, type 2 , single nucleotide polymorphism , genes

Diabetes January 2008, Vol.57, 264-268. doi:https://doi.org/10.2337/db07-1130

Unaltered Diabetes Presentation in NOD Mice Lacking the Vitamin D Receptor

Conny Gysemans; Evelyne van Etten; Lutgart Overbergh; Annapaula Giulietti; Guy Eelen; Mark Waer; Annemieke Verstuyf; Roger Bouillon; Chantal Mathieu

Abstracts

View articletitled, Unaltered Diabetes Presentation in NOD Mice Lacking the Vitamin D Receptor

Supplementary data

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Topics: mice, inbred nod , vitamin d3 receptor , phenotype , vitamin d , ligands

Diabetes January 2008, Vol.57, 269-275. doi:https://doi.org/10.2337/db07-1095

Online Letters to the Editor

Comment on: Knop et al. (2007) Reduced Incretin Effect in Type 2 Diabetes: Cause or Consequence of the Diabetic State? Diabetes 56:1951–1959

Simeon Pierre Choukem; Jean-François Gautier

Extract

View articletitled, Comment on: Knop et al. (2007) Reduced Incretin Effect in Type 2 Diabetes: Cause or Consequence of the Diabetic State? Diabetes 56:1951–1959

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Topics: diabetes mellitus, type 2 , incretin

Diabetes January 2008, Vol.57, e1. doi:https://doi.org/10.2337/db07-1470

Response to Comment on: Knop et al. (2007) Reduced Incretin Effect in Type 2 Diabetes: Cause or Consequence of the Diabetic State? Diabetes 56:1951–1959

Filip K. Knop; Tina Vilsbøll; Sten Madsbad; Thure Krarup; Jens J. Holst

Abstracts

View articletitled, Response to Comment on: Knop et al. (2007) Reduced Incretin Effect in Type 2 Diabetes: Cause or Consequence of the Diabetic State? Diabetes 56:1951–1959

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Topics: diabetes mellitus, type 2 , glucagon-like peptide 1 , incretin , bodily secretions , hormones

Diabetes January 2008, Vol.57, e2-e3. doi:https://doi.org/10.2337/db07-1522

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