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Issues
Perspectives in Diabetes
The “Perfect Storm” for Type 1 Diabetes: The Complex Interplay Between Intestinal Microbiota, Gut Permeability, and Mucosal Immunity
Diabetes October 2008, Vol.57, 2555-2562. doi:https://doi.org/10.2337/db08-0331
Commentaries
Vitamin D and Type 2 Diabetes: Are We Ready for a Prevention Trial?
Diabetes October 2008, Vol.57, 2565-2566. doi:https://doi.org/10.2337/db08-0879
Role of MicroRNA in Pancreatic β-Cells: Where More Is Less
Diabetes October 2008, Vol.57, 2567-2568. doi:https://doi.org/10.2337/db08-0934
Metabolism
Metabolism-Independent Sugar Sensing in Central Orexin Neurons
Diabetes October 2008, Vol.57, 2569-2576. doi:https://doi.org/10.2337/db08-0548
Brain Glucagon-Like Peptide-1 Regulates Arterial Blood Flow, Heart Rate, and Insulin Sensitivity
Cendrine Cabou; Gérard Campistron; Nicolas Marsollier; Corinne Leloup; Celine Cruciani-Guglielmacci; Luc Pénicaud; Daniel J. Drucker; Christophe Magnan; Rémy Burcelin
Diabetes October 2008, Vol.57, 2577-2587. doi:https://doi.org/10.2337/db08-0121
Cerebral Blood Flow and Cerebral Edema in Rats With Diabetic Ketoacidosis
Diabetes October 2008, Vol.57, 2588-2594. doi:https://doi.org/10.2337/db07-1410
Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects
Sara M. Reyna; Sangeeta Ghosh; Puntip Tantiwong; C.S. Reddy Meka; Phyllis Eagan; Christopher P. Jenkinson; Eugenio Cersosimo; Ralph A. DeFronzo; Dawn K. Coletta; Apiradee Sriwijitkamol; Nicolas Musi
Diabetes October 2008, Vol.57, 2595-2602. doi:https://doi.org/10.2337/db08-0038
Role of Central Nervous System Glucagon-Like Peptide-1 Receptors in Enteric Glucose Sensing
Claude Knauf; Patrice D. Cani; Dong-Hoon Kim; Miguel A. Iglesias; Chantal Chabo; Aurélie Waget; André Colom; Sophie Rastrelli; Nathalie M. Delzenne; Daniel J. Drucker; Randy J. Seeley; Remy Burcelin
Diabetes October 2008, Vol.57, 2603-2612. doi:https://doi.org/10.2337/db07-1788
Physical Activity and Insulin Sensitivity: The RISC Study
Beverley Balkau; Leila Mhamdi; Jean-Michel Oppert; John Nolan; Alain Golay; Francesca Porcellati; Markku Laakso; Ele Ferrannini; on behalf of the EGIR-RISC Study Group
Diabetes October 2008, Vol.57, 2613-2618. doi:https://doi.org/10.2337/db07-1605
Signal Transduction
Integrin-Associated Protein Association With Src Homology 2 Domain Containing Tyrosine Phosphatase Substrate 1 Regulates IGF-I Signaling In Vivo
Diabetes October 2008, Vol.57, 2637-2643. doi:https://doi.org/10.2337/db08-0326
Muscle-Specific IRS-1 Ser→Ala Transgenic Mice Are Protected From Fat-Induced Insulin Resistance in Skeletal Muscle
Katsutaro Morino; Susanne Neschen; Stefan Bilz; Saki Sono; Dimitrios Tsirigotis; Richard M. Reznick; Irene Moore; Yoshio Nagai; Varman Samuel; David Sebastian; Morris White; William Philbrick; Gerald I. Shulman
Diabetes October 2008, Vol.57, 2644-2651. doi:https://doi.org/10.2337/db06-0454
Obesity Studies
Impaired Glucose Tolerance and Insulin Resistance Are Associated With Increased Adipose 11β-Hydroxysteroid Dehydrogenase Type 1 Expression and Elevated Hepatic 5α-Reductase Activity
Jeremy W. Tomlinson; Joanne Finney; Christopher Gay; Beverly A. Hughes; Susan V. Hughes; Paul M. Stewart
Diabetes October 2008, Vol.57, 2652-2660. doi:https://doi.org/10.2337/db08-0495
Diurnal Variation of Human Sweet Taste Recognition Thresholds Is Correlated With Plasma Leptin Levels
Yuki Nakamura; Keisuke Sanematsu; Rie Ohta; Shinya Shirosaki; Kiyoshi Koyano; Kazuaki Nonaka; Noriatsu Shigemura; Yuzo Ninomiya
Diabetes October 2008, Vol.57, 2661-2665. doi:https://doi.org/10.2337/db07-1103
Immunology and Transplantation
Simultaneous Islet and Kidney Transplantation in Seven Patients With Type 1 Diabetes and End-Stage Renal Disease Using a Glucocorticoid-Free Immunosuppressive Regimen With Alemtuzumab Induction
Jianming Tan; Shunliang Yang; Jinquan Cai; Junqi Guo; Lianghu Huang; Zhixian Wu; Jin Chen; Lianming Liao
Diabetes October 2008, Vol.57, 2666-2671. doi:https://doi.org/10.2337/db08-0358
CD28/CD154 Blockade Prevents Autoimmune Diabetes by Inducing Nondeletional Tolerance After Effector T-Cell Inhibition and Regulatory T-Cell Expansion
Diabetes October 2008, Vol.57, 2672-2683. doi:https://doi.org/10.2337/db07-1712
Transforming Growth Factor-β Suppresses the Activation of CD8+ T-Cells When Naïve but Promotes Their Survival and Function Once Antigen Experienced : A Two-Faced Impact on Autoimmunity
Christophe M. Filippi; Amy E. Juedes; Janine E. Oldham; Ellie Ling; Lisa Togher; Yufeng Peng; Richard A. Flavell; Matthias G. von Herrath
Diabetes October 2008, Vol.57, 2684-2692. doi:https://doi.org/10.2337/db08-0609
A Common Nonsynonymous Single Nucleotide Polymorphism in the SLC30A8 Gene Determines ZnT8 Autoantibody Specificity in Type 1 Diabetes
Janet M. Wenzlau; Yu Liu; Liping Yu; Ong Moua; Kimberly T. Fowler; Sampathkumar Rangasamy; Jay Walters; George S. Eisenbarth; Howard W. Davidson; John C. Hutton
Diabetes October 2008, Vol.57, 2693-2697. doi:https://doi.org/10.2337/db08-0522
Islet Studies
Decreased Fetal Size Is Associated With β-Cell Hyperfunction in Early Life and Failure With Age
Manu V. Chakravarthy; Yimin Zhu; Mitchell B. Wice; Trey Coleman; Kirk L. Pappan; Connie A. Marshall; Michael L. McDaniel; Clay F. Semenkovich
Diabetes October 2008, Vol.57, 2698-2707. doi:https://doi.org/10.2337/db08-0404
miR-375 Targets 3′-Phosphoinositide–Dependent Protein Kinase-1 and Regulates Glucose-Induced Biological Responses in Pancreatic β-Cells
Abdelfattah El Ouaamari; Nadine Baroukh; Geert A. Martens; Patricia Lebrun; Daniel Pipeleers; Emmanuel van Obberghen
Diabetes October 2008, Vol.57, 2708-2717. doi:https://doi.org/10.2337/db07-1614
Postnatal Expansion of the Pancreatic β-Cell Mass Is Dependent on Survivin
Yuying Jiang; Wataru Nishimura; Deborah Devor-Henneman; Donna Kusewitt; Haijuan Wang; Michael P. Holloway; Takehiko Dohi; Edmond Sabo; Michael L. Robinson; Dario C. Altieri; Arun Sharma; Rachel A. Altura
Diabetes October 2008, Vol.57, 2718-2727. doi:https://doi.org/10.2337/db08-0170
Alterations in MicroRNA Expression Contribute to Fatty Acid–Induced Pancreatic β-Cell Dysfunction
Pascal Lovis; Elodie Roggli; D. Ross Laybutt; Sonia Gattesco; Jiang-Yan Yang; Christian Widmann; Amar Abderrahmani; Romano Regazzi
Diabetes October 2008, Vol.57, 2728-2736. doi:https://doi.org/10.2337/db07-1252
Spontaneous Diabetes in Hemizygous Human Amylin Transgenic Mice That Developed Neither Islet Amyloid nor Peripheral Insulin Resistance
Winifred P.S. Wong; David W. Scott; Chia-Lin Chuang; Shaoping Zhang; Hong Liu; Athena Ferreira; Etuate L. Saafi; Yee Soon Choong; Garth J.S. Cooper
Diabetes October 2008, Vol.57, 2737-2744. doi:https://doi.org/10.2337/db06-1755
Hepatocyte Growth Factor Enhances Engraftment and Function of Nonhuman Primate Islets
Nathalie M. Fiaschi-Taesch; Dora M. Berman; Brian M. Sicari; Karen K. Takane; Adolfo Garcia-Ocaña; Camillo Ricordi; Norma S. Kenyon; Andrew F. Stewart
Diabetes October 2008, Vol.57, 2745-2754. doi:https://doi.org/10.2337/db07-1085
Mouse Pancreatic Endocrine Cell Transcriptome Defined in the Embryonic Ngn3-Null Mouse
Diabetes October 2008, Vol.57, 2755-2761. doi:https://doi.org/10.2337/db07-1126
Pathophysiology
Plasma Fetuin-A Levels and the Risk of Type 2 Diabetes
Norbert Stefan; Andreas Fritsche; Cornelia Weikert; Heiner Boeing; Hans-Georg Joost; Hans-Ulrich Häring; Matthias B. Schulze
Diabetes October 2008, Vol.57, 2762-2767. doi:https://doi.org/10.2337/db08-0538
Distinct Monocyte Gene-Expression Profiles in Autoimmune Diabetes
Roos C. Padmos; Nanette C. Schloot; Huriya Beyan; Cindy Ruwhof; Frank J.T. Staal; Dick de Ridder; Henk-Jan Aanstoot; Wai Kwan Lam-Tse; Harm de Wit; Christian de Herder; Roos C. Drexhage; Barbara Menart; R. David Leslie; Hemmo A. Drexhage; the LADA Consortium
Diabetes October 2008, Vol.57, 2768-2773. doi:https://doi.org/10.2337/db08-0496
Complications
Neuronatin: A New Inflammation Gene Expressed on the Aortic Endothelium of Diabetic Mice
Diabetes October 2008, Vol.57, 2774-2783. doi:https://doi.org/10.2337/db07-1746
Potent Inhibition of Cicatricial Contraction in Proliferative Vitreoretinal Diseases by Statins
Shuhei Kawahara; Yasuaki Hata; Takeshi Kita; Ryoichi Arita; Muneki Miura; Shintaro Nakao; Yasutaka Mochizuki; Hiroshi Enaida; Tadahisa Kagimoto; Yoshinobu Goto; Ali Hafezi-Moghadam; Tatsuro Ishibashi
Diabetes October 2008, Vol.57, 2784-2793. doi:https://doi.org/10.2337/db08-0302
Correction of HDL Dysfunction in Individuals With Diabetes and the Haptoglobin 2-2 Genotype
Rabea Asleh; Shany Blum; Shiri Kalet-Litman; Jonia Alshiek; Rachel Miller-Lotan; Roy Asaf; Wasseem Rock; Michael Aviram; Uzi Milman; Chen Shapira; Zaid Abassi; Andrew P. Levy
Diabetes October 2008, Vol.57, 2794-2800. doi:https://doi.org/10.2337/db08-0450
Sulfasalazine Blocks the Development of Tactile Allodynia in Diabetic Rats
Diabetes October 2008, Vol.57, 2801-2808. doi:https://doi.org/10.2337/db07-1274
Activation of NF-E2–Related Factor-2 Reverses Biochemical Dysfunction of Endothelial Cells Induced by Hyperglycemia Linked to Vascular Disease
Mingzhan Xue; Qingwen Qian; Antonysunil Adaikalakoteswari; Naila Rabbani; Roya Babaei-Jadidi; Paul J. Thornalley
Diabetes October 2008, Vol.57, 2809-2817. doi:https://doi.org/10.2337/db06-1003
Impaired Collateral Recruitment and Outward Remodeling in Experimental Diabetes
Jolanda M. van Golde; Matthijs S. Ruiter; Nicolaas C. Schaper; Stefan Vöö; Johannes Waltenberger; Walter H. Backes; Mark J. Post; Maya S. Huijberts
Diabetes October 2008, Vol.57, 2818-2823. doi:https://doi.org/10.2337/db08-0229
Inducible Overexpression of sFlt-1 in Podocytes Ameliorates Glomerulopathy in Diabetic Mice
Ching-Hsin Ku; Kathryn E. White; Alessandra Dei Cas; Anthea Hayward; Zoe Webster; Rudy Bilous; Sally Marshall; Giancarlo Viberti; Luigi Gnudi
Diabetes October 2008, Vol.57, 2824-2833. doi:https://doi.org/10.2337/db08-0647
Genetics
Common Variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE Genes Are Associated With Type 2 Diabetes and Impaired Fasting Glucose in a Chinese Han Population
Ying Wu; Huaixing Li; Ruth J.F. Loos; Zhijie Yu; Xingwang Ye; Lihua Chen; An Pan; Frank B. Hu; Xu Lin
Diabetes October 2008, Vol.57, 2834-2842. doi:https://doi.org/10.2337/db08-0047
G/T Substitution in Intron 1 of the UNC13B Gene Is Associated With Increased Risk of Nephropathy in Patients With Type 1 Diabetes
David-Alexandre Trégouet; Per-Henrik Groop; Steven McGinn; Carol Forsblom; Samy Hadjadj; Michel Marre; Hans-Henrik Parving; Lise Tarnow; Ralph Telgmann; Tiphaine Godefroy; Viviane Nicaud; Rachel Rousseau; Maikki Parkkonen; Anna Hoverfält; Ivo Gut; Simon Heath; Fumihiko Matsuda; Roger Cox; Gbenga Kazeem; Martin Farrall; Dominique Gauguier; Stefan-Martin Brand-Herrmann; François Cambien; Mark Lathrop; Nathalie Vionnet; for the EURAGEDIC Consortium
Diabetes October 2008, Vol.57, 2843-2850. doi:https://doi.org/10.2337/db08-0073
FTO Variants Are Associated With Obesity in the Chinese and Malay Populations in Singapore
Jonathan T. Tan; Rajkumar Dorajoo; Mark Seielstad; Xue Ling Sim; Rick Twee-Hee Ong; Kee Seng Chia; Tien Yin Wong; Seang Mei Saw; Suok Kai Chew; Tin Aung; E-Shyong Tai
Diabetes October 2008, Vol.57, 2851-2857. doi:https://doi.org/10.2337/db08-0214
A Human Type 1 Diabetes Susceptibility Locus Maps to Chromosome 21q22.3
Patrick Concannon; Suna Onengut-Gumuscu; John A. Todd; Deborah J. Smyth; Flemming Pociot; Regine Bergholdt; Beena Akolkar; Henry A. Erlich; Joan E. Hilner; Cécile Julier; Grant Morahan; Jørn Nerup; Concepcion R. Nierras; Wei-Min Chen; Stephen S. Rich; the Type 1 Diabetes Genetics Consortium
Diabetes October 2008, Vol.57, 2858-2861. doi:https://doi.org/10.2337/db08-0753