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Issues
Commentaries
Insulin Mutations in Diabetes : The Clinical Spectrum
Diabetes April 2008, Vol.57, 799-800. doi:https://doi.org/10.2337/db08-0116
Metabolism
Omentin-1, a Novel Adipokine, Is Decreased in Overweight Insulin-Resistant Women With Polycystic Ovary Syndrome : Ex Vivo and In Vivo Regulation of Omentin-1 by Insulin and Glucose
Bee K. Tan; Raghu Adya; S. Farhatullah; Kris C. Lewandowski; Paul O’Hare; Hendrik Lehnert; Harpal S. Randeva
Diabetes April 2008, Vol.57, 801-808. doi:https://doi.org/10.2337/db07-0990
PPARGC1A Variation Associated With DNA Damage, Diabetes, and Cardiovascular Diseases : The Boston Puerto Rican Health Study
Chao-Qiang Lai; Katherine L. Tucker; Laurence D. Parnell; Xian Adiconis; Bibiana García-Bailo; John Griffith; Mohsen Meydani; José M. Ordovás
Diabetes April 2008, Vol.57, 809-816. doi:https://doi.org/10.2337/db07-1238
Homocysteine Upregulates Resistin Production From Adipocytes In Vivo and In Vitro
Diabetes April 2008, Vol.57, 817-827. doi:https://doi.org/10.2337/db07-0617
Direct Administration of Insulin Into Skeletal Muscle Reveals That the Transport of Insulin Across the Capillary Endothelium Limits the Time Course of Insulin to Activate Glucose Disposal
Jenny D. Chiu; Joyce M. Richey; L. Nicole Harrison; Edward Zuniga; Cathryn M. Kolka; Erlinda Kirkman; Martin Ellmerer; Richard N. Bergman
Diabetes April 2008, Vol.57, 828-835. doi:https://doi.org/10.2337/db07-1444
Activation of Central Lactate Metabolism Lowers Glucose Production in Uncontrolled Diabetes and Diet-Induced Insulin Resistance
Diabetes April 2008, Vol.57, 836-840. doi:https://doi.org/10.2337/db07-1464
Metabolic Flexibility in Response to Glucose Is Not Impaired in People With Type 2 Diabetes After Controlling for Glucose Disposal Rate
Jose E. Galgani; Leonie K. Heilbronn; Koichiro Azuma; David E. Kelley; Jeanine B. Albu; Xavier Pi-Sunyer; Steven R. Smith; Eric Ravussin; and the Look AHEAD Adipose Research Group
Diabetes April 2008, Vol.57, 841-845. doi:https://doi.org/10.2337/db08-0043
Signal Transduction
Inhibition of Foxo1 Protects Pancreatic Islet β-Cells Against Fatty Acid and Endoplasmic Reticulum Stress–Induced Apoptosis
Sara C. Martinez; Katsuya Tanabe; Corentin Cras-Méneur; Nada A. Abumrad; Ernesto Bernal-Mizrachi; M. Alan Permutt
Diabetes April 2008, Vol.57, 846-859. doi:https://doi.org/10.2337/db07-0595
AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5
Sean L. McGee; Bryce J.W. van Denderen; Kirsten F. Howlett; Janelle Mollica; Jonathan D. Schertzer; Bruce E. Kemp; Mark Hargreaves
Diabetes April 2008, Vol.57, 860-867. doi:https://doi.org/10.2337/db07-0843
Generation of Nicotinic Acid Adenine Dinucleotide Phosphate and Cyclic ADP-Ribose by Glucagon-Like Peptide-1 Evokes Ca2+ Signal That Is Essential for Insulin Secretion in Mouse Pancreatic Islets
Byung-Ju Kim; Kwang-Hyun Park; Chang-Yeol Yim; Shin Takasawa; Hiroshi Okamoto; Mie-Jae Im; Uh-Hyun Kim
Diabetes April 2008, Vol.57, 868-878. doi:https://doi.org/10.2337/db07-0443
Proinflammatory Effects of Advanced Lipoxidation End Products in Monocytes
Narkunarajaa Shanmugam; James L. Figarola; Yan Li; Piotr M. Swiderski; Samual Rahbar; Rama Natarajan
Diabetes April 2008, Vol.57, 879-888. doi:https://doi.org/10.2337/db07-1204
Peroxynitrite Mediates Retinal Neurodegeneration by Inhibiting Nerve Growth Factor Survival Signaling in Experimental and Human Diabetes
Diabetes April 2008, Vol.57, 889-898. doi:https://doi.org/10.2337/db07-1669
Obesity Studies
Physiological and Molecular Determinants of Insulin Action in the Baboon
Alberto O. Chavez; Juan C. Lopez-Alvarenga; M. Elizabeth Tejero; Curtis Triplitt; Raul A. Bastarrachea; Apiradee Sriwijitkamol; Puntip Tantiwong; V. Saroja Voruganti; Nicolas Musi; Anthony G. Comuzzie; Ralph A. DeFronzo; Franco Folli
Diabetes April 2008, Vol.57, 899-908. doi:https://doi.org/10.2337/db07-0790
Immunology and Transplantation
B-Cells Promote Intra-Islet CD8+ Cytotoxic T-Cell Survival to Enhance Type 1 Diabetes
Diabetes April 2008, Vol.57, 909-917. doi:https://doi.org/10.2337/db07-1256
Targeting of Pancreatic Glia in Type 1 Diabetes
Hubert Tsui; Yin Chan; Lan Tang; Shawn Winer; Roy K. Cheung; Geoffrey Paltser; Thirumahal Selvanantham; Alisha R. Elford; James R. Ellis; Dorothy J. Becker; Pamela S. Ohashi; Hans-Michael Dosch
Diabetes April 2008, Vol.57, 918-928. doi:https://doi.org/10.2337/db07-0226
Association of IL-1ra and Adiponectin With C-Peptide and Remission in Patients With Type 1 Diabetes
Christian Pfleger; Henrik B. Mortensen; Lars Hansen; Christian Herder; Bart O. Roep; Hillary Hoey; Henk-Jan Aanstoot; Mirjana Kocova; Nanette C. Schloot; on behalf of the Hvidøre Study Group on Childhood Diabetes
Diabetes April 2008, Vol.57, 929-937. doi:https://doi.org/10.2337/db07-1697
Islet Studies
Thioredoxin-Interacting Protein : A Critical Link Between Glucose Toxicity and β-Cell Apoptosis
Diabetes April 2008, Vol.57, 938-944. doi:https://doi.org/10.2337/db07-0715
mTOR Inhibition by Rapamycin Prevents β-Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes
Merav Fraenkel; Mali Ketzinel-Gilad; Yafa Ariav; Orit Pappo; Melis Karaca; Julien Castel; Marie-France Berthault; Christophe Magnan; Erol Cerasi; Nurit Kaiser; Gil Leibowitz
Diabetes April 2008, Vol.57, 945-957. doi:https://doi.org/10.2337/db07-0922
Regulated β-Cell Regeneration in the Adult Mouse Pancreas
David A. Cano; Ingrid C. Rulifson; Patrick W. Heiser; Lamorna B. Swigart; Stella Pelengaris; Mike German; Gerard I. Evan; Jeffrey A. Bluestone; Matthias Hebrok
Diabetes April 2008, Vol.57, 958-966. doi:https://doi.org/10.2337/db07-0913
Obestatin Promotes Survival of Pancreatic β-Cells and Human Islets and Induces Expression of Genes Involved in the Regulation of β-Cell Mass and Function
Riccarda Granata; Fabio Settanni; Davide Gallo; Letizia Trovato; Luigi Biancone; Vincenzo Cantaluppi; Rita Nano; Marta Annunziata; Pietro Campiglia; Elisa Arnoletti; Corrado Ghè; Marco Volante; Mauro Papotti; Giampiero Muccioli; Ezio Ghigo
Diabetes April 2008, Vol.57, 967-979. doi:https://doi.org/10.2337/db07-1104
Pathophysiology
Adiponectin, Change in Adiponectin, and Progression to Diabetes in the Diabetes Prevention Program
Kieren J. Mather; Tohru Funahashi; Yuji Matsuzawa; Sharon Edelstein; George A. Bray; Steven E. Kahn; Jill Crandall; Santica Marcovina; Barry Goldstein; Ronald Goldberg; for the Diabetes Prevention Program
Diabetes April 2008, Vol.57, 980-986. doi:https://doi.org/10.2337/db07-1419
Mitochondrial Capacity in Skeletal Muscle Is Not Stimulated by Weight Loss Despite Increases in Insulin Action and Decreases in Intramyocellular Lipid Content
Frederico G.S. Toledo; Elizabeth V. Menshikova; Koichiro Azuma; Zofia Radiková; Carol A. Kelley; Vladimir B. Ritov; David E. Kelley
Diabetes April 2008, Vol.57, 987-994. doi:https://doi.org/10.2337/db07-1429
Complications
Effect of Glycemic Exposure on the Risk of Microvascular Complications in the Diabetes Control and Complications Trial—Revisited
John M. Lachin; Saul Genuth; David M. Nathan; Bernard Zinman; Brandy N. Rutledge; for the DCCT/EDIC Research Group
Diabetes April 2008, Vol.57, 995-1001. doi:https://doi.org/10.2337/db07-1618
Receptor for Advanced Glycation End Products (RAGEs) and Experimental Diabetic Neuropathy
Cory Toth; Ling Ling Rong; Christina Yang; Jose Martinez; Fei Song; Noor Ramji; Valentine Brussee; Wei Liu; Jeff Durand; Minh Dang Nguyen; Ann Marie Schmidt; Douglas W. Zochodne
Diabetes April 2008, Vol.57, 1002-1017. doi:https://doi.org/10.2337/db07-0339
ACE2 Deficiency Modifies Renoprotection Afforded by ACE Inhibition in Experimental Diabetes
Chris Tikellis; Katarzyna Bialkowski; Josepha Pete; Karen Sheehy; Qui Su; Colin Johnston; Mark E. Cooper; Merlin C. Thomas
Diabetes April 2008, Vol.57, 1018-1025. doi:https://doi.org/10.2337/db07-1212
Original Articles
Pharmacology and Therapeutics
Genetics
Insulin Mutation Screening in 1,044 Patients With Diabetes: Mutations in the INS Gene Are a Common Cause of Neonatal Diabetes but a Rare Cause of Diabetes Diagnosed in Childhood or Adulthood
Emma L. Edghill; Sarah E. Flanagan; Ann-Marie Patch; Chris Boustred; Andrew Parrish; Beverley Shields; Maggie H. Shepherd; Khalid Hussain; Ritika R. Kapoor; Maciej Malecki; Michael J. MacDonald; Julie Støy; Donald F. Steiner; Louis H. Philipson; Graeme I. Bell; the Neonatal Diabetes International Collaborative Group; Andrew T. Hattersley; Sian Ellard
Diabetes April 2008, Vol.57, 1034-1042. doi:https://doi.org/10.2337/db07-1405
A Polymorphism in the Zinc Transporter Gene SLC30A8 Confers Resistance Against Posttransplantation Diabetes Mellitus in Renal Allograft Recipients
Eun Seok Kang; Myoung Soo Kim; Yu Seun Kim; Chul Hoon Kim; Seung Jin Han; Sung Wan Chun; Kyu Yeon Hur; Chung Mo Nam; Chul Woo Ahn; Bong Soo Cha; Soon Il Kim; Hyun Chul Lee
Diabetes April 2008, Vol.57, 1043-1047. doi:https://doi.org/10.2337/db07-0761
Evidence of Interaction Between PPARG2 and HNF4A Contributing to Variation in Insulin Sensitivity in Mexican Americans
Mary Helen Black; Tasha E. Fingerlin; Hooman Allayee; Weiming Zhang; Anny H. Xiang; Enrique Trigo; Jaana Hartiala; Allison B. Lehtinen; Steven M. Haffner; Richard N. Bergman; Richard C. McEachin; Siri L. Kjos; Jean M. Lawrence; Thomas A. Buchanan; Richard M. Watanabe
Diabetes April 2008, Vol.57, 1048-1056. doi:https://doi.org/10.2337/db07-0848
Association of the Distal Region of the Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Gene With Type 2 Diabetes in an African-American Population Enriched for Nephropathy
Keith L. Keene; Josyf C. Mychaleckyj; Shelly G. Smith; Tennille S. Leak; Peter S. Perlegas; Carl D. Langefeld; Barry I. Freedman; Stephen S. Rich; Donald W. Bowden; Michèle M. Sale
Diabetes April 2008, Vol.57, 1057-1062. doi:https://doi.org/10.2337/db07-0886
The Common −866G>A Variant in the Promoter of UCP2 Is Associated With Decreased Risk of Coronary Artery Disease in Type 2 Diabetic Men
Nadir Cheurfa; Danièle Dubois-Laforgue; Daniela A.F. Ferrarezi; André F. Reis; Guilherme M. Brenner; Clara Bouché; Claude Le Feuvre; Frédéric Fumeron; José Timsit; Michel Marre; Gilberto Velho
Diabetes April 2008, Vol.57, 1063-1068. doi:https://doi.org/10.2337/db07-1292
HNF4α and the Ca-Channel TRPC1 Are Novel Disease Candidate Genes in Diabetic Nephropathy
Diabetes April 2008, Vol.57, 1069-1077. doi:https://doi.org/10.2337/db07-1065
Variations of the Perforin Gene in Patients With Type 1 Diabetes
Elisabetta Orilieri; Giuseppe Cappellano; Rita Clementi; Angela Cometa; Massimo Ferretti; Elisa Cerutti; Francesco Cadario; Miryam Martinetti; Daniela Larizza; Valeria Calcaterra; Giuseppe D’Annunzio; Renata Lorini; Franco Cerutti; Graziella Bruno; Annalisa Chiocchetti; Umberto Dianzani
Diabetes April 2008, Vol.57, 1078-1083. doi:https://doi.org/10.2337/db07-0947
HLA DR-DQ Haplotypes and Genotypes and Type 1 Diabetes Risk: Analysis of the Type 1 Diabetes Genetics Consortium Families
Henry Erlich; Ana Maria Valdes; Janelle Noble; Joyce A. Carlson; Mike Varney; Pat Concannon; Josyf C. Mychaleckyj; John A. Todd; Persia Bonella; Anna Lisa Fear; Eva Lavant; Anthony Louey; Priscilla Moonsamy; for the Type 1 Diabetes Genetics Consortium
Diabetes April 2008, Vol.57, 1084-1092. doi:https://doi.org/10.2337/db07-1331
Quantitative Trait Analysis of Type 2 Diabetes Susceptibility Loci Identified From Whole Genome Association Studies in the Insulin Resistance Atherosclerosis Family Study
Nicholette D. Palmer; Mark O. Goodarzi; Carl D. Langefeld; Julie Ziegler; Jill M. Norris; Steven M. Haffner; Michael Bryer-Ash; Richard N. Bergman; Lynne E. Wagenknecht; Kent D. Taylor; Jerome I. Rotter; Donald W. Bowden
Diabetes April 2008, Vol.57, 1093-1100. doi:https://doi.org/10.2337/db07-1169
Genetic Variants in the UCP2-UCP3 Gene Cluster and Risk of Diabetes in the Women's Health Initiative Observational Study
Diabetes April 2008, Vol.57, 1101-1107. doi:https://doi.org/10.2337/db07-1269
Association of NOS1AP Genetic Variants With QT Interval Duration in Families From the Diabetes Heart Study
Allison B. Lehtinen; Christopher Newton-Cheh; Julie T. Ziegler; Carl D. Langefeld; Barry I. Freedman; Kurt R. Daniel; David M. Herrington; Donald W. Bowden
Diabetes April 2008, Vol.57, 1108-1114. doi:https://doi.org/10.2337/db07-1365
Heterozygous Missense Mutations in the Insulin Gene Are Linked to Permanent Diabetes Appearing in the Neonatal Period or in Early Infancy: A Report From the French ND (Neonatal Diabetes) Study Group
Michel Polak; Aurélie Dechaume; Hélène Cavé; Revital Nimri; Hélène Crosnier; Véronique Sulmont; Marc de Kerdanet; Raphael Scharfmann; Yael Lebenthal; Philippe Froguel; Martine Vaxillaire
Diabetes April 2008, Vol.57, 1115-1119. doi:https://doi.org/10.2337/db07-1358
Quantitative Linkage Analysis for Pancreatic B-cell Function and Insulin Resistance in a Large Twin Cohort
Diabetes April 2008, Vol.57, 1120-1124. doi:https://doi.org/10.2337/db07-0708
The ENPP1 K121Q Polymorphism Is Associated With Type 2 Diabetes in European Populations: Evidence From an Updated Meta-Analysis in 42,042 Subjects
Jarred B. McAteer; Sabrina Prudente; Simonetta Bacci; Helen N. Lyon; Joel N. Hirschhorn; Vincenzo Trischitta; Jose C. Florez; for the ENPP1 Consortium
Diabetes April 2008, Vol.57, 1125-1130. doi:https://doi.org/10.2337/db07-1336
Mutations in the Insulin Gene Can Cause MODY and Autoantibody-Negative Type 1 Diabetes
Anders Molven; Monika Ringdal; Anita M. Nordbø; Helge Ræder; Julie Støy; Gregory M. Lipkind; Donald F. Steiner; Louis H. Philipson; Ines Bergmann; Dagfinn Aarskog; Dag E. Undlien; Geir Joner; Oddmund Søvik; the Norwegian Childhood Diabetes Study Group; Graeme I. Bell; Pål R. Njølstad
Diabetes April 2008, Vol.57, 1131-1135. doi:https://doi.org/10.2337/db07-1467
Association of Variants in the Sterol Regulatory Element-Binding Factor 1 (SREBF1) Gene With Type 2 Diabetes, Glycemia, and Insulin Resistance: A Study of 15,734 Danish Subjects
Niels Grarup; Kirstine L. Stender-Petersen; Ehm A. Andersson; Torben Jørgensen; Knut Borch-Johnsen; Annelli Sandbæk; Torsten Lauritzen; Ole Schmitz; Torben Hansen; Oluf Pedersen
Diabetes April 2008, Vol.57, 1136-1142. doi:https://doi.org/10.2337/db07-1534
A Novel Susceptibility Locus for Type 1 Diabetes on Chr12q13 Identified by a Genome-Wide Association Study
Hakon Hakonarson; Hui-Qi Qu; Jonathan P. Bradfield; Luc Marchand; Cecilia E. Kim; Joseph T. Glessner; Rosemarie Grabs; Tracy Casalunovo; Shayne P. Taback; Edward C. Frackelton; Andrew W. Eckert; Kiran Annaiah; Margaret L. Lawson; F. George Otieno; Erin Santa; Julie L. Shaner; Ryan M. Smith; Chioma C. Onyiah; Robert Skraban; Rosetta M. Chiavacci; Luke J. Robinson; Charles A. Stanley; Susan E. Kirsch; Marcella Devoto; Dimitri S. Monos; Struan F.A. Grant; Constantin Polychronakos
Diabetes April 2008, Vol.57, 1143-1146. doi:https://doi.org/10.2337/db07-1305
Genetic Variants of FTO Influence Adiposity, Insulin Sensitivity, Leptin Levels, and Resting Metabolic Rate in the Quebec Family Study
Ron Do; Swneke D. Bailey; Katia Desbiens; Alexandre Belisle; Alexandre Montpetit; Claude Bouchard; Louis Pérusse; Marie-Claude Vohl; James C. Engert
Diabetes April 2008, Vol.57, 1147-1150. doi:https://doi.org/10.2337/db07-1267
