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Commentaries

Regulating Glucagon Secretion: Somatostatin in the Spotlight

Guy A. Rutter

Abstracts

View articletitled, Regulating Glucagon Secretion: Somatostatin in the Spotlight

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Topics: glucagon , glucagon secretion , insulin , somatostatin , glucose

Diabetes February 2009, Vol.58, 299-301. doi:https://doi.org/10.2337/db08-1534

Many HAPO Returns: Maternal Glycemia and Neonatal Adiposity: New Insights from the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) Study

Robert S. Lindsay

Abstracts

View articletitled, Many HAPO Returns: Maternal Glycemia and Neonatal Adiposity: New Insights from the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) Study

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Topics: adverse pregnancy outcome , hapo trial , hyperglycemia , newborn , obesity

Diabetes February 2009, Vol.58, 302-303. doi:https://doi.org/10.2337/db08-1562

The α-Cell Conundrum: ATP-Sensitive K⁺ Channels and Glucose Sensing

David A. Jacobson; Barton L. Wicksteed; Louis H. Philipson

Abstracts

View articletitled, The α-Cell Conundrum: ATP-Sensitive K+ Channels and Glucose Sensing

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Topics: glucose

Diabetes February 2009, Vol.58, 304-306. doi:https://doi.org/10.2337/db08-1618

Inflammation, Insulin Resistance, and Type 2 Diabetes: Back to the Future?

William T. Cefalu

Abstracts

View articletitled, Inflammation, Insulin Resistance, and Type 2 Diabetes: Back to the Future?

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Topics: diabetes mellitus, type 2 , inflammation , insulin resistance , obesity

Diabetes February 2009, Vol.58, 307-308. doi:https://doi.org/10.2337/db08-1656

New Methodologies and Databases

Site-Specific GlcNAcylation of Human Erythrocyte Proteins: Potential Biomarker(s) for Diabetes

Zihao Wang; Kyoungsook Park; Frank Comer; Linda C. Hsieh-Wilson; Christopher D. Saudek; Gerald W. Hart

Abstracts

View articletitled, Site-Specific GlcNAcylation of Human Erythrocyte Proteins: Potential Biomarker(s) for Diabetes

Supplementary data

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Topics: erythrocytes , peptides , mass spectrometry , biological markers , dose fractionation

Diabetes February 2009, Vol.58, 309-317. doi:https://doi.org/10.2337/db08-0994

Metabolism

Exendin-4 Improves Glycemic Control, Ameliorates Brain and Pancreatic Pathologies, and Extends Survival in a Mouse Model of Huntington's Disease

Bronwen Martin; Erin Golden; Olga D. Carlson; Paul Pistell; Jie Zhou; Wook Kim; Brittany P. Frank; Sam Thomas; Wayne A. Chadwick; Nigel H. Greig; Gillian P. Bates; Kirupa Sathasivam; Michel Bernier; Stuart Maudsley; Mark P. Mattson; Josephine M. Egan

Abstracts

View articletitled, Exendin-4 Improves Glycemic Control, Ameliorates Brain and Pancreatic Pathologies, and Extends Survival in a Mouse Model of Huntington's Disease

Supplementary data

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Topics: huntington's disease , mice , insulin , pancreas , hormones

Diabetes February 2009, Vol.58, 318-328. doi:https://doi.org/10.2337/db08-0799

Imatinib Mesylate Reduces Endoplasmic Reticulum Stress and Induces Remission of Diabetes in db/db Mice

Myoung Sook Han; Kun Wook Chung; Hyae Gyeong Cheon; Sang Dal Rhee; Chang-Hwan Yoon; Moon-Kyu Lee; Kwang-Won Kim; Myung-Shik Lee

Abstracts

View articletitled, Imatinib Mesylate Reduces Endoplasmic Reticulum Stress and Induces Remission of Diabetes in db/db Mice

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Topics: endoplasmic reticulum , imatinib mesylate , mice , stress , disease remission

Diabetes February 2009, Vol.58, 329-336. doi:https://doi.org/10.2337/db08-0080

Plasma Ceramides Are Elevated in Obese Subjects With Type 2 Diabetes and Correlate With the Severity of Insulin Resistance

Jacob M. Haus; Sangeeta R. Kashyap; Takhar Kasumov; Renliang Zhang; Karen R. Kelly; Ralph A. DeFronzo; John P. Kirwan

Abstracts

View articletitled, Plasma Ceramides Are Elevated in Obese Subjects With Type 2 Diabetes and Correlate With the Severity of Insulin Resistance

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Topics: ceramides , obesity , plasma , tumor necrosis factors , diabetes mellitus, type 2

Diabetes February 2009, Vol.58, 337-343. doi:https://doi.org/10.2337/db08-1228

Overexpression of SIRT1 Protects Pancreatic β-Cells Against Cytokine Toxicity by Suppressing the Nuclear Factor-κB Signaling Pathway

Ji-Hyun Lee; Mi-Young Song; Eun-Kyung Song; Eun-Kyung Kim; Woo Sung Moon; Myung-Kwan Han; Jin-Woo Park; Kang-Beom Kwon; Byung-Hyun Park

Abstracts

View articletitled, Overexpression of SIRT1 Protects Pancreatic β-Cells Against Cytokine Toxicity by Suppressing the Nuclear Factor-κB Signaling Pathway

Supplementary data

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Topics: cytokine , nitric oxide synthase , protein overexpression , toxic effect , pancreas

Diabetes February 2009, Vol.58, 344-351. doi:https://doi.org/10.2337/db07-1795

Exenatide Sensitizes Insulin-Mediated Whole-Body Glucose Disposal and Promotes Uptake of Exogenous Glucose by the Liver

Dan Zheng; Viorica Ionut; Vahe Mooradian; Darko Stefanovski; Richard N. Bergman

Abstracts

View articletitled, Exenatide Sensitizes Insulin-Mediated Whole-Body Glucose Disposal and Promotes Uptake of Exogenous Glucose by the Liver

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Topics: exenatide , glucose , hyperglycemia , hyperinsulinism , insulin

Diabetes February 2009, Vol.58, 352-359. doi:https://doi.org/10.2337/db08-0875

Antecedent Hypoglycemia Impairs Autonomic Cardiovascular Function: Implications for Rigorous Glycemic Control

Gail K. Adler; Istvan Bonyhay; Hannah Failing; Elizabeth Waring; Sarah Dotson; Roy Freeman

Abstracts

View articletitled, Antecedent Hypoglycemia Impairs Autonomic Cardiovascular Function: Implications for Rigorous Glycemic Control

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Topics: baroreflex , hypoglycemia , lower body negative pressure , stress , autonomic nervous system

Diabetes February 2009, Vol.58, 360-366. doi:https://doi.org/10.2337/db08-1153

Physical Inactivity Differentially Alters Dietary Oleate and Palmitate Trafficking

Audrey Bergouignan; Guy Trudel; Chantal Simon; Angèle Chopard; Dale A. Schoeller; Iman Momken; Susanne B. Votruba; Michel Desage; Graham C. Burdge; Guillemette Gauquelin-Koch; Sylvie Normand; Stéphane Blanc

Abstracts

View articletitled, Physical Inactivity Differentially Alters Dietary Oleate and Palmitate Trafficking

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Topics: bed rest , diet , lack of exercise , oxidation , palmitates

Diabetes February 2009, Vol.58, 367-376. doi:https://doi.org/10.2337/db08-0263

Signal Transduction

DOC2B: A Novel Syntaxin-4 Binding Protein Mediating Insulin-Regulated GLUT4 Vesicle Fusion in Adipocytes

Naofumi Fukuda; Masahiro Emoto; Yoshitaka Nakamori; Akihiko Taguchi; Sachiko Miyamoto; Shinsuke Uraki; Yoshitomo Oka; Yukio Tanizawa

Abstracts

View articletitled, DOC2B: A Novel Syntaxin-4 Binding Protein Mediating Insulin-Regulated GLUT4 Vesicle Fusion in Adipocytes

Supplementary data

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Topics: adipocytes , insulin , vesicle , antibodies

Diabetes February 2009, Vol.58, 377-384. doi:https://doi.org/10.2337/db08-0303

Obesity Studies

Macrophage Content in Subcutaneous Adipose Tissue: Associations With Adiposity, Age, Inflammatory Markers, and Whole-Body Insulin Action in Healthy Pima Indians

Emilio Ortega Martinez de Victoria; Xiaoyuan Xu; Juraj Koska; Ann Marie Francisco; Michael Scalise; Anthony W. Ferrante, Jr.; Jonathan Krakoff

Abstracts

View articletitled, Macrophage Content in Subcutaneous Adipose Tissue: Associations With Adiposity, Age, Inflammatory Markers, and Whole-Body Insulin Action in Healthy Pima Indians

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Topics: adipose tissue , cd68 antigen, human , insulin , macrophages , obesity

Diabetes February 2009, Vol.58, 385-393. doi:https://doi.org/10.2337/db08-0536

Immunology and Transplantation

Recognition of Human Proinsulin Leader Sequence by Class I–Restricted T-Cells in HLA-A*0201 Transgenic Mice and in Human Type 1 Diabetes

Andréa Toma; Taghrid Laïka; Samy Haddouk; Sandrine Luce; Jean-Paul Briand; Luc Camoin; Francine Connan; Marion Lambert; Sophie Caillat-Zucman; Jean-Claude Carel; Sylviane Muller; Jeannine Choppin; François Lemonnier; Christian Boitard

Abstracts

View articletitled, Recognition of Human Proinsulin Leader Sequence by Class I–Restricted T-Cells in HLA-A*0201 Transgenic Mice and in Human Type 1 Diabetes

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Topics: hla-a2 antigen , peptides , preproinsulin , t-lymphocytes , proinsulin

Diabetes February 2009, Vol.58, 394-402. doi:https://doi.org/10.2337/db08-0599

Islet Studies

Somatostatin Secreted by Islet δ-Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function

Astrid C. Hauge-Evans; Aileen J. King; Danielle Carmignac; Carolyn C. Richardson; Iain C.A.F. Robinson; Malcolm J. Low; Michael R. Christie; Shanta J. Persaud; Peter M. Jones

Abstracts

View articletitled, Somatostatin Secreted by Islet δ-Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function

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Topics: glucagon secretion , glucose , insulin , insulin secretion , mice

Diabetes February 2009, Vol.58, 403-411. doi:https://doi.org/10.2337/db08-0792

Glucose and Pharmacological Modulators of ATP-Sensitive K⁺ Channels Control [Ca²⁺]_c by Different Mechanisms in Isolated Mouse α-Cells

Nicolas Quoix; Rui Cheng-Xue; Laurine Mattart; Ziad Zeinoun; Yves Guiot; Mélanie C. Beauvois; Jean-Claude Henquin; Patrick Gilon

Abstracts

View articletitled, Glucose and Pharmacological Modulators of ATP-Sensitive K+ Channels Control [Ca2+]c by Different Mechanisms in Isolated Mouse α-Cells

Supplementary data

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Topics: glucose , mice

Diabetes February 2009, Vol.58, 412-421. doi:https://doi.org/10.2337/db07-1298

Roles of IP₃R and RyR Ca²⁺ Channels in Endoplasmic Reticulum Stress and β-Cell Death

Dan S. Luciani; Kamila S. Gwiazda; Ting-Lin B. Yang; Tatyana B. Kalynyak; Yaryna Bychkivska; Matthew H.Z. Frey; Kristin D. Jeffrey; Arthur V. Sampaio; T. Michael Underhill; James D. Johnson

Abstracts

View articletitled, Roles of IP3R and RyR Ca2+ Channels in Endoplasmic Reticulum Stress and β-Cell Death

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Topics: emergency service, hospital , sarcoplasmic reticulum calcium-transporting atpases , stress , thapsigargin , apoptosis

Diabetes February 2009, Vol.58, 422-432. doi:https://doi.org/10.2337/db07-1762

A Role for von Hippel-Lindau Protein in Pancreatic β-Cell Function

Sapna Puri; David A. Cano; Matthias Hebrok

Abstracts

View articletitled, A Role for von Hippel-Lindau Protein in Pancreatic β-Cell Function

Supplementary data

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Topics: glucose , insulin , insulin secretion , mice , pancreas

Diabetes February 2009, Vol.58, 433-441. doi:https://doi.org/10.2337/db08-0749

Recovery of Endogenous β-Cell Function in Nonhuman Primates After Chemical Diabetes Induction and Islet Transplantation

Rita Bottino; Angela Criscimanna; Anna Casu; Jing He; Dirk J. Van der Windt; William A. Rudert; Carla Giordano; Massimo Trucco

Abstracts

View articletitled, Recovery of Endogenous β-Cell Function in Nonhuman Primates After Chemical Diabetes Induction and Islet Transplantation

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Topics: cercopithecidae , c-peptide , insulin , islets of langerhans transplantation , pancreas

Diabetes February 2009, Vol.58, 442-447. doi:https://doi.org/10.2337/db08-1127

Pathophysiology

Small Decrements in Systemic Glucose Provoke Increases in Hypothalamic Blood Flow Prior to the Release of Counterregulatory Hormones

Kathleen A. Page; Jagriti Arora; Maolin Qiu; Rachna Relwani; R. Todd Constable; Robert S. Sherwin

Abstracts

View articletitled, Small Decrements in Systemic Glucose Provoke Increases in Hypothalamic Blood Flow Prior to the Release of Counterregulatory Hormones

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Topics: brain , diagnostic imaging , functional magnetic resonance imaging , glucose , hormones

Diabetes February 2009, Vol.58, 448-452. doi:https://doi.org/10.2337/db08-1224

Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: Associations With Neonatal Anthropometrics

The HAPO Study Cooperative Research Group

Abstracts

View articletitled, Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: Associations With Neonatal Anthropometrics

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Topics: birth weight , body fat , c-peptide , glucose , hapo trial

Diabetes February 2009, Vol.58, 453-459. doi:https://doi.org/10.2337/db08-1112

Intergenerational Transmission of Glucose Intolerance and Obesity by In Utero Undernutrition in Mice

Josep C. Jimenez-Chillaron; Elvira Isganaitis; Marika Charalambous; Stephane Gesta; Thais Pentinat-Pelegrin; Ryan R. Faucette; Jessica P. Otis; Alice Chow; Ruben Diaz; Anne Ferguson-Smith; Mary-Elizabeth Patti

Abstracts

View articletitled, Intergenerational Transmission of Glucose Intolerance and Obesity by In Utero Undernutrition in Mice

Supplementary data

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Topics: genetic inheritance , glucose intolerance , mice , obesity , unilateral neglect

Diabetes February 2009, Vol.58, 460-468. doi:https://doi.org/10.2337/db08-0490

Complications

Enhanced Expression of Janus Kinase–Signal Transducer and Activator of Transcription Pathway Members in Human Diabetic Nephropathy

Celine C. Berthier; Hongyu Zhang; MaryLee Schin; Anna Henger; Robert G. Nelson; Berne Yee; Anissa Boucherot; Matthias A. Neusser; Clemens D. Cohen; Christin Carter-Su; Lawrence S. Argetsinger; Maria P. Rastaldi; Frank C. Brosius; Matthias Kretzler

Abstracts

View articletitled, Enhanced Expression of Janus Kinase–Signal Transducer and Activator of Transcription Pathway Members in Human Diabetic Nephropathy

Supplementary data

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Topics: diabetic nephropathy , mice , kidney glomerulus , reverse transcriptase polymerase chain reaction , mesangial cells

Diabetes February 2009, Vol.58, 469-477. doi:https://doi.org/10.2337/db08-1328

Genetics

Association Analysis of Variation in/Near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B With Type 2 Diabetes and Related Quantitative Traits in Pima Indians

Rong Rong; Robert L. Hanson; Daniel Ortiz; Christopher Wiedrich; Sayuko Kobes; William C. Knowler; Clifton Bogardus; Leslie J. Baier

Abstracts

View articletitled, Association Analysis of Variation in/Near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B With Type 2 Diabetes and Related Quantitative Traits in Pima Indians

Supplementary data

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Topics: cdkn2b gene , diabetes mellitus, type 2 , fto gene , insulin , single nucleotide polymorphism

Diabetes February 2009, Vol.58, 478-488. doi:https://doi.org/10.2337/db08-0877

A Single-Nucleotide Polymorphism in a Methylatable Foxa2 Binding Site of the G6PC2 Promoter Is Associated With Insulin Secretion In Vivo and Increased Promoter Activity In Vitro

Christine Dos Santos; Pierre Bougnères; Delphine Fradin

Abstracts

View articletitled, A Single-Nucleotide Polymorphism in a Methylatable Foxa2 Binding Site of the G6PC2 Promoter Is Associated With Insulin Secretion In Vivo and Increased Promoter Activity In Vitro

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Topics: alleles , binding sites , childhood obesity , electrophoretic mobility shift assay , fasting blood glucose measurement

Diabetes February 2009, Vol.58, 489-492. doi:https://doi.org/10.2337/db08-0587

Replication Study of Candidate Genes Associated With Type 2 Diabetes Based On Genome-Wide Screening

Yasuharu Tabara; Haruhiko Osawa; Ryuichi Kawamoto; Hiroshi Onuma; Ikki Shimizu; Tetsuro Miki; Katsuhiko Kohara; Hideichi Makino

Abstracts

View articletitled, Replication Study of Candidate Genes Associated With Type 2 Diabetes Based On Genome-Wide Screening

Supplementary data

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Topics: diabetes mellitus, type 2 , single nucleotide polymorphism , genomic screening , insulin , candidate disease gene

Diabetes February 2009, Vol.58, 493-498. doi:https://doi.org/10.2337/db07-1785

Association of Adiponectin Gene Polymorphisms With Type 2 Diabetes in an African American Population Enriched for Nephropathy

Meredith A. Bostrom; Barry I. Freedman; Carl D. Langefeld; Lingyi Liu; Pamela J. Hicks; Donald W. Bowden

Abstracts

View articletitled, Association of Adiponectin Gene Polymorphisms With Type 2 Diabetes in an African American Population Enriched for Nephropathy

Supplementary data

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Topics: adiponectin , diabetes mellitus, type 2 , diabetic nephropathy , kidney diseases , single nucleotide polymorphism

Diabetes February 2009, Vol.58, 499-504. doi:https://doi.org/10.2337/db08-0598

Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data

Nicholas J. Timpson; Cecilia M. Lindgren; Michael N. Weedon; Joshua Randall; Willem H. Ouwehand; David P. Strachan; N. William Rayner; Mark Walker; Graham A. Hitman; Alex S.F. Doney; Colin N.A. Palmer; Andrew D. Morris; Andrew T. Hattersley; Eleftheria Zeggini; Timothy M. Frayling; Mark I. McCarthy

Abstracts

View articletitled, Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data

Supplementary data

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Topics: diabetes mellitus, type 2 , heterogeneity , obesity , body mass index procedure , genome

Diabetes February 2009, Vol.58, 505-510. doi:https://doi.org/10.2337/db08-0906

Erratum

Extract

View articletitled, Erratum

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Topics: emergency service, hospital , endothelium , insulin resistance , walkers

Diabetes February 2009, Vol.58, 511. doi:https://doi.org/10.2337/db09-er02

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