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Original Article
Metabolism
Grp78 Heterozygosity Promotes Adaptive Unfolded Protein Response and Attenuates Diet-Induced Obesity and Insulin Resistance
Risheng Ye; Dae Young Jung; John Y. Jun; Jianze Li; Shengzhan Luo; Hwi Jin Ko; Jason K. Kim; Amy S. Lee
Diabetes October 2009, Vol.59, 6-16. doi:https://doi.org/10.2337/db09-0755
Leucine Deprivation Decreases Fat Mass by Stimulation of Lipolysis in White Adipose Tissue and Upregulation of Uncoupling Protein 1 (UCP1) in Brown Adipose Tissue
Ying Cheng; Qingshu Meng; Chunxia Wang; Houkai Li; Zhiying Huang; Shanghai Chen; Fei Xiao; Feifan Guo
Diabetes October 2009, Vol.59, 17-25. doi:https://doi.org/10.2337/db09-0929
Low Muscle Glycogen and Elevated Plasma Free Fatty Acid Modify but Do Not Prevent Exercise-Induced PDH Activation in Human Skeletal Muscle
Kristian Kiilerich; Mikkel Gudmundsson; Jesper B. Birk; Carsten Lundby; Sarah Taudorf; Peter Plomgaard; Bengt Saltin; Per A. Pedersen; Jorgen F.P. Wojtaszewski; Henriette Pilegaard
Diabetes October 2009, Vol.59, 26-32. doi:https://doi.org/10.2337/db09-1032
Proteomics Analysis of Human Skeletal Muscle Reveals Novel Abnormalities in Obesity and Type 2 Diabetes
Hyonson Hwang; Benjamin P. Bowen; Natalie Lefort; Charles R. Flynn; Elena A. De Filippis; Christine Roberts; Christopher C. Smoke; Christian Meyer; Kurt Højlund; Zhengping Yi; Lawrence J. Mandarino
Diabetes October 2009, Vol.59, 33-42. doi:https://doi.org/10.2337/db09-0214
Insulin Causes Hyperthermia by Direct Inhibition of Warm-Sensitive Neurons
Manuel Sanchez-Alavez; Iustin V. Tabarean; Olivia Osborn; Kayo Mitsukawa; Jean Schaefer; Jeffrey Dubins; Kristina H. Holmberg; Izabella Klein; Joe Klaus; Luis F. Gomez; Hartmuth Kolb; James Secrest; Jeanine Jochems; Kevin Myashiro; Peter Buckley; John R. Hadcock; James Eberwine; Bruno Conti; Tamas Bartfai
Diabetes October 2009, Vol.59, 43-50. doi:https://doi.org/10.2337/db09-1128
Signal Transduction
Coadministration of Adenoviral Vascular Endothelial Growth Factor and Angiopoietin-1 Enhances Vascularization and Reduces Ventricular Remodeling in the Infarcted Myocardium of Type 1 Diabetic Rats
Samson Mathews Samuel; Yuzo Akita; Debayon Paul; Mahesh Thirunavukkarasu; Lijun Zhan; Perumana R. Sudhakaran; Chuanfu Li; Nilanjana Maulik
Diabetes September 2009, Vol.59, 51-60. doi:https://doi.org/10.2337/db09-0336
Tpl2 Kinase Is Upregulated in Adipose Tissue in Obesity and May Mediate Interleukin-1β and Tumor Necrosis Factor-α Effects on Extracellular Signal–Regulated Kinase Activation and Lipolysis
Jennifer Jager; Thierry Grémeaux; Teresa Gonzalez; Stéphanie Bonnafous; Cyrille Debard; Martine Laville; Hubert Vidal; Albert Tran; Philippe Gual; Yannick Le Marchand-Brustel; Mireille Cormont; Jean-François Tanti
Diabetes October 2009, Vol.59, 61-70. doi:https://doi.org/10.2337/db09-0470
Obesity Studies
Sympathetic Neural Adaptation to Hypocaloric Diet With or Without Exercise Training in Obese Metabolic Syndrome Subjects
Nora E. Straznicky; Elisabeth A. Lambert; Paul J. Nestel; Mariee T. McGrane; Tye Dawood; Markus P. Schlaich; Kazuko Masuo; Nina Eikelis; Barbora de Courten; Justin A. Mariani; Murray D. Esler; Florentia Socratous; Reena Chopra; Carolina I. Sari; Eldho Paul; Gavin W. Lambert
Diabetes October 2009, Vol.59, 71-79. doi:https://doi.org/10.2337/db09-0934
Insulin Resistance Is Associated With Higher Intramyocellular Triglycerides in Type I but Not Type II Myocytes Concomitant With Higher Ceramide Content
Paul M. Coen; John J. Dubé; Francesca Amati; Maja Stefanovic-Racic; Robert E. Ferrell; Frederico G.S. Toledo; Bret H. Goodpaster
Diabetes October 2009, Vol.59, 80-88. doi:https://doi.org/10.2337/db09-0988
Age, Obesity, and Sex Effects on Insulin Sensitivity and Skeletal Muscle Mitochondrial Function
Diabetes October 2009, Vol.59, 89-97. doi:https://doi.org/10.2337/db09-0591
Chronic Maternal Dietary Chromium Restriction Modulates Visceral Adiposity: Probable Underlying Mechanisms
Inagadapa J.N. Padmavathi; K. Rajender Rao; Lagishetty Venu; Manisha Ganeshan; K. Anand Kumar; Ch. Narasima Rao; Nemani Harishankar; Ayesha Ismail; Manchala Raghunath
Diabetes October 2009, Vol.59, 98-104. doi:https://doi.org/10.2337/db09-0779
Adipocyte Turnover: Relevance to Human Adipose Tissue Morphology
Erik Arner; Pål O. Westermark; Kirsty L. Spalding; Tom Britton; Mikael Rydén; Jonas Frisén; Samuel Bernard; Peter Arner
Diabetes October 2009, Vol.59, 105-109. doi:https://doi.org/10.2337/db09-0942
Immunology and Transplantation
Infection With Viruses From Several Families Triggers Autoimmune Diabetes in LEW.1WR1 Rats: Prevention of Diabetes by Maternal Immunization
Rebecca S. Tirabassi; Dennis L. Guberski; Elizabeth P. Blankenhorn; Jean H. Leif; Bruce A. Woda; Zhijun Liu; Donald Winans; Dale L. Greiner; John P. Mordes
Diabetes September 2009, Vol.59, 110-118. doi:https://doi.org/10.2337/db09-0255
Islet Studies
Overexpression of Kinase-Negative Protein Kinase Cδ in Pancreatic β-Cells Protects Mice From Diet-Induced Glucose Intolerance and β-Cell Dysfunction
Anita M. Hennige; Felicia Ranta; Isabel Heinzelmann; Martina Düfer; Diana Michael; Heidi Braumüller; Stefan Z. Lutz; Reiner Lammers; Gisela Drews; Fatima Bosch; Hans-Ulrich Häring; Susanne Ullrich
Diabetes October 2009, Vol.59, 119-127. doi:https://doi.org/10.2337/db09-0512
ATP-Sensitive K+ Channel Mediates the Zinc Switch-Off Signal for Glucagon Response During Glucose Deprivation
Diabetes October 2009, Vol.59, 128-134. doi:https://doi.org/10.2337/db09-1098
Absence of p53-Dependent Apoptosis Combined With Nonhomologous End-Joining Deficiency Leads to a Severe Diabetic Phenotype in Mice
Diabetes October 2009, Vol.59, 135-142. doi:https://doi.org/10.2337/db09-0792
Gestational Diabetes Mellitus Resulting From Impaired β-Cell Compensation in the Absence of FoxM1, a Novel Downstream Effector of Placental Lactogen
Hongjie Zhang; Jia Zhang; Christine F. Pope; Laura A. Crawford; Rupangi C. Vasavada; Shubhada M. Jagasia; Maureen Gannon
Diabetes October 2009, Vol.59, 143-152. doi:https://doi.org/10.2337/db09-0050
Carbohydrate-Responsive Element-Binding Protein (ChREBP) Is a Negative Regulator of ARNT/HIF-1β Gene Expression in Pancreatic Islet β-Cells
Nafeesa A. Noordeen; Tarnjit K. Khera; Gao Sun; E. Rebecca Longbottom; Timothy J. Pullen; Gabriela da Silva Xavier; Guy A. Rutter; Isabelle Leclerc
Diabetes October 2009, Vol.59, 153-160. doi:https://doi.org/10.2337/db08-0868
Pathophysiology
Tetracycline Treatment Retards the Onset and Slows the Progression of Diabetes in Human Amylin/Islet Amyloid Polypeptide Transgenic Mice
Jacqueline F. Aitken; Kerry M. Loomes; David W. Scott; Shivanand Reddy; Anthony R.J. Phillips; Gordana Prijic; Chathurini Fernando; Shaoping Zhang; Ric Broadhurst; Phil L'Huillier; Garth J.S. Cooper
Diabetes September 2009, Vol.59, 161-171. doi:https://doi.org/10.2337/db09-0548
Experimental Endotoxemia Induces Adipose Inflammation and Insulin Resistance in Humans
Nehal N. Mehta; Fiona C. McGillicuddy; Paul D. Anderson; Christine C. Hinkle; Rachana Shah; Leticia Pruscino; Jennifer Tabita-Martinez; Kim F. Sellers; Michael R. Rickels; Muredach P. Reilly
Diabetes September 2009, Vol.59, 172-181. doi:https://doi.org/10.2337/db09-0367
Attenuated Purinergic Receptor Function in Patients With Type 2 Diabetes
Diabetes October 2009, Vol.59, 182-189. doi:https://doi.org/10.2337/db09-1068
Nephrin Is Expressed on the Surface of Insulin Vesicles and Facilitates Glucose-Stimulated Insulin Release
Alessia Fornoni; Jongmin Jeon; Javier Varona Santos; Lorenzo Cobianchi; Alexandra Jauregui; Luca Inverardi; Slavena A. Mandic; Christina Bark; Kevin Johnson; George McNamara; Antonello Pileggi; R. Damaris Molano; Jochen Reiser; Karl Tryggvason; Dontscho Kerjaschki; Per-Olof Berggren; Peter Mundel; Camillo Ricordi
Diabetes October 2009, Vol.59, 190-199. doi:https://doi.org/10.2337/db09-0655
Complement Factor H Is Expressed in Adipose Tissue in Association With Insulin Resistance
José María Moreno-Navarrete; Rubén Martínez-Barricarte; Victoria Catalán; Mònica Sabater; Javier Gómez-Ambrosi; Francisco José Ortega; Wifredo Ricart; Mathias Blüher; Gema Frühbeck; Santiago Rodríguez de Cordoba; José Manuel Fernández-Real
Diabetes October 2009, Vol.59, 200-209. doi:https://doi.org/10.2337/db09-0700
Age at Onset of Type 1 Diabetes in Parents and Recurrence Risk in Offspring
Diabetes October 2009, Vol.59, 210-214. doi:https://doi.org/10.2337/db09-0344
Chronic Peripheral Hyperinsulinemia in Type 1 Diabetic Patients After Successful Combined Pancreas-Kidney Transplantation Does Not Affect Ectopic Lipid Accumulation in Skeletal Muscle and Liver
Marietta Stadler; Christian Anderwald; Giovanni Pacini; Štefan Zbýň; Miriam Promintzer-Schifferl; Martina Mandl; Martin Bischof; Stephan Gruber; Peter Nowotny; Anton Luger; Rudolf Prager; Michael Krebs
Diabetes October 2009, Vol.59, 215-218. doi:https://doi.org/10.2337/db09-0354
Complications
Remodeling of Retinal Fatty Acids in an Animal Model of Diabetes: A Decrease in Long-Chain Polyunsaturated Fatty Acids Is Associated With a Decrease in Fatty Acid Elongases Elovl2 and Elovl4
Maria Tikhonenko; Todd A. Lydic; Yun Wang; Weiqin Chen; Madalina Opreanu; Andrew Sochacki; Kelly M. McSorley; Rebecca L. Renis; Timothy Kern; Donald B. Jump; Gavin E. Reid; Julia V. Busik
Diabetes October 2009, Vol.59, 219-227. doi:https://doi.org/10.2337/db09-0728
Adaptive Cerebral Neovascularization in a Model of Type 2 Diabetes: Relevance to Focal Cerebral Ischemia
Weiguo Li; Roshini Prakash; Aisha I. Kelly-Cobbs; Safia Ogbi; Anna Kozak; Azza B. El-Remessy; Derek A. Schreihofer; Susan C. Fagan; Adviye Ergul
Diabetes October 2009, Vol.59, 228-235. doi:https://doi.org/10.2337/db09-0902
Hippocampal Volumes in Youth With Type 1 Diabetes
Diabetes October 2009, Vol.59, 236-241. doi:https://doi.org/10.2337/db09-1117
Adiposity, Cardiometabolic Risk, and Vitamin D Status: The Framingham Heart Study
Susan Cheng; Joseph M. Massaro; Caroline S. Fox; Martin G. Larson; Michelle J. Keyes; Elizabeth L. McCabe; Sander J. Robins; Christopher J. O'Donnell; Udo Hoffmann; Paul F. Jacques; Sarah L. Booth; Ramachandran S. Vasan; Myles Wolf; Thomas J. Wang
Diabetes October 2009, Vol.59, 242-248. doi:https://doi.org/10.2337/db09-1011
Hyperglycemia-Induced Reactive Oxygen Species Increase Expression of the Receptor for Advanced Glycation End Products (RAGE) and RAGE Ligands
Diabetes October 2009, Vol.59, 249-255. doi:https://doi.org/10.2337/db09-0801
Pharmacology and Therapeutics
High-Throughput Assay for Modulators of Mitochondrial Membrane Potential Identifies a Novel Compound With Beneficial Effects on db/db Mice
Bei-Ying Qiu; Nigel Turner; Yuan-Yuan Li; Min Gu; Meng-Wei Huang; Fang Wu; Tao Pang; Fa-Jun Nan; Ji-Ming Ye; Jing-Ya Li; Jia Li
Diabetes October 2009, Vol.59, 256-265. doi:https://doi.org/10.2337/db09-0223
Genetics
Polygenic Risk Variants for Type 2 Diabetes Susceptibility Modify Age at Diagnosis in Monogenic HNF1A Diabetes
Hana Lango Allen; Stefan Johansson; Sian Ellard; Beverley Shields; Jens K. Hertel; Helge Ræder; Kevin Colclough; Anders Molven; Timothy M. Frayling; Pål R. Njølstad; Andrew T. Hattersley; Michael N. Weedon
Diabetes September 2009, Vol.59, 266-271. doi:https://doi.org/10.2337/db09-0555
Idd9.1 Locus Controls the Suppressive Activity of FoxP3+CD4+CD25+ Regulatory T-Cells
Jun Yamanouchi; Maria-Carmen Puertas; Joan Verdaguer; Paul A. Lyons; Daniel B. Rainbow; Giselle Chamberlain; Kara M. Hunter; Laurence B. Peterson; Linda S. Wicker; Pere Santamaria
Diabetes October 2009, Vol.59, 272-281. doi:https://doi.org/10.2337/db09-0648
Raised Late Pregnancy Glucose Concentrations in Mice Carrying Pups With Targeted Disruption of H19Δ13
Clive J. Petry; Mark L. Evans; Dianne L. Wingate; Ken K. Ong; Wolf Reik; Miguel Constância; David B. Dunger
Diabetes September 2009, Vol.59, 282-286. doi:https://doi.org/10.2337/db09-0757
Combined Risk Allele Score of Eight Type 2 Diabetes Genes Is Associated With Reduced First-Phase Glucose-Stimulated Insulin Secretion During Hyperglycemic Clamps
Leen M. ‘t Hart; Annemarie M. Simonis-Bik; Giel Nijpels; Timon W. van Haeften; Silke A. Schäfer; Jeanine J. Houwing-Duistermaat; Dorret I. Boomsma; Marlous J. Groenewoud; Erwin Reiling; Els C. van Hove; Michaela Diamant; Mark H.H. Kramer; Robert J. Heine; J. Antonie Maassen; Kerstin Kirchhoff; Fausto Machicao; Hans-Ulrich Häring; P. Eline Slagboom; Gonneke Willemsen; Elisabeth M. Eekhoff; Eco J. de Geus; Jacqueline M. Dekker; Andreas Fritsche
Diabetes October 2009, Vol.59, 287-292. doi:https://doi.org/10.2337/db09-0736
Gene Variants in the Novel Type 2 Diabetes Loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B Affect Different Aspects of Pancreatic β-Cell Function
Annemarie M. Simonis-Bik; Giel Nijpels; Timon W. van Haeften; Jeanine J. Houwing-Duistermaat; Dorret I. Boomsma; Erwin Reiling; Els C. van Hove; Michaela Diamant; Mark H.H. Kramer; Robert J. Heine; J. Antonie Maassen; P. Eline Slagboom; Gonneke Willemsen; Jacqueline M. Dekker; Elisabeth M. Eekhoff; Eco J. de Geus; Leen M. 't Hart
Diabetes October 2009, Vol.59, 293-301. doi:https://doi.org/10.2337/db09-1048
Prevalence of Loss-of-Function FTO Mutations in Lean and Obese Individuals
David Meyre; Karine Proulx; Hiroko Kawagoe-Takaki; Vincent Vatin; Ruth Gutiérrez-Aguilar; Debbie Lyon; Marcella Ma; Helene Choquet; Fritz Horber; Wim Van Hul; Luc Van Gaal; Beverley Balkau; Sophie Visvikis-Siest; François Pattou; I. Sadaf Farooqi; Vladimir Saudek; Stephen O'Rahilly; Philippe Froguel; Barbara Sedgwick; Giles S.H. Yeo
Diabetes October 2009, Vol.59, 311-318. doi:https://doi.org/10.2337/db09-0703
