Issues

Topics: blood pressure , diabetes mellitus, type 1 , diabetes mellitus, type 2 , epidemiology , glycemic control

Diabetes August 2010, Vol.59, 1853-1860. doi:https://doi.org/10.2337/db09-1904

Commentaries

β-Cells Step Up in Controlling the Autoimmune Response

Paolo Fiorina

Abstracts

Topics: autoimmunity , molecule , programmed cell death 1 ligand 1 , t-lymphocytes , immune system

Diabetes August 2010, Vol.59, 1861-1864. doi:https://doi.org/10.2337/db10-0662

Getting a Notch Closer to Understanding Diabetic Kidney Disease

Seon-Ho Ahn; Katalin Susztak

Abstracts

Topics: diabetic nephropathy , podocytes , vascular endothelial growth factor a , kidney , albuminuria

Diabetes August 2010, Vol.59, 1865-1867. doi:https://doi.org/10.2337/db10-0077

Translating “Nondiabetic” A1C Levels to Clinical Practice: The Art of Medicine

William T. Cefalu

Abstracts

Topics: heart disease risk factors , hyperglycemia , translating , cardiovascular diseases , diabetes mellitus, type 2

Diabetes August 2010, Vol.59, 1868-1869. doi:https://doi.org/10.2337/db10-0800

Metabolism

The SNARE Protein SNAP23 and the SNARE-Interacting Protein Munc18c in Human Skeletal Muscle Are Implicated in Insulin Resistance/Type 2 Diabetes

Pontus Boström; Linda Andersson; Birgitte Vind; Liliana Håversen; Mikael Rutberg; Ylva Wickström; Erik Larsson; Per-Anders Jansson; Maria K. Svensson; Richard Brånemark; Charlotte Ling; Henning Beck-Nielsen; Jan Borén; Kurt Højlund; Sven-Olof Olofsson

Abstracts

Topics: diabetes mellitus, type 2 , skeletal muscles , insulin resistance , cytosol

Diabetes May 2010, Vol.59, 1870-1878. doi:https://doi.org/10.2337/db09-1503

Atrogin-1 Affects Muscle Protein Synthesis and Degradation When Energy Metabolism Is Impaired by the Antidiabetes Drug Berberine

Huiling Wang; Dajun Liu; Peirang Cao; Stewart Lecker; Zhaoyong Hu

Abstracts

Topics: berberine , muscle proteins , mice , muscular atrophy , protein biosynthesis

Diabetes June 2010, Vol.59, 1879-1889. doi:https://doi.org/10.2337/db10-0207

Leptin Directly Depolarizes Preproglucagon Neurons in the Nucleus Tractus Solitarius: Electrical Properties of Glucagon-Like Peptide 1 Neurons

Kazunari Hisadome; Frank Reimann; Fiona M. Gribble; Stefan Trapp

Abstracts

Topics: glucagon-like peptide 1 , leptin , neurons , preproglucagon , brain stem

Diabetes June 2010, Vol.59, 1890-1898. doi:https://doi.org/10.2337/db10-0128

Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women

Marleen Kars; Ling Yang; Margaret F. Gregor; B. Selma Mohammed; Terri A. Pietka; Brian N. Finck; Bruce W. Patterson; Jay D. Horton; Bettina Mittendorfer; Gökhan S. Hotamisligil; Samuel Klein

Abstracts

Topics: adipose tissue , glucose , insulin , insulin resistance , insulin sensitivity

Diabetes June 2010, Vol.59, 1899-1905. doi:https://doi.org/10.2337/db10-0308

Signal Transduction

T-Cell Protein Tyrosine Phosphatase Attenuates STAT3 and Insulin Signaling in the Liver to Regulate Gluconeogenesis

Atsushi Fukushima; Kim Loh; Sandra Galic; Barbara Fam; Ben Shields; Florian Wiede; Michel L. Tremblay; Matthew J. Watt; Sofianos Andrikopoulos; Tony Tiganis

Abstracts

Topics: gluconeogenesis , insulin , interleukin-6 , liver , mice

Diabetes May 2010, Vol.59, 1906-1914. doi:https://doi.org/10.2337/db09-1365

Modulation of Notch-1 Signaling Alleviates Vascular Endothelial Growth Factor–Mediated Diabetic Nephropathy

Chun-Liang Lin; Feng-Sheng Wang; Yen-Chen Hsu; Cheng-Nan Chen; Min-Jen Tseng; Moin A. Saleem; Pey-Jium Chang; Jeng-Yi Wang

Abstracts

Topics: hek293 cells , podocytes , signal transduction , vascular endothelial growth factor a , diabetic nephropathy

Diabetes June 2010, Vol.59, 1915-1925. doi:https://doi.org/10.2337/db09-0663

Islet Studies

Induction of Human β-Cell Proliferation and Engraftment Using a Single G1/S Regulatory Molecule, cdk6

Nathalie M. Fiaschi-Taesch; Fatimah Salim; Jeffrey Kleinberger; Ronnie Troxell; Irene Cozar-Castellano; Karen Selk; Edward Cherok; Karen K. Takane; Donald K. Scott; Andrew F. Stewart

Abstracts

Topics: cyclin d1 , cyclins , molecule , cyclin-dependent kinase 4 , protein overexpression

Diabetes August 2010, Vol.59, 1926-1936. doi:https://doi.org/10.2337/db09-1776

PERK (EIF2AK3) Regulates Proinsulin Trafficking and Quality Control in the Secretory Pathway

Sounak Gupta; Barbara McGrath; Douglas R. Cavener

Abstracts

Topics: emergency service, hospital , golgi apparatus , insulin , mice , proinsulin

Diabetes June 2010, Vol.59, 1937-1947. doi:https://doi.org/10.2337/db09-1064

Mesenchymal Bone Morphogenetic Protein Signaling Is Required for Normal Pancreas Development

Jonas Ahnfelt-Rønne; Philippe Ravassard; Corinne Pardanaud-Glavieux; Raphaél Scharfmann; Palle Serup

Abstracts

Topics: mesenchyme , pancreas , embryo , signal transduction , epithelium

Diabetes June 2010, Vol.59, 1948-1956. doi:https://doi.org/10.2337/db09-1010

Increased β-Cell Mass by Islet Transplantation and PLAG1 Overexpression Causes Hyperinsulinemic Normoglycemia and Hepatic Insulin Resistance in Mice

Jeroen Declercq; Anujith Kumar; Janna A. Van Diepen; Irene O.C.M. Vroegrijk; Conny Gysemans; Caterina Di Pietro; Peter J. Voshol; Chantal Mathieu; Nadine Ectors; Wim J.M. Van de Ven; Catherine M. Verfaillie

Abstracts

Topics: insulin , mice , transplantation , insulin resistance , glucose

Diabetes June 2010, Vol.59, 1957-1965. doi:https://doi.org/10.2337/db09-1446

Immunology and Transplantation

Deficiency in B7-H1 (PD-L1)/PD-1 Coinhibition Triggers Pancreatic β-Cell Destruction by Insulin-Specific, Murine CD8 T-Cells

Tarvo Rajasalu; Helen Brosi; Cornelia Schuster; Andreas Spyrantis; Bernhard Otto Boehm; Lieping Chen; Jörg Reimann; Reinhold Schirmbeck

Abstracts

Topics: mice , pancreas , preproinsulin , t-lymphocytes , immunization

Diabetes May 2010, Vol.59, 1966-1973. doi:https://doi.org/10.2337/db09-1135

Pathophysiology

Decreased Circulating Progenitor Cell Number and Failed Mechanisms of Stromal Cell-Derived Factor-1α Mediated Bone Marrow Mobilization Impair Diabetic Tissue Repair

Oren M. Tepper; Jacquelyn Carr; Robert J. Allen, Jr.; Christopher C. Chang; Clarence D. Lin; Rica Tanaka; Sanjeev M. Gupta; Jamie P. Levine; Pierre B. Saadeh; Stephen M. Warren

Abstracts

Topics: bone marrow , wound closure , mice , plerixafor

Diabetes May 2010, Vol.59, 1974-1983. doi:https://doi.org/10.2337/db09-0185

N-Glycosylation of Carnosinase Influences Protein Secretion and Enzyme Activity: Implications for Hyperglycemia

Eva Riedl; Hannes Koeppel; Frederick Pfister; Verena Peters; Sibylle Sauerhoefer; Paula Sternik; Paul Brinkkoetter; Hanswalter Zentgraf; Gerjan Navis; Robert H. Henning; Jacob Van Den Born; Stephan J.L. Bakker; Bart Janssen; Fokko J. van der Woude; Benito A. Yard

Abstracts

Topics: bodily secretions , enzyme activity , glycosylation , hyperglycemia , protein secretion

Diabetes May 2010, Vol.59, 1984-1990. doi:https://doi.org/10.2337/db09-0868

Control of Adipose Tissue Inflammation Through TRB1

Anke Ostertag; Allan Jones; Adam J. Rose; Maria Liebert; Stefan Kleinsorg; Anja Reimann; Alexandros Vegiopoulos; Mauricio Berriel Diaz; Daniela Strzoda; Masahiro Yamamoto; Takashi Satoh; Shizuo Akira; Stephan Herzig

Abstracts

Topics: adipocytes , cytokine , cytokine gene , diet, high-fat , inflammation

Diabetes June 2010, Vol.59, 1991-2000. doi:https://doi.org/10.2337/db09-1537

Increased Cytochrome P4502E1 Expression and Altered Hydroxyeicosatetraenoic Acid Formation Mediate Diabetic Vascular Dysfunction: Rescue by Guanylyl-Cyclase Activation

Andreas Schäfer; Paolo Galuppo; Daniela Fraccarollo; Christian Vogt; Julian D. Widder; Julia Pfrang; Piet Tas; Eduardo Barbosa-Sicard; Hartmut Ruetten; Georg Ertl; Ingrid Fleming; Johann Bauersachs

Abstracts

Topics: aorta , cytochrome p-450 cyp2e1 , cytochromes , hydroxyeicosatetraenoic acids , muscle contraction

Diabetes June 2010, Vol.59, 2001-2009. doi:https://doi.org/10.2337/db09-1668

Complications

Transient Inhibition of Transforming Growth Factor-β1 in Human Diabetic CD34⁺ Cells Enhances Vascular Reparative Functions

Ashay D. Bhatwadekar; E.P. Guerin; Yagna P.R. Jarajapu; Sergio Caballero; Carl Sheridan; David Kent; Laurence Kennedy; M. Cecilia Lansang; Frank W. Ruscetti; Carl J. Pepine; Paul J. Higgins; Stephen H. Bartelmez; Maria B. Grant

Abstracts

Topics: cd34 antigens , mice

Diabetes May 2010, Vol.59, 2010-2019. doi:https://doi.org/10.2337/db10-0287

The Association of Hemoglobin A1c With Incident Heart Failure Among People Without Diabetes: The Atherosclerosis Risk in Communities Study

Kunihiro Matsushita; Saul Blecker; Antonio Pazin-Filho; Alain Bertoni; Patricia P. Chang; Josef Coresh; Elizabeth Selvin

Abstracts

Topics: aric trial , fasting blood glucose measurement , heart failure , hemoglobin a, glycosylated

Diabetes May 2010, Vol.59, 2020-2026. doi:https://doi.org/10.2337/db10-0165

Higher Plasma Soluble Receptor for Advanced Glycation End Products (sRAGE) Levels Are Associated With Incident Cardiovascular Disease and All-Cause Mortality in Type 1 Diabetes: A 12-Year Follow-Up Study

Johanna W.M. Nin; Anders Jorsal; Isabel Ferreira; Casper G. Schalkwijk; Martin H. Prins; Hans-Henrik Parving; Lise Tarnow; Peter Rossing; Coen D.A. Stehouwer

Abstracts

Topics: cardiovascular diseases , diabetes mellitus, type 1 , follow-up , plasma , receptor for advanced glycation endproducts

Diabetes June 2010, Vol.59, 2027-2032. doi:https://doi.org/10.2337/db09-1509

Deficiency of Rac1 Blocks NADPH Oxidase Activation, Inhibits Endoplasmic Reticulum Stress, and Reduces Myocardial Remodeling in a Mouse Model of Type 1 Diabetes

Jianmin Li; Huaqing Zhu; E Shen; Li Wan; J. Malcolm O. Arnold; Tianqing Peng

Abstracts

Topics: heart , mice , nadph oxidases , stress , streptozocin

Diabetes June 2010, Vol.59, 2033-2042. doi:https://doi.org/10.2337/db09-1800

Deletion of the Receptor for Advanced Glycation End Products Reduces Glomerulosclerosis and Preserves Renal Function in the Diabetic OVE26 Mouse

Nina Reiniger; Kai Lau; Daren McCalla; Bonnie Eby; Bin Cheng; Yan Lu; Wu Qu; Nosirudeen Quadri; Radha Ananthakrishnan; Maryana Furmansky; Rosa Rosario; Fei Song; Vivek Rai; Alan Weinberg; Richard Friedman; Ravichandran Ramasamy; Vivette D'Agati; Ann Marie Schmidt

Abstracts

Topics: mice , rage

Diabetes August 2010, Vol.59, 2043-2054. doi:https://doi.org/10.2337/db09-1766

Genetics

HLA DPA1, DPB1 Alleles and Haplotypes Contribute to the Risk Associated With Type 1 Diabetes: Analysis of the Type 1 Diabetes Genetics Consortium Families

Michael D. Varney; Ana Maria Valdes; Joyce A. Carlson; Janelle A. Noble; Brian D. Tait; Persia Bonella; Eva Lavant; Anna Lisa Fear; Anthony Louey; Priscilla Moonsamy; Josyf C. Mychaleckyj; Henry Erlich; for the Type 1 Diabetes Genetics Consortium

Abstracts

Topics: alleles , diabetes mellitus, type 1 , haplotypes , human leukocyte antigens , linkage disequilibrium

Diabetes April 2010, Vol.59, 2055-2062. doi:https://doi.org/10.2337/db09-0680

BMI at Age 8 Years Is Influenced by the Type 2 Diabetes Susceptibility Genes HHEX-IDE and CDKAL1

Christiane Winkler; Ezio Bonifacio; Harald Grallert; Lydia Henneberger; Thomas Illig; Anette-Gabriele Ziegler, MD

Abstracts

Topics: birth weight , body mass index procedure , child , diabetes mellitus, type 1 , diabetes mellitus, type 2

Diabetes May 2010, Vol.59, 2063-2067. doi:https://doi.org/10.2337/db10-0099

Impact of Common Variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the Risk of Type 2 Diabetes in 5,164 Indians

Ganesh Chauhan; Charles J. Spurgeon; Rubina Tabassum; Seema Bhaskar; Smita R. Kulkarni; Anubha Mahajan; Sreenivas Chavali; M.V. Kranthi Kumar; Swami Prakash; Om Prakash Dwivedi; Saurabh Ghosh; Chittaranjan S. Yajnik; Nikhil Tandon; Dwaipayan Bharadwaj; Giriraj R. Chandak

Abstracts

Topics: diabetes mellitus, type 2 , genes, p16 , kcnj11 gene , slc30a8 gene , tcf7l2 gene

Diabetes April 2010, Vol.59, 2068-2074. doi:https://doi.org/10.2337/db09-1386

Replication Study for the Association Between Four Loci Identified by a Genome-Wide Association Study on European American Subjects With Type 1 Diabetes and Susceptibility to Diabetic Nephropathy in Japanese Subjects With Type 2 Diabetes

Shiro Maeda; Shin-ichi Araki; Tetsuya Babazono; Masao Toyoda; Tomoya Umezono; Koichi Kawai; Masahito Imanishi; Takashi Uzu; Hirotaka Watada; Daisuke Suzuki; Atsunori Kashiwagi; Yasuhiko Iwamoto; Kohei Kaku; Ryuzo Kawamori; Yusuke Nakamura

Abstracts

Topics: diabetes mellitus, type 1 , diabetes mellitus, type 2 , diabetic nephropathy , single nucleotide polymorphism , genome-wide association study

Diabetes May 2010, Vol.59, 2075-2079. doi:https://doi.org/10.2337/db10-0067

Functional Variants in MBL2 Are Associated With Type 2 Diabetes and Pre-Diabetes Traits in Pima Indians and the Old Order Amish

Yunhua L. Muller; Robert L. Hanson; Li Bian; Janel Mack; Xiaolian Shi; Ruth Pakyz; Alan R. Shuldiner; William C. Knowler; Clifton Bogardus; Leslie J. Baier

Abstracts