Skip Nav Destination

Issues

Select Decade

Select Year

Issue

Search within issue:

Search within issue

Commentary

Commentaries

GPR40: Good Cop, Bad Cop?

Thierry Alquier; Vincent Poitout

Abstracts

View articletitled, GPR40: Good Cop, Bad Cop?

Open the PDF for in another window

Topics: agonists , diabetes mellitus, type 2 , diet, high-fat , fatty acids , glucose tolerance

Diabetes May 2009, Vol.58, 1035-1036. doi:https://doi.org/10.2337/db09-0215

Adipose Tissue Plasticity in Catch-Up–Growth Trajectories to Metabolic Syndrome: Hyperplastic Versus Hypertrophic Catch-Up Fat

Abdul G. Dulloo

Abstracts

View articletitled, Adipose Tissue Plasticity in Catch-Up–Growth Trajectories to Metabolic Syndrome: Hyperplastic Versus Hypertrophic Catch-Up Fat

Open the PDF for in another window

Topics: adipose tissue , hyperplasia , metabolic syndrome x , hyperinsulinism , insulin resistance

Diabetes May 2009, Vol.58, 1037-1039. doi:https://doi.org/10.2337/db09-0290

Original Article

Metabolism

Liver-Specific Loss of Lipolysis-Stimulated Lipoprotein Receptor Triggers Systemic Hyperlipidemia in Mice

Prachiti Narvekar; Mauricio Berriel Diaz; Anja Krones-Herzig; Ulrike Hardeland; Daniela Strzoda; Sigrid Stöhr; Marcus Frohme; Stephan Herzig

Abstracts

View articletitled, Liver-Specific Loss of Lipolysis-Stimulated Lipoprotein Receptor Triggers Systemic Hyperlipidemia in Mice

Supplementary data

Open the PDF for in another window

Topics: lipids , lipoprotein receptor , lipoproteins, vldl , liver , mice

Diabetes February 2009, Vol.58, 1040-1049. doi:https://doi.org/10.2337/db08-1184

MicroRNAs Induced During Adipogenesis that Accelerate Fat Cell Development Are Downregulated in Obesity

Huangming Xie; Bing Lim; Harvey F. Lodish

Abstracts

View articletitled, MicroRNAs Induced During Adipogenesis that Accelerate Fat Cell Development Are Downregulated in Obesity

Supplementary data

Open the PDF for in another window

Topics: adipocytes , micrornas , obesity

Diabetes February 2009, Vol.58, 1050-1057. doi:https://doi.org/10.2337/db08-1299

GPR119 Is Essential for Oleoylethanolamide-Induced Glucagon-Like Peptide-1 Secretion From the Intestinal Enteroendocrine L-Cell

Lina M. Lauffer; Roman Iakoubov; Patricia L. Brubaker

Abstracts

View articletitled, GPR119 Is Essential for Oleoylethanolamide-Induced Glucagon-Like Peptide-1 Secretion From the Intestinal Enteroendocrine L-Cell

Open the PDF for in another window

Topics: bodily secretions , glucagon-like peptide 1 , l cells (cell line) , intestines

Diabetes February 2009, Vol.58, 1058-1066. doi:https://doi.org/10.2337/db08-1237

Overexpression of GPR40 in Pancreatic β-Cells Augments Glucose-Stimulated Insulin Secretion and Improves Glucose Tolerance in Normal and Diabetic Mice

Kae Nagasumi; Ritsuko Esaki; Kimihiko Iwachidow; Yoshitaka Yasuhara; Kazuhiro Ogi; Hideyuki Tanaka; Mitsugu Nakata; Takashi Yano; Kozo Shimakawa; Shigehisa Taketomi; Koji Takeuchi; Hiroyuki Odaka; Yoshihiko Kaisho

Abstracts

View articletitled, Overexpression of GPR40 in Pancreatic β-Cells Augments Glucose-Stimulated Insulin Secretion and Improves Glucose Tolerance in Normal and Diabetic Mice

Open the PDF for in another window

Topics: diet, high-fat , glucose , glucose tolerance , insulin , insulin secretion

Diabetes February 2009, Vol.58, 1067-1076. doi:https://doi.org/10.2337/db08-1233

Signal Transduction

High Glucose Suppresses Epidermal Growth Factor Receptor/Phosphatidylinositol 3-Kinase/Akt Signaling Pathway and Attenuates Corneal Epithelial Wound Healing

Ke-Ping Xu; Yanfeng Li; Alexander V. Ljubimov; Fu-Shin X. Yu

Abstracts

View articletitled, High Glucose Suppresses Epidermal Growth Factor Receptor/Phosphatidylinositol 3-Kinase/Akt Signaling Pathway and Attenuates Corneal Epithelial Wound Healing

Open the PDF for in another window

Topics: 1-phosphatidylinositol 3-kinase , cornea , epidermal growth factor receptors , epithelium , glucose

Diabetes February 2009, Vol.58, 1077-1085. doi:https://doi.org/10.2337/db08-0997

Interleukin-6 Attenuates Insulin-Mediated Increases in Endothelial Cell Signaling but Augments Skeletal Muscle Insulin Action via Differential Effects on Tumor Necrosis Factor-α Expression

Derek Y.C. Yuen; Renee M. Dwyer; Vance B. Matthews; Lei Zhang; Brian G. Drew; Bronwyn Neill; Bronwyn A. Kingwell; Michael G. Clark; Stephen Rattigan; Mark A. Febbraio

Abstracts

View articletitled, Interleukin-6 Attenuates Insulin-Mediated Increases in Endothelial Cell Signaling but Augments Skeletal Muscle Insulin Action via Differential Effects on Tumor Necrosis Factor-α Expression

Supplementary data

Open the PDF for in another window

Topics: insulin , interleukin-6 , signal transduction

Diabetes February 2009, Vol.58, 1086-1095. doi:https://doi.org/10.2337/db08-0775

Inhibition of Contraction-Stimulated AMP-Activated Protein Kinase Inhibits Contraction-Stimulated Increases in PAS-TBC1D1 and Glucose Transport Without Altering PAS-AS160 in Rat Skeletal Muscle

Katsuhiko Funai; Gregory D. Cartee

Abstracts

View articletitled, Inhibition of Contraction-Stimulated AMP-Activated Protein Kinase Inhibits Contraction-Stimulated Increases in PAS-TBC1D1 and Glucose Transport Without Altering PAS-AS160 in Rat Skeletal Muscle

Open the PDF for in another window

Topics: ampk , glucose transport , immunoblotting , insulin , phosphorylation

Diabetes February 2009, Vol.58, 1096-1104. doi:https://doi.org/10.2337/db08-1477

Degradation of cAMP-Responsive Element–Binding Protein by the Ubiquitin-Proteasome Pathway Contributes to Glucotoxicity in β-Cells and Human Pancreatic Islets

Safia Costes; Brigitte Vandewalle; Cécile Tourrel-Cuzin; Christophe Broca; Nathalie Linck; Gyslaine Bertrand; Julie Kerr-Conte; Bernard Portha; François Pattou; Joel Bockaert; Stéphane Dalle

Abstracts

View articletitled, Degradation of cAMP-Responsive Element–Binding Protein by the Ubiquitin-Proteasome Pathway Contributes to Glucotoxicity in β-Cells and Human Pancreatic Islets

Open the PDF for in another window

Topics: cyclic amp-responsive dna-binding protein , glucose , peptides , apoptosis , catabolism

Diabetes February 2009, Vol.58, 1105-1115. doi:https://doi.org/10.2337/db08-0926

Obesity Studies

Prenatal Stress or High-Fat Diet Increases Susceptibility to Diet-Induced Obesity in Rat Offspring

Kellie L.K. Tamashiro; Chantelle E. Terrillion; Jayson Hyun; James I. Koenig; Timothy H. Moran

Abstracts

View articletitled, Prenatal Stress or High-Fat Diet Increases Susceptibility to Diet-Induced Obesity in Rat Offspring

Open the PDF for in another window

Topics: diet , diet, high-fat , obesity , stress , prenatal care

Diabetes February 2009, Vol.58, 1116-1125. doi:https://doi.org/10.2337/db08-1129

Weight Loss May Reverse Blunted Sympathetic Neural Responsiveness to Glucose Ingestion in Obese Subjects With Metabolic Syndrome

Nora E. Straznicky; Gavin W. Lambert; Mariee T. McGrane; Kazuko Masuo; Tye Dawood; Paul J. Nestel; Nina Eikelis; Markus P. Schlaich; Murray D. Esler; Florentia Socratous; Reena Chopra; Elisabeth A. Lambert

Abstracts

View articletitled, Weight Loss May Reverse Blunted Sympathetic Neural Responsiveness to Glucose Ingestion in Obese Subjects With Metabolic Syndrome

Open the PDF for in another window

Topics: glucose , insulin , metabolic syndrome x , norepinephrine , obesity

Diabetes February 2009, Vol.58, 1126-1132. doi:https://doi.org/10.2337/db08-1595

Loss-of-Function Mutation in Myostatin Reduces Tumor Necrosis Factor α Production and Protects Liver Against Obesity-Induced Insulin Resistance

Jason J. Wilkes; David J. Lloyd; Nick Gekakis

Abstracts

View articletitled, Loss-of-Function Mutation in Myostatin Reduces Tumor Necrosis Factor α Production and Protects Liver Against Obesity-Induced Insulin Resistance

Supplementary data

Open the PDF for in another window

Topics: insulin , insulin resistance , liver , mice , obesity

Diabetes February 2009, Vol.58, 1133-1143. doi:https://doi.org/10.2337/db08-0245

Immunology and Transplantation

Interleukin-21 Is Required for the Development of Type 1 Diabetes in NOD Mice

Andrew P.R. Sutherland; Tom Van Belle; Andrea L. Wurster; Akira Suto; Monia Michaud; Dorothy Zhang; Michael J. Grusby; Matthias von Herrath

Abstracts

View articletitled, Interleukin-21 Is Required for the Development of Type 1 Diabetes in NOD Mice

Supplementary data

Open the PDF for in another window

Topics: diabetes mellitus, type 1 , insulin , interleukin-21 , mice , mice, inbred nod

Diabetes February 2009, Vol.58, 1144-1155. doi:https://doi.org/10.2337/db08-0882

Activation of Insulin-Reactive CD8 T-Cells for Development of Autoimmune Diabetes

F. Susan Wong; Lai Khai Siew; Gwen Scott; Ian J. Thomas; Stephen Chapman; Christophe Viret; Li Wen

Abstracts

View articletitled, Activation of Insulin-Reactive CD8 T-Cells for Development of Autoimmune Diabetes

Supplementary data

Open the PDF for in another window

Topics: animals, transgenic , insulin , mice, inbred nod , peptides , t-lymphocytes

Diabetes February 2009, Vol.58, 1156-1164. doi:https://doi.org/10.2337/db08-0800

Islet Studies

Munc18c Depletion Selectively Impairs the Sustained Phase of Insulin Release

Eunjin Oh; Debbie C. Thurmond

Abstracts

View articletitled, Munc18c Depletion Selectively Impairs the Sustained Phase of Insulin Release

Open the PDF for in another window

Topics: glucose , granules , insulin , mice , cell membrane

Diabetes February 2009, Vol.58, 1165-1174. doi:https://doi.org/10.2337/db08-1059

Dynamic Changes in Pancreatic Endocrine Cell Abundance, Distribution, and Function in Antigen-Induced and Spontaneous Autoimmune Diabetes

Klaus Pechhold; Xiaolong Zhu; Victor S. Harrison; Janet Lee; Sagarika Chakrabarty; Kerstin Koczwara; Oksana Gavrilova; David M. Harlan

Abstracts

View articletitled, Dynamic Changes in Pancreatic Endocrine Cell Abundance, Distribution, and Function in Antigen-Induced and Spontaneous Autoimmune Diabetes

Supplementary data

Open the PDF for in another window

Topics: antigens , autoimmunity , endocrine cells , endocrine pancreas , flow cytometry

Diabetes February 2009, Vol.58, 1175-1184. doi:https://doi.org/10.2337/db08-0616

Pathophysiology

Muscle Microvascular Dysfunction in Central Obesity Is Related to Muscle Insulin Insensitivity but Is Not Reversed by High-Dose Statin Treatment

Geraldine F. Clough; Magdalena Turzyniecka; Lara Walter; Andrew J. Krentz; Sarah H. Wild; Andrew J. Chipperfield; John Gamble; Christopher D. Byrne

Abstracts

View articletitled, Muscle Microvascular Dysfunction in Central Obesity Is Related to Muscle Insulin Insensitivity but Is Not Reversed by High-Dose Statin Treatment

Supplementary data

Open the PDF for in another window

Topics: glucose , insulin , obesity , statins , insulin sensitivity

Diabetes February 2009, Vol.58, 1185-1191. doi:https://doi.org/10.2337/db08-1688

Accelerated Postnatal Growth Increases Lipogenic Gene Expression and Adipocyte Size in Low–Birth Weight Mice

Elvira Isganaitis; Jose Jimenez-Chillaron; Melissa Woo; Alice Chow; Jennifer DeCoste; Martha Vokes; Manway Liu; Simon Kasif; Ann-Marie Zavacki; Rebecca L. Leshan; Martin G. Myers; Mary-Elizabeth Patti

Abstracts

View articletitled, Accelerated Postnatal Growth Increases Lipogenic Gene Expression and Adipocyte Size in Low–Birth Weight Mice

Supplementary data

Open the PDF for in another window

Topics: adipocytes , gene expression , mice , genes , dna, mitochondrial

Diabetes February 2009, Vol.58, 1192-1200. doi:https://doi.org/10.2337/db08-1266

Mechanisms of Podocyte Injury in Diabetes: Role of Cytochrome P450 and NADPH Oxidases

Assaad A. Eid; Yves Gorin; Bridget M. Fagg; Rita Maalouf; Jeffrey L. Barnes; Karen Block; Hanna E. Abboud

Abstracts

View articletitled, Mechanisms of Podocyte Injury in Diabetes: Role of Cytochrome P450 and NADPH Oxidases

Open the PDF for in another window

Topics: 20-hydroxy-5,8,11,14-eicosatetraenoic acid , glucose , mice , nadph oxidases , podocytes

Diabetes February 2009, Vol.58, 1201-1211. doi:https://doi.org/10.2337/db08-1536

Changes in Insulin Sensitivity and Insulin Release in Relation to Glycemia and Glucose Tolerance in 6,414 Finnish Men

Alena Stančáková; Martin Javorský; Teemu Kuulasmaa; Steven M. Haffner; Johanna Kuusisto; Markku Laakso

Abstracts

View articletitled, Changes in Insulin Sensitivity and Insulin Release in Relation to Glycemia and Glucose Tolerance in 6,414 Finnish Men

Open the PDF for in another window

Topics: deuterium , insulin , insulin sensitivity , glucose , impaired fasting glucose

Diabetes February 2009, Vol.58, 1212-1221. doi:https://doi.org/10.2337/db08-1607

Complications

Specific Local Cardiovascular Changes of N^ɛ-(Carboxymethyl)lysine, Vascular Endothelial Growth Factor, and Smad2 in the Developing Embryos Coincide With Maternal Diabetes–Induced Congenital Heart Defects

Pauline A.M. Roest; Daniël G.M. Molin; Casper G. Schalkwijk; Liesbeth van Iperen; Parri Wentzel; Ulf J. Eriksson; Adriana C. Gittenberger-de Groot

Abstracts

View articletitled, Specific Local Cardiovascular Changes of Nɛ-(Carboxymethyl)lysine, Vascular Endothelial Growth Factor, and Smad2 in the Developing Embryos Coincide With Maternal Diabetes–Induced Congenital Heart Defects

Open the PDF for in another window

Topics: cardiovascular system , congenital heart defects , embryo , gestational diabetes , vascular endothelial growth factor a

Diabetes February 2009, Vol.58, 1222-1228. doi:https://doi.org/10.2337/db07-1016

Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail

Daniella Brasacchio; Jun Okabe; Christos Tikellis; Aneta Balcerczyk; Prince George; Emma K. Baker; Anna C. Calkin; Michael Brownlee; Mark E. Cooper; Assam El-Osta

Abstracts

View articletitled, Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail

Open the PDF for in another window

Topics: enzymes , genes , glucose , histone methyltransferases , hyperglycemia

Diabetes February 2009, Vol.58, 1229-1236. doi:https://doi.org/10.2337/db08-1666

Medium-Chain Fatty Acids Improve Cognitive Function in Intensively Treated Type 1 Diabetic Patients and Support In Vitro Synaptic Transmission During Acute Hypoglycemia

Kathleen A. Page; Anne Williamson; Namyi Yu; Ewan C. McNay; James Dzuira; Rory J. McCrimmon; Robert S. Sherwin

Abstracts

View articletitled, Medium-Chain Fatty Acids Improve Cognitive Function in Intensively Treated Type 1 Diabetic Patients and Support In Vitro Synaptic Transmission During Acute Hypoglycemia

Open the PDF for in another window

Topics: caprylates , cognitive ability , glucose , hydroxybutyrates , hypoglycemia

Diabetes February 2009, Vol.58, 1237-1244. doi:https://doi.org/10.2337/db08-1557

Genetics

Functional Targets of the Monogenic Diabetes Transcription Factors HNF-1α and HNF-4α Are Highly Conserved Between Mice and Humans

Sylvia F. Boj; Joan Marc Servitja; David Martin; Martin Rios; Iannis Talianidis; Roderic Guigo; Jorge Ferrer

Abstracts

View articletitled, Functional Targets of the Monogenic Diabetes Transcription Factors HNF-1α and HNF-4α Are Highly Conserved Between Mice and Humans

Supplementary data

Open the PDF for in another window

Topics: genes , mice , transcription factor , liver

Diabetes February 2009, Vol.58, 1245-1253. doi:https://doi.org/10.2337/db08-0812

Online Letter to the Editor

Comment on: Torii et al. (2009) Gene Silencing of Phogrin Unveils Its Essential Role in Glucose-Responsive Pancreatic β-Cell Growth. Diabetes 58:682–692

Yafang Hu; Takuya Nishimura; Aiping Zhang; Abner L. Notkins

Abstract

View articletitled, Comment on: Torii et al. (2009) Gene Silencing of Phogrin Unveils Its Essential Role in Glucose-Responsive Pancreatic β-Cell Growth. Diabetes 58:682–692

Open the PDF for in another window

Topics: gene silencing , glucose , pancreas

Diabetes May 2009, Vol.58, e8. doi:https://doi.org/10.2337/db09-0168

Issues

Commentary

Commentaries

Original Article

Metabolism

Signal Transduction

Obesity Studies

Immunology and Transplantation

Islet Studies

Pathophysiology

Complications

Genetics

Online Letter to the Editor

Email alerts

RSS Feeds

Journals

Books

Clinical Compendia

News

Other

About

Resources

This Feature Is Available To Subscribers Only