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Issues
Perspectives in Diabetes
From Fibrosis to Sclerosis: Mechanisms of Glomerulosclerosis in Diabetic Nephropathy
Diabetes June 2008, Vol.57, 1439-1445. doi:https://doi.org/10.2337/db08-0061
Oxidative Stress as a Major Culprit in Kidney Disease in Diabetes
Diabetes June 2008, Vol.57, 1446-1454. doi:https://doi.org/10.2337/db08-0057
Commentaries
Fatty Acid Oxidation and Insulin Action: When Less Is More
Diabetes June 2008, Vol.57, 1455-1456. doi:https://doi.org/10.2337/db08-0281
Dedifferentiation for Replication of Human β-Cells: A Division Between Mice and Men?
Diabetes June 2008, Vol.57, 1457-1458. doi:https://doi.org/10.2337/db08-0364
HNF4A and Diabetes: Injury Before Insult?
Diabetes June 2008, Vol.57, 1461-1462. doi:https://doi.org/10.2337/db08-0454
Metabolism
Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice
Patrice D. Cani; Rodrigo Bibiloni; Claude Knauf; Aurélie Waget; Audrey M. Neyrinck; Nathalie M. Delzenne; Rémy Burcelin
Diabetes June 2008, Vol.57, 1470-1481. doi:https://doi.org/10.2337/db07-1403
Central Nervous System Neuropeptide Y Signaling Modulates VLDL Triglyceride Secretion
Diabetes June 2008, Vol.57, 1482-1490. doi:https://doi.org/10.2337/db07-1702
Kinin B1 Receptor Deficiency Leads to Leptin Hypersensitivity and Resistance to Obesity
Marcelo A. Mori; Ronaldo C. Araújo; Felipe C.G. Reis; Daniela G. Sgai; Raphael G. Fonseca; Carlos C. Barros; Vanessa F. Merino; Mariana Passadore; Ana M. Barbosa; Bernard Ferrari; Pierre Carayon; Charlles H.M. Castro; Suma I. Shimuta; Jacqueline Luz; Jean-Loup Bascands; Joost P. Schanstra; Patrick C. Even; Suzana M. Oliveira; Michael Bader; João B. Pesquero
Diabetes June 2008, Vol.57, 1491-1500. doi:https://doi.org/10.2337/db07-1508
Metformin Decreases the Adipokine Vaspin in Overweight Women With Polycystic Ovary Syndrome Concomitant With Improvement in Insulin Sensitivity and a Decrease in Insulin Resistance
Bee K. Tan; Dennis Heutling; Jing Chen; S. Farhatullah; Raghu Adya; Stephen D. Keay; C. Richard Kennedy; Hendrik Lehnert; Harpal S. Randeva
Diabetes June 2008, Vol.57, 1501-1507. doi:https://doi.org/10.2337/db08-0127
Malonyl CoenzymeA Decarboxylase Regulates Lipid and Glucose Metabolism in Human Skeletal Muscle
Karim Bouzakri; Reginald Austin; Anna Rune; Michael E. Lassman; Pablo M. Garcia-Roves; Joel P. Berger; Anna Krook; Alexander V. Chibalin; Bei B. Zhang; Juleen R. Zierath
Diabetes June 2008, Vol.57, 1508-1516. doi:https://doi.org/10.2337/db07-0583
Obesity Studies
Transgenic Mice Overexpressing Neuropeptide Y in Noradrenergic Neurons: A Novel Model of Increased Adiposity and Impaired Glucose Tolerance
Suvi T. Ruohonen; Ullamari Pesonen; Niko Moritz; Katja Kaipio; Matias Röyttä; Markku Koulu; Eriika Savontaus
Diabetes June 2008, Vol.57, 1517-1525. doi:https://doi.org/10.2337/db07-0722
Treatment of Obese Diabetic Mice With a Heme Oxygenase Inducer Reduces Visceral and Subcutaneous Adiposity, Increases Adiponectin Levels, and Improves Insulin Sensitivity and Glucose Tolerance
Ming Li; Dong Hyun Kim; Peter L. Tsenovoy; Stephen J. Peterson; Rita Rezzani; Luigi F. Rodella; Wilbert S. Aronow; Susumu Ikehara; Nader G. Abraham
Diabetes June 2008, Vol.57, 1526-1535. doi:https://doi.org/10.2337/db07-1764
Reduced Glucocorticoid Production Rate, Decreased 5α-Reductase Activity, and Adipose Tissue Insulin Sensitization After Weight Loss
Diabetes June 2008, Vol.57, 1536-1543. doi:https://doi.org/10.2337/db08-0094
Immunology and Transplantation
A Microsphere-Based Vaccine Prevents and Reverses New-Onset Autoimmune Diabetes
Brett Phillips; Karen Nylander; Jo Harnaha; Jennifer Machen; Robert Lakomy; Alexis Styche; Kimberly Gillis; Larry Brown; Debra Lafreniere; Michael Gallo; Janet Knox; Kenneth Hogeland; Massimo Trucco; Nick Giannoukakis
Diabetes June 2008, Vol.57, 1544-1555. doi:https://doi.org/10.2337/db07-0507
The Caspase Selective Inhibitor EP1013 Augments Human Islet Graft Function and Longevity in Marginal Mass Islet Transplantation in Mice
Juliet A. Emamaullee; Joy Davis; Rena Pawlick; Christian Toso; Shaheed Merani; Sui-Xiong Cai; Ben Tseng; A.M. James Shapiro
Diabetes June 2008, Vol.57, 1556-1566. doi:https://doi.org/10.2337/db07-1452
Intrahepatic Glucose Flux as a Mechanism for Defective Intrahepatic Islet α-Cell Response to Hypoglycemia
Huarong Zhou; Tao Zhang; Marika Bogdani; Elizabeth Oseid; Susan Parazzoli; Marie-Christine Vantyghem; Jamie Harmon; Michela Slucca; R. Paul Robertson
Diabetes June 2008, Vol.57, 1567-1574. doi:https://doi.org/10.2337/db08-0137
Islet Studies
In Vitro Proliferation of Cells Derived From Adult Human β-Cells Revealed By Cell-Lineage Tracing
Diabetes June 2008, Vol.57, 1575-1583. doi:https://doi.org/10.2337/db07-1283
β-Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of β-Cell Mass in Humans
Juris J. Meier; Alexandra E. Butler; Yoshifumi Saisho; Travis Monchamp; Ryan Galasso; Anil Bhushan; Robert A. Rizza; Peter C. Butler
Diabetes June 2008, Vol.57, 1584-1594. doi:https://doi.org/10.2337/db07-1369
A Rare Mutation in ABCC8/SUR1 Leading to Altered ATP-Sensitive K+ Channel Activity and β-Cell Glucose Sensing Is Associated With Type 2 Diabetes in Adults
Andrei I. Tarasov; Tamara J. Nicolson; Jean-Pierre Riveline; Tarvinder K. Taneja; Stephen A. Baldwin; Jocelyn M. Baldwin; Guillaume Charpentier; Jean-François Gautier; Philippe Froguel; Martine Vaxillaire; Guy A. Rutter
Diabetes June 2008, Vol.57, 1595-1604. doi:https://doi.org/10.2337/db07-1547
Voltage-Gated Ion Channels in Human Pancreatic β-Cells: Electrophysiological Characterization and Role in Insulin Secretion
Matthias Braun; Reshma Ramracheya; Martin Bengtsson; Quan Zhang; Jovita Karanauskaite; Chris Partridge; Paul R. Johnson; Patrik Rorsman
Diabetes June 2008, Vol.57, 1618-1628. doi:https://doi.org/10.2337/db07-0991
Pathophysiology
Retinal and Cerebral Microvascular Signs and Diabetes: The Age, Gene/Environment Susceptibility-Reykjavik Study
Chengxuan Qiu; Mary Frances Cotch; Sigurdur Sigurdsson; Melissa Garcia; Ronald Klein; Fridbert Jonasson; Barbara E.K. Klein; Gudny Eiriksdottir; Tamara B. Harris; Mark A. van Buchem; Vilmundur Gudnason; Lenore J. Launer
Diabetes June 2008, Vol.57, 1645-1650. doi:https://doi.org/10.2337/db07-1455
Suppressors of Cytokine-Signaling Proteins Induce Insulin Resistance in the Retina and Promote Survival of Retinal Cells
Xuebin Liu; Marie G. Mameza; Yun Sang Lee; Chikezie I. Eseonu; Cheng-Rong Yu; Jennifer J. Kang Derwent; Charles E. Egwuagu
Diabetes June 2008, Vol.57, 1651-1658. doi:https://doi.org/10.2337/db07-1761
Persistent Hyperinsulinemic Hypoglycemia and Maturity-Onset Diabetes of the Young Due to Heterozygous HNF4A Mutations
Ritika R. Kapoor; Jonathan Locke; Kevin Colclough; Jerry Wales; Jennifer J. Conn; Andrew T. Hattersley; Sian Ellard; Khalid Hussain
Diabetes June 2008, Vol.57, 1659-1663. doi:https://doi.org/10.2337/db07-1657
Complications
Distal Degenerative Sensory Neuropathy in a Long-Term Type 2 Diabetes Rat Model
Valentine Brussee; GuiFang Guo; YingYing Dong; Chu Cheng; José A. Martinez; Darrell Smith; Gordon W. Glazner; Paul Fernyhough; Douglas W. Zochodne
Diabetes June 2008, Vol.57, 1664-1673. doi:https://doi.org/10.2337/db07-1737
Decreased Lipoprotein Clearance Is Responsible for Increased Cholesterol in LDL Receptor Knockout Mice With Streptozotocin-Induced Diabetes
Ira J. Goldberg; Yunying Hu; Hye-Lim Noh; Justin Wei; Lesley Ann Huggins; Marnie G. Rackmill; Hiroko Hamai; Brendan N. Reid; William S. Blaner; Li-Shin Huang
Diabetes June 2008, Vol.57, 1674-1682. doi:https://doi.org/10.2337/db08-0083
RhoA/Rho-Kinase Contribute to the Pathogenesis of Diabetic Renal Disease
Fangfang Peng; Dongcheng Wu; Bo Gao; Alistair J. Ingram; Baifang Zhang; Katherine Chorneyko; Rick McKenzie; Joan C. Krepinsky
Diabetes June 2008, Vol.57, 1683-1692. doi:https://doi.org/10.2337/db07-1149
Abnormal Muscle Spindle Innervation and Large-Fiber Neuropathy in Diabetic Mice
Diabetes June 2008, Vol.57, 1693-1701. doi:https://doi.org/10.2337/db08-0022
Haptoglobin Genotype: A Determinant of Cardiovascular Complication Risk in Type 1 Diabetes
Diabetes June 2008, Vol.57, 1702-1706. doi:https://doi.org/10.2337/db08-0095
Having One Kidney Does Not Accelerate the Rate of Development of Diabetic Nephropathy Lesions in Type 1 Diabetic Patients
Diabetes June 2008, Vol.57, 1707-1711. doi:https://doi.org/10.2337/db07-1610
Urinary Smad1 Is a Novel Marker to Predict Later Onset of Mesangial Matrix Expansion in Diabetic Nephropathy
Akira Mima; Hidenori Arai; Takeshi Matsubara; Hideharu Abe; Kojiro Nagai; Yukinori Tamura; Kazuo Torikoshi; Makoto Araki; Hiroshi Kanamori; Toshikazu Takahashi; Tatsuya Tominaga; Motokazu Matsuura; Noriyuki Iehara; Atsushi Fukatsu; Toru Kita; Toshio Doi
Diabetes June 2008, Vol.57, 1712-1722. doi:https://doi.org/10.2337/db07-1726
Pharmacology and Therapeutics
Dapagliflozin, a Selective SGLT2 Inhibitor, Improves Glucose Homeostasis in Normal and Diabetic Rats
Songping Han; Deborah L. Hagan; Joseph R. Taylor; Li Xin; Wei Meng; Scott A. Biller; John R. Wetterau; William N. Washburn; Jean M. Whaley
Diabetes June 2008, Vol.57, 1723-1729. doi:https://doi.org/10.2337/db07-1472
Genetics
PTPN22 Trp620 Explains the Association of Chromosome 1p13 With Type 1 Diabetes and Shows a Statistical Interaction With HLA Class II Genotypes
Deborah J. Smyth; Jason D. Cooper; Joanna M.M. Howson; Neil M. Walker; Vincent Plagnol; Helen Stevens; David G. Clayton; John A. Todd
Diabetes June 2008, Vol.57, 1730-1737. doi:https://doi.org/10.2337/db07-1131
Common Variants in Maturity-Onset Diabetes of the Young Genes and Future Risk of Type 2 Diabetes
Johan Holmkvist; Peter Almgren; Valeriya Lyssenko; Cecilia M. Lindgren; Karl-Fredrik Eriksson; Bo Isomaa; Tiinamaija Tuomi; Peter Nilsson; Leif Groop
Diabetes June 2008, Vol.57, 1738-1744. doi:https://doi.org/10.2337/db06-1464
The Diabetic Phenotype in HNF4A Mutation Carriers Is Moderated By the Expression of HNF4A Isoforms From the P1 Promoter During Fetal Development
Lorna W. Harries; Jonathan M. Locke; Beverley Shields; Neil A. Hanley; Karen Piper Hanley; Anna Steele; Pål R. Njølstad; Sian Ellard; Andrew T. Hattersley
Diabetes June 2008, Vol.57, 1745-1752. doi:https://doi.org/10.2337/db07-1742
Sequencing-Based Genotyping and Association Analysis of the MICA and MICB Genes in Type 1 Diabetes
Sarah F. Field; Sergey Nejentsev; Neil M. Walker; Joanna M.M. Howson; Lisa M. Godfrey; Jennifer D. Jolley; Matthew P.A. Hardy; John A. Todd
Diabetes June 2008, Vol.57, 1753-1756. doi:https://doi.org/10.2337/db07-1402
Erratum
Lai CQ, Tucker KL, Parnell LD, Adiconis X, García-Bailo B, Griffith J, Meydani M, Ordovás JM: PPARGC1A (PGC-1α) variation associated with DNA damage, diabetes, and cardiovascular diseases: the Boston Puerto Rican Health Study. Diabetes 57:1–8, 2008
Diabetes June 2008, Vol.57, 1757. doi:https://doi.org/10.2337/db08-er06
Online Letters to the Editor
Response to Comment on: Thallas-Bonke et al. (2008) Inhibition of NADPH Oxidase Prevents Advanced Glycation End Product–Mediated Damage in Diabetic Nephropathy Through a Protein Kinase C-α–Dependent Pathway: Diabetes 57:460–469, 2008
Diabetes June 2008, Vol.57, e14. doi:https://doi.org/10.2337/db08-0406