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Commentaries
Linking the Genetics of Type 2 Diabetes With Low Birth Weight: A Role for Prenatal Islet Maldevelopment?
Topics:
diabetes mellitus, type 2
,
genetics
,
low birth weight infant
,
prenatal care
,
insulin
Diabetes June 2009, Vol.58, 1255-1256. doi:https://doi.org/10.2337/db09-0225
Insulitis in Type 1 Diabetes: A Sticky Problem
Topics:
diabetes mellitus, type 1
Diabetes June 2009, Vol.58, 1257-1258. doi:https://doi.org/10.2337/db09-0345
Original Article
Metabolism
c-Jun NH2-Terminal Kinase Activity in Subcutaneous Adipose Tissue but Not Nuclear Factor-κB Activity in Peripheral Blood Mononuclear Cells Is an Independent Determinant of Insulin Resistance in Healthy Individuals
Karly C. Sourris; Jasmine G. Lyons; Maximilian P.J. de Courten; Sonia L. Dougherty; Darren C. Henstridge; Mark E. Cooper; Michelle Hage; Anthony Dart; Bronwyn A. Kingwell; Josephine M. Forbes; Barbora de Courten
Topics:
adipose tissue
,
biopsy
,
fat, subcutaneous
,
inflammatory markers
,
insulin resistance
Diabetes March 2009, Vol.58, 1259-1265. doi:https://doi.org/10.2337/db08-1725
Recurrent Antecedent Hypoglycemia Alters Neuronal Oxidative Metabolism In Vivo
Lihong Jiang; Raimund I. Herzog; Graeme F. Mason; Robin A. de Graaf; Douglas L. Rothman; Robert S. Sherwin; Kevin L. Behar
Topics:
acetates
,
blood glucose normal
,
glucose
,
hypoglycemia
,
infusion procedures
Diabetes March 2009, Vol.58, 1266-1274. doi:https://doi.org/10.2337/db08-1664
FoxO1 Haploinsufficiency Protects Against High-Fat Diet–Induced Insulin Resistance With Enhanced Peroxisome Proliferator–Activated Receptor γ Activation in Adipose Tissue
Topics:
forkhead box protein o1
,
insulin
,
mice
,
insulin resistance
,
glucose
Diabetes March 2009, Vol.58, 1275-1282. doi:https://doi.org/10.2337/db08-1001
Signal Transduction
PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon-γ–Induced Pancreatic β-Cell Apoptosis
Fabrice Moore; Maikel L. Colli; Miriam Cnop; Mariana Igoillo Esteve; Alessandra K. Cardozo; Daniel A. Cunha; Marco Bugliani; Piero Marchetti; Décio L. Eizirik
Topics:
apoptosis
,
cytokine
,
diabetes mellitus, type 1
,
rna, messenger
,
stat1 gene
Diabetes March 2009, Vol.58, 1283-1291. doi:https://doi.org/10.2337/db08-1510
Immunology and Transplantation
Genetic Deficiency of Itgb2 or ItgaL Prevents Autoimmune Diabetes Through Distinctly Different Mechanisms in NOD/LtJ Mice
John D. Glawe; D. Ross Patrick; Meng Huang; Christopher D. Sharp; Shayne C. Barlow; Christopher G. Kevil
Topics:
cd18 antigens
,
mice
,
t-lymphocytes
,
genetics
,
autoimmunity
Diabetes February 2009, Vol.58, 1292-1301. doi:https://doi.org/10.2337/db08-0804
Inhibition of Th17 Cells Regulates Autoimmune Diabetes in NOD Mice
Juliet A. Emamaullee; Joy Davis; Shaheed Merani; Christian Toso; John F. Elliott; Aducio Thiesen; A.M. James Shapiro
Topics:
interleukin-17
,
interleukin-17e
,
th17 cells
,
autoimmunity
,
mice, inbred nod
Diabetes March 2009, Vol.58, 1302-1311. doi:https://doi.org/10.2337/db08-1113
Islet Studies
Age-Dependent Decline in β-Cell Proliferation Restricts the Capacity of β-Cell Regeneration in Mice
Topics:
exenatide
,
mice
,
genes, p16
,
pancreas
,
aging
Diabetes February 2009, Vol.58, 1312-1320. doi:https://doi.org/10.2337/db08-1651
Upregulation of the Mammalian Target of Rapamycin Complex 1 Pathway by Ras Homolog Enriched in Brain in Pancreatic β-Cells Leads to Increased β-Cell Mass and Prevention of Hyperglycemia
Suirin Hamada; Kenta Hara; Takeshi Hamada; Hisafumi Yasuda; Hiroaki Moriyama; Rika Nakayama; Masao Nagata; Koichi Yokono
Topics:
antibodies
,
hyperglycemia
,
insulin
,
mechanistic target of rapamycin complex 1
,
mice
Diabetes March 2009, Vol.58, 1321-1332. doi:https://doi.org/10.2337/db08-0519
Pathophysiology
Short-Term Exercise Training Does Not Stimulate Skeletal Muscle ATP Synthesis in Relatives of Humans With Type 2 Diabetes
Gertrud Kacerovsky-Bielesz; Marek Chmelik; Charlotte Ling; Rochus Pokan; Julia Szendroedi; Michaela Farukuoye; Michaela Kacerovsky; Albrecht I. Schmid; Stephan Gruber; Michael Wolzt; Ewald Moser; Giovanni Pacini; Gerhard Smekal; Leif Groop; Michael Roden
Topics:
diabetes mellitus, type 2
,
diet
,
insulin
,
insulin sensitivity
,
lipids
Diabetes March 2009, Vol.58, 1333-1341. doi:https://doi.org/10.2337/db08-1240
Exogenous Glucose–Dependent Insulinotropic Polypeptide Worsens Post prandial Hyperglycemia in T ype 2 Diabetes
Chee W. Chia; Olga D. Carlson; Wook Kim; Yu-Kyong Shin; Cornelia P. Charles; Hee Seung Kim; Denise L. Melvin; Josephine M. Egan
Topics:
diabetes mellitus, type 2
,
glucagon
,
glucagon-like peptide 1
,
glucose
,
hyperglycemia
Diabetes March 2009, Vol.58, 1342-1349. doi:https://doi.org/10.2337/db08-0958
Increased Risk of Type 2 Diabetes in Elderly Twins
Pernille Poulsen; Louise G. Grunnet; Kasper Pilgaard; Heidi Storgaard; Amra Alibegovic; Mette P. Sonne; Bendix Carstensen; Henning Beck-Nielsen; Allan Vaag
Topics:
diabetes mellitus, type 2
,
follow-up
,
twins
,
older adult
,
glucose
Diabetes March 2009, Vol.58, 1350-1355. doi:https://doi.org/10.2337/db08-1714
Complications
Development of Selective Axonopathy in Adult Sensory Neurons Isolated From Diabetic Rats: Role of Glucose-Induced Oxidative Stress
Topics:
axon
,
ganglia, spinal
,
glucose
,
neurons
,
neurons, afferent
Diabetes February 2009, Vol.58, 1356-1364. doi:https://doi.org/10.2337/db09-0034
Adaptive β-Cell Proliferation Is Severely Restricted With Advanced Age
Topics:
mice
,
pancreatectomy
,
bromodeoxyuridine
,
streptozocin
Diabetes March 2009, Vol.58, 1365-1372. doi:https://doi.org/10.2337/db08-1198
Gene Deletion of the Kinin Receptor B1 Attenuates Cardiac Inflammation and Fibrosis During the Development of Experimental Diabetic Cardiomyopathy
Dirk Westermann; Thomas Walther; Konstantinos Savvatis; Felcicitas Escher; Meike Sobirey; Alexander Riad; Michael Bader; Heinz-Peter Schultheiss; Carsten Tschöpe
Topics:
diabetic cardiomyopathy
,
fibrosis
,
inflammation
,
kinins
,
mice
Diabetes March 2009, Vol.58, 1373-1381. doi:https://doi.org/10.2337/db08-0329
Diabetic Retinal Neurodegeneration Is Associated With Mitochondrial Oxidative Stress and Is Improved by an Angiotensin Receptor Blocker in a Model Combining Hypertension and Diabetes
Kamila C. Silva; Mariana A.B. Rosales; Subrata K. Biswas; Jose B. Lopes de Faria; Jacqueline M. Lopes de Faria
Topics:
fluorescent antibody technique
,
glial fibrillary acidic protein
,
hypertension
,
hypertension and diabetes
,
losartan
Diabetes March 2009, Vol.58, 1382-1390. doi:https://doi.org/10.2337/db09-0166
Inactivation of GSK-3β by Metallothionein Prevents Diabetes-Related Changes in Cardiac Energy Metabolism, Inflammation, Nitrosative Damage, and Remodeling
Topics:
energy metabolism
,
fibrosis
,
glucose
,
heart
,
inflammation
Diabetes March 2009, Vol.58, 1391-1402. doi:https://doi.org/10.2337/db08-1697
Genetics
Genome-Wide Association Scan for Diabetic Nephropathy Susceptibility Genes in Type 1 Diabetes
Marcus G. Pezzolesi; G. David Poznik; Josyf C. Mychaleckyj; Andrew D. Paterson; Michelle T. Barati; Jon B. Klein; Daniel P.K. Ng; Grzegorz Placha; Luis H. Canani; Jacek Bochenski; Daryl Waggott; Michael L. Merchant; Bozena Krolewski; Lucia Mirea; Krzysztof Wanic; Pisut Katavetin; Masahiko Kure; Pawel Wolkow; Jonathon S. Dunn; Adam Smiles; William H. Walker; Andrew P. Boright; Shelley B. Bull; the DCCT/EDIC Research Group; Alessandro Doria; John J. Rogus; Stephen S. Rich; James H. Warram; Andrzej S. Krolewski
Topics:
diabetes mellitus, type 1
,
diabetic nephropathy
,
edic trial
,
genes
,
single nucleotide polymorphism
Diabetes February 2009, Vol.58, 1403-1410. doi:https://doi.org/10.2337/db08-1514
Previously Associated Type 2 Diabetes Variants May Interact With Physical Activity to Modify the Risk of Impaired Glucose Regulation and Type 2 Diabetes: A Study of 16,003 Swedish Adults
Ema C. Brito; Valeriya Lyssenko; Frida Renström; Göran Berglund; Peter M. Nilsson; Leif Groop; Paul W. Franks
Topics:
diabetes mellitus, type 2
,
genes
,
glucose
,
protein p16
,
deuterium
Diabetes March 2009, Vol.58, 1411-1418. doi:https://doi.org/10.2337/db08-1623
Extremes of Clinical and Enzymatic Phenotypes in Children With Hyperinsulinism Caused by Glucokinase Activating Mutations
Samir Sayed; David R. Langdon; Stella Odili; Pan Chen; Carol Buettger; Alisa B. Schiffman; Mariko Suchi; Rebecca Taub; Joseph Grimsby; Franz M. Matschinsky; Charles A. Stanley
Topics:
child
,
glucokinase
,
glucose
,
hyperinsulinism
,
mutation
Diabetes March 2009, Vol.58, 1419-1427. doi:https://doi.org/10.2337/db08-1792
Type 2 Diabetes Risk Alleles Are Associated With Reduced Size at Birth
Rachel M. Freathy; Amanda J. Bennett; Susan M. Ring; Beverley Shields; Christopher J. Groves; Nicholas J. Timpson; Michael N. Weedon; Eleftheria Zeggini; Cecilia M. Lindgren; Hana Lango; John R.B. Perry; Anneli Pouta; Aimo Ruokonen; Elina Hyppönen; Chris Power; Paul Elliott; David P. Strachan; Marjo-Riitta Järvelin; George Davey Smith; Mark I. McCarthy; Timothy M. Frayling; Andrew T. Hattersley
Topics:
birth weight
,
diabetes mellitus, type 2
,
fetus
,
genotype
,
alleles
Diabetes February 2009, Vol.58, 1428-1433. doi:https://doi.org/10.2337/db08-1739
Genetics
Reduced-Function SLC22A1 Polymorphisms Encoding Organic Cation Transporter 1 and Glycemic Response to Metformin: A GoDARTS Study
Kaixin Zhou; Louise A. Donnelly; Charlotte H. Kimber; Peter T. Donnan; Alex S.F. Doney; Graham Leese; Andrew T. Hattersley; Mark I. McCarthy; Andrew D. Morris; Colin N.A. Palmer; Ewan R. Pearson
Topics:
metformin
,
genotype
,
polymorphism
,
diabetes mellitus, type 2
Diabetes March 2009, Vol.58, 1434-1439. doi:https://doi.org/10.2337/db08-0896
Genetic Variant in the IGF2BP2 Gene May Interact With Fetal Malnutrition to Affect Glucose Metabolism
Topics:
diabetes mellitus, type 2
,
famine
,
fetal malnutrition
,
genes
,
genetics
Diabetes March 2009, Vol.58, 1440-1444. doi:https://doi.org/10.2337/db08-1173
Genetic Variation in KCNQ1 Associates With Fasting Glucose andβ-Cell Function: A Study of 3,734 Subjects Comprising Three Ethnicities Living in Singapore
Topics:
diabetes mellitus, type 2
,
fasting blood glucose measurement
,
kvlqt1
,
singapore
,
single nucleotide polymorphism
Diabetes February 2009, Vol.58, 1445-1449. doi:https://doi.org/10.2337/db08-1138
G-allele of Intronic rs10830963 in MTNR1B Confers Increased Risk of Impaired Fasting Glycemia and Type 2 Diabetes Through an Impaired Glucose-Stimulated Insulin Release: Studies Involving 19,605 Europeans
Thomas Sparsø; Amélie Bonnefond; Ehm Andersson; Nabila Bouatia-Naji; Johan Holmkvist; Lise Wegner; Niels Grarup; Anette P. Gjesing; Karina Banasik; Christine Cavalcanti-Proença; Marion Marchand; Martine Vaxillaire; Guillaume Charpentier; Marjo-Riitta Jarvelin; Jean Tichet; Beverley Balkau; Michel Marre; Claire Lévy-Marchal; Kristine Færch; Knut Borch-Johnsen; Torben Jørgensen; Sten Madsbad; Pernille Poulsen; Allan Vaag; Christian Dina; Torben Hansen; Oluf Pedersen; Philippe Froguel
Topics:
alleles
,
desir cohort
,
diabetes mellitus, type 2
,
glucose
,
impaired fasting glucose
Diabetes March 2009, Vol.58, 1450-1456. doi:https://doi.org/10.2337/db08-1660
Association of SSTR2 Polymorphisms and Glucose Homeostasis Phenotypes: The Insulin Resistance Atherosclerosis Family Study
Beth S. Sutton; Nicholette D. Palmer; Carl D. Langefeld; Bingzhong Xue; Alexandria Proctor; Julie T. Ziegler; Steven M. Haffner; Jill M. Norris; Donald W. Bowden
Topics:
atherosclerosis
,
family studies
,
glucose homeostasis
,
insulin resistance
,
phenotype
Diabetes March 2009, Vol.58, 1457-1462. doi:https://doi.org/10.2337/db08-0189
Interrogating Type 2 Diabetes Genome-Wide Association Data Using a Biological Pathway-Based Approach
John R.B. Perry; Mark I. McCarthy; Andrew T. Hattersley; Eleftheria Zeggini; the Wellcome Trust Case Control Consortium; Michael N. Weedon; Timothy M. Frayling
Topics:
diabetes mellitus, type 2
,
genes
,
genome
,
single nucleotide polymorphism
Diabetes February 2009, Vol.58, 1463-1467. doi:https://doi.org/10.2337/db08-1378
