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Issues
Commentaries
The Hypothalamus and β-Cell Connection in the Gene-Targeting Era
Diabetes December 2010, Vol.59, 2991-2993. doi:https://doi.org/10.2337/db10-1149
ACE2 and Diabetes: ACE of ACEs?
Diabetes December 2010, Vol.59, 2994-2996. doi:https://doi.org/10.2337/db10-1205
Metabolism
A Soluble Guanylate Cyclase–Dependent Mechanism Is Involved in the Regulation of Net Hepatic Glucose Uptake by Nitric Oxide in Vivo
Zhibo An; Jason J. Winnick; Ben Farmer; Doss Neal; Margaret Lautz; Jose M. Irimia; Peter J. Roach; Alan D. Cherrington
Diabetes September 2010, Vol.59, 2999-3007. doi:https://doi.org/10.2337/db10-0138
Intrinsic Depot-Specific Differences in the Secretome of Adipose Tissue, Preadipocytes, and Adipose Tissue–Derived Microvascular Endothelial Cells
Diabetes September 2010, Vol.59, 3008-3016. doi:https://doi.org/10.2337/db10-0483
First-Trimester Prediction of Gestational Diabetes Mellitus: Examining the Potential of Combining Maternal Characteristics and Laboratory Measures
Makrina Savvidou; Scott M. Nelson; Mahlatse Makgoba; Claudia-Martina Messow; Naveed Sattar; Kypros Nicolaides
Diabetes September 2010, Vol.59, 3017-3022. doi:https://doi.org/10.2337/db10-0688
Metformin Treatment May Increase Omentin-1 Levels in Women With Polycystic Ovary Syndrome
Diabetes September 2010, Vol.59, 3023-3031. doi:https://doi.org/10.2337/db10-0124
Disruption of Hepatic Leptin Signaling Protects Mice From Age- and Diet-Related Glucose Intolerance
Frank K. Huynh; Jasna Levi; Heather C. Denroche; Sarah L. Gray; Peter J. Voshol; Ursula H. Neumann; Madeleine Speck; Streamson C. Chua; Scott D. Covey; Timothy J. Kieffer
Diabetes September 2010, Vol.59, 3032-3040. doi:https://doi.org/10.2337/db10-0074
Regulation of Fasting Fuel Metabolism by Toll-Like Receptor 4
Diabetes September 2010, Vol.59, 3041-3048. doi:https://doi.org/10.2337/db10-0418
Obesity Studies
Differential Adaptation of Human Gut Microbiota to Bariatric Surgery–Induced Weight Loss: Links With Metabolic and Low-Grade Inflammation Markers
Jean-Pierre Furet; Ling-Chun Kong; Julien Tap; Christine Poitou; Arnaud Basdevant; Jean-Luc Bouillot; Denis Mariat; Gérard Corthier; Joël Doré; Corneliu Henegar; Salwa Rizkalla; Karine Clément
Diabetes September 2010, Vol.59, 3049-3057. doi:https://doi.org/10.2337/db10-0253
Maternal Antioxidant Supplementation Prevents Adiposity in the Offspring of Western Diet–Fed Rats
Diabetes September 2010, Vol.59, 3058-3065. doi:https://doi.org/10.2337/db10-0301
Associations of Six Single Nucleotide Polymorphisms in Obesity-Related Genes With BMI and Risk of Obesity in Chinese Children
Lijun Wu; Bo Xi; Meixian Zhang; Yue Shen; Xiaoyuan Zhao; Hong Cheng; Dongqing Hou; Dandan Sun; Jurg Ott; Xingyu Wang; Jie Mi
Diabetes September 2010, Vol.59, 3085-3089. doi:https://doi.org/10.2337/db10-0273
Islet Studies
Conditional Gene Targeting in Mouse Pancreatic β-Cells: Analysis of Ectopic Cre Transgene Expression in the Brain
Barton Wicksteed; Marcela Brissova; Wenbo Yan; Darren M. Opland; Jennifer L. Plank; Rachel B. Reinert; Lorna M. Dickson; Natalia A. Tamarina; Louis H. Philipson; Alena Shostak; Ernesto Bernal-Mizrachi; Lynda Elghazi; Michael W. Roe; Patricia A. Labosky; Martin G. Myers, Jr.; Maureen Gannon; Alvin C. Powers; Peter J. Dempsey
Diabetes August 2010, Vol.59, 3090-3098. doi:https://doi.org/10.2337/db10-0624
Novel Small Molecule Glucagon-Like Peptide-1 Receptor Agonist Stimulates Insulin Secretion in Rodents and From Human Islets
Kyle W. Sloop; Francis S. Willard; Martin B. Brenner; James Ficorilli; Kathleen Valasek; Aaron D. Showalter; Thomas B. Farb; Julia X.C. Cao; Amy L. Cox; M. Dodson Michael; Sonia Maria Gutierrez Sanfeliciano; Mark J. Tebbe; Michael J. Coghlan
Diabetes September 2010, Vol.59, 3099-3107. doi:https://doi.org/10.2337/db10-0689
In Vivo Expression of HGF/NK1 and GLP-1 From dsAAV Vectors Enhances Pancreatic β-Cell Proliferation and Improves Pathology in the db/db Mouse Model of Diabetes
Diabetes September 2010, Vol.59, 3108-3116. doi:https://doi.org/10.2337/db09-1886
Deletion of Pten in Pancreatic β-Cells Protects Against Deficient β-Cell Mass and Function in Mouse Models of Type 2 Diabetes
Linyuan Wang; Yunfeng Liu; Shun Yan Lu; Kinh-Tung T. Nguyen; Stephanie A. Schroer; Akira Suzuki; Tak W. Mak; Herbert Gaisano; Minna Woo
Diabetes September 2010, Vol.59, 3117-3126. doi:https://doi.org/10.2337/db09-1805
Effects of PNPLA3 on Liver Fat and Metabolic Profile in Hispanic Children and Adolescents
Michael I. Goran; Ryan Walker; Kim-Anne Le; Swapna Mahurkar; Susanna Vikman; Jaimie N. Davis; Donna Spruijt-Metz; Marc J. Weigensberg; Hooman Allayee
Diabetes September 2010, Vol.59, 3127-3130. doi:https://doi.org/10.2337/db10-0554
Parathyroid Hormone–Related Protein Enhances Human β-Cell Proliferation and Function With Associated Induction of Cyclin-Dependent Kinase 2 and Cyclin E Expression
Nagesha Guthalu Kondegowda; Sheela Joshi-Gokhale; George Harb; Katoura Williams; Xiao Ying Zhang; Karen K. Takane; Pili Zhang; Donald K. Scott; Andrew F. Stewart; Adolfo Garcia-Ocaña; Rupangi C. Vasavada
Diabetes September 2010, Vol.59, 3131-3138. doi:https://doi.org/10.2337/db09-1796
Immunology and Transplantation
Congenic Mesenchymal Stem Cell Therapy Reverses Hyperglycemia in Experimental Type 1 Diabetes
Mollie Jurewicz; Sunmi Yang; Andrea Augello; Jonathan G. Godwin; Robert F. Moore; Jamil Azzi; Paolo Fiorina; Mark Atkinson; Mohamed H. Sayegh; Reza Abdi
Diabetes September 2010, Vol.59, 3139-3147. doi:https://doi.org/10.2337/db10-0542
Virtual Optimization of Nasal Insulin Therapy Predicts Immunization Frequency to Be Crucial for Diabetes Protection
Georgia Fousteri; Jason R. Chan; Yanan Zheng; Chan Whiting; Amy Dave; Damien Bresson; Michael Croft; Matthias von Herrath
Diabetes September 2010, Vol.59, 3148-3158. doi:https://doi.org/10.2337/db10-0561
Pathophysiology
High Glucose Increases Lysyl Oxidase Expression and Activity in Retinal Endothelial Cells: Mechanism for Compromised Extracellular Matrix Barrier Function
Diabetes September 2010, Vol.59, 3159-3166. doi:https://doi.org/10.2337/db10-0365
Relationships of Circulating Sex Hormone–Binding Globulin With Metabolic Traits in Humans
Andreas Peter; Konstantinos Kantartzis; Jürgen Machann; Fritz Schick; Harald Staiger; Fausto Machicao; Erwin Schleicher; Andreas Fritsche; Hans-Ulrich Häring; Norbert Stefan
Diabetes September 2010, Vol.59, 3167-3173. doi:https://doi.org/10.2337/db10-0179
Enterovirus Infection and Progression From Islet Autoimmunity to Type 1 Diabetes: The Diabetes and Autoimmunity Study in the Young (DAISY)
Lars C. Stene; Sami Oikarinen; Heikki Hyöty; Katherine J. Barriga; Jill M. Norris; Georgeanna Klingensmith; John C. Hutton; Henry A. Erlich; George S. Eisenbarth; Marian Rewers
Diabetes September 2010, Vol.59, 3174-3180. doi:https://doi.org/10.2337/db10-0866
Adipose Tissue Dysfunction Signals Progression of Hepatic Steatosis Towards Nonalcoholic Steatohepatitis in C57Bl/6 Mice
Caroline Duval; Uwe Thissen; Shohreh Keshtkar; Bertrand Accart; Rinke Stienstra; Mark V. Boekschoten; Tania Roskams; Sander Kersten; Michael Müller
Diabetes September 2010, Vol.59, 3181-3191. doi:https://doi.org/10.2337/db10-0224
High Levels of Serum Prolactin Protect Against Diabetic Retinopathy by Increasing Ocular Vasoinhibins
Edith Arnold; José C. Rivera; Stéphanie Thebault; Daniel Moreno-Páramo; Hugo Quiroz-Mercado; Andrés Quintanar-Stéphano; Nadine Binart; Gonzalo Martínez de la Escalera; Carmen Clapp
Diabetes September 2010, Vol.59, 3192-3197. doi:https://doi.org/10.2337/db10-0873
Complications
Antiatherosclerotic and Renoprotective Effects of Ebselen in the Diabetic Apolipoprotein E/GPx1-Double Knockout Mouse
Phyllis Chew; Derek Y.C. Yuen; Nada Stefanovic; Josefa Pete; Melinda T. Coughlan; Karin A. Jandeleit-Dahm; Merlin C. Thomas; Franklin Rosenfeldt; Mark E. Cooper; Judy B. de Haan
Diabetes September 2010, Vol.59, 3198-3207. doi:https://doi.org/10.2337/db10-0195
Candesartan Attenuates Diabetic Retinal Vascular Pathology by Restoring Glyoxalase-I Function
Antonia G. Miller; Genevieve Tan; Katrina J. Binger; Raelene J. Pickering; Merlin C. Thomas; Ram H. Nagaraj; Mark E. Cooper; Jennifer L. Wilkinson-Berka
Diabetes September 2010, Vol.59, 3208-3215. doi:https://doi.org/10.2337/db10-0552
Cause-Specific Mortality Trends in a Large Population-Based Cohort With Long-Standing Childhood-Onset Type 1 Diabetes
Diabetes August 2010, Vol.59, 3216-3222. doi:https://doi.org/10.2337/db10-0862
Pharmacology and Therapeutics
Apolipoprotein A-I Mimetic Peptides Prevent Atherosclerosis Development and Reduce Plaque Inflammation in a Murine Model of Diabetes
Cecilia Morgantini; Satoshi Imaizumi; Victor Grijalva; Mohamad Navab; Alan M. Fogelman; Srinivasa T. Reddy
Diabetes September 2010, Vol.59, 3223-3228. doi:https://doi.org/10.2337/db10-0844
Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways
Nicole Soranzo; Serena Sanna; Eleanor Wheeler; Christian Gieger; Dörte Radke; Josée Dupuis; Nabila Bouatia-Naji; Claudia Langenberg; Inga Prokopenko; Elliot Stolerman; Manjinder S. Sandhu; Matthew M. Heeney; Joseph M. Devaney; Muredach P. Reilly; Sally L. Ricketts
Diabetes September 2010, Vol.59, 3229-3239. doi:https://doi.org/10.2337/db10-0502
Effects of Salsalate Therapy on Recovery From Vascular Injury in Female Zucker Fatty Rats
Subramanyam N. Murthy; Cyrus V. Desouza; Neal W. Bost; Rose-Claire St. Hilaire; David B. Casey; Adeleke M. Badejo; Jasdeep S. Dhaliwal; Jennifer McGee; Dennis B. McNamara; Philip J. Kadowitz; Vivian A. Fonseca
Diabetes September 2010, Vol.59, 3240-3246. doi:https://doi.org/10.2337/db09-1761
Genetics
Glycemia Determines the Effect of Type 2 Diabetes Risk Genes on Insulin Secretion
Martin Heni; Caroline Ketterer; Claus Thamer; Silke A. Herzberg-Schäfer; Martina Guthoff; Norbert Stefan; Fausto Machicao; Harald Staiger; Andreas Fritsche; Hans-Ulrich Häring
Diabetes August 2010, Vol.59, 3247-3252. doi:https://doi.org/10.2337/db10-0674
Effect of HLA Class I and Class II Alleles on Progression From Autoantibody Positivity to Overt Type 1 Diabetes in Children With Risk-Associated Class II Genotypes
Kati Lipponen; Zsofia Gombos; Minna Kiviniemi; Heli Siljander; Johanna Lempainen; Robert Hermann; Riitta Veijola; Olli Simell; Mikael Knip; Jorma Ilonen
Diabetes August 2010, Vol.59, 3253-3256. doi:https://doi.org/10.2337/db10-0167
