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Volume 58, Issue 11
1 November 2009
Diabetes Cover Image for Volume 58, Issue 11
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ISSN 0012-1797
EISSN 1939-327X
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Editorials

Insulin Glargine Controversy: A Tribute to the Editorial Team at Diabetologia
Peter C. Butler
View articletitled, Insulin Glargine Controversy: A Tribute to the Editorial Team at <em>Diabetologia</em>
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Diabetes November 2009, Vol.58, 2427-2428. doi:https://doi.org/10.2337/db09-9030

Perspectives in Diabetes

Metabolomics Applied to Diabetes Research: Moving From Information to Knowledge
James R. Bain; Robert D. Stevens; Brett R. Wenner; Olga Ilkayeva; Deborah M. Muoio; Christopher B. Newgard
View articletitled, Metabolomics Applied to Diabetes Research<span class="subtitle-colon">: </span><span class="subtitle">Moving From Information to Knowledge</span>
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Diabetes November 2009, Vol.58, 2429-2443. doi:https://doi.org/10.2337/db09-0580

Commentaries

Novel Insights Into the Etiology of Diabetes From Genome-Wide Association Studies
Colin N.A. Palmer
View articletitled, Novel Insights Into the Etiology of Diabetes From Genome-Wide Association Studies
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Diabetes November 2009, Vol.58, 2444-2447. doi:https://doi.org/10.2337/db09-1153
Coronary Artery Calcium: A Clue to the Enigma of Tight Glycemic Control and Cardiovascular Disease?
Alain G. Bertoni; Dalane W. Kitzman
View articletitled, Coronary Artery Calcium: A Clue to the Enigma of Tight Glycemic Control and Cardiovascular Disease?
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Diabetes November 2009, Vol.58, 2448-2449. doi:https://doi.org/10.2337/db09-1097

Original Article

New Methodologies and Databases
C. elegans as Model for the Study of High Glucose– Mediated Life Span Reduction
Andreas Schlotterer; Georgi Kukudov; Farastuk Bozorgmehr; Harald Hutter; Xueliang Du; Dimitrios Oikonomou; Youssef Ibrahim; Friederike Pfisterer; Naila Rabbani; Paul Thornalley; Ahmed Sayed; Thomas Fleming; Per Humpert; Vedat Schwenger; Martin Zeier; Andreas Hamann; David Stern; Michael Brownlee; Angelika Bierhaus; Peter Nawroth; Michael Morcos
View articletitled, <em>C. elegans</em> as Model for the Study of High Glucose– Mediated Life Span Reduction
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Diabetes August 2009, Vol.58, 2450-2456. doi:https://doi.org/10.2337/db09-0567
Metabolism
Muscle Contraction, but Not Insulin, Increases Microvascular Blood Volume in the Presence of Free Fatty Acid–Induced Insulin Resistance
April C. Inyard; Daniel G. Chong; Alexander L. Klibanov; Eugene J. Barrett
View articletitled, Muscle Contraction, but Not Insulin, Increases Microvascular Blood Volume in the Presence of Free Fatty Acid–Induced Insulin Resistance
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Diabetes August 2009, Vol.58, 2457-2463. doi:https://doi.org/10.2337/db08-1077
Cleavage of Protein Kinase D After Acute Hypoinsulinemia Prevents Excessive Lipoprotein Lipase–Mediated Cardiac Triglyceride Accumulation
Min Suk Kim; Fang Wang; Prasanth Puthanveetil; Girish Kewalramani; Sheila Innis; Lucy Marzban; Susan F. Steinberg; Travis D. Webber; Timothy J. Kieffer; Ashraf Abrahani; Brian Rodrigues
View articletitled, Cleavage of Protein Kinase D After Acute Hypoinsulinemia Prevents Excessive Lipoprotein Lipase–Mediated Cardiac Triglyceride Accumulation
Supplementary data
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Diabetes November 2009, Vol.58, 2464-2475. doi:https://doi.org/10.2337/db09-0681
Hypermetabolism, Hyperphagia, and Reduced Adiposity in Tankyrase-Deficient Mice
Tsung-Yin J. Yeh; Kristina K. Beiswenger; Pingping Li; Krista E. Bolin; Ray M. Lee; Tsu-Shuen Tsao; Anne N. Murphy; Andrea L. Hevener; Nai-Wen Chi
View articletitled, Hypermetabolism, Hyperphagia, and Reduced Adiposity in Tankyrase-Deficient Mice
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Diabetes August 2009, Vol.58, 2476-2485. doi:https://doi.org/10.2337/db08-1781
Reductive Metabolism of AGE Precursors: A Metabolic Route for Preventing AGE Accumulation in Cardiovascular Tissue
Shahid P. Baba; Oleg A. Barski; Yonis Ahmed; Timothy E. O'Toole; Daniel J. Conklin; Aruni Bhatnagar; Sanjay Srivastava
View articletitled, Reductive Metabolism of AGE Precursors: A Metabolic Route for Preventing AGE Accumulation in Cardiovascular Tissue
Supplementary data
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Diabetes August 2009, Vol.58, 2486-2497. doi:https://doi.org/10.2337/db09-0375
Adipose Tissue Exosome-Like Vesicles Mediate Activation of Macrophage-Induced Insulin Resistance
Zhong-bin Deng; Anton Poliakov; Robert W. Hardy; Ronald Clements; Cunren Liu; Yuelong Liu; Jianhua Wang; Xiaoyu Xiang; Shuangqin Zhang; Xiaoying Zhuang; Spandan V. Shah; Dongmei Sun; Sue Michalek; William E. Grizzle; Timothy Garvey; Jim Mobley; Huang-Ge Zhang
View articletitled, Adipose Tissue Exosome-Like Vesicles Mediate Activation of Macrophage-Induced Insulin Resistance
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Diabetes August 2009, Vol.58, 2498-2505. doi:https://doi.org/10.2337/db09-0216
11β-Hydroxysteroid Dehydrogenase Type 1 Regulates Glucocorticoid-Induced Insulin Resistance in Skeletal Muscle
Stuart A. Morgan; Mark Sherlock; Laura L. Gathercole; Gareth G. Lavery; Carol Lenaghan; Iwona J. Bujalska; David Laber; Alice Yu; Gemma Convey; Rachel Mayers; Krisztina Hegyi; Jaswinder K. Sethi; Paul M. Stewart; David M. Smith; Jeremy W. Tomlinson
View articletitled, 11β-Hydroxysteroid Dehydrogenase Type 1 Regulates Glucocorticoid-Induced Insulin Resistance in Skeletal Muscle
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Diabetes August 2009, Vol.58, 2506-2515. doi:https://doi.org/10.2337/db09-0525
Paradoxical Coupling of Triglyceride Synthesis and Fatty Acid Oxidation in Skeletal Muscle Overexpressing DGAT1
Li Liu; Xiaojing Shi; Cheol Soo Choi; Gerald I. Shulman; Katherine Klaus; K. Sreekumaran Nair; Gary J. Schwartz; Yiying Zhang; Ira J. Goldberg; Yi-Hao Yu
View articletitled, Paradoxical Coupling of Triglyceride Synthesis and Fatty Acid Oxidation in Skeletal Muscle Overexpressing DGAT1
Supplementary data
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Diabetes August 2009, Vol.58, 2516-2524. doi:https://doi.org/10.2337/db08-1096
Interleukin-10 Prevents Diet-Induced Insulin Resistance by Attenuating Macrophage and Cytokine Response in Skeletal Muscle
Eun-Gyoung Hong; Hwi Jin Ko; You-Ree Cho; Hyo-Jeong Kim; Zhexi Ma; Tim Y. Yu; Randall H. Friedline; Evelyn Kurt-Jones; Robert Finberg; Matthew A. Fischer; Erica L. Granger; Christopher C. Norbury; Stephen D. Hauschka; William M. Philbrick; Chun-Geun Lee; Jack A. Elias; Jason K. Kim
View articletitled, Interleukin-10 Prevents Diet-Induced Insulin Resistance by Attenuating Macrophage and Cytokine Response in Skeletal Muscle
Supplementary data
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Diabetes August 2009, Vol.58, 2525-2535. doi:https://doi.org/10.2337/db08-1261
Nutrient Stress Activates Inflammation and Reduces Glucose Metabolism by Suppressing AMP-Activated Protein Kinase in the Heart
Hwi Jin Ko; Zhiyou Zhang; Dae Young Jung; John Y. Jun; Zhexi Ma; Kelly E. Jones; Sook Y. Chan; Jason K. Kim
View articletitled, Nutrient Stress Activates Inflammation and Reduces Glucose Metabolism by Suppressing AMP-Activated Protein Kinase in the Heart
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Diabetes August 2009, Vol.58, 2536-2546. doi:https://doi.org/10.2337/db08-1361
Enhancement of Muscle Mitochondrial Oxidative Capacity and Alterations in Insulin Action Are Lipid Species Dependent: Potent Tissue-Specific Effects of Medium-Chain Fatty Acids
Nigel Turner; Krit Hariharan; Jennifer TidAng; Georgia Frangioudakis; Susan M. Beale; Lauren E. Wright; Xiao Yi Zeng; Simon J. Leslie; Jing-Ya Li; Edward W. Kraegen; Gregory J. Cooney; Ji-Ming Ye
View articletitled, Enhancement of Muscle Mitochondrial Oxidative Capacity and Alterations in Insulin Action Are Lipid Species Dependent<span class="subtitle-colon">: </span><span class="subtitle">Potent Tissue-Specific Effects of Medium-Chain Fatty Acids</span>
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Diabetes August 2009, Vol.58, 2547-2554. doi:https://doi.org/10.2337/db09-0784
The microRNA Signature in Response to Insulin Reveals Its Implication in the Transcriptional Action of Insulin in Human Skeletal Muscle and the Role of a Sterol Regulatory Element–Binding Protein-1c/Myocyte Enhancer Factor 2C Pathway
Aurélie Granjon; Marie-Paule Gustin; Jennifer Rieusset; Etienne Lefai; Emmanuelle Meugnier; Isabelle Güller; Catherine Cerutti; Christian Paultre; Emmanuel Disse; Rémi Rabasa-Lhoret; Martine Laville; Hubert Vidal; Sophie Rome
View articletitled, The microRNA Signature in Response to Insulin Reveals Its Implication in the Transcriptional Action of Insulin in Human Skeletal Muscle and the Role of a Sterol Regulatory Element–Binding Protein-1c/Myocyte Enhancer Factor 2C Pathway
Supplementary data
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Diabetes August 2009, Vol.58, 2555-2564. doi:https://doi.org/10.2337/db09-0165
Obesity Studies
Atf4 Regulates Obesity, Glucose Homeostasis, and Energy Expenditure
Jin Seo; Edgardo S. Fortuno, III; Jae Myoung Suh; Drew Stenesen; Wei Tang; Elizabeth J. Parks; Christopher M. Adams; Tim Townes; Jonathan M. Graff
View articletitled, Atf4 Regulates Obesity, Glucose Homeostasis, and Energy Expenditure
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Diabetes August 2009, Vol.58, 2565-2573. doi:https://doi.org/10.2337/db09-0335
Regulatory Mechanisms for Adipose Tissue M1 and M2 Macrophages in Diet-Induced Obese Mice
Shiho Fujisaka; Isao Usui; Agussalim Bukhari; Masashi Ikutani; Takeshi Oya; Yukiko Kanatani; Koichi Tsuneyama; Yoshinori Nagai; Kiyoshi Takatsu; Masaharu Urakaze; Masashi Kobayashi; Kazuyuki Tobe
View articletitled, Regulatory Mechanisms for Adipose Tissue M1 and M2 Macrophages in Diet-Induced Obese Mice
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Diabetes August 2009, Vol.58, 2574-2582. doi:https://doi.org/10.2337/db08-1475
Brown Adipose Tissue and Seasonal Variation in Humans
Iain T.H. Au-Yong; Natasha Thorn; Rakesh Ganatra; Alan C. Perkins; Michael E. Symonds
View articletitled, Brown Adipose Tissue and Seasonal Variation in Humans
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Diabetes August 2009, Vol.58, 2583-2587. doi:https://doi.org/10.2337/db09-0833
Immunology and Transplantation
Validity and Reproducibility of Measurement of Islet Autoreactivity by T-Cell Assays in Subjects With Early Type 1 Diabetes
Kevan C. Herold; Barbara Brooks-Worrell; Jerry Palmer; H. Michael Dosch; Mark Peakman; Peter Gottlieb; Helena Reijonen; Sefina Arif; Lisa M. Spain; Clinton Thompson; John M. Lachin; the Type 1 Diabetes TrialNet Research Group
View articletitled, Validity and Reproducibility of Measurement of Islet Autoreactivity by T-Cell Assays in Subjects With Early Type 1 Diabetes
Supplementary data
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Diabetes August 2009, Vol.58, 2588-2595. doi:https://doi.org/10.2337/db09-0249
Islet Studies
Expression of the NH2-Terminal Fragment of RasGAP in Pancreatic β-Cells Increases Their Resistance to Stresses and Protects Mice From Diabetes
Jiang-Yan Yang; Jöel Walicki; Evrim Jaccard; Gilles Dubuis; Natasa Bulat; Jean-Pierre Hornung; Bernard Thorens; Christian Widmann
View articletitled, Expression of the NH<sub>2</sub>-Terminal Fragment of RasGAP in Pancreatic β-Cells Increases Their Resistance to Stresses and Protects Mice From Diabetes
Supplementary data
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Diabetes August 2009, Vol.58, 2596-2606. doi:https://doi.org/10.2337/db09-0104
Deletion of GPR40 Impairs Glucose-Induced Insulin Secretion In Vivo in Mice Without Affecting Intracellular Fuel Metabolism in Islets
Thierry Alquier; Marie-Line Peyot; Martin G. Latour; Melkam Kebede; Christina M. Sorensen; Stephane Gesta; C. Ronald Kahn; Richard D. Smith; Thomas L. Jetton; Thomas O. Metz; Marc Prentki; Vincent Poitout
View articletitled, Deletion of GPR40 Impairs Glucose-Induced Insulin Secretion In Vivo in Mice Without Affecting Intracellular Fuel Metabolism in Islets
Supplementary data
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Diabetes August 2009, Vol.58, 2607-2615. doi:https://doi.org/10.2337/db09-0362
Pathophysiology
Dissociation Between Fatty Liver and Insulin Resistance in Humans Carrying a Variant of the Patatin-Like Phospholipase 3 Gene
Konstantinos Kantartzis; Andreas Peter; Fausto Machicao; Jürgen Machann; Silvia Wagner; Ingmar Königsrainer; Alfred Königsrainer; Fritz Schick; Andreas Fritsche; Hans-Ulrich Häring; Norbert Stefan
View articletitled, Dissociation Between Fatty Liver and Insulin Resistance in Humans Carrying a Variant of the Patatin-Like Phospholipase 3 Gene
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Diabetes August 2009, Vol.58, 2616-2623. doi:https://doi.org/10.2337/db09-0279
FoxO1 Links Insulin Resistance to Proinflammatory Cytokine IL-1β Production in Macrophages
Dongming Su; Gina M. Coudriet; Dae Hyun Kim; Yi Lu; German Perdomo; Shen Qu; Sandra Slusher; Hubert M. Tse; Jon Piganelli; Nick Giannoukakis; Jian Zhang; H. Henry Dong
View articletitled, FoxO1 Links Insulin Resistance to Proinflammatory Cytokine IL-1β Production in Macrophages
Supplementary data
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Diabetes August 2009, Vol.58, 2624-2633. doi:https://doi.org/10.2337/db09-0232
Placental Structure in Type 1 Diabetes: Relation to Fetal Insulin, Leptin, and IGF-I
Scott M. Nelson; Philip M. Coan; Graham J. Burton; Robert S. Lindsay
View articletitled, Placental Structure in Type 1 Diabetes<span class="subtitle-colon">: </span><span class="subtitle">Relation to Fetal Insulin, Leptin, and IGF-I</span>
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Diabetes August 2009, Vol.58, 2634-2641. doi:https://doi.org/10.2337/db09-0739
Complications
Intensive Glucose-Lowering Therapy Reduces Cardiovascular Disease Events in Veterans Affairs Diabetes Trial Participants With Lower Calcified Coronary Atherosclerosis
Peter D. Reaven; Thomas E. Moritz; Dawn C. Schwenke; Robert J. Anderson; Michael Criqui; Robert Detrano; Nicholas Emanuele; Moti Kayshap; Jennifer Marks; Sunder Mudaliar; R. Harsha Rao; Jayendra H. Shah; Steven Goldman; Domenic J. Reda; Madeline McCarren; Carlos Abraira; William Duckworth; for the Veterans Affairs Diabetes Trial
View articletitled, Intensive Glucose-Lowering Therapy Reduces Cardiovascular Disease Events in Veterans Affairs Diabetes Trial Participants With Lower Calcified Coronary Atherosclerosis
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Diabetes August 2009, Vol.58, 2642-2648. doi:https://doi.org/10.2337/db09-0618
A1C Variability Predicts Incident Cardiovascular Events, Microalbuminuria, and Overt Diabetic Nephropathy in Patients With Type 1 Diabetes
Johan Wadén; Carol Forsblom; Lena M. Thorn; Daniel Gordin; Markku Saraheimo; Per-Henrik Groop; on behalf of the Finnish Diabetic Nephropathy Study Group
View articletitled, A1C Variability Predicts Incident Cardiovascular Events, Microalbuminuria, and Overt Diabetic Nephropathy in Patients With Type 1 Diabetes
Supplementary data
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Diabetes August 2009, Vol.58, 2649-2655. doi:https://doi.org/10.2337/db09-0693
Selective T-Type Calcium Channel Blockade Alleviates Hyperalgesia in ob/ob Mice
Janelle R. Latham; Sriyani Pathirathna; Miljen M. Jagodic; Won Joo Choe; Michaela E. Levin; Michael T. Nelson; Woo Yong Lee; Kathiresan Krishnan; Douglas F. Covey; Slobodan M. Todorovic; Vesna Jevtovic-Todorovic
View articletitled, Selective T-Type Calcium Channel Blockade Alleviates Hyperalgesia in <em>ob/ob</em> Mice
Supplementary data
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Diabetes August 2009, Vol.58, 2656-2665. doi:https://doi.org/10.2337/db08-1763
Vascular Endothelial Growth Factor Inhibition by dRK6 Causes Endothelial Apoptosis, Fibrosis, and Inflammation in the Heart via the Akt/eNOS Axis in db/db Mice
Cheol Whee Park; Hyung Wook Kim; Ji Hee Lim; Ki Dong Yoo; Sungjin Chung; Seok Joon Shin; Hyun Wha Chung; Sang Ju Lee; Chi-Bom Chae; Yong-Soo Kim; Yoon Sik Chang
View articletitled, Vascular Endothelial Growth Factor Inhibition by dRK6 Causes Endothelial Apoptosis, Fibrosis, and Inflammation in the Heart via the Akt/eNOS Axis in <em>db/db</em> Mice
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Diabetes August 2009, Vol.58, 2666-2676. doi:https://doi.org/10.2337/db09-0136
Caveolin-1 and Altered Neuregulin Signaling Contribute to the Pathophysiological Progression of Diabetic Peripheral Neuropathy
James F. McGuire; Shefali Rouen; Eric Siegfreid; Douglas E. Wright; Rick T. Dobrowsky
View articletitled, Caveolin-1 and Altered Neuregulin Signaling Contribute to the Pathophysiological Progression of Diabetic Peripheral Neuropathy
Supplementary data
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Diabetes August 2009, Vol.58, 2677-2686. doi:https://doi.org/10.2337/db09-0594
Genetics
Genetic Variant in HK1 Is Associated With a Proanemic State and A1C but Not Other Glycemic Control–Related Traits
Amélie Bonnefond; Martine Vaxillaire; Yann Labrune; Cécile Lecoeur; Jean-Claude Chèvre; Nabila Bouatia-Naji; Stéphane Cauchi; Beverley Balkau; Michel Marre; Jean Tichet; Jean-Pierre Riveline; Samy Hadjadj; Yves Gallois; Sébastien Czernichow; Serge Hercberg; Marika Kaakinen; Susanne Wiesner; Guillaume Charpentier; Claire Lévy-Marchal; Paul Elliott; Marjo-Riitta Jarvelin; Fritz Horber; Christian Dina; Oluf Pedersen; Robert Sladek; David Meyre; Philippe Froguel
View articletitled, Genetic Variant in <em>HK1</em> Is Associated With a Proanemic State and A1C but Not Other Glycemic Control–Related Traits
Supplementary data
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Diabetes August 2009, Vol.58, 2687-2697. doi:https://doi.org/10.2337/db09-0652
Confirmation of Genetic Associations at ELMO1 in the GoKinD Collection Supports Its Role as a Susceptibility Gene in Diabetic Nephropathy
Marcus G. Pezzolesi; Pisut Katavetin; Masahiko Kure; G. David Poznik; Jan Skupien; Josyf C. Mychaleckyj; Stephen S. Rich; James H. Warram; Andrzej S. Krolewski
View articletitled, Confirmation of Genetic Associations at <em>ELMO1</em> in the GoKinD Collection Supports Its Role as a Susceptibility Gene in Diabetic Nephropathy
Supplementary data
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Diabetes August 2009, Vol.58, 2698-2702. doi:https://doi.org/10.2337/db09-0641
Common Genetic Variation Near Melatonin Receptor MTNR1B Contributes to Raised Plasma Glucose and Increased Risk of Type 2 Diabetes Among Indian Asians and European Caucasians
John C. Chambers; Weihua Zhang; Delilah Zabaneh; Joban Sehmi; Piyush Jain; Mark I. McCarthy; Philippe Froguel; Aimo Ruokonen; David Balding; Marjo-Riitta Jarvelin; James Scott; Paul Elliott; Jaspal S. Kooner
View articletitled, Common Genetic Variation Near Melatonin Receptor <em>MTNR1B</em> Contributes to Raised Plasma Glucose and Increased Risk of Type 2 Diabetes Among Indian Asians and European Caucasians
Supplementary data
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Diabetes August 2009, Vol.58, 2703-2708. doi:https://doi.org/10.2337/db08-1805
Système International (SI) Units Table
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus
Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes: Many Differences, Few Similarities
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