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Issues
Perspectives in Diabetes
Viral Trigger for Type 1 Diabetes: Pros and Cons
Topics:
autoimmunity
,
diabetes mellitus, type 1
,
infections
,
virus diseases
,
viruses
Diabetes November 2008, Vol.57, 2863-2871. doi:https://doi.org/10.2337/db07-1023
Primer: Immunity and Autoimmunity
Topics:
antigens
,
autoimmunity
,
diabetes mellitus, type 1
,
t-lymphocytes
,
peptides
Diabetes November 2008, Vol.57, 2872-2882. doi:https://doi.org/10.2337/db07-1691
β-Cell Mass and Type 1 Diabetes: Going, Going, Gone?
Topics:
diabetes mellitus, type 1
,
hyperglycemia
,
inflammation
,
insulin
,
mice
Diabetes November 2008, Vol.57, 2883-2888. doi:https://doi.org/10.2337/db07-1817
Learning From Molecular Genetics: Novel Insights Arising From the Definition of Genes for Monogenic and Type 2 Diabetes
Topics:
diabetes mellitus, type 2
,
genes
,
genetics
Diabetes November 2008, Vol.57, 2889-2898. doi:https://doi.org/10.2337/db08-0343
Islets in Type 2 Diabetes: In Honor of Dr. Robert C. Turner
Topics:
diabetes mellitus, type 2
,
pancreas
,
obesity
,
iapp gene
Diabetes November 2008, Vol.57, 2899-2904. doi:https://doi.org/10.2337/db07-1842
Human Obesity: A Heritable Neurobehavioral Disorder That Is Highly Sensitive to Environmental Conditions
Topics:
obesity
Diabetes November 2008, Vol.57, 2905-2910. doi:https://doi.org/10.2337/db08-0210
Commentaries
Public Health Genomics Approach to Type 2 Diabetes
Diabetes November 2008, Vol.57, 2911-2914. doi:https://doi.org/10.2337/db08-1045
Genes Associated With Risk of Type 2 Diabetes Identified by a Candidate-Wide Association Scan: As a Trickle Becomes a Flood
Topics:
diabetes mellitus, type 2
,
genes
,
floods
Diabetes November 2008, Vol.57, 2915-2917. doi:https://doi.org/10.2337/db08-0941
An Appreciation of Robert Turner
Topics:
diabetes mellitus, type 2
,
insulin
,
uk prospective diabetes study
,
insulin secretion
,
physiology
Diabetes November 2008, Vol.57, 2918-2921. doi:https://doi.org/10.2337/db07-1644
Big Mac Attack: Does It Play a Direct Role for Monocytes/Macrophages in Type 1 Diabetes?
Diabetes November 2008, Vol.57, 2922-2923. doi:https://doi.org/10.2337/db08-1007
Metabolism
Type 1 Diabetic Akita Mouse Hearts Are Insulin Sensitive but Manifest Structurally Abnormal Mitochondria That Remain Coupled Despite Increased Uncoupling Protein 3
Heiko Bugger; Sihem Boudina; Xiao Xuan Hu; Joseph Tuinei; Vlad G. Zaha; Heather A. Theobald; Ui Jeong Yun; Alfred P. McQueen; Benjamin Wayment; Sheldon E. Litwin; E. Dale Abel
Topics:
heart
,
insulin
,
mice
,
mitochondria
,
uncoupling protein 3
Diabetes November 2008, Vol.57, 2924-2932. doi:https://doi.org/10.2337/db08-0079
Endurance Exercise as a Countermeasure for Aging
Ian R. Lanza; Daniel K. Short; Kevin R. Short; Sreekumar Raghavakaimal; Rita Basu; Michael J. Joyner; Joseph P. McConnell; K. Sreekumaran Nair
Topics:
aging
,
dna, mitochondrial
,
insulin sensitivity
,
lack of exercise
,
mitochondria
Diabetes November 2008, Vol.57, 2933-2942. doi:https://doi.org/10.2337/db08-0349
Lower Intrinsic ADP-Stimulated Mitochondrial Respiration Underlies In Vivo Mitochondrial Dysfunction in Muscle of Male Type 2 Diabetic Patients
Esther Phielix; Vera B. Schrauwen-Hinderling; Marco Mensink; Ellen Lenaers; Ruth Meex; Joris Hoeks; Marianne Eline Kooi; Esther Moonen-Kornips; Jean-Pierre Sels; Matthijs K.C. Hesselink; Patrick Schrauwen
Topics:
mitochondria
,
insulin
,
respiration
Diabetes November 2008, Vol.57, 2943-2949. doi:https://doi.org/10.2337/db08-0391
Lymphocytes of Type 2 Diabetic Women Carry a High Load of Stable Chromosomal Aberrations : A Novel Risk Factor for Disease-Related Early Death
Bernhard O. Boehm; Peter Möller; Josef Högel; Bernhard R. Winkelmann; Wilfried Renner; Silke Rosinger; Ursula Seelhorst; Britta Wellnitz; Winfried März; Julia Melzner; Silke Brüderlein
Topics:
chromosome abnormality
,
chromosomes
,
diabetes in women
,
diabetes mellitus, type 2
,
lymphocytes
Diabetes November 2008, Vol.57, 2950-2957. doi:https://doi.org/10.2337/db08-0274
Ablation of AMP-Activated Protein Kinase α2 Activity Exacerbates Insulin Resistance Induced by High-Fat Feeding of Mice
Nobuharu Fujii; Richard C. Ho; Yasuko Manabe; Niels Jessen; Taro Toyoda; William L. Holland; Scott A. Summers; Michael F. Hirshman; Laurie J. Goodyear
Topics:
ablation
,
ampk
,
blood glucose
,
diet
,
diet, high-fat
Diabetes November 2008, Vol.57, 2958-2966. doi:https://doi.org/10.2337/db07-1187
Signal Transduction
Forkhead Transcription Factors (FoxOs) Promote Apoptosis of Insulin-Resistant Macrophages During Cholesterol-Induced Endoplasmic Reticulum Stress
Takafumi Senokuchi; Chien-Ping Liang; Tracie A. Seimon; Seongah Han; Michihiro Matsumoto; Alexander S. Banks; Ji-Hye Paik; Ronald A. DePinho; Domenico Accili; Ira Tabas; Alan R. Tall
Topics:
apoptosis
,
forkhead box protein o1
,
insulin receptor
,
macrophages
,
stress
Diabetes November 2008, Vol.57, 2967-2976. doi:https://doi.org/10.2337/db08-0520
Obesity Studies
Peripheral, but Not Central, CB1 Antagonism Provides Food Intake–Independent Metabolic Benefits in Diet-Induced Obese Rats
Ruben Nogueiras; Christelle Veyrat-Durebex; Paula M. Suchanek; Marcella Klein; Johannes Tschöp; Charles Caldwell; Stephen C. Woods; Gabor Wittmann; Masahiko Watanabe; Zsolt Liposits; Csaba Fekete; Ofer Reizes; Francoise Rohner-Jeanrenaud; Matthias H. Tschöp
Topics:
antagonists
,
eating
,
obesity
,
rats
,
infusion procedures
Diabetes November 2008, Vol.57, 2977-2991. doi:https://doi.org/10.2337/db08-0161
Oxidative Stress Regulates Adipocyte Apolipoprotein E and Suppresses Its Expression in Obesity
Topics:
adipocytes
,
apolipoprotein e
,
obesity
,
rna, messenger
,
oxidative stress
Diabetes November 2008, Vol.57, 2992-2998. doi:https://doi.org/10.2337/db08-0592
Lack of FFAR1/GPR40 Does Not Protect Mice From High-Fat Diet–Induced Metabolic Disease
Hong Lan; Lizbeth M. Hoos; Li Liu; Glen Tetzloff; Weiwen Hu; Susan J. Abbondanzo; Galya Vassileva; Eric L. Gustafson; Joseph A. Hedrick; Harry R. Davis
Topics:
diet, high-fat
,
insulin
,
mice
,
fatty acids
,
metabolic diseases
Diabetes November 2008, Vol.57, 2999-3006. doi:https://doi.org/10.2337/db08-0596
Persistence of Pre-Diabetes in Overweight and Obese Hispanic Children : Association With Progressive Insulin Resistance, Poor β-Cell Function, and Increasing Visceral Fat
Topics:
child
,
insulin resistance
,
obesity
,
overweight
,
prediabetes
Diabetes November 2008, Vol.57, 3007-3012. doi:https://doi.org/10.2337/db08-0445
Immunology and Transplantation
Targeting CD22 Reprograms B-Cells and Reverses Autoimmune Diabetes
Paolo Fiorina; Andrea Vergani; Shirine Dada; Mollie Jurewicz; Masie Wong; Kenneth Law; Erxi Wu; Ze Tian; Reza Abdi; Indira Guleria; Scott Rodig; Kyri Dunussi-Joannopoulos; Jeffrey Bluestone; Mohamed H. Sayegh
Topics:
b-lymphocytes
,
hyperglycemic agents
,
mice, inbred nod
,
monoclonal antibodies
,
t-lymphocytes
Diabetes November 2008, Vol.57, 3013-3024. doi:https://doi.org/10.2337/db08-0420
Increased Expression of CCL2 in Insulin-Producing Cells of Transgenic Mice Promotes Mobilization of Myeloid Cells From the Bone Marrow, Marked Insulitis, and Diabetes
Topics:
bone marrow
,
mice
,
monocyte chemoattractant protein-1
,
monocytes
,
insulin
Diabetes November 2008, Vol.57, 3025-3033. doi:https://doi.org/10.2337/db08-0625
Islet Studies
Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling
Mia C. Åkerfeldt; Jennifer Howes; Jeng Yie Chan; Veronica A. Stevens; Nacer Boubenna; Helen M. McGuire; Cecile King; Trevor J. Biden; D. Ross Laybutt
Topics:
cytokine
,
palmitates
,
stress
,
cell death
,
cyclophosphamide, doxorubicin, prednisone, and vincristine
Diabetes November 2008, Vol.57, 3034-3044. doi:https://doi.org/10.2337/db07-1802
Small Interfering RNA–Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture
Lucy Marzban; Alejandra Tomas; Thomas C. Becker; Lawrence Rosenberg; Jose Oberholzer; Paul E. Fraser; Philippe A. Halban; C. Bruce Verchere
Topics:
adenoviruses
,
amyloid
,
rna, small interfering
,
psychological suppression
,
iapp gene
Diabetes November 2008, Vol.57, 3045-3055. doi:https://doi.org/10.2337/db08-0485
Lessons From the First Comprehensive Molecular Characterization of Cell Cycle Control in Rodent Insulinoma Cell Lines
Irene Cozar-Castellano; George Harb; Karen Selk; Karen Takane; Rupangi Vasavada; Brian Sicari; Brian Law; Pili Zhang; Donald K. Scott; Nathalie Fiaschi-Taesch; Andrew F. Stewart
Topics:
cell cycle
,
cell lines
,
glucose
,
insulinoma
,
rodentia
Diabetes November 2008, Vol.57, 3056-3068. doi:https://doi.org/10.2337/db08-0393
β-Cell Proliferation, but Not Neogenesis, Following 60% Partial Pancreatectomy Is Impaired in the Absence of FoxM1
Topics:
forkhead box protein m1
,
mice
,
prevention
Diabetes November 2008, Vol.57, 3069-3077. doi:https://doi.org/10.2337/db08-0878
Pathophysiology
Plasma YKL-40: A BMI-Independent Marker of Type 2 Diabetes
Anders R. Nielsen; Christian Erikstrup; Julia S. Johansen; Christian P. Fischer; Peter Plomgaard; Rikke Krogh-Madsen; Sarah Taudorf; Birgitte Lindegaard; Bente K. Pedersen
Topics:
adipose tissue
,
diabetes mellitus, type 2
,
inflammation
,
obesity
,
plasma
Diabetes November 2008, Vol.57, 3078-3082. doi:https://doi.org/10.2337/db08-0182
Complications
Diffusion Tensor Imaging Identifies Deficits in White Matter Microstructure in Subjects With Type 1 Diabetes That Correlate With Reduced Neurocognitive Function
Christopher T. Kodl; Daniel T. Franc; Jyothi P. Rao; Fiona S. Anderson; William Thomas; Bryon A. Mueller; Kelvin O. Lim; Elizabeth R. Seaquist
Topics:
anisotropy
,
diabetes mellitus, type 1
,
diffusion tensor imaging
,
magnetic resonance imaging
,
neurocognitive testing
Diabetes November 2008, Vol.57, 3083-3089. doi:https://doi.org/10.2337/db08-0724
High Glucose Induces Toll-Like Receptor Expression in Human Monocytes: Mechanism of Activation
Topics:
glucose
,
toll-like receptor 2
,
toll-like receptor 4
Diabetes November 2008, Vol.57, 3090-3098. doi:https://doi.org/10.2337/db08-0564
Transplantation of Bone Marrow–Derived Mesenchymal Stem Cells Improves Diabetic Polyneuropathy in Rats
Taiga Shibata; Keiko Naruse; Hideki Kamiya; Mika Kozakae; Masaki Kondo; Yutaka Yasuda; Nobuhisa Nakamura; Kimiko Ota; Takahiro Tosaki; Takashi Matsuki; Eitaro Nakashima; Yoji Hamada; Yutaka Oiso; Jiro Nakamura
Topics:
fibroblast growth factor 2
,
muscle fibers
,
rats
,
saline solutions
,
streptozocin
Diabetes November 2008, Vol.57, 3099-3107. doi:https://doi.org/10.2337/db08-0031
Association of Organochlorine Pesticides with Peripheral Neuropathy in Patients with Diabetes or Impaired Fasting Glucose
Topics:
impaired fasting glucose
,
organochlorine insecticide
,
peripheral neuropathy
,
poor glycemic control
Diabetes November 2008, Vol.57, 3108-3111. doi:https://doi.org/10.2337/db08-0668
Genetics
Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations
Marju Orho-Melander; Olle Melander; Candace Guiducci; Pablo Perez-Martinez; Dolores Corella; Charlotta Roos; Ryan Tewhey; Mark J. Rieder; Jennifer Hall; Goncalo Abecasis; E. Shyong Tai; Cullan Welch; Donna K. Arnett; Valeriya Lyssenko; Eero Lindholm; Richa Saxena; Paul I.W. de Bakker; Noel Burtt; Benjamin F. Voight; Joel N. Hirschhorn; Katherine L. Tucker; Thomas Hedner; Tiinamaija Tuomi; Bo Isomaa; Karl-Fredrik Eriksson; Marja-Riitta Taskinen; Björn Wahlstrand; Thomas E. Hughes; Laurence D. Parnell; Chao-Qiang Lai; Göran Berglund; Leena Peltonen; Erkki Vartiainen; Pekka Jousilahti; Aki S. Havulinna; Veikko Salomaa; Peter Nilsson; Leif Groop; David Altshuler; Jose M. Ordovas; Sekar Kathiresan
Topics:
triglycerides
,
glucose
,
genotype
,
fasting blood glucose measurement
,
c-reactive protein
Diabetes November 2008, Vol.57, 3112-3121. doi:https://doi.org/10.2337/db08-0516
Predicting Type 2 Diabetes Based on Polymorphisms From Genome-Wide Association Studies : A Population-Based Study
Mandy van Hoek; Abbas Dehghan; Jacqueline C.M. Witteman; Cornelia M. van Duijn; André G. Uitterlinden; Ben A. Oostra; Albert Hofman; Eric J.G. Sijbrands; A. Cecile J.W. Janssens
Diabetes November 2008, Vol.57, 3122-3128. doi:https://doi.org/10.2337/db08-0425
Assessing the Combined Impact of 18 Common Genetic Variants of Modest Effect Sizes on Type 2 Diabetes Risk
Hana Lango; the U.K. Type 2 Diabetes Genetics Consortium; Colin N.A. Palmer; Andrew D. Morris; Eleftheria Zeggini; Andrew T. Hattersley; Mark I. McCarthy; Timothy M. Frayling; Michael N. Weedon
Topics:
diabetes mellitus, type 2
,
genetics
,
body mass index procedure
,
single nucleotide polymorphism
Diabetes November 2008, Vol.57, 3129-3135. doi:https://doi.org/10.2337/db08-0504
Comprehensive Association Study of Type 2 Diabetes and Related Quantitative Traits With 222 Candidate Genes
Kyle J. Gaulton; Cristen J. Willer; Yun Li; Laura J. Scott; Karen N. Conneely; Anne U. Jackson; William L. Duren; Peter S. Chines; Narisu Narisu; Lori L. Bonnycastle; Jingchun Luo; Maurine Tong; Andrew G. Sprau; Elizabeth W. Pugh; Kimberly F. Doheny; Timo T. Valle; Gonçalo R. Abecasis; Jaakko Tuomilehto; Richard N. Bergman; Francis S. Collins; Michael Boehnke; Karen L. Mohlke
Topics:
diabetes mellitus, type 2
,
genes
,
single nucleotide polymorphism
,
imputation
,
candidate disease gene
Diabetes November 2008, Vol.57, 3136-3144. doi:https://doi.org/10.2337/db07-1731
Fat Mass–and Obesity-Associated (FTO) Gene Variant Is Associated With Obesity: Longitudinal Analyses in Two Cohort Studies and Functional Test
Lu Qi; Kihwa Kang; Cuilin Zhang; Rob M. van Dam; Peter Kraft; David Hunter; Chih-Hao Lee; Frank B. Hu
Topics:
fto gene
,
obesity
,
diabetes mellitus, type 2
,
body mass index procedure
Diabetes November 2008, Vol.57, 3145-3151. doi:https://doi.org/10.2337/db08-0006
Two Single Nucleotide Polymorphisms Identify the Highest-Risk Diabetes HLA Genotype: Potential for Rapid Screening
Jennifer M. Barker; Taylor M. Triolo; Theresa A. Aly; Erin E. Baschal; Sunanda R. Babu; Adam Kretowski; Marian J. Rewers; George S. Eisenbarth
Topics:
genotype
,
human leukocyte antigens
,
rapid screening test
,
single nucleotide polymorphism
,
diabetes mellitus, type 1
Diabetes November 2008, Vol.57, 3152-3155. doi:https://doi.org/10.2337/db08-0605
PCLO Variants Are Nominally Associated With Early-Onset Type 2 Diabetes and Insulin Resistance in Pima Indians
Topics:
diabetes mellitus, type 2
,
insulin
,
single nucleotide polymorphism
,
insulin resistance
,
glucose
Diabetes November 2008, Vol.57, 3156-3160. doi:https://doi.org/10.2337/db07-1800
Population-Specific Risk of Type 2 Diabetes Conferred by HNF4A P2 Promoter Variants: A Lesson for Replication Studies
Inês Barroso; Jian’an Luan; Eleanor Wheeler; Pamela Whittaker; Jon Wasson; Eleftheria Zeggini; Michael N. Weedon; Sarah Hunt; Ranganath Venkatesh; Timothy M. Frayling; Marcos Delgado; Rosalind J. Neuman; Jinghua Zhao; Richard Sherva; Benjamin Glaser; Mark Walker; Graham Hitman; Mark I. McCarthy; Andrew T. Hattersley; M. Alan Permutt; Nicholas J. Wareham; Panagiotis Deloukas
Diabetes November 2008, Vol.57, 3161-3165. doi:https://doi.org/10.2337/db08-0719
Erratum
Erratum
Topics:
fatty acids
,
insulin secretion
,
printing
Diabetes November 2008, Vol.57, 3166. doi:https://doi.org/10.2337/db08-er11
Online Letters to the Editor
Comment on: Hosogai et al. (2007) Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation. Diabetes 56:901–911, 2007
Topics:
adipokines
,
adipose tissue
,
hypoxia
,
obesity
Diabetes November 2008, Vol.57, e15. doi:https://doi.org/10.2337/db08-0603