Issues

Topics: autoantibodies , diabetes mellitus, type 1 , insulin , peptides , autoimmunity

Diabetes April 2010, Vol.59, 759-774. doi:https://doi.org/10.2337/db09-1855

Original Article

Metabolism

Mammalian Target of Rapamycin Complex 1 Suppresses Lipolysis, Stimulates Lipogenesis, and Promotes Fat Storage

Partha Chakrabarti; Taylor English; Jun Shi; Cynthia M. Smas; Konstantin V. Kandror

Abstracts

Topics: adipocytes , lipase , lipogenesis , lipolysis , mammals

Diabetes January 2010, Vol.59, 775-781. doi:https://doi.org/10.2337/db09-1602

Insufficiency of Janus Kinase 2–Autonomous Leptin Receptor Signals for Most Physiologic Leptin Actions

Scott Robertson; Ryoko Ishida-Takahashi; Isao Tawara; Jiang Hu; Christa M. Patterson; Justin C. Jones; Rohit N. Kulkarni; Martin G. Myers, Jr

Abstracts

Topics: hypothalamus , leptin , mice , janus kinase

Diabetes January 2010, Vol.59, 782-790. doi:https://doi.org/10.2337/db09-1556

Macrophage Adiponectin Expression Improves Insulin Sensitivity and Protects Against Inflammation and Atherosclerosis

Nanlan Luo; Jian Liu; B. Hong Chung; Qinglin Yang; Richard L. Klein; W. Timothy Garvey; Yuchang Fu

Abstracts

Topics: adiponectin , diet, high-fat , insulin , macrophages , mice

Diabetes April 2010, Vol.59, 791-799. doi:https://doi.org/10.2337/db09-1338

Acute Inhibition of Fatty Acid Import Inhibits GLUT4 Transcription in Adipose Tissue, but Not Skeletal or Cardiac Muscle Tissue, Partly Through Liver X Receptor (LXR) Signaling

Beth A. Griesel; Juston Weems; Robert A. Russell; E. Dale Abel; Kenneth Humphries; Ann Louise Olson

Abstracts

Topics: adipocytes , adipose tissue , fatty acids , insulin , liver x receptors

Diabetes January 2010, Vol.59, 800-807. doi:https://doi.org/10.2337/db09-1542

The Natural Protective Mechanism Against Hyperglycemia in Vascular Endothelial Cells: Roles of the Lipid Peroxidation Product 4-Hydroxydodecadienal and Peroxisome Proliferator–Activated Receptor δ

Yael Riahi; Yoav Sin-Malia; Guy Cohen; Evgenia Alpert; Arie Gruzman; Juergen Eckel; Bart Staels; Michel Guichardant; Shlomo Sasson

Abstracts

Topics: calr gene , endothelial cells , glucose , glut-1 , gw 501516

Diabetes January 2010, Vol.59, 808-818. doi:https://doi.org/10.2337/db09-1207

Compensatory Increases in Nuclear PGC1α Protein Are Primarily Associated With Subsarcolemmal Mitochondrial Adaptations in ZDF Rats

Graham P. Holloway; Brendon J. Gurd; Laelie A. Snook; Jamie Lally; Arend Bonen

Abstracts

Topics: mitochondria , palmitates

Diabetes January 2010, Vol.59, 819-828. doi:https://doi.org/10.2337/db09-1519

SIRT1 mRNA Expression May Be Associated With Energy Expenditure and Insulin Sensitivity

Jarno Rutanen; Nagendra Yaluri; Shalem Modi; Jussi Pihlajamäki; Markku Vänttinen; Paula Itkonen; Sakari Kainulainen; Hiroyasu Yamamoto; Marie Lagouge; David A. Sinclair; Peter Elliott; Christoph Westphal; Johan Auwerx; Markku Laakso

Abstracts

Topics: insulin sensitivity , rna, messenger , adipose tissue

Diabetes January 2010, Vol.59, 829-835. doi:https://doi.org/10.2337/db09-1191

The T-Allele of TCF7L2 rs7903146 Associates With a Reduced Compensation of Insulin Secretion for Insulin Resistance Induced by 9 Days of Bed Rest

Amra C. Alibegovic; Mette P. Sonne; Lise Højbjerre; Torben Hansen; Oluf Pedersen; Gerrit van Hall; Jens J. Holst; Bente Stallknecht; Flemming Dela; Allan Vaag

Abstracts

Topics: alleles , bed rest , chief complaint , insulin , insulin secretion

Diabetes January 2010, Vol.59, 836-843. doi:https://doi.org/10.2337/db09-0918

Signal Transduction

High Glucose–Induced Oxidative Stress Increases Transient Receptor Potential Channel Expression in Human Monocytes

Tilo Wuensch; Florian Thilo; Katharina Krueger; Alexandra Scholze; Michael Ristow; Martin Tepel

Abstracts

Topics: glucose , monocytes , oxidative stress , trpc6 cation channel , rna, messenger

Diabetes January 2010, Vol.59, 844-849. doi:https://doi.org/10.2337/db09-1100

The Protective Role of Nrf2 in Streptozotocin-Induced Diabetic Nephropathy

Tao Jiang; Zheping Huang; Yifeng Lin; Zhigang Zhang; Deyu Fang; Donna D. Zhang

Abstracts

Topics: diabetic nephropathy , glucose , kidney , kidney glomerulus , mice

Diabetes January 2010, Vol.59, 850-860. doi:https://doi.org/10.2337/db09-1342

Inducible Nitric Oxide Synthase Induction Underlies Lipid-Induced Hepatic Insulin Resistance in Mice: Potential Role of Tyrosine Nitration of Insulin Signaling Proteins

Alexandre Charbonneau; André Marette

Abstracts

Topics: insulin , lipids , mice , nitric oxide synthase , proto-oncogene proteins c-akt

Diabetes January 2010, Vol.59, 861-871. doi:https://doi.org/10.2337/db09-1238

Obesity Studies

Lipocalin-2 Deficiency Attenuates Insulin Resistance Associated With Aging and Obesity

Ivy K.M. Law; Aimin Xu; Karen S.L. Lam; Thorsten Berger; Tak W. Mak; Paul M. Vanhoutte; Jacky T.C. Liu; Gary Sweeney; Mingyan Zhou; Bo Yang; Yu Wang

Abstracts

Topics: insulin , lipocalin-2 protein , mice , obesity , tumor necrosis factors

Diabetes January 2010, Vol.59, 872-882. doi:https://doi.org/10.2337/db09-1541

Deficiency of Phosphoinositide 3-Kinase Enhancer Protects Mice From Diet-Induced Obesity and Insulin Resistance

Chi Bun Chan; Xia Liu; Dae Young Jung; John Y. Jun; Hongbo R. Luo; Jason K. Kim; Keqiang Ye

Abstracts

Topics: diet , insulin , lipids , mice , obesity

Diabetes January 2010, Vol.59, 883-893. doi:https://doi.org/10.2337/db09-1404

Functional Role of Suppressor of Cytokine Signaling 3 Upregulation in Hypothalamic Leptin Resistance and Long-Term Energy Homeostasis

Alison S. Reed; Elizabeth K. Unger; Louise E. Olofsson; Merisa L. Piper; Martin G. Myers, Jr; Allison W. Xu

Abstracts

Topics: leptin , neurons , obesity , pro-opiomelanocortin , suppressor of cytokine signaling 3 protein

Diabetes January 2010, Vol.59, 894-906. doi:https://doi.org/10.2337/db09-1024

Peptide Designed to Elicit Apoptosis in Adipose Tissue Endothelium Reduces Food Intake and Body Weight

Dong-Hoon Kim; Stephen C. Woods; Randy J. Seeley

Abstracts

Topics: peptides , mice , eating , leptin

Diabetes January 2010, Vol.59, 907-915. doi:https://doi.org/10.2337/db09-1141

C-C Chemokine Receptor 2 (CCR2) Regulates the Hepatic Recruitment of Myeloid Cells That Promote Obesity-Induced Hepatic Steatosis

Amrom E. Obstfeld; Eiji Sugaru; Marie Thearle; Anne-Marie Francisco; Constance Gayet; Henry N. Ginsberg; Eleanore V. Ables; Anthony W. Ferrante, Jr

Abstracts

Topics: fatty liver , liver , mice , monocyte chemoattractant protein-1 , myeloid cells

Diabetes January 2010, Vol.59, 916-925. doi:https://doi.org/10.2337/db09-1403

CB1 Antagonism Exerts Specific Molecular Effects on Visceral and Subcutaneous Fat and Reverses Liver Steatosis in Diet-Induced Obese Mice

Tony Jourdan; Louiza Djaouti; Laurent Demizieux; Joseph Gresti; Bruno Vergès; Pascal Degrace

Abstracts

Topics: adipose tissue , antagonists , diet , fat, subcutaneous , fatty liver

Diabetes January 2010, Vol.59, 926-934. doi:https://doi.org/10.2337/db09-1482

Neutralization of Osteopontin Inhibits Obesity-Induced Inflammation and Insulin Resistance

Florian W. Kiefer; Maximilian Zeyda; Karina Gollinger; Birgit Pfau; Angelika Neuhofer; Thomas Weichhart; Marcus D. Säemann; René Geyeregger; Michaela Schlederer; Lukas Kenner; Thomas M. Stulnig

Abstracts

Topics: antibodies , inflammation , insulin resistance , neutralization , obesity

Diabetes January 2010, Vol.59, 935-946. doi:https://doi.org/10.2337/db09-0404

Immunology and Transplantation

Recurrence of Type 1 Diabetes After Simultaneous Pancreas-Kidney Transplantation, Despite Immunosuppression, Is Associated With Autoantibodies and Pathogenic Autoreactive CD4 T-Cells

Abstracts

Topics: autoantibodies , diabetes mellitus, type 1 , generalized anxiety disorder , therapeutic immunosuppression , t-lymphocytes

Diabetes January 2010, Vol.59, 947-957. doi:https://doi.org/10.2337/db09-0498

Short-Term Administrations of a Combination of Anti–LFA-1 and Anti-CD154 Monoclonal Antibodies Induce Tolerance to Neonatal Porcine Islet Xenografts in Mice

Hossein Arefanian; Eric B. Tredget; Ray V. Rajotte; Ron G. Gill; Gregory S. Korbutt; Gina R. Rayat

Abstracts

Topics: cd40 ligand , lymphocyte function-associated antigen-1 , mice , monoclonal antibodies , national provider identifier

Diabetes January 2010, Vol.59, 958-966. doi:https://doi.org/10.2337/db09-0413

Islet Studies

Protein Farnesylation–Dependent Raf/Extracellular Signal–Related Kinase Signaling Links to Cytoskeletal Remodeling to Facilitate Glucose-Induced Insulin Secretion in Pancreatic β-Cells

Anjaneyulu Kowluru; Rajakrishnan Veluthakal; Christopher J. Rhodes; Vasudeva Kamath; Ismail Syed; Brandon J. Koch

Abstracts

Topics: glucose , insulin secretion , rna, small interfering , pancreas , proto-oncogene proteins c-raf

Diabetes January 2010, Vol.59, 967-977. doi:https://doi.org/10.2337/db09-1334

Involvement of MicroRNAs in the Cytotoxic Effects Exerted by Proinflammatory Cytokines on Pancreatic β-Cells

Elodie Roggli; Aurore Britan; Sonia Gattesco; Nathalie Lin-Marq; Amar Abderrahmani; Paolo Meda; Romano Regazzi

Abstracts

Topics: cytokine , micrornas , insulin

Diabetes January 2010, Vol.59, 978-986. doi:https://doi.org/10.2337/db09-0881

Cyclin D2 Is Essential for the Compensatory β-Cell Hyperplastic Response to Insulin Resistance in Rodents

Senta Georgia; Charlotte Hinault; Dan Kawamori; Jiang Hu; John Meyer; Murtaza Kanji; Anil Bhushan; Rohit N. Kulkarni

Abstracts

Topics: cyclins , hyperplasia , insulin , insulin resistance , mice

Diabetes January 2010, Vol.59, 987-996. doi:https://doi.org/10.2337/db09-0838

Pathophysiology

Increased CYP2J3 Expression Reduces Insulin Resistance in Fructose-Treated Rats and db/db Mice

Xizhen Xu; Chun Xia Zhao; Luyun Wang; Ling Tu; Xiaosai Fang; Changlong Zheng; Matthew L. Edin; Darryl C. Zeldin; Dao Wen Wang

Abstracts

Topics: fructose , genes , insulin resistance , mice , rats

Diabetes January 2010, Vol.59, 997-1005. doi:https://doi.org/10.2337/db09-1241

Downregulation of the Longevity-Associated Protein Sirtuin 1 in Insulin Resistance and Metabolic Syndrome: Potential Biochemical Mechanisms

Saula Vigili de Kreutzenberg; Giulio Ceolotto; Italia Papparella; Alessia Bortoluzzi; Andrea Semplicini; Chiara Dalla Man; Claudio Cobelli; Gian Paolo Fadini; Angelo Avogaro

Abstracts

Topics: glucose , insulin resistance , metabolic syndrome x , palmitic acid , thp-1 cells

Diabetes January 2010, Vol.59, 1006-1015. doi:https://doi.org/10.2337/db09-1187

Unacylated Ghrelin Rescues Endothelial Progenitor Cell Function in Individuals With Type 2 Diabetes

Gabriele Togliatto; Antonella Trombetta; Patrizia Dentelli; Alessandra Baragli; Arturo Rosso; Riccarda Granata; Dario Ghigo; Luigi Pegoraro; Ezio Ghigo; Maria Felice Brizzi

Abstracts

Topics: diabetes mellitus, type 2 , ghrelin , mice , nitric oxide synthase , endothelial progenitor cells

Diabetes January 2010, Vol.59, 1016-1025. doi:https://doi.org/10.2337/db09-0858

Complications

Inhibition of Monocyte Adhesion to Endothelial Cells and Attenuation of Atherosclerotic Lesion by a Glucagon-like Peptide-1 Receptor Agonist, Exendin-4

Masayuki Arakawa; Tomoya Mita; Kosuke Azuma; Chie Ebato; Hiromasa Goto; Takashi Nomiyama; Yoshio Fujitani; Takahisa Hirose; Ryuzo Kawamori; Hirotaka Watada

Abstracts

Topics: adhesions , exenatide , macrophages , mice , monocytes

Diabetes January 2010, Vol.59, 1030-1037. doi:https://doi.org/10.2337/db09-1694

Increased Glycation and Oxidative Damage to Apolipoprotein B100 of LDL Cholesterol in Patients With Type 2 Diabetes and Effect of Metformin

Naila Rabbani; Madhu Varma Chittari; Charles W. Bodmer; Daniel Zehnder; Antonio Ceriello; Paul J. Thornalley

Abstracts

Topics: apolipoprotein b-100 , diabetes mellitus, type 2 , low-density lipoproteins , metformin , glycation

Diabetes January 2010, Vol.59, 1038-1045. doi:https://doi.org/10.2337/db09-1455

Cannabinoid Receptor 1 Blockade Ameliorates Albuminuria in Experimental Diabetic Nephropathy

Federica Barutta; Alessandro Corbelli; Raffaella Mastrocola; Roberto Gambino; Vincenzo Di Marzo; Silvia Pinach; Maria Pia Rastaldi; Paolo Cavallo Perin; Gabriella Gruden

Abstracts

Topics: albuminuria , am 251 , kidney glomerulus , mice , podocytes

Diabetes January 2010, Vol.59, 1046-1054. doi:https://doi.org/10.2337/db09-1336

Recurrent Moderate Hypoglycemia Ameliorates Brain Damage and Cognitive Dysfunction Induced by Severe Hypoglycemia

Erwin C. Puente; Julie Silverstein; Adam J. Bree; Daniel R. Musikantow; David F. Wozniak; Susan Maloney; Dorit Daphna-Iken; Simon J. Fisher

Abstracts

Topics: brain injuries , hypoglycemia , hypoglycemic agents , rats

Diabetes January 2010, Vol.59, 1055-1062. doi:https://doi.org/10.2337/db09-1495

Genetic Deletion or Pharmacological Inhibition of Dipeptidyl Peptidase-4 Improves Cardiovascular Outcomes After Myocardial Infarction in Mice

Meghan Sauvé; Kiwon Ban; M. Abdul Momen; Yu-Qing Zhou; R. Mark Henkelman; Mansoor Husain; Daniel J. Drucker

Abstracts

Topics: heart , metformin , mice , sitagliptin , dipeptidyl-peptidase iv

Diabetes January 2010, Vol.59, 1063-1073. doi:https://doi.org/10.2337/db09-0955

Effects of Antecedent GABA_A Activation With Alprazolam on Counterregulatory Responses to Hypoglycemia in Healthy Humans

Maka S. Hedrington; Stephnie Farmerie; Andrew C. Ertl; Zhihui Wang; Donna B. Tate; Stephen N. Davis

Abstracts

Topics: alprazolam , glucose , hypoglycemia , blood glucose normal , insulin

Diabetes January 2010, Vol.59, 1074-1081. doi:https://doi.org/10.2337/db09-1520

Mitochondrial Respiratory Chain Dysfunction in Dorsal Root Ganglia of Streptozotocin-Induced Diabetic Rats and Its Correction by Insulin Treatment

Subir K. Roy Chowdhury; Elena Zherebitskaya; Darrell R. Smith; Eli Akude; Sharmila Chattopadhyay; Corinne G. Jolivalt; Nigel A. Calcutt; Paul Fernyhough

Abstracts

Topics: ganglia, spinal , insulin , mitochondria , rats , streptozocin

Diabetes January 2010, Vol.59, 1082-1091. doi:https://doi.org/10.2337/db09-1299

Pharmacology and Therapeutics

The Prostacyclin Analog Beraprost Sodium Ameliorates Characteristics of Metabolic Syndrome in Obese Zucker (Fatty) Rats

Nahoko Sato; Masayuki Kaneko; Mitsutaka Tamura; Hajimu Kurumatani

Abstracts

Topics: obesity , rats , rats, zucker , insulin resistance , epoprostenol

Diabetes January 2010, Vol.59, 1092-1100. doi:https://doi.org/10.2337/db09-1432

Euglycemic Infusion of Insulin Detemir Compared With Human Insulin Appears to Increase Direct Current Brain Potential Response and Reduces Food Intake While Inducing Similar Systemic Effects

Manfred Hallschmid; Kamila Jauch-Chara; Oliver Korn; Matthias Mölle; Björn Rasch; Jan Born; Bernd Schultes; Werner Kern

Abstracts

Topics: eating , infusion procedures , insulin , glucose , insulin administration

Diabetes January 2010, Vol.59, 1101-1107. doi:https://doi.org/10.2337/db09-1493

Brief Report

Pathophysiology

Serum Soluble Glycoprotein 130 Concentration Is Inversely Related to Insulin Sensitivity in Women With Polycystic Ovary Syndrome

Agnieszka Nikolajuk; Irina Kowalska; Monika Karczewska-Kupczewska; Agnieszka Adamska; Elzbieta Otziomek; Slawomir Wolczynski; Ida Kinalska; Maria Gorska; Marek Straczkowski

Abstracts

Topics: insulin , insulin sensitivity , obesity , polycystic ovary syndrome , interleukin-6

Diabetes January 2010, Vol.59, 1026-1029. doi:https://doi.org/10.2337/db09-1316

Genetics

Impact of rs361072 in the Phosphoinositide 3-Kinase p110β Gene on Whole-Body Glucose Metabolism and Subunit Protein Expression in Skeletal Muscle

Rasmus Ribel-Madsen; Pernille Poulsen; Johan Holmkvist; Brynjulf Mortensen; Niels Grarup; Martin Friedrichsen; Torben Jørgensen; Torsten Lauritzen; Jørgen F.P. Wojtaszewski; Oluf Pedersen; Torben Hansen; Allan Vaag

Abstracts

Topics: alleles , diabetes mellitus, type 2 , genes , glucose , glucose metabolism

Diabetes January 2010, Vol.59, 1108-1112. doi:https://doi.org/10.2337/db09-1359

Errata

Extract

Topics: collagen , diabetic nephropathy , immunohistochemistry , inflammation , kidney

Diabetes April 2010, Vol.59, 1113-1114. doi:https://doi.org/10.2337/db10-er04

Errata

Extract

Topics: burns , diabetic nephropathy , glycosylation end products, advanced

Diabetes April 2010, Vol.59, 1113. doi:https://doi.org/10.2337/db10-er04a

Online Letters to the Editor

Comment on: Padmavathi et al. (2010) Chronic Maternal Dietary Chromium Restriction Modulates Visceral Adiposity: Probable Underlying Mechanisms. Diabetes;59:98–104

John B. Vincent; Jane F. Rasco

Extract

Topics: chromium , diet , obesity

Diabetes April 2010, Vol.59, e2. doi:https://doi.org/10.2337/db10-0043

Response to Comment on: Padmavathi et al. (2010) Chronic Maternal Dietary Chromium Restriction Modulates Visceral Adiposity: Probable Underlying Mechanisms. Diabetes;59:98–104

Inagadapa J.N. Padmavathi; Venu Lagishetty; Manchala Raghunath

Extract