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Issues
Perspectives in Diabetes
The Barrier of Hypoglycemia in Diabetes
Diabetes December 2008, Vol.57, 3169-3176. doi:https://doi.org/10.2337/db08-1084
Minimizing Hypoglycemia While Maintaining Glycemic Control in Diabetes
Diabetes December 2008, Vol.57, 3177-3183. doi:https://doi.org/10.2337/db08-1195
Commentaries
Immunopathogenic Interaction of Environmental Triggers and Genetic Susceptibility in Diabetes: Is Epigenetics the Missing Link?
Diabetes December 2008, Vol.57, 3184-3186. doi:https://doi.org/10.2337/db08-1275
Challenges in Understanding Diabetic Embryopathy
Diabetes December 2008, Vol.57, 3187-3188. doi:https://doi.org/10.2337/db08-1201
New Methodologies and Databases
Lymphocytes From Patients With Type 1 Diabetes Display a Distinct Profile of Chromatin Histone H3 Lysine 9 Dimethylation : An Epigenetic Study in Diabetes
Diabetes December 2008, Vol.57, 3189-3198. doi:https://doi.org/10.2337/db08-0645
Metabolism
Atrial Natriuretic Peptide Induces Postprandial Lipid Oxidation in Humans
Andreas L. Birkenfeld; Petra Budziarek; Michael Boschmann; Cedric Moro; Frauke Adams; Gabriele Franke; Michel Berlan; Marie A. Marques; Fred C.G.J. Sweep; Friedrich C. Luft; Max Lafontan; Jens Jordan
Diabetes December 2008, Vol.57, 3199-3204. doi:https://doi.org/10.2337/db08-0649
Ghrelin Infusion in Humans Induces Acute Insulin Resistance and Lipolysis Independent of Growth Hormone Signaling
Esben Thyssen Vestergaard; Lars Christian Gormsen; Niels Jessen; Sten Lund; Troels Krarup Hansen; Niels Moller; Jens Otto Lunde Jorgensen
Diabetes December 2008, Vol.57, 3205-3210. doi:https://doi.org/10.2337/db08-0025
Signal Transduction
Dual Role of Interleukin-6 in Regulating Insulin Sensitivity in Murine Skeletal Muscle
Diabetes December 2008, Vol.57, 3211-3221. doi:https://doi.org/10.2337/db07-1062
Upregulation of Mitochondrial Uncoupling Protein-2 by the AMP-Activated Protein Kinase in Endothelial Cells Attenuates Oxidative Stress in Diabetes
Diabetes December 2008, Vol.57, 3222-3230. doi:https://doi.org/10.2337/db08-0610
Obesity Studies
Fatty Acid Synthase Inhibitors Modulate Energy Balance via Mammalian Target of Rapamycin Complex 1 Signaling in the Central Nervous System
Diabetes December 2008, Vol.57, 3231-3238. doi:https://doi.org/10.2337/db07-1690
Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes
Diabetes December 2008, Vol.57, 3239-3246. doi:https://doi.org/10.2337/db08-0872
Angiogenesis Associated With Visceral and Subcutaneous Adipose Tissue in Severe Human Obesity
Séverine Ledoux; Isabelle Queguiner; Simon Msika; Sophie Calderari; Pierre Rufat; Jean-Marie Gasc; Pierre Corvol; Etienne Larger
Diabetes December 2008, Vol.57, 3247-3257. doi:https://doi.org/10.2337/db07-1812
Resistance to High-Fat Diet–Induced Obesity but Exacerbated Insulin Resistance in Mice Overexpressing Preadipocyte Factor-1 (Pref-1): A New Model of Partial Lipodystrophy
Josep A. Villena; Cheol Soo Choi; Yuhui Wang; Sheene Kim; Yu-Jin Hwang; Young-Bum Kim; Gary Cline; Gerald I. Shulman; Hei Sook Sul
Diabetes December 2008, Vol.57, 3258-3266. doi:https://doi.org/10.2337/db07-1739
Lower Metabolic Rate in Individuals Heterozygous for Either a Frameshift or a Functional Missense MC4R Variant
Jonathan Krakoff; Lijun Ma; Sayuko Kobes; William C. Knowler; Robert L. Hanson; Clifton Bogardus; Leslie J. Baier
Diabetes December 2008, Vol.57, 3267-3272. doi:https://doi.org/10.2337/db08-0577
Immunology and Transplantation
Idd9/11 Genetic Locus Regulates Diabetogenic Activity of CD4 T-Cells in Nonobese Diabetic (NOD) Mice
Yi-Guang Chen; Felix Scheuplein; Melissa A. Osborne; Shirng-Wern Tsaih; Harold D. Chapman; David V. Serreze
Diabetes December 2008, Vol.57, 3273-3280. doi:https://doi.org/10.2337/db08-0767
Islet Studies
Combination Therapy With Glucagon-Like Peptide-1 and Gastrin Restores Normoglycemia in Diabetic NOD Mice
Wilma L. Suarez-Pinzon; Robert F. Power; Yanhua Yan; Clive Wasserfall; Mark Atkinson; Alex Rabinovitch
Diabetes December 2008, Vol.57, 3281-3288. doi:https://doi.org/10.2337/db08-0688
Pathophysiology
Diabetes, Abdominal Adiposity, and Atherogenic Dyslipoproteinemia in Women Compared With Men
Ken Williams; Andre Tchernof; Kelly J. Hunt; Lynne E. Wagenknecht; Steven M. Haffner; Allan D. Sniderman
Diabetes December 2008, Vol.57, 3289-3296. doi:https://doi.org/10.2337/db08-0787
Intracellular Angiotensin II Production in Diabetic Rats Is Correlated With Cardiomyocyte Apoptosis, Oxidative Stress, and Cardiac Fibrosis
Diabetes December 2008, Vol.57, 3297-3306. doi:https://doi.org/10.2337/db08-0805
Effect of Endothelium-Specific Insulin Resistance on Endothelial Function In Vivo
Edward R. Duncan; Paul A. Crossey; Simon Walker; Narayana Anilkumar; Lucilla Poston; Gillian Douglas; Vivienne A. Ezzat; Stephen B. Wheatcroft; Ajay M. Shah; Mark I. Kearney
Diabetes December 2008, Vol.57, 3307-3314. doi:https://doi.org/10.2337/db07-1111
Effects of the Selective Serotonin Reuptake Inhibitor Fluoxetine on Counterregulatory Responses to Hypoglycemia in Individuals With Type 1 Diabetes
Diabetes December 2008, Vol.57, 3315-3322. doi:https://doi.org/10.2337/db08-1000
Evidence That Kidney Function but Not Type 2 Diabetes Determines Retinol-Binding Protein 4 Serum Levels
Andrea Henze; Simone K. Frey; Jens Raila; Martin Tepel; Alexandra Scholze; Andreas F. H. Pfeiffer; Martin O. Weickert; Joachim Spranger; Florian J. Schweigert
Diabetes December 2008, Vol.57, 3323-3326. doi:https://doi.org/10.2337/db08-0866
Complications
Amplified Hormonal Counterregulatory Responses to Hypoglycemia in Rats After Systemic Delivery of a SUR-1–Selective K+ Channel Opener?
Diabetes December 2008, Vol.57, 3327-3334. doi:https://doi.org/10.2337/db08-0793
Decreased Cardiac Glutathione Peroxidase Levels and Enhanced Mandibular Apoptosis in Malformed Embryos of Diabetic Rats
Diabetes December 2008, Vol.57, 3344-3352. doi:https://doi.org/10.2337/db08-0830
Genetics
Common Variants in the Adiponectin Gene (ADIPOQ) Associated With Plasma Adiponectin Levels, Type 2 Diabetes, and Diabetes-Related Quantitative Traits: The Framingham Offspring Study
Marie-France Hivert; Alisa K. Manning; Jarred B. McAteer; Jose C. Florez; Josée Dupuis; Caroline S. Fox; Christopher J. O'Donnell; L. Adrienne Cupples; James B. Meigs
Diabetes December 2008, Vol.57, 3353-3359. doi:https://doi.org/10.2337/db08-0700
Role of the ENPP1 K121Q Polymorphism in Glucose Homeostasis
Roberto Baratta; Paola Rossetti; Sabrina Prudente; Fabrizio Barbetti; Dora Sudano; Angela Nigro; Maria Grazia Farina; Fabio Pellegrini; Vincenzo Trischitta; Lucia Frittitta
Diabetes December 2008, Vol.57, 3360-3364. doi:https://doi.org/10.2337/db07-1830
Online Letters to the Editor
Comment on: Wanic et al. (2008) Exclusion of Polymorphisms in Carnosinase Genes (CNDP1 and CNDP2) as a Cause of Diabetic Nephropathy in Type 1 Diabetes: Results of Large Case-Control and Follow-Up Studies: Diabetes 57:2547–2551, 2008
Diabetes December 2008, Vol.57, e16. doi:https://doi.org/10.2337/db08-1120
Response to Comment on: Wanic et al. (2008) Exclusion of Polymorphisms in Carnosinase Genes (CNDP1 and CNDP2) as a Cause of Diabetic Nephropathy in Type 1 Diabetes: Results of Large Case-Control and Follow-Up Studies: Diabetes 57:2547–2551, 2008
Diabetes December 2008, Vol.57, e17. doi:https://doi.org/10.2337/db08-1190