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Perspectives in Diabetes

The “Perfect Storm” for Type 1 Diabetes: The Complex Interplay Between Intestinal Microbiota, Gut Permeability, and Mucosal Immunity

Outi Vaarala; Mark A. Atkinson; Josef Neu

Abstracts

View articletitled, The “Perfect Storm” for Type 1 Diabetes: The Complex Interplay Between Intestinal Microbiota, Gut Permeability, and Mucosal Immunity

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Topics: diabetes mellitus, type 1 , intestines , microbiome , permeability

Diabetes October 2008, Vol.57, 2555-2562. doi:https://doi.org/10.2337/db08-0331

Commentaries

Mary, Mary, Quite Contrary, How Do Your β-Cells Fail?

Jack L. Leahy

Abstracts

View articletitled, Mary, Mary, Quite Contrary, How Do Your β-Cells Fail?

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Topics: diabetes mellitus, type 2 , glucose , insulin , insulin secretion , mice

Diabetes October 2008, Vol.57, 2563-2564. doi:https://doi.org/10.2337/db08-0869

Vitamin D and Type 2 Diabetes: Are We Ready for a Prevention Trial?

Robert Scragg

Abstracts

View articletitled, Vitamin D and Type 2 Diabetes: Are We Ready for a Prevention Trial?

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Topics: diabetes mellitus, type 2 , vitamin d

Diabetes October 2008, Vol.57, 2565-2566. doi:https://doi.org/10.2337/db08-0879

Role of MicroRNA in Pancreatic β-Cells: Where More Is Less

Michael D. Walker

Abstracts

View articletitled, Role of MicroRNA in Pancreatic β-Cells: Where More Is Less

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Topics: micrornas , pancreas

Diabetes October 2008, Vol.57, 2567-2568. doi:https://doi.org/10.2337/db08-0934

Metabolism

Metabolism-Independent Sugar Sensing in Central Orexin Neurons

J. Antonio González; Lise T. Jensen; Lars Fugger; Denis Burdakov

Abstracts

View articletitled, Metabolism-Independent Sugar Sensing in Central Orexin Neurons

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Topics: glucose , neurons , orexins , sugars , deoxyglucose

Diabetes October 2008, Vol.57, 2569-2576. doi:https://doi.org/10.2337/db08-0548

Brain Glucagon-Like Peptide-1 Regulates Arterial Blood Flow, Heart Rate, and Insulin Sensitivity

Cendrine Cabou; Gérard Campistron; Nicolas Marsollier; Corinne Leloup; Celine Cruciani-Guglielmacci; Luc Pénicaud; Daniel J. Drucker; Christophe Magnan; Rémy Burcelin

Abstracts

View articletitled, Brain Glucagon-Like Peptide-1 Regulates Arterial Blood Flow, Heart Rate, and Insulin Sensitivity

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Topics: arterial blood , brain , glucagon-like peptide 1 , glucagon-like peptide-1 receptor , glucose

Diabetes October 2008, Vol.57, 2577-2587. doi:https://doi.org/10.2337/db08-0121

Cerebral Blood Flow and Cerebral Edema in Rats With Diabetic Ketoacidosis

Natalie Yuen; Steven E. Anderson; Nicole Glaser; Daniel J. Tancredi; Martha E. O'Donnell

Abstracts

View articletitled, Cerebral Blood Flow and Cerebral Edema in Rats With Diabetic Ketoacidosis

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Topics: diabetic ketoacidosis , rats , insulin , bumetanide , saline solutions

Diabetes October 2008, Vol.57, 2588-2594. doi:https://doi.org/10.2337/db07-1410

Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects

Sara M. Reyna; Sangeeta Ghosh; Puntip Tantiwong; C.S. Reddy Meka; Phyllis Eagan; Christopher P. Jenkinson; Eugenio Cersosimo; Ralph A. DeFronzo; Dawn K. Coletta; Apiradee Sriwijitkamol; Nicolas Musi

Abstracts

View articletitled, Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects

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Topics: insulin , palmitates , signal transduction , toll-like receptor 4 , skeletal myocytes

Diabetes October 2008, Vol.57, 2595-2602. doi:https://doi.org/10.2337/db08-0038

Role of Central Nervous System Glucagon-Like Peptide-1 Receptors in Enteric Glucose Sensing

Claude Knauf; Patrice D. Cani; Dong-Hoon Kim; Miguel A. Iglesias; Chantal Chabo; Aurélie Waget; André Colom; Sophie Rastrelli; Nathalie M. Delzenne; Daniel J. Drucker; Randy J. Seeley; Remy Burcelin

Abstracts

View articletitled, Role of Central Nervous System Glucagon-Like Peptide-1 Receptors in Enteric Glucose Sensing

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Topics: glucose , infusion procedures , intragastric route , c-fos genes

Diabetes October 2008, Vol.57, 2603-2612. doi:https://doi.org/10.2337/db07-1788

Physical Activity and Insulin Sensitivity: The RISC Study

Beverley Balkau; Leila Mhamdi; Jean-Michel Oppert; John Nolan; Alain Golay; Francesca Porcellati; Markku Laakso; Ele Ferrannini; on behalf of the EGIR-RISC Study Group

Abstracts

View articletitled, Physical Activity and Insulin Sensitivity: The RISC Study

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Topics: accelerometers , insulin sensitivity , lack of exercise

Diabetes October 2008, Vol.57, 2613-2618. doi:https://doi.org/10.2337/db07-1605

Signal Transduction

Baseline Serum 25-Hydroxy Vitamin D Is Predictive of Future Glycemic Status and Insulin Resistance : The Medical Research Council Ely Prospective Study 1990–2000

Nita G. Forouhi; Jian'an Luan; Andrew Cooper; Barbara J. Boucher; Nicholas J. Wareham

Abstracts

View articletitled, Baseline Serum 25-Hydroxy Vitamin D Is Predictive of Future Glycemic Status and Insulin Resistance : The Medical Research Council Ely Prospective Study 1990–2000

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Topics: deuterium , fasting , fasting blood glucose measurement , follow-up , glucose

Diabetes October 2008, Vol.57, 2619-2625. doi:https://doi.org/10.2337/db08-0593

Mechanism of Oxidative DNA Damage in Diabetes : Tuberin Inactivation and Downregulation of DNA Repair Enzyme 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine-DNA Glycosylase

Simona Simone; Yves Gorin; Chakradhar Velagapudi; Hanna E. Abboud; Samy L. Habib

Abstracts

View articletitled, Mechanism of Oxidative DNA Damage in Diabetes : Tuberin Inactivation and Downregulation of DNA Repair Enzyme 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine-DNA Glycosylase

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Topics: 8-hydroxy-2'-deoxyguanosine , down-regulation , glucose , phosphorylation , proto-oncogene proteins c-akt

Diabetes October 2008, Vol.57, 2626-2636. doi:https://doi.org/10.2337/db07-1579

Integrin-Associated Protein Association With Src Homology 2 Domain Containing Tyrosine Phosphatase Substrate 1 Regulates IGF-I Signaling In Vivo

Laura A. Maile; Byron E. Capps; Emily C. Miller; Ariel W. Aday; David R. Clemmons

Abstracts

View articletitled, Integrin-Associated Protein Association With Src Homology 2 Domain Containing Tyrosine Phosphatase Substrate 1 Regulates IGF-I Signaling In Vivo

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Topics: hyperglycemia , hyperglycemic agents , insulin-like growth factor i , mice , aorta

Diabetes October 2008, Vol.57, 2637-2643. doi:https://doi.org/10.2337/db08-0326

Muscle-Specific IRS-1 Ser→Ala Transgenic Mice Are Protected From Fat-Induced Insulin Resistance in Skeletal Muscle

Katsutaro Morino; Susanne Neschen; Stefan Bilz; Saki Sono; Dimitrios Tsirigotis; Richard M. Reznick; Irene Moore; Yoshio Nagai; Varman Samuel; David Sebastian; Morris White; William Philbrick; Gerald I. Shulman

Abstracts

View articletitled, Muscle-Specific IRS-1 Ser→Ala Transgenic Mice Are Protected From Fat-Induced Insulin Resistance in Skeletal Muscle

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Topics: insulin , irs1 protein, human , mice , insulin resistance , diet, high-fat

Diabetes October 2008, Vol.57, 2644-2651. doi:https://doi.org/10.2337/db06-0454

Obesity Studies

Impaired Glucose Tolerance and Insulin Resistance Are Associated With Increased Adipose 11β-Hydroxysteroid Dehydrogenase Type 1 Expression and Elevated Hepatic 5α-Reductase Activity

Jeremy W. Tomlinson; Joanne Finney; Christopher Gay; Beverly A. Hughes; Susan V. Hughes; Paul M. Stewart

Abstracts

View articletitled, Impaired Glucose Tolerance and Insulin Resistance Are Associated With Increased Adipose 11β-Hydroxysteroid Dehydrogenase Type 1 Expression and Elevated Hepatic 5α-Reductase Activity

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Topics: adipose tissue , biopsy , cortisone , diabetes mellitus, type 2 , fasting

Diabetes October 2008, Vol.57, 2652-2660. doi:https://doi.org/10.2337/db08-0495

Diurnal Variation of Human Sweet Taste Recognition Thresholds Is Correlated With Plasma Leptin Levels

Yuki Nakamura; Keisuke Sanematsu; Rie Ohta; Shinya Shirosaki; Kiyoshi Koyano; Kazuaki Nonaka; Noriatsu Shigemura; Yuzo Ninomiya

Abstracts

View articletitled, Diurnal Variation of Human Sweet Taste Recognition Thresholds Is Correlated With Plasma Leptin Levels

Supplementary data

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Topics: leptin , plasma , taste perception , circadian rhythms , taste sweet

Diabetes October 2008, Vol.57, 2661-2665. doi:https://doi.org/10.2337/db07-1103

Immunology and Transplantation

Simultaneous Islet and Kidney Transplantation in Seven Patients With Type 1 Diabetes and End-Stage Renal Disease Using a Glucocorticoid-Free Immunosuppressive Regimen With Alemtuzumab Induction

Jianming Tan; Shunliang Yang; Jinquan Cai; Junqi Guo; Lianghu Huang; Zhixian Wu; Jin Chen; Lianming Liao

Abstracts

View articletitled, Simultaneous Islet and Kidney Transplantation in Seven Patients With Type 1 Diabetes and End-Stage Renal Disease Using a Glucocorticoid-Free Immunosuppressive Regimen With Alemtuzumab Induction

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Topics: alemtuzumab , diabetes mellitus, type 1 , glucocorticoids , immunosuppressive agents , insulin

Diabetes October 2008, Vol.57, 2666-2671. doi:https://doi.org/10.2337/db08-0358

CD28/CD154 Blockade Prevents Autoimmune Diabetes by Inducing Nondeletional Tolerance After Effector T-Cell Inhibition and Regulatory T-Cell Expansion

Mark R. Rigby; Alison M. Trexler; Thomas C. Pearson; Christian P. Larsen

Abstracts

View articletitled, CD28/CD154 Blockade Prevents Autoimmune Diabetes by Inducing Nondeletional Tolerance After Effector T-Cell Inhibition and Regulatory T-Cell Expansion

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Topics: antigens , cd28 antigens , cd40 ligand , lymphocyte costimulation , mice

Diabetes October 2008, Vol.57, 2672-2683. doi:https://doi.org/10.2337/db07-1712

Transforming Growth Factor-β Suppresses the Activation of CD8⁺ T-Cells When Naïve but Promotes Their Survival and Function Once Antigen Experienced : A Two-Faced Impact on Autoimmunity

Christophe M. Filippi; Amy E. Juedes; Janine E. Oldham; Ellie Ling; Lisa Togher; Yufeng Peng; Richard A. Flavell; Matthias G. von Herrath

Abstracts

View articletitled, Transforming Growth Factor-β Suppresses the Activation of CD8+ T-Cells When Naïve but Promotes Their Survival and Function Once Antigen Experienced : A Two-Faced Impact on Autoimmunity

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Topics: antigens , mice , t-lymphocytes , memory , autoimmunity

Diabetes October 2008, Vol.57, 2684-2692. doi:https://doi.org/10.2337/db08-0609

A Common Nonsynonymous Single Nucleotide Polymorphism in the SLC30A8 Gene Determines ZnT8 Autoantibody Specificity in Type 1 Diabetes

Janet M. Wenzlau; Yu Liu; Liping Yu; Ong Moua; Kimberly T. Fowler; Sampathkumar Rangasamy; Jay Walters; George S. Eisenbarth; Howard W. Davidson; John C. Hutton

Abstracts

View articletitled, A Common Nonsynonymous Single Nucleotide Polymorphism in the SLC30A8 Gene Determines ZnT8 Autoantibody Specificity in Type 1 Diabetes

Supplementary data

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Topics: autoantibodies , diabetes mellitus, type 1 , single nucleotide polymorphism , slc30a8 gene , antigens

Diabetes October 2008, Vol.57, 2693-2697. doi:https://doi.org/10.2337/db08-0522

Islet Studies

Decreased Fetal Size Is Associated With β-Cell Hyperfunction in Early Life and Failure With Age

Manu V. Chakravarthy; Yimin Zhu; Mitchell B. Wice; Trey Coleman; Kirk L. Pappan; Connie A. Marshall; Michael L. McDaniel; Clay F. Semenkovich

Abstracts

View articletitled, Decreased Fetal Size Is Associated With β-Cell Hyperfunction in Early Life and Failure With Age

Supplementary data

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Topics: fetus , insulin , mice , pancreas

Diabetes October 2008, Vol.57, 2698-2707. doi:https://doi.org/10.2337/db08-0404

miR-375 Targets 3′-Phosphoinositide–Dependent Protein Kinase-1 and Regulates Glucose-Induced Biological Responses in Pancreatic β-Cells

Abdelfattah El Ouaamari; Nadine Baroukh; Geert A. Martens; Patricia Lebrun; Daniel Pipeleers; Emmanuel van Obberghen

Abstracts

View articletitled, miR-375 Targets 3′-Phosphoinositide–Dependent Protein Kinase-1 and Regulates Glucose-Induced Biological Responses in Pancreatic β-Cells

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Topics: glucose , insulin

Diabetes October 2008, Vol.57, 2708-2717. doi:https://doi.org/10.2337/db07-1614

Postnatal Expansion of the Pancreatic β-Cell Mass Is Dependent on Survivin

Yuying Jiang; Wataru Nishimura; Deborah Devor-Henneman; Donna Kusewitt; Haijuan Wang; Michael P. Holloway; Takehiko Dohi; Edmond Sabo; Michael L. Robinson; Dario C. Altieri; Arun Sharma; Rachel A. Altura

Abstracts

View articletitled, Postnatal Expansion of the Pancreatic β-Cell Mass Is Dependent on Survivin

Supplementary data

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Topics: survivin , pancreas , mice

Diabetes October 2008, Vol.57, 2718-2727. doi:https://doi.org/10.2337/db08-0170

Alterations in MicroRNA Expression Contribute to Fatty Acid–Induced Pancreatic β-Cell Dysfunction

Pascal Lovis; Elodie Roggli; D. Ross Laybutt; Sonia Gattesco; Jiang-Yan Yang; Christian Widmann; Amar Abderrahmani; Romano Regazzi

Abstracts

View articletitled, Alterations in MicroRNA Expression Contribute to Fatty Acid–Induced Pancreatic β-Cell Dysfunction

Supplementary data

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Topics: micrornas , palmitates , rna , pancreas , luciferases

Diabetes October 2008, Vol.57, 2728-2736. doi:https://doi.org/10.2337/db07-1252

Spontaneous Diabetes in Hemizygous Human Amylin Transgenic Mice That Developed Neither Islet Amyloid nor Peripheral Insulin Resistance

Winifred P.S. Wong; David W. Scott; Chia-Lin Chuang; Shaoping Zhang; Hong Liu; Athena Ferreira; Etuate L. Saafi; Yee Soon Choong; Garth J.S. Cooper

Abstracts

View articletitled, Spontaneous Diabetes in Hemizygous Human Amylin Transgenic Mice That Developed Neither Islet Amyloid nor Peripheral Insulin Resistance

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Topics: amyloid , animals, transgenic , iapp gene , insulin , mice

Diabetes October 2008, Vol.57, 2737-2744. doi:https://doi.org/10.2337/db06-1755

Hepatocyte Growth Factor Enhances Engraftment and Function of Nonhuman Primate Islets

Nathalie M. Fiaschi-Taesch; Dora M. Berman; Brian M. Sicari; Karen K. Takane; Adolfo Garcia-Ocaña; Camillo Ricordi; Norma S. Kenyon; Andrew F. Stewart

Abstracts

View articletitled, Hepatocyte Growth Factor Enhances Engraftment and Function of Nonhuman Primate Islets

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Topics: adenoviruses , insulin , islets of langerhans transplantation , mice , transplantation

Diabetes October 2008, Vol.57, 2745-2754. doi:https://doi.org/10.2337/db07-1085

Mouse Pancreatic Endocrine Cell Transcriptome Defined in the Embryonic Ngn3-Null Mouse

Kirstine Juhl; Suparna A. Sarkar; Randall Wong; Jan Jensen; John C. Hutton

Abstracts

View articletitled, Mouse Pancreatic Endocrine Cell Transcriptome Defined in the Embryonic Ngn3-Null Mouse

Supplementary data

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Topics: embryo , endocrine cells , genes , glucagon , insulin

Diabetes October 2008, Vol.57, 2755-2761. doi:https://doi.org/10.2337/db07-1126

Pathophysiology

Plasma Fetuin-A Levels and the Risk of Type 2 Diabetes

Norbert Stefan; Andreas Fritsche; Cornelia Weikert; Heiner Boeing; Hans-Georg Joost; Hans-Ulrich Häring; Matthias B. Schulze

Abstracts

View articletitled, Plasma Fetuin-A Levels and the Risk of Type 2 Diabetes

Supplementary data

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Topics: alpha-fetoproteins , diabetes mellitus, type 2 , plasma , glucose , triglycerides

Diabetes October 2008, Vol.57, 2762-2767. doi:https://doi.org/10.2337/db08-0538

Distinct Monocyte Gene-Expression Profiles in Autoimmune Diabetes

Roos C. Padmos; Nanette C. Schloot; Huriya Beyan; Cindy Ruwhof; Frank J.T. Staal; Dick de Ridder; Henk-Jan Aanstoot; Wai Kwan Lam-Tse; Harm de Wit; Christian de Herder; Roos C. Drexhage; Barbara Menart; R. David Leslie; Hemmo A. Drexhage; the LADA Consortium

Abstracts

View articletitled, Distinct Monocyte Gene-Expression Profiles in Autoimmune Diabetes

Supplementary data

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Topics: anterior descending branch of left coronary artery , autoimmunity , diabetes mellitus, type 1 , gene expression , genes

Diabetes October 2008, Vol.57, 2768-2773. doi:https://doi.org/10.2337/db08-0496

Complications

Neuronatin: A New Inflammation Gene Expressed on the Aortic Endothelium of Diabetic Mice

Nino Mzhavia; Shuiqing Yu; Shota Ikeda; Tehua T. Chu; Ira Goldberg; Hayes M. Dansky

Abstracts

View articletitled, Neuronatin: A New Inflammation Gene Expressed on the Aortic Endothelium of Diabetic Mice

Supplementary data

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Topics: aorta , endothelial cells , mice , genes , vascular cell adhesion molecule-1

Diabetes October 2008, Vol.57, 2774-2783. doi:https://doi.org/10.2337/db07-1746

Potent Inhibition of Cicatricial Contraction in Proliferative Vitreoretinal Diseases by Statins

Shuhei Kawahara; Yasuaki Hata; Takeshi Kita; Ryoichi Arita; Muneki Miura; Shintaro Nakao; Yasutaka Mochizuki; Hiroshi Enaida; Tadahisa Kagimoto; Yoshinobu Goto; Ali Hafezi-Moghadam; Tatsuro Ishibashi

Abstracts

View articletitled, Potent Inhibition of Cicatricial Contraction in Proliferative Vitreoretinal Diseases by Statins

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Topics: collagen , gel , simvastatin , vitreous body , statins

Diabetes October 2008, Vol.57, 2784-2793. doi:https://doi.org/10.2337/db08-0302

Correction of HDL Dysfunction in Individuals With Diabetes and the Haptoglobin 2-2 Genotype

Rabea Asleh; Shany Blum; Shiri Kalet-Litman; Jonia Alshiek; Rachel Miller-Lotan; Roy Asaf; Wasseem Rock; Michael Aviram; Uzi Milman; Chen Shapira; Zaid Abassi; Andrew P. Levy

Abstracts

View articletitled, Correction of HDL Dysfunction in Individuals With Diabetes and the Haptoglobin 2-2 Genotype

Supplementary data

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Topics: high density lipoproteins

Diabetes October 2008, Vol.57, 2794-2800. doi:https://doi.org/10.2337/db08-0450

Sulfasalazine Blocks the Development of Tactile Allodynia in Diabetic Rats

Liliana N. Berti-Mattera; Timothy S. Kern; Ruth E. Siegel; Ina Nemet; Rochanda Mitchell

Abstracts

View articletitled, Sulfasalazine Blocks the Development of Tactile Allodynia in Diabetic Rats

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Topics: allodynia , rats , sulfasalazine , sciatic nerve

Diabetes October 2008, Vol.57, 2801-2808. doi:https://doi.org/10.2337/db07-1274

Activation of NF-E2–Related Factor-2 Reverses Biochemical Dysfunction of Endothelial Cells Induced by Hyperglycemia Linked to Vascular Disease

Mingzhan Xue; Qingwen Qian; Antonysunil Adaikalakoteswari; Naila Rabbani; Roya Babaei-Jadidi; Paul J. Thornalley

Abstracts

View articletitled, Activation of NF-E2–Related Factor-2 Reverses Biochemical Dysfunction of Endothelial Cells Induced by Hyperglycemia Linked to Vascular Disease

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Topics: endothelial cells , hyperglycemia , sulforaphane , transketolase , gene expression

Diabetes October 2008, Vol.57, 2809-2817. doi:https://doi.org/10.2337/db06-1003

Impaired Collateral Recruitment and Outward Remodeling in Experimental Diabetes

Jolanda M. van Golde; Matthijs S. Ruiter; Nicolaas C. Schaper; Stefan Vöö; Johannes Waltenberger; Walter H. Backes; Mark J. Post; Maya S. Huijberts

Abstracts

View articletitled, Impaired Collateral Recruitment and Outward Remodeling in Experimental Diabetes

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Topics: angiogram , diabetes mellitus, experimental , ligation , monocytes , oryctolagus cuniculus

Diabetes October 2008, Vol.57, 2818-2823. doi:https://doi.org/10.2337/db08-0229

Inducible Overexpression of sFlt-1 in Podocytes Ameliorates Glomerulopathy in Diabetic Mice

Ching-Hsin Ku; Kathryn E. White; Alessandra Dei Cas; Anthea Hayward; Zoe Webster; Rudy Bilous; Sally Marshall; Giancarlo Viberti; Luigi Gnudi

Abstracts

View articletitled, Inducible Overexpression of sFlt-1 in Podocytes Ameliorates Glomerulopathy in Diabetic Mice

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Topics: mice , podocytes , soluble fms-like tyrosine kinase 1 , vascular endothelial growth factor a , kidney glomerulus

Diabetes October 2008, Vol.57, 2824-2833. doi:https://doi.org/10.2337/db08-0647

Genetics

Common Variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE Genes Are Associated With Type 2 Diabetes and Impaired Fasting Glucose in a Chinese Han Population

Ying Wu; Huaixing Li; Ruth J.F. Loos; Zhijie Yu; Xingwang Ye; Lihua Chen; An Pan; Frank B. Hu; Xu Lin

Abstracts

View articletitled, Common Variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE Genes Are Associated With Type 2 Diabetes and Impaired Fasting Glucose in a Chinese Han Population

Supplementary data

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Topics: diabetes mellitus, type 2 , genes, p16 , impaired fasting glucose , slc30a8 gene , single nucleotide polymorphism

Diabetes October 2008, Vol.57, 2834-2842. doi:https://doi.org/10.2337/db08-0047

G/T Substitution in Intron 1 of the UNC13B Gene Is Associated With Increased Risk of Nephropathy in Patients With Type 1 Diabetes

Abstracts

View articletitled, G/T Substitution in Intron 1 of the UNC13B Gene Is Associated With Increased Risk of Nephropathy in Patients With Type 1 Diabetes

Supplementary data

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Topics: diabetes mellitus, type 1 , diabetic nephropathy , genes , genotype determination , introns

Diabetes October 2008, Vol.57, 2843-2850. doi:https://doi.org/10.2337/db08-0073

FTO Variants Are Associated With Obesity in the Chinese and Malay Populations in Singapore

Jonathan T. Tan; Rajkumar Dorajoo; Mark Seielstad; Xue Ling Sim; Rick Twee-Hee Ong; Kee Seng Chia; Tien Yin Wong; Seang Mei Saw; Suok Kai Chew; Tin Aung; E-Shyong Tai

Abstracts

View articletitled, FTO Variants Are Associated With Obesity in the Chinese and Malay Populations in Singapore

Supplementary data

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Topics: body mass index procedure , diabetes mellitus, type 2 , fto gene , obesity , singapore

Diabetes October 2008, Vol.57, 2851-2857. doi:https://doi.org/10.2337/db08-0214

A Human Type 1 Diabetes Susceptibility Locus Maps to Chromosome 21q22.3

Patrick Concannon; Suna Onengut-Gumuscu; John A. Todd; Deborah J. Smyth; Flemming Pociot; Regine Bergholdt; Beena Akolkar; Henry A. Erlich; Joan E. Hilner; Cécile Julier; Grant Morahan; Jørn Nerup; Concepcion R. Nierras; Wei-Min Chen; Stephen S. Rich; the Type 1 Diabetes Genetics Consortium

Abstracts

View articletitled, A Human Type 1 Diabetes Susceptibility Locus Maps to Chromosome 21q22.3

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Topics: diabetes mellitus, type 1 , genotype determination , chromosomes , single nucleotide polymorphism , genome

Diabetes October 2008, Vol.57, 2858-2861. doi:https://doi.org/10.2337/db08-0753

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