Issues

Topics: diabetes mellitus, type 1 , fetus , graft survival , pancreas transplantation , pregnancy trimester, first

Diabetes March 2008, Vol.57, 525-526. doi:https://doi.org/10.2337/db07-1409

HLA on Chromosome 6: The Story Gets Longer and Longer

Leslie J. Raffel; Janelle A. Noble; Jerome I. Rotter

Abstracts

Topics: human leukocyte antigens , chromosomes, human, pair 6 , diabetes mellitus, type 1

Diabetes March 2008, Vol.57, 527-528. doi:https://doi.org/10.2337/db07-1756

β-Cell Replication by Loosening the Brakes of Glucagon-Like Peptide-1 Receptor Signaling

Frans C. Schuit; Daniel J. Drucker

Abstracts

Topics: glucagon-like peptide 1 , glucagon-like peptide-1 receptor , signal transduction

Diabetes March 2008, Vol.57, 529-531. doi:https://doi.org/10.2337/db07-1578

Rho Kinase Inhibition: A New Approach for Treating Diabetic Nephropathy?

Leon A. Bach

Abstracts

Topics: diabetic nephropathy , phosphotransferases , rhoa gtp-binding protein , kidney diseases

Diabetes March 2008, Vol.57, 532-533. doi:https://doi.org/10.2337/db07-1768

Interaction Between Exercise and Leptin in the Treatment of Obesity

Christopher Morrison

Abstracts

Topics: leptin , obesity

Diabetes March 2008, Vol.57, 534-535. doi:https://doi.org/10.2337/db08-0007

New Methodologies and Databases

Retinal Arteriolar Narrowing Predicts Incidence of Diabetes : The Australian Diabetes, Obesity and Lifestyle (AusDiab) Study

Thanh T. Nguyen; Jie Jin Wang; F.M. Amirul Islam; Paul Mitchell; Robyn J. Tapp; Paul Z. Zimmet; Richard Simpson; Jonathan Shaw; Tien Y. Wong

Abstracts

Topics: fasting , impaired fasting glucose , life style , obesity , retinal diseases

Diabetes March 2008, Vol.57, 536-539. doi:https://doi.org/10.2337/db07-1376

Metabolism

Insulin Signaling Stimulates Insulin Transport by Bovine Aortic Endothelial Cells

Hong Wang; Aileen X. Wang; Zhenqi Liu; Eugene J. Barrett

Abstracts

Topics: endothelial cells , fluorescein-5-isothiocyanate , insulin , tumor necrosis factors , insulin receptor

Diabetes March 2008, Vol.57, 540-547. doi:https://doi.org/10.2337/db07-0967

The Role of Free-Living Daily Walking in Human Weight Gain and Obesity

James A. Levine; Shelly K. McCrady; Lorraine M. Lanningham-Foster; Paul H. Kane; Randal C. Foster; Chinmay U. Manohar

Abstracts

Topics: obesity , overnutrition , weight gain

Diabetes March 2008, Vol.57, 548-554. doi:https://doi.org/10.2337/db07-0815

Insulin Internalizes GLUT2 in the Enterocytes of Healthy but Not Insulin-Resistant Mice

Vanessa Tobin; Maude Le Gall; Xavier Fioramonti; Emilie Stolarczyk; Alba G. Blazquez; Christophe Klein; Magali Prigent; Patricia Serradas; Marie-Hélène Cuif; Christophe Magnan; Armelle Leturque; Edith Brot-Laroche

Abstracts

Topics: fructose , insulin , mice , sugars , tissue membrane

Diabetes March 2008, Vol.57, 555-562. doi:https://doi.org/10.2337/db07-0928

Forkhead Transcription Factor FoxO1 in Adipose Tissue Regulates Energy Storage and Expenditure

Jun Nakae; Yongheng Cao; Miyo Oki; Yasuko Orba; Hirofumi Sawa; Hiroshi Kiyonari; Kristy Iskandar; Koji Suga; Marc Lombes; Yoshitake Hayashi

Abstracts

Topics: forkhead box protein o1 , adipocytes , adipose tissue , mice, transgenic

Diabetes March 2008, Vol.57, 563-576. doi:https://doi.org/10.2337/db07-0698

Signal Transduction

Resistin Impairs Insulin-Evoked Vasodilation

Maria Teresa Gentile; Carmine Vecchione; Gennaro Marino; Alessandra Aretini; Alba Di Pardo; Giovanna Antenucci; Angelo Maffei; Giuseppe Cifelli; Luca Iorio; Alessandro Landolfi; Giacomo Frati; Giuseppe Lembo

Abstracts

Topics: insulin , resistin , nitric oxide synthase , irs1 protein, human , endothelium

Diabetes March 2008, Vol.57, 577-583. doi:https://doi.org/10.2337/db07-0557

Increasing GLP-1–Induced β-Cell Proliferation by Silencing the Negative Regulators of Signaling cAMP Response Element Modulator-α and DUSP14

Sonia Klinger; Carine Poussin; Marie-Bernard Debril; Wanda Dolci; Philippe A. Halban; Bernard Thorens

Abstracts

Topics: cyclic amp , glucagon-like peptide 1

Diabetes March 2008, Vol.57, 584-593. doi:https://doi.org/10.2337/db07-1414

Obesity Studies

A Central Role for Neuronal AMP-Activated Protein Kinase (AMPK) and Mammalian Target of Rapamycin (mTOR) in High-Protein Diet–Induced Weight Loss

Eduardo R. Ropelle; José R. Pauli; Maria Fernanda A. Fernandes; Silvana A. Rocco; Rodrigo M. Marin; Joseane Morari; Kellen K. Souza; Marília M. Dias; Maria C. Gomes-Marcondes; José A.R. Gontijo; Kleber G. Franchini; Lício A. Velloso; Mario J.A. Saad; José B.C. Carvalheira

Abstracts

Topics: ampk , hypothalamus , leucine , mtor serine-threonine kinases , diet

Diabetes March 2008, Vol.57, 594-605. doi:https://doi.org/10.2337/db07-0573

Increased Skeletal Muscle Tumor Necrosis Factor-α and Impaired Insulin Signaling Persist in Obese Women With Gestational Diabetes Mellitus 1 Year Postpartum

Jacob E. Friedman; John P. Kirwan; Ming Jing; Larraine Presley; Patrick M. Catalano

Abstracts

Topics: insulin , late stage of pregnancy , obesity , postpartum period , skeletal muscles

Diabetes March 2008, Vol.57, 606-613. doi:https://doi.org/10.2337/db07-1356

Synergy Between Leptin Therapy and a Seemingly Negligible Amount of Voluntary Wheel Running Prevents Progression of Dietary Obesity in Leptin-Resistant Rats

Alexandra Shapiro; Michael Matheny; Yi Zhang; Nihal Tümer; Kit-Yan Cheng; Enda Rogrigues; Sergei Zolotukhin; Philip J. Scarpace

Abstracts

Topics: diet , leptin , rats , obesity

Diabetes March 2008, Vol.57, 614-622. doi:https://doi.org/10.2337/db07-0863

Evidence of an Influence of a Polymorphism Near the INSIG2 on Weight Loss During a Lifestyle Intervention in Obese Children and Adolescents

Thomas Reinehr; Anke Hinney; Thuy Trang Nguyen; Johannes Hebebrand

Abstracts

Topics: child , childhood obesity , polymorphism , weight reduction , chief complaint

Diabetes March 2008, Vol.57, 623-626. doi:https://doi.org/10.2337/db07-0408

Immunology and Transplantation

Reduced Immunogenicity of First-Trimester Human Fetal Pancreas

Kerstin Brands; Emily Colvin; Lindy J. Williams; Rennian Wang; Richard B. Lock; Bernard E. Tuch

Abstracts

Topics: fetus , mice , pancreas , pregnancy trimester, first , pregnancy trimester, second

Diabetes March 2008, Vol.57, 627-634. doi:https://doi.org/10.2337/db07-0720a

Islet Studies

The Repression of IRS2 Gene by ATF3, a Stress-Inducible Gene, Contributes to Pancreatic β-Cell Apoptosis

Dan Li; Xin Yin; Erik J. Zmuda; Christopher C. Wolford; Xiaocheng Dong; Morris F. White; Tsonwin Hai

Abstracts

Topics: irs2 protein, human , stress

Diabetes March 2008, Vol.57, 635-644. doi:https://doi.org/10.2337/db07-0717

Transcription Factor 7-Like 2 Regulates β-Cell Survival and Function in Human Pancreatic Islets

Luan Shu; Nadine S. Sauter; Fabienne T. Schulthess; Aleksey V. Matveyenko; José Oberholzer; Kathrin Maedler

Abstracts

Topics: glucose , tcf7l2 gene , insulin secretion , cytokine , rna, small interfering

Diabetes March 2008, Vol.57, 645-653. doi:https://doi.org/10.2337/db07-0847

Defining Pancreatic Endocrine Precursors and Their Descendants

Peter White; Catherine Lee May; Rodrigo N. Lamounier; John E. Brestelli; Klaus H. Kaestner

Abstracts

Topics: endocrine pancreas , genes , pancreas , transcription factor , gene expression profiling

Diabetes March 2008, Vol.57, 654-668. doi:https://doi.org/10.2337/db07-1362

Pathophysiology

Postnatal Programming of Glucocorticoid Metabolism in Rats Modulates High-Fat Diet–Induced Regulation of Visceral Adipose Tissue Glucocorticoid Exposure and Sensitivity and Adiponectin and Proinflammatory Adipokines Gene Expression in Adulthood

Sandrine Boullu-Ciocca; Vincent Achard; Virginie Tassistro; Anne Dutour; Michel Grino

Abstracts

Topics: diet, high-fat , rats , adiponectin , rna, messenger , glucocorticoids

Diabetes March 2008, Vol.57, 669-677. doi:https://doi.org/10.2337/db07-1316

Predictors of Incretin Concentrations in Subjects With Normal, Impaired, and Diabetic Glucose Tolerance

Kirsten Vollmer; Jens J. Holst; Birgit Baller; Mark Ellrichmann; Michael A. Nauck; Wolfgang E. Schmidt; Juris J. Meier

Abstracts

Topics: diabetes mellitus, type 2 , glucagon-like peptide 1 , glucose , incretin , ingestion

Diabetes March 2008, Vol.57, 678-687. doi:https://doi.org/10.2337/db07-1124

The Effect of Cyclooxygenase-2 Inhibition on Renal Hemodynamic Function in Humans With Type 1 Diabetes

David Z.I. Cherney; Judith A. Miller; James W. Scholey; Timothy J. Bradley; Cameron Slorach; Jaqueline R. Curtis; Maria G. Dekker; Rania Nasrallah; Richard L. Hébert; Etienne B. Sochett

Abstracts

Topics: cyclooxygenase-2 , diabetes mellitus, type 1 , glomerular filtration rate , hyperglycemia , kidney

Diabetes March 2008, Vol.57, 688-695. doi:https://doi.org/10.2337/db07-1230

Acute Metformin Therapy Confers Cardioprotection Against Myocardial Infarction Via AMPK-eNOS–Mediated Signaling

John W. Calvert; Susheel Gundewar; Saurabh Jha; James J.M. Greer; William H. Bestermann; Rong Tian; David J. Lefer

Abstracts

Topics: ischemia , metformin , nitric oxide synthase , reperfusion therapy , ampk

Diabetes March 2008, Vol.57, 696-705. doi:https://doi.org/10.2337/db07-1098

Protein Kinase C θ Activation Induces Insulin-Mediated Constriction of Muscle Resistance Arteries

Wineke Bakker; Pieter Sipkema; Coen D.A. Stehouwer; Erik H. Serne; Yvo M. Smulders; Victor W.M. van Hinsbergh; Etto C. Eringa

Abstracts

Topics: insulin , mice , endothelin-1 , vascular constriction

Diabetes March 2008, Vol.57, 706-713. doi:https://doi.org/10.2337/db07-0792

Complications

Targeting of RhoA/ROCK Signaling Ameliorates Progression of Diabetic Nephropathy Independent of Glucose Control

Vasantha Kolavennu; Lixia Zeng; Hui Peng; Yin Wang; Farhad R. Danesh

Abstracts

Topics: diabetic nephropathy , mice , rhoa gtp-binding protein , simvastatin , kidney

Diabetes March 2008, Vol.57, 714-723. doi:https://doi.org/10.2337/db07-1241

In Vitro Hyperglycemia or a Diabetic Intrauterine Environment Reduces Neonatal Endothelial Colony-Forming Cell Numbers and Function

David A. Ingram; Izlin Z. Lien; Laura E. Mead; Myka Estes; Daniel N. Prater; Ethel Derr-Yellin; Linda A. DiMeglio; Laura S. Haneline

Abstracts

Topics: aging , endothelium , hyperglycemia , intrauterine route of drug administration , newborn

Diabetes March 2008, Vol.57, 724-731. doi:https://doi.org/10.2337/db07-1507

Delayed Recovery of Cognitive Function Following Hypoglycemia in Adults With Type 1 Diabetes : Effect of Impaired Awareness of Hypoglycemia

Nicola N. Zammitt; Roderick E. Warren; Ian J. Deary; Brian M. Frier

Abstracts

Topics: hypoglycemia , cognitive ability , diabetes mellitus, type 1 , blood glucose normal , mental processes

Diabetes March 2008, Vol.57, 732-736. doi:https://doi.org/10.2337/db07-0695

Pharmacology and Therapeutics

Therapeutic Potential of Peroxisome Proliferators–Activated Receptor-α/γ Dual Agonist With Alleviation of Endoplasmic Reticulum Stress for the Treatment of Diabetes

Kyu Lee Han; Joo Sun Choi; Jae Young Lee; Jihyun Song; Myung Kuk Joe; Myeong Ho Jung; Jae-Kwan Hwang

Abstracts

Topics: agonists , endoplasmic reticulum , insulin , liver , mice

Diabetes March 2008, Vol.57, 737-745. doi:https://doi.org/10.2337/db07-0972

Different Brain Responses to Hypoglycemia Induced by Equipotent Doses of the Long-Acting Insulin Analog Detemir and Human Regular Insulin in Humans

Paolo Rossetti; Francesca Porcellati; Natalia Busciantella Ricci; Paola Candeloro; Patrizia Cioli; Geremia B. Bolli; Carmine G. Fanelli

Abstracts

Topics: hypoglycemia , insulin , hypoglycemic agents , plasma , blood glucose normal

Diabetes March 2008, Vol.57, 746-756. doi:https://doi.org/10.2337/db07-1433

Reversal of Streptozotocin-Induced Diabetes in Mice by Cellular Transduction With Recombinant Pancreatic Transcription Factor Pancreatic Duodenal Homeobox-1 : A Novel Protein Transduction Domain–Based Therapy

Vijay Koya; Shun Lu; Yu-Ping Sun; Daniel L. Purich; Mark A. Atkinson; Shi-Wu Li; Li-Jun Yang

Abstracts

Topics: insulin , liver , mice , pancreas , streptozocin

Diabetes March 2008, Vol.57, 757-769. doi:https://doi.org/10.2337/db07-1441

Genetics

Analysis of Single Nucleotide Polymorphisms Identifies Major Type 1A Diabetes Locus Telomeric of the Major Histocompatibility Complex

Theresa A. Aly; Erin E. Baschal; Mohamed M. Jahromi; Maria S. Fernando; Sunanda R. Babu; Tasha E. Fingerlin; Adam Kretowski; Henry A. Erlich; Pamela R. Fain; Marian J. Rewers; George S. Eisenbarth

Abstracts

Topics: alleles , haplotypes , human leukocyte antigens , single nucleotide polymorphism , chromosomes

Diabetes March 2008, Vol.57, 770-776. doi:https://doi.org/10.2337/db07-0900

Genetic Variation and Association Analyses of the Nuclear Respiratory Factor 1 (nRF1) Gene in Chinese Patients With Type 2 Diabetes

Yang Liu; Nifang Niu; Xilin Zhu; Te Du; Xin Wang; Dongmei Chen; Xiaopan Wu; Harvest F. Gu; Ying Liu

Abstracts

Topics: diabetes mellitus, type 2 , fibrinogen , genes , single nucleotide polymorphism , genetics

Diabetes March 2008, Vol.57, 777-782. doi:https://doi.org/10.2337/db07-0008

Identification and Replication of a Novel Obesity Locus on Chromosome 1q24 in Isolated Populations of Cilento

Marina Ciullo; Teresa Nutile; Cyril Dalmasso; Rossella Sorice; Céline Bellenguez; Vincenza Colonna; Maria Graziella Persico; Catherine Bourgain

Abstracts

Topics: body mass index procedure , genetic linkage analysis , obesity , genetic pedigree , genome

Diabetes March 2008, Vol.57, 783-790. doi:https://doi.org/10.2337/db07-0970

Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 With Susceptibility to Type 2 Diabetes in a Japanese Population

Shintaro Omori; Yasushi Tanaka; Atsushi Takahashi; Hiroshi Hirose; Atsunori Kashiwagi; Kohei Kaku; Ryuzo Kawamori; Yusuke Nakamura; Shiro Maeda

Abstracts

Topics: diabetes mellitus, type 2 , kcnj11 gene , protein p16 , single nucleotide polymorphism , slc30a8 gene

Diabetes March 2008, Vol.57, 791-795. doi:https://doi.org/10.2337/db07-0979

Online Letters to the Editor

Comment on: Tritt et al. (2007) Functional Waning of Naturally Occurring CD4⁺ Regulatory T-cells Contributes to the Onset of Autoimmune Diabetes: Diabetes 57:113–123, 2007

David C. Thomas; Richard J. Mellanby; Anne Cooke

Extract

Topics: autoimmunity , regulatory t-lymphocytes

Diabetes March 2008, Vol.57, e6. doi:https://doi.org/10.2337/db07-1572

Response to Comment on: Tritt et al. (2007) Functional Waning of Naturally Occurring CD4⁺ Regulatory T-Cells Contributes to the Onset of Autoimmune Diabetes: Diabetes 57:113–123, 2007

Michael Tritt; Evridiki Sgouroudis; Eva d’Hennezel; Alexandre Albanese; Ciriaco A. Piccirillo

Extract