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Issues
Perspectives in Diabetes
Islet Transplantation a Decade Later and Strategies for Filling a Half-Full Glass
Diabetes June 2010, Vol.59, 1285-1291. doi:https://doi.org/10.2337/db09-1846
Original Article
New Methodologies and Databases
Local Non-Esterified Fatty Acids Correlate With Inflammation in Atheroma Plaques of Patients With Type 2 Diabetes
Sebastián Mas; Roxana Martínez-Pinna; Jose Luis Martín-Ventura; Raul Pérez; Dulcenombre Gomez-Garre; Alberto Ortiz; Arturo Fernandez-Cruz; Fernando Vivanco; Jesús Egido
Diabetes March 2010, Vol.59, 1292-1301. doi:https://doi.org/10.2337/db09-0848
Metabolism
Molecular Characterization of Insulin-Mediated Suppression of Hepatic Glucose Production In Vivo
Christopher J. Ramnanan; Dale S. Edgerton; Noelia Rivera; Jose Irimia-Dominguez; Ben Farmer; Doss W. Neal; Margaret Lautz; E. Patrick Donahue; Catalina M. Meyer; Peter J. Roach; Alan D. Cherrington
Diabetes February 2010, Vol.59, 1302-1311. doi:https://doi.org/10.2337/db09-1625
PTEN Inhibition Improves Muscle Regeneration in Mice Fed a High-Fat Diet
Diabetes March 2010, Vol.59, 1312-1320. doi:https://doi.org/10.2337/db09-1155
Effect of Endogenous GLP-1 on Insulin Secretion in Type 2 Diabetes
Diabetes March 2010, Vol.59, 1330-1337. doi:https://doi.org/10.2337/db09-1253
Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue
Vanessa P. Houde; Sophie Brûlé; William T. Festuccia; Pierre-Gilles Blanchard; Kerstin Bellmann; Yves Deshaies; André Marette
Diabetes March 2010, Vol.59, 1338-1348. doi:https://doi.org/10.2337/db09-1324
Mechanisms of Insulin Resistance After Insulin-Induced Hypoglycemia in Humans: The Role of Lipolysis
Paola Lucidi; Paolo Rossetti; Francesca Porcellati; Simone Pampanelli; Paola Candeloro; Anna Marinelli Andreoli; Gabriele Perriello; Geremia B. Bolli; Carmine G. Fanelli
Diabetes March 2010, Vol.59, 1349-1357. doi:https://doi.org/10.2337/db09-0745
TBC1D1 Regulates Insulin- and Contraction-Induced Glucose Transport in Mouse Skeletal Muscle
Ding An; Taro Toyoda; Eric B. Taylor; Haiyan Yu; Nobuharu Fujii; Michael F. Hirshman; Laurie J. Goodyear
Diabetes March 2010, Vol.59, 1358-1365. doi:https://doi.org/10.2337/db09-1266
Alterations in Skeletal Muscle Fatty Acid Handling Predisposes Middle-Aged Mice to Diet-Induced Insulin Resistance
Debby P.Y. Koonen; Miranda M.Y. Sung; Cindy K.C. Kao; Vernon W. Dolinsky; Timothy R. Koves; Olga Ilkayeva; René L. Jacobs; Dennis E. Vance; Peter E. Light; Deborah M. Muoio; Maria Febbraio; Jason R.B. Dyck
Diabetes March 2010, Vol.59, 1366-1375. doi:https://doi.org/10.2337/db09-1142
Lipocalin-2 Deficiency Impairs Thermogenesis and Potentiates Diet-Induced Insulin Resistance in Mice
Hong Guo; Daozhong Jin; Yuanyuan Zhang; Wendy Wright; Merlijn Bazuine; David A. Brockman; David A. Bernlohr; Xiaoli Chen
Diabetes March 2010, Vol.59, 1376-1385. doi:https://doi.org/10.2337/db09-1735
Signal Transduction
Activation of AMP-Activated Protein Kinase Inhibits Oxidized LDL-Triggered Endoplasmic Reticulum Stress In Vivo
Yunzhou Dong; Miao Zhang; Shuangxi Wang; Bin Liang; Zhengxing Zhao; Chao Liu; Mingyuan Wu; Hyoung Chul Choi; Timothy J. Lyons; Ming-Hui Zou
Diabetes March 2010, Vol.59, 1386-1396. doi:https://doi.org/10.2337/db09-1637
Fat Cell–Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism
Anil Kumar; John C. Lawrence, Jr.; Dae Young Jung; Hwi Jin Ko; Susanna R. Keller; Jason K. Kim; Mark A. Magnuson; Thurl E. Harris
Diabetes March 2010, Vol.59, 1397-1406. doi:https://doi.org/10.2337/db09-1061
Obesity Studies
Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α Overexpression Increases Lipid Oxidation in Myocytes From Extremely Obese Individuals
Leslie A. Consitt; Jill A. Bell; Timothy R. Koves; Deborah M. Muoio; Matthew W. Hulver; Kimberly R. Haynie; G. Lynis Dohm; Joseph A. Houmard
Diabetes March 2010, Vol.59, 1407-1415. doi:https://doi.org/10.2337/db09-1704
Critical Role of the Mesenteric Depot Versus Other Intra-abdominal Adipose Depots in the Development of Insulin Resistance in Young Rats
Diabetes March 2010, Vol.59, 1416-1423. doi:https://doi.org/10.2337/db08-0675
Deletion of the α-Arrestin Protein Txnip in Mice Promotes Adiposity and Adipogenesis While Preserving Insulin Sensitivity
William A. Chutkow; Andreas L. Birkenfeld; Jonathan D. Brown; Hui-Young Lee; David W. Frederick; Jun Yoshioka; Parth Patwari; Romy Kursawe; Samuel W. Cushman; Jorge Plutzky; Gerald I. Shulman; Varman T. Samuel; Richard T. Lee
Diabetes March 2010, Vol.59, 1424-1434. doi:https://doi.org/10.2337/db09-1212
Islet Studies
Ectopic Expression of E2F1 Stimulates β-Cell Proliferation and Function
Gael Grouwels; Ying Cai; Inge Hoebeke; Gunter Leuckx; Yves Heremans; Ulrike Ziebold; Geert Stangé; Marie Chintinne; Zhidong Ling; Daniel Pipeleers; Harry Heimberg; Mark Van de Casteele
Diabetes March 2010, Vol.59, 1435-1444. doi:https://doi.org/10.2337/db09-1295
Immunology and Transplantation
Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression
Timothy I.M. Tree; Jennifer Lawson; Hannah Edwards; Ania Skowera; Sefina Arif; Bart O. Roep; Mark Peakman
Diabetes March 2010, Vol.59, 1451-1460. doi:https://doi.org/10.2337/db09-0503
Prevention of Diabetes by FTY720-Mediated Stabilization of Peri-Islet Tertiary Lymphoid Organs
Diabetes March 2010, Vol.59, 1461-1468. doi:https://doi.org/10.2337/db09-1129
Caspase Inhibitor Therapy Synergizes With Costimulation Blockade to Promote Indefinite Islet Allograft Survival
Juliet A. Emamaullee; Joy Davis; Rena Pawlick; Christian Toso; Shaheed Merani; Sui-Xiong Cai; Ben Tseng; A.M. James Shapiro
Diabetes March 2010, Vol.59, 1469-1477. doi:https://doi.org/10.2337/db09-0502
Idd9.2 and Idd9.3 Protective Alleles Function in CD4+ T-Cells and Nonlymphoid Cells to Prevent Expansion of Pathogenic Islet-Specific CD8+ T-Cells
Emma E. Hamilton-Williams; S.B. Justin Wong; Xavier Martinez; Daniel B. Rainbow; Kara M. Hunter; Linda S. Wicker; Linda A. Sherman
Diabetes March 2010, Vol.59, 1478-1486. doi:https://doi.org/10.2337/db09-1801
Pathophysiology
Platelet Tissue Factor Synthesis in Type 2 Diabetic Patients Is Resistant to Inhibition by Insulin
Diabetes March 2010, Vol.59, 1487-1495. doi:https://doi.org/10.2337/db09-1008
High-Mobility Group Box-1 Protein Promotes Angiogenesis After Peripheral Ischemia in Diabetic Mice Through a VEGF-Dependent Mechanism
Federico Biscetti; Giuseppe Straface; Raimondo De Cristofaro; Stefano Lancellotti; Paola Rizzo; Vincenzo Arena; Egidio Stigliano; Giovanni Pecorini; Kensuke Egashira; Giulia De Angelis; Giovanni Ghirlanda; Andrea Flex
Diabetes March 2010, Vol.59, 1496-1505. doi:https://doi.org/10.2337/db09-1507
Complications
Cardiac-Specific IGF-1 Receptor Transgenic Expression Protects Against Cardiac Fibrosis and Diastolic Dysfunction in a Mouse Model of Diabetic Cardiomyopathy
Karina Huynh; Julie R. McMullen; Tracey L. Julius; Joon Win Tan; Jane E. Love; Nelly Cemerlang; Helen Kiriazis; Xiao-Jun Du; Rebecca H. Ritchie
Diabetes March 2010, Vol.59, 1512-1520. doi:https://doi.org/10.2337/db09-1456
Influence of Insulin in the Ventromedial Hypothalamus on Pancreatic Glucagon Secretion In Vivo
Sachin A. Paranjape; Owen Chan; Wanling Zhu; Adam M. Horblitt; Ewan C. McNay; James A. Cresswell; Jonathan S. Bogan; Rory J. McCrimmon; Robert S. Sherwin
Diabetes March 2010, Vol.59, 1521-1527. doi:https://doi.org/10.2337/db10-0014
Genetics
MTNR1B G24E Variant Associates With BMI and Fasting Plasma Glucose in the General Population in Studies of 22,142 Europeans
Ehm A. Andersson; Birgitte Holst; Thomas Sparsø; Niels Grarup; Karina Banasik; Johan Holmkvist; Torben Jørgensen; Knut Borch-Johnsen; Kristoffer L. Egerod; Torsten Lauritzen; Thorkild I.A. Sørensen; Amélie Bonnefond; David Meyre; Philippe Froguel; Thue W. Schwartz; Oluf Pedersen; Torben Hansen
Diabetes March 2010, Vol.59, 1539-1548. doi:https://doi.org/10.2337/db09-1757
Brief Report
Islet Studies
Physiologic and Pharmacologic Modulation of Glucose-Dependent Insulinotropic Polypeptide (GIP) Receptor Expression in β-Cells by Peroxisome Proliferator–Activated Receptor (PPAR)-γ Signaling: Possible Mechanism for the GIP Resistance in Type 2 Diabetes
Diabetes March 2010, Vol.59, 1445-1450. doi:https://doi.org/10.2337/db09-1655
Pathophysiology
Extracellular Fatty Acid Synthase: A Possible Surrogate Biomarker of Insulin Resistance
Jose Manuel Fernandez-Real; Javier A. Menendez; Jose Maria Moreno-Navarrete; Matthias Blüher; Alejandro Vazquez-Martin; María Jesús Vázquez; Francisco Ortega; Carlos Diéguez; Gema Frühbeck; Wifredo Ricart; Antonio Vidal-Puig
Diabetes March 2010, Vol.59, 1506-1511. doi:https://doi.org/10.2337/db09-1756
Genetics
FTO Genetic Variation and Association With Obesity in West Africans and African Americans
Adebowale Adeyemo; Guanjie Chen; Jie Zhou; Daniel Shriner; Ayo Doumatey; Hanxia Huang; Charles Rotimi
Diabetes March 2010, Vol.59, 1549-1554. doi:https://doi.org/10.2337/db09-1252
Association Between CNDP1 Genotype and Diabetic Nephropathy Is Sex Specific
Antien L. Mooyaart; Ana Zutinic; Stephan J.L. Bakker; Diana C. Grootendorst; Nanne Kleefstra; Irene G.M. van Valkengoed; Stefan Böhringer; Henk J.G. Bilo; Friedo W. Dekker; Jan Anthonie Bruijn; Gerjan Navis; Bart Janssen; Hans J. Baelde; Emile De Heer
Diabetes March 2010, Vol.59, 1555-1559. doi:https://doi.org/10.2337/db09-1377