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Issues
Perspectives in Diabetes
A Recurring Problem With the Analysis of Energy Expenditure in Genetic Models Expressing Lean and Obese Phenotypes
Diabetes February 2010, Vol.59, 323-329. doi:https://doi.org/10.2337/db09-1471
Commentaries
Predicting Adult-Onset Autoimmune Diabetes: Clarity From Complexity
Diabetes February 2010, Vol.59, 330-331. doi:https://doi.org/10.2337/db09-1620
A Genome-Wide Association Study of Treated A1C: A Genetic Needle in an Environmental Haystack?
Diabetes February 2010, Vol.59, 332-334. doi:https://doi.org/10.2337/db09-1636
Cytokine-Induced Dicing and Splicing in the β-Cell and the Immune Response in Type 1 Diabetes
Diabetes February 2010, Vol.59, 335-336. doi:https://doi.org/10.2337/db09-1767
Original Article
Metabolism
Divergent Regulation of Energy Expenditure and Hepatic Glucose Production by Insulin Receptor in Agouti-Related Protein and POMC Neurons
Hua V. Lin; Leona Plum; Hiraku Ono; Roger Gutiérrez-Juárez; Marya Shanabrough; Erzsebet Borok; Tamas L. Horvath; Luciano Rossetti; Domenico Accili
Diabetes November 2009, Vol.59, 337-346. doi:https://doi.org/10.2337/db09-1303
Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance
Wan Huang; Anantha Metlakunta; Nikolaos Dedousis; Pili Zhang; Ian Sipula; John J. Dube; Donald K. Scott; Robert M. O'Doherty
Diabetes November 2009, Vol.59, 347-357. doi:https://doi.org/10.2337/db09-0016
Signal Transduction
Cytokines Interleukin-1β and Tumor Necrosis Factor-α Regulate Different Transcriptional and Alternative Splicing Networks in Primary β-Cells
Fernanda Ortis; Najib Naamane; Daisy Flamez; Laurence Ladrière; Fabrice Moore; Daniel A. Cunha; Maikel L. Colli; Thomas Thykjaer; Kasper Thorsen; Torben F. Ørntoft; Decio L. Eizirik
Diabetes November 2009, Vol.59, 358-374. doi:https://doi.org/10.2337/db09-1159
Regulation of MAP Kinase–Directed Mitogenic and Protein Kinase B–Mediated Signaling by Cannabinoid Receptor Type 1 in Skeletal Muscle Cells
Christopher Lipina; Clare Stretton; Simon Hastings; Jonathan S. Hundal; Ken Mackie; Andrew J. Irving; Harinder S. Hundal
Diabetes November 2009, Vol.59, 375-385. doi:https://doi.org/10.2337/db09-0979
Obesity Studies
Differential Effect of Saturated and Unsaturated Free Fatty Acids on the Generation of Monocyte Adhesion and Chemotactic Factors by Adipocytes: Dissociation of Adipocyte Hypertrophy From Inflammation
Chang Yeop Han; Atil Y. Kargi; Mohamed Omer; Christina K. Chan; Martin Wabitsch; Kevin D. O'Brien; Thomas N. Wight; Alan Chait
Diabetes November 2009, Vol.59, 386-396. doi:https://doi.org/10.2337/db09-0925
Prokineticin 2 Is a Hypothalamic Neuropeptide That Potently Inhibits Food Intake
James V. Gardiner; Attia Bataveljic; Neekhil A. Patel; Gavin A. Bewick; Debabrata Roy; Daniel Campbell; Hannah C. Greenwood; Kevin G. Murphy; Saira Hameed; Preeti H. Jethwa; Francis J.P. Ebling; Steven P. Vickers; Sharon Cheetham; Mohammad A. Ghatei; Stephen R. Bloom; Waljit S. Dhillo
Diabetes November 2009, Vol.59, 397-406. doi:https://doi.org/10.2337/db09-1198
Immunology and Transplantation
Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4+CD25+ Regulatory T-Cells of Type 1 Diabetic Subjects
S. Alice Long; Karen Cerosaletti; Paul L. Bollyky; Megan Tatum; Heather Shilling; Sheng Zhang; Zhong-Yin Zhang; Catherine Pihoker; Srinath Sanda; Carla Greenbaum; Jane H. Buckner
Diabetes October 2009, Vol.59, 407-415. doi:https://doi.org/10.2337/db09-0694
GAD Antibody Positivity Predicts Type 2 Diabetes in an Adult Population
Virve M. Lundgren; Bo Isomaa; Valeriya Lyssenko; Esa Laurila; Pasi Korhonen; Leif C. Groop; Tiinamaija Tuomi; for the Botnia Study Group
Diabetes October 2009, Vol.59, 416-422. doi:https://doi.org/10.2337/db09-0747
Invariant Natural Killer T-Cell Control of Type 1 Diabetes: A Dendritic Cell Genetic Decision of a Silver Bullet or Russian Roulette
John P. Driver; Felix Scheuplein; Yi-Guang Chen; Alexandra E. Grier; S. Brian Wilson; David V. Serreze
Diabetes November 2009, Vol.59, 423-432. doi:https://doi.org/10.2337/db09-1116
Antigen-Specific Dependence of Tr1-Cell Therapy in Preclinical Models of Islet Transplant
Nicola Gagliani; Tatiana Jofra; Angela Stabilini; Andrea Valle; Mark Atkinson; Maria-Grazia Roncarolo; Manuela Battaglia
Diabetes November 2009, Vol.59, 433-439. doi:https://doi.org/10.2337/db09-1168
Islet Studies
Lack of TXNIP Protects Against Mitochondria-Mediated Apoptosis but Not Against Fatty Acid–Induced ER Stress–Mediated β-Cell Death
Diabetes October 2009, Vol.59, 440-447. doi:https://doi.org/10.2337/db09-0949
Molecular and Metabolic Evidence for Mitochondrial Defects Associated With β-Cell Dysfunction in a Mouse Model of Type 2 Diabetes
Diabetes November 2009, Vol.59, 448-459. doi:https://doi.org/10.2337/db09-0129
A Point Mutation in Sec61α1 Leads to Diabetes and Hepatosteatosis in Mice
Diabetes November 2009, Vol.59, 460-470. doi:https://doi.org/10.2337/db08-1362
Cellular Production of n-3 PUFAs and Reduction of n-6–to–n-3 Ratios in the Pancreatic β-Cells and Islets Enhance Insulin Secretion and Confer Protection Against Cytokine-Induced Cell Death
Dong Wei; Jie Li; Miaoda Shen; Wei Jia; Nuoqi Chen; Tao Chen; Dongming Su; Haoming Tian; Shusen Zheng; Yifan Dai; Allan Zhao
Diabetes November 2009, Vol.59, 471-478. doi:https://doi.org/10.2337/db09-0284
Pathophysiology
TCF7L2 Variant rs7903146 Affects the Risk of Type 2 Diabetes by Modulating Incretin Action
Dennis T. Villareal; Heather Robertson; Graeme I. Bell; Bruce W. Patterson; Hung Tran; Burton Wice; Kenneth S. Polonsky
Diabetes November 2009, Vol.59, 479-485. doi:https://doi.org/10.2337/db09-1169
Maternal Age at Birth and Childhood Type 1 Diabetes: A Pooled Analysis of 30 Observational Studies
Chris R. Cardwell; Lars C. Stene; Geir Joner; Max K. Bulsara; Ondrej Cinek; Joachim Rosenbauer; Johnny Ludvigsson; Mireia Jané; Jannet Svensson; Michael J. Goldacre; Thomas Waldhoer; Przemysława Jarosz-Chobot; Suely G.A. Gimeno; Lee-Ming Chuang; Roger C. Parslow; Emma J.K. Wadsworth; Amanda Chetwynd; Paolo Pozzilli; Girts Brigis; Brone Urbonaitė; Sandra Šipetić; Edith Schober; Gabriele Devoti; Constantin Ionescu-Tirgoviste; Carine E. de Beaufort; Denka Stoyanov; Karsten Buschard; Chris C. Patterson
Diabetes October 2009, Vol.59, 486-494. doi:https://doi.org/10.2337/db09-1166
Duration of Lactation and Incidence of the Metabolic Syndrome in Women of Reproductive Age According to Gestational Diabetes Mellitus Status: A 20-Year Prospective Study in CARDIA (Coronary Artery Risk Development in Young Adults)
Erica P. Gunderson; David R. Jacobs, Jr; Vicky Chiang; Cora E. Lewis; Juanran Feng; Charles P. Quesenberry, Jr; Stephen Sidney
Diabetes December 2009, Vol.59, 495-504. doi:https://doi.org/10.2337/db09-1197
Complications
Engineered Zinc Finger Protein–Mediated VEGF-A Activation Restores Deficient VEGF-A in Sensory Neurons in Experimental Diabetes
Elizabeth J. Pawson; Beatriz Duran-Jimenez; Richard Surosky; Heather E. Brooke; S. Kaye Spratt; David R. Tomlinson; Natalie J. Gardiner
Diabetes November 2009, Vol.59, 509-518. doi:https://doi.org/10.2337/db08-1526
Ventromedial Hypothalamic Nitric Oxide Production Is Necessary for Hypoglycemia Detection and Counterregulation
Xavier Fioramonti; Nicolas Marsollier; Zhentao Song; Kurt A. Fakira; Reema M. Patel; Stacey Brown; Thibaut Duparc; Arnaldo Pica-Mendez; Nicole M. Sanders; Claude Knauf; Philippe Valet; Rory J. McCrimmon; Annie Beuve; Christophe Magnan; Vanessa H. Routh
Diabetes November 2009, Vol.59, 519-528. doi:https://doi.org/10.2337/db09-0421
Pharmacology and Therapeutics
Human Recombinant ACE2 Reduces the Progression of Diabetic Nephropathy
Gavin Y. Oudit; George C. Liu; JiuChang Zhong; Ratnadeep Basu; Fung L. Chow; Joyce Zhou; Hans Loibner; Evelyne Janzek; Manfred Schuster; Josef M. Penninger; Andrew M. Herzenberg; Zamaneh Kassiri; James W. Scholey
Diabetes November 2009, Vol.59, 529-538. doi:https://doi.org/10.2337/db09-1218
Genetics
A Genome-Wide Association Study Identifies a Novel Major Locus for Glycemic Control in Type 1 Diabetes, as Measured by Both A1C and Glucose
Andrew D. Paterson; Daryl Waggott; Andrew P. Boright; S. Mohsen Hosseini; Enqing Shen; Marie-Pierre Sylvestre; Isidro Wong; Bhupinder Bharaj; Patricia A. Cleary; John M. Lachin; MAGIC (Meta-Analyses of Glucose and Insulin-related traits Consortium); Jennifer E. Below; Dan Nicolae; Nancy J. Cox; Angelo J. Canty; Lei Sun; Shelley B. Bull; the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group
Diabetes October 2009, Vol.59, 539-549. doi:https://doi.org/10.2337/db09-0653
Pathophysiology
IGF-I Bioactivity in an Elderly Population: Relation to Insulin Sensitivity, Insulin Levels, and the Metabolic Syndrome
Michael P. Brugts; Cornelia M. van Duijn; Leo J. Hofland; Jacqueline C. Witteman; Steven W.J. Lamberts; Joseph A.M.J.L. Janssen
Diabetes February 2010, Vol.59, 505-508. doi:https://doi.org/10.2337/db09-0583
