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Perspectives in Diabetes

The Barrier of Hypoglycemia in Diabetes

Philip E. Cryer

Abstracts

View articletitled, The Barrier of Hypoglycemia in Diabetes

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Topics: hypoglycemia , insulin , glucose

Diabetes December 2008, Vol.57, 3169-3176. doi:https://doi.org/10.2337/db08-1084

Minimizing Hypoglycemia While Maintaining Glycemic Control in Diabetes

Simon R. Heller

Abstracts

View articletitled, Minimizing Hypoglycemia While Maintaining Glycemic Control in Diabetes

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Topics: hypoglycemia , insulin , glycemic control

Diabetes December 2008, Vol.57, 3177-3183. doi:https://doi.org/10.2337/db08-1195

Commentaries

Immunopathogenic Interaction of Environmental Triggers and Genetic Susceptibility in Diabetes: Is Epigenetics the Missing Link?

Sally A. Litherland

Abstracts

View articletitled, Immunopathogenic Interaction of Environmental Triggers and Genetic Susceptibility in Diabetes: Is Epigenetics the Missing Link?

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Topics: epigenetics , genetic predisposition to disease , precipitating factors , diabetes mellitus, type 1 , histones

Diabetes December 2008, Vol.57, 3184-3186. doi:https://doi.org/10.2337/db08-1275

Challenges in Understanding Diabetic Embryopathy

Mary R. Loeken

Abstracts

View articletitled, Challenges in Understanding Diabetic Embryopathy

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Topics: congenital abnormality , embryo , pregnancy , heart , mice

Diabetes December 2008, Vol.57, 3187-3188. doi:https://doi.org/10.2337/db08-1201

New Methodologies and Databases

Lymphocytes From Patients With Type 1 Diabetes Display a Distinct Profile of Chromatin Histone H3 Lysine 9 Dimethylation : An Epigenetic Study in Diabetes

Feng Miao; David D. Smith; Lingxiao Zhang; Andrew Min; Wei Feng; Rama Natarajan

Abstracts

View articletitled, Lymphocytes From Patients With Type 1 Diabetes Display a Distinct Profile of Chromatin Histone H3 Lysine 9 Dimethylation : An Epigenetic Study in Diabetes

Supplementary data

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Topics: diabetes mellitus, type 1 , genes , histones , lymphocytes , methylation

Diabetes December 2008, Vol.57, 3189-3198. doi:https://doi.org/10.2337/db08-0645

Metabolism

Atrial Natriuretic Peptide Induces Postprandial Lipid Oxidation in Humans

Andreas L. Birkenfeld; Petra Budziarek; Michael Boschmann; Cedric Moro; Frauke Adams; Gabriele Franke; Michel Berlan; Marie A. Marques; Fred C.G.J. Sweep; Friedrich C. Luft; Max Lafontan; Jens Jordan

Abstracts

View articletitled, Atrial Natriuretic Peptide Induces Postprandial Lipid Oxidation in Humans

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Topics: atrial natriuretic factor , infusion procedures , lipids , microdialysis , oxidation

Diabetes December 2008, Vol.57, 3199-3204. doi:https://doi.org/10.2337/db08-0649

Ghrelin Infusion in Humans Induces Acute Insulin Resistance and Lipolysis Independent of Growth Hormone Signaling

Esben Thyssen Vestergaard; Lars Christian Gormsen; Niels Jessen; Sten Lund; Troels Krarup Hansen; Niels Moller; Jens Otto Lunde Jorgensen

Abstracts

View articletitled, Ghrelin Infusion in Humans Induces Acute Insulin Resistance and Lipolysis Independent of Growth Hormone Signaling

Supplementary data

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Topics: ghrelin , glucose , infusion procedures , microdialysis , signal transduction

Diabetes December 2008, Vol.57, 3205-3210. doi:https://doi.org/10.2337/db08-0025

Signal Transduction

Dual Role of Interleukin-6 in Regulating Insulin Sensitivity in Murine Skeletal Muscle

Iria Nieto-Vazquez; Sonia Fernández-Veledo; Cristina de Alvaro; Margarita Lorenzo

Abstracts

View articletitled, Dual Role of Interleukin-6 in Regulating Insulin Sensitivity in Murine Skeletal Muscle

Supplementary data

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Topics: insulin , interleukin-6 , insulin resistance , glucose uptake , mice

Diabetes December 2008, Vol.57, 3211-3221. doi:https://doi.org/10.2337/db07-1062

Upregulation of Mitochondrial Uncoupling Protein-2 by the AMP-Activated Protein Kinase in Endothelial Cells Attenuates Oxidative Stress in Diabetes

Zhonglin Xie; Junhua Zhang; Jiliang Wu; Benoit Viollet; Ming-Hui Zou

Abstracts

View articletitled, Upregulation of Mitochondrial Uncoupling Protein-2 by the AMP-Activated Protein Kinase in Endothelial Cells Attenuates Oxidative Stress in Diabetes

Supplementary data

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Topics: aica ribonucleotide , ampk , epoprostenol , glucose , oxidative stress

Diabetes December 2008, Vol.57, 3222-3230. doi:https://doi.org/10.2337/db08-0610

Obesity Studies

Fatty Acid Synthase Inhibitors Modulate Energy Balance via Mammalian Target of Rapamycin Complex 1 Signaling in the Central Nervous System

Karine Proulx; Daniela Cota; Stephen C. Woods; Randy J. Seeley

Abstracts

View articletitled, Fatty Acid Synthase Inhibitors Modulate Energy Balance via Mammalian Target of Rapamycin Complex 1 Signaling in the Central Nervous System

Supplementary data

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Topics: appetite depressants , cerulenin , hypothalamus , mechanistic target of rapamycin complex 1 , rats

Diabetes December 2008, Vol.57, 3231-3238. doi:https://doi.org/10.2337/db07-1690

Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

Carey N. Lumeng; Jennifer B. DelProposto; Daniel J. Westcott; Alan R. Saltiel

Abstracts

View articletitled, Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

Supplementary data

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Topics: adipocytes , adipose tissue , macrophages , mice , obesity

Diabetes December 2008, Vol.57, 3239-3246. doi:https://doi.org/10.2337/db08-0872

Angiogenesis Associated With Visceral and Subcutaneous Adipose Tissue in Severe Human Obesity

Séverine Ledoux; Isabelle Queguiner; Simon Msika; Sophie Calderari; Pierre Rufat; Jean-Marie Gasc; Pierre Corvol; Etienne Larger

Abstracts

View articletitled, Angiogenesis Associated With Visceral and Subcutaneous Adipose Tissue in Severe Human Obesity

Supplementary data

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Topics: adipose tissue , angiogenesis , obesity , vascular endothelial growth factor a , adipocytes

Diabetes December 2008, Vol.57, 3247-3257. doi:https://doi.org/10.2337/db07-1812

Resistance to High-Fat Diet–Induced Obesity but Exacerbated Insulin Resistance in Mice Overexpressing Preadipocyte Factor-1 (Pref-1): A New Model of Partial Lipodystrophy

Josep A. Villena; Cheol Soo Choi; Yuhui Wang; Sheene Kim; Yu-Jin Hwang; Young-Bum Kim; Gary Cline; Gerald I. Shulman; Hei Sook Sul

Abstracts

View articletitled, Resistance to High-Fat Diet–Induced Obesity but Exacerbated Insulin Resistance in Mice Overexpressing Preadipocyte Factor-1 (Pref-1): A New Model of Partial Lipodystrophy

Supplementary data

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Topics: adipose tissue , diet, high-fat , insulin , insulin resistance , lipids

Diabetes December 2008, Vol.57, 3258-3266. doi:https://doi.org/10.2337/db07-1739

Lower Metabolic Rate in Individuals Heterozygous for Either a Frameshift or a Functional Missense MC4R Variant

Jonathan Krakoff; Lijun Ma; Sayuko Kobes; William C. Knowler; Robert L. Hanson; Clifton Bogardus; Leslie J. Baier

Abstracts

View articletitled, Lower Metabolic Rate in Individuals Heterozygous for Either a Frameshift or a Functional Missense MC4R Variant

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Topics: calories , energy metabolism , heterozygote , insulin , obesity

Diabetes December 2008, Vol.57, 3267-3272. doi:https://doi.org/10.2337/db08-0577

Immunology and Transplantation

Idd9/11 Genetic Locus Regulates Diabetogenic Activity of CD4 T-Cells in Nonobese Diabetic (NOD) Mice

Yi-Guang Chen; Felix Scheuplein; Melissa A. Osborne; Shirng-Wern Tsaih; Harold D. Chapman; David V. Serreze

Abstracts

View articletitled, Idd9/11 Genetic Locus Regulates Diabetogenic Activity of CD4 T-Cells in Nonobese Diabetic (NOD) Mice

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Topics: mice , t-lymphocytes , diabetes mellitus, type 1

Diabetes December 2008, Vol.57, 3273-3280. doi:https://doi.org/10.2337/db08-0767

Islet Studies

Combination Therapy With Glucagon-Like Peptide-1 and Gastrin Restores Normoglycemia in Diabetic NOD Mice

Wilma L. Suarez-Pinzon; Robert F. Power; Yanhua Yan; Clive Wasserfall; Mark Atkinson; Alex Rabinovitch

Abstracts

View articletitled, Combination Therapy With Glucagon-Like Peptide-1 and Gastrin Restores Normoglycemia in Diabetic NOD Mice

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Topics: glucagon-like peptide 1 , insulin , mice , mice, inbred nod , pancreas

Diabetes December 2008, Vol.57, 3281-3288. doi:https://doi.org/10.2337/db08-0688

Pathophysiology

Diabetes, Abdominal Adiposity, and Atherogenic Dyslipoproteinemia in Women Compared With Men

Ken Williams; Andre Tchernof; Kelly J. Hunt; Lynne E. Wagenknecht; Steven M. Haffner; Allan D. Sniderman

Abstracts

View articletitled, Diabetes, Abdominal Adiposity, and Atherogenic Dyslipoproteinemia in Women Compared With Men

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Topics: abdomen , apolipoproteins b , diabetes in women , heart disease risk factors , lipoproteins

Diabetes December 2008, Vol.57, 3289-3296. doi:https://doi.org/10.2337/db08-0787

Intracellular Angiotensin II Production in Diabetic Rats Is Correlated With Cardiomyocyte Apoptosis, Oxidative Stress, and Cardiac Fibrosis

Vivek P. Singh; Bao Le; Renu Khode; Kenneth M. Baker; Rajesh Kumar

Abstracts

View articletitled, Intracellular Angiotensin II Production in Diabetic Rats Is Correlated With Cardiomyocyte Apoptosis, Oxidative Stress, and Cardiac Fibrosis

Supplementary data

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Topics: angiotensin ii , apoptosis , cardiac myocytes , fibrosis , heart

Diabetes December 2008, Vol.57, 3297-3306. doi:https://doi.org/10.2337/db08-0805

Effect of Endothelium-Specific Insulin Resistance on Endothelial Function In Vivo

Edward R. Duncan; Paul A. Crossey; Simon Walker; Narayana Anilkumar; Lucilla Poston; Gillian Douglas; Vivienne A. Ezzat; Stephen B. Wheatcroft; Ajay M. Shah; Mark I. Kearney

Abstracts

View articletitled, Effect of Endothelium-Specific Insulin Resistance on Endothelial Function In Vivo

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Topics: aorta , endothelial cells , endothelium , insulin , insulin receptor

Diabetes December 2008, Vol.57, 3307-3314. doi:https://doi.org/10.2337/db07-1111

Effects of the Selective Serotonin Reuptake Inhibitor Fluoxetine on Counterregulatory Responses to Hypoglycemia in Individuals With Type 1 Diabetes

Vanessa J. Briscoe; Andrew C. Ertl; Donna B. Tate; Stephen N. Davis

Abstracts

View articletitled, Effects of the Selective Serotonin Reuptake Inhibitor Fluoxetine on Counterregulatory Responses to Hypoglycemia in Individuals With Type 1 Diabetes

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Topics: diabetes mellitus, type 1 , fluoxetine , glucose , hypoglycemia , selective serotonin re-uptake inhibitors

Diabetes December 2008, Vol.57, 3315-3322. doi:https://doi.org/10.2337/db08-1000

Evidence That Kidney Function but Not Type 2 Diabetes Determines Retinol-Binding Protein 4 Serum Levels

Andrea Henze; Simone K. Frey; Jens Raila; Martin Tepel; Alexandra Scholze; Andreas F. H. Pfeiffer; Martin O. Weickert; Joachim Spranger; Florian J. Schweigert

Abstracts

View articletitled, Evidence That Kidney Function but Not Type 2 Diabetes Determines Retinol-Binding Protein 4 Serum Levels

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Topics: diabetes mellitus, type 2 , prealbumin , renal function , retinol binding proteins , serum drug concentration

Diabetes December 2008, Vol.57, 3323-3326. doi:https://doi.org/10.2337/db08-0866

Complications

Amplified Hormonal Counterregulatory Responses to Hypoglycemia in Rats After Systemic Delivery of a SUR-1–Selective K⁺ Channel Opener?

Xiaoning Fan; Yuyan Ding; Haiying Cheng; Dorte X. Gram; Robert S. Sherwin; Rory J. McCrimmon

Abstracts

View articletitled, Amplified Hormonal Counterregulatory Responses to Hypoglycemia in Rats After Systemic Delivery of a SUR-1–Selective K+ Channel Opener?

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Topics: epinephrine , hypoglycemia , glucose , rats , hypoglycemic agents

Diabetes December 2008, Vol.57, 3327-3334. doi:https://doi.org/10.2337/db08-0793

Ang-1 Gene Therapy Inhibits Hypoxia-Inducible Factor-1α (HIF-1α)-Prolyl-4-Hydroxylase-2, Stabilizes HIF-1α Expression, and Normalizes Immature Vasculature in db/db Mice

Jian-Xiong Chen; Amanda Stinnett

Abstracts

View articletitled, Ang-1 Gene Therapy Inhibits Hypoxia-Inducible Factor-1α (HIF-1α)-Prolyl-4-Hydroxylase-2, Stabilizes HIF-1α Expression, and Normalizes Immature Vasculature in db/db Mice

Supplementary data

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Topics: ischemia , mice , myocardium , protein overexpression , heart

Diabetes December 2008, Vol.57, 3335-3343. doi:https://doi.org/10.2337/db08-0503

Decreased Cardiac Glutathione Peroxidase Levels and Enhanced Mandibular Apoptosis in Malformed Embryos of Diabetic Rats

Parri Wentzel; Mattias Gäreskog; Ulf J. Eriksson

Abstracts

View articletitled, Decreased Cardiac Glutathione Peroxidase Levels and Enhanced Mandibular Apoptosis in Malformed Embryos of Diabetic Rats

Supplementary data

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Topics: embryo , rats , congenital abnormality , rna, messenger , glutathione peroxidase

Diabetes December 2008, Vol.57, 3344-3352. doi:https://doi.org/10.2337/db08-0830

Genetics

Common Variants in the Adiponectin Gene (ADIPOQ) Associated With Plasma Adiponectin Levels, Type 2 Diabetes, and Diabetes-Related Quantitative Traits: The Framingham Offspring Study

Marie-France Hivert; Alisa K. Manning; Jarred B. McAteer; Jose C. Florez; Josée Dupuis; Caroline S. Fox; Christopher J. O'Donnell; L. Adrienne Cupples; James B. Meigs

Abstracts

View articletitled, Common Variants in the Adiponectin Gene (ADIPOQ) Associated With Plasma Adiponectin Levels, Type 2 Diabetes, and Diabetes-Related Quantitative Traits: The Framingham Offspring Study

Supplementary data

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Topics: adiponectin , single nucleotide polymorphism , genes , framingham offspring study

Diabetes December 2008, Vol.57, 3353-3359. doi:https://doi.org/10.2337/db08-0700

Role of the ENPP1 K121Q Polymorphism in Glucose Homeostasis

Roberto Baratta; Paola Rossetti; Sabrina Prudente; Fabrizio Barbetti; Dora Sudano; Angela Nigro; Maria Grazia Farina; Fabio Pellegrini; Vincenzo Trischitta; Lucia Frittitta

Abstracts

View articletitled, Role of the ENPP1 K121Q Polymorphism in Glucose Homeostasis

Supplementary data

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Topics: body mass index procedure , childhood obesity , diabetes mellitus, type 2 , genotype , glucose

Diabetes December 2008, Vol.57, 3360-3364. doi:https://doi.org/10.2337/db07-1830

Online Letters to the Editor

Comment on: Wanic et al. (2008) Exclusion of Polymorphisms in Carnosinase Genes (CNDP1 and CNDP2) as a Cause of Diabetic Nephropathy in Type 1 Diabetes: Results of Large Case-Control and Follow-Up Studies: Diabetes 57:2547–2551, 2008

Stephan J.L. Bakker; Alaa Alkhalaf; Lise Tarnow; Gerjan Navis

Abstracts

View articletitled, Comment on: Wanic et al. (2008) Exclusion of Polymorphisms in Carnosinase Genes (CNDP1 and CNDP2) as a Cause of Diabetic Nephropathy in Type 1 Diabetes: Results of Large Case-Control and Follow-Up Studies: Diabetes 57:2547–2551, 2008

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Topics: diabetes mellitus, type 1 , diabetic nephropathy , follow-up , genes , polymorphism

Diabetes December 2008, Vol.57, e16. doi:https://doi.org/10.2337/db08-1120

Response to Comment on: Wanic et al. (2008) Exclusion of Polymorphisms in Carnosinase Genes (CNDP1 and CNDP2) as a Cause of Diabetic Nephropathy in Type 1 Diabetes: Results of Large Case-Control and Follow-Up Studies: Diabetes 57:2547–2551, 2008

Adam Smiles; Krzysztof Wanic; James H. Warram; Andrzej S. Krolewski

Abstracts

View articletitled, Response to Comment on: Wanic et al. (2008) Exclusion of Polymorphisms in Carnosinase Genes (CNDP1 and CNDP2) as a Cause of Diabetic Nephropathy in Type 1 Diabetes: Results of Large Case-Control and Follow-Up Studies: Diabetes 57:2547–2551, 2008

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Topics: diabetes mellitus, type 1 , diabetic nephropathy , follow-up , genes , polymorphism

Diabetes December 2008, Vol.57, e17. doi:https://doi.org/10.2337/db08-1190

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