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GPR40: Good Cop, Bad Cop?
Diabetes May 2009, Vol.58, 1035-1036. doi:https://doi.org/10.2337/db09-0215
Adipose Tissue Plasticity in Catch-Up–Growth Trajectories to Metabolic Syndrome: Hyperplastic Versus Hypertrophic Catch-Up Fat
Diabetes May 2009, Vol.58, 1037-1039. doi:https://doi.org/10.2337/db09-0290
Original Article
Metabolism
Liver-Specific Loss of Lipolysis-Stimulated Lipoprotein Receptor Triggers Systemic Hyperlipidemia in Mice
Prachiti Narvekar; Mauricio Berriel Diaz; Anja Krones-Herzig; Ulrike Hardeland; Daniela Strzoda; Sigrid Stöhr; Marcus Frohme; Stephan Herzig
Diabetes February 2009, Vol.58, 1040-1049. doi:https://doi.org/10.2337/db08-1184
MicroRNAs Induced During Adipogenesis that Accelerate Fat Cell Development Are Downregulated in Obesity
Diabetes February 2009, Vol.58, 1050-1057. doi:https://doi.org/10.2337/db08-1299
GPR119 Is Essential for Oleoylethanolamide-Induced Glucagon-Like Peptide-1 Secretion From the Intestinal Enteroendocrine L-Cell
Diabetes February 2009, Vol.58, 1058-1066. doi:https://doi.org/10.2337/db08-1237
Overexpression of GPR40 in Pancreatic β-Cells Augments Glucose-Stimulated Insulin Secretion and Improves Glucose Tolerance in Normal and Diabetic Mice
Kae Nagasumi; Ritsuko Esaki; Kimihiko Iwachidow; Yoshitaka Yasuhara; Kazuhiro Ogi; Hideyuki Tanaka; Mitsugu Nakata; Takashi Yano; Kozo Shimakawa; Shigehisa Taketomi; Koji Takeuchi; Hiroyuki Odaka; Yoshihiko Kaisho
Diabetes February 2009, Vol.58, 1067-1076. doi:https://doi.org/10.2337/db08-1233
Signal Transduction
High Glucose Suppresses Epidermal Growth Factor Receptor/Phosphatidylinositol 3-Kinase/Akt Signaling Pathway and Attenuates Corneal Epithelial Wound Healing
Diabetes February 2009, Vol.58, 1077-1085. doi:https://doi.org/10.2337/db08-0997
Interleukin-6 Attenuates Insulin-Mediated Increases in Endothelial Cell Signaling but Augments Skeletal Muscle Insulin Action via Differential Effects on Tumor Necrosis Factor-α Expression
Derek Y.C. Yuen; Renee M. Dwyer; Vance B. Matthews; Lei Zhang; Brian G. Drew; Bronwyn Neill; Bronwyn A. Kingwell; Michael G. Clark; Stephen Rattigan; Mark A. Febbraio
Diabetes February 2009, Vol.58, 1086-1095. doi:https://doi.org/10.2337/db08-0775
Degradation of cAMP-Responsive Element–Binding Protein by the Ubiquitin-Proteasome Pathway Contributes to Glucotoxicity in β-Cells and Human Pancreatic Islets
Safia Costes; Brigitte Vandewalle; Cécile Tourrel-Cuzin; Christophe Broca; Nathalie Linck; Gyslaine Bertrand; Julie Kerr-Conte; Bernard Portha; François Pattou; Joel Bockaert; Stéphane Dalle
Diabetes February 2009, Vol.58, 1105-1115. doi:https://doi.org/10.2337/db08-0926
Obesity Studies
Prenatal Stress or High-Fat Diet Increases Susceptibility to Diet-Induced Obesity in Rat Offspring
Diabetes February 2009, Vol.58, 1116-1125. doi:https://doi.org/10.2337/db08-1129
Weight Loss May Reverse Blunted Sympathetic Neural Responsiveness to Glucose Ingestion in Obese Subjects With Metabolic Syndrome
Nora E. Straznicky; Gavin W. Lambert; Mariee T. McGrane; Kazuko Masuo; Tye Dawood; Paul J. Nestel; Nina Eikelis; Markus P. Schlaich; Murray D. Esler; Florentia Socratous; Reena Chopra; Elisabeth A. Lambert
Diabetes February 2009, Vol.58, 1126-1132. doi:https://doi.org/10.2337/db08-1595
Loss-of-Function Mutation in Myostatin Reduces Tumor Necrosis Factor α Production and Protects Liver Against Obesity-Induced Insulin Resistance
Diabetes February 2009, Vol.58, 1133-1143. doi:https://doi.org/10.2337/db08-0245
Immunology and Transplantation
Interleukin-21 Is Required for the Development of Type 1 Diabetes in NOD Mice
Andrew P.R. Sutherland; Tom Van Belle; Andrea L. Wurster; Akira Suto; Monia Michaud; Dorothy Zhang; Michael J. Grusby; Matthias von Herrath
Diabetes February 2009, Vol.58, 1144-1155. doi:https://doi.org/10.2337/db08-0882
Activation of Insulin-Reactive CD8 T-Cells for Development of Autoimmune Diabetes
Diabetes February 2009, Vol.58, 1156-1164. doi:https://doi.org/10.2337/db08-0800
Islet Studies
Munc18c Depletion Selectively Impairs the Sustained Phase of Insulin Release
Diabetes February 2009, Vol.58, 1165-1174. doi:https://doi.org/10.2337/db08-1059
Dynamic Changes in Pancreatic Endocrine Cell Abundance, Distribution, and Function in Antigen-Induced and Spontaneous Autoimmune Diabetes
Klaus Pechhold; Xiaolong Zhu; Victor S. Harrison; Janet Lee; Sagarika Chakrabarty; Kerstin Koczwara; Oksana Gavrilova; David M. Harlan
Diabetes February 2009, Vol.58, 1175-1184. doi:https://doi.org/10.2337/db08-0616
Pathophysiology
Muscle Microvascular Dysfunction in Central Obesity Is Related to Muscle Insulin Insensitivity but Is Not Reversed by High-Dose Statin Treatment
Geraldine F. Clough; Magdalena Turzyniecka; Lara Walter; Andrew J. Krentz; Sarah H. Wild; Andrew J. Chipperfield; John Gamble; Christopher D. Byrne
Diabetes February 2009, Vol.58, 1185-1191. doi:https://doi.org/10.2337/db08-1688
Accelerated Postnatal Growth Increases Lipogenic Gene Expression and Adipocyte Size in Low–Birth Weight Mice
Elvira Isganaitis; Jose Jimenez-Chillaron; Melissa Woo; Alice Chow; Jennifer DeCoste; Martha Vokes; Manway Liu; Simon Kasif; Ann-Marie Zavacki; Rebecca L. Leshan; Martin G. Myers; Mary-Elizabeth Patti
Diabetes February 2009, Vol.58, 1192-1200. doi:https://doi.org/10.2337/db08-1266
Mechanisms of Podocyte Injury in Diabetes: Role of Cytochrome P450 and NADPH Oxidases
Assaad A. Eid; Yves Gorin; Bridget M. Fagg; Rita Maalouf; Jeffrey L. Barnes; Karen Block; Hanna E. Abboud
Diabetes February 2009, Vol.58, 1201-1211. doi:https://doi.org/10.2337/db08-1536
Changes in Insulin Sensitivity and Insulin Release in Relation to Glycemia and Glucose Tolerance in 6,414 Finnish Men
Alena Stančáková; Martin Javorský; Teemu Kuulasmaa; Steven M. Haffner; Johanna Kuusisto; Markku Laakso
Diabetes February 2009, Vol.58, 1212-1221. doi:https://doi.org/10.2337/db08-1607
Complications
Specific Local Cardiovascular Changes of Nɛ-(Carboxymethyl)lysine, Vascular Endothelial Growth Factor, and Smad2 in the Developing Embryos Coincide With Maternal Diabetes–Induced Congenital Heart Defects
Pauline A.M. Roest; Daniël G.M. Molin; Casper G. Schalkwijk; Liesbeth van Iperen; Parri Wentzel; Ulf J. Eriksson; Adriana C. Gittenberger-de Groot
Diabetes February 2009, Vol.58, 1222-1228. doi:https://doi.org/10.2337/db07-1016
Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail
Daniella Brasacchio; Jun Okabe; Christos Tikellis; Aneta Balcerczyk; Prince George; Emma K. Baker; Anna C. Calkin; Michael Brownlee; Mark E. Cooper; Assam El-Osta
Diabetes February 2009, Vol.58, 1229-1236. doi:https://doi.org/10.2337/db08-1666
Medium-Chain Fatty Acids Improve Cognitive Function in Intensively Treated Type 1 Diabetic Patients and Support In Vitro Synaptic Transmission During Acute Hypoglycemia
Kathleen A. Page; Anne Williamson; Namyi Yu; Ewan C. McNay; James Dzuira; Rory J. McCrimmon; Robert S. Sherwin
Diabetes February 2009, Vol.58, 1237-1244. doi:https://doi.org/10.2337/db08-1557
Genetics
Functional Targets of the Monogenic Diabetes Transcription Factors HNF-1α and HNF-4α Are Highly Conserved Between Mice and Humans
Sylvia F. Boj; Joan Marc Servitja; David Martin; Martin Rios; Iannis Talianidis; Roderic Guigo; Jorge Ferrer
Diabetes February 2009, Vol.58, 1245-1253. doi:https://doi.org/10.2337/db08-0812
