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Volume 58, Issue 7
1 July 2009
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ISSN 0012-1797
EISSN 1939-327X
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Editorials

Mortality and Glycemic Targets in the Intensive Care Unit: Another Paradigm Shift?
William T. Cefalu
View articletitled, Mortality and Glycemic Targets in the Intensive Care Unit: Another Paradigm Shift?
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Diabetes July 2009, Vol.58, 1469-1470. doi:https://doi.org/10.2337/db09-0540

Original Article

Perspectives in Diabetes
Abnormal Angiogenesis in Diabetic Nephropathy
Takahiko Nakagawa; Tomoki Kosugi; Masakazu Haneda; Christopher J. Rivard; David A. Long
View articletitled, Abnormal Angiogenesis in Diabetic Nephropathy
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Diabetes July 2009, Vol.58, 1471-1478. doi:https://doi.org/10.2337/db09-0119
Metabolism
Modulation of Skeletal Muscle Insulin Signaling With Chronic Caloric Restriction in Cynomolgus Monkeys
Zhong Q. Wang; Z. Elizabeth Floyd; Jianhua Qin; Xiaotuan Liu; Yongmei Yu; Xian H. Zhang; Janice D. Wagner; William T. Cefalu
View articletitled, Modulation of Skeletal Muscle Insulin Signaling With Chronic Caloric Restriction in Cynomolgus Monkeys
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Diabetes March 2009, Vol.58, 1488-1498. doi:https://doi.org/10.2337/db08-0977
Sensitivity of Lipid Metabolism and Insulin Signaling to Genetic Alterations in Hepatic Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α Expression
Jennifer L. Estall; Mario Kahn; Marcus P. Cooper; ffolliott Martin Fisher; Michele K. Wu; Dina Laznik; Lishu Qu; David E. Cohen; Gerald I. Shulman; Bruce M. Spiegelman
View articletitled, Sensitivity of Lipid Metabolism and Insulin Signaling to Genetic Alterations in Hepatic Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α Expression
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Diabetes April 2009, Vol.58, 1499-1508. doi:https://doi.org/10.2337/db08-1571
Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice
Zhanguo Gao; Jun Yin; Jin Zhang; Robert E. Ward; Roy J. Martin; Michael Lefevre; William T. Cefalu; Jianping Ye
View articletitled, Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice
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Diabetes April 2009, Vol.58, 1509-1517. doi:https://doi.org/10.2337/db08-1637
Additive Interaction Between the Renin-Angiotensin System and Lipid Metabolism for Cancer in Type 2 Diabetes
Xilin Yang; Hailu Zhao; Yi Sui; Ronald C.W. Ma; Wing Yee So; Gary T.C. Ko; Alice P.S. Kong; Risa Ozaki; Chun Yip Yeung; Gang Xu; Peter C.Y. Tong; Juliana C.N. Chan
View articletitled, Additive Interaction Between the Renin-Angiotensin System and Lipid Metabolism for Cancer in Type 2 Diabetes
Supplementary data
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Diabetes April 2009, Vol.58, 1518-1525. doi:https://doi.org/10.2337/db09-0105
High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity
Masayuki Saito; Yuko Okamatsu-Ogura; Mami Matsushita; Kumiko Watanabe; Takeshi Yoneshiro; Junko Nio-Kobayashi; Toshihiko Iwanaga; Masao Miyagawa; Toshimitsu Kameya; Kunihiro Nakada; Yuko Kawai; Masayuki Tsujisaki
View articletitled, High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans<span class="subtitle-colon">: </span><span class="subtitle">Effects of Cold Exposure and Adiposity</span>
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Diabetes April 2009, Vol.58, 1526-1531. doi:https://doi.org/10.2337/db09-0530
Free Fatty Acids Link Metabolism and Regulation of the Insulin-Sensitizing Fibroblast Growth Factor-21
Knut Mai; Janin Andres; Katrin Biedasek; Jessica Weicht; Thomas Bobbert; Markus Sabath; Sabine Meinus; Franziska Reinecke; Matthias Möhlig; Martin O. Weickert; Markus Clemenz; Andreas F.H. Pfeiffer; Ulrich Kintscher; Simone Spuler; Joachim Spranger
View articletitled, Free Fatty Acids Link Metabolism and Regulation of the Insulin-Sensitizing Fibroblast Growth Factor-21
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Diabetes April 2009, Vol.58, 1532-1538. doi:https://doi.org/10.2337/db08-1775
Additional Evidence That Transaldolase Exchange, Isotope Discrimination During the Triose-Isomerase Reaction, or Both Occur in Humans: Effects of Type 2 Diabetes
Rita Basu; Visvanthan Chandramouli; William Schumann; Ananda Basu; Bernard R. Landau; Robert A. Rizza
View articletitled, Additional Evidence That Transaldolase Exchange, Isotope Discrimination During the Triose-Isomerase Reaction, or Both Occur in Humans<span class="subtitle-colon">: </span><span class="subtitle">Effects of Type 2 Diabetes</span>
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Diabetes April 2009, Vol.58, 1539-1543. doi:https://doi.org/10.2337/db08-1300
Signal Transduction
Hypothalamic Reactive Oxygen Species Are Required for Insulin-Induced Food Intake Inhibition: An NADPH Oxidase–Dependent Mechanism
Tristan Jaillard; Michael Roger; Anne Galinier; Pascale Guillou; Alexandre Benani; Corinne Leloup; Louis Casteilla; Luc Pénicaud; Anne Lorsignol
View articletitled, Hypothalamic Reactive Oxygen Species Are Required for Insulin-Induced Food Intake Inhibition<span class="subtitle-colon">: </span><span class="subtitle">An NADPH Oxidase–Dependent Mechanism</span>
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Diabetes April 2009, Vol.58, 1544-1549. doi:https://doi.org/10.2337/db08-1039
Obesity Studies
Impaired Preadipocyte Differentiation in Human Abdominal Obesity: Role of Wnt, Tumor Necrosis Factor-α, and Inflammation
Petter Isakson; Ann Hammarstedt; Birgit Gustafson; Ulf Smith
View articletitled, Impaired Preadipocyte Differentiation in Human Abdominal Obesity<span class="subtitle-colon">: </span><span class="subtitle">Role of Wnt, Tumor Necrosis Factor-α, and Inflammation</span>
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Diabetes April 2009, Vol.58, 1550-1557. doi:https://doi.org/10.2337/db08-1770
Macrophages and Adipocytes in Human Obesity: Adipose Tissue Gene Expression and Insulin Sensitivity During Calorie Restriction and Weight Stabilization
Frédéric Capel; Eva Klimčáková; Nathalie Viguerie; Balbine Roussel; Michaela Vítková; Michaela Kováčiková; Jan Polák; Zuzana Kováčová; Jean Galitzky; Jean-José Maoret; Jiří Hanáček; Tune H. Pers; Anne Bouloumié; Vladimir Štich; Dominique Langin
View articletitled, Macrophages and Adipocytes in Human Obesity<span class="subtitle-colon">: </span><span class="subtitle">Adipose Tissue Gene Expression and Insulin Sensitivity During Calorie Restriction and Weight Stabilization</span>
Supplementary data
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Diabetes April 2009, Vol.58, 1558-1567. doi:https://doi.org/10.2337/db09-0033
Immunology and Transplantation
CD4+CD25+ T-Cells Control Autoimmunity in the Absence of B-Cells
Eliana Mariño; Jeanette Villanueva; Stacey Walters; David Liuwantara; Fabienne Mackay; Shane T. Grey
View articletitled, CD4<sup>+</sup>CD25<sup>+</sup> T-Cells Control Autoimmunity in the Absence of B-Cells
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Diabetes March 2009, Vol.58, 1568-1577. doi:https://doi.org/10.2337/db08-1504
Majority of Children With Type 1 Diabetes Produce and Deposit Anti-Tissue Transglutaminase Antibodies in the Small Intestine
Mariantonia Maglio; Fiorella Florian; Monica Vecchiet; Renata Auricchio; Francesco Paparo; Raffaella Spadaro; Delia Zanzi; Luciano Rapacciuolo; Adriana Franzese; Daniele Sblattero; Roberto Marzari; Riccardo Troncone
View articletitled, Majority of Children With Type 1 Diabetes Produce and Deposit Anti-Tissue Transglutaminase Antibodies in the Small Intestine
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Diabetes April 2009, Vol.58, 1578-1584. doi:https://doi.org/10.2337/db08-0962
Pig Embryonic Pancreatic Tissue as a Source for Transplantation in Diabetes: Transient Treatment With Anti-LFA1, Anti-CD48, and FTY720 Enables Long-Term Graft Maintenance in Mice With Only Mild Ongoing Immunosuppression
Dalit Tchorsh-Yutsis; Gil Hecht; Anna Aronovich; Elias Shezen; Yael Klionsky; Chava Rosen; Rivka Bitcover; Smadar Eventov-Friedman; Helena Katchman; Sivan Cohen; Orna Tal; Oren Milstein; Hideo Yagita; Bruce R. Blazar; Yair Reisner
View articletitled, Pig Embryonic Pancreatic Tissue as a Source for Transplantation in Diabetes<span class="subtitle-colon">: </span><span class="subtitle">Transient Treatment With Anti-LFA1, Anti-CD48, and FTY720 Enables Long-Term Graft Maintenance in Mice With Only Mild Ongoing Immunosuppression</span>
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Diabetes April 2009, Vol.58, 1585-1594. doi:https://doi.org/10.2337/db09-0112
Islet Studies
Functional Assessment of Pancreatic β-Cell Area in Humans
Juris J. Meier; Bjoern A. Menge; Thomas G.K. Breuer; Christophe A. Müller; Andrea Tannapfel; Waldemar Uhl; Wolfgang E. Schmidt; Henning Schrader
View articletitled, Functional Assessment of Pancreatic β-Cell Area in Humans
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Diabetes July 2009, Vol.58, 1595-1603. doi:https://doi.org/10.2337/db08-1611
Beneficial Endocrine but Adverse Exocrine Effects of Sitagliptin in the Human Islet Amyloid Polypeptide Transgenic Rat Model of Type 2 Diabetes: Interactions With Metformin
Aleksey V. Matveyenko; Sarah Dry; Heather I. Cox; Artemis Moshtaghian; Tatyana Gurlo; Ryan Galasso; Alexandra E. Butler; Peter C. Butler
View articletitled, Beneficial Endocrine but Adverse Exocrine Effects of Sitagliptin in the Human Islet Amyloid Polypeptide Transgenic Rat Model of Type 2 Diabetes<span class="subtitle-colon">: </span><span class="subtitle">Interactions With Metformin</span>
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Diabetes April 2009, Vol.58, 1604-1615. doi:https://doi.org/10.2337/db09-0058
Inhibitory Effects of Leptin on Pancreatic α-Cell Function
Eva Tudurí; Laura Marroquí; Sergi Soriano; Ana B. Ropero; Thiago M. Batista; Sandra Piquer; Miguel A. López-Boado; Everardo M. Carneiro; Ramón Gomis; Angel Nadal; Ivan Quesada
View articletitled, Inhibitory Effects of Leptin on Pancreatic α-Cell Function
Supplementary data
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Diabetes April 2009, Vol.58, 1616-1624. doi:https://doi.org/10.2337/db08-1787
Complications
(Pro)renin Receptor–Mediated Signal Transduction and Tissue Renin-Angiotensin System Contribute to Diabetes-Induced Retinal Inflammation
Shingo Satofuka; Atsuhiro Ichihara; Norihiro Nagai; Kousuke Noda; Yoko Ozawa; Akiyoshi Fukamizu; Kazuo Tsubota; Hiroshi Itoh; Yuichi Oike; Susumu Ishida
View articletitled, (Pro)renin Receptor–Mediated Signal Transduction and Tissue Renin-Angiotensin System Contribute to Diabetes-Induced Retinal Inflammation
Supplementary data
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Diabetes April 2009, Vol.58, 1625-1633. doi:https://doi.org/10.2337/db08-0254
Elevated Triglycerides Correlate With Progression of Diabetic Neuropathy
Timothy D. Wiggin; Kelli A. Sullivan; Rodica Pop-Busui; Antonino Amato; Anders A.F. Sima; Eva L. Feldman
View articletitled, Elevated Triglycerides Correlate With Progression of Diabetic Neuropathy
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Diabetes May 2009, Vol.58, 1634-1640. doi:https://doi.org/10.2337/db08-1771
Allelic Depletion of grem1 Attenuates Diabetic Kidney Disease
Sarah A. Roxburgh; Jayesh J. Kattla; Simon P. Curran; Yvonne M. O'Meara; Carol A. Pollock; Roel Goldschmeding; Catherine Godson; Finian Martin; Derek P. Brazil
View articletitled, Allelic Depletion of <em>grem1</em> Attenuates Diabetic Kidney Disease
Supplementary data
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Diabetes April 2009, Vol.58, 1641-1650. doi:https://doi.org/10.2337/db08-1365
The Presence and Severity of Chronic Kidney Disease Predicts All-Cause Mortality in Type 1 Diabetes
Per-Henrik Groop; Merlin C. Thomas; John L. Moran; Johan Wadèn; Lena M. Thorn; Ville-Petteri Mäkinen; Milla Rosengård-Bärlund; Markku Saraheimo; Kustaa Hietala; Outi Heikkilä; Carol Forsblom; on behalf of the FinnDiane Study Group
View articletitled, The Presence and Severity of Chronic Kidney Disease Predicts All-Cause Mortality in Type 1 Diabetes
Supplementary data
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Diabetes April 2009, Vol.58, 1651-1658. doi:https://doi.org/10.2337/db08-1543
The Transforming Growth Factor-β Pathway Is a Common Target of Drugs That Prevent Experimental Diabetic Retinopathy
Chiara Gerhardinger; Zeina Dagher; Paola Sebastiani; Yong Seek Park; Mara Lorenzi
View articletitled, The Transforming Growth Factor-β Pathway Is a Common Target of Drugs That Prevent Experimental Diabetic Retinopathy
Supplementary data
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Diabetes April 2009, Vol.58, 1659-1667. doi:https://doi.org/10.2337/db08-1008
Serum Uric Acid as a Predictor for Development of Diabetic Nephropathy in Type 1 Diabetes: An Inception Cohort Study
Peter Hovind; Peter Rossing; Lise Tarnow; Richard J. Johnson; Hans-Henrik Parving
View articletitled, Serum Uric Acid as a Predictor for Development of Diabetic Nephropathy in Type 1 Diabetes<span class="subtitle-colon">: </span><span class="subtitle">An Inception Cohort Study</span>
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Diabetes May 2009, Vol.58, 1668-1671. doi:https://doi.org/10.2337/db09-0014
Genetics
Lack of Type VIII Collagen in Mice Ameliorates Diabetic Nephropathy
Ulrike Hopfer; Helmut Hopfer; Catherine Meyer-Schwesinger; Ivonne Loeffler; Naomi Fukai; Bjorn R. Olsen; Rolf A.K. Stahl; Gunter Wolf
View articletitled, Lack of Type VIII Collagen in Mice Ameliorates Diabetic Nephropathy
Supplementary data
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Diabetes April 2009, Vol.58, 1672-1681. doi:https://doi.org/10.2337/db08-0183
Common Variation in SIM1 Is Reproducibly Associated With BMI in Pi ma Indians
Michael Traurig; Janel Mack; Robert L. Hanson; Maya Ghoussaini; David Meyre; William C. Knowler; Sayuko Kobes; Philippe Froguel; Clifton Bogardus; Leslie J. Baier
View articletitled, Common Variation in <em>SIM1</em> Is Reproducibly Associated With BMI in Pi ma Indians
Supplementary data
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Diabetes April 2009, Vol.58, 1682-1689. doi:https://doi.org/10.2337/db09-0028
Confirmation of Multiple Risk Loci and Genetic Impacts by a Genome-Wide Association Study of Type 2 Diabetes in the Japanese Population
Fumihiko Takeuchi; Masakuni Serizawa; Ken Yamamoto; Tomomi Fujisawa; Eitaro Nakashima; Keizo Ohnaka; Hiroshi Ikegami; Takao Sugiyama; Tomohiro Katsuya; Makoto Miyagishi; Naoki Nakashima; Hajime Nawata; Jiro Nakamura; Suminori Kono; Ryoichi Takayanagi; Norihiro Kato
View articletitled, Confirmation of Multiple Risk Loci and Genetic Impacts by a Genome-Wide Association Study of Type 2 Diabetes in the Japanese Population
Supplementary data
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Diabetes April 2009, Vol.58, 1690-1699. doi:https://doi.org/10.2337/db08-1494
NOD × 129.H2g7 Backcross Delineates 129S1/SvImJ-Derived Genomic Regions Modulating Type 1 Diabetes Development in Mice
Edward H. Leiter; Peter C. Reifsnyder; Racheal Wallace; Renhua Li; Benjamin King; Gary C. Churchill
View articletitled, NOD × 129.<em>H2<sup>g7</sup></em> Backcross Delineates 129S1/SvImJ-Derived Genomic Regions Modulating Type 1 Diabetes Development in Mice
Supplementary data
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Diabetes March 2009, Vol.58, 1700-1703. doi:https://doi.org/10.2337/db09-0120
Linkage Disequilibrium Mapping of the Replicated Type 2 Diabetes Linkage Signal on Chromosome 1q
Inga Prokopenko; Eleftheria Zeggini; Robert L. Hanson; Braxton D. Mitchell; N. William Rayner; Pelin Akan; Leslie Baier; Swapan K. Das; Katherine S. Elliott; Mao Fu; Timothy M. Frayling; Christopher J. Groves; Rhian Gwilliam; Laura J. Scott; Benjamin F. Voight; Andrew T. Hattersley; Cheng Hu; Andrew D. Morris; Maggie Ng; Colin N.A. Palmer; Marcela Tello-Ruiz; Martine Vaxillaire; Cong-rong Wang; Lincoln Stein; Juliana Chan; Weiping Jia; Philippe Froguel; Steven C. Elbein; Panos Deloukas; Clifton Bogardus; Alan R. Shuldiner; Mark I. McCarthy; for the International Type 2 Diabetes 1q Consortium
View articletitled, Linkage Disequilibrium Mapping of the Replicated Type 2 Diabetes Linkage Signal on Chromosome 1q
Supplementary data
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Diabetes April 2009, Vol.58, 1704-1709. doi:https://doi.org/10.2337/db09-0081
Elevated MBL Concentrations Are Not an Indication of Association Between the MBL2 Gene and Type 1 Diabetes or Diabetic Nephropathy
Mari A. Kaunisto; Lisa Sjölind; Riitta Sallinen; Kim Pettersson-Fernholm; Markku Saraheimo; Sara Fröjdö; Carol Forsblom; Johan Fagerudd; Troels K. Hansen; Allan Flyvbjerg; Maija Wessman; Per-Henrik Groop; for the FinnDiane Study Group
View articletitled, Elevated MBL Concentrations Are Not an Indication of Association Between the <em>MBL2</em> Gene and Type 1 Diabetes or Diabetic Nephropathy
Supplementary data
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Diabetes April 2009, Vol.58, 1710-1714. doi:https://doi.org/10.2337/db08-1495
Association of Type 2 Diabetes Candidate Polymorphisms in KCNQ1 With Incretin and Insulin Secretion
Karsten Müssig; Harald Staiger; Fausto Machicao; Kerstin Kirchhoff; Martina Guthoff; Silke A. Schäfer; Konstantinos Kantartzis; Günther Silbernagel; Norbert Stefan; Jens J. Holst; Baptist Gallwitz; Hans-Ulrich Häring; Andreas Fritsche
View articletitled, Association of Type 2 Diabetes Candidate Polymorphisms in <em>KCNQ1</em> With Incretin and Insulin Secretion
Supplementary data
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Diabetes April 2009, Vol.58, 1715-1720. doi:https://doi.org/10.2337/db08-1589

Commentary

Commentaries
Targeting B-cells Mitigates Autoimmune Diabetes in NOD Mice: What Is Plan B?
Susan H. Smith; Thomas F. Tedder
View articletitled, Targeting B-cells Mitigates Autoimmune Diabetes in NOD Mice: What Is Plan B?
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Diabetes July 2009, Vol.58, 1479-1481. doi:https://doi.org/10.2337/db09-0497
Brown Fat in Humans: Turning up the Heat on Obesity
Patrick Seale; Mitchell A. Lazar
View articletitled, Brown Fat in Humans: Turning up the Heat on Obesity
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Diabetes July 2009, Vol.58, 1482-1484. doi:https://doi.org/10.2337/db09-0622
(Pro)renin Receptor: A Treatment Target for Diabetic Retinopathy?
Jennifer L. Wilkinson-Berka; Duncan J. Campbell
View articletitled, (Pro)renin Receptor: A Treatment Target for Diabetic Retinopathy?
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Diabetes July 2009, Vol.58, 1485-1487. doi:https://doi.org/10.2337/db09-0604

Erratum

Errata
View articletitled, Errata
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Diabetes July 2009, Vol.58, 1721. doi:https://doi.org/10.2337/db09-er07
Système International (SI) Units Table
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus
Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes: Many Differences, Few Similarities
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