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Volume 57, Issue 7
July 2008
Diabetes Cover Image for Volume 57, Issue 7
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ISSN 0012-1797
EISSN 1939-327X
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Perspectives in Diabetes

Immunomodulation by Mesenchymal Stem Cells : A Potential Therapeutic Strategy for Type 1 Diabetes
Reza Abdi; Paolo Fiorina; Chaker N. Adra; Mark Atkinson; Mohamed H. Sayegh
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Diabetes July 2008, Vol.57, 1759-1767. doi:https://doi.org/10.2337/db08-0180
Neurophysiological Pathways to Obesity: Below Awareness and Beyond Individual Control
Deborah A. Cohen
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Diabetes July 2008, Vol.57, 1768-1773. doi:https://doi.org/10.2337/db08-0163
Protein Kinase C Function in Muscle, Liver, and β-Cells and Its Therapeutic Implications for Type 2 Diabetes
Carsten Schmitz-Peiffer; Trevor J. Biden
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Diabetes July 2008, Vol.57, 1774-1783. doi:https://doi.org/10.2337/db07-1769

Commentaries

The Pol-e-Pill Finally Arrives
James A. Levine; Ronald M. Davis
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Diabetes July 2008, Vol.57, 1784-1785. doi:https://doi.org/10.2337/db08-0108
Obesity: Increasing Awareness of Novel Environmental Factors
Kevin D. Niswender; Bettina M. Beech
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Diabetes July 2008, Vol.57, 1786-1787. doi:https://doi.org/10.2337/db08-0527
Low-Affinity Major Histocompatibility Complex–Binding Peptides in Type 1 Diabetes
Eddie A. James; William W. Kwok
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Diabetes July 2008, Vol.57, 1788-1789. doi:https://doi.org/10.2337/db08-0530

New Methodologies and Databases

Glucose Metabolism In Vivo in Four Commonly Used Inbred Mouse Strains
Eric D. Berglund; Candice Y. Li; Greg Poffenberger; Julio E. Ayala; Patrick T. Fueger; Shannon E. Willis; Marybeth M. Jewell; Alvin C. Powers; David H. Wasserman
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Diabetes July 2008, Vol.57, 1790-1799. doi:https://doi.org/10.2337/db07-1615

Metabolism

Plasma C5 Glucose–to–2H2O Ratio Does Not Provide an Accurate Assessment of Gluconeogenesis During Hyperinsulinemic-Euglycemic Clamps in Either Nondiabetic or Diabetic Humans
Rita Basu; Visvanathan Chandramouli; Betty Dicke; Bernard R. Landau; Robert A. Rizza
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Diabetes July 2008, Vol.57, 1800-1804. doi:https://doi.org/10.2337/db08-0195

Signal Transduction

Human Adenovirus Type 36 Enhances Glucose Uptake in Diabetic and Nondiabetic Human Skeletal Muscle Cells Independent of Insulin Signaling
Zhong Q. Wang; William T. Cefalu; Xian H. Zhang; Yongmei Yu; Jianhua Qin; Leslie Son; Pamela M. Rogers; Nazar Mashtalir; Justin R. Bordelon; Jianping Ye; Nikhil V. Dhurandhar
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Diabetes July 2008, Vol.57, 1805-1813. doi:https://doi.org/10.2337/db07-1313
Activation of Estrogen Receptor Is Crucial for Resveratrol-Stimulating Muscular Glucose Uptake via Both Insulin-Dependent and -Independent Pathways
Jen-Ying Deng; Po-Shiuan Hsieh; Jiung-Pang Huang; Long-Sheng Lu; Li-Man Hung
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Diabetes July 2008, Vol.57, 1814-1823. doi:https://doi.org/10.2337/db07-1750

Obesity Studies

Adiponectin Reduces Plasma Triglyceride by Increasing VLDL Triglyceride Catabolism
Liping Qiao; Chenhui Zou; Deneys R. van der Westhuyzen; Jianhua Shao
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Diabetes July 2008, Vol.57, 1824-1833. doi:https://doi.org/10.2337/db07-0435
Hormone-Sensitive Lipase Serine Phosphorylation and Glycerol Exchange Across Skeletal Muscle in Lean and Obese Subjects : Effect of β-Adrenergic Stimulation
Johan W.E. Jocken; Carsten Roepstorff; Gijs H. Goossens; Paula van der Baan; Marleen van Baak; Wim H.M. Saris; Bente Kiens; Ellen E. Blaak
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Diabetes July 2008, Vol.57, 1834-1841. doi:https://doi.org/10.2337/db07-0857
Blockade of α4 Integrin Signaling Ameliorates the Metabolic Consequences of High-Fat Diet–Induced Obesity
Chloé C. Féral; Jaap G. Neels; Christiane Kummer; Marina Slepak; Jerrold M. Olefsky; Mark H. Ginsberg
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Diabetes July 2008, Vol.57, 1842-1851. doi:https://doi.org/10.2337/db07-1751

Immunology and Transplantation

Weak Proinsulin Peptide–Major Histocompatibility Complexes Are Targeted in Autoimmune Diabetes in Mice
Matteo G. Levisetti; Danna M. Lewis; Anish Suri; Emil R. Unanue
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Diabetes July 2008, Vol.57, 1852-1860. doi:https://doi.org/10.2337/db08-0068
Protective Role of Programmed Death 1 Ligand 1 (PD-L1)in Nonobese Diabetic Mice : The Paradox in Transgenic Models
Chia-Jen Wang; Feng-Cheng Chou; Chi-Hong Chu; Jen-Chine Wu; Shih-Hua Lin; Deh-Ming Chang; Huey-Kang Sytwu
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Diabetes July 2008, Vol.57, 1861-1869. doi:https://doi.org/10.2337/db07-1260
Improved Vascular Engraftment and Graft Function After Inhibition of the Angiostatic Factor Thrombospondin-1 in Mouse Pancreatic Islets
Johan Olerud; Magnus Johansson; Jack Lawler; Nils Welsh; Per-Ola Carlsson
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Diabetes July 2008, Vol.57, 1870-1877. doi:https://doi.org/10.2337/db07-0724
Immunoglobulin-Like Transcript 3-Fc Suppresses T-Cell Responses to Allogeneic Human Islet Transplants in hu-NOD/SCID Mice
George Vlad; Vivette D. D'Agati; Qing-Yin Zhang; Zhuoru Liu; Eric K. Ho; Thalachallour Mohanakumar; Mark A. Hardy; Raffaello Cortesini; Nicole Suciu-Foca
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Diabetes July 2008, Vol.57, 1878-1886. doi:https://doi.org/10.2337/db08-0054

Islet Studies

Fructose-1,6-Bisphosphatase Overexpression in Pancreatic β-Cells Results in Reduced Insulin Secretion : A New Mechanism for Fat-Induced Impairment of β-Cell Function
Melkam Kebede; Jenny Favaloro; Jenny E. Gunton; D. Ross Laybutt; Margaret Shaw; Nicole Wong; Barbara C. Fam; Kathryn Aston-Mourney; Christian Rantzau; Anthony Zulli; Joseph Proietto; Sofianos Andrikopoulos
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Diabetes July 2008, Vol.57, 1887-1895. doi:https://doi.org/10.2337/db07-1326
MAPK Kinase Kinase-1 Is Essential for Cytokine-Induced c-Jun NH2-Terminal Kinase and Nuclear Factor-κB Activation in Human Pancreatic Islet Cells
Dariush Mokhtari; Jason W. Myers; Nils Welsh
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Diabetes July 2008, Vol.57, 1896-1904. doi:https://doi.org/10.2337/db07-1670

Pathophysiology

Effect of Oral Amino Acids on Counterregulatory Responses and Cognitive Function During Insulin-Induced Hypoglycemia in Nondiabetic and Type 1 Diabetic People
Paolo Rossetti; Francesca Porcellati; Natalia Busciantella Ricci; Paola Candeloro; Patrizia Cioli; K. Sreekumaran Nair; Fausto Santeusanio; Geremia B. Bolli; Carmine G. Fanelli
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Diabetes July 2008, Vol.57, 1905-1917. doi:https://doi.org/10.2337/db08-0276
Circulating Retinol-Binding Protein-4 Concentration Might Reflect Insulin Resistance–Associated Iron Overload
José Manuel Fernández-Real; José María Moreno; Wifredo Ricart
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Diabetes July 2008, Vol.57, 1918-1925. doi:https://doi.org/10.2337/db08-0041
Protein Engineering Strategies for Sustained Glucagon-Like Peptide-1 Receptor–Dependent Control of Glucose Homeostasis
Kristen M. Picha; Mark R. Cunningham; Daniel J. Drucker; Ashok Mathur; Tatiana Ort; Michael Scully; Avery Soderman; Tracy Spinka-Doms; Vedrana Stojanovic-Susulic; Beth Ann Thomas; Karyn T. O'Neil
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Diabetes July 2008, Vol.57, 1926-1934. doi:https://doi.org/10.2337/db07-1775
Novel De Novo Mutation in Sulfonylurea Receptor 1 Presenting as Hyperinsulinism in Infancy Followed by Overt Diabetes in Early Adolescence
Maha Abdulhadi-Atwan; Jeremy D. Bushman; Sharona Tornovsky-Babaey; Avital Perry; Abdulsalam Abu-Libdeh; Benjamin Glaser; Show-Ling Shyng; David H. Zangen
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Diabetes July 2008, Vol.57, 1935-1940. doi:https://doi.org/10.2337/db08-0159

Complications

RAGE and Modulation of Ischemic Injury in the Diabetic Myocardium
Loredana G. Bucciarelli; Radha Ananthakrishnan; Yuying C. Hwang; Michiyo Kaneko; Fei Song; David R. Sell; Christopher Strauch; Vincent M. Monnier; Shi Fang Yan; Ann Marie Schmidt; Ravichandran Ramasamy
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Diabetes July 2008, Vol.57, 1941-1951. doi:https://doi.org/10.2337/db07-0326
Hyperglycemia-Induced Reactive Oxygen Species Toxicity to Endothelial Cells Is Dependent on Paracrine Mediators
Julia V. Busik; Susanne Mohr; Maria B. Grant
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Diabetes July 2008, Vol.57, 1952-1965. doi:https://doi.org/10.2337/db07-1520
Serum Heat Shock Protein 27 and Diabetes Complications in the EURODIAB Prospective Complications Study : A Novel Circulating Marker for Diabetic Neuropathy
Gabriella Gruden; Graziella Bruno; Nish Chaturvedi; Davina Burt; Casper Schalkwijk; Silvia Pinach; Coen D. Stehouwer; Daniel R. Witte; John H. Fuller; Paolo Cavallo Perin; the EURODIAB Prospective Complications Study Group
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Diabetes July 2008, Vol.57, 1966-1970. doi:https://doi.org/10.2337/db08-0009

Genetics

Haplotype Structure of the ENPP1 Gene and Nominal Association of the K121Q Missense Single Nucleotide Polymorphism With Glycemic Traits in the Framingham Heart Study
Elliot S. Stolerman; Alisa K. Manning; Jarred B. McAteer; Josée Dupuis; Caroline S. Fox; L. Adrienne Cupples; James B. Meigs; Jose C. Florez
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Diabetes July 2008, Vol.57, 1971-1977. doi:https://doi.org/10.2337/db08-0266
Diabetes Susceptibility in the Canadian Oji-Cree Population Is Moderated by Abnormal mRNA Processing of HNF1A G319S Transcripts
Lorna W. Harries; Melissa J. Sloman; Elizabeth A.C. Sellers; Andrew T. Hattersley; Sian Ellard
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Diabetes July 2008, Vol.57, 1978-1982. doi:https://doi.org/10.2337/db07-1633
Association Analysis of Type 2 Diabetes Loci in Type 1 Diabetes
Hui-Qi Qu; Struan F.A. Grant; Jonathan P. Bradfield; Cecilia Kim; Edward Frackelton; Hakon Hakonarson; Constantin Polychronakos
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Diabetes July 2008, Vol.57, 1983-1986. doi:https://doi.org/10.2337/db08-0270
Association of FTO With Obesity-Related Traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort
Amanda F. Marvelle; Leslie A. Lange; Li Qin; Linda S. Adair; Karen L. Mohlke
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Diabetes July 2008, Vol.57, 1987-1991. doi:https://doi.org/10.2337/db07-1700
Evaluation of the Association of IGF2BP2 Variants With Type 2 Diabetes in French Caucasians
Konsta Duesing; Ghazaleh Fatemifar; Guillaume Charpentier; Michel Marre; Jean Tichet; Serge Hercberg; Beverley Balkau; Philippe Froguel; Fernando Gibson
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Diabetes July 2008, Vol.57, 1992-1996. doi:https://doi.org/10.2337/db07-1789
Système International (SI) Units Table
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus
Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes: Many Differences, Few Similarities
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