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Issues
Perspectives in Diabetes
Genetics of Type 1 Diabetes: What's Next?
Flemming Pociot; Beena Akolkar; Patrick Concannon; Henry A. Erlich; Cécile Julier; Grant Morahan; Concepcion R. Nierras; John A. Todd; Stephen S. Rich; Jørn Nerup
Topics:
diabetes mellitus, type 1
,
genes
,
genetics
,
genome
,
genome-wide association study
Diabetes July 2010, Vol.59, 1561-1571. doi:https://doi.org/10.2337/db10-0076
Commentaries
Taking Aim at Islet Hormones With GLP-1: Is Insulin or Glucagon the Better Target?
Topics:
glucagon
,
glucagon-like peptide 1
,
hormones
,
insulin
,
glucose
Diabetes July 2010, Vol.59, 1572-1574. doi:https://doi.org/10.2337/db10-0299
The Juvenile Diabetes Research Foundation at Forty: Updates of Research in Type 1 Diabetes
Topics:
diabetes mellitus, type 1
Diabetes July 2010, Vol.59, 1575-1577. doi:https://doi.org/10.2337/db10-0622
New Methodologies and Databases
Reduced Arteriovenous Shunting Capacity After Local Heating and Redistribution of Baseline Skin Blood Flow in Type 2 Diabetes Assessed With Velocity-Resolved Quantitative Laser Doppler Flowmetry
Ingemar Fredriksson; Marcus Larsson; Fredrik H. Nyström; Toste Länne; Carl J. Östgren; Tomas Strömberg
Topics:
laser-doppler flowmetry
,
perfusion
,
skin
,
vascular flow
,
diabetes mellitus, type 2
Diabetes April 2010, Vol.59, 1578-1584. doi:https://doi.org/10.2337/db10-0080
Associations Between Features of Glucose Exposure and A1C: The A1C-Derived Average Glucose (ADAG) Study
Rikke Borg; Judith C. Kuenen; Bendix Carstensen; Hui Zheng; David M. Nathan; Robert J. Heine; Jorn Nerup; Knut Borch-Johnsen; Daniel R. Witte; on behalf of the ADAG Study Group
Topics:
blood glucose
,
glucose
,
continuous glucose monitoring
,
postprandial period
,
diabetes mellitus, type 2
Diabetes April 2010, Vol.59, 1585-1590. doi:https://doi.org/10.2337/db09-1774
Metabolism
Pituitary Adenylate Cyclase-Activating Polypeptide Stimulates Glucose Production via the Hepatic Sympathetic Innervation in Rats
Chun-Xia Yi; Ning Sun; Mariette T. Ackermans; Anneke Alkemade; Ewout Foppen; Jing Shi; Mireille J. Serlie; Ruud M. Buijs; Eric Fliers; Andries Kalsbeek
Diabetes March 2010, Vol.59, 1591-1600. doi:https://doi.org/10.2337/db09-1398
A Prospective Analysis of Elevated Fasting Glucose Levels and Cognitive Function in Older People: Results From PROSPER and the Rotterdam Study
Sjoerd M. Euser; Naveed Sattar; Jacqueline C.M. Witteman; Eduard L.E.M. Bollen; Eric J.G. Sijbrands; Albert Hofman; Ivan J. Perry; Monique M.B. Breteler; Rudi G.J. Westendorp; for PROSPER and the Rotterdam Study
Topics:
cognitive ability
,
fasting blood glucose measurement
,
mental processes
,
follow-up
,
insulin resistance
Diabetes April 2010, Vol.59, 1601-1607. doi:https://doi.org/10.2337/db09-0568
Role of KLF15 in Regulation of Hepatic Gluconeogenesis and Metformin Action
Mototsugu Takashima; Wataru Ogawa; Kumiko Hayashi; Hiroshi Inoue; Shinichi Kinoshita; Yasuo Okamoto; Hiroshi Sakaue; Yu Wataoka; Aki Emi; Yoko Senga; Yasushi Matsuki; Eijiro Watanabe; Ryuji Hiramatsu; Masato Kasuga
Topics:
amino acids
,
enzymes
,
genes
,
gluconeogenesis
,
liver
Diabetes April 2010, Vol.59, 1608-1615. doi:https://doi.org/10.2337/db09-1679
Early Hepatic Insulin Resistance Precedes the Onset of Diabetes in Obese C57BLKS-db/db Mice
Richard C. Davis; Lawrence W. Castellani; Maryam Hosseini; Osnat Ben-Zeev; Hui Z. Mao; Michael M. Weinstein; Dae Young Jung; John Y. Jun; Jason K. Kim; Aldons J. Lusis; Miklós Péterfy
Topics:
insulin
,
mice
,
insulin resistance
,
obesity
,
plasma
Diabetes April 2010, Vol.59, 1616-1625. doi:https://doi.org/10.2337/db09-0878
Leptin Deficiency Causes Insulin Resistance Induced by Uncontrolled Diabetes
Jonathan P. German; Brent E. Wisse; Joshua P. Thaler; Shinsuke Oh-I; David A. Sarruf; Kayoko Ogimoto; Karl J. Kaiyala; Jonathan D. Fischer; Miles E. Matsen; Gerald J. Taborsky, Jr.; Michael W. Schwartz; Gregory J. Morton
Topics:
leptin
,
streptozocin
,
insulin
,
insulin resistance
Diabetes April 2010, Vol.59, 1626-1634. doi:https://doi.org/10.2337/db09-1918
Obesity Studies
PYY3–36 and Oxyntomodulin Can Be Additive in Their Effect on Food Intake in Overweight and Obese Humans
Benjamin C.T. Field; Alison M. Wren; Veronique Peters; Kevin C.R. Baynes; Niamh M. Martin; Michael Patterson; Sara Alsaraf; Vian Amber; Katie Wynne; Mohammad A. Ghatei; Stephen R. Bloom
Topics:
energy intake
,
obesity
,
oxyntomodulin
,
infusion procedures
,
overweight
Diabetes March 2010, Vol.59, 1635-1639. doi:https://doi.org/10.2337/db09-1859
Cardiorespiratory Fitness and Insulin Sensitivity in Overweight or Obese Subjects May Be Linked Through Intrahepatic Lipid Content
Sven Haufe; Stefan Engeli; Petra Budziarek; Wolfgang Utz; Jeanette Schulz-Menger; Mario Hermsdorf; Susanne Wiesner; Christoph Otto; Verena Haas; Armin de Greiff; Friedrich C. Luft; Michael Boschmann; Jens Jordan
Topics:
body fat
,
insulin sensitivity
,
lipids
,
obesity
,
overweight
Diabetes March 2010, Vol.59, 1640-1647. doi:https://doi.org/10.2337/db09-1200
Pro-Inflammatory CD11c+CD206+ Adipose Tissue Macrophages Are Associated With Insulin Resistance in Human Obesity
John M. Wentworth; Gaetano Naselli; Wendy A. Brown; Lisa Doyle; Belinda Phipson; Gordon K. Smyth; Martin Wabitsch; Paul E. O'Brien; Leonard C. Harrison
Topics:
adipose tissue
,
crowns
,
flow cytometry
,
insulin resistance
,
obesity
Diabetes March 2010, Vol.59, 1648-1656. doi:https://doi.org/10.2337/db09-0287
Identification of Body Fat Mass as a Major Determinant of Metabolic Rate in Mice
Karl J. Kaiyala; Gregory J. Morton; Brian G. Leroux; Kayoko Ogimoto; Brent Wisse; Michael W. Schwartz
Diabetes April 2010, Vol.59, 1657-1666. doi:https://doi.org/10.2337/db09-1582
Combined Analyses of 20 Common Obesity Susceptibility Variants
Camilla Helene Sandholt; Thomas Sparsø; Niels Grarup; Anders Albrechtsen; Katrine Almind; Lars Hansen; Ulla Toft; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Topics:
obesity
,
overweight
,
single nucleotide polymorphism
Diabetes January 2010, Vol.59, 1667-1673. doi:https://doi.org/10.2337/db09-1042
Islet Studies
The Transcription Factor Rfx3 Regulates β-Cell Differentiation, Function, and Glucokinase Expression
Aouatef Ait-Lounis; Claire Bonal; Queralt Seguín-Estévez; Christoph D. Schmid; Philipp Bucher; Pedro L. Herrera; Bénédicte Durand; Paolo Meda; Walter Reith
Topics:
embryo
,
glucokinase
,
insulin
,
mice
,
pancreas
Diabetes April 2010, Vol.59, 1674-1685. doi:https://doi.org/10.2337/db09-0986
Inhibition of β-Cell Sodium-Calcium Exchange Enhances Glucose-Dependent Elevations in Cytoplasmic Calcium and Insulin Secretion
Kevin S.C. Hamming; Daniel Soliman; Nicola J. Webster; Gavin J. Searle; Laura C. Matemisz; David A. Liknes; Xiao-Qing Dai; Thomas Pulinilkunnil; Michael J. Riedel; Jason R.B. Dyck; Patrick E. MacDonald; Peter E. Light
Topics:
calcium
,
glucose
,
insulin secretion
,
cytoplasm
,
mice
Diabetes April 2010, Vol.59, 1686-1693. doi:https://doi.org/10.2337/db09-0630
γ-Aminobutyric Acid (GABA) Is an Autocrine Excitatory Transmitter in Human Pancreatic β-Cells
Matthias Braun; Reshma Ramracheya; Martin Bengtsson; Anne Clark; Jonathan N. Walker; Paul R. Johnson; Patrik Rorsman
Topics:
gamma-aminobutyric acid
,
glucose
Diabetes April 2010, Vol.59, 1694-1701. doi:https://doi.org/10.2337/db09-0797
β-Cell Replication Is Increased in Donor Organs From Young Patients After Prolonged Life Support
Peter In't Veld; Neelke De Munck; Kristien Van Belle; Nicole Buelens; Zhidong Ling; Ilse Weets; Patrick Haentjens; Miriam Pipeleers-Marichal; Frans Gorus; Daniel Pipeleers
Topics:
donors
,
life support procedure
,
pancreas
,
organ donation
,
cd68 antigen, human
Diabetes April 2010, Vol.59, 1702-1708. doi:https://doi.org/10.2337/db09-1698
Regulation of MafA Expression in Pancreatic β-Cells in db/db Mice With Diabetes
Taka-aki Matsuoka; Hideaki Kaneto; Takeshi Miyatsuka; Tsunehiko Yamamoto; Kaoru Yamamoto; Ken Kato; Iichiro Shimomura; Roland Stein; Munehide Matsuhisa
Diabetes April 2010, Vol.59, 1709-1720. doi:https://doi.org/10.2337/db08-0693
Immunology and Transplantation
Simultaneous Detection of Circulating Autoreactive CD8+ T-Cells Specific for Different Islet Cell–Associated Epitopes Using Combinatorial MHC Multimers
Jurjen H. Velthuis; Wendy W. Unger; Joana R.F. Abreu; Gaby Duinkerken; Kees Franken; Mark Peakman; Arnold H. Bakker; Sine Reker-Hadrup; Bart Keymeulen; Jan Wouter Drijfhout; Ton N. Schumacher; Bart O. Roep
Topics:
epitopes
,
hla-a2 antigen
,
t-lymphocytes
,
endocrine pancreas
,
insulin
Diabetes March 2010, Vol.59, 1721-1730. doi:https://doi.org/10.2337/db09-1486
Redox Modulation Protects Islets From Transplant-Related Injury
Martha M. Sklavos; Suzanne Bertera; Hubert M. Tse; Rita Bottino; Jing He; Joshua N. Beilke; Marilyne G. Coulombe; Ronald G. Gill; James D. Crapo; Massimo Trucco; Jon D. Piganelli
Topics:
antioxidants
,
streptozocin
,
transplantation
,
mice
,
catalysis
Diabetes April 2010, Vol.59, 1731-1738. doi:https://doi.org/10.2337/db09-0588
Sitagliptin (MK0431) Inhibition of Dipeptidyl Peptidase IV Decreases Nonobese Diabetic Mouse CD4+ T-Cell Migration Through Incretin-Dependent and -Independent Pathways
Topics:
incretin
,
lymph nodes
,
mice, inbred nod
,
sitagliptin
,
spleen
Diabetes April 2010, Vol.59, 1739-1750. doi:https://doi.org/10.2337/db09-1618
Monocyte Gene-Expression Profiles Associated With Childhood-Onset Type 1 Diabetes and Disease Risk: A Study of Identical Twins
Huriya Beyan; Roosmarijn C. Drexhage; Leonie van der Heul Nieuwenhuijsen; Harm de Wit; Roosmarijn C. Padmos; Nanette C. Schloot; Hemmo A. Drexhage; Richard David Leslie
Topics:
child
,
diabetes mellitus, type 1
,
gene expression
,
monocytes
,
twins
Diabetes April 2010, Vol.59, 1751-1755. doi:https://doi.org/10.2337/db09-1433
Pathophysiology
Quantification and Three-Dimensional Imaging of the Insulitis-Induced Destruction of β-Cells in Murine Type 1 Diabetes
Tomas Alanentalo; Andreas Hörnblad; Sofia Mayans; Anna Karin Nilsson; James Sharpe; Åsa Larefalk; Ulf Ahlgren; Dan Holmberg
Topics:
diabetes mellitus, type 1
,
insulin
,
mice
,
mice, inbred nod
,
pancreas
Diabetes April 2010, Vol.59, 1756-1764. doi:https://doi.org/10.2337/db09-1400
The Glucagonostatic and Insulinotropic Effects of Glucagon-Like Peptide 1 Contribute Equally to Its Glucose-Lowering Action
Topics:
glucagon
,
glucagon-like peptide 1
,
glucose
,
insulin
,
somatostatin
Diabetes July 2010, Vol.59, 1765-1770. doi:https://doi.org/10.2337/db09-1414
Lipoprotein Subfraction Cholesterol Distribution Is Proatherogenic in Women With Type 1 Diabetes and Insulin Resistance
David M. Maahs; John E. Hokanson; Hong Wang; Gregory L. Kinney; Janet K. Snell-Bergeon; Ashley East; Bryan C. Bergman; Irene E. Schauer; Marian Rewers; Robert H. Eckel
Topics:
cholesterol
,
diabetes mellitus, type 1
,
insulin resistance
,
lipoproteins
,
statins
Diabetes April 2010, Vol.59, 1771-1779. doi:https://doi.org/10.2337/db09-1626
Profile of Lipid and Protein Autacoids in Diabetic Vitreous Correlates With the Progression of Diabetic Retinopathy
Michal Laniado Schwartzman; Pavel Iserovich; Katherine Gotlinger; Lars Bellner; Michael W. Dunn; Mauro Sartore; Maria Grazia Pertile; Andrea Leonardi; Sonal Sathe; Ann Beaton; Lynn Trieu; Robert Sack
Topics:
autacoids
,
lipids
,
nonproliferative diabetic retinopathy
,
vitreous body
,
diabetic retinopathy
Diabetes April 2010, Vol.59, 1780-1788. doi:https://doi.org/10.2337/db10-0110
Impact of Age on the Relationships of Brown Adipose Tissue With Sex and Adiposity in Humans
Christina Pfannenberg; Matthias K. Werner; Sabine Ripkens; Irina Stef; Annette Deckert; Maria Schmadl; Matthias Reimold; Hans-Ulrich Häring; Claus D. Claussen; Norbert Stefan
Topics:
brown fat
,
computed tomography/positron emission tomography imaging
,
obesity
,
body mass index procedure
,
fluorodeoxyglucose f18
Diabetes April 2010, Vol.59, 1789-1793. doi:https://doi.org/10.2337/db10-0004
Complications
E-Cadherin Expression Is Regulated by miR-192/215 by a Mechanism That Is Independent of the Profibrotic Effects of Transforming Growth Factor-β
Bo Wang; Michal Herman-Edelstein; Philip Koh; Wendy Burns; Karin Jandeleit-Dahm; Anna Watson; Moin Saleem; Gregory J. Goodall; Stephen M. Twigg; Mark E. Cooper; Phillip Kantharidis
Topics:
connective tissue growth factor
,
e-cadherin
,
kidney
,
micrornas
,
rna, messenger
Diabetes April 2010, Vol.59, 1794-1802. doi:https://doi.org/10.2337/db09-1736
Cumulative Risk, Age at Onset, and Sex-Specific Differences for Developing End-Stage Renal Disease in Young Patients With Type 1 Diabetes: A Nationwide Population-Based Cohort Study
Anna Möllsten; Maria Svensson; Ingeborg Waernbaum; Yonas Berhan; Staffan Schön; Lennarth Nyström; Hans J. Arnqvist; Gisela Dahlquist; for the Swedish Childhood Diabetes Study Group, the Diabetes Incidence Study in Sweden, and the Swedish Renal Registry
Diabetes April 2010, Vol.59, 1803-1808. doi:https://doi.org/10.2337/db09-1744
Inhibition of Connective Tissue Growth Factor Overexpression in Diabetic Retinopathy by SERPINA3K via Blocking the WNT/β-Catenin Pathway
Topics:
connective tissue growth factor
,
diabetic retinopathy
,
glucose
,
protein overexpression
,
retina
Diabetes March 2010, Vol.59, 1809-1816. doi:https://doi.org/10.2337/db09-1056
Pharmacology and Therapeutics
Fibroblast Growth Factor 21 Action in the Brain Increases Energy Expenditure and Insulin Sensitivity in Obese Rats
David A. Sarruf; Joshua P. Thaler; Gregory J. Morton; Jonathan German; Jonathan D. Fischer; Kayoko Ogimoto; Michael W. Schwartz
Topics:
infusion procedures
,
insulin
,
insulin sensitivity
,
obesity
,
rats
Diabetes April 2010, Vol.59, 1817-1824. doi:https://doi.org/10.2337/db09-1878
Resveratrol Inhibits Neuronal Apoptosis and Elevated Ca2+/Calmodulin-Dependent Protein Kinase II Activity in Diabetic Mouse Retina
Topics:
in situ nick-end labeling
,
mice
,
phosphotransferases
,
resveratrol
,
retina
Diabetes April 2010, Vol.59, 1825-1835. doi:https://doi.org/10.2337/db09-1431
Genetics
Spectrum of HNF1A Somatic Mutations in Hepatocellular Adenoma Differs From That in Patients With MODY3 and Suggests Genotoxic Damage
Emmanuelle Jeannot; Lucille Mellottee; Paulette Bioulac-Sage; Charles Balabaud; Jean-Yves Scoazec; Jeanne Tran Van Nhieu; Yannick Bacq; Sophie Michalak; David Buob; Groupe d'étude Génétique des Tumeurs Hépatiques (INSERM Network); Pierre Laurent-Puig; Ivan Rusyn; Jessica Zucman-Rossi
Topics:
hnf1a gene
,
mutation
,
liver
,
liver cell adenoma
Diabetes April 2010, Vol.59, 1836-1844. doi:https://doi.org/10.2337/db09-1819
Increased Expression of β-N-Acetylglucosaminidase in Erythrocytes From Individuals With Pre-diabetes and Diabetes
Topics:
erythrocytes
,
prediabetes
,
western blotting
,
beta-n-acetylglucosaminidase
,
hemoglobin
Diabetes April 2010, Vol.59, 1845-1850. doi:https://doi.org/10.2337/db09-1086
Online Letters to the Editor
Response to Comment on: Jowett et al. (2010) Genetic Variation at the FTO Locus Influences RBL2 Gene Expression. Diabetes;59:726–732
Topics:
fto gene
,
genetics
,
rbl2 gene
,
single nucleotide polymorphism
Diabetes July 2010, Vol.59, e10. doi:https://doi.org/10.2337/db10-0443
Comment on: Tikhonenko et al. (2010) Remodeling of Retinal Fatty Acids in an Animal Model of Diabetes: A Decrease in Long-Chain Polyunsaturated Fatty Acids Is Associated with a Decrease in Fatty Acid Elongases Elovl2 and Elovl4. Diabetes;59:219–227
Diabetes July 2010, Vol.59, e11. doi:https://doi.org/10.2337/db10-0430
Response to Comment on: Tikhonenko et al. (2010) Remodeling of Retinal Fatty Acids in an Animal Model of Diabetes: A Decrease in Long-Chain Polyunsaturated Fatty Acids Is Associated with a Decrease in Fatty Acid Elongases Elovl2 and Elovl4. Diabetes;59:219–227
Diabetes July 2010, Vol.59, e12. doi:https://doi.org/10.2337/db10-0623
Comment on: Biscetti et al. (2010) High-Mobility Group Box-1 Protein Promotes Angiogenesis After Peripheral Ischemia in Diabetic Mice Through a VEGF-Dependent Mechanism. Diabetes;59:1496–1505
Topics:
angiogenesis
,
ischemia, peripheral
,
mice
,
mobility
,
vascular endothelial growth factor a
Diabetes July 2010, Vol.59, e7. doi:https://doi.org/10.2337/db10-0445
Response to Comment on: Biscetti et al. (2010) High-Mobility Group Box-1 Protein Promotes Angiogenesis After Peripheral Ischemia in Diabetic Mice Through a VEGF-Dependent Mechanism. Diabetes;59:1496–1505
Topics:
angiogenesis
,
ischemia, peripheral
,
mice
,
mobility
,
vascular endothelial growth factor a
Diabetes July 2010, Vol.59, e8. doi:https://doi.org/10.2337/db10-0494
Comment on: Jowett et al. (2010) Genetic Variation at the FTO Locus Influences RBL2 Gene Expression. Diabetes;59:726–732
Topics:
fto gene
,
genetics
,
rbl2 gene
,
single nucleotide polymorphism
Diabetes July 2010, Vol.59, e9. doi:https://doi.org/10.2337/db10-0337
