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Issues
Perspectives in Diabetes
Viral Trigger for Type 1 Diabetes: Pros and Cons
Diabetes November 2008, Vol.57, 2863-2871. doi:https://doi.org/10.2337/db07-1023
β-Cell Mass and Type 1 Diabetes: Going, Going, Gone?
Diabetes November 2008, Vol.57, 2883-2888. doi:https://doi.org/10.2337/db07-1817
Learning From Molecular Genetics: Novel Insights Arising From the Definition of Genes for Monogenic and Type 2 Diabetes
Diabetes November 2008, Vol.57, 2889-2898. doi:https://doi.org/10.2337/db08-0343
Islets in Type 2 Diabetes: In Honor of Dr. Robert C. Turner
Diabetes November 2008, Vol.57, 2899-2904. doi:https://doi.org/10.2337/db07-1842
Human Obesity: A Heritable Neurobehavioral Disorder That Is Highly Sensitive to Environmental Conditions
Diabetes November 2008, Vol.57, 2905-2910. doi:https://doi.org/10.2337/db08-0210
Commentaries
Genes Associated With Risk of Type 2 Diabetes Identified by a Candidate-Wide Association Scan: As a Trickle Becomes a Flood
Diabetes November 2008, Vol.57, 2915-2917. doi:https://doi.org/10.2337/db08-0941
An Appreciation of Robert Turner
Diabetes November 2008, Vol.57, 2918-2921. doi:https://doi.org/10.2337/db07-1644
Big Mac Attack: Does It Play a Direct Role for Monocytes/Macrophages in Type 1 Diabetes?
Diabetes November 2008, Vol.57, 2922-2923. doi:https://doi.org/10.2337/db08-1007
Metabolism
Type 1 Diabetic Akita Mouse Hearts Are Insulin Sensitive but Manifest Structurally Abnormal Mitochondria That Remain Coupled Despite Increased Uncoupling Protein 3
Heiko Bugger; Sihem Boudina; Xiao Xuan Hu; Joseph Tuinei; Vlad G. Zaha; Heather A. Theobald; Ui Jeong Yun; Alfred P. McQueen; Benjamin Wayment; Sheldon E. Litwin; E. Dale Abel
Diabetes November 2008, Vol.57, 2924-2932. doi:https://doi.org/10.2337/db08-0079
Endurance Exercise as a Countermeasure for Aging
Ian R. Lanza; Daniel K. Short; Kevin R. Short; Sreekumar Raghavakaimal; Rita Basu; Michael J. Joyner; Joseph P. McConnell; K. Sreekumaran Nair
Diabetes November 2008, Vol.57, 2933-2942. doi:https://doi.org/10.2337/db08-0349
Lower Intrinsic ADP-Stimulated Mitochondrial Respiration Underlies In Vivo Mitochondrial Dysfunction in Muscle of Male Type 2 Diabetic Patients
Esther Phielix; Vera B. Schrauwen-Hinderling; Marco Mensink; Ellen Lenaers; Ruth Meex; Joris Hoeks; Marianne Eline Kooi; Esther Moonen-Kornips; Jean-Pierre Sels; Matthijs K.C. Hesselink; Patrick Schrauwen
Diabetes November 2008, Vol.57, 2943-2949. doi:https://doi.org/10.2337/db08-0391
Lymphocytes of Type 2 Diabetic Women Carry a High Load of Stable Chromosomal Aberrations : A Novel Risk Factor for Disease-Related Early Death
Bernhard O. Boehm; Peter Möller; Josef Högel; Bernhard R. Winkelmann; Wilfried Renner; Silke Rosinger; Ursula Seelhorst; Britta Wellnitz; Winfried März; Julia Melzner; Silke Brüderlein
Diabetes November 2008, Vol.57, 2950-2957. doi:https://doi.org/10.2337/db08-0274
Ablation of AMP-Activated Protein Kinase α2 Activity Exacerbates Insulin Resistance Induced by High-Fat Feeding of Mice
Nobuharu Fujii; Richard C. Ho; Yasuko Manabe; Niels Jessen; Taro Toyoda; William L. Holland; Scott A. Summers; Michael F. Hirshman; Laurie J. Goodyear
Diabetes November 2008, Vol.57, 2958-2966. doi:https://doi.org/10.2337/db07-1187
Signal Transduction
Forkhead Transcription Factors (FoxOs) Promote Apoptosis of Insulin-Resistant Macrophages During Cholesterol-Induced Endoplasmic Reticulum Stress
Takafumi Senokuchi; Chien-Ping Liang; Tracie A. Seimon; Seongah Han; Michihiro Matsumoto; Alexander S. Banks; Ji-Hye Paik; Ronald A. DePinho; Domenico Accili; Ira Tabas; Alan R. Tall
Diabetes November 2008, Vol.57, 2967-2976. doi:https://doi.org/10.2337/db08-0520
Obesity Studies
Peripheral, but Not Central, CB1 Antagonism Provides Food Intake–Independent Metabolic Benefits in Diet-Induced Obese Rats
Ruben Nogueiras; Christelle Veyrat-Durebex; Paula M. Suchanek; Marcella Klein; Johannes Tschöp; Charles Caldwell; Stephen C. Woods; Gabor Wittmann; Masahiko Watanabe; Zsolt Liposits; Csaba Fekete; Ofer Reizes; Francoise Rohner-Jeanrenaud; Matthias H. Tschöp
Diabetes November 2008, Vol.57, 2977-2991. doi:https://doi.org/10.2337/db08-0161
Oxidative Stress Regulates Adipocyte Apolipoprotein E and Suppresses Its Expression in Obesity
Diabetes November 2008, Vol.57, 2992-2998. doi:https://doi.org/10.2337/db08-0592
Lack of FFAR1/GPR40 Does Not Protect Mice From High-Fat Diet–Induced Metabolic Disease
Hong Lan; Lizbeth M. Hoos; Li Liu; Glen Tetzloff; Weiwen Hu; Susan J. Abbondanzo; Galya Vassileva; Eric L. Gustafson; Joseph A. Hedrick; Harry R. Davis
Diabetes November 2008, Vol.57, 2999-3006. doi:https://doi.org/10.2337/db08-0596
Immunology and Transplantation
Targeting CD22 Reprograms B-Cells and Reverses Autoimmune Diabetes
Paolo Fiorina; Andrea Vergani; Shirine Dada; Mollie Jurewicz; Masie Wong; Kenneth Law; Erxi Wu; Ze Tian; Reza Abdi; Indira Guleria; Scott Rodig; Kyri Dunussi-Joannopoulos; Jeffrey Bluestone; Mohamed H. Sayegh
Diabetes November 2008, Vol.57, 3013-3024. doi:https://doi.org/10.2337/db08-0420
Islet Studies
Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling
Mia C. Åkerfeldt; Jennifer Howes; Jeng Yie Chan; Veronica A. Stevens; Nacer Boubenna; Helen M. McGuire; Cecile King; Trevor J. Biden; D. Ross Laybutt
Diabetes November 2008, Vol.57, 3034-3044. doi:https://doi.org/10.2337/db07-1802
Small Interfering RNA–Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture
Lucy Marzban; Alejandra Tomas; Thomas C. Becker; Lawrence Rosenberg; Jose Oberholzer; Paul E. Fraser; Philippe A. Halban; C. Bruce Verchere
Diabetes November 2008, Vol.57, 3045-3055. doi:https://doi.org/10.2337/db08-0485
Lessons From the First Comprehensive Molecular Characterization of Cell Cycle Control in Rodent Insulinoma Cell Lines
Irene Cozar-Castellano; George Harb; Karen Selk; Karen Takane; Rupangi Vasavada; Brian Sicari; Brian Law; Pili Zhang; Donald K. Scott; Nathalie Fiaschi-Taesch; Andrew F. Stewart
Diabetes November 2008, Vol.57, 3056-3068. doi:https://doi.org/10.2337/db08-0393
β-Cell Proliferation, but Not Neogenesis, Following 60% Partial Pancreatectomy Is Impaired in the Absence of FoxM1
Diabetes November 2008, Vol.57, 3069-3077. doi:https://doi.org/10.2337/db08-0878
Pathophysiology
Plasma YKL-40: A BMI-Independent Marker of Type 2 Diabetes
Anders R. Nielsen; Christian Erikstrup; Julia S. Johansen; Christian P. Fischer; Peter Plomgaard; Rikke Krogh-Madsen; Sarah Taudorf; Birgitte Lindegaard; Bente K. Pedersen
Diabetes November 2008, Vol.57, 3078-3082. doi:https://doi.org/10.2337/db08-0182
Complications
Diffusion Tensor Imaging Identifies Deficits in White Matter Microstructure in Subjects With Type 1 Diabetes That Correlate With Reduced Neurocognitive Function
Christopher T. Kodl; Daniel T. Franc; Jyothi P. Rao; Fiona S. Anderson; William Thomas; Bryon A. Mueller; Kelvin O. Lim; Elizabeth R. Seaquist
Diabetes November 2008, Vol.57, 3083-3089. doi:https://doi.org/10.2337/db08-0724
High Glucose Induces Toll-Like Receptor Expression in Human Monocytes: Mechanism of Activation
Diabetes November 2008, Vol.57, 3090-3098. doi:https://doi.org/10.2337/db08-0564
Transplantation of Bone Marrow–Derived Mesenchymal Stem Cells Improves Diabetic Polyneuropathy in Rats
Taiga Shibata; Keiko Naruse; Hideki Kamiya; Mika Kozakae; Masaki Kondo; Yutaka Yasuda; Nobuhisa Nakamura; Kimiko Ota; Takahiro Tosaki; Takashi Matsuki; Eitaro Nakashima; Yoji Hamada; Yutaka Oiso; Jiro Nakamura
Diabetes November 2008, Vol.57, 3099-3107. doi:https://doi.org/10.2337/db08-0031
Association of Organochlorine Pesticides with Peripheral Neuropathy in Patients with Diabetes or Impaired Fasting Glucose
Diabetes November 2008, Vol.57, 3108-3111. doi:https://doi.org/10.2337/db08-0668
Genetics
Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations
Marju Orho-Melander; Olle Melander; Candace Guiducci; Pablo Perez-Martinez; Dolores Corella; Charlotta Roos; Ryan Tewhey; Mark J. Rieder; Jennifer Hall; Goncalo Abecasis; E. Shyong Tai; Cullan Welch; Donna K. Arnett; Valeriya Lyssenko; Eero Lindholm; Richa Saxena; Paul I.W. de Bakker; Noel Burtt; Benjamin F. Voight; Joel N. Hirschhorn; Katherine L. Tucker; Thomas Hedner; Tiinamaija Tuomi; Bo Isomaa; Karl-Fredrik Eriksson; Marja-Riitta Taskinen; Björn Wahlstrand; Thomas E. Hughes; Laurence D. Parnell; Chao-Qiang Lai; Göran Berglund; Leena Peltonen; Erkki Vartiainen; Pekka Jousilahti; Aki S. Havulinna; Veikko Salomaa; Peter Nilsson; Leif Groop; David Altshuler; Jose M. Ordovas; Sekar Kathiresan
Diabetes November 2008, Vol.57, 3112-3121. doi:https://doi.org/10.2337/db08-0516
Predicting Type 2 Diabetes Based on Polymorphisms From Genome-Wide Association Studies : A Population-Based Study
Mandy van Hoek; Abbas Dehghan; Jacqueline C.M. Witteman; Cornelia M. van Duijn; André G. Uitterlinden; Ben A. Oostra; Albert Hofman; Eric J.G. Sijbrands; A. Cecile J.W. Janssens
Diabetes November 2008, Vol.57, 3122-3128. doi:https://doi.org/10.2337/db08-0425
Assessing the Combined Impact of 18 Common Genetic Variants of Modest Effect Sizes on Type 2 Diabetes Risk
Hana Lango; the U.K. Type 2 Diabetes Genetics Consortium; Colin N.A. Palmer; Andrew D. Morris; Eleftheria Zeggini; Andrew T. Hattersley; Mark I. McCarthy; Timothy M. Frayling; Michael N. Weedon
Diabetes November 2008, Vol.57, 3129-3135. doi:https://doi.org/10.2337/db08-0504
Comprehensive Association Study of Type 2 Diabetes and Related Quantitative Traits With 222 Candidate Genes
Kyle J. Gaulton; Cristen J. Willer; Yun Li; Laura J. Scott; Karen N. Conneely; Anne U. Jackson; William L. Duren; Peter S. Chines; Narisu Narisu; Lori L. Bonnycastle; Jingchun Luo; Maurine Tong; Andrew G. Sprau; Elizabeth W. Pugh; Kimberly F. Doheny; Timo T. Valle; Gonçalo R. Abecasis; Jaakko Tuomilehto; Richard N. Bergman; Francis S. Collins; Michael Boehnke; Karen L. Mohlke
Diabetes November 2008, Vol.57, 3136-3144. doi:https://doi.org/10.2337/db07-1731
Fat Mass–and Obesity-Associated (FTO) Gene Variant Is Associated With Obesity: Longitudinal Analyses in Two Cohort Studies and Functional Test
Lu Qi; Kihwa Kang; Cuilin Zhang; Rob M. van Dam; Peter Kraft; David Hunter; Chih-Hao Lee; Frank B. Hu
Diabetes November 2008, Vol.57, 3145-3151. doi:https://doi.org/10.2337/db08-0006
Two Single Nucleotide Polymorphisms Identify the Highest-Risk Diabetes HLA Genotype: Potential for Rapid Screening
Jennifer M. Barker; Taylor M. Triolo; Theresa A. Aly; Erin E. Baschal; Sunanda R. Babu; Adam Kretowski; Marian J. Rewers; George S. Eisenbarth
Diabetes November 2008, Vol.57, 3152-3155. doi:https://doi.org/10.2337/db08-0605
PCLO Variants Are Nominally Associated With Early-Onset Type 2 Diabetes and Insulin Resistance in Pima Indians
Diabetes November 2008, Vol.57, 3156-3160. doi:https://doi.org/10.2337/db07-1800
Population-Specific Risk of Type 2 Diabetes Conferred by HNF4A P2 Promoter Variants: A Lesson for Replication Studies
Inês Barroso; Jian’an Luan; Eleanor Wheeler; Pamela Whittaker; Jon Wasson; Eleftheria Zeggini; Michael N. Weedon; Sarah Hunt; Ranganath Venkatesh; Timothy M. Frayling; Marcos Delgado; Rosalind J. Neuman; Jinghua Zhao; Richard Sherva; Benjamin Glaser; Mark Walker; Graham Hitman; Mark I. McCarthy; Andrew T. Hattersley; M. Alan Permutt; Nicholas J. Wareham; Panagiotis Deloukas
Diabetes November 2008, Vol.57, 3161-3165. doi:https://doi.org/10.2337/db08-0719