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Issues
Editorial
ADA Research Funding in 2009: Where Will We Be?
Topics:
clinical research
,
conflict of interest
,
decision making
,
diabetes mellitus complications
,
eye
Diabetes January 2009, Vol.58, 1. doi:https://doi.org/10.2337/db08-1395
OSA Lecture 2008
Can We Learn From Viruses How to Prevent Type 1 Diabetes?: The Role of Viral Infections in the Pathogenesis of Type 1 Diabetes and the Development of Novel Combination Therapies
Topics:
diabetes mellitus, type 1
,
virus diseases
,
antigens
Diabetes January 2009, Vol.58, 2-11. doi:https://doi.org/10.2337/db08-9027
Commentaries
Role of Plasmacytoid Dendritic Cells in Type 1 Diabetes: Friend or Foe?
Topics:
dendritic cells
,
diabetes mellitus, type 1
,
t-lymphocytes
Diabetes January 2009, Vol.58, 12-13. doi:https://doi.org/10.2337/db08-1341
Selective Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 for Patients With Metabolic Syndrome: Is the Target Liver, Fat, or Both?
Topics:
hydrocortisone
,
hydroxysteroids
,
liver
,
metabolic syndrome x
,
oxidoreductase
Diabetes January 2009, Vol.58, 14-15. doi:https://doi.org/10.2337/db08-1404
Fat Partitioning and Insulin Sensitivity: Robbing Peter to Pay Paul?
Topics:
fatty acids
,
insulin resistance
,
insulin sensitivity
,
lipoprotein lipase
,
triglycerides
Diabetes January 2009, Vol.58, 16-17. doi:https://doi.org/10.2337/db08-1466
Targeting Hepatic Glucokinase in Type 2 Diabetes: Weighing the Benefits and Risks
Topics:
diabetes mellitus, type 2
,
glucokinase
,
glucose
Diabetes January 2009, Vol.58, 18-20. doi:https://doi.org/10.2337/db08-1470
Hypoglycemic Detection at the Portal Vein: Absent in Humans or Yet to Be Elucidated?
Topics:
hypoglycemic agents
,
portal vein
,
glucose
Diabetes January 2009, Vol.58, 21-23. doi:https://doi.org/10.2337/db08-1437
Taking a Daily Vitamin to Prevent Type 1 Diabetes?
Topics:
diabetes mellitus, type 1
,
vitamins
Diabetes January 2009, Vol.58, 24-25. doi:https://doi.org/10.2337/db08-1479
Breathing Room: The (Un)Natural History of Adipose Microhypoxia and Insulin Resistance
Topics:
inspiration
,
insulin resistance
,
obesity
,
respiration
,
hypoxia
Diabetes January 2009, Vol.58, 26-27. doi:https://doi.org/10.2337/db08-1517
Sleeping Beauty, Awake! Regulation of Insulin Gene Expression by Methylation of Histone H3
Topics:
histone h3
,
insulin
,
methylation
,
sleep
,
beauty
Diabetes January 2009, Vol.58, 28-29. doi:https://doi.org/10.2337/db08-1520
New Methodologies and Databases
Increased Secretion and Expression of Myostatin in Skeletal Muscle From Extremely Obese Women
Topics:
bodily secretions
,
culture media, conditioned
,
obesity, morbid
,
skeletal muscles
,
skeletal myocytes
Diabetes January 2009, Vol.58, 30-38. doi:https://doi.org/10.2337/db08-0943
Metabolism
Liver Is the Site of Splanchnic Cortisol Production in Obese Nondiabetic Humans
Rita Basu; Ananda Basu; Meagan Grudzien; Paul Jung; Peer Jacobson; Michael Johnson; Ravinder Singh; Michael Sarr; Robert A. Rizza
Topics:
hydrocortisone
,
liver
,
viscera
,
obesity
,
cortisone
Diabetes January 2009, Vol.58, 39-45. doi:https://doi.org/10.2337/db08-1079
Cortisol Release From Adipose Tissue by 11β-Hydroxysteroid Dehydrogenase Type 1 in Humans
Roland H. Stimson; Jonas Andersson; Ruth Andrew; Doris N. Redhead; Fredrik Karpe; Peter C. Hayes; Tommy Olsson; Brian R. Walker
Topics:
hydrocortisone
,
cortisone
,
portal vein
,
oxidoreductase
Diabetes January 2009, Vol.58, 46-53. doi:https://doi.org/10.2337/db08-0969
Retinol-Binding Protein 4 in Twins: Regulatory Mechanisms and Impact of Circulating and Tissue Expression Levels on Insulin Secretion and Action
Topics:
obesity
,
plasma
,
rna, messenger
,
skeletal muscles
,
twins
Diabetes January 2009, Vol.58, 54-60. doi:https://doi.org/10.2337/db08-1019
Adiponectin Upregulates Ferritin Heavy Chain in Skeletal Muscle Cells
Yuichi Ikegami; Kouichi Inukai; Kenta Imai; Yasushi Sakamoto; Hideki Katagiri; Susumu Kurihara; Takuya Awata; Shigehiro Katayama
Topics:
adiponectin
,
skeletal myocytes
Diabetes January 2009, Vol.58, 61-70. doi:https://doi.org/10.2337/db07-0690
Mid- and Late-Life Diabetes in Relation to the Risk of Dementia: A Population-Based Twin Study
Topics:
dementia
,
twins
,
alzheimer's disease
,
middle-aged adult
Diabetes January 2009, Vol.58, 71-77. doi:https://doi.org/10.2337/db08-0586
Restoration of Hepatic Glucokinase Expression Corrects Hepatic Glucose Flux and Normalizes Plasma Glucose in Zucker Diabetic Fatty Rats
Tracy P. Torres; ReEtta L. Catlin; Robert Chan; Yuka Fujimoto; Noriyasu Sasaki; Richard L. Printz; Christopher B. Newgard; Masakazu Shiota
Topics:
glucose
,
hyperglycemic agents
,
liver
,
plasma glucose
,
rats
Diabetes January 2009, Vol.58, 78-86. doi:https://doi.org/10.2337/db08-1119
Xenin, a Gastrointestinal Peptide, Regulates Feeding Independent of the Melanocortin Signaling Pathway
Topics:
eating
,
intraperitoneal injections
,
mice
,
loss of appetite
,
peptides
Diabetes January 2009, Vol.58, 87-94. doi:https://doi.org/10.2337/db08-0260
Signal Transduction
Hypoxia Decreases Insulin Signaling Pathways in Adipocytes
Claire Regazzetti; Pascal Peraldi; Thierry Grémeaux; Rosanna Najem-Lendom; Issam Ben-Sahra; Mireille Cormont; Frédéric Bost; Yannick Le Marchand-Brustel; Jean-François Tanti; Sophie Giorgetti-Peraldi
Topics:
adipocytes
,
hypoxia
,
insulin
,
insulin receptor
Diabetes January 2009, Vol.58, 95-103. doi:https://doi.org/10.2337/db08-0457
Obesity Studies
Obesity-Related Upregulation of Monocyte Chemotactic Factors in Adipocytes : Involvement of Nuclear Factor-κB and c-Jun NH2-Terminal Kinase Pathways
Topics:
adipocytes
,
chemokines
,
chemotactic factors
,
monocyte chemoattractant protein-1
,
monocytes
Diabetes January 2009, Vol.58, 104-115. doi:https://doi.org/10.2337/db07-1344
Elevated Expression of Osteopontin May Be Related to Adipose Tissue Macrophage Accumulation and Liver Steatosis in Morbid Obesity
Adeline Bertola; Vanessa Deveaux; Stéphanie Bonnafous; Déborah Rousseau; Rodolphe Anty; Abdelilah Wakkach; Moncef Dahman; Joan Tordjman; Karine Clément; Siobhán E. McQuaid; Keith N. Frayn; Pierre-Michel Huet; Jean Gugenheim; Sophie Lotersztajn; Yannick Le Marchand-Brustel; Albert Tran; Philippe Gual
Topics:
adipose tissue
,
cd44 antigens
,
fatty liver
,
gene expression
,
homing-associated cell adhesion molecule
Diabetes January 2009, Vol.58, 125-133. doi:https://doi.org/10.2337/db08-0400
Association of Parental Obesity With Concentrations of Select Systemic Biomarkers in Nonobese Offspring : The Framingham Heart Study
Wolfgang Lieb; Michael J. Pencina; Katherine J. Lanier; Geoffrey H. Tofler; Daniel Levy; Caroline S. Fox; Thomas J. Wang; Ralph B. D'Agostino, Sr.; Ramachandran S. Vasan
Topics:
biological markers
,
obesity
,
c-reactive protein
Diabetes January 2009, Vol.58, 134-137. doi:https://doi.org/10.2337/db08-0918
Original Article
Obesity Studies
Skeletal Muscle–Specific Deletion of Lipoprotein Lipase Enhances Insulin Signaling in Skeletal Muscle but Causes Insulin Resistance in Liver and Other Tissues
Hong Wang; Leslie A. Knaub; Dalan R. Jensen; Dae Young Jung; Eun-Gyoung Hong; Hwi-Jin Ko; Alison M. Coates; Ira J. Goldberg; Becky A. de la Houssaye; Rachel C. Janssen; Carrie E. McCurdy; Shaikh M. Rahman; Cheol Soo Choi; Gerald I. Shulman; Jason K. Kim; Jacob E. Friedman; Robert H. Eckel
Topics:
insulin
,
lipids
,
mice
,
skeletal muscles
,
liver
Diabetes October 2008, Vol.58, 116-124. doi:https://doi.org/10.2337/db07-1839
Immunology and Transplantation
Plasmacytoid Dendritic Cells Are Proportionally Expanded at Diagnosis of Type 1 Diabetes and Enhance Islet Autoantigen Presentation to T-Cells Through Immune Complex Capture
Jennifer S. Allen; Karl Pang; Ania Skowera; Richard Ellis; Chloe Rackham; Biliana Lozanoska-Ochser; Timothy Tree; R. David G. Leslie; Jennifer M. Tremble; Colin M. Dayan; Mark Peakman
Topics:
dendritic cells
,
diabetes mellitus, type 1
,
autoantigens
Diabetes January 2009, Vol.58, 138-145. doi:https://doi.org/10.2337/db08-0964
All-trans Retinoic Acid Inhibits Type 1 Diabetes by T Regulatory (Treg)-Dependent Suppression of Interferon-γ–Producing T-cells Without Affecting Th17 Cells
Topics:
t-lymphocytes
,
tretinoin
,
mice
,
diabetes mellitus, type 1
,
regulatory t-lymphocytes
Diabetes January 2009, Vol.58, 146-155. doi:https://doi.org/10.2337/db08-1154
Slc11a1 Enhances the Autoimmune Diabetogenic T-Cell Response by Altering Processing and Presentation of Pancreatic Islet Antigens
Topics:
antigen processing and presentation
,
antigens
,
mice
,
molecule
,
t-lymphocytes
Diabetes January 2009, Vol.58, 156-164. doi:https://doi.org/10.2337/db07-1608
Idd Loci Synergize to Prolong Islet Allograft Survival Induced by Costimulation Blockade in NOD Mice
Julie Mangada; Todd Pearson; Michael A. Brehm; Linda S. Wicker; Laurence B. Peterson; Leonard D. Shultz; David V. Serreze; Aldo A. Rossini; Dale L. Greiner
Topics:
allografting
,
interleukin-2
,
lymphocyte costimulation
,
mice
,
mice, inbred nod
Diabetes January 2009, Vol.58, 165-173. doi:https://doi.org/10.2337/db08-0275
Islet Studies
Regulation of Calcium-Permeable TRPV2 Channel by Insulin in Pancreatic β-Cells
Topics:
calcium
,
insulin
,
translocation (genetics)
,
glucose
,
insulin secretion
Diabetes January 2009, Vol.58, 174-184. doi:https://doi.org/10.2337/db08-0862
Methyltransferase Set7/9 Maintains Transcription and Euchromatin Structure at Islet-Enriched Genes
Topics:
genes
,
rna, small interfering
,
mice
,
transfection
,
glucose
Diabetes January 2009, Vol.58, 185-193. doi:https://doi.org/10.2337/db08-1150
Pathophysiology
Portal Vein Glucose Sensors Do Not Play a Major Role in Modulating Physiological Responses to Insulin-Induced Hypoglycemia in Humans
Paolo Rossetti; Francesca Porcellati; Paola Lucidi; Natalia Busciantella Ricci; Paola Candeloro; Patrizia Cioli; Fausto Santeusanio; Geremia B. Bolli; Carmine G. Fanelli
Topics:
glucose
,
hypoglycemia
,
insulin
,
sensor
,
plasma glucose
Diabetes January 2009, Vol.58, 194-202. doi:https://doi.org/10.2337/db08-0641
Hepatic Stearoyl-CoA Desaturase (SCD)-1 Activity and Diacylglycerol but Not Ceramide Concentrations Are Increased in the Nonalcoholic Human Fatty Liver
Anna Kotronen; Tuulikki Seppänen-Laakso; Jukka Westerbacka; Tuula Kiviluoto; Johanna Arola; Anna-Liisa Ruskeepää; Matej Orešič; Hannele Yki-Järvinen
Topics:
ceramides
,
diglycerides
,
fatty acids
,
fatty liver
,
lipids
Diabetes January 2009, Vol.58, 203-208. doi:https://doi.org/10.2337/db08-1074
Complications
Vessel Shrinkage as a Sign of Atherosclerosis Progression in Type 2 Diabetes : A Serial Intravascular Ultrasound Analysis
Pilar Jiménez-Quevedo; Nobuaki Suzuki; Cecilia Corros; Cruz Ferrer; Dominick J. Angiolillo; Fernando Alfonso; Rosana Hernández-Antolín; Camino Bañuelos; Javier Escaned; Cristina Fernández; Marco Costa; Carlos Macaya; Theodore Bass; Manel Sabaté
Topics:
intravascular ultrasonography
,
atherosclerosis
,
diabetes mellitus, type 2
,
follow-up
,
revascularization
Diabetes January 2009, Vol.58, 209-214. doi:https://doi.org/10.2337/db08-0376
Rho Kinase Inhibition by Fasudil Ameliorates Diabetes-Induced Microvascular Damage
Ryoichi Arita; Yasuaki Hata; Shintaro Nakao; Takeshi Kita; Muneki Miura; Shuhei Kawahara; Souska Zandi; Lama Almulki; Faryan Tayyari; Hiroaki Shimokawa; Ali Hafezi-Moghadam; Tatsuro Ishibashi
Topics:
apoptosis
,
endothelium
,
neutrophils
,
retina
,
diabetic retinopathy
Diabetes January 2009, Vol.58, 215-226. doi:https://doi.org/10.2337/db08-0762
Role of Glyceraldehyde 3-Phosphate Dehydrogenase in the Development and Progression of Diabetic Retinopathy
Topics:
diabetic retinopathy
,
histopathology tests
,
hyperglycemia
,
rats
,
retina
Diabetes January 2009, Vol.58, 227-234. doi:https://doi.org/10.2337/db08-1025
Pharmacology & Therapeutics
Insulin Reduces Cerebral Ischemia/Reperfusion Injury in the Hippocampus of Diabetic Rats: A Role for Glycogen Synthase Kinase-3β
Massimo Collino; Manuela Aragno; Sara Castiglia; Chiara Tomasinelli; Christoph Thiemermann; Giuseppe Boccuzzi; Roberto Fantozzi
Topics:
insulin
,
rats
,
reperfusion therapy
,
hippocampus
,
streptozocin
Diabetes January 2009, Vol.58, 235-242. doi:https://doi.org/10.2337/db08-0691
Inhibition of Dipeptidyl Peptidase-4 by Vildagliptin During Glucagon-Like Peptide 1 Infusion Increases Liver Glucose Uptake in the Conscious Dog
Dale S. Edgerton; Kathryn M.S. Johnson; Doss W. Neal; Melanie Scott; Charles H. Hobbs; Xia Zhang; Alokesh Duttaroy; Alan D. Cherrington
Topics:
dog, domestic
,
glucagon-like peptide 1
,
glucose
,
vildagliptin
,
plasma
Diabetes January 2009, Vol.58, 243-249. doi:https://doi.org/10.2337/db08-0515
Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice
Jing Xu; David J. Lloyd; Clarence Hale; Shanaka Stanislaus; Michelle Chen; Glenn Sivits; Steven Vonderfecht; Randy Hecht; Yue-Sheng Li; Richard A. Lindberg; Jin-Long Chen; Dae Young Jung; Zhiyou Zhang; Hwi-Jin Ko; Jason K. Kim; Murielle M. Véniant
Topics:
diet
,
diet, high-fat
,
energy metabolism
,
fatty liver
,
glucose
Diabetes January 2009, Vol.58, 250-259. doi:https://doi.org/10.2337/db08-0392
Genetics
Genome-Wide Linkage Scan in Gullah-Speaking African American Families With Type 2 Diabetes: The Sea Islands Genetic African American Registry (Project SuGAR)
Michèle M. Sale; Lingyi Lu; Ida J. Spruill; Jyotika K. Fernandes; Kerry H. Lok; Jasmin Divers; Carl D. Langefeld; W. Timothy Garvey
Topics:
diabetes mellitus, type 2
,
genome
,
sugars
,
genetics
,
logistic regression
Diabetes January 2009, Vol.58, 260-267. doi:https://doi.org/10.2337/db08-0198
Interleukin-6 Receptor Gene, Plasma C-Reactive Protein, and Diabetes Risk in Women
Topics:
c-reactive protein
,
interleukin-6
,
plasma
,
genes
,
single nucleotide polymorphism
Diabetes January 2009, Vol.58, 275-278. doi:https://doi.org/10.2337/db08-0968
Genome-Wide Linkage Scan for Genes Influencing Plasma Triglyceride Levels in the Veterans Administration Genetic Epidemiology Study
Dawn K. Coletta; Jennifer Schneider; Shirley L. Hu; Thomas D. Dyer; Sobha Puppala; Vidya S. Farook; Rector Arya; Donna M. Lehman; John Blangero; Ralph A. DeFronzo; Ravindranath Duggirala; Christopher P. Jenkinson
Topics:
genes
,
genetic linkage analysis
,
genome
,
plasma triglycerides
,
triglycerides
Diabetes January 2009, Vol.58, 279-284. doi:https://doi.org/10.2337/db08-0491
Transcription Factor 7-Like 2 (TCF7L2) Polymorphism and Context-Specific Risk of Type 2 Diabetes in African American and Caucasian Adults: The Atherosclerosis Risk in Communities Study
Yu Yan; Kari E. North; Christie M. Ballantyne; Frederick L. Brancati; Lloyd E. Chambless; Nora Franceschini; Gerardo Heiss; Anna Kottgen; James S. Pankow; Elizabeth Selvin; Suzanne L. West; Eric Boerwinkle
Topics:
aric trial
,
chief complaint
,
diabetes mellitus, type 2
,
obesity
,
tcf7l2 gene
Diabetes January 2009, Vol.58, 285-289. doi:https://doi.org/10.2337/db08-0569
Follow-Up Analysis of Genome-Wide Association Data Identifies Novel Loci for Type 1 Diabetes
Struan F.A. Grant; Hui-Qi Qu; Jonathan P. Bradfield; Luc Marchand; Cecilia E. Kim; Joseph T. Glessner; Rosemarie Grabs; Shayne P. Taback; Edward C. Frackelton; Andrew W. Eckert; Kiran Annaiah; Margaret L. Lawson; F. George Otieno; Erin Santa; Julie L. Shaner; Ryan M. Smith; Robert Skraban; Marcin Imielinski; Rosetta M. Chiavacci; Robert W. Grundmeier; Charles A. Stanley; Susan E. Kirsch; Daryl Waggott; Andrew D. Paterson; Dimitri S. Monos; the DCCT/EDIC Research Group; Constantin Polychronakos; Hakon Hakonarson
Diabetes January 2009, Vol.58, 290-295. doi:https://doi.org/10.2337/db08-1022
Online Letters
Response to Comment on: Klöting et al. (2008) Autocrine IGF-1 Action in Adipocytes Controls Systemic IGF-1 Concentrations and Growth: Diabetes 57:2074–2082
Topics:
adipocytes
,
autocrine
,
insulin-like growth factor i
,
insulin-like-growth factor i receptor
Diabetes January 2009, Vol.58, e4. doi:https://doi.org/10.2337/db08-1442
