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Commentaries

Diet, Gut, and Type 1 Diabetes: Role of Wheat-Derived Peptides?

Mikael Knip

Abstracts

View articletitled, Diet, Gut, and Type 1 Diabetes: Role of Wheat-Derived Peptides?

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Topics: diabetes mellitus, type 1 , diet , peptides , wheat , intestines

Diabetes August 2009, Vol.58, 1723-1724. doi:https://doi.org/10.2337/db09-0686

Bad News for β-Cell Apoptosis

Helen E. Thomas; Trevor J. Biden

Abstracts

View articletitled, Bad News for β-Cell Apoptosis

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Topics: apoptosis , cytokine

Diabetes August 2009, Vol.58, 1725-1727. doi:https://doi.org/10.2337/db09-0732

Mesenchymal Stem Cells: A Potential Border Patrol for Transplanted Islets?

Todd M. Brusko

Abstracts

View articletitled, Mesenchymal Stem Cells: A Potential Border Patrol for Transplanted Islets?

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Topics: diabetes mellitus, type 1 , immunosuppressive agents , mesenchymal stem cells , t-lymphocytes , antigens, cd25

Diabetes August 2009, Vol.58, 1728-1729. doi:https://doi.org/10.2337/db09-0749

Primary Prevention of Type 2 Diabetes: There Are No Simple Solutions!

William T. Cefalu

Abstracts

View articletitled, Primary Prevention of Type 2 Diabetes: There Are No Simple Solutions!

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Topics: diabetes mellitus, type 2 , primary prevention , wafacs trial

Diabetes August 2009, Vol.58, 1730-1731. doi:https://doi.org/10.2337/db09-0840

Original Article

New Methodologies and Databases

Diabetes Incidence Based on Linkages With Health Plans: The Multiethnic Cohort

Gertraud Maskarinec; Eva Erber; Andrew Grandinetti; Martijn Verheus; Robert Oum; Beth N. Hopping; Mark M. Schmidt; Aileen Uchida; Deborah Taira Juarez; Krista Hodges; Laurence N. Kolonel

Abstracts

View articletitled, Diabetes Incidence Based on Linkages With Health Plans: The Multiethnic Cohort

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Topics: follow-up , body mass index procedure , hawaii

Diabetes March 2009, Vol.58, 1732-1738. doi:https://doi.org/10.2337/db08-1685

Metabolism

Genetic Disruption of Myostatin Reduces the Development of Proatherogenic Dyslipidemia and Atherogenic Lesions In Ldlr Null Mice

Powen Tu; Shalender Bhasin; Paul W. Hruz; Karen L. Herbst; Lawrence W. Castellani; Ning Hua; James A. Hamilton; Wen Guo

Abstracts

View articletitled, Genetic Disruption of Myostatin Reduces the Development of Proatherogenic Dyslipidemia and Atherogenic Lesions In Ldlr Null Mice

Supplementary data

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Topics: low density lipoprotein receptor , mice , insulin , glucose , lipoproteins, vldl

Diabetes June 2009, Vol.58, 1739-1748. doi:https://doi.org/10.2337/db09-0349

A Functional Melanocortin System May Be Required for Chronic CNS-Mediated Antidiabetic and Cardiovascular Actions of Leptin

Alexandre A. da Silva; Jussara M. do Carmo; J. Nathan Freeman; Lakshmi S. Tallam; John E. Hall

Abstracts

View articletitled, A Functional Melanocortin System May Be Required for Chronic CNS-Mediated Antidiabetic and Cardiovascular Actions of Leptin

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Topics: blood glucose , infusion procedures , leptin , rats , streptozocin

Diabetes June 2009, Vol.58, 1749-1756. doi:https://doi.org/10.2337/db08-1221

Individual Stearoyl-CoA Desaturase 1 Expression Modulates Endoplasmic Reticulum Stress and Inflammation in Human Myotubes and Is Associated With Skeletal Muscle Lipid Storage and Insulin Sensitivity In Vivo

Andreas Peter; Cora Weigert; Harald Staiger; Fausto Machicao; Fritz Schick; Jürgen Machann; Norbert Stefan; Claus Thamer; Hans-Ulrich Häring; Erwin Schleicher

Abstracts

View articletitled, Individual Stearoyl-CoA Desaturase 1 Expression Modulates Endoplasmic Reticulum Stress and Inflammation in Human Myotubes and Is Associated With Skeletal Muscle Lipid Storage and Insulin Sensitivity In Vivo

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Topics: cell culture techniques , inflammation , insulin sensitivity , palmitates , rna, messenger

Diabetes May 2009, Vol.58, 1757-1765. doi:https://doi.org/10.2337/db09-0188

Insulin-Stimulated Cardiac Glucose Oxidation Is Increased in High-Fat Diet–Induced Obese Mice Lacking Malonyl CoA Decarboxylase

John R. Ussher; Timothy R. Koves; Jagdip S. Jaswal; Liyan Zhang; Olga Ilkayeva; Jason R.B. Dyck; Deborah M. Muoio; Gary D. Lopaschuk

Abstracts

View articletitled, Insulin-Stimulated Cardiac Glucose Oxidation Is Increased in High-Fat Diet–Induced Obese Mice Lacking Malonyl CoA Decarboxylase

Supplementary data

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Topics: fasting , fatty acids , glucose , heart , insulin

Diabetes May 2009, Vol.58, 1766-1775. doi:https://doi.org/10.2337/db09-0011

Objectively Measured Sedentary Time May Predict Insulin Resistance Independent of Moderate- and Vigorous-Intensity Physical Activity

Hendrik J.F. Helmerhorst; Katrien Wijndaele; Søren Brage; Nicholas J. Wareham; Ulf Ekelund

Abstracts

View articletitled, Objectively Measured Sedentary Time May Predict Insulin Resistance Independent of Moderate- and Vigorous-Intensity Physical Activity

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Topics: fasting , follow-up , insulin , insulin resistance , lack of exercise

Diabetes May 2009, Vol.58, 1776-1779. doi:https://doi.org/10.2337/db08-1773

Obesity Studies

Regulation of the Fibrosis and Angiogenesis Promoter SPARC/Osteonectin in Human Adipose Tissue by Weight Change, Leptin, Insulin, and Glucose

Katrina Kos; Steve Wong; Bee Tan; Anders Gummesson; Margareta Jernas; Niclas Franck; David Kerrigan; Fredrik H. Nystrom; Lena M.S. Carlsson; Harpal S. Randeva; Jonathan H. Pinkney; John P.H. Wilding

Abstracts

View articletitled, Regulation of the Fibrosis and Angiogenesis Promoter SPARC/Osteonectin in Human Adipose Tissue by Weight Change, Leptin, Insulin, and Glucose

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Topics: adipose tissue , sparc study , leptin , insulin , glucose

Diabetes June 2009, Vol.58, 1780-1788. doi:https://doi.org/10.2337/db09-0211

Immunology and Transplantation

Diabetes-Specific HLA-DR–Restricted Proinflammatory T-Cell Response to Wheat Polypeptides in Tissue Transglutaminase Antibody–Negative Patients With Type 1 Diabetes

Majid Mojibian; Habiba Chakir; David E. Lefebvre; Jennifer A. Crookshank; Brigitte Sonier; Erin Keely; Fraser W. Scott

Abstracts

View articletitled, Diabetes-Specific HLA-DR–Restricted Proinflammatory T-Cell Response to Wheat Polypeptides in Tissue Transglutaminase Antibody–Negative Patients With Type 1 Diabetes

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Topics: antibodies , antigens , cytokine , diabetes mellitus, type 1 , hla-dr antigens

Diabetes April 2009, Vol.58, 1789-1796. doi:https://doi.org/10.2337/db08-1579

Mesenchymal Stem Cells Prevent the Rejection of Fully Allogenic Islet Grafts by the Immunosuppressive Activity of Matrix Metalloproteinase-2 and -9

Yunchuan Ding; Danmei Xu; Gang Feng; Andrew Bushell; Ruth J. Muschel; Kathryn J. Wood

Abstracts

View articletitled, Mesenchymal Stem Cells Prevent the Rejection of Fully Allogenic Islet Grafts by the Immunosuppressive Activity of Matrix Metalloproteinase-2 and -9

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Topics: antigens, cd25 , gelatinase a , gelatinase b , t-lymphocytes , interleukin-2

Diabetes June 2009, Vol.58, 1797-1806. doi:https://doi.org/10.2337/db09-0317

Islet Studies

Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in β-Cells

Lars G. Grunnet; Reid Aikin; Morten F. Tonnesen; Steven Paraskevas; Lykke Blaabjerg; Joachim Størling; Lawrence Rosenberg; Nils Billestrup; Dusica Maysinger; Thomas Mandrup-Poulsen

Abstracts

View articletitled, Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in β-Cells

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Topics: cytokine

Diabetes May 2009, Vol.58, 1807-1815. doi:https://doi.org/10.2337/db08-0178

Glucagon-Like Peptide-1 Protects β-Cells Against Apoptosis by Increasing the Activity of an Igf-2/Igf-1 Receptor Autocrine Loop

Marion Cornu; Jiang-Yan Yang; Evrim Jaccard; Carine Poussin; Christian Widmann; Bernard Thorens

Abstracts

View articletitled, Glucagon-Like Peptide-1 Protects β-Cells Against Apoptosis by Increasing the Activity of an Igf-2/Igf-1 Receptor Autocrine Loop

Supplementary data

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Topics: apoptosis , glucagon-like peptide 1 , insulin-like growth factor ii , insulin-like-growth factor i receptor , autocrine

Diabetes April 2009, Vol.58, 1816-1825. doi:https://doi.org/10.2337/db09-0063

Deletion of PKCε Selectively Enhances the Amplifying Pathways of Glucose-Stimulated Insulin Secretion via Increased Lipolysis in Mouse β-Cells

James Cantley; James G. Burchfield; Gemma L. Pearson; Carsten Schmitz-Peiffer; Michael Leitges; Trevor J. Biden

Abstracts

View articletitled, Deletion of PKCε Selectively Enhances the Amplifying Pathways of Glucose-Stimulated Insulin Secretion via Increased Lipolysis in Mouse β-Cells

Supplementary data

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Topics: glucose , insulin secretion , lipase , lipids , mice

Diabetes April 2009, Vol.58, 1826-1834. doi:https://doi.org/10.2337/db09-0132

Enhanced Glucose Tolerance by SK4 Channel Inhibition in Pancreatic β-Cells

Martina Düfer; Belinda Gier; Daniela Wolpers; Peter Krippeit-Drews; Peter Ruth; Gisela Drews

Abstracts

View articletitled, Enhanced Glucose Tolerance by SK4 Channel Inhibition in Pancreatic β-Cells

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Topics: glucose , glucose tolerance , pancreas , insulin , mice

Diabetes April 2009, Vol.58, 1835-1843. doi:https://doi.org/10.2337/db08-1324

Regeneration of the Pancreas in Adult Zebrafish

Jennifer B. Moss; Punita Koustubhan; Melanie Greenman; Michael J. Parsons; Ingrid Walter; Larry G. Moss

Abstracts

View articletitled, Regeneration of the Pancreas in Adult Zebrafish

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Topics: pancreas , streptozocin , zebrafish , insulin , blood glucose

Diabetes June 2009, Vol.58, 1844-1851. doi:https://doi.org/10.2337/db08-0628

The Retinoblastoma Protein and Its Homolog p130 Regulate the G₁/S Transition in Pancreatic β-Cells

George Harb; Rupangi C. Vasavada; David Cobrinik; Andrew F. Stewart

Abstracts

View articletitled, The Retinoblastoma Protein and Its Homolog p130 Regulate the G1/S Transition in Pancreatic β-Cells

Supplementary data

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Topics: mice , rbl2 gene , retinoblastoma protein , pancreas , insulin

Diabetes June 2009, Vol.58, 1852-1862. doi:https://doi.org/10.2337/db08-0759

Chronology of Islet Differentiation Revealed By Temporal Cell Labeling

Takeshi Miyatsuka; Zhongmei Li; Michael S. German

Abstracts

View articletitled, Chronology of Islet Differentiation Revealed By Temporal Cell Labeling

Supplementary data

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Topics: flow cytometry , pancreas , timer device , genes , fluorescence

Diabetes May 2009, Vol.58, 1863-1868. doi:https://doi.org/10.2337/db09-0390

Pathophysiology

Kir6.2 Variant E23K Increases ATP-Sensitive K⁺ Channel Activity and Is Associated With Impaired Insulin Release and Enhanced Insulin Sensitivity in Adults With Normal Glucose Tolerance

Dennis T. Villareal; Joseph C. Koster; Heather Robertson; Alejandro Akrouh; Kazuaki Miyake; Graeme I. Bell; Bruce W. Patterson; Colin G. Nichols; Kenneth S. Polonsky

Abstracts

View articletitled, Kir6.2 Variant E23K Increases ATP-Sensitive K+ Channel Activity and Is Associated With Impaired Insulin Release and Enhanced Insulin Sensitivity in Adults With Normal Glucose Tolerance

Supplementary data

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Topics: glucose , insulin , insulin secretion , insulin sensitivity , oral glucose tolerance test

Diabetes June 2009, Vol.58, 1869-1878. doi:https://doi.org/10.2337/db09-0025

Endoplasmic Reticulum Stress Regulates Adipocyte Resistin Expression

Martina I. Lefterova; Shannon E. Mullican; Takuya Tomaru; Mohammed Qatanani; Michael Schupp; Mitchell A. Lazar

Abstracts

View articletitled, Endoplasmic Reticulum Stress Regulates Adipocyte Resistin Expression

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Topics: resistin , rna, messenger , stress , adipocytes , emergency service, hospital

Diabetes June 2009, Vol.58, 1879-1886. doi:https://doi.org/10.2337/db08-1706

Apolipoprotein B but not LDL Cholesterol Is Associated With Coronary Artery Calcification in Type 2 Diabetic Whites

Seth S. Martin; Atif N. Qasim; Nehal N. Mehta; Megan Wolfe; Karen Terembula; Stanley Schwartz; Nayyar Iqbal; Mark Schutta; Roshanak Bagheri; Muredach P. Reilly

Abstracts

View articletitled, Apolipoprotein B but not LDL Cholesterol Is Associated With Coronary Artery Calcification in Type 2 Diabetic Whites

Supplementary data

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Topics: apolipoproteins b , ldl cholesterol lipoproteins , cholesterol , coronary arteriosclerosis , diabetes mellitus, type 2

Diabetes June 2009, Vol.58, 1887-1892. doi:https://doi.org/10.2337/db08-1794

Complications

In Vivo Activation of AMP-Activated Protein Kinase Attenuates Diabetes-Enhanced Degradation of GTP Cyclohydrolase I

Shuangxi Wang; Jian Xu; Ping Song; Benoit Viollet; Ming-Hui Zou

Abstracts

View articletitled, In Vivo Activation of AMP-Activated Protein Kinase Attenuates Diabetes-Enhanced Degradation of GTP Cyclohydrolase I

Supplementary data

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Topics: ampk , aorta , endothelium , glucose , metformin

Diabetes June 2009, Vol.58, 1893-1901. doi:https://doi.org/10.2337/db09-0267

Nanoparticle-Mediated Expression of an Angiogenic Inhibitor Ameliorates Ischemia-Induced Retinal Neovascularization and Diabetes-Induced Retinal Vascular Leakage

Kyoungmin Park; Ying Chen; Yang Hu; Aaron S. Mayo; Uday B. Kompella; Richard Longeras; Jian-xing Ma

Abstracts

View articletitled, Nanoparticle-Mediated Expression of an Angiogenic Inhibitor Ameliorates Ischemia-Induced Retinal Neovascularization and Diabetes-Induced Retinal Vascular Leakage

Supplementary data

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Topics: angiogenesis , eye , immunohistochemistry , intravitreal injections , ischemia

Diabetes June 2009, Vol.58, 1902-1913. doi:https://doi.org/10.2337/db08-1327

Adult Stature and Diabetes Complications in Patients With Type 1 Diabetes: The FinnDiane Study and the Diabetes Control and Complications Trial

Johan Wadén; Carol Forsblom; Lena M. Thorn; Markku Saraheimo; Milla Rosengård-Bärlund; Outi Heikkilä; Kustaa Hietala; Ken Ong; Nicholas Wareham; Per-Henrik Groop; on behalf of the FinnDiane Study Group

Abstracts

View articletitled, Adult Stature and Diabetes Complications in Patients With Type 1 Diabetes: The FinnDiane Study and the Diabetes Control and Complications Trial

Supplementary data

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Topics: dcct trial , diabetes mellitus complications , diabetes mellitus, type 1 , diabetic nephropathy , retinal diseases

Diabetes June 2009, Vol.58, 1914-1920. doi:https://doi.org/10.2337/db08-1767

Pharmacology & Therapeutics

Effect of Homocysteine-Lowering Treatment With Folic Acid and B Vitamins on Risk of Type 2 Diabetes in Women: A Randomized, Controlled Trial

Yiqing Song; Nancy R. Cook; Christine M. Albert; Martin Van Denburgh; JoAnn E. Manson

Abstracts

View articletitled, Effect of Homocysteine-Lowering Treatment With Folic Acid and B Vitamins on Risk of Type 2 Diabetes in Women: A Randomized, Controlled Trial

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Topics: diabetes mellitus, type 2 , folic acid , follow-up , homocysteine , vitamin b complex

Diabetes June 2009, Vol.58, 1921-1928. doi:https://doi.org/10.2337/db09-0087

Genetics

Identification of a Novel β-Cell Glucokinase (GCK) Promoter Mutation (−71G>C) That Modulates GCK Gene Expression Through Loss of Allele-Specific Sp1 Binding Causing Mild Fasting Hyperglycemia in Humans

Daniela Gašperíková; Nicolas D. Tribble; Juraj Staník; Miroslava Hučková; Nadežda Mišovicová; Martijn van de Bunt; Lucia Valentínová; Beryl A. Barrow; L'ubomir Barák; Radoslav Dobránsky; Eva Bereczková; Jozef Michálek; Kate Wicks; Kevin Colclough; Julian C. Knight; Sian Ellard; Iwar Klimeš; Anna L. Gloyn

Abstracts

View articletitled, Identification of a Novel β-Cell Glucokinase (GCK) Promoter Mutation (−71G>C) That Modulates GCK Gene Expression Through Loss of Allele-Specific Sp1 Binding Causing Mild Fasting Hyperglycemia in Humans

Supplementary data

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Topics: fasting , hyperglycemia , mutation , glucokinase , luciferases

Diabetes May 2009, Vol.58, 1929-1935. doi:https://doi.org/10.2337/db09-0070

Erratum

Errata

Extract

View articletitled, Errata

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Topics: gene expression , glucocorticoid receptors , intestines , stomach , rna, messenger

Diabetes August 2009, Vol.58, 1936. doi:https://doi.org/10.2337/db09-er08

Errata

Extract

View articletitled, Errata

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Topics: aortic valve , calcium , metabolic syndrome x , multi-ethnic study of atherosclerosis , data analysis

Diabetes August 2009, Vol.58, 1937. doi:https://doi.org/10.2337/db09-er08b

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