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Volume 58, Issue 8
1 August 2009
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ISSN 0012-1797
EISSN 1939-327X
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Commentaries

Diet, Gut, and Type 1 Diabetes: Role of Wheat-Derived Peptides?
Mikael Knip
View articletitled, Diet, Gut, and Type 1 Diabetes: Role of Wheat-Derived Peptides?
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Diabetes August 2009, Vol.58, 1723-1724. doi:https://doi.org/10.2337/db09-0686
Bad News for β-Cell Apoptosis
Helen E. Thomas; Trevor J. Biden
View articletitled, Bad News for β-Cell Apoptosis
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Diabetes August 2009, Vol.58, 1725-1727. doi:https://doi.org/10.2337/db09-0732
Mesenchymal Stem Cells: A Potential Border Patrol for Transplanted Islets?
Todd M. Brusko
View articletitled, Mesenchymal Stem Cells: A Potential Border Patrol for Transplanted Islets?
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Diabetes August 2009, Vol.58, 1728-1729. doi:https://doi.org/10.2337/db09-0749
Primary Prevention of Type 2 Diabetes: There Are No Simple Solutions!
William T. Cefalu
View articletitled, Primary Prevention of Type 2 Diabetes: There Are No Simple Solutions!
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Diabetes August 2009, Vol.58, 1730-1731. doi:https://doi.org/10.2337/db09-0840

Original Article

New Methodologies and Databases
Diabetes Incidence Based on Linkages With Health Plans: The Multiethnic Cohort
Gertraud Maskarinec; Eva Erber; Andrew Grandinetti; Martijn Verheus; Robert Oum; Beth N. Hopping; Mark M. Schmidt; Aileen Uchida; Deborah Taira Juarez; Krista Hodges; Laurence N. Kolonel
View articletitled, Diabetes Incidence Based on Linkages With Health Plans: The Multiethnic Cohort
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Diabetes March 2009, Vol.58, 1732-1738. doi:https://doi.org/10.2337/db08-1685
Metabolism
Genetic Disruption of Myostatin Reduces the Development of Proatherogenic Dyslipidemia and Atherogenic Lesions In Ldlr Null Mice
Powen Tu; Shalender Bhasin; Paul W. Hruz; Karen L. Herbst; Lawrence W. Castellani; Ning Hua; James A. Hamilton; Wen Guo
View articletitled, Genetic Disruption of Myostatin Reduces the Development of Proatherogenic Dyslipidemia and Atherogenic Lesions In <em>Ldlr</em> Null Mice
Supplementary data
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Diabetes June 2009, Vol.58, 1739-1748. doi:https://doi.org/10.2337/db09-0349
A Functional Melanocortin System May Be Required for Chronic CNS-Mediated Antidiabetic and Cardiovascular Actions of Leptin
Alexandre A. da Silva; Jussara M. do Carmo; J. Nathan Freeman; Lakshmi S. Tallam; John E. Hall
View articletitled, A Functional Melanocortin System May Be Required for Chronic CNS-Mediated Antidiabetic and Cardiovascular Actions of Leptin
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Diabetes June 2009, Vol.58, 1749-1756. doi:https://doi.org/10.2337/db08-1221
Individual Stearoyl-CoA Desaturase 1 Expression Modulates Endoplasmic Reticulum Stress and Inflammation in Human Myotubes and Is Associated With Skeletal Muscle Lipid Storage and Insulin Sensitivity In Vivo
Andreas Peter; Cora Weigert; Harald Staiger; Fausto Machicao; Fritz Schick; Jürgen Machann; Norbert Stefan; Claus Thamer; Hans-Ulrich Häring; Erwin Schleicher
View articletitled, Individual Stearoyl-CoA Desaturase 1 Expression Modulates Endoplasmic Reticulum Stress and Inflammation in Human Myotubes and Is Associated With Skeletal Muscle Lipid Storage and Insulin Sensitivity In Vivo
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Diabetes May 2009, Vol.58, 1757-1765. doi:https://doi.org/10.2337/db09-0188
Insulin-Stimulated Cardiac Glucose Oxidation Is Increased in High-Fat Diet–Induced Obese Mice Lacking Malonyl CoA Decarboxylase
John R. Ussher; Timothy R. Koves; Jagdip S. Jaswal; Liyan Zhang; Olga Ilkayeva; Jason R.B. Dyck; Deborah M. Muoio; Gary D. Lopaschuk
View articletitled, Insulin-Stimulated Cardiac Glucose Oxidation Is Increased in High-Fat Diet–Induced Obese Mice Lacking Malonyl CoA Decarboxylase
Supplementary data
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Diabetes May 2009, Vol.58, 1766-1775. doi:https://doi.org/10.2337/db09-0011
Objectively Measured Sedentary Time May Predict Insulin Resistance Independent of Moderate- and Vigorous-Intensity Physical Activity
Hendrik J.F. Helmerhorst; Katrien Wijndaele; Søren Brage; Nicholas J. Wareham; Ulf Ekelund
View articletitled, Objectively Measured Sedentary Time May Predict Insulin Resistance Independent of Moderate- and Vigorous-Intensity Physical Activity
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Diabetes May 2009, Vol.58, 1776-1779. doi:https://doi.org/10.2337/db08-1773
Obesity Studies
Regulation of the Fibrosis and Angiogenesis Promoter SPARC/Osteonectin in Human Adipose Tissue by Weight Change, Leptin, Insulin, and Glucose
Katrina Kos; Steve Wong; Bee Tan; Anders Gummesson; Margareta Jernas; Niclas Franck; David Kerrigan; Fredrik H. Nystrom; Lena M.S. Carlsson; Harpal S. Randeva; Jonathan H. Pinkney; John P.H. Wilding
View articletitled, Regulation of the Fibrosis and Angiogenesis Promoter SPARC/Osteonectin in Human Adipose Tissue by Weight Change, Leptin, Insulin, and Glucose
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Diabetes June 2009, Vol.58, 1780-1788. doi:https://doi.org/10.2337/db09-0211
Immunology and Transplantation
Diabetes-Specific HLA-DR–Restricted Proinflammatory T-Cell Response to Wheat Polypeptides in Tissue Transglutaminase Antibody–Negative Patients With Type 1 Diabetes
Majid Mojibian; Habiba Chakir; David E. Lefebvre; Jennifer A. Crookshank; Brigitte Sonier; Erin Keely; Fraser W. Scott
View articletitled, Diabetes-Specific HLA-DR–Restricted Proinflammatory T-Cell Response to Wheat Polypeptides in Tissue Transglutaminase Antibody–Negative Patients With Type 1 Diabetes
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Diabetes April 2009, Vol.58, 1789-1796. doi:https://doi.org/10.2337/db08-1579
Mesenchymal Stem Cells Prevent the Rejection of Fully Allogenic Islet Grafts by the Immunosuppressive Activity of Matrix Metalloproteinase-2 and -9
Yunchuan Ding; Danmei Xu; Gang Feng; Andrew Bushell; Ruth J. Muschel; Kathryn J. Wood
View articletitled, Mesenchymal Stem Cells Prevent the Rejection of Fully Allogenic Islet Grafts by the Immunosuppressive Activity of Matrix Metalloproteinase-2 and -9
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Diabetes June 2009, Vol.58, 1797-1806. doi:https://doi.org/10.2337/db09-0317
Islet Studies
Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in β-Cells
Lars G. Grunnet; Reid Aikin; Morten F. Tonnesen; Steven Paraskevas; Lykke Blaabjerg; Joachim Størling; Lawrence Rosenberg; Nils Billestrup; Dusica Maysinger; Thomas Mandrup-Poulsen
View articletitled, Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in β-Cells
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Diabetes May 2009, Vol.58, 1807-1815. doi:https://doi.org/10.2337/db08-0178
Glucagon-Like Peptide-1 Protects β-Cells Against Apoptosis by Increasing the Activity of an Igf-2/Igf-1 Receptor Autocrine Loop
Marion Cornu; Jiang-Yan Yang; Evrim Jaccard; Carine Poussin; Christian Widmann; Bernard Thorens
View articletitled, Glucagon-Like Peptide-1 Protects β-Cells Against Apoptosis by Increasing the Activity of an Igf-2/Igf-1 Receptor Autocrine Loop
Supplementary data
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Diabetes April 2009, Vol.58, 1816-1825. doi:https://doi.org/10.2337/db09-0063
Deletion of PKCε Selectively Enhances the Amplifying Pathways of Glucose-Stimulated Insulin Secretion via Increased Lipolysis in Mouse β-Cells
James Cantley; James G. Burchfield; Gemma L. Pearson; Carsten Schmitz-Peiffer; Michael Leitges; Trevor J. Biden
View articletitled, Deletion of PKCε Selectively Enhances the Amplifying Pathways of Glucose-Stimulated Insulin Secretion via Increased Lipolysis in Mouse β-Cells
Supplementary data
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Diabetes April 2009, Vol.58, 1826-1834. doi:https://doi.org/10.2337/db09-0132
Enhanced Glucose Tolerance by SK4 Channel Inhibition in Pancreatic β-Cells
Martina Düfer; Belinda Gier; Daniela Wolpers; Peter Krippeit-Drews; Peter Ruth; Gisela Drews
View articletitled, Enhanced Glucose Tolerance by SK4 Channel Inhibition in Pancreatic β-Cells
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Diabetes April 2009, Vol.58, 1835-1843. doi:https://doi.org/10.2337/db08-1324
Regeneration of the Pancreas in Adult Zebrafish
Jennifer B. Moss; Punita Koustubhan; Melanie Greenman; Michael J. Parsons; Ingrid Walter; Larry G. Moss
View articletitled, Regeneration of the Pancreas in Adult Zebrafish
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Diabetes June 2009, Vol.58, 1844-1851. doi:https://doi.org/10.2337/db08-0628
The Retinoblastoma Protein and Its Homolog p130 Regulate the G1/S Transition in Pancreatic β-Cells
George Harb; Rupangi C. Vasavada; David Cobrinik; Andrew F. Stewart
View articletitled, The Retinoblastoma Protein and Its Homolog p130 Regulate the G<sub>1</sub>/S Transition in Pancreatic β-Cells
Supplementary data
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Diabetes June 2009, Vol.58, 1852-1862. doi:https://doi.org/10.2337/db08-0759
Chronology of Islet Differentiation Revealed By Temporal Cell Labeling
Takeshi Miyatsuka; Zhongmei Li; Michael S. German
View articletitled, Chronology of Islet Differentiation Revealed By Temporal Cell Labeling
Supplementary data
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Diabetes May 2009, Vol.58, 1863-1868. doi:https://doi.org/10.2337/db09-0390
Pathophysiology
Kir6.2 Variant E23K Increases ATP-Sensitive K+ Channel Activity and Is Associated With Impaired Insulin Release and Enhanced Insulin Sensitivity in Adults With Normal Glucose Tolerance
Dennis T. Villareal; Joseph C. Koster; Heather Robertson; Alejandro Akrouh; Kazuaki Miyake; Graeme I. Bell; Bruce W. Patterson; Colin G. Nichols; Kenneth S. Polonsky
View articletitled, Kir6.2 Variant E23K Increases ATP-Sensitive K<sup>+</sup> Channel Activity and Is Associated With Impaired Insulin Release and Enhanced Insulin Sensitivity in Adults With Normal Glucose Tolerance
Supplementary data
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Diabetes June 2009, Vol.58, 1869-1878. doi:https://doi.org/10.2337/db09-0025
Endoplasmic Reticulum Stress Regulates Adipocyte Resistin Expression
Martina I. Lefterova; Shannon E. Mullican; Takuya Tomaru; Mohammed Qatanani; Michael Schupp; Mitchell A. Lazar
View articletitled, Endoplasmic Reticulum Stress Regulates Adipocyte Resistin Expression
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Diabetes June 2009, Vol.58, 1879-1886. doi:https://doi.org/10.2337/db08-1706
Apolipoprotein B but not LDL Cholesterol Is Associated With Coronary Artery Calcification in Type 2 Diabetic Whites
Seth S. Martin; Atif N. Qasim; Nehal N. Mehta; Megan Wolfe; Karen Terembula; Stanley Schwartz; Nayyar Iqbal; Mark Schutta; Roshanak Bagheri; Muredach P. Reilly
View articletitled, Apolipoprotein B but not LDL Cholesterol Is Associated With Coronary Artery Calcification in Type 2 Diabetic Whites
Supplementary data
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Diabetes June 2009, Vol.58, 1887-1892. doi:https://doi.org/10.2337/db08-1794
Complications
In Vivo Activation of AMP-Activated Protein Kinase Attenuates Diabetes-Enhanced Degradation of GTP Cyclohydrolase I
Shuangxi Wang; Jian Xu; Ping Song; Benoit Viollet; Ming-Hui Zou
View articletitled, In Vivo Activation of AMP-Activated Protein Kinase Attenuates Diabetes-Enhanced Degradation of GTP Cyclohydrolase I
Supplementary data
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Diabetes June 2009, Vol.58, 1893-1901. doi:https://doi.org/10.2337/db09-0267
Nanoparticle-Mediated Expression of an Angiogenic Inhibitor Ameliorates Ischemia-Induced Retinal Neovascularization and Diabetes-Induced Retinal Vascular Leakage
Kyoungmin Park; Ying Chen; Yang Hu; Aaron S. Mayo; Uday B. Kompella; Richard Longeras; Jian-xing Ma
View articletitled, Nanoparticle-Mediated Expression of an Angiogenic Inhibitor Ameliorates Ischemia-Induced Retinal Neovascularization and Diabetes-Induced Retinal Vascular Leakage
Supplementary data
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Diabetes June 2009, Vol.58, 1902-1913. doi:https://doi.org/10.2337/db08-1327
Adult Stature and Diabetes Complications in Patients With Type 1 Diabetes: The FinnDiane Study and the Diabetes Control and Complications Trial
Johan Wadén; Carol Forsblom; Lena M. Thorn; Markku Saraheimo; Milla Rosengård-Bärlund; Outi Heikkilä; Kustaa Hietala; Ken Ong; Nicholas Wareham; Per-Henrik Groop; on behalf of the FinnDiane Study Group
View articletitled, Adult Stature and Diabetes Complications in Patients With Type 1 Diabetes<span class="subtitle-colon">: </span><span class="subtitle">The FinnDiane Study and the Diabetes Control and Complications Trial</span>
Supplementary data
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Diabetes June 2009, Vol.58, 1914-1920. doi:https://doi.org/10.2337/db08-1767
Pharmacology & Therapeutics
Effect of Homocysteine-Lowering Treatment With Folic Acid and B Vitamins on Risk of Type 2 Diabetes in Women: A Randomized, Controlled Trial
Yiqing Song; Nancy R. Cook; Christine M. Albert; Martin Van Denburgh; JoAnn E. Manson
View articletitled, Effect of Homocysteine-Lowering Treatment With Folic Acid and B Vitamins on Risk of Type 2 Diabetes in Women<span class="subtitle-colon">: </span><span class="subtitle">A Randomized, Controlled Trial</span>
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Diabetes June 2009, Vol.58, 1921-1928. doi:https://doi.org/10.2337/db09-0087
Genetics
Identification of a Novel β-Cell Glucokinase (GCK) Promoter Mutation (−71G>C) That Modulates GCK Gene Expression Through Loss of Allele-Specific Sp1 Binding Causing Mild Fasting Hyperglycemia in Humans
Daniela Gašperíková; Nicolas D. Tribble; Juraj Staník; Miroslava Hučková; Nadežda Mišovicová; Martijn van de Bunt; Lucia Valentínová; Beryl A. Barrow; L'ubomir Barák; Radoslav Dobránsky; Eva Bereczková; Jozef Michálek; Kate Wicks; Kevin Colclough; Julian C. Knight; Sian Ellard; Iwar Klimeš; Anna L. Gloyn
View articletitled, Identification of a Novel β-Cell Glucokinase (<em>GCK</em>) Promoter Mutation (−71G&gt;C) That Modulates <em>GCK</em> Gene Expression Through Loss of Allele-Specific Sp1 Binding Causing Mild Fasting Hyperglycemia in Humans
Supplementary data
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Diabetes May 2009, Vol.58, 1929-1935. doi:https://doi.org/10.2337/db09-0070

Erratum

Errata
View articletitled, Errata
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Diabetes August 2009, Vol.58, 1936. doi:https://doi.org/10.2337/db09-er08
Errata
View articletitled, Errata
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Diabetes August 2009, Vol.58, 1937. doi:https://doi.org/10.2337/db09-er08b
Système International (SI) Units Table
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus
Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes: Many Differences, Few Similarities
  • Online ISSN 1939-327X
  • Print ISSN 0012-1797

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