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Issues

Volume 58, Issue 2
February 2009
Diabetes Cover Image for Volume 58, Issue 2
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ISSN 0012-1797
EISSN 1939-327X
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Commentaries

Regulating Glucagon Secretion: Somatostatin in the Spotlight
Guy A. Rutter
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Diabetes February 2009, Vol.58, 299-301. doi:https://doi.org/10.2337/db08-1534
Many HAPO Returns: Maternal Glycemia and Neonatal Adiposity: New Insights from the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) Study
Robert S. Lindsay
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Diabetes February 2009, Vol.58, 302-303. doi:https://doi.org/10.2337/db08-1562
The α-Cell Conundrum: ATP-Sensitive K+ Channels and Glucose Sensing
David A. Jacobson; Barton L. Wicksteed; Louis H. Philipson
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Diabetes February 2009, Vol.58, 304-306. doi:https://doi.org/10.2337/db08-1618
Inflammation, Insulin Resistance, and Type 2 Diabetes: Back to the Future?
William T. Cefalu
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Diabetes February 2009, Vol.58, 307-308. doi:https://doi.org/10.2337/db08-1656

New Methodologies and Databases

Site-Specific GlcNAcylation of Human Erythrocyte Proteins: Potential Biomarker(s) for Diabetes
Zihao Wang; Kyoungsook Park; Frank Comer; Linda C. Hsieh-Wilson; Christopher D. Saudek; Gerald W. Hart
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Diabetes February 2009, Vol.58, 309-317. doi:https://doi.org/10.2337/db08-0994

Metabolism

Exendin-4 Improves Glycemic Control, Ameliorates Brain and Pancreatic Pathologies, and Extends Survival in a Mouse Model of Huntington's Disease
Bronwen Martin; Erin Golden; Olga D. Carlson; Paul Pistell; Jie Zhou; Wook Kim; Brittany P. Frank; Sam Thomas; Wayne A. Chadwick; Nigel H. Greig; Gillian P. Bates; Kirupa Sathasivam; Michel Bernier; Stuart Maudsley; Mark P. Mattson; Josephine M. Egan
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Diabetes February 2009, Vol.58, 318-328. doi:https://doi.org/10.2337/db08-0799
Imatinib Mesylate Reduces Endoplasmic Reticulum Stress and Induces Remission of Diabetes in db/db Mice
Myoung Sook Han; Kun Wook Chung; Hyae Gyeong Cheon; Sang Dal Rhee; Chang-Hwan Yoon; Moon-Kyu Lee; Kwang-Won Kim; Myung-Shik Lee
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Diabetes February 2009, Vol.58, 329-336. doi:https://doi.org/10.2337/db08-0080
Plasma Ceramides Are Elevated in Obese Subjects With Type 2 Diabetes and Correlate With the Severity of Insulin Resistance
Jacob M. Haus; Sangeeta R. Kashyap; Takhar Kasumov; Renliang Zhang; Karen R. Kelly; Ralph A. DeFronzo; John P. Kirwan
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Diabetes February 2009, Vol.58, 337-343. doi:https://doi.org/10.2337/db08-1228
Overexpression of SIRT1 Protects Pancreatic β-Cells Against Cytokine Toxicity by Suppressing the Nuclear Factor-κB Signaling Pathway
Ji-Hyun Lee; Mi-Young Song; Eun-Kyung Song; Eun-Kyung Kim; Woo Sung Moon; Myung-Kwan Han; Jin-Woo Park; Kang-Beom Kwon; Byung-Hyun Park
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Diabetes February 2009, Vol.58, 344-351. doi:https://doi.org/10.2337/db07-1795
Exenatide Sensitizes Insulin-Mediated Whole-Body Glucose Disposal and Promotes Uptake of Exogenous Glucose by the Liver
Dan Zheng; Viorica Ionut; Vahe Mooradian; Darko Stefanovski; Richard N. Bergman
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Diabetes February 2009, Vol.58, 352-359. doi:https://doi.org/10.2337/db08-0875
Antecedent Hypoglycemia Impairs Autonomic Cardiovascular Function: Implications for Rigorous Glycemic Control
Gail K. Adler; Istvan Bonyhay; Hannah Failing; Elizabeth Waring; Sarah Dotson; Roy Freeman
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Diabetes February 2009, Vol.58, 360-366. doi:https://doi.org/10.2337/db08-1153
Physical Inactivity Differentially Alters Dietary Oleate and Palmitate Trafficking
Audrey Bergouignan; Guy Trudel; Chantal Simon; Angèle Chopard; Dale A. Schoeller; Iman Momken; Susanne B. Votruba; Michel Desage; Graham C. Burdge; Guillemette Gauquelin-Koch; Sylvie Normand; Stéphane Blanc
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Diabetes February 2009, Vol.58, 367-376. doi:https://doi.org/10.2337/db08-0263

Signal Transduction

DOC2B: A Novel Syntaxin-4 Binding Protein Mediating Insulin-Regulated GLUT4 Vesicle Fusion in Adipocytes
Naofumi Fukuda; Masahiro Emoto; Yoshitaka Nakamori; Akihiko Taguchi; Sachiko Miyamoto; Shinsuke Uraki; Yoshitomo Oka; Yukio Tanizawa
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Diabetes February 2009, Vol.58, 377-384. doi:https://doi.org/10.2337/db08-0303

Obesity Studies

Macrophage Content in Subcutaneous Adipose Tissue: Associations With Adiposity, Age, Inflammatory Markers, and Whole-Body Insulin Action in Healthy Pima Indians
Emilio Ortega Martinez de Victoria; Xiaoyuan Xu; Juraj Koska; Ann Marie Francisco; Michael Scalise; Anthony W. Ferrante, Jr.; Jonathan Krakoff
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Diabetes February 2009, Vol.58, 385-393. doi:https://doi.org/10.2337/db08-0536

Immunology and Transplantation

Recognition of Human Proinsulin Leader Sequence by Class I–Restricted T-Cells in HLA-A*0201 Transgenic Mice and in Human Type 1 Diabetes
Andréa Toma; Taghrid Laïka; Samy Haddouk; Sandrine Luce; Jean-Paul Briand; Luc Camoin; Francine Connan; Marion Lambert; Sophie Caillat-Zucman; Jean-Claude Carel; Sylviane Muller; Jeannine Choppin; François Lemonnier; Christian Boitard
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Diabetes February 2009, Vol.58, 394-402. doi:https://doi.org/10.2337/db08-0599

Islet Studies

Somatostatin Secreted by Islet δ-Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function
Astrid C. Hauge-Evans; Aileen J. King; Danielle Carmignac; Carolyn C. Richardson; Iain C.A.F. Robinson; Malcolm J. Low; Michael R. Christie; Shanta J. Persaud; Peter M. Jones
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Diabetes February 2009, Vol.58, 403-411. doi:https://doi.org/10.2337/db08-0792
Glucose and Pharmacological Modulators of ATP-Sensitive K+ Channels Control [Ca2+]c by Different Mechanisms in Isolated Mouse α-Cells
Nicolas Quoix; Rui Cheng-Xue; Laurine Mattart; Ziad Zeinoun; Yves Guiot; Mélanie C. Beauvois; Jean-Claude Henquin; Patrick Gilon
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Diabetes February 2009, Vol.58, 412-421. doi:https://doi.org/10.2337/db07-1298
Roles of IP3R and RyR Ca2+ Channels in Endoplasmic Reticulum Stress and β-Cell Death
Dan S. Luciani; Kamila S. Gwiazda; Ting-Lin B. Yang; Tatyana B. Kalynyak; Yaryna Bychkivska; Matthew H.Z. Frey; Kristin D. Jeffrey; Arthur V. Sampaio; T. Michael Underhill; James D. Johnson
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Diabetes February 2009, Vol.58, 422-432. doi:https://doi.org/10.2337/db07-1762
A Role for von Hippel-Lindau Protein in Pancreatic β-Cell Function
Sapna Puri; David A. Cano; Matthias Hebrok
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Diabetes February 2009, Vol.58, 433-441. doi:https://doi.org/10.2337/db08-0749
Recovery of Endogenous β-Cell Function in Nonhuman Primates After Chemical Diabetes Induction and Islet Transplantation
Rita Bottino; Angela Criscimanna; Anna Casu; Jing He; Dirk J. Van der Windt; William A. Rudert; Carla Giordano; Massimo Trucco
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Diabetes February 2009, Vol.58, 442-447. doi:https://doi.org/10.2337/db08-1127

Pathophysiology

Small Decrements in Systemic Glucose Provoke Increases in Hypothalamic Blood Flow Prior to the Release of Counterregulatory Hormones
Kathleen A. Page; Jagriti Arora; Maolin Qiu; Rachna Relwani; R. Todd Constable; Robert S. Sherwin
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Diabetes February 2009, Vol.58, 448-452. doi:https://doi.org/10.2337/db08-1224
Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: Associations With Neonatal Anthropometrics
The HAPO Study Cooperative Research Group
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Diabetes February 2009, Vol.58, 453-459. doi:https://doi.org/10.2337/db08-1112
Intergenerational Transmission of Glucose Intolerance and Obesity by In Utero Undernutrition in Mice
Josep C. Jimenez-Chillaron; Elvira Isganaitis; Marika Charalambous; Stephane Gesta; Thais Pentinat-Pelegrin; Ryan R. Faucette; Jessica P. Otis; Alice Chow; Ruben Diaz; Anne Ferguson-Smith; Mary-Elizabeth Patti
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Diabetes February 2009, Vol.58, 460-468. doi:https://doi.org/10.2337/db08-0490

Complications

Enhanced Expression of Janus Kinase–Signal Transducer and Activator of Transcription Pathway Members in Human Diabetic Nephropathy
Celine C. Berthier; Hongyu Zhang; MaryLee Schin; Anna Henger; Robert G. Nelson; Berne Yee; Anissa Boucherot; Matthias A. Neusser; Clemens D. Cohen; Christin Carter-Su; Lawrence S. Argetsinger; Maria P. Rastaldi; Frank C. Brosius; Matthias Kretzler
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Diabetes February 2009, Vol.58, 469-477. doi:https://doi.org/10.2337/db08-1328

Genetics

Association Analysis of Variation in/Near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B With Type 2 Diabetes and Related Quantitative Traits in Pima Indians
Rong Rong; Robert L. Hanson; Daniel Ortiz; Christopher Wiedrich; Sayuko Kobes; William C. Knowler; Clifton Bogardus; Leslie J. Baier
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Diabetes February 2009, Vol.58, 478-488. doi:https://doi.org/10.2337/db08-0877
A Single-Nucleotide Polymorphism in a Methylatable Foxa2 Binding Site of the G6PC2 Promoter Is Associated With Insulin Secretion In Vivo and Increased Promoter Activity In Vitro
Christine Dos Santos; Pierre Bougnères; Delphine Fradin
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Diabetes February 2009, Vol.58, 489-492. doi:https://doi.org/10.2337/db08-0587
Replication Study of Candidate Genes Associated With Type 2 Diabetes Based On Genome-Wide Screening
Yasuharu Tabara; Haruhiko Osawa; Ryuichi Kawamoto; Hiroshi Onuma; Ikki Shimizu; Tetsuro Miki; Katsuhiko Kohara; Hideichi Makino
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Diabetes February 2009, Vol.58, 493-498. doi:https://doi.org/10.2337/db07-1785
Association of Adiponectin Gene Polymorphisms With Type 2 Diabetes in an African American Population Enriched for Nephropathy
Meredith A. Bostrom; Barry I. Freedman; Carl D. Langefeld; Lingyi Liu; Pamela J. Hicks; Donald W. Bowden
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Diabetes February 2009, Vol.58, 499-504. doi:https://doi.org/10.2337/db08-0598
Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data
Nicholas J. Timpson; Cecilia M. Lindgren; Michael N. Weedon; Joshua Randall; Willem H. Ouwehand; David P. Strachan; N. William Rayner; Mark Walker; Graham A. Hitman; Alex S.F. Doney; Colin N.A. Palmer; Andrew D. Morris; Andrew T. Hattersley; Eleftheria Zeggini; Timothy M. Frayling; Mark I. McCarthy
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Diabetes February 2009, Vol.58, 505-510. doi:https://doi.org/10.2337/db08-0906

Erratum

Erratum
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Diabetes February 2009, Vol.58, 511. doi:https://doi.org/10.2337/db09-er02
Système International (SI) Units Table
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus
Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes: Many Differences, Few Similarities
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