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Issues
Banting Lecture
Pathogenesis of Fasting and Postprandial Hyperglycemia in Type 2 Diabetes: Implications for Therapy
Diabetes August 2010, Vol.59, 2697-2707. doi:https://doi.org/10.2337/db10-1032
Scientific Achievement Award Lecture
Outstanding Scientific Achievement Award Lecture 2010: Deconstructing Leptin: From Signals to Circuits
Diabetes November 2010, Vol.59, 2708-2714. doi:https://doi.org/10.2337/db10-1118
Perspectives in Diabetes
Physical Activity, Sedentary Behavior, and Health: Paradigm Paralysis or Paradigm Shift?
Diabetes November 2010, Vol.59, 2717-2725. doi:https://doi.org/10.2337/db10-0822
Commentaries
Final Answer: Ghrelin Can Suppress Insulin Secretion in Humans, but Is It Clinically Relevant?
Diabetes November 2010, Vol.59, 2726-2728. doi:https://doi.org/10.2337/db10-1088
Building Genetic Scores to Predict Risk of Complex Diseases in Humans: Is It Possible?
Diabetes November 2010, Vol.59, 2729-2731. doi:https://doi.org/10.2337/db10-1081
Metabolism
AMP-activated Protein Kinase α2 Subunit Is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids
Tomas Jelenik; Martin Rossmeisl; Ondrej Kuda; Zuzana Macek Jilkova; Dasa Medrikova; Vladimir Kus; Michal Hensler; Petra Janovska; Ivan Miksik; Marcin Baranowski; Jan Gorski; Sophie Hébrard; Thomas E. Jensen; Pavel Flachs; Simon Hawley; Benoit Viollet; Jan Kopecky
Diabetes August 2010, Vol.59, 2737-2746. doi:https://doi.org/10.2337/db09-1716
Liver Fat Content in Type 2 Diabetes: Relationship With Hepatic Perfusion and Substrate Metabolism
Luuk J. Rijzewijk; Rutger W. van der Meer; Mark Lubberink; Hildo J. Lamb; Johannes A. Romijn; Albert de Roos; Jos W. Twisk; Robert J. Heine; Adriaan A. Lammertsma; Johannes W.A. Smit; Michaela Diamant
Diabetes August 2010, Vol.59, 2747-2754. doi:https://doi.org/10.2337/db09-1201
Adipose Tissue Endothelial Cells From Obese Human Subjects: Differences Among Depots in Angiogenic, Metabolic, and Inflammatory Gene Expression and Cellular Senescence
Aurélie Villaret; Jean Galitzky; Pauline Decaunes; David Estève; Marie-Adeline Marques; Coralie Sengenès; Patrick Chiotasso; Tamara Tchkonia; Max Lafontan; James L. Kirkland; Anne Bouloumié
Diabetes August 2010, Vol.59, 2755-2763. doi:https://doi.org/10.2337/db10-0398
Pharmacological Vasodilation Improves Insulin-Stimulated Muscle Protein Anabolism but Not Glucose Utilization in Older Adults
Kyle L. Timmerman; Jessica L. Lee; Satoshi Fujita; Shaheen Dhanani; Hans C. Dreyer; Christopher S. Fry; Micah J. Drummond; Melinda Sheffield-Moore; Blake B. Rasmussen; Elena Volpi
Diabetes August 2010, Vol.59, 2764-2771. doi:https://doi.org/10.2337/db10-0415
Hypothalamic Angptl4/Fiaf Is a Novel Regulator of Food Intake and Body Weight
Hyun-Kyong Kim; Byung-Soo Youn; Mi-Seon Shin; Churl Namkoong; Kyeong Han Park; Ja Hyun Baik; Jae Bum Kim; Joong-Yeol Park; Ki-up Lee; Young-Bum Kim; Min-Seon Kim
Diabetes August 2010, Vol.59, 2772-2780. doi:https://doi.org/10.2337/db10-0145
Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State
ffolliott M. Fisher; Patricia C. Chui; Patrick J. Antonellis; Holly A. Bina; Alexei Kharitonenkov; Jeffrey S. Flier; Eleftheria Maratos-Flier
Diabetes August 2010, Vol.59, 2781-2789. doi:https://doi.org/10.2337/db10-0193
Impact of Physical Inactivity on Subcutaneous Adipose Tissue Metabolism in Healthy Young Male Offspring of Patients With Type 2 Diabetes
Lise Højbjerre; Mette Paulli Sonne; Amra Ciric Alibegovic; Flemming Dela; Allan Vaag; Jens Bruun Meldgaard; Karl Bang Christensen; Bente Stallknecht
Diabetes September 2010, Vol.59, 2790-2798. doi:https://doi.org/10.2337/db10-0320
Signal Transduction
INS-1 Cells Undergoing Caspase-Dependent Apoptosis Enhance the Regenerative Capacity of Neighboring Cells
Caroline Bonner; Siobhán Bacon; Caoimhín G. Concannon; Syed R. Rizvi; Mathurin Baquié; Angela M. Farrelly; Seán M. Kilbride; Heiko Dussmann; Manus W. Ward; Chantal M. Boulanger; Claes B. Wollheim; Rolf Graf; Maria M. Byrne; Jochen H.M. Prehn
Diabetes August 2010, Vol.59, 2799-2808. doi:https://doi.org/10.2337/db09-1478
Obesity Studies
DsbA-L Alleviates Endoplasmic Reticulum Stress–Induced Adiponectin Downregulation
Diabetes August 2010, Vol.59, 2809-2816. doi:https://doi.org/10.2337/db10-0412
Fibrosis in Human Adipose Tissue: Composition, Distribution, and Link With Lipid Metabolism and Fat Mass Loss
Adeline Divoux; Joan Tordjman; Danièle Lacasa; Nicolas Veyrie; Danielle Hugol; Abdelhalim Aissat; Arnaud Basdevant; Michèle Guerre-Millo; Christine Poitou; Jean-Daniel Zucker; Pierre Bedossa; Karine Clément
Diabetes August 2010, Vol.59, 2817-2825. doi:https://doi.org/10.2337/db10-0585
Cannabinoid Receptor Stimulation Impairs Mitochondrial Biogenesis in Mouse White Adipose Tissue, Muscle, and Liver: The Role of eNOS, p38 MAPK, and AMPK Pathways
Laura Tedesco; Alessandra Valerio; Marta Dossena; Annalisa Cardile; Maurizio Ragni; Claudio Pagano; Uberto Pagotto; Michele O. Carruba; Roberto Vettor; Enzo Nisoli
Diabetes August 2010, Vol.59, 2826-2836. doi:https://doi.org/10.2337/db09-1881
Evaluation of A2BP1 as an Obesity Gene
Lijun Ma; Robert L. Hanson; Michael T. Traurig; Yunhua L. Muller; Bakhshish P. Kaur; Jessica M. Perez; David Meyre; Mao Fu; Antje Körner; Paul W. Franks; Wieland Kiess; Sayuko Kobes; William C. Knowler; Peter Kovacs; Philippe Froguel; Alan R. Shuldiner; Clifton Bogardus; Leslie J. Baier
Diabetes August 2010, Vol.59, 2837-2845. doi:https://doi.org/10.2337/db09-1604
Islet Studies
Residual Insulin Production and Pancreatic β-Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study
Hillary A. Keenan; Jennifer K. Sun; Jared Levine; Alessandro Doria; Lloyd P. Aiello; George Eisenbarth; Susan Bonner-Weir; George L. King
Diabetes August 2010, Vol.59, 2846-2853. doi:https://doi.org/10.2337/db10-0676
Nuclear Hormone Retinoid X Receptor (RXR) Negatively Regulates the Glucose-Stimulated Insulin Secretion of Pancreatic β-Cells
Satsuki Miyazaki; Hidenori Taniguchi; Yusuke Moritoh; Fumi Tashiro; Tsunehiko Yamamoto; Eiji Yamato; Hiroshi Ikegami; Keiko Ozato; Jun-ichi Miyazaki
Diabetes August 2010, Vol.59, 2854-2861. doi:https://doi.org/10.2337/db09-1897
Immunology and Transplantation
Neutralization of Interleukin-16 Protects Nonobese Diabetic Mice From Autoimmune Type 1 Diabetes by a CCL4-Dependent Mechanism
Craig Meagher; Josh Beilke; Guillermo Arreaza; Qing-Sheng Mi; Wei Chen; Konstantin Salojin; Noah Horst; William W. Cruikshank; Terry L. Delovitch
Diabetes August 2010, Vol.59, 2862-2871. doi:https://doi.org/10.2337/db09-0131
Pathophysiology
TNF-α Signals Through PKCζ/NF-κB to Alter the Tight Junction Complex and Increase Retinal Endothelial Cell Permeability
Diabetes August 2010, Vol.59, 2872-2882. doi:https://doi.org/10.2337/db09-1606
Diabetic Retinopathy and Cognitive Decline in Older People With Type 2 Diabetes: The Edinburgh Type 2 Diabetes Study
Jie Ding; Mark W.J. Strachan; Rebecca M. Reynolds; Brian M. Frier; Ian J. Deary; F. Fowkes R. Gerald; Amanda J. Lee; Janet McKnight; Patricia Halpin; Ken Swa; Jackie F. Price; on behalf of the Edinburgh Type 2 Diabetes Study (ET2DS) Investigators
Diabetes August 2010, Vol.59, 2883-2889. doi:https://doi.org/10.2337/db10-0752
Pparg-P465L Mutation Worsens Hyperglycemia in Ins2-Akita Female Mice via Adipose-Specific Insulin Resistance and Storage Dysfunction
Diabetes November 2010, Vol.59, 2890-2897. doi:https://doi.org/10.2337/db10-0673
Expression of Human Chemerin Induces Insulin Resistance in the Skeletal Muscle but Does Not Affect Weight, Lipid Levels, and Atherosclerosis in LDL Receptor Knockout Mice on High-Fat Diet
Melanie Becker; Katja Rabe; Corinna Lebherz; Julia Zugwurst; Burkhard Göke; Klaus G. Parhofer; Michael Lehrke; Uli C. Broedl
Diabetes August 2010, Vol.59, 2898-2903. doi:https://doi.org/10.2337/db10-0362
Complications
Diabetic Nephropathy Is Accelerated by Farnesoid X Receptor Deficiency and Inhibited by Farnesoid X Receptor Activation in a Type 1 Diabetes Model
Xiaoxin X. Wang; Tao Jiang; Yan Shen; Yupanqui Caldas; Shinobu Miyazaki-Anzai; Hannah Santamaria; Cydney Urbanek; Nathaniel Solis; Pnina Scherzer; Linda Lewis; Frank J. Gonzalez; Luciano Adorini; Mark Pruzanski; Jeffrey B. Kopp; Jill W. Verlander; Moshe Levi
Diabetes August 2010, Vol.59, 2916-2927. doi:https://doi.org/10.2337/db10-0019
Accelerated Progression From Mild Cognitive Impairment to Dementia in People With Diabetes
Weili Xu; Barbara Caracciolo; Hui-Xin Wang; Bengt Winblad; Lars Bäckman; Chengxuan Qiu; Laura Fratiglioni
Diabetes August 2010, Vol.59, 2928-2935. doi:https://doi.org/10.2337/db10-0539
Insulin Reciprocally Regulates Glucagon Secretion in Humans
Diabetes September 2010, Vol.59, 2936-2940. doi:https://doi.org/10.2337/db10-0728
Glucagon Supports Postabsorptive Plasma Glucose Concentrations in Humans With Biologically Optimal Insulin Levels
Diabetes August 2010, Vol.59, 2941-2944. doi:https://doi.org/10.2337/db10-0750
Combined Effect of Inflammatory Gene Polymorphisms and the Risk of Ischemic Stroke in a Prospective Cohort of Subjects With Type 2 Diabetes: A Go-DARTS Study
Colin N.A. Palmer; Charlotte H. Kimber; Alex S.F. Doney; Anna S. Proia; Andrew D. Morris; Eleonora Gaetani; Miriam Quarta; Roy C. Smith; Roberto Pola
Diabetes July 2010, Vol.59, 2945-2948. doi:https://doi.org/10.2337/db09-1690
Adiponectin Prevents Diabetic Premature Senescence of Endothelial Progenitor Cells and Promotes Endothelial Repair by Suppressing the p38 MAP Kinase/p16INK4A Signaling Pathway
Junlei Chang; Yiming Li; Yu Huang; Karen S.L. Lam; Ruby L.C. Hoo; Wing Tak Wong; Kenneth K.Y. Cheng; Yiqun Wang; Paul M. Vanhoutte; Aimin Xu
Diabetes August 2010, Vol.59, 2949-2959. doi:https://doi.org/10.2337/db10-0582
Genetics
A Systems Biology Approach Identifies Inflammatory Abnormalities Between Mouse Strains Prior to Development of Metabolic Disease
Marcelo A. Mori; Manway Liu; Olivier Bezy; Katrine Almind; Hagit Shapiro; Simon Kasif; C. Ronald Kahn
Diabetes August 2010, Vol.59, 2960-2971. doi:https://doi.org/10.2337/db10-0367
HLA Class I and Genetic Susceptibility to Type 1 Diabetes: Results From the Type 1 Diabetes Genetics Consortium
Janelle A. Noble; Ana Maria Valdes; Michael D. Varney; Joyce A. Carlson; Priscilla Moonsamy; Anna Lisa Fear; Julie A. Lane; Eva Lavant; Rebecca Rappner; Anthony Louey; Patrick Concannon; Josyf C. Mychaleckyj; Henry A. Erlich; for the Type 1 Diabetes Genetics Consortium
Diabetes August 2010, Vol.59, 2972-2979. doi:https://doi.org/10.2337/db10-0699
Genetic Susceptibility to Obesity and Related Traits in Childhood and Adolescence: Influence of Loci Identified by Genome-Wide Association Studies
Marcel den Hoed; Ulf Ekelund; Søren Brage; Anders Grontved; Jing Hua Zhao; Stephen J. Sharp; Ken K. Ong; Nicholas J. Wareham; Ruth J.F. Loos
Diabetes August 2010, Vol.59, 2980-2988. doi:https://doi.org/10.2337/db10-0370
