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Banting Lecture
Banting Lecture 2009: An Unfinished Journey: Molecular Pathogenesis to Prevention of Type 1A Diabetes
Diabetes April 2010, Vol.59, 759-774. doi:https://doi.org/10.2337/db09-1855
Original Article
Metabolism
Mammalian Target of Rapamycin Complex 1 Suppresses Lipolysis, Stimulates Lipogenesis, and Promotes Fat Storage
Diabetes January 2010, Vol.59, 775-781. doi:https://doi.org/10.2337/db09-1602
Insufficiency of Janus Kinase 2–Autonomous Leptin Receptor Signals for Most Physiologic Leptin Actions
Scott Robertson; Ryoko Ishida-Takahashi; Isao Tawara; Jiang Hu; Christa M. Patterson; Justin C. Jones; Rohit N. Kulkarni; Martin G. Myers, Jr
Diabetes January 2010, Vol.59, 782-790. doi:https://doi.org/10.2337/db09-1556
Macrophage Adiponectin Expression Improves Insulin Sensitivity and Protects Against Inflammation and Atherosclerosis
Diabetes April 2010, Vol.59, 791-799. doi:https://doi.org/10.2337/db09-1338
The Natural Protective Mechanism Against Hyperglycemia in Vascular Endothelial Cells: Roles of the Lipid Peroxidation Product 4-Hydroxydodecadienal and Peroxisome Proliferator–Activated Receptor δ
Yael Riahi; Yoav Sin-Malia; Guy Cohen; Evgenia Alpert; Arie Gruzman; Juergen Eckel; Bart Staels; Michel Guichardant; Shlomo Sasson
Diabetes January 2010, Vol.59, 808-818. doi:https://doi.org/10.2337/db09-1207
Compensatory Increases in Nuclear PGC1α Protein Are Primarily Associated With Subsarcolemmal Mitochondrial Adaptations in ZDF Rats
Diabetes January 2010, Vol.59, 819-828. doi:https://doi.org/10.2337/db09-1519
SIRT1 mRNA Expression May Be Associated With Energy Expenditure and Insulin Sensitivity
Jarno Rutanen; Nagendra Yaluri; Shalem Modi; Jussi Pihlajamäki; Markku Vänttinen; Paula Itkonen; Sakari Kainulainen; Hiroyasu Yamamoto; Marie Lagouge; David A. Sinclair; Peter Elliott; Christoph Westphal; Johan Auwerx; Markku Laakso
Diabetes January 2010, Vol.59, 829-835. doi:https://doi.org/10.2337/db09-1191
The T-Allele of TCF7L2 rs7903146 Associates With a Reduced Compensation of Insulin Secretion for Insulin Resistance Induced by 9 Days of Bed Rest
Amra C. Alibegovic; Mette P. Sonne; Lise Højbjerre; Torben Hansen; Oluf Pedersen; Gerrit van Hall; Jens J. Holst; Bente Stallknecht; Flemming Dela; Allan Vaag
Diabetes January 2010, Vol.59, 836-843. doi:https://doi.org/10.2337/db09-0918
Signal Transduction
High Glucose–Induced Oxidative Stress Increases Transient Receptor Potential Channel Expression in Human Monocytes
Diabetes January 2010, Vol.59, 844-849. doi:https://doi.org/10.2337/db09-1100
The Protective Role of Nrf2 in Streptozotocin-Induced Diabetic Nephropathy
Diabetes January 2010, Vol.59, 850-860. doi:https://doi.org/10.2337/db09-1342
Obesity Studies
Lipocalin-2 Deficiency Attenuates Insulin Resistance Associated With Aging and Obesity
Ivy K.M. Law; Aimin Xu; Karen S.L. Lam; Thorsten Berger; Tak W. Mak; Paul M. Vanhoutte; Jacky T.C. Liu; Gary Sweeney; Mingyan Zhou; Bo Yang; Yu Wang
Diabetes January 2010, Vol.59, 872-882. doi:https://doi.org/10.2337/db09-1541
Deficiency of Phosphoinositide 3-Kinase Enhancer Protects Mice From Diet-Induced Obesity and Insulin Resistance
Diabetes January 2010, Vol.59, 883-893. doi:https://doi.org/10.2337/db09-1404
Functional Role of Suppressor of Cytokine Signaling 3 Upregulation in Hypothalamic Leptin Resistance and Long-Term Energy Homeostasis
Alison S. Reed; Elizabeth K. Unger; Louise E. Olofsson; Merisa L. Piper; Martin G. Myers, Jr; Allison W. Xu
Diabetes January 2010, Vol.59, 894-906. doi:https://doi.org/10.2337/db09-1024
Peptide Designed to Elicit Apoptosis in Adipose Tissue Endothelium Reduces Food Intake and Body Weight
Diabetes January 2010, Vol.59, 907-915. doi:https://doi.org/10.2337/db09-1141
C-C Chemokine Receptor 2 (CCR2) Regulates the Hepatic Recruitment of Myeloid Cells That Promote Obesity-Induced Hepatic Steatosis
Amrom E. Obstfeld; Eiji Sugaru; Marie Thearle; Anne-Marie Francisco; Constance Gayet; Henry N. Ginsberg; Eleanore V. Ables; Anthony W. Ferrante, Jr
Diabetes January 2010, Vol.59, 916-925. doi:https://doi.org/10.2337/db09-1403
CB1 Antagonism Exerts Specific Molecular Effects on Visceral and Subcutaneous Fat and Reverses Liver Steatosis in Diet-Induced Obese Mice
Diabetes January 2010, Vol.59, 926-934. doi:https://doi.org/10.2337/db09-1482
Neutralization of Osteopontin Inhibits Obesity-Induced Inflammation and Insulin Resistance
Florian W. Kiefer; Maximilian Zeyda; Karina Gollinger; Birgit Pfau; Angelika Neuhofer; Thomas Weichhart; Marcus D. Säemann; René Geyeregger; Michaela Schlederer; Lukas Kenner; Thomas M. Stulnig
Diabetes January 2010, Vol.59, 935-946. doi:https://doi.org/10.2337/db09-0404
Immunology and Transplantation
Recurrence of Type 1 Diabetes After Simultaneous Pancreas-Kidney Transplantation, Despite Immunosuppression, Is Associated With Autoantibodies and Pathogenic Autoreactive CD4 T-Cells
Francesco Vendrame; Antonello Pileggi; Elsa Laughlin; Gloria Allende; Ainhoa Martin-Pagola; R. Damaris Molano; Stavros Diamantopoulos; Nathan Standifer; Kelly Geubtner; Ben A. Falk; Hirohito Ichii; Hidenori Takahashi; Isaac Snowhite; Zhibin Chen; Armando Mendez; Linda Chen; Junichiro Sageshima; Phillip Ruiz; Gaetano Ciancio; Camillo Ricordi; Helena Reijonen; Gerald T. Nepom; George W. Burke, III; Alberto Pugliese
Diabetes January 2010, Vol.59, 947-957. doi:https://doi.org/10.2337/db09-0498
Islet Studies
Protein Farnesylation–Dependent Raf/Extracellular Signal–Related Kinase Signaling Links to Cytoskeletal Remodeling to Facilitate Glucose-Induced Insulin Secretion in Pancreatic β-Cells
Anjaneyulu Kowluru; Rajakrishnan Veluthakal; Christopher J. Rhodes; Vasudeva Kamath; Ismail Syed; Brandon J. Koch
Diabetes January 2010, Vol.59, 967-977. doi:https://doi.org/10.2337/db09-1334
Cyclin D2 Is Essential for the Compensatory β-Cell Hyperplastic Response to Insulin Resistance in Rodents
Senta Georgia; Charlotte Hinault; Dan Kawamori; Jiang Hu; John Meyer; Murtaza Kanji; Anil Bhushan; Rohit N. Kulkarni
Diabetes January 2010, Vol.59, 987-996. doi:https://doi.org/10.2337/db09-0838
Pathophysiology
Increased CYP2J3 Expression Reduces Insulin Resistance in Fructose-Treated Rats and db/db Mice
Xizhen Xu; Chun Xia Zhao; Luyun Wang; Ling Tu; Xiaosai Fang; Changlong Zheng; Matthew L. Edin; Darryl C. Zeldin; Dao Wen Wang
Diabetes January 2010, Vol.59, 997-1005. doi:https://doi.org/10.2337/db09-1241
Downregulation of the Longevity-Associated Protein Sirtuin 1 in Insulin Resistance and Metabolic Syndrome: Potential Biochemical Mechanisms
Saula Vigili de Kreutzenberg; Giulio Ceolotto; Italia Papparella; Alessia Bortoluzzi; Andrea Semplicini; Chiara Dalla Man; Claudio Cobelli; Gian Paolo Fadini; Angelo Avogaro
Diabetes January 2010, Vol.59, 1006-1015. doi:https://doi.org/10.2337/db09-1187
Unacylated Ghrelin Rescues Endothelial Progenitor Cell Function in Individuals With Type 2 Diabetes
Gabriele Togliatto; Antonella Trombetta; Patrizia Dentelli; Alessandra Baragli; Arturo Rosso; Riccarda Granata; Dario Ghigo; Luigi Pegoraro; Ezio Ghigo; Maria Felice Brizzi
Diabetes January 2010, Vol.59, 1016-1025. doi:https://doi.org/10.2337/db09-0858
Complications
Inhibition of Monocyte Adhesion to Endothelial Cells and Attenuation of Atherosclerotic Lesion by a Glucagon-like Peptide-1 Receptor Agonist, Exendin-4
Masayuki Arakawa; Tomoya Mita; Kosuke Azuma; Chie Ebato; Hiromasa Goto; Takashi Nomiyama; Yoshio Fujitani; Takahisa Hirose; Ryuzo Kawamori; Hirotaka Watada
Diabetes January 2010, Vol.59, 1030-1037. doi:https://doi.org/10.2337/db09-1694
Increased Glycation and Oxidative Damage to Apolipoprotein B100 of LDL Cholesterol in Patients With Type 2 Diabetes and Effect of Metformin
Naila Rabbani; Madhu Varma Chittari; Charles W. Bodmer; Daniel Zehnder; Antonio Ceriello; Paul J. Thornalley
Diabetes January 2010, Vol.59, 1038-1045. doi:https://doi.org/10.2337/db09-1455
Cannabinoid Receptor 1 Blockade Ameliorates Albuminuria in Experimental Diabetic Nephropathy
Federica Barutta; Alessandro Corbelli; Raffaella Mastrocola; Roberto Gambino; Vincenzo Di Marzo; Silvia Pinach; Maria Pia Rastaldi; Paolo Cavallo Perin; Gabriella Gruden
Diabetes January 2010, Vol.59, 1046-1054. doi:https://doi.org/10.2337/db09-1336
Recurrent Moderate Hypoglycemia Ameliorates Brain Damage and Cognitive Dysfunction Induced by Severe Hypoglycemia
Erwin C. Puente; Julie Silverstein; Adam J. Bree; Daniel R. Musikantow; David F. Wozniak; Susan Maloney; Dorit Daphna-Iken; Simon J. Fisher
Diabetes January 2010, Vol.59, 1055-1062. doi:https://doi.org/10.2337/db09-1495
Genetic Deletion or Pharmacological Inhibition of Dipeptidyl Peptidase-4 Improves Cardiovascular Outcomes After Myocardial Infarction in Mice
Meghan Sauvé; Kiwon Ban; M. Abdul Momen; Yu-Qing Zhou; R. Mark Henkelman; Mansoor Husain; Daniel J. Drucker
Diabetes January 2010, Vol.59, 1063-1073. doi:https://doi.org/10.2337/db09-0955
Effects of Antecedent GABAA Activation With Alprazolam on Counterregulatory Responses to Hypoglycemia in Healthy Humans
Diabetes January 2010, Vol.59, 1074-1081. doi:https://doi.org/10.2337/db09-1520
Mitochondrial Respiratory Chain Dysfunction in Dorsal Root Ganglia of Streptozotocin-Induced Diabetic Rats and Its Correction by Insulin Treatment
Subir K. Roy Chowdhury; Elena Zherebitskaya; Darrell R. Smith; Eli Akude; Sharmila Chattopadhyay; Corinne G. Jolivalt; Nigel A. Calcutt; Paul Fernyhough
Diabetes January 2010, Vol.59, 1082-1091. doi:https://doi.org/10.2337/db09-1299
Pharmacology and Therapeutics
The Prostacyclin Analog Beraprost Sodium Ameliorates Characteristics of Metabolic Syndrome in Obese Zucker (Fatty) Rats
Diabetes January 2010, Vol.59, 1092-1100. doi:https://doi.org/10.2337/db09-1432
Euglycemic Infusion of Insulin Detemir Compared With Human Insulin Appears to Increase Direct Current Brain Potential Response and Reduces Food Intake While Inducing Similar Systemic Effects
Manfred Hallschmid; Kamila Jauch-Chara; Oliver Korn; Matthias Mölle; Björn Rasch; Jan Born; Bernd Schultes; Werner Kern
Diabetes January 2010, Vol.59, 1101-1107. doi:https://doi.org/10.2337/db09-1493
Brief Report
Pathophysiology
Serum Soluble Glycoprotein 130 Concentration Is Inversely Related to Insulin Sensitivity in Women With Polycystic Ovary Syndrome
Agnieszka Nikolajuk; Irina Kowalska; Monika Karczewska-Kupczewska; Agnieszka Adamska; Elzbieta Otziomek; Slawomir Wolczynski; Ida Kinalska; Maria Gorska; Marek Straczkowski
Diabetes January 2010, Vol.59, 1026-1029. doi:https://doi.org/10.2337/db09-1316
Genetics
Impact of rs361072 in the Phosphoinositide 3-Kinase p110β Gene on Whole-Body Glucose Metabolism and Subunit Protein Expression in Skeletal Muscle
Rasmus Ribel-Madsen; Pernille Poulsen; Johan Holmkvist; Brynjulf Mortensen; Niels Grarup; Martin Friedrichsen; Torben Jørgensen; Torsten Lauritzen; Jørgen F.P. Wojtaszewski; Oluf Pedersen; Torben Hansen; Allan Vaag
Diabetes January 2010, Vol.59, 1108-1112. doi:https://doi.org/10.2337/db09-1359
