Issues

Topics: clinical research , conflict of interest , decision making , diabetes mellitus complications , eye

Diabetes January 2009, Vol.58, 1. doi:https://doi.org/10.2337/db08-1395

OSA Lecture 2008

Can We Learn From Viruses How to Prevent Type 1 Diabetes?: The Role of Viral Infections in the Pathogenesis of Type 1 Diabetes and the Development of Novel Combination Therapies

Matthias von Herrath

Abstracts

Topics: diabetes mellitus, type 1 , virus diseases , antigens

Diabetes January 2009, Vol.58, 2-11. doi:https://doi.org/10.2337/db08-9027

Commentaries

Role of Plasmacytoid Dendritic Cells in Type 1 Diabetes: Friend or Foe?

Roland Tisch; Bo Wang

Abstracts

Topics: dendritic cells , diabetes mellitus, type 1 , t-lymphocytes

Diabetes January 2009, Vol.58, 12-13. doi:https://doi.org/10.2337/db08-1341

Selective Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 for Patients With Metabolic Syndrome: Is the Target Liver, Fat, or Both?

Paul M. Stewart; Jeremy W. Tomlinson

Abstracts

Topics: hydrocortisone , hydroxysteroids , liver , metabolic syndrome x , oxidoreductase

Diabetes January 2009, Vol.58, 14-15. doi:https://doi.org/10.2337/db08-1404

Fat Partitioning and Insulin Sensitivity: Robbing Peter to Pay Paul?

Matthew J. Watt; Edward W. Kraegen

Abstracts

Topics: fatty acids , insulin resistance , insulin sensitivity , lipoprotein lipase , triglycerides

Diabetes January 2009, Vol.58, 16-17. doi:https://doi.org/10.2337/db08-1466

Targeting Hepatic Glucokinase in Type 2 Diabetes: Weighing the Benefits and Risks

Loranne Agius

Abstracts

Topics: diabetes mellitus, type 2 , glucokinase , glucose

Diabetes January 2009, Vol.58, 18-20. doi:https://doi.org/10.2337/db08-1470

Hypoglycemic Detection at the Portal Vein: Absent in Humans or Yet to Be Elucidated?

Casey M. Donovan; MaryAnn Bohland

Abstracts

Topics: hypoglycemic agents , portal vein , glucose

Diabetes January 2009, Vol.58, 21-23. doi:https://doi.org/10.2337/db08-1437

Taking a Daily Vitamin to Prevent Type 1 Diabetes?

Clive Wasserfall; Mark A. Atkinson

Abstracts

Topics: diabetes mellitus, type 1 , vitamins

Diabetes January 2009, Vol.58, 24-25. doi:https://doi.org/10.2337/db08-1479

Breathing Room: The (Un)Natural History of Adipose Microhypoxia and Insulin Resistance

Kyle D. Copps; Morris F. White

Abstracts

Topics: inspiration , insulin resistance , obesity , respiration , hypoxia

Diabetes January 2009, Vol.58, 26-27. doi:https://doi.org/10.2337/db08-1517

Sleeping Beauty, Awake! Regulation of Insulin Gene Expression by Methylation of Histone H3

Douglas R. Cavener

Abstracts

Topics: histone h3 , insulin , methylation , sleep , beauty

Diabetes January 2009, Vol.58, 28-29. doi:https://doi.org/10.2337/db08-1520

New Methodologies and Databases

Increased Secretion and Expression of Myostatin in Skeletal Muscle From Extremely Obese Women

Dustin S. Hittel; Jason R. Berggren; Jane Shearer; Kristen Boyle; Joseph A. Houmard

Abstracts

Topics: bodily secretions , culture media, conditioned , obesity, morbid , skeletal muscles , skeletal myocytes

Diabetes January 2009, Vol.58, 30-38. doi:https://doi.org/10.2337/db08-0943

Metabolism

Liver Is the Site of Splanchnic Cortisol Production in Obese Nondiabetic Humans

Rita Basu; Ananda Basu; Meagan Grudzien; Paul Jung; Peer Jacobson; Michael Johnson; Ravinder Singh; Michael Sarr; Robert A. Rizza

Abstracts

Topics: hydrocortisone , liver , viscera , obesity , cortisone

Diabetes January 2009, Vol.58, 39-45. doi:https://doi.org/10.2337/db08-1079

Cortisol Release From Adipose Tissue by 11β-Hydroxysteroid Dehydrogenase Type 1 in Humans

Roland H. Stimson; Jonas Andersson; Ruth Andrew; Doris N. Redhead; Fredrik Karpe; Peter C. Hayes; Tommy Olsson; Brian R. Walker

Abstracts

Topics: hydrocortisone , cortisone , portal vein , oxidoreductase

Diabetes January 2009, Vol.58, 46-53. doi:https://doi.org/10.2337/db08-0969

Retinol-Binding Protein 4 in Twins: Regulatory Mechanisms and Impact of Circulating and Tissue Expression Levels on Insulin Secretion and Action

Rasmus Ribel-Madsen; Martin Friedrichsen; Allan Vaag; Pernille Poulsen

Abstracts

Topics: obesity , plasma , rna, messenger , skeletal muscles , twins

Diabetes January 2009, Vol.58, 54-60. doi:https://doi.org/10.2337/db08-1019

Adiponectin Upregulates Ferritin Heavy Chain in Skeletal Muscle Cells

Yuichi Ikegami; Kouichi Inukai; Kenta Imai; Yasushi Sakamoto; Hideki Katagiri; Susumu Kurihara; Takuya Awata; Shigehiro Katayama

Abstracts

Topics: adiponectin , skeletal myocytes

Diabetes January 2009, Vol.58, 61-70. doi:https://doi.org/10.2337/db07-0690

Mid- and Late-Life Diabetes in Relation to the Risk of Dementia: A Population-Based Twin Study

Weili Xu; Chengxuan Qiu; Margaret Gatz; Nancy L. Pedersen; Boo Johansson; Laura Fratiglioni

Abstracts

Topics: dementia , twins , alzheimer's disease , middle-aged adult

Diabetes January 2009, Vol.58, 71-77. doi:https://doi.org/10.2337/db08-0586

Restoration of Hepatic Glucokinase Expression Corrects Hepatic Glucose Flux and Normalizes Plasma Glucose in Zucker Diabetic Fatty Rats

Tracy P. Torres; ReEtta L. Catlin; Robert Chan; Yuka Fujimoto; Noriyasu Sasaki; Richard L. Printz; Christopher B. Newgard; Masakazu Shiota

Abstracts

Topics: glucose , hyperglycemic agents , liver , plasma glucose , rats

Diabetes January 2009, Vol.58, 78-86. doi:https://doi.org/10.2337/db08-1119

Xenin, a Gastrointestinal Peptide, Regulates Feeding Independent of the Melanocortin Signaling Pathway

Arnold Leckstrom; Eun Ran Kim; Davie Wong; Tooru M. Mizuno

Abstracts

Topics: eating , intraperitoneal injections , mice , loss of appetite , peptides

Diabetes January 2009, Vol.58, 87-94. doi:https://doi.org/10.2337/db08-0260

Signal Transduction

Hypoxia Decreases Insulin Signaling Pathways in Adipocytes

Claire Regazzetti; Pascal Peraldi; Thierry Grémeaux; Rosanna Najem-Lendom; Issam Ben-Sahra; Mireille Cormont; Frédéric Bost; Yannick Le Marchand-Brustel; Jean-François Tanti; Sophie Giorgetti-Peraldi

Abstracts

Topics: adipocytes , hypoxia , insulin , insulin receptor

Diabetes January 2009, Vol.58, 95-103. doi:https://doi.org/10.2337/db08-0457

Obesity Studies

Obesity-Related Upregulation of Monocyte Chemotactic Factors in Adipocytes : Involvement of Nuclear Factor-κB and c-Jun NH₂-Terminal Kinase Pathways

Ping Jiao; Qiu Chen; Suketu Shah; Jing Du; Bo Tao; Iphigenia Tzameli; Weiqun Yan; Haiyan Xu

Abstracts

Topics: adipocytes , chemokines , chemotactic factors , monocyte chemoattractant protein-1 , monocytes

Diabetes January 2009, Vol.58, 104-115. doi:https://doi.org/10.2337/db07-1344

Elevated Expression of Osteopontin May Be Related to Adipose Tissue Macrophage Accumulation and Liver Steatosis in Morbid Obesity

Adeline Bertola; Vanessa Deveaux; Stéphanie Bonnafous; Déborah Rousseau; Rodolphe Anty; Abdelilah Wakkach; Moncef Dahman; Joan Tordjman; Karine Clément; Siobhán E. McQuaid; Keith N. Frayn; Pierre-Michel Huet; Jean Gugenheim; Sophie Lotersztajn; Yannick Le Marchand-Brustel; Albert Tran; Philippe Gual

Abstracts

Topics: adipose tissue , cd44 antigens , fatty liver , gene expression , homing-associated cell adhesion molecule

Diabetes January 2009, Vol.58, 125-133. doi:https://doi.org/10.2337/db08-0400

Association of Parental Obesity With Concentrations of Select Systemic Biomarkers in Nonobese Offspring : The Framingham Heart Study

Wolfgang Lieb; Michael J. Pencina; Katherine J. Lanier; Geoffrey H. Tofler; Daniel Levy; Caroline S. Fox; Thomas J. Wang; Ralph B. D'Agostino, Sr.; Ramachandran S. Vasan

Abstracts

Topics: biological markers , obesity , c-reactive protein

Diabetes January 2009, Vol.58, 134-137. doi:https://doi.org/10.2337/db08-0918

Original Article

Obesity Studies

Skeletal Muscle–Specific Deletion of Lipoprotein Lipase Enhances Insulin Signaling in Skeletal Muscle but Causes Insulin Resistance in Liver and Other Tissues

Hong Wang; Leslie A. Knaub; Dalan R. Jensen; Dae Young Jung; Eun-Gyoung Hong; Hwi-Jin Ko; Alison M. Coates; Ira J. Goldberg; Becky A. de la Houssaye; Rachel C. Janssen; Carrie E. McCurdy; Shaikh M. Rahman; Cheol Soo Choi; Gerald I. Shulman; Jason K. Kim; Jacob E. Friedman; Robert H. Eckel

Abstracts

Topics: insulin , lipids , mice , skeletal muscles , liver

Diabetes October 2008, Vol.58, 116-124. doi:https://doi.org/10.2337/db07-1839

Immunology and Transplantation

Plasmacytoid Dendritic Cells Are Proportionally Expanded at Diagnosis of Type 1 Diabetes and Enhance Islet Autoantigen Presentation to T-Cells Through Immune Complex Capture

Jennifer S. Allen; Karl Pang; Ania Skowera; Richard Ellis; Chloe Rackham; Biliana Lozanoska-Ochser; Timothy Tree; R. David G. Leslie; Jennifer M. Tremble; Colin M. Dayan; Mark Peakman

Abstracts

Topics: dendritic cells , diabetes mellitus, type 1 , autoantigens

Diabetes January 2009, Vol.58, 138-145. doi:https://doi.org/10.2337/db08-0964

All-trans Retinoic Acid Inhibits Type 1 Diabetes by T Regulatory (Treg)-Dependent Suppression of Interferon-γ–Producing T-cells Without Affecting Th17 Cells

Yang-Hau Van; Wen-Hui Lee; Serina Ortiz; Mi-Heon Lee; Han-Jun Qin; Chih-Pin Liu

Abstracts

Topics: t-lymphocytes , tretinoin , mice , diabetes mellitus, type 1 , regulatory t-lymphocytes

Diabetes January 2009, Vol.58, 146-155. doi:https://doi.org/10.2337/db08-1154

Slc11a1 Enhances the Autoimmune Diabetogenic T-Cell Response by Altering Processing and Presentation of Pancreatic Islet Antigens

Yang D. Dai; Idania G. Marrero; Philippe Gros; Habib Zaghouani; Linda S. Wicker; Eli E. Sercarz

Abstracts

Topics: antigen processing and presentation , antigens , mice , molecule , t-lymphocytes

Diabetes January 2009, Vol.58, 156-164. doi:https://doi.org/10.2337/db07-1608

Idd Loci Synergize to Prolong Islet Allograft Survival Induced by Costimulation Blockade in NOD Mice

Julie Mangada; Todd Pearson; Michael A. Brehm; Linda S. Wicker; Laurence B. Peterson; Leonard D. Shultz; David V. Serreze; Aldo A. Rossini; Dale L. Greiner

Abstracts

Topics: allografting , interleukin-2 , lymphocyte costimulation , mice , mice, inbred nod

Diabetes January 2009, Vol.58, 165-173. doi:https://doi.org/10.2337/db08-0275

Islet Studies

Regulation of Calcium-Permeable TRPV2 Channel by Insulin in Pancreatic β-Cells

Etsuko Hisanaga; Masahiro Nagasawa; Kohjiro Ueki; Rohit N. Kulkarni; Masatomo Mori; Itaru Kojima

Abstracts

Topics: calcium , insulin , translocation (genetics) , glucose , insulin secretion

Diabetes January 2009, Vol.58, 174-184. doi:https://doi.org/10.2337/db08-0862

Methyltransferase Set7/9 Maintains Transcription and Euchromatin Structure at Islet-Enriched Genes

Tye G. Deering; Takeshi Ogihara; Anthony P. Trace; Bernhard Maier; Raghavendra G. Mirmira

Abstracts

Topics: genes , rna, small interfering , mice , transfection , glucose

Diabetes January 2009, Vol.58, 185-193. doi:https://doi.org/10.2337/db08-1150

Pathophysiology

Portal Vein Glucose Sensors Do Not Play a Major Role in Modulating Physiological Responses to Insulin-Induced Hypoglycemia in Humans

Paolo Rossetti; Francesca Porcellati; Paola Lucidi; Natalia Busciantella Ricci; Paola Candeloro; Patrizia Cioli; Fausto Santeusanio; Geremia B. Bolli; Carmine G. Fanelli

Abstracts

Topics: glucose , hypoglycemia , insulin , sensor , plasma glucose

Diabetes January 2009, Vol.58, 194-202. doi:https://doi.org/10.2337/db08-0641

Hepatic Stearoyl-CoA Desaturase (SCD)-1 Activity and Diacylglycerol but Not Ceramide Concentrations Are Increased in the Nonalcoholic Human Fatty Liver

Anna Kotronen; Tuulikki Seppänen-Laakso; Jukka Westerbacka; Tuula Kiviluoto; Johanna Arola; Anna-Liisa Ruskeepää; Matej Orešič; Hannele Yki-Järvinen

Abstracts

Topics: ceramides , diglycerides , fatty acids , fatty liver , lipids

Diabetes January 2009, Vol.58, 203-208. doi:https://doi.org/10.2337/db08-1074

Complications

Vessel Shrinkage as a Sign of Atherosclerosis Progression in Type 2 Diabetes : A Serial Intravascular Ultrasound Analysis

Pilar Jiménez-Quevedo; Nobuaki Suzuki; Cecilia Corros; Cruz Ferrer; Dominick J. Angiolillo; Fernando Alfonso; Rosana Hernández-Antolín; Camino Bañuelos; Javier Escaned; Cristina Fernández; Marco Costa; Carlos Macaya; Theodore Bass; Manel Sabaté

Abstracts

Topics: intravascular ultrasonography , atherosclerosis , diabetes mellitus, type 2 , follow-up , revascularization

Diabetes January 2009, Vol.58, 209-214. doi:https://doi.org/10.2337/db08-0376

Rho Kinase Inhibition by Fasudil Ameliorates Diabetes-Induced Microvascular Damage

Ryoichi Arita; Yasuaki Hata; Shintaro Nakao; Takeshi Kita; Muneki Miura; Shuhei Kawahara; Souska Zandi; Lama Almulki; Faryan Tayyari; Hiroaki Shimokawa; Ali Hafezi-Moghadam; Tatsuro Ishibashi

Abstracts

Topics: apoptosis , endothelium , neutrophils , retina , diabetic retinopathy

Diabetes January 2009, Vol.58, 215-226. doi:https://doi.org/10.2337/db08-0762

Role of Glyceraldehyde 3-Phosphate Dehydrogenase in the Development and Progression of Diabetic Retinopathy

Mamta Kanwar; Renu A. Kowluru

Abstracts

Topics: diabetic retinopathy , histopathology tests , hyperglycemia , rats , retina

Diabetes January 2009, Vol.58, 227-234. doi:https://doi.org/10.2337/db08-1025

Pharmacology & Therapeutics

Insulin Reduces Cerebral Ischemia/Reperfusion Injury in the Hippocampus of Diabetic Rats: A Role for Glycogen Synthase Kinase-3β

Massimo Collino; Manuela Aragno; Sara Castiglia; Chiara Tomasinelli; Christoph Thiemermann; Giuseppe Boccuzzi; Roberto Fantozzi

Abstracts

Topics: insulin , rats , reperfusion therapy , hippocampus , streptozocin

Diabetes January 2009, Vol.58, 235-242. doi:https://doi.org/10.2337/db08-0691

Inhibition of Dipeptidyl Peptidase-4 by Vildagliptin During Glucagon-Like Peptide 1 Infusion Increases Liver Glucose Uptake in the Conscious Dog

Dale S. Edgerton; Kathryn M.S. Johnson; Doss W. Neal; Melanie Scott; Charles H. Hobbs; Xia Zhang; Alokesh Duttaroy; Alan D. Cherrington

Abstracts

Topics: dog, domestic , glucagon-like peptide 1 , glucose , vildagliptin , plasma

Diabetes January 2009, Vol.58, 243-249. doi:https://doi.org/10.2337/db08-0515

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

Jing Xu; David J. Lloyd; Clarence Hale; Shanaka Stanislaus; Michelle Chen; Glenn Sivits; Steven Vonderfecht; Randy Hecht; Yue-Sheng Li; Richard A. Lindberg; Jin-Long Chen; Dae Young Jung; Zhiyou Zhang; Hwi-Jin Ko; Jason K. Kim; Murielle M. Véniant

Abstracts

Topics: diet , diet, high-fat , energy metabolism , fatty liver , glucose

Diabetes January 2009, Vol.58, 250-259. doi:https://doi.org/10.2337/db08-0392

Genetics

Genome-Wide Linkage Scan in Gullah-Speaking African American Families With Type 2 Diabetes: The Sea Islands Genetic African American Registry (Project SuGAR)

Michèle M. Sale; Lingyi Lu; Ida J. Spruill; Jyotika K. Fernandes; Kerry H. Lok; Jasmin Divers; Carl D. Langefeld; W. Timothy Garvey

Abstracts

Topics: diabetes mellitus, type 2 , genome , sugars , genetics , logistic regression

Diabetes January 2009, Vol.58, 260-267. doi:https://doi.org/10.2337/db08-0198

Genome-Wide Linkage and Admixture Mapping of Type 2 Diabetes in African American Families From the American Diabetes Association GENNID (Genetics of NIDDM) Study Cohort

Steven C. Elbein; Swapan K. Das; D. Michael Hallman; Craig L. Hanis; Sandra J. Hasstedt

Abstracts

Topics: diabetes mellitus, type 2 , genome , single nucleotide polymorphism

Diabetes January 2009, Vol.58, 268-274. doi:https://doi.org/10.2337/db08-0931

Interleukin-6 Receptor Gene, Plasma C-Reactive Protein, and Diabetes Risk in Women

Lu Qi; Nader Rifai; Frank B. Hu

Abstracts

Topics: c-reactive protein , interleukin-6 , plasma , genes , single nucleotide polymorphism

Diabetes January 2009, Vol.58, 275-278. doi:https://doi.org/10.2337/db08-0968

Genome-Wide Linkage Scan for Genes Influencing Plasma Triglyceride Levels in the Veterans Administration Genetic Epidemiology Study

Dawn K. Coletta; Jennifer Schneider; Shirley L. Hu; Thomas D. Dyer; Sobha Puppala; Vidya S. Farook; Rector Arya; Donna M. Lehman; John Blangero; Ralph A. DeFronzo; Ravindranath Duggirala; Christopher P. Jenkinson

Abstracts

Topics: genes , genetic linkage analysis , genome , plasma triglycerides , triglycerides

Diabetes January 2009, Vol.58, 279-284. doi:https://doi.org/10.2337/db08-0491

Transcription Factor 7-Like 2 (TCF7L2) Polymorphism and Context-Specific Risk of Type 2 Diabetes in African American and Caucasian Adults: The Atherosclerosis Risk in Communities Study

Yu Yan; Kari E. North; Christie M. Ballantyne; Frederick L. Brancati; Lloyd E. Chambless; Nora Franceschini; Gerardo Heiss; Anna Kottgen; James S. Pankow; Elizabeth Selvin; Suzanne L. West; Eric Boerwinkle

Abstracts

Topics: aric trial , chief complaint , diabetes mellitus, type 2 , obesity , tcf7l2 gene

Diabetes January 2009, Vol.58, 285-289. doi:https://doi.org/10.2337/db08-0569

Follow-Up Analysis of Genome-Wide Association Data Identifies Novel Loci for Type 1 Diabetes

Abstracts

Topics: diabetes mellitus, type 1 , dcct trial , genotype determination

Diabetes January 2009, Vol.58, 290-295. doi:https://doi.org/10.2337/db08-1022

Online Letters

Comment on: Barker et al. (2008) Two Single Nucleotide Polymorphisms Identify the Highest-Risk Diabetes HLA Genotype: Diabetes 57:3152–3155, 2008

Jihane Romanos; Cisca Wijmenga

Abstracts

Topics: genotype , human leukocyte antigens , single nucleotide polymorphism

Diabetes January 2009, Vol.58, e1. doi:https://doi.org/10.2337/db08-1312

Response to Comment on: Barker et al. (2008) Two Single Nucleotide Polymorphisms Identify the Highest-Risk Diabetes HLA Genotype: Diabetes 57:3152–3155, 2008

Jennifer M. Barker; Taylor M. Triolo; George S. Eisenbarth

Abstracts

Topics: genotype , human leukocyte antigens , single nucleotide polymorphism

Diabetes January 2009, Vol.58, e2. doi:https://doi.org/10.2337/db08-1386

Comment on: Klöting et al. (2008) Autocrine IGF-1 Action in Adipocytes Controls Systemic IGF-1 Concentrations and Growth: Diabetes 57:2074–2082

Andrzej Bartke; John Kopchick

Abstracts

Topics: adipocytes , autocrine , insulin-like growth factor i

Diabetes January 2009, Vol.58, e3. doi:https://doi.org/10.2337/db08-1308

Response to Comment on: Klöting et al. (2008) Autocrine IGF-1 Action in Adipocytes Controls Systemic IGF-1 Concentrations and Growth: Diabetes 57:2074–2082

Jens C. Brüning; Matthias Blüher

Abstracts