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Issues
Perspectives in Diabetes
Is the Diminished Incretin Effect in Type 2 Diabetes Just an Epi-Phenomenon of Impaired β-Cell Function?
Diabetes May 2010, Vol.59, 1117-1125. doi:https://doi.org/10.2337/db09-1899
Commentaries
Enterovirus Infection of Human β-Cells Activates Dendritic Cells and Triggers Innate Antiviral Responses: Are Enteroviruses Convicted Now?
Diabetes May 2010, Vol.59, 1126-1128. doi:https://doi.org/10.2337/db10-0057
Diabetes, Insulin Use, and Cancer Risk: Are Observational Studies Part of the Solution–or Part of the Problem?
Diabetes May 2010, Vol.59, 1129-1131. doi:https://doi.org/10.2337/db10-0334
Original Article
Metabolism
Downregulation of Adipose Glutathione S-Transferase A4 Leads to Increased Protein Carbonylation, Oxidative Stress, and Mitochondrial Dysfunction
Jessica M. Curtis; Paul A. Grimsrud; Wendy S. Wright; Xin Xu; Rocio E. Foncea; David W. Graham; Jonathan R. Brestoff; Brian M. Wiczer; Olga Ilkayeva; Katherine Cianflone; Deborah E. Muoio; Edgar A. Arriaga; David A. Bernlohr
Diabetes February 2010, Vol.59, 1132-1142. doi:https://doi.org/10.2337/db09-1105
Vasoactive Intestinal Peptide–Null Mice Demonstrate Enhanced Sweet Taste Preference, Dysglycemia, and Reduced Taste Bud Leptin Receptor Expression
Bronwen Martin; Yu-Kyong Shin; Caitlin M. White; Sunggoan Ji; Wook Kim; Olga D. Carlson; Joshua K. Napora; Wayne Chadwick; Megan Chapter; James A. Waschek; Mark P. Mattson; Stuart Maudsley; Josephine M. Egan
Diabetes February 2010, Vol.59, 1143-1152. doi:https://doi.org/10.2337/db09-0807
Lipoprotein Particle Size and Concentration by Nuclear Magnetic Resonance and Incident Type 2 Diabetes in Women
Diabetes February 2010, Vol.59, 1153-1160. doi:https://doi.org/10.2337/db09-1114
Signal Transduction
Full-Length Adiponectin Attenuates Insulin Signaling and Inhibits Insulin-Stimulated Amino Acid Transport in Human Primary Trophoblast Cells
Diabetes February 2010, Vol.59, 1161-1170. doi:https://doi.org/10.2337/db09-0824
Obesity Studies
Dynamic, M2-Like Remodeling Phenotypes of CD11c+ Adipose Tissue Macrophages During High-Fat Diet–Induced Obesity in Mice
Diabetes February 2010, Vol.59, 1171-1181. doi:https://doi.org/10.2337/db09-1402
Islet Studies
Phagocytosis of Enterovirus-Infected Pancreatic β-Cells Triggers Innate Immune Responses in Human Dendritic Cells
Barbara M. Schulte; Matthijs Kramer; Marleen Ansems; Kjerstin H.W. Lanke; Neeltje van Doremalen; Jon D. Piganelli; Rita Bottino; Massimo Trucco; Jochem M.D. Galama; Gosse J. Adema; Frank J.M. van Kuppeveld
Diabetes January 2010, Vol.59, 1182-1191. doi:https://doi.org/10.2337/db09-1071
Progression of Diet-Induced Diabetes in C57BL6J Mice Involves Functional Dissociation of Ca2+ Channels From Secretory Vesicles
Stephan C. Collins; Michael B. Hoppa; Jonathan N. Walker; Stefan Amisten; Fernando Abdulkader; Martin Bengtsson; Jane Fearnside; Reshma Ramracheya; Ayo A. Toye; Quan Zhang; Anne Clark; Dominique Gauguier; Patrik Rorsman
Diabetes February 2010, Vol.59, 1192-1201. doi:https://doi.org/10.2337/db09-0791
Unique Arrangement of α- and β-Cells in Human Islets of Langerhans
Domenico Bosco; Mathieu Armanet; Philippe Morel; Nadja Niclauss; Antonino Sgroi; Yannick D. Muller; Laurianne Giovannoni; Géraldine Parnaud; Thierry Berney
Diabetes May 2010, Vol.59, 1202-1210. doi:https://doi.org/10.2337/db09-1177
Hedgehog Signaling in Pancreas Epithelium Regulates Embryonic Organ Formation and Adult β-Cell Function
Diabetes February 2010, Vol.59, 1211-1221. doi:https://doi.org/10.2337/db09-0914
Pathophysiology
Accelerated Increase in Serum Interleukin-1 Receptor Antagonist Starts 6 Years Before Diagnosis of Type 2 Diabetes: Whitehall II Prospective Cohort Study
Maren Carstensen; Christian Herder; Mika Kivimäki; Markus Jokela; Michael Roden; Martin J. Shipley; Daniel R. Witte; Eric J. Brunner; Adam G. Tabák
Diabetes February 2010, Vol.59, 1222-1227. doi:https://doi.org/10.2337/db09-1199
Glucose Intolerance and Reduced Proliferation of Pancreatic β-Cells in Transgenic Pigs With Impaired Glucose-Dependent Insulinotropic Polypeptide Function
Simone Renner; Christiane Fehlings; Nadja Herbach; Andreas Hofmann; Dagmar C. von Waldthausen; Barbara Kessler; Karin Ulrichs; Irina Chodnevskaja; Vasiliy Moskalenko; Werner Amselgruber; Burkhard Göke; Alexander Pfeifer; Rüdiger Wanke; Eckhard Wolf
Diabetes February 2010, Vol.59, 1228-1238. doi:https://doi.org/10.2337/db09-0519
Complications
Effect of Prior Intensive Therapy in Type 1 Diabetes on 10-Year Progression of Retinopathy in the DCCT/EDIC: Comparison of Adults and Adolescents
Neil H. White; Wanjie Sun; Patricia A. Cleary; William V. Tamborlane; Ronald P. Danis; Dean P. Hainsworth; Matthew D. Davis; for the DCCT-EDIC Research Group
Diabetes February 2010, Vol.59, 1244-1253. doi:https://doi.org/10.2337/db09-1216
Pharmacology and Therapeutics
Associations of Hyperglycemia and Insulin Usage With the Risk of Cancer in Type 2 Diabetes: The Hong Kong Diabetes Registry
Xilin Yang; Gary T.C. Ko; Wing Yee So; Ronald C.W. Ma; Linda W.L. Yu; Alice P.S. Kong; Hailu Zhao; Chun-Chung Chow; Peter C.Y. Tong; Juliana C.N. Chan
Diabetes February 2010, Vol.59, 1254-1260. doi:https://doi.org/10.2337/db09-1371
Genetics
Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans
Erik Ingelsson; Claudia Langenberg; Marie-France Hivert; Inga Prokopenko; Valeriya Lyssenko; Josée Dupuis; Reedik Mägi; Stephen Sharp; Anne U. Jackson; Themistocles L. Assimes; Peter Shrader; Joshua W. Knowles; Björn Zethelius; Fahim A. Abbasi; Richard N. Bergman; Antje Bergmann; Christian Berne; Michael Boehnke; Lori L. Bonnycastle; Stefan R. Bornstein; Thomas A. Buchanan; Suzannah J. Bumpstead; Yvonne Böttcher; Peter Chines; Francis S. Collins; Cyrus C. Cooper; Elaine M. Dennison; Michael R. Erdos; Ele Ferrannini; Caroline S. Fox; Jürgen Graessler; Ke Hao; Bo Isomaa; Karen A. Jameson; Peter Kovacs; Johanna Kuusisto; Markku Laakso; Claes Ladenvall; Karen L. Mohlke; Mario A. Morken; Narisu Narisu; David M. Nathan; Laura Pascoe; Felicity Payne; John R. Petrie; Avan A. Sayer; Peter E. H. Schwarz; Laura J. Scott; Heather M. Stringham; Michael Stumvoll; Amy J. Swift; Ann-Christine Syvänen; Tiinamaija Tuomi; Jaakko Tuomilehto; Anke Tönjes; Timo T. Valle; Gordon H. Williams; Lars Lind; Inês Barroso; Thomas Quertermous; Mark Walker; Nicholas J. Wareham; James B. Meigs; Mark I. McCarthy; Leif Groop; Richard M. Watanabe; Jose C. Florez; on behalf of the MAGIC investigators
Diabetes February 2010, Vol.59, 1266-1275. doi:https://doi.org/10.2337/db09-1568
Variants in ASK1 Are Associated With Skeletal Muscle ASK1 Expression, In Vivo Insulin Resistance, and Type 2 Diabetes in Pima Indians
Li Bian; Robert L. Hanson; Victoria Ossowski; Kim Wiedrich; Clinton C. Mason; Michael Traurig; Yunhua L. Muller; Sayuko Kobes; William C. Knowler; Leslie J. Baier; Clifton Bogardus
Diabetes February 2010, Vol.59, 1276-1282. doi:https://doi.org/10.2337/db09-1700
Brief Report
Pathophysiology
Lipoprotein-Associated Phospholipase A2 Activity and Incident Coronary Heart Disease Among Men and Women With Type 2 Diabetes
Diabetes February 2010, Vol.59, 1239-1243. doi:https://doi.org/10.2337/db09-0730
Pharmacology and Therapeutics
Treatment With Recombinant Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Alleviates the Severity of Streptozotocin-Induced Diabetes
Giorgio Zauli; Barbara Toffoli; Maria Grazia di Iasio; Claudio Celeghini; Bruno Fabris; Paola Secchiero
Diabetes February 2010, Vol.59, 1261-1265. doi:https://doi.org/10.2337/db09-1771
