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Issues
Perspectives in Diabetes
Hypoglycemia in Type 1 Diabetes
Topics:
glucose
,
hypoglycemia
Diabetes October 2010, Vol.59, 2333-2339. doi:https://doi.org/10.2337/db10-0103
β-Cell Growth and Regeneration: Replication Is Only Part of the Story
Topics:
endocrine pancreas
,
ligation
,
mice
,
pancreas
,
pancreatectomy
Diabetes October 2010, Vol.59, 2340-2348. doi:https://doi.org/10.2337/db10-0084
Commentaries
Early Programming of Later Health and Disease: Factors Acting During Prenatal Life Might Have Lifelong Consequences
Topics:
prenatal care
,
diabetes mellitus, type 2
Diabetes October 2010, Vol.59, 2349-2350. doi:https://doi.org/10.2337/db10-0878
Targeting Ceramide Synthesis to Reverse Insulin Resistance
Topics:
ceramides
,
insulin resistance
,
insulin
Diabetes October 2010, Vol.59, 2351-2353. doi:https://doi.org/10.2337/db10-0912
Activatin' Human Adipose Progenitors in Obesity
Topics:
activins
,
obesity
,
adipose tissue
Diabetes October 2010, Vol.59, 2354-2357. doi:https://doi.org/10.2337/db10-0923
ApoA-1 in Diabetes: Damaged Goods
Topics:
apolipoprotein a-i
,
atherosclerosis
Diabetes October 2010, Vol.59, 2358-2359. doi:https://doi.org/10.2337/db10-1040
New Methodologies and Databases
Homogeneous Insulin and C-Peptide Sensors for Rapid Assessment of Insulin and C-Peptide Secretion by the Islets
Topics:
c-peptide
,
insulin
,
sensor
,
antibodies
,
bodily secretions
Diabetes July 2010, Vol.59, 2360-2365. doi:https://doi.org/10.2337/db10-0088
Identification of De Novo Synthesized and Relatively Older Proteins: Accelerated Oxidative Damage to De Novo Synthesized Apolipoprotein A-1 in Type 1 Diabetes
Abdul Jaleel; Gregory C. Henderson; Benjamin J. Madden; Katherine A. Klaus; Dawn M. Morse; Srinivas Gopala; K. Sreekumaran Nair
Diabetes July 2010, Vol.59, 2366-2374. doi:https://doi.org/10.2337/db10-0371
Identification of a Serum-Induced Transcriptional Signature Associated With Type 1 Diabetes in the BioBreeding Rat
Mary Kaldunski; Shuang Jia; Rhonda Geoffrey; Joel Basken; Simon Prosser; Sanjay Kansra; John P. Mordes; Åke Lernmark; Xujing Wang; Martin J. Hessner
Topics:
diabetes mellitus, type 1
,
genes
,
rats
,
serum
,
transcription, genetic
Diabetes August 2010, Vol.59, 2375-2385. doi:https://doi.org/10.2337/db10-0372
Glucose Excursions Between States of Glycemia With Progression to Type 1 Diabetes in the Diabetes Prevention Trial–Type 1 (DPT-1)
Jay M. Sosenko; Jay S. Skyler; Jeffrey P. Krischer; Carla J. Greenbaum; Jeffrey Mahon; Lisa E. Rafkin; David Cuthbertson; Catherine Cowie; Kevan Herold; George Eisenbarth; Jerry P. Palmer; the Diabetes Prevention Trial–Type 1 Study Group
Topics:
c-peptide
,
diabetes mellitus, type 1
,
glucose
,
oral glucose tolerance test
,
diphtheria-tetanus-pertussis vaccine
Diabetes August 2010, Vol.59, 2386-2389. doi:https://doi.org/10.2337/db10-0534
Metabolism
Decreased IRS Signaling Impairs β-Cell Cycle Progression and Survival in Transgenic Mice Overexpressing S6K in β-Cells
Lynda Elghazi; Norman Balcazar; Manuel Blandino-Rosano; Corentin Cras-Méneur; Szabolcs Fatrai; Aaron P. Gould; Maggie M. Chi; Kelle H. Moley; Ernesto Bernal-Mizrachi
Topics:
insulin
,
mice
,
mice, transgenic
,
signal transduction
,
apoptosis
Diabetes July 2010, Vol.59, 2390-2399. doi:https://doi.org/10.2337/db09-0851
Exposure to the Chinese Famine in Early Life and the Risk of Hyperglycemia and Type 2 Diabetes in Adulthood
Yanping Li; Yuna He; Lu Qi; Vincent W. Jaddoe; Edith J.M. Feskens; Xiaoguang Yang; Guansheng Ma; Frank B. Hu
Topics:
diabetes mellitus, type 2
,
famine
,
fetus
,
hyperglycemia
,
child
Diabetes July 2010, Vol.59, 2400-2406. doi:https://doi.org/10.2337/db10-0385
G Protein–Coupled Receptor Kinase 2 Plays a Relevant Role in Insulin Resistance and Obesity
Lucia Garcia-Guerra; Iria Nieto-Vazquez; Rocio Vila-Bedmar; María Jurado-Pueyo; Guillermo Zalba; Javier Díez; Cristina Murga; Sonia Fernández-Veledo; Federico Mayor, Jr.; Margarita Lorenzo
Topics:
insulin
,
insulin resistance
,
mice
,
obesity
,
tumor necrosis factors
Diabetes July 2010, Vol.59, 2407-2417. doi:https://doi.org/10.2337/db10-0771
Central Nervous System Delivery of the Antipsychotic Olanzapine Induces Hepatic Insulin Resistance
Topics:
agouti-related protein
,
antipsychotic agents
,
central nervous system
,
glucose
,
hypothalamus
Diabetes August 2010, Vol.59, 2418-2425. doi:https://doi.org/10.2337/db10-0449
Downregulation of AMPK Accompanies Leucine- and Glucose-Induced Increases in Protein Synthesis and Insulin Resistance in Rat Skeletal Muscle
Asish K. Saha; X. Julia Xu; Ebony Lawson; Rosangela Deoliveira; Amanda E. Brandon; Edward W. Kraegen; Neil B. Ruderman
Topics:
ampk
,
glucose
,
leucine
,
mtor serine-threonine kinases
,
phosphorylation
Diabetes August 2010, Vol.59, 2426-2434. doi:https://doi.org/10.2337/db09-1870
Hypothalamic AMP-Activated Protein Kinase Regulates Glucose Production
Clair S. Yang; Carol K.L. Lam; Madhu Chari; Grace W.C. Cheung; Andrea Kokorovic; Sun Gao; Isabelle Leclerc; Guy A. Rutter; Tony K.T. Lam
Topics:
ampk
,
glucose
,
hypothalamus
,
lactates
Diabetes August 2010, Vol.59, 2435-2443. doi:https://doi.org/10.2337/db10-0221
Increased Reactive Oxygen Species Production and Lower Abundance of Complex I Subunits and Carnitine Palmitoyltransferase 1B Protein Despite Normal Mitochondrial Respiration in Insulin-Resistant Human Skeletal Muscle
Natalie Lefort; Brian Glancy; Benjamin Bowen; Wayne T. Willis; Zachary Bailowitz; Elena A. De Filippis; Colleen Brophy; Christian Meyer; Kurt Højlund; Zhengping Yi; Lawrence J. Mandarino
Topics:
insulin
,
mitochondria
,
obesity
,
mass spectrometry
,
skeletal muscles
Diabetes August 2010, Vol.59, 2444-2452. doi:https://doi.org/10.2337/db10-0174
Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption
John R. Ussher; Timothy R. Koves; Virgilio J.J. Cadete; Liyan Zhang; Jagdip S. Jaswal; Suzanne J. Swyrd; David G. Lopaschuk; Spencer D. Proctor; Wendy Keung; Deborah M. Muoio; Gary D. Lopaschuk
Topics:
ceramides
,
diet
,
insulin
,
insulin resistance
,
mice
Diabetes June 2010, Vol.59, 2453-2464. doi:https://doi.org/10.2337/db09-1293
Femoral Adipose Tissue May Accumulate the Fat That Has Been Recycled as VLDL and Nonesterified Fatty Acids
Siobhán E. McQuaid; Sandy M. Humphreys; Leanne Hodson; Barbara A. Fielding; Fredrik Karpe; Keith N. Frayn
Topics:
abdomen
,
adipose tissue
,
fatty acids
,
lipoproteins, vldl
,
nonesterified fatty acids
Diabetes August 2010, Vol.59, 2465-2473. doi:https://doi.org/10.2337/db10-0678
Signal Transduction
Acute Stimulation of White Adipocyte Respiration by PKA-Induced Lipolysis
Topics:
adipocytes
,
cyclic amp
,
mitochondria
,
respiration
,
lipolysis
Diabetes August 2010, Vol.59, 2474-2483. doi:https://doi.org/10.2337/db10-0245
Obesity Studies
Genetic Link Between Obesity and MMP14-Dependent Adipogenic Collagen Turnover
Tae-Hwa Chun; Mayumi Inoue; Hiroko Morisaki; Itaru Yamanaka; Yoshihiro Miyamoto; Tomonori Okamura; Kaori Sato-Kusubata; Stephen J. Weiss
Topics:
adipose tissue
,
collagen
,
collagenolysis
,
diet
,
diet, high-fat
Diabetes July 2010, Vol.59, 2484-2494. doi:https://doi.org/10.2337/db10-0073
Antiobesity Effect of Eicosapentaenoic Acid in High-Fat/High-Sucrose Diet–Induced Obesity: Importance of Hepatic Lipogenesis
Ayumi Sato; Hiroyuki Kawano; Tatsuto Notsu; Masahiko Ohta; Masanori Nakakuki; Kiyoshi Mizuguchi; Michiko Itoh; Takayoshi Suganami; Yoshihiro Ogawa
Topics:
heart failure
,
obesity
,
triglycerides
,
diet
Diabetes August 2010, Vol.59, 2495-2504. doi:https://doi.org/10.2337/db09-1554
Antiobesity and Antihyperglycemic Effects of Ginsenoside Rb1 in Rats
Ye Xiong; Ling Shen; Kristina J. Liu; Patrick Tso; Yuqing Xiong; Guangji Wang; Stephen C. Woods; Min Liu
Diabetes August 2010, Vol.59, 2505-2512. doi:https://doi.org/10.2337/db10-0315
Activin A Plays a Critical Role in Proliferation and Differentiation of Human Adipose Progenitors
Laure-Emmanuelle Zaragosi; Brigitte Wdziekonski; Phi Villageois; Mayoura Keophiphath; Marie Maumus; Tamara Tchkonia; Virginie Bourlier; Tala Mohsen-Kanson; Annie Ladoux; Christian Elabd; Marcel Scheideler; Zlatko Trajanoski; Yasuhiro Takashima; Ez-Zoubir Amri; Daniele Lacasa; Coralie Sengenes; Gérard Ailhaud; Karine Clément; Anne Bouloumie; James L. Kirkland; Christian Dani
Topics:
activins
,
adipose tissue
,
obesity
Diabetes June 2010, Vol.59, 2513-2521. doi:https://doi.org/10.2337/db10-0013
Islet Studies
Gαo Represses Insulin Secretion by Reducing Vesicular Docking in Pancreatic β-Cells
Aizhen Zhao; Mica Ohara-Imaizumi; Marcella Brissova; Richard K.P. Benninger; Yanwen Xu; Yuhan Hao; Joel Abramowitz; Guylain Boulay; Alvin C. Powers; David Piston; Meisheng Jiang; Shinya Nagamatsu; Lutz Birnbaumer; Guoqiang Gu
Topics:
cell membrane
,
endocrine pancreas
,
glucose
,
granules
,
insulin
Diabetes July 2010, Vol.59, 2522-2529. doi:https://doi.org/10.2337/db09-1719
MafA and MafB Regulate Genes Critical to β-Cells in a Unique Temporal Manner
Isabella Artner; Yan Hang; Magdalena Mazur; Tsunehiko Yamamoto; Min Guo; Jill Lindner; Mark A. Magnuson; Roland Stein
Diabetes July 2010, Vol.59, 2530-2539. doi:https://doi.org/10.2337/db10-0190
Angiotensin I–Converting Enzyme Type 2 (ACE2) Gene Therapy Improves Glycemic Control in Diabetic Mice
Topics:
insulin
,
mice
,
pancreas
,
glycemic control
,
gene therapy
Diabetes July 2010, Vol.59, 2540-2548. doi:https://doi.org/10.2337/db09-0782
Immunology and Transplantation
Roles of Bcl-3 in the Pathogenesis of Murine Type 1 Diabetes
Topics:
bcl3 protein
,
mice
,
diabetes mellitus, type 1
,
cytokine
Diabetes July 2010, Vol.59, 2549-2557. doi:https://doi.org/10.2337/db10-0480
Mesenchymal Stem Cells Enhance Allogeneic Islet Engraftment in Nonhuman Primates
Dora M. Berman; Melissa A. Willman; Dongmei Han; Gary Kleiner; Norman M. Kenyon; Over Cabrera; Julie A. Karl; Roger W. Wiseman; David H. O'Connor; Amelia M. Bartholomew; Norma S. Kenyon
Topics:
chimerism
,
c-peptide
,
donors
,
engraftment
,
insulin
Diabetes July 2010, Vol.59, 2558-2568. doi:https://doi.org/10.2337/db10-0136
Clinical and Experimental Pancreatic Islet Transplantation to Striated Muscle: Establishment of a Vascular System Similar to That in Native Islets
Gustaf Christoffersson; Johanna Henriksnäs; Lars Johansson; Charlotte Rolny; Håkan Ahlström; José Caballero-Corbalan; Ralf Segersvärd; Johan Permert; Olle Korsgren; Per-Ola Carlsson; Mia Phillipson
Topics:
islets of langerhans transplantation
,
mice
,
muscle, striated
,
tissue transplants
,
transplantation
Diabetes July 2010, Vol.59, 2569-2578. doi:https://doi.org/10.2337/db10-0205
Insulin Transactivator MafA Regulates Intrathymic Expression of Insulin and Affects Susceptibility to Type 1 Diabetes
Shinsuke Noso; Kohsuke Kataoka; Yumiko Kawabata; Naru Babaya; Yoshihisa Hiromine; Kaori Yamaji; Tomomi Fujisawa; Shinsaku Aramata; Takashi Kudo; Satoru Takahashi; Hiroshi Ikegami
Topics:
diabetes mellitus, type 1
,
insulin
,
mice, inbred nod
,
thymus gland
,
trans-activators
Diabetes August 2010, Vol.59, 2579-2587. doi:https://doi.org/10.2337/db10-0476
Unexpected Acceleration of Type 1 Diabetes by Transgenic Expression of B7-H1 in NOD Mouse Peri-Islet Glia
Jason Yantha; Hubert Tsui; Shawn Winer; Aihua Song; Ping Wu; Geoff Paltser; James Ellis; H.-Michael Dosch
Topics:
animals, transgenic
,
codon, nonsense
,
diabetes mellitus, type 1
,
glial fibrillary acidic protein
,
mice, inbred nod
Diabetes June 2010, Vol.59, 2588-2596. doi:https://doi.org/10.2337/db09-1209
Pathophysiology
In Utero Exposure to Maternal Diabetes Impairs Vascular Expression of Prostacyclin Receptor in Rat Offspring
Jean-Paul Duong Van Huyen; Emilie Vessières; Claudine Perret; Adrien Troise; Sonia Prince; Anne-Laure Guihot; Pascal Barbry; Daniel Henrion; Patrick Bruneval; Stéphane Laurent; Martine Lelièvre-Pégorier; Céline Fassot
Topics:
arachidonic acid
,
chronic multifocal osteomyelitis
,
descending thoracic aorta
,
epoprostenol
,
gestational diabetes
Diabetes July 2010, Vol.59, 2597-2602. doi:https://doi.org/10.2337/db10-0311
NOX2 Deficiency Protects Against Streptozotocin-Induced β-Cell Destruction and Development of Diabetes in Mice
Topics:
cybb gene
,
insulin
,
mice
,
streptozocin
,
cytokine
Diabetes July 2010, Vol.59, 2603-2611. doi:https://doi.org/10.2337/db09-1562
Blockade of Endothelial-Mesenchymal Transition by a Smad3 Inhibitor Delays the Early Development of Streptozotocin-Induced Diabetic Nephropathy
Jinhua Li; Xinli Qu; Jun Yao; Georgina Caruana; Sharon D. Ricardo; Yasuhiko Yamamoto; Hiroshi Yamamoto; John F. Bertram
Topics:
diabetic nephropathy
,
fibrosis
,
kidney
,
mice
,
microscopy, confocal
Diabetes August 2010, Vol.59, 2612-2624. doi:https://doi.org/10.2337/db09-1631
Detailed Physiological Characterization of the Development of Type 2 Diabetes in Hispanic Women With Prior Gestational Diabetes Mellitus
Topics:
diabetes mellitus, type 2
,
follow-up
,
gestational diabetes
,
glucose
,
insulin
Diabetes August 2010, Vol.59, 2625-2630. doi:https://doi.org/10.2337/db10-0521
Complications
Fetal Exposure to Maternal Type 1 Diabetes Is Associated With Renal Dysfunction at Adult Age
Charbel Abi Khalil; Florence Travert; Sabrina Fetita; François Rouzet; Raphael Porcher; Jean-Pierre Riveline; Samy Hadjadj; Etienne Larger; Ronan Roussel; Patrick Vexiau; Dominique Le Guludec; Jean-François Gautier; Michel Marre
Topics:
amino acids
,
birth weight
,
diabetes mellitus, type 1
,
hyperglycemia
,
kidney
Diabetes July 2010, Vol.59, 2631-2636. doi:https://doi.org/10.2337/db10-0419
Calcium Dobesilate Inhibits the Alterations in Tight Junction Proteins and Leukocyte Adhesion to Retinal Endothelial Cells Induced by Diabetes
Ermelindo C. Leal; João Martins; Paula Voabil; Joana Liberal; Carlo Chiavaroli; Jacques Bauer; José Cunha-Vaz; António F. Ambrósio
Topics:
computer assisted diagnosis
,
computer-aided detection systems
,
coronary arteriosclerosis
,
endothelial cells
,
retinal vessels
Diabetes July 2010, Vol.59, 2637-2645. doi:https://doi.org/10.2337/db09-1421
The Medial Amygdalar Nucleus: A Novel Glucose-Sensing Region That Modulates the Counterregulatory Response to Hypoglycemia
Ligang Zhou; Nina Podolsky; Zhen Sang; Yuyan Ding; Xiaoning Fan; Qingchun Tong; Barry E. Levin; Rory J. McCrimmon
Topics:
glucose
,
hypoglycemia
,
neurons
,
glucokinase
Diabetes July 2010, Vol.59, 2646-2652. doi:https://doi.org/10.2337/db09-0995
Pharmacology and Therapeutics
Chronic Administration of the Glucagon-Like Peptide-1 Analog, Liraglutide, Delays the Onset of Diabetes and Lowers Triglycerides in UCD-T2DM Rats
Bethany P. Cummings; Kimber L. Stanhope; James L. Graham; Denis G. Baskin; Steven C. Griffen; Cecilia Nilsson; Anette Sams; Lotte B. Knudsen; Kirsten Raun; Peter J. Havel
Topics:
liraglutide
,
insulin
,
diabetes mellitus, type 2
Diabetes July 2010, Vol.59, 2653-2661. doi:https://doi.org/10.2337/db09-1564
Genetics
Genetic and Functional Assessment of the Role of the rs13431652-A and rs573225-A Alleles in the G6PC2 Promoter That Are Strongly Associated With Elevated Fasting Glucose Levels
Nabila Bouatia-Naji; Amélie Bonnefond; Devin A. Baerenwald; Marion Marchand; Marco Bugliani; Piero Marchetti; François Pattou; Richard L. Printz; Brian P. Flemming; Obi C. Umunakwe; Nicholas L. Conley; Martine Vaxillaire; Olivier Lantieri; Beverley Balkau; Michel Marre; Claire Lévy-Marchal; Paul Elliott; Marjo-Riitta Jarvelin; David Meyre; Christian Dina; James K. Oeser; Philippe Froguel; Richard M. O'Brien
Topics:
alleles
,
binding (molecular function)
,
fasting blood glucose measurement
,
fusion genes
,
gel
Diabetes July 2010, Vol.59, 2662-2671. doi:https://doi.org/10.2337/db10-0389
Common Variants in 40 Genes Assessed for Diabetes Incidence and Response to Metformin and Lifestyle Intervention in the Diabetes Prevention Program
Kathleen A. Jablonski; Jarred B. McAteer; Paul I.W. de Bakker; Paul W. Franks; Toni I. Pollin; Robert L. Hanson; Richa Saxena; Sarah Fowler; Alan R. Shuldiner; William C. Knowler; David Altshuler; Jose C. Florez; for the Diabetes Prevention Program Research Group
Topics:
genes
,
life style
,
metformin
,
single nucleotide polymorphism
,
diabetes prevention
Diabetes August 2010, Vol.59, 2672-2681. doi:https://doi.org/10.2337/db10-0543
Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: Common Genetic Variants in GCK and TCF7L2 Are Associated With Fasting and Postchallenge Glucose Levels in Pregnancy and With the New Consensus Definition of Gestational Diabetes Mellitus From the International Association of Diabetes and Pregnancy Study Groups
Rachel M. Freathy; M. Geoffrey Hayes; Margrit Urbanek; Lynn P. Lowe; Hoon Lee; Christine Ackerman; Timothy M. Frayling; Nancy J. Cox; David B. Dunger; Alan R. Dyer; Andrew T. Hattersley; Boyd E. Metzger; William L. Lowe, Jr; for the HAPO Study Cooperative Research Group
Topics:
birth weight
,
genotype
,
glucose
,
newborn
,
tcf7l2 gene
Diabetes August 2010, Vol.59, 2682-2689. doi:https://doi.org/10.2337/db10-0177
Large Copy-Number Variations Are Enriched in Cases With Moderate to Extreme Obesity
Topics:
obesity
,
obesity, morbid
,
copy number polymorphism
Diabetes July 2010, Vol.59, 2690-2694. doi:https://doi.org/10.2337/db10-0192
Errata
Errata
Topics:
diabetes mellitus, type 1
,
diabetic nephropathy
,
measurement scales
,
urate measurement, serum
Diabetes October 2010, Vol.59, 2695. doi:https://doi.org/10.2337/db10-er10a
Errata
Topics:
high density lipoprotein cholesterol
,
insulin resistance
,
mice
,
monoamine oxidase
,
nonesterified fatty acids
Diabetes October 2010, Vol.59, 2695. doi:https://doi.org/10.2337/db10-er10b
