Issues

Topics: killing , thioredoxin , glucose , stress

Diabetes April 2008, Vol.57, 797-798. doi:https://doi.org/10.2337/db08-0055

Insulin Mutations in Diabetes : The Clinical Spectrum

Benjamin Glaser

Abstracts

Topics: insulin , mutation , diabetes mellitus, type 2 , maturity onset diabetes mellitus in young

Diabetes April 2008, Vol.57, 799-800. doi:https://doi.org/10.2337/db08-0116

Metabolism

Omentin-1, a Novel Adipokine, Is Decreased in Overweight Insulin-Resistant Women With Polycystic Ovary Syndrome : Ex Vivo and In Vivo Regulation of Omentin-1 by Insulin and Glucose

Bee K. Tan; Raghu Adya; S. Farhatullah; Kris C. Lewandowski; Paul O’Hare; Hendrik Lehnert; Harpal S. Randeva

Abstracts

Topics: adipose tissue , glucose , insulin , omentum , polycystic ovary syndrome

Diabetes April 2008, Vol.57, 801-808. doi:https://doi.org/10.2337/db07-0990

PPARGC1A Variation Associated With DNA Damage, Diabetes, and Cardiovascular Diseases : The Boston Puerto Rican Health Study

Chao-Qiang Lai; Katherine L. Tucker; Laurence D. Parnell; Xian Adiconis; Bibiana García-Bailo; John Griffith; Mohsen Meydani; José M. Ordovás

Abstracts

Topics: cardiovascular diseases , diabetes mellitus, type 2 , dna damage , single nucleotide polymorphism , haplotypes

Diabetes April 2008, Vol.57, 809-816. doi:https://doi.org/10.2337/db07-1238

Homocysteine Upregulates Resistin Production From Adipocytes In Vivo and In Vitro

Yin Li; Changtao Jiang; Guoheng Xu; Nanping Wang; Yi Zhu; Chaoshu Tang; Xian Wang

Abstracts

Topics: adipocytes , insulin resistance , resistin , insulin , mice

Diabetes April 2008, Vol.57, 817-827. doi:https://doi.org/10.2337/db07-0617

Direct Administration of Insulin Into Skeletal Muscle Reveals That the Transport of Insulin Across the Capillary Endothelium Limits the Time Course of Insulin to Activate Glucose Disposal

Jenny D. Chiu; Joyce M. Richey; L. Nicole Harrison; Edward Zuniga; Cathryn M. Kolka; Erlinda Kirkman; Martin Ellmerer; Richard N. Bergman

Abstracts

Topics: insulin , glucose , lymph

Diabetes April 2008, Vol.57, 828-835. doi:https://doi.org/10.2337/db07-1444

Activation of Central Lactate Metabolism Lowers Glucose Production in Uncontrolled Diabetes and Diet-Induced Insulin Resistance

Madhu Chari; Carol K.L. Lam; Penny Y.T. Wang; Tony K.T. Lam

Abstracts

Topics: diet , glucose , insulin , insulin resistance , lactates

Diabetes April 2008, Vol.57, 836-840. doi:https://doi.org/10.2337/db07-1464

Metabolic Flexibility in Response to Glucose Is Not Impaired in People With Type 2 Diabetes After Controlling for Glucose Disposal Rate

Jose E. Galgani; Leonie K. Heilbronn; Koichiro Azuma; David E. Kelley; Jeanine B. Albu; Xavier Pi-Sunyer; Steven R. Smith; Eric Ravussin; and the Look AHEAD Adipose Research Group

Abstracts

Topics: glucose , diabetes mellitus, type 2 , insulin , weight reduction

Diabetes April 2008, Vol.57, 841-845. doi:https://doi.org/10.2337/db08-0043

Signal Transduction

Inhibition of Foxo1 Protects Pancreatic Islet β-Cells Against Fatty Acid and Endoplasmic Reticulum Stress–Induced Apoptosis

Sara C. Martinez; Katsuya Tanabe; Corentin Cras-Méneur; Nada A. Abumrad; Ernesto Bernal-Mizrachi; M. Alan Permutt

Abstracts

Topics: apoptosis , fatty acids , forkhead box protein o1 , palmitates , stress

Diabetes April 2008, Vol.57, 846-859. doi:https://doi.org/10.2337/db07-0595

AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5

Sean L. McGee; Bryce J.W. van Denderen; Kirsten F. Howlett; Janelle Mollica; Jonathan D. Schertzer; Bruce E. Kemp; Mark Hargreaves

Abstracts

Topics: aica ribonucleotide , ampk , chromatin immunoprecipitation , genes , histone deacetylase

Diabetes April 2008, Vol.57, 860-867. doi:https://doi.org/10.2337/db07-0843

Generation of Nicotinic Acid Adenine Dinucleotide Phosphate and Cyclic ADP-Ribose by Glucagon-Like Peptide-1 Evokes Ca²⁺ Signal That Is Essential for Insulin Secretion in Mouse Pancreatic Islets

Byung-Ju Kim; Kwang-Hyun Park; Chang-Yeol Yim; Shin Takasawa; Hiroshi Okamoto; Mie-Jae Im; Uh-Hyun Kim

Abstracts

Topics: glucagon-like peptide 1 , glucose , organelles , insulin secretion , cd38

Diabetes April 2008, Vol.57, 868-878. doi:https://doi.org/10.2337/db07-0443

Proinflammatory Effects of Advanced Lipoxidation End Products in Monocytes

Narkunarajaa Shanmugam; James L. Figarola; Yan Li; Piotr M. Swiderski; Samual Rahbar; Rama Natarajan

Abstracts

Topics: chemokines , monocytes , thp-1 cells , genes , adhesions

Diabetes April 2008, Vol.57, 879-888. doi:https://doi.org/10.2337/db07-1204

Peroxynitrite Mediates Retinal Neurodegeneration by Inhibiting Nerve Growth Factor Survival Signaling in Experimental and Human Diabetes

Tayyeba K. Ali; Suraporn Matragoon; Bindu A. Pillai; Gregory I. Liou; Azza B. El-Remessy

Abstracts

Topics: peroxynitrite , retina , tyrosine

Diabetes April 2008, Vol.57, 889-898. doi:https://doi.org/10.2337/db07-1669

Obesity Studies

Physiological and Molecular Determinants of Insulin Action in the Baboon

Alberto O. Chavez; Juan C. Lopez-Alvarenga; M. Elizabeth Tejero; Curtis Triplitt; Raul A. Bastarrachea; Apiradee Sriwijitkamol; Puntip Tantiwong; V. Saroja Voruganti; Nicolas Musi; Anthony G. Comuzzie; Ralph A. DeFronzo; Franco Folli

Abstracts

Topics: insulin , papio , obesity

Diabetes April 2008, Vol.57, 899-908. doi:https://doi.org/10.2337/db07-0790

Immunology and Transplantation

B-Cells Promote Intra-Islet CD8⁺ Cytotoxic T-Cell Survival to Enhance Type 1 Diabetes

Gillian M. Brodie; Maja Wallberg; Pere Santamaria; F. Susan Wong; E. Allison Green

Abstracts

Topics: b-lymphocytes , diabetes mellitus, type 1 , mice , t-lymphocytes , inflammation

Diabetes April 2008, Vol.57, 909-917. doi:https://doi.org/10.2337/db07-1256

Targeting of Pancreatic Glia in Type 1 Diabetes

Hubert Tsui; Yin Chan; Lan Tang; Shawn Winer; Roy K. Cheung; Geoffrey Paltser; Thirumahal Selvanantham; Alisha R. Elford; James R. Ellis; Dorothy J. Becker; Pamela S. Ohashi; Hans-Michael Dosch

Abstracts

Topics: codon, nonsense , diabetes mellitus, type 1 , epitopes , glial fibrillary acidic protein , peptides

Diabetes April 2008, Vol.57, 918-928. doi:https://doi.org/10.2337/db07-0226

Association of IL-1ra and Adiponectin With C-Peptide and Remission in Patients With Type 1 Diabetes

Christian Pfleger; Henrik B. Mortensen; Lars Hansen; Christian Herder; Bart O. Roep; Hillary Hoey; Henk-Jan Aanstoot; Mirjana Kocova; Nanette C. Schloot; on behalf of the Hvidøre Study Group on Childhood Diabetes

Abstracts

Topics: adiponectin , c-peptide , cytokine , disease remission , diabetes mellitus, type 1

Diabetes April 2008, Vol.57, 929-937. doi:https://doi.org/10.2337/db07-1697

Islet Studies

Thioredoxin-Interacting Protein : A Critical Link Between Glucose Toxicity and β-Cell Apoptosis

Junqin Chen; Geetu Saxena; Imran N. Mungrue; Aldons J. Lusis; Anath Shalev

Abstracts

Topics: apoptosis , glucose , toxic effect , caspase-3 , mice

Diabetes April 2008, Vol.57, 938-944. doi:https://doi.org/10.2337/db07-0715

mTOR Inhibition by Rapamycin Prevents β-Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes

Merav Fraenkel; Mali Ketzinel-Gilad; Yafa Ariav; Orit Pappo; Melis Karaca; Julien Castel; Marie-France Berthault; Christophe Magnan; Erol Cerasi; Nurit Kaiser; Gil Leibowitz

Abstracts

Topics: rapamycin , insulin , blood glucose normal , mtor serine-threonine kinases

Diabetes April 2008, Vol.57, 945-957. doi:https://doi.org/10.2337/db07-0922

Regulated β-Cell Regeneration in the Adult Mouse Pancreas

David A. Cano; Ingrid C. Rulifson; Patrick W. Heiser; Lamorna B. Swigart; Stella Pelengaris; Mike German; Gerard I. Evan; Jeffrey A. Bluestone; Matthias Hebrok

Abstracts

Topics: bone nails , c-myc genes , insulin , mice , mice, transgenic

Diabetes April 2008, Vol.57, 958-966. doi:https://doi.org/10.2337/db07-0913

Obestatin Promotes Survival of Pancreatic β-Cells and Human Islets and Induces Expression of Genes Involved in the Regulation of β-Cell Mass and Function

Riccarda Granata; Fabio Settanni; Davide Gallo; Letizia Trovato; Luigi Biancone; Vincenzo Cantaluppi; Rita Nano; Marta Annunziata; Pietro Campiglia; Elisa Arnoletti; Corrado Ghè; Marco Volante; Mauro Papotti; Giampiero Muccioli; Ezio Ghigo

Abstracts

Topics: obestatin

Diabetes April 2008, Vol.57, 967-979. doi:https://doi.org/10.2337/db07-1104

Pathophysiology

Adiponectin, Change in Adiponectin, and Progression to Diabetes in the Diabetes Prevention Program

Kieren J. Mather; Tohru Funahashi; Yuji Matsuzawa; Sharon Edelstein; George A. Bray; Steven E. Kahn; Jill Crandall; Santica Marcovina; Barry Goldstein; Ronald Goldberg; for the Diabetes Prevention Program

Abstracts

Topics: adiponectin , diabetes prevention

Diabetes April 2008, Vol.57, 980-986. doi:https://doi.org/10.2337/db07-1419

Mitochondrial Capacity in Skeletal Muscle Is Not Stimulated by Weight Loss Despite Increases in Insulin Action and Decreases in Intramyocellular Lipid Content

Frederico G.S. Toledo; Elizabeth V. Menshikova; Koichiro Azuma; Zofia Radiková; Carol A. Kelley; Vladimir B. Ritov; David E. Kelley

Abstracts

Topics: diet , dna, mitochondrial , insulin , insulin resistance , lipids

Diabetes April 2008, Vol.57, 987-994. doi:https://doi.org/10.2337/db07-1429

Complications

Effect of Glycemic Exposure on the Risk of Microvascular Complications in the Diabetes Control and Complications Trial—Revisited

John M. Lachin; Saul Genuth; David M. Nathan; Bernard Zinman; Brandy N. Rutledge; for the DCCT/EDIC Research Group

Abstracts

Topics: dcct trial , retinal diseases

Diabetes April 2008, Vol.57, 995-1001. doi:https://doi.org/10.2337/db07-1618

Receptor for Advanced Glycation End Products (RAGEs) and Experimental Diabetic Neuropathy

Cory Toth; Ling Ling Rong; Christina Yang; Jose Martinez; Fei Song; Noor Ramji; Valentine Brussee; Wei Liu; Jeff Durand; Minh Dang Nguyen; Ann Marie Schmidt; Douglas W. Zochodne

Abstracts

Topics: diabetic neuropathies , ganglia, spinal , mice , rage , neurons

Diabetes April 2008, Vol.57, 1002-1017. doi:https://doi.org/10.2337/db07-0339

ACE2 Deficiency Modifies Renoprotection Afforded by ACE Inhibition in Experimental Diabetes

Chris Tikellis; Katarzyna Bialkowski; Josepha Pete; Karen Sheehy; Qui Su; Colin Johnston; Mark E. Cooper; Merlin C. Thomas

Abstracts

Topics: angiotensin-converting enzyme inhibitors , diabetes mellitus, experimental , hypertrophy , kidney , mice

Diabetes April 2008, Vol.57, 1018-1025. doi:https://doi.org/10.2337/db07-1212

Original Articles

Pharmacology and Therapeutics

Intravitreal Triamcinolone Acetonide Inhibits Breakdown of the Blood-Retinal Barrier Through Differential Regulation of VEGF-A and Its Receptors in Early Diabetic Rat Retinas

Xinyuan Zhang; Shisan Bao; Donna Lai; Robert W. Rapkins; Mark C. Gillies

Abstracts

Topics: albumins , retina , vascular endothelial growth factor a , vegfr-1 , immunohistochemistry

Diabetes January 2008, Vol.57, 1026-1033. doi:https://doi.org/10.2337/db07-0982

Genetics

Insulin Mutation Screening in 1,044 Patients With Diabetes: Mutations in the INS Gene Are a Common Cause of Neonatal Diabetes but a Rare Cause of Diabetes Diagnosed in Childhood or Adulthood

Emma L. Edghill; Sarah E. Flanagan; Ann-Marie Patch; Chris Boustred; Andrew Parrish; Beverley Shields; Maggie H. Shepherd; Khalid Hussain; Ritika R. Kapoor; Maciej Malecki; Michael J. MacDonald; Julie Støy; Donald F. Steiner; Louis H. Philipson; Graeme I. Bell; the Neonatal Diabetes International Collaborative Group; Andrew T. Hattersley; Sian Ellard

Abstracts

Topics: mutation , maturity onset diabetes mellitus in young , neonatal diabetes mellitus , insulin

Diabetes April 2008, Vol.57, 1034-1042. doi:https://doi.org/10.2337/db07-1405

A Polymorphism in the Zinc Transporter Gene SLC30A8 Confers Resistance Against Posttransplantation Diabetes Mellitus in Renal Allograft Recipients

Eun Seok Kang; Myoung Soo Kim; Yu Seun Kim; Chul Hoon Kim; Seung Jin Han; Sung Wan Chun; Kyu Yeon Hur; Chung Mo Nam; Chul Woo Ahn; Bong Soo Cha; Soon Il Kim; Hyun Chul Lee

Abstracts

Topics: allografting , genes , genotype , immunosuppressive agents , insulin

Diabetes April 2008, Vol.57, 1043-1047. doi:https://doi.org/10.2337/db07-0761

Evidence of Interaction Between PPARG2 and HNF4A Contributing to Variation in Insulin Sensitivity in Mexican Americans

Mary Helen Black; Tasha E. Fingerlin; Hooman Allayee; Weiming Zhang; Anny H. Xiang; Enrique Trigo; Jaana Hartiala; Allison B. Lehtinen; Steven M. Haffner; Richard N. Bergman; Richard C. McEachin; Siri L. Kjos; Jean M. Lawrence; Thomas A. Buchanan; Richard M. Watanabe

Abstracts

Topics: alleles , diabetes mellitus, type 2 , genotype , hnf4a gene , insulin

Diabetes April 2008, Vol.57, 1048-1056. doi:https://doi.org/10.2337/db07-0848

Association of the Distal Region of the Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Gene With Type 2 Diabetes in an African-American Population Enriched for Nephropathy

Keith L. Keene; Josyf C. Mychaleckyj; Shelly G. Smith; Tennille S. Leak; Peter S. Perlegas; Carl D. Langefeld; Barry I. Freedman; Stephen S. Rich; Donald W. Bowden; Michèle M. Sale

Abstracts

Topics: diabetes mellitus, type 2 , genes , genotype determination , kidney diseases , kidney failure, chronic

Diabetes April 2008, Vol.57, 1057-1062. doi:https://doi.org/10.2337/db07-0886

The Common −866G>A Variant in the Promoter of UCP2 Is Associated With Decreased Risk of Coronary Artery Disease in Type 2 Diabetic Men

Nadir Cheurfa; Danièle Dubois-Laforgue; Daniela A.F. Ferrarezi; André F. Reis; Guilherme M. Brenner; Clara Bouché; Claude Le Feuvre; Frédéric Fumeron; José Timsit; Michel Marre; Gilberto Velho

Abstracts

Topics: alleles , coronary arteriosclerosis , coronary artery bypass surgery , hypertension , myocardial infarction

Diabetes April 2008, Vol.57, 1063-1068. doi:https://doi.org/10.2337/db07-1292

HNF4α and the Ca-Channel TRPC1 Are Novel Disease Candidate Genes in Diabetic Nephropathy

Monika Niehof; Jürgen Borlak

Abstracts

Topics: caco-2 cells , candidate disease gene , cloning , diabetic nephropathy , electrophoretic mobility shift assay

Diabetes April 2008, Vol.57, 1069-1077. doi:https://doi.org/10.2337/db07-1065

Variations of the Perforin Gene in Patients With Type 1 Diabetes

Elisabetta Orilieri; Giuseppe Cappellano; Rita Clementi; Angela Cometa; Massimo Ferretti; Elisa Cerutti; Francesco Cadario; Miryam Martinetti; Daniela Larizza; Valeria Calcaterra; Giuseppe D’Annunzio; Renata Lorini; Franco Cerutti; Graziella Bruno; Annalisa Chiocchetti; Umberto Dianzani

Abstracts

Topics: autoimmune lymphoproliferative syndrome , diabetes mellitus, type 1 , genes , perforin , mutation

Diabetes April 2008, Vol.57, 1078-1083. doi:https://doi.org/10.2337/db07-0947

HLA DR-DQ Haplotypes and Genotypes and Type 1 Diabetes Risk: Analysis of the Type 1 Diabetes Genetics Consortium Families

Henry Erlich; Ana Maria Valdes; Janelle Noble; Joyce A. Carlson; Mike Varney; Pat Concannon; Josyf C. Mychaleckyj; John A. Todd; Persia Bonella; Anna Lisa Fear; Eva Lavant; Anthony Louey; Priscilla Moonsamy; for the Type 1 Diabetes Genetics Consortium

Abstracts

Topics: diabetes mellitus, type 1 , genotype , haplotypes , human leukocyte antigens , alleles

Diabetes April 2008, Vol.57, 1084-1092. doi:https://doi.org/10.2337/db07-1331

Quantitative Trait Analysis of Type 2 Diabetes Susceptibility Loci Identified From Whole Genome Association Studies in the Insulin Resistance Atherosclerosis Family Study

Nicholette D. Palmer; Mark O. Goodarzi; Carl D. Langefeld; Julie Ziegler; Jill M. Norris; Steven M. Haffner; Michael Bryer-Ash; Richard N. Bergman; Lynne E. Wagenknecht; Kent D. Taylor; Jerome I. Rotter; Donald W. Bowden

Abstracts

Topics: atherosclerosis , diabetes mellitus, type 2 , family studies , genome-wide association study , insulin resistance

Diabetes April 2008, Vol.57, 1093-1100. doi:https://doi.org/10.2337/db07-1169

Genetic Variants in the UCP2-UCP3 Gene Cluster and Risk of Diabetes in the Women's Health Initiative Observational Study

Yi-Hsiang Hsu; Tianhua Niu; Yiqing Song; Lesley Tinker; Lewis H. Kuller; Simin Liu

Abstracts

Topics: diabetes mellitus, type 2 , gene clusters , genetics , haplotypes , observational studies

Diabetes April 2008, Vol.57, 1101-1107. doi:https://doi.org/10.2337/db07-1269

Association of NOS1AP Genetic Variants With QT Interval Duration in Families From the Diabetes Heart Study

Allison B. Lehtinen; Christopher Newton-Cheh; Julie T. Ziegler; Carl D. Langefeld; Barry I. Freedman; Kurt R. Daniel; David M. Herrington; Donald W. Bowden

Abstracts

Topics: nos1ap gene , qt interval , genetics , heart , single nucleotide polymorphism

Diabetes April 2008, Vol.57, 1108-1114. doi:https://doi.org/10.2337/db07-1365

Heterozygous Missense Mutations in the Insulin Gene Are Linked to Permanent Diabetes Appearing in the Neonatal Period or in Early Infancy: A Report From the French ND (Neonatal Diabetes) Study Group

Michel Polak; Aurélie Dechaume; Hélène Cavé; Revital Nimri; Hélène Crosnier; Véronique Sulmont; Marc de Kerdanet; Raphael Scharfmann; Yael Lebenthal; Philippe Froguel; Martine Vaxillaire

Abstracts

Topics: genes , heterozygote , infant , insulin , missense mutation

Diabetes April 2008, Vol.57, 1115-1119. doi:https://doi.org/10.2337/db07-1358

Quantitative Linkage Analysis for Pancreatic B-cell Function and Insulin Resistance in a Large Twin Cohort

Mario Falchi; Scott G. Wilson; Dimitrios Paximadas; Ramasamyiyer Swaminathan; Tim D. Spector

Abstracts

Topics: genetic linkage analysis , genotype determination , glucose , insulin , insulin resistance

Diabetes April 2008, Vol.57, 1120-1124. doi:https://doi.org/10.2337/db07-0708

The ENPP1 K121Q Polymorphism Is Associated With Type 2 Diabetes in European Populations: Evidence From an Updated Meta-Analysis in 42,042 Subjects

Jarred B. McAteer; Sabrina Prudente; Simonetta Bacci; Helen N. Lyon; Joel N. Hirschhorn; Vincenzo Trischitta; Jose C. Florez; for the ENPP1 Consortium

Abstracts

Topics: diabetes mellitus, type 2 , heterogeneity , polymorphism

Diabetes April 2008, Vol.57, 1125-1130. doi:https://doi.org/10.2337/db07-1336

Mutations in the Insulin Gene Can Cause MODY and Autoantibody-Negative Type 1 Diabetes

Anders Molven; Monika Ringdal; Anita M. Nordbø; Helge Ræder; Julie Støy; Gregory M. Lipkind; Donald F. Steiner; Louis H. Philipson; Ines Bergmann; Dagfinn Aarskog; Dag E. Undlien; Geir Joner; Oddmund Søvik; the Norwegian Childhood Diabetes Study Group; Graeme I. Bell; Pål R. Njølstad

Abstracts

Topics: autoantibodies , diabetes mellitus, type 1 , insulin , maturity onset diabetes mellitus in young , mutation

Diabetes April 2008, Vol.57, 1131-1135. doi:https://doi.org/10.2337/db07-1467

Association of Variants in the Sterol Regulatory Element-Binding Factor 1 (SREBF1) Gene With Type 2 Diabetes, Glycemia, and Insulin Resistance: A Study of 15,734 Danish Subjects

Niels Grarup; Kirstine L. Stender-Petersen; Ehm A. Andersson; Torben Jørgensen; Knut Borch-Johnsen; Annelli Sandbæk; Torsten Lauritzen; Ole Schmitz; Torben Hansen; Oluf Pedersen

Abstracts

Topics: diabetes mellitus, type 2 , sterols , genes , insulin resistance , fibrinogen

Diabetes April 2008, Vol.57, 1136-1142. doi:https://doi.org/10.2337/db07-1534

A Novel Susceptibility Locus for Type 1 Diabetes on Chr12q13 Identified by a Genome-Wide Association Study

Abstracts

Topics: diabetes mellitus, type 1 , single nucleotide polymorphism , genotype determination , genome-wide association study

Diabetes April 2008, Vol.57, 1143-1146. doi:https://doi.org/10.2337/db07-1305

Genetic Variants of FTO Influence Adiposity, Insulin Sensitivity, Leptin Levels, and Resting Metabolic Rate in the Quebec Family Study

Ron Do; Swneke D. Bailey; Katia Desbiens; Alexandre Belisle; Alexandre Montpetit; Claude Bouchard; Louis Pérusse; Marie-Claude Vohl; James C. Engert

Abstracts