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Metabolism
Obese Mice Lacking Inducible Nitric Oxide Synthase Are Sensitized to the Metabolic Actions of Peroxisome Proliferator–Activated Receptor-γ Agonism
Patrice Dallaire; Kerstin Bellmann; Mathieu Laplante; Stéphanie Gélinas; Carolina Centeno-Baez; Patrice Penfornis; Marie-Line Peyot; Martin G. Latour; Julien Lamontagne; Maria E. Trujillo; Philipp E. Scherer; Marc Prentki; Yves Deshaies; André Marette
Diabetes August 2008, Vol.57, 1999-2011. doi:https://doi.org/10.2337/db08-0540
Partial Resistance to Peroxisome Proliferator–Activated Receptor-α Agonists in ZDF Rats Is Associated With Defective Hepatic Mitochondrial Metabolism
Santhosh Satapati; TianTeng He; Takeshi Inagaki; Matthew Potthoff; Matthew E. Merritt; Victoria Esser; David J. Mangelsdorf; Steven A. Kliewer; Jeffrey D. Browning; Shawn C. Burgess
Diabetes August 2008, Vol.57, 2012-2021. doi:https://doi.org/10.2337/db08-0226
Relationship of Abdominal Visceral and Subcutaneous Adipose Tissue With Lipoprotein Particle Number and Size in Type 2 Diabetes
Susan Sam; Steven Haffner; Michael H. Davidson; Ralph B. D'Agostino, Sr.; Steven Feinstein; George Kondos; Alfonso Perez; Theodore Mazzone
Diabetes August 2008, Vol.57, 2022-2027. doi:https://doi.org/10.2337/db08-0157
Cannabinoid Type 1 Receptor Blockade Promotes Mitochondrial Biogenesis Through Endothelial Nitric Oxide Synthase Expression in White Adipocytes
Laura Tedesco; Alessandra Valerio; Cristina Cervino; Annalisa Cardile; Claudio Pagano; Roberto Vettor; Renato Pasquali; Michele O. Carruba; Giovanni Marsicano; Beat Lutz; Uberto Pagotto; Enzo Nisoli
Diabetes August 2008, Vol.57, 2028-2036. doi:https://doi.org/10.2337/db07-1623
Consequences of Lipid Droplet Coat Protein Downregulation in Liver Cells: Abnormal Lipid Droplet Metabolism and Induction of Insulin Resistance
Ming Bell; Hong Wang; Hui Chen; John C. McLenithan; Da-Wei Gong; Rong-Zee Yang; Daozhan Yu; Susan K. Fried; Michael J. Quon; Constantine Londos; Carole Sztalryd
Diabetes August 2008, Vol.57, 2037-2045. doi:https://doi.org/10.2337/db07-1383
Arcuate Glucagon-Like Peptide 1 Receptors Regulate Glucose Homeostasis but Not Food Intake
Diabetes August 2008, Vol.57, 2046-2054. doi:https://doi.org/10.2337/db07-1824
The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential for Normal Adipocyte Differentiation
Victoria A. Payne; Neil Grimsey; Antoinette Tuthill; Sam Virtue; Sarah L. Gray; Edoardo Dalla Nora; Robert K. Semple; Stephen O'Rahilly; Justin J. Rochford
Diabetes August 2008, Vol.57, 2055-2060. doi:https://doi.org/10.2337/db08-0184
Hypothalamic Protein Kinase C Regulates Glucose Production
Rachel Ross; Penny Y.T. Wang; Madhu Chari; Carol K.L. Lam; Liora Caspi; Hiraku Ono; Evan D. Muse; Xiaosong Li; Roger Gutierrez-Juarez; Peter E. Light; Gary J. Schwartz; Luciano Rossetti; Tony K.T. Lam
Diabetes August 2008, Vol.57, 2061-2065. doi:https://doi.org/10.2337/db08-0206
Signal Transduction
siRNA-Mediated Reduction of Inhibitor of Nuclear Factor-κB Kinase Prevents Tumor Necrosis Factor-α–Induced Insulin Resistance in Human Skeletal Muscle
Diabetes August 2008, Vol.57, 2066-2073. doi:https://doi.org/10.2337/db07-0763
Autocrine IGF-1 Action in Adipocytes Controls Systemic IGF-1 Concentrations and Growth
Nora Klöting; Linda Koch; Thomas Wunderlich; Matthias Kern; Karen Ruschke; Wilhelm Krone; Jens C. Brüning; Matthias Blüher
Diabetes August 2008, Vol.57, 2074-2082. doi:https://doi.org/10.2337/db07-1538
Impact of Oxidative Stress and Peroxisome Proliferator–Activated Receptor γ Coactivator-1α in Hepatic Insulin Resistance
Naoki Kumashiro; Yoshifumi Tamura; Toyoyoshi Uchida; Takeshi Ogihara; Yoshio Fujitani; Takahisa Hirose; Hideki Mochizuki; Ryuzo Kawamori; Hirotaka Watada
Diabetes August 2008, Vol.57, 2083-2091. doi:https://doi.org/10.2337/db08-0144
Obesity Studies
Brain Apolipoprotein E: an Important Regulator of Food Intake in Rats
Ling Shen; Patrick Tso; Stephen C. Woods; Deborah J. Clegg; Kyna L. Barber; Katherine Carey; Min Liu
Diabetes August 2008, Vol.57, 2092-2098. doi:https://doi.org/10.2337/db08-0291
Immunology and Transplantation
T-Cell Promiscuity in Autoimmune Diabetes
Diabetes August 2008, Vol.57, 2099-2106. doi:https://doi.org/10.2337/db08-0383
Extracellular High-Mobility Group Box 1 Acts as an Innate Immune Mediator to Enhance Autoimmune Progression and Diabetes Onset in NOD Mice
Junyan Han; Jinxin Zhong; Wenzhong Wei; Ying Wang; Yafei Huang; Ping Yang; Sharad Purohit; Zheng Dong; Mong-Heng Wang; Jin-Xiong She; Feili Gong; David M. Stern; Cong-Yi Wang
Diabetes August 2008, Vol.57, 2118-2127. doi:https://doi.org/10.2337/db07-1499
Pancreatic Duct Cells in Human Islet Cell Preparations Are a Source of Angiogenic Cytokines Interleukin-8 and Vascular Endothelial Growth Factor
Babak Movahedi; Conny Gysemans; Daniel Jacobs-Tulleneers-Thevissen; Chantal Mathieu; Daniel Pipeleers
Diabetes August 2008, Vol.57, 2128-2136. doi:https://doi.org/10.2337/db07-1705
Islet Studies
PANIC-ATTAC: A Mouse Model for Inducible and Reversible β-Cell Ablation
Zhao V. Wang; James Mu; Todd D. Schraw; Laurent Gautron; Joel K. Elmquist; Bei B. Zhang; Michael Brownlee; Philipp E. Scherer
Diabetes August 2008, Vol.57, 2137-2148. doi:https://doi.org/10.2337/db07-1631
Pathophysiology
Activation of Peroxisome Proliferator–Activated Receptor β/δ Inhibits Lipopolysaccharide-Induced Cytokine Production in Adipocytes by Lowering Nuclear Factor-κB Activity via Extracellular Signal–Related Kinase 1/2
Ricardo Rodríguez-Calvo; Lucía Serrano; Teresa Coll; Norman Moullan; Rosa M. Sánchez; Manuel Merlos; Xavier Palomer; Juan C. Laguna; Liliane Michalik; Walter Wahli; Manuel Vázquez-Carrera
Diabetes August 2008, Vol.57, 2149-2157. doi:https://doi.org/10.2337/db08-0176
Altered Calcium Homeostasis Does Not Explain the Contractile Deficit of Diabetic Cardiomyopathy
Diabetes August 2008, Vol.57, 2158-2166. doi:https://doi.org/10.2337/db08-0140
Complications
Exposure to Maternal Diabetes Induces Salt-Sensitive Hypertension and Impairs Renal Function in Adult Rat Offspring
Touria Nehiri; Jean-Paul Duong Van Huyen; Mélanie Viltard; Céline Fassot; Didier Heudes; Nicole Freund; Georges Deschênes; Pascal Houillier; Patrick Bruneval; Martine Lelièvre-Pégorier
Diabetes August 2008, Vol.57, 2167-2175. doi:https://doi.org/10.2337/db07-0780
Heritability of Proliferative Diabetic Retinopathy
Kustaa Hietala; Carol Forsblom; Paula Summanen; Per-Henrik Groop; on behalf of the FinnDiane Study Group
Diabetes August 2008, Vol.57, 2176-2180. doi:https://doi.org/10.2337/db07-1495
Protein Kinase C-δ Mediates Neuronal Apoptosis in the Retinas of Diabetic Rats via the Akt Signaling Pathway
Young-Hee Kim; Yoon-Sook Kim; Chang-Hwan Park; In-Yong Chung; Ji-Myong Yoo; Jae-Geun Kim; Byung-Ju Lee; Sang-Soo Kang; Gyeong-Jae Cho; Wan-Sung Choi
Diabetes August 2008, Vol.57, 2181-2190. doi:https://doi.org/10.2337/db07-1431
Angiotensin II Type 1 Receptor Signaling Contributes to Synaptophysin Degradation and Neuronal Dysfunction in the Diabetic Retina
Toshihide Kurihara; Yoko Ozawa; Norihiro Nagai; Kei Shinoda; Kousuke Noda; Yutaka Imamura; Kazuo Tsubota; Hideyuki Okano; Yuichi Oike; Susumu Ishida
Diabetes August 2008, Vol.57, 2191-2198. doi:https://doi.org/10.2337/db07-1281
Pharmacology and Therapeutics
Pck1 Gene Silencing in the Liver Improves Glycemia Control, Insulin Sensitivity, and Dyslipidemia in db/db Mice
Alicia G. Gómez-Valadés; Andrés Méndez-Lucas; Anna Vidal-Alabró; Francese X. Blasco; Miguel Chillon; Ramon Bartrons; Jordi Bermúdez; José C. Perales
Diabetes August 2008, Vol.57, 2199-2210. doi:https://doi.org/10.2337/db07-1087
Selective Small-Molecule Agonists of G Protein–Coupled Receptor 40 Promote Glucose-Dependent Insulin Secretion and Reduce Blood Glucose in Mice
Carina P. Tan; Yue Feng; Yun-Ping Zhou; George J. Eiermann; Aleksandr Petrov; Changyou Zhou; Songnian Lin; Gino Salituro; Peter Meinke; Ralph Mosley; Taro E. Akiyama; Monica Einstein; Sanjeev Kumar; Joel P. Berger; Sander G. Mills; Nancy A. Thornberry; Lihu Yang; Andrew D. Howard
Diabetes August 2008, Vol.57, 2211-2219. doi:https://doi.org/10.2337/db08-0130
Genetics
Association Analysis in African Americans of European-Derived Type 2 Diabetes Single Nucleotide Polymorphisms From Whole-Genome Association Studies
Joshua P. Lewis; Nicholette D. Palmer; Pamela J. Hicks; Michele M. Sale; Carl D. Langefeld; Barry I. Freedman; Jasmin Divers; Donald W. Bowden
Diabetes August 2008, Vol.57, 2220-2225. doi:https://doi.org/10.2337/db07-1319
Implication of Genetic Variants Near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in Type 2 Diabetes and Obesity in 6,719 Asians
Maggie C.Y. Ng; Kyong Soo Park; Bermseok Oh; Claudia H.T. Tam; Young Min Cho; Hyoung Doo Shin; Vincent K.L. Lam; Ronald C.W. Ma; Wing Yee So; Yoon Shin Cho; Hyung-Lae Kim; Hong Kyu Lee; Juliana C.N. Chan; Nam H. Cho
Diabetes August 2008, Vol.57, 2226-2233. doi:https://doi.org/10.2337/db07-1583
Role of the Transcription Factor Sox4 in Insulin Secretion and Impaired Glucose Tolerance
Michelle Goldsworthy; Alison Hugill; Helen Freeman; Emma Horner; Kenju Shimomura; Debora Bogani; Guido Pieles; Vesna Mijat; Ruth Arkell; Shoumo Bhattacharya; Frances M. Ashcroft; Roger D. Cox
Diabetes August 2008, Vol.57, 2234-2244. doi:https://doi.org/10.2337/db07-0337
Common Variation in the Fat Mass and Obesity-Associated (FTO) Gene Confers Risk of Obesity and Modulates BMI in the Chinese Population
Yi-Cheng Chang; Pi-Hua Liu; Wei-Jei Lee; Tien-Jyun Chang; Yi-Der Jiang; Hung-Yuan Li; Shan-Shan Kuo; Kuang-Chin Lee; Lee-Ming Chuang
Diabetes August 2008, Vol.57, 2245-2252. doi:https://doi.org/10.2337/db08-0377
The Common P446L Polymorphism in GCKR Inversely Modulates Fasting Glucose and Triglyceride Levels and Reduces Type 2 Diabetes Risk in the DESIR Prospective General French Population
Martine Vaxillaire; Christine Cavalcanti-Proença; Aurélie Dechaume; Jean Tichet; Michel Marre; Beverley Balkau; Philippe Froguel; for the DESIR Study Group
Diabetes August 2008, Vol.57, 2253-2257. doi:https://doi.org/10.2337/db07-1807