Skip Nav Destination
Issues
Metabolism
Impaired Glucose-Stimulated Insulin Secretion Is Coupled With Exocrine Pancreatic Lesions in the Cohen Diabetic Rat
Sarah Weksler-Zangen; Itamar Raz; Sigurd Lenzen; Anne Jörns; Shira Ehrenfeld; Gail Amir; Andrei Oprescu; Yoram Yagil; Chana Yagil; David H. Zangen; Nurit Kaiser
Diabetes February 2008, Vol.57, 279-287. doi:https://doi.org/10.2337/db07-0520
Insulin Action in the Double Incretin Receptor Knockout Mouse
Julio E. Ayala; Deanna P. Bracy; Tanya Hansotia; Grace Flock; Yutaka Seino; David H. Wasserman; Daniel J. Drucker
Diabetes February 2008, Vol.57, 288-297. doi:https://doi.org/10.2337/db07-0704
25-Hydroxyvitamin D, IGF-1, and Metabolic Syndrome at 45 Years of Age: A Cross-Sectional Study in the 1958 British Birth Cohort
Diabetes February 2008, Vol.57, 298-305. doi:https://doi.org/10.2337/db07-1122
Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase–Dependent Regulation of the Orphan Nuclear Receptor SHP
Yong Deuk Kim; Keun-Gyu Park; Yong-Soo Lee; Yun-Yong Park; Don-Kyu Kim; Balachandar Nedumaran; Won Gu Jang; Won-Jea Cho; Joohun Ha; In-Kyu Lee; Chul-Ho Lee; Hueng-Sik Choi
Diabetes February 2008, Vol.57, 306-314. doi:https://doi.org/10.2337/db07-0381
Large GLUT4 Vesicles Are Stationary While Locally and Reversibly Depleted During Transient Insulin Stimulation of Skeletal Muscle of Living Mice: Imaging Analysis of GLUT4–Enhanced Green Fluorescent Protein Vesicle Dynamics
Diabetes February 2008, Vol.57, 315-324. doi:https://doi.org/10.2337/db06-1578
Glucagon-Like Peptide-1 Inhibits Blood-Brain Glucose Transfer in Humans
Susanne Lerche; Birgitte Brock; Jørgen Rungby; Hans E. Bøtker; Niels Møller; Anders Rodell; Bo Martin Bibby; Jens J. Holst; Ole Schmitz; Albert Gjedde
Diabetes February 2008, Vol.57, 325-331. doi:https://doi.org/10.2337/db07-1162
Activation of Peroxisome Proliferator–Activated Receptor (PPAR)δ Promotes Reversal of Multiple Metabolic Abnormalities, Reduces Oxidative Stress, and Increases Fatty Acid Oxidation in Moderately Obese Men
Ulf Risérus; Dennis Sprecher; Tony Johnson; Eric Olson; Sandra Hirschberg; Aixue Liu; Zeke Fang; Priti Hegde; Duncan Richards; Leli Sarov-Blat; Jay C. Strum; Samar Basu; Jane Cheeseman; Barbara A. Fielding; Sandy M. Humphreys; Theodore Danoff; Niall R. Moore; Peter Murgatroyd; Stephen O'Rahilly; Pauline Sutton; Tim Willson; David Hassall; Keith N. Frayn; Fredrik Karpe
Diabetes February 2008, Vol.57, 332-339. doi:https://doi.org/10.2337/db07-1318
Mas Deficiency in FVB/N Mice Produces Marked Changes in Lipid and Glycemic Metabolism
Sérgio Henrique S. Santos; Luciana Rodrigues Fernandes; Érica Guilhen Mario; Adaliene Versiani M. Ferreira; Laura Cristina J. Pôrto; Jaqueline Isaura Alvarez-Leite; Leida Maria Botion; Michael Bader; Natalia Alenina; Robson Augusto S. Santos
Diabetes February 2008, Vol.57, 340-347. doi:https://doi.org/10.2337/db07-0953
Signal Transduction
Fas-Associated Death Receptor Signaling Evoked by Human Amylin in Islet β-Cells
Diabetes February 2008, Vol.57, 348-356. doi:https://doi.org/10.2337/db07-0849
Impaired Insulin-Stimulated Phosphorylation of Akt and AS160 in Skeletal Muscle of Women With Polycystic Ovary Syndrome Is Reversed by Pioglitazone Treatment
Kurt Højlund; Dorte Glintborg; Nicoline R. Andersen; Jesper B. Birk; Jonas T. Treebak; Christian Frøsig; Henning Beck-Nielsen; Jørgen F.P. Wojtaszewski
Diabetes February 2008, Vol.57, 357-366. doi:https://doi.org/10.2337/db07-0706
Obesity Studies
High Visceral and Low Abdominal Subcutaneous Fat Stores in the Obese Adolescent: A Determinant of an Adverse Metabolic Phenotype
Sara E. Taksali; Sonia Caprio; James Dziura; Sylvie Dufour; Anna M.G. Calí; T. Robin Goodman; Xenophon Papademetris; Tania S. Burgert; Bridget M. Pierpont; Mary Savoye; Melissa Shaw; Aisha A. Seyal; Ram Weiss
Diabetes February 2008, Vol.57, 367-371. doi:https://doi.org/10.2337/db07-0932
Serum Vaspin Concentrations in Human Obesity and Type 2 Diabetes
Byung-Soo Youn; Nora Klöting; Jürgen Kratzsch; Namseok Lee; Ji Woo Park; Eun-Sun Song; Karen Ruschke; Andreas Oberbach; Mathias Fasshauer; Michael Stumvoll; Matthias Blüher
Diabetes February 2008, Vol.57, 372-377. doi:https://doi.org/10.2337/db07-1045
Vascular Peptide Endothelin-1 Links Fat Accumulation With Alterations of Visceral Adipocyte Lipolysis
Vanessa van Harmelen; Anna Eriksson; Gaby Åström; Kerstin Wåhlén; Erik Näslund; Fredrik Karpe; Keith Frayn; Tommy Olsson; Jonas Andersson; Mikel Rydén; Peter Arner
Diabetes February 2008, Vol.57, 378-386. doi:https://doi.org/10.2337/db07-0893
Immunology and Transplantation
Islet Expression of M3 Uncovers a Key Role for Chemokines in the Development and Recruitment of Diabetogenic Cells in NOD Mice
Andrea P. Martin; Marcos G. Grisotto; Claudia Canasto-Chibuque; Steven L. Kunkel; Jonathan S. Bromberg; Glaucia C. Furtado; Sergio A. Lira
Diabetes February 2008, Vol.57, 387-394. doi:https://doi.org/10.2337/db07-1309
Marginal-Zone B-Cells of Nonobese Diabetic Mice Expand With Diabetes Onset, Invade the Pancreatic Lymph Nodes, and Present Autoantigen to Diabetogenic T-Cells
Eliana Mariño; Marcel Batten; Joanna Groom; Stacey Walters; David Liuwantara; Fabienne Mackay; Shane T. Grey
Diabetes February 2008, Vol.57, 395-404. doi:https://doi.org/10.2337/db07-0589
Murine Antithymocyte Globulin Therapy Alters Disease Progression in NOD Mice by a Time-Dependent Induction of Immunoregulation
Greg Simon; Matthew Parker; Vijayakumar Ramiya; Clive Wasserfall; Yanfei Huang; Damien Bresson; R. Fletcher Schwartz; Martha Campbell-Thompson; Lauren Tenace; Todd Brusko; Song Xue; Abraham Scaria; Michael Lukason; Scott Eisenbeis; John Williams; Michael Clare-Salzler; Desmond Schatz; Bruce Kaplan; Matthias Von Herrath; Karl Womer; Mark A. Atkinson
Diabetes February 2008, Vol.57, 405-414. doi:https://doi.org/10.2337/db06-1384
Islet Studies
Inhibition of AMP-Activated Protein Kinase Protects Pancreatic β-Cells From Cytokine-Mediated Apoptosis and CD8+ T-Cell–Induced Cytotoxicity
Diabetes February 2008, Vol.57, 415-423. doi:https://doi.org/10.2337/db07-0993
Cyclical and Alternating Infusions of Glucose and Intralipid in Rats Inhibit Insulin Gene Expression and Pdx-1 Binding in Islets
Derek K. Hagman; Martin G. Latour; Swarup K. Chakrabarti; Ghislaine Fontes; Julie Amyot; Caroline Tremblay; Meriem Semache; James A. Lausier; Violet Roskens; Raghavendra G. Mirmira; Thomas L. Jetton; Vincent Poitout
Diabetes February 2008, Vol.57, 424-431. doi:https://doi.org/10.2337/db07-1285
Pathophysiology
Thrombospondin-1 Is an Adipokine Associated With Obesity, Adipose Inflammation, and Insulin Resistance
Vijayalakshmi Varma; Aiwei Yao-Borengasser; Angela M. Bodles; Neda Rasouli; Bounleut Phanavanh; Greg T. Nolen; Emily M. Kern; Radhakrishnan Nagarajan; Horace J. Spencer, III; Mi-Jeong Lee; Susan K. Fried; Robert E. McGehee, Jr.; Charlotte A. Peterson; Philip A. Kern
Diabetes February 2008, Vol.57, 432-439. doi:https://doi.org/10.2337/db07-0840
Complications
Increased Glucose Levels Are Associated With Episodic Memory in Nondiabetic Women
Diabetes February 2008, Vol.57, 440-443. doi:https://doi.org/10.2337/db07-1215
Key Role for AMP-Activated Protein Kinase in the Ventromedial Hypothalamus in Regulating Counterregulatory Hormone Responses to Acute Hypoglycemia
Rory J. McCrimmon; Margaret Shaw; Xiaoning Fan; Haiying Cheng; Yuyan Ding; Monica C. Vella; Ligang Zhou; Ewan C. McNay; Robert S. Sherwin
Diabetes February 2008, Vol.57, 444-450. doi:https://doi.org/10.2337/db07-0837
Attenuation of Interstitial Fibrosis and Tubular Apoptosis in db/db Transgenic Mice Overexpressing Catalase in Renal Proximal Tubular Cells
Marie-Luise Brezniceanu; Fang Liu; Chih-Chang Wei; Isabelle Chénier; Nicolas Godin; Shao-Ling Zhang; Janos G. Filep; Julie R. Ingelfinger; John S.D. Chan
Diabetes February 2008, Vol.57, 451-459. doi:https://doi.org/10.2337/db07-0013
Inhibition of NADPH Oxidase Prevents Advanced Glycation End Product–Mediated Damage in Diabetic Nephropathy Through a Protein Kinase C-α–Dependent Pathway
Vicki Thallas-Bonke; Suzanne R. Thorpe; Melinda T. Coughlan; Kei Fukami; Felicia Y.T. Yap; Karly C. Sourris; Sally A. Penfold; Leon A. Bach; Mark E. Cooper; Josephine M. Forbes
Diabetes February 2008, Vol.57, 460-469. doi:https://doi.org/10.2337/db07-1119
In Vivo Effects of Insulin and Free Fatty Acids on Matrix Metalloproteinases in Rat Aorta
Diabetes February 2008, Vol.57, 476-483. doi:https://doi.org/10.2337/db07-1261
Pharmacology and Therapeutics
Sphingosine-1-Phosphate Reduces CD4+ T-Cell Activation in Type 1 Diabetes Through Regulation of Hypoxia-Inducible Factor Short Isoform I.1 and CD69
Suseela Srinivasan; David T. Bolick; Dmitriy Lukashev; Courtney Lappas; Michail Sitkovsky; Kevin R. Lynch; Catherine C. Hedrick
Diabetes February 2008, Vol.57, 484-493. doi:https://doi.org/10.2337/db07-0855
Genetics
Association Analysis Indicates That a Variant GATA-Binding Site in the PIK3CB Promoter Is a Cis-Acting Expression Quantitative Trait Locus for This Gene and Attenuates Insulin Resistance in Obese Children
Catherine Le Stunff; Agnès Dechartres; Virginie Mariot; Chantal Lotton; Cecelia Trainor; Emanuele Miraglia Del Giudice; David Meyre; Ivan Bieche; Ingrid Laurendeau; Philippe Froguel; Diana Zelenika; Dani Fallin; Mark Lathrop; Paul-Henri Roméo; Pierre Bougnères
Diabetes February 2008, Vol.57, 494-502. doi:https://doi.org/10.2337/db07-1273
The Type and the Position of HNF1A Mutation Modulate Age at Diagnosis of Diabetes in Patients with Maturity-Onset Diabetes of the Young (MODY)-3
Christine Bellanné-Chantelot; Claire Carette; Jean-Pierre Riveline; René Valéro; Jean-François Gautier; Etienne Larger; Yves Reznik; Pierre-Henri Ducluzeau; Agnès Sola; Agnès Hartemann-Heurtier; Pierre Lecomte; Lucy Chaillous; Marie Laloi-Michelin; Jean-Marie Wilhem; Pierre Cuny; Françoise Duron; Bruno Guerci; Nathalie Jeandidier; Helen Mosnier-Pudar; Michel Assayag; Danièle Dubois-Laforgue; Gilberto Velho; José Timsit
Diabetes February 2008, Vol.57, 503-508. doi:https://doi.org/10.2337/db07-0859
Association of the ATP-Binding Cassette Transporter A1 R230C Variant With Early-Onset Type 2 Diabetes in a Mexican Population
M. Teresa Villarreal-Molina; M. Teresa Flores-Dorantes; Olimpia Arellano-Campos; Marisela Villalobos-Comparan; Maricela Rodríguez-Cruz; Angel Miliar-García; Adriana Huertas-Vazquez; Marta Menjivar; Sandra Romero-Hidalgo; Niels H. Wacher; M. Teresa Tusie-Luna; Miguel Cruz; Carlos A. Aguilar-Salinas; Samuel Canizales-Quinteros; the Metabolic Study Group
Diabetes February 2008, Vol.57, 509-513. doi:https://doi.org/10.2337/db07-0484
A Candidate Type 2 Diabetes Polymorphism Near the HHEX Locus Affects Acute Glucose-Stimulated Insulin Release in European Populations : Results from the EUGENE2 study
Harald Staiger; Alena Stančáková; Jone Zilinskaite; Markku Vänttinen; Torben Hansen; Maria Adelaide Marini; Ann Hammarstedt; Per-Anders Jansson; Giorgio Sesti; Ulf Smith; Oluf Pedersen; Markku Laakso; Norbert Stefan; Andreas Fritsche; Hans-Ulrich Häring
Diabetes February 2008, Vol.57, 514-517. doi:https://doi.org/10.2337/db07-1254
Nephropathy in Type 1 Diabetes Is Diminished in Carriers of HLA-DRB1*04 : The Genetics of Kidneys in Diabetes (GoKinD) Study
Suzanne K. Cordovado; Yuan Zhao; James H. Warram; Hongguang Gong; Karen L. Anderson; Miyono M. Hendrix; Laura N. Hancock; Patricia A. Cleary; Patricia W. Mueller
Diabetes February 2008, Vol.57, 518-522. doi:https://doi.org/10.2337/db07-0826
Erratum
Online Letters to the Editor
Response to Comment on: Lachin et al. (2007) The Hemoglobin Glycation Index Is Not an Independent Predictor of the Risk of Microvascular Complications in the Diabetes Control and Complications Trial: Diabetes 56:1913–1921, 2007
Diabetes February 2008, Vol.57, e5. doi:https://doi.org/10.2337/db07-1638
