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Issues
Perspectives in Diabetes
Antigen-Specific Immunotherapy for Type 1 Diabetes: Maximizing the Potential
Topics:
antigens
,
diabetes mellitus, type 1
,
immunotherapy
Diabetes September 2010, Vol.59, 2087-2093. doi:https://doi.org/10.2337/db10-0630
Recent Advances and Prospects in the Differentiation of Pancreatic Cells From Human Embryonic Stem Cells
Topics:
endoderm
,
hetastarch
,
pancreas
,
primary eosinophilic endomyocardial cardiomyopathy
,
signal transduction
Diabetes September 2010, Vol.59, 2094-2101. doi:https://doi.org/10.2337/db10-0439
Commentaries
Pancreatic Islet Transplants and IDO: When Starving the Enemy Does You Good
Topics:
endocrine pancreas
,
tissue transplants
,
protein overexpression
,
immune response
,
tryptophan
Diabetes September 2010, Vol.59, 2102-2104. doi:https://doi.org/10.2337/db10-0919
Obesity and Insulin Resistance: An Ongoing Saga
Topics:
insulin resistance
,
obesity
Diabetes September 2010, Vol.59, 2105-2106. doi:https://doi.org/10.2337/db10-0766
Metabolism
Ablation of 4E-BP1/2 Prevents Hyperglycemia-Mediated Induction of VEGF Expression in the Rodent Retina and in Müller Cells in Culture
Tabitha L. Schrufer; David A. Antonetti; Nahum Sonenberg; Scot R. Kimball; Thomas W. Gardner; Leonard S. Jefferson
Topics:
retina
,
rna, messenger
,
vascular endothelial growth factor a
,
hyperglycemic agents
,
diabetes mellitus, type 1
Diabetes June 2010, Vol.59, 2107-2116. doi:https://doi.org/10.2337/db10-0148
Prolonged Fasting Identifies Skeletal Muscle Mitochondrial Dysfunction as Consequence Rather Than Cause of Human Insulin Resistance
Joris Hoeks; Noud A. van Herpen; Marco Mensink; Esther Moonen-Kornips; Denis van Beurden; Matthijs K.C. Hesselink; Patrick Schrauwen
Topics:
fasting
,
insulin
,
insulin resistance
,
intramuscular injections
,
mitochondria
Diabetes June 2010, Vol.59, 2117-2125. doi:https://doi.org/10.2337/db10-0519
Sleep Restriction for 1 Week Reduces Insulin Sensitivity in Healthy Men
Topics:
drowsiness
,
hydrocortisone
,
insulin
,
insulin sensitivity
,
modafinil
Diabetes June 2010, Vol.59, 2126-2133. doi:https://doi.org/10.2337/db09-0699
Kinetics of Contraction-Induced GLUT4 Translocation in Skeletal Muscle Fibers From Living Mice
Topics:
mice
,
sarcolemma
,
translocation (genetics)
,
transverse tubule of muscle cell
,
aica ribonucleotide
Diabetes July 2010, Vol.59, 2134-2144. doi:https://doi.org/10.2337/db10-0233
Ghrelin Suppresses Glucose-Stimulated Insulin Secretion and Deteriorates Glucose Tolerance in Healthy Humans
Jenny Tong; Ronald L. Prigeon; Harold W. Davis; Martin Bidlingmaier; Steven E. Kahn; David E. Cummings; Matthias H. Tschöp; David D'Alessio
Topics:
ghrelin
,
glucose
,
insulin
,
insulin secretion
Diabetes June 2010, Vol.59, 2145-2151. doi:https://doi.org/10.2337/db10-0504
Nitric Oxide Synthesis Is Reduced in Subjects With Type 2 Diabetes and Nephropathy
Paolo Tessari; Diego Cecchet; Alessandra Cosma; Monica Vettore; Anna Coracina; Renato Millioni; Elisabetta Iori; Lucia Puricelli; Angelo Avogaro; Monica Vedovato
Topics:
arginine
,
diabetes mellitus, type 2
,
insulin
,
kidney diseases
,
nitric oxide
Diabetes May 2010, Vol.59, 2152-2159. doi:https://doi.org/10.2337/db09-1772
Glucose-Dependent Insulinotropic Polypeptide May Enhance Fatty Acid Re-esterification in Subcutaneous Abdominal Adipose Tissue in Lean Humans
Topics:
abdomen
,
adipose tissue
,
glucose
,
saline solutions
,
transluminal attenuation gradient
Diabetes June 2010, Vol.59, 2160-2163. doi:https://doi.org/10.2337/db10-0098
Obesity Studies
Short-Term Overfeeding May Induce Peripheral Insulin Resistance Without Altering Subcutaneous Adipose Tissue Macrophages in Humans
Charmaine S. Tam; Alexander Viardot; Karine Clément; Joan Tordjman; Katherine Tonks; Jerry R. Greenfield; Lesley V. Campbell; Dorit Samocha-Bonet; Leonie K. Heilbronn
Topics:
fat, subcutaneous
,
insulin resistance
,
macrophages
,
overnutrition
,
flow cytometry
Diabetes June 2010, Vol.59, 2164-2170. doi:https://doi.org/10.2337/db10-0162
Increased Brain Fatty Acid Uptake in Metabolic Syndrome
Anna Karmi; Patricia Iozzo; Antti Viljanen; Jussi Hirvonen; Barbara A. Fielding; Kirsi Virtanen; Vesa Oikonen; Jukka Kemppainen; Tapio Viljanen; Letizia Guiducci; Merja Haaparanta-Solin; Kjell Någren; Olof Solin; Pirjo Nuutila
Topics:
brain
,
fatty acids
,
palmitates
,
positron-emission tomography
,
metabolic syndrome x
Diabetes June 2010, Vol.59, 2171-2177. doi:https://doi.org/10.2337/db09-0138
Islet Studies
β-Cell Failure in Diet-Induced Obese Mice Stratified According to Body Weight Gain: Secretory Dysfunction and Altered Islet Lipid Metabolism Without Steatosis or Reduced β-Cell Mass
Marie-Line Peyot; Emilie Pepin; Julien Lamontagne; Martin G. Latour; Bader Zarrouki; Roxane Lussier; Marco Pineda; Thomas L. Jetton; S.R. Murthy Madiraju; Erik Joly; Marc Prentki
Topics:
diet
,
gata3 gene
,
glucose
,
homologous recombinational dna repair
,
insulin
Diabetes June 2010, Vol.59, 2178-2187. doi:https://doi.org/10.2337/db09-1452
Elimination of Negative Feedback Control Mechanisms Along the Insulin Signaling Pathway Improves β-Cell Function Under Stress
Diana Gurevitch; Sigalit Boura-Halfon; Roi Isaac; Galit Shahaf; Moti Alberstein; Denise Ronen; Eli C. Lewis; Yehiel Zick
Topics:
adenoviruses
,
cytokine
,
glucose
,
infections
,
insulin
Diabetes June 2010, Vol.59, 2188-2197. doi:https://doi.org/10.2337/db09-0890
Membrane Potential-Dependent Inactivation of Voltage-Gated Ion Channels in α-Cells Inhibits Glucagon Secretion From Human Islets
Reshma Ramracheya; Caroline Ward; Makoto Shigeto; Jonathan N. Walker; Stefan Amisten; Quan Zhang; Paul R. Johnson; Patrik Rorsman; Matthias Braun
Topics:
glucagon secretion
,
glucose
,
ion channels
,
tissue membrane
,
depolarization
Diabetes June 2010, Vol.59, 2198-2208. doi:https://doi.org/10.2337/db09-1505
Targeted Disruption of Pancreatic-Derived Factor (PANDER, FAM3B) Impairs Pancreatic β-Cell Function
Claudia E. Robert-Cooperman; Jason R. Carnegie; Camella G. Wilson; Jichun Yang; Joshua R. Cook; Jianmei Wu; Robert A. Young; Bryan A. Wolf; Brant R. Burkhardt
Diabetes June 2010, Vol.59, 2209-2218. doi:https://doi.org/10.2337/db09-1552
Immunology and Transplantation
Local Expression of Indoleamine 2,3 Dioxygenase in Syngeneic Fibroblasts Significantly Prolongs Survival of an Engineered Three-Dimensional Islet Allograft
Reza B. Jalili; Farshad Forouzandeh; Alireza Moeen Rezakhanlou; Ryan Hartwell; Abelardo Medina; Garth L. Warnock; Bagher Larijani; Aziz Ghahary
Topics:
allografting
,
composite graft
,
fibroblasts
,
mice
,
tissue transplants
Diabetes June 2010, Vol.59, 2219-2227. doi:https://doi.org/10.2337/db09-1560
Induction of Chimerism Permits Low-Dose Islet Grafts in the Liver or Pancreas to Reverse Refractory Autoimmune Diabetes
Chunyan Zhang; Miao Wang; Jeremy J. Racine; Hongjun Liu; Chia-Lei Lin; Indu Nair; Joyce Lau; Yu-An Cao; Ivan Todorov; Mark Atkinson; Defu Zeng
Topics:
chimerism
,
donors
,
liver
,
pancreas
,
tissue transplants
Diabetes June 2010, Vol.59, 2228-2236. doi:https://doi.org/10.2337/db10-0450
Inflammatory Tendencies and Overproduction of IL-17 in the Colon of Young NOD Mice Are Counteracted With Diet Change
Topics:
colon
,
lamina propria
,
mice, inbred nod
,
diet
,
mice
Diabetes June 2010, Vol.59, 2237-2246. doi:https://doi.org/10.2337/db10-0147
Immune Cell–Derived C3 Is Required for Autoimmune Diabetes Induced by Multiple Low Doses of Streptozotocin
Marvin Lin; Na Yin; Barbara Murphy; M. Edward Medof; Stephan Segerer; Peter S. Heeger; Bernd Schröppel
Topics:
autoimmunity
,
mice
,
streptozocin
,
t-lymphocytes
,
bone marrow
Diabetes June 2010, Vol.59, 2247-2252. doi:https://doi.org/10.2337/db10-0044
A Novel Clinically Relevant Strategy to Abrogate Autoimmunity and Regulate Alloimmunity in NOD Mice
Andrea Vergani; Francesca D'Addio; Mollie Jurewicz; Alessandra Petrelli; Toshihiko Watanabe; Kaifeng Liu; Kenneth Law; Christian Schuetz; Michele Carvello; Elena Orsenigo; Shaoping Deng; Scott J. Rodig; Javeed M. Ansari; Carlo Staudacher; Reza Abdi; John Williams; James Markmann; Mark Atkinson; Mohamed H. Sayegh; Paolo Fiorina
Topics:
immunoglobulins
,
mice, inbred nod
,
mice
,
autoimmunity
Diabetes September 2010, Vol.59, 2253-2264. doi:https://doi.org/10.2337/db09-1264
Human Immune System Development and Rejection of Human Islet Allografts in Spontaneously Diabetic NOD-Rag1null IL2rγnull Ins2Akita Mice
Michael A. Brehm; Rita Bortell; Philip diIorio; Jean Leif; Joseph Laning; Amy Cuthbert; Chaoxing Yang; Mary Herlihy; Lisa Burzenski; Bruce Gott; Oded Foreman; Alvin C. Powers; Dale L. Greiner; Leonard D. Shultz
Topics:
mice
,
transplantation
,
allografting
,
hyperglycemia
,
interleukin 2 receptor
Diabetes June 2010, Vol.59, 2265-2270. doi:https://doi.org/10.2337/db10-0323
Pathophysiology
Brain Insulin Action Regulates Hypothalamic Glucose Sensing and the Counterregulatory Response to Hypoglycemia
Kelly A. Diggs-Andrews; Xuezhao Zhang; Zhentao Song; Dorit Daphna-Iken; Vanessa H. Routh; Simon J. Fisher
Topics:
brain
,
glucose
,
hypoglycemia
,
hypothalamus
,
insulin
Diabetes June 2010, Vol.59, 2271-2280. doi:https://doi.org/10.2337/db10-0401
Age-Period-Cohort Analysis of 1990–2003 Incidence Time Trends of Childhood Diabetes in Italy: The RIDI Study
Graziella Bruno; Milena Maule; Franco Merletti; Giulia Novelli; Alberto Falorni; Antonio Iannilli; Lorenzo Iughetti; Emma Altobelli; Giuseppe d'Annunzio; Silvano Piffer; Paolo Pozzilli; Dario Iafusco; Marco Songini; Federico Roncarolo; Sonia Toni; Flavia Carle; Valentino Cherubini; the RIDI Study Group
Topics:
child
,
diabetes mellitus, type 1
,
italy
,
age groups
Diabetes June 2010, Vol.59, 2281-2287. doi:https://doi.org/10.2337/db10-0151
Cellularity and Adipogenic Profile of the Abdominal Subcutaneous Adipose Tissue From Obese Adolescents: Association With Insulin Resistance and Hepatic Steatosis
Romy Kursawe; Markus Eszlinger; Deepak Narayan; Teresa Liu; Merlijn Bazuine; Anna M.G. Cali; Ebe D'Adamo; Melissa Shaw; Bridget Pierpont; Gerald I. Shulman; Samuel W. Cushman; Arthur Sherman; Sonia Caprio
Topics:
abdomen
,
adipocytes
,
adolescent
,
body fat distribution
,
cell size
Diabetes September 2010, Vol.59, 2288-2296. doi:https://doi.org/10.2337/db10-0113
Complications
Müller Cell-Derived VEGF Is Essential for Diabetes-Induced Retinal Inflammation and Vascular Leakage
Topics:
mice
,
vascular endothelial growth factor a
,
retinitis
,
retina
,
immunoblotting
Diabetes June 2010, Vol.59, 2297-2305. doi:https://doi.org/10.2337/db09-1420
The Redox Enzyme p66Shc Contributes to Diabetes and Ischemia-Induced Delay in Cutaneous Wound Healing
Gian Paolo Fadini; Mattia Albiero; Lisa Menegazzo; Elisa Boscaro; Elisa Pagnin; Elisabetta Iori; Chiara Cosma; Annunziata Lapolla; Vittorio Pengo; Massimo Stendardo; Carlo Agostini; Pier Giuseppe Pelicci; Marco Giorgio; Angelo Avogaro
Topics:
ischemia
,
mice
,
wound healing
,
enzymes
,
glucose
Diabetes June 2010, Vol.59, 2306-2314. doi:https://doi.org/10.2337/db09-1727
Improvement of Retinal Vascular Injury in Diabetic Rats by Statins Is Associated With the Inhibition of Mitochondrial Reactive Oxygen Species Pathway Mediated by Peroxisome Proliferator–Activated Receptor γ Coactivator 1α
Zhi Zheng; Haibing Chen; Hong Wang; Bilian Ke; Bingqing Zheng; Qian Li; Peiyu Li; Li Su; Qing Gu; Xun Xu
Topics:
mitochondria
,
mitogen-activated protein kinase p38
,
poly(adp-ribose) polymerases
,
rats
,
simvastatin
Diabetes June 2010, Vol.59, 2315-2325. doi:https://doi.org/10.2337/db10-0638
Genetics
Homozygous Mutations in NEUROD1 Are Responsible for a Novel Syndrome of Permanent Neonatal Diabetes and Neurological Abnormalities
Oscar Rubio-Cabezas; Jayne A.L. Minton; Iren Kantor; Denise Williams; Sian Ellard; Andrew T. Hattersley
Topics:
homozygote
,
mutation
,
neonatal diabetes mellitus
,
genes
,
congenital cerebellar hypoplasia
Diabetes June 2010, Vol.59, 2326-2331. doi:https://doi.org/10.2337/db10-0011
Online Letters to the Editor
Comment on: Robertson (2010) Islet Transplantation a Decade Later and Strategies for Filling a Half-Full Glass. Diabetes;59:1285–1291
Topics:
glass
,
islets of langerhans transplantation
Diabetes September 2010, Vol.59, e13. doi:https://doi.org/10.2337/db10-0848
Response to Comment on: Robertson (2010) Islet Transplantation a Decade Later and Strategies for Filling a Half-Full Glass. Diabetes;59:1285–1291
Topics:
glass
,
islets of langerhans transplantation
Diabetes September 2010, Vol.59, e14. doi:https://doi.org/10.2337/db10-0881
Comment on: Chauhan et al. (2010) Impact of Common Variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the Risk of Type 2 Diabetes in 5,164 Indians. Diabetes;59:2068–2074
Topics:
diabetes mellitus, type 2
,
genes, p16
,
kcnj11 gene
,
protein p16
,
slc30a8 gene
Diabetes September 2010, Vol.59, e15. doi:https://doi.org/10.2337/db10-0748
Response to Comment on: Chauhan et al. (2010) Impact of Common Variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the Risk of Type 2 Diabetes in 5,164 Indians. Diabetes;59:2068–2074
Ganesh Chauhan; Charles J. Spurgeon; Rubina Tabassum; Seema Bhaskar; Smita R. Kulkarni; Anubha Mahajan; Sreenivas Chavali; M.V. Kranthi Kumar; Swami Prakash; Om Prakash Dwivedi; Saurabh Ghosh; Chittaranjan S. Yajnik; Nikhil Tandon; Dwaipayan Bharadwaj; Giriraj R. Chandak
Topics:
diabetes mellitus, type 2
,
genes, p16
,
kcnj11 gene
,
protein p16
,
slc30a8 gene
Diabetes September 2010, Vol.59, e16. doi:https://doi.org/10.2337/db10-0868
Comment on: Yang et al. (2010) Associations of Hyperglycemia and Insulin Usage With the Risk of Cancer in Type 2 Diabetes: The Hong Kong Diabetes Registry. Diabetes;59:1254–1260
Topics:
diabetes mellitus, type 2
,
hyperglycemia
,
insulin
,
cancer risk
,
follow-up
Diabetes September 2010, Vol.59, e17-e18. doi:https://doi.org/10.2337/db10-0777
Response to Comment on: Yang et al. (2010) Associations of Hyperglycemia and Insulin Usage With the Risk of Cancer in Type 2 Diabetes: The Hong Kong Diabetes Registry. Diabetes;59:1254–1260
Topics:
cancer
,
diabetes mellitus, type 2
,
hyperglycemia
,
insulin
,
sensitivity analysis
Diabetes September 2010, Vol.59, e19-e22. doi:https://doi.org/10.2337/db10-0859
Comment on: Matsuoka et al. (2010) Regulation of MafA Expression in Pancreatic β-Cells in db/db Mice With Diabetes. Diabetes;59:1709–1720
Diabetes September 2010, Vol.59, e23. doi:https://doi.org/10.2337/db10-0684
