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Editorial
OSA Lecture 2008
Commentaries
Selective Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 for Patients With Metabolic Syndrome: Is the Target Liver, Fat, or Both?
Diabetes January 2009, Vol.58, 14-15. doi:https://doi.org/10.2337/db08-1404
Fat Partitioning and Insulin Sensitivity: Robbing Peter to Pay Paul?
Diabetes January 2009, Vol.58, 16-17. doi:https://doi.org/10.2337/db08-1466
Hypoglycemic Detection at the Portal Vein: Absent in Humans or Yet to Be Elucidated?
Diabetes January 2009, Vol.58, 21-23. doi:https://doi.org/10.2337/db08-1437
Breathing Room: The (Un)Natural History of Adipose Microhypoxia and Insulin Resistance
Diabetes January 2009, Vol.58, 26-27. doi:https://doi.org/10.2337/db08-1517
Sleeping Beauty, Awake! Regulation of Insulin Gene Expression by Methylation of Histone H3
Diabetes January 2009, Vol.58, 28-29. doi:https://doi.org/10.2337/db08-1520
New Methodologies and Databases
Increased Secretion and Expression of Myostatin in Skeletal Muscle From Extremely Obese Women
Diabetes January 2009, Vol.58, 30-38. doi:https://doi.org/10.2337/db08-0943
Metabolism
Liver Is the Site of Splanchnic Cortisol Production in Obese Nondiabetic Humans
Rita Basu; Ananda Basu; Meagan Grudzien; Paul Jung; Peer Jacobson; Michael Johnson; Ravinder Singh; Michael Sarr; Robert A. Rizza
Diabetes January 2009, Vol.58, 39-45. doi:https://doi.org/10.2337/db08-1079
Adiponectin Upregulates Ferritin Heavy Chain in Skeletal Muscle Cells
Yuichi Ikegami; Kouichi Inukai; Kenta Imai; Yasushi Sakamoto; Hideki Katagiri; Susumu Kurihara; Takuya Awata; Shigehiro Katayama
Diabetes January 2009, Vol.58, 61-70. doi:https://doi.org/10.2337/db07-0690
Mid- and Late-Life Diabetes in Relation to the Risk of Dementia: A Population-Based Twin Study
Diabetes January 2009, Vol.58, 71-77. doi:https://doi.org/10.2337/db08-0586
Restoration of Hepatic Glucokinase Expression Corrects Hepatic Glucose Flux and Normalizes Plasma Glucose in Zucker Diabetic Fatty Rats
Tracy P. Torres; ReEtta L. Catlin; Robert Chan; Yuka Fujimoto; Noriyasu Sasaki; Richard L. Printz; Christopher B. Newgard; Masakazu Shiota
Diabetes January 2009, Vol.58, 78-86. doi:https://doi.org/10.2337/db08-1119
Xenin, a Gastrointestinal Peptide, Regulates Feeding Independent of the Melanocortin Signaling Pathway
Diabetes January 2009, Vol.58, 87-94. doi:https://doi.org/10.2337/db08-0260
Signal Transduction
Hypoxia Decreases Insulin Signaling Pathways in Adipocytes
Claire Regazzetti; Pascal Peraldi; Thierry Grémeaux; Rosanna Najem-Lendom; Issam Ben-Sahra; Mireille Cormont; Frédéric Bost; Yannick Le Marchand-Brustel; Jean-François Tanti; Sophie Giorgetti-Peraldi
Diabetes January 2009, Vol.58, 95-103. doi:https://doi.org/10.2337/db08-0457
Obesity Studies
Elevated Expression of Osteopontin May Be Related to Adipose Tissue Macrophage Accumulation and Liver Steatosis in Morbid Obesity
Adeline Bertola; Vanessa Deveaux; Stéphanie Bonnafous; Déborah Rousseau; Rodolphe Anty; Abdelilah Wakkach; Moncef Dahman; Joan Tordjman; Karine Clément; Siobhán E. McQuaid; Keith N. Frayn; Pierre-Michel Huet; Jean Gugenheim; Sophie Lotersztajn; Yannick Le Marchand-Brustel; Albert Tran; Philippe Gual
Diabetes January 2009, Vol.58, 125-133. doi:https://doi.org/10.2337/db08-0400
Association of Parental Obesity With Concentrations of Select Systemic Biomarkers in Nonobese Offspring : The Framingham Heart Study
Wolfgang Lieb; Michael J. Pencina; Katherine J. Lanier; Geoffrey H. Tofler; Daniel Levy; Caroline S. Fox; Thomas J. Wang; Ralph B. D'Agostino, Sr.; Ramachandran S. Vasan
Diabetes January 2009, Vol.58, 134-137. doi:https://doi.org/10.2337/db08-0918
Original Article
Obesity Studies
Skeletal Muscle–Specific Deletion of Lipoprotein Lipase Enhances Insulin Signaling in Skeletal Muscle but Causes Insulin Resistance in Liver and Other Tissues
Hong Wang; Leslie A. Knaub; Dalan R. Jensen; Dae Young Jung; Eun-Gyoung Hong; Hwi-Jin Ko; Alison M. Coates; Ira J. Goldberg; Becky A. de la Houssaye; Rachel C. Janssen; Carrie E. McCurdy; Shaikh M. Rahman; Cheol Soo Choi; Gerald I. Shulman; Jason K. Kim; Jacob E. Friedman; Robert H. Eckel
Diabetes October 2008, Vol.58, 116-124. doi:https://doi.org/10.2337/db07-1839
Immunology and Transplantation
Plasmacytoid Dendritic Cells Are Proportionally Expanded at Diagnosis of Type 1 Diabetes and Enhance Islet Autoantigen Presentation to T-Cells Through Immune Complex Capture
Jennifer S. Allen; Karl Pang; Ania Skowera; Richard Ellis; Chloe Rackham; Biliana Lozanoska-Ochser; Timothy Tree; R. David G. Leslie; Jennifer M. Tremble; Colin M. Dayan; Mark Peakman
Diabetes January 2009, Vol.58, 138-145. doi:https://doi.org/10.2337/db08-0964
Slc11a1 Enhances the Autoimmune Diabetogenic T-Cell Response by Altering Processing and Presentation of Pancreatic Islet Antigens
Diabetes January 2009, Vol.58, 156-164. doi:https://doi.org/10.2337/db07-1608
Idd Loci Synergize to Prolong Islet Allograft Survival Induced by Costimulation Blockade in NOD Mice
Julie Mangada; Todd Pearson; Michael A. Brehm; Linda S. Wicker; Laurence B. Peterson; Leonard D. Shultz; David V. Serreze; Aldo A. Rossini; Dale L. Greiner
Diabetes January 2009, Vol.58, 165-173. doi:https://doi.org/10.2337/db08-0275
Islet Studies
Regulation of Calcium-Permeable TRPV2 Channel by Insulin in Pancreatic β-Cells
Diabetes January 2009, Vol.58, 174-184. doi:https://doi.org/10.2337/db08-0862
Methyltransferase Set7/9 Maintains Transcription and Euchromatin Structure at Islet-Enriched Genes
Diabetes January 2009, Vol.58, 185-193. doi:https://doi.org/10.2337/db08-1150
Pathophysiology
Portal Vein Glucose Sensors Do Not Play a Major Role in Modulating Physiological Responses to Insulin-Induced Hypoglycemia in Humans
Paolo Rossetti; Francesca Porcellati; Paola Lucidi; Natalia Busciantella Ricci; Paola Candeloro; Patrizia Cioli; Fausto Santeusanio; Geremia B. Bolli; Carmine G. Fanelli
Diabetes January 2009, Vol.58, 194-202. doi:https://doi.org/10.2337/db08-0641
Hepatic Stearoyl-CoA Desaturase (SCD)-1 Activity and Diacylglycerol but Not Ceramide Concentrations Are Increased in the Nonalcoholic Human Fatty Liver
Anna Kotronen; Tuulikki Seppänen-Laakso; Jukka Westerbacka; Tuula Kiviluoto; Johanna Arola; Anna-Liisa Ruskeepää; Matej Orešič; Hannele Yki-Järvinen
Diabetes January 2009, Vol.58, 203-208. doi:https://doi.org/10.2337/db08-1074
Complications
Vessel Shrinkage as a Sign of Atherosclerosis Progression in Type 2 Diabetes : A Serial Intravascular Ultrasound Analysis
Pilar Jiménez-Quevedo; Nobuaki Suzuki; Cecilia Corros; Cruz Ferrer; Dominick J. Angiolillo; Fernando Alfonso; Rosana Hernández-Antolín; Camino Bañuelos; Javier Escaned; Cristina Fernández; Marco Costa; Carlos Macaya; Theodore Bass; Manel Sabaté
Diabetes January 2009, Vol.58, 209-214. doi:https://doi.org/10.2337/db08-0376
Rho Kinase Inhibition by Fasudil Ameliorates Diabetes-Induced Microvascular Damage
Ryoichi Arita; Yasuaki Hata; Shintaro Nakao; Takeshi Kita; Muneki Miura; Shuhei Kawahara; Souska Zandi; Lama Almulki; Faryan Tayyari; Hiroaki Shimokawa; Ali Hafezi-Moghadam; Tatsuro Ishibashi
Diabetes January 2009, Vol.58, 215-226. doi:https://doi.org/10.2337/db08-0762
Role of Glyceraldehyde 3-Phosphate Dehydrogenase in the Development and Progression of Diabetic Retinopathy
Diabetes January 2009, Vol.58, 227-234. doi:https://doi.org/10.2337/db08-1025
Pharmacology & Therapeutics
Insulin Reduces Cerebral Ischemia/Reperfusion Injury in the Hippocampus of Diabetic Rats: A Role for Glycogen Synthase Kinase-3β
Massimo Collino; Manuela Aragno; Sara Castiglia; Chiara Tomasinelli; Christoph Thiemermann; Giuseppe Boccuzzi; Roberto Fantozzi
Diabetes January 2009, Vol.58, 235-242. doi:https://doi.org/10.2337/db08-0691
Inhibition of Dipeptidyl Peptidase-4 by Vildagliptin During Glucagon-Like Peptide 1 Infusion Increases Liver Glucose Uptake in the Conscious Dog
Dale S. Edgerton; Kathryn M.S. Johnson; Doss W. Neal; Melanie Scott; Charles H. Hobbs; Xia Zhang; Alokesh Duttaroy; Alan D. Cherrington
Diabetes January 2009, Vol.58, 243-249. doi:https://doi.org/10.2337/db08-0515
Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice
Jing Xu; David J. Lloyd; Clarence Hale; Shanaka Stanislaus; Michelle Chen; Glenn Sivits; Steven Vonderfecht; Randy Hecht; Yue-Sheng Li; Richard A. Lindberg; Jin-Long Chen; Dae Young Jung; Zhiyou Zhang; Hwi-Jin Ko; Jason K. Kim; Murielle M. Véniant
Diabetes January 2009, Vol.58, 250-259. doi:https://doi.org/10.2337/db08-0392
Genetics
Genome-Wide Linkage Scan in Gullah-Speaking African American Families With Type 2 Diabetes: The Sea Islands Genetic African American Registry (Project SuGAR)
Michèle M. Sale; Lingyi Lu; Ida J. Spruill; Jyotika K. Fernandes; Kerry H. Lok; Jasmin Divers; Carl D. Langefeld; W. Timothy Garvey
Diabetes January 2009, Vol.58, 260-267. doi:https://doi.org/10.2337/db08-0198
Interleukin-6 Receptor Gene, Plasma C-Reactive Protein, and Diabetes Risk in Women
Diabetes January 2009, Vol.58, 275-278. doi:https://doi.org/10.2337/db08-0968
Genome-Wide Linkage Scan for Genes Influencing Plasma Triglyceride Levels in the Veterans Administration Genetic Epidemiology Study
Dawn K. Coletta; Jennifer Schneider; Shirley L. Hu; Thomas D. Dyer; Sobha Puppala; Vidya S. Farook; Rector Arya; Donna M. Lehman; John Blangero; Ralph A. DeFronzo; Ravindranath Duggirala; Christopher P. Jenkinson
Diabetes January 2009, Vol.58, 279-284. doi:https://doi.org/10.2337/db08-0491
Transcription Factor 7-Like 2 (TCF7L2) Polymorphism and Context-Specific Risk of Type 2 Diabetes in African American and Caucasian Adults: The Atherosclerosis Risk in Communities Study
Yu Yan; Kari E. North; Christie M. Ballantyne; Frederick L. Brancati; Lloyd E. Chambless; Nora Franceschini; Gerardo Heiss; Anna Kottgen; James S. Pankow; Elizabeth Selvin; Suzanne L. West; Eric Boerwinkle
Diabetes January 2009, Vol.58, 285-289. doi:https://doi.org/10.2337/db08-0569
Follow-Up Analysis of Genome-Wide Association Data Identifies Novel Loci for Type 1 Diabetes
Struan F.A. Grant; Hui-Qi Qu; Jonathan P. Bradfield; Luc Marchand; Cecilia E. Kim; Joseph T. Glessner; Rosemarie Grabs; Shayne P. Taback; Edward C. Frackelton; Andrew W. Eckert; Kiran Annaiah; Margaret L. Lawson; F. George Otieno; Erin Santa; Julie L. Shaner; Ryan M. Smith; Robert Skraban; Marcin Imielinski; Rosetta M. Chiavacci; Robert W. Grundmeier; Charles A. Stanley; Susan E. Kirsch; Daryl Waggott; Andrew D. Paterson; Dimitri S. Monos; the DCCT/EDIC Research Group; Constantin Polychronakos; Hakon Hakonarson
Diabetes January 2009, Vol.58, 290-295. doi:https://doi.org/10.2337/db08-1022
