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Issues
Perspectives in Diabetes
Stopping Type 1 Diabetes: Attempts to Prevent or Cure Type 1 Diabetes in Man
Diabetes January 2011, Vol.60, 1-8. doi:https://doi.org/10.2337/db10-1114
Toward a More Complete (and Less Controversial) Understanding of Energy Expenditure and Its Role in Obesity Pathogenesis
Diabetes January 2011, Vol.60, 17-23. doi:https://doi.org/10.2337/db10-0909
Commentaries
Elimination of Hypoglycemia From the Lives of People Affected by Diabetes
Diabetes January 2011, Vol.60, 24-27. doi:https://doi.org/10.2337/db10-1359
Metabolism
Enhanced Energy Expenditure, Glucose Utilization, and Insulin Sensitivity in VAMP8 Null Mice
Haihong Zong; Cheng-Chun Wang; Bhavapriya Vaitheesvaran; Irwin J. Kurland; Wanjin Hong; Jeffrey E. Pessin
Diabetes September 2010, Vol.60, 30-38. doi:https://doi.org/10.2337/db10-0231
Downregulation of Adipose Tissue Fatty Acid Trafficking in Obesity: A Driver for Ectopic Fat Deposition?
Siobhán E. McQuaid; Leanne Hodson; Matthew J. Neville; A. Louise Dennis; Jane Cheeseman; Sandy M. Humphreys; Toralph Ruge; Marjorie Gilbert; Barbara A. Fielding; Keith N. Frayn; Fredrik Karpe
Diabetes October 2010, Vol.60, 47-55. doi:https://doi.org/10.2337/db10-0867
The Portal Theory Supported by Venous Drainage–Selective Fat Transplantation
Diabetes October 2010, Vol.60, 56-63. doi:https://doi.org/10.2337/db10-0697
Lipid-Induced Insulin Resistance Affects Women Less Than Men and Is Not Accompanied by Inflammation or Impaired Proximal Insulin Signaling
Louise D. Høeg; Kim A. Sjøberg; Jacob Jeppesen; Thomas E. Jensen; Christian Frøsig; Jesper B. Birk; Bruno Bisiani; Natalie Hiscock; Henriette Pilegaard; Jørgen F.P. Wojtaszewski; Erik A. Richter; Bente Kiens
Diabetes October 2010, Vol.60, 64-73. doi:https://doi.org/10.2337/db10-0698
Changes in Alcohol Consumption and Subsequent Risk of Type 2 Diabetes in Men
Michel M. Joosten; Stephanie E. Chiuve; Kenneth J. Mukamal; Frank B. Hu; Henk F.J. Hendriks; Eric B. Rimm
Diabetes September 2010, Vol.60, 74-79. doi:https://doi.org/10.2337/db10-1052
Iron Overload and Diabetes Risk: A Shift From Glucose to Fatty Acid Oxidation and Increased Hepatic Glucose Production in a Mouse Model of Hereditary Hemochromatosis
Jingyu Huang; Deborah Jones; Bai Luo; Michael Sanderson; Jamie Soto; E. Dale Abel; Robert C. Cooksey; Donald A. McClain
Diabetes September 2010, Vol.60, 80-87. doi:https://doi.org/10.2337/db10-0593
Basal and Insulin Mediated VLDL-Triglyceride Kinetics in Type 2 Diabetic Men
Lars P. Sørensen; Iben R. Andersen; Esben Søndergaard; Lars C. Gormsen; Ole Schmitz; Jens S. Christiansen; Søren Nielsen
Diabetes September 2010, Vol.60, 88-96. doi:https://doi.org/10.2337/db10-0564
Molecular Mechanisms for Activation of the Agouti-Related Protein and Stimulation of Appetite
Olha Ilnytska; Adrian M. Stütz; MieJung Park-York; David A. York; David M. Ribnicky; Aamir Zuberi; William T. Cefalu; George Argyropoulos
Diabetes October 2010, Vol.60, 97-106. doi:https://doi.org/10.2337/db10-0172
Hypothalamic Nutrient Sensing Activates a Forebrain-Hindbrain Neuronal Circuit to Regulate Glucose Production In Vivo
Diabetes September 2010, Vol.60, 107-113. doi:https://doi.org/10.2337/db10-0994
Intranasal Insulin Enhances Postprandial Thermogenesis and Lowers Postprandial Serum Insulin Levels in Healthy Men
Christian Benedict; Swantje Brede; Helgi B. Schiöth; Hendrik Lehnert; Bernd Schultes; Jan Born; Manfred Hallschmid
Diabetes September 2010, Vol.60, 114-118. doi:https://doi.org/10.2337/db10-0329
Signal Transduction
Lack of TRPM2 Impaired Insulin Secretion and Glucose Metabolisms in Mice
Kunitoshi Uchida; Katsuya Dezaki; Boldbaatar Damdindorj; Hitoshi Inada; Tetsuya Shiuchi; Yasuo Mori; Toshihiko Yada; Yasuhiko Minokoshi; Makoto Tominaga
Diabetes October 2010, Vol.60, 119-126. doi:https://doi.org/10.2337/db10-0276
Direct Recruitment of Insulin Receptor and ERK Signaling Cascade to Insulin-Inducible Gene Loci
Diabetes October 2010, Vol.60, 127-137. doi:https://doi.org/10.2337/db09-1806
Prep1 Controls Insulin Glucoregulatory Function in Liver by Transcriptional Targeting of SHP1 Tyrosine Phosphatase
Francesco Oriente; Salvatore Iovino; Serena Cabaro; Angela Cassese; Elena Longobardi; Claudia Miele; Paola Ungaro; Pietro Formisano; Francesco Blasi; Francesco Beguinot
Diabetes September 2010, Vol.60, 138-147. doi:https://doi.org/10.2337/db10-0860
Cyclic GMP Kinase I Modulates Glucagon Release From Pancreatic α-Cells
Diabetes October 2010, Vol.60, 148-156. doi:https://doi.org/10.2337/db10-0595
Obesity Studies
OCT1 Expression in Adipocytes Could Contribute to Increased Metformin Action in Obese Subjects
José María Moreno-Navarrete; Francisco J. Ortega; José-Ignacio Rodríguez-Hermosa; Mònica Sabater; Gerard Pardo; Wifredo Ricart; José Manuel Fernández-Real
Diabetes October 2010, Vol.60, 168-176. doi:https://doi.org/10.2337/db10-0805
Nuclear Orphan Receptor TAK1/TR4-Deficient Mice Are Protected Against Obesity-Linked Inflammation, Hepatic Steatosis, and Insulin Resistance
Hong Soon Kang; Kyoko Okamoto; Yong-Sik Kim; Yukimasa Takeda; Carl D. Bortner; Huaixin Dang; Taira Wada; Wen Xie; Xiao-Ping Yang; Grace Liao; Anton M. Jetten
Diabetes September 2010, Vol.60, 177-188. doi:https://doi.org/10.2337/db10-0628
P-Selectin Glycoprotein Ligand-1 Deficiency Is Protective Against Obesity-Related Insulin Resistance
Chikage Sato; Kenichi Shikata; Daisho Hirota; Motofumi Sasaki; Shingo Nishishita; Satoshi Miyamoto; Ryo Kodera; Daisuke Ogawa; Atsuhito Tone; Hitomi Usui Kataoka; Jun Wada; Nobuo Kajitani; Hirofumi Makino
Diabetes October 2010, Vol.60, 189-199. doi:https://doi.org/10.2337/db09-1894
Islet Studies
Peroxisome-Generated Hydrogen Peroxide as Important Mediator of Lipotoxicity in Insulin-Producing Cells
Diabetes October 2010, Vol.60, 200-208. doi:https://doi.org/10.2337/db09-1401
Congenital Hyperinsulinism and Glucose Hypersensitivity in Homozygous and Heterozygous Carriers of Kir6.2 (KCNJ11) Mutation V290M Mutation: KATP Channel Inactivation Mechanism and Clinical Management
Karen J. Loechner; Alejandro Akrouh; Harley T. Kurata; Carlo Dionisi-Vici; Arianna Maiorana; Milena Pizzoferro; Vittoria Rufini; Jean de Ville de Goyet; Carlo Colombo; Fabrizio Barbetti; Joseph C. Koster; Colin G. Nichols
Diabetes October 2010, Vol.60, 209-217. doi:https://doi.org/10.2337/db10-0731
Exendin-4 Suppresses Src Activation and Reactive Oxygen Species Production in Diabetic Goto-Kakizaki Rat Islets in an Epac-Dependent Manner
Eri Mukai; Shimpei Fujimoto; Hiroki Sato; Chitose Oneyama; Rieko Kominato; Yuichi Sato; Mayumi Sasaki; Yuichi Nishi; Masato Okada; Nobuya Inagaki
Diabetes October 2010, Vol.60, 218-226. doi:https://doi.org/10.2337/db10-0021
β-Cell Dysfunctional ERAD/Ubiquitin/Proteasome System in Type 2 Diabetes Mediated by Islet Amyloid Polypeptide–Induced UCH-L1 Deficiency
Safia Costes; Chang-jiang Huang; Tatyana Gurlo; Marie Daval; Aleksey V. Matveyenko; Robert A. Rizza; Alexandra E. Butler; Peter C. Butler
Diabetes October 2010, Vol.60, 227-238. doi:https://doi.org/10.2337/db10-0522
Immunology and Transplantation
Production of Functional Glucagon-Secreting α-Cells From Human Embryonic Stem Cells
Alireza Rezania; Michael J. Riedel; Rhonda D. Wideman; Francis Karanu; Ziliang Ao; Garth L. Warnock; Timothy J. Kieffer
Diabetes October 2010, Vol.60, 239-247. doi:https://doi.org/10.2337/db10-0573
Interleukin-1β Produced in Response to Islet Autoantigen Presentation Differentiates T-Helper 17 Cells at the Expense of Regulatory T-Cells: Implications for the Timing of Tolerizing Immunotherapy
Sebastien Bertin-Maghit; Dimeng Pang; Brendan O'Sullivan; Shannon Best; Emily Duggan; Sanjoy Paul; Helen Thomas; Thomas W.H. Kay; Leonard C. Harrison; Raymond Steptoe; Ranjeny Thomas
Diabetes October 2010, Vol.60, 248-257. doi:https://doi.org/10.2337/db10-0104
Pathophysiology
FTO Is Increased in Muscle During Type 2 Diabetes, and Its Overexpression in Myotubes Alters Insulin Signaling, Enhances Lipogenesis and ROS Production, and Induces Mitochondrial Dysfunction
Amélie Bravard; Etienne Lefai; Emmanuelle Meugnier; Sandra Pesenti; Emmanuel Disse; Julien Vouillarmet; Nöel Peretti; Rémi Rabasa-Lhoret; Martine Laville; Hubert Vidal; Jennifer Rieusset
Diabetes October 2010, Vol.60, 258-268. doi:https://doi.org/10.2337/db10-0281
Coffee and Caffeine Consumption in Relation to Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes in Postmenopausal Women
Diabetes October 2010, Vol.60, 269-275. doi:https://doi.org/10.2337/db10-1193
Enterovirus RNA in Blood Is Linked to the Development of Type 1 Diabetes
Sami Oikarinen; Mika Martiskainen; Sisko Tauriainen; Heini Huhtala; Jorma Ilonen; Riitta Veijola; Olli Simell; Mikael Knip; Heikki Hyöty
Diabetes October 2010, Vol.60, 276-279. doi:https://doi.org/10.2337/db10-0186
Complications
miR-200a Prevents Renal Fibrogenesis Through Repression of TGF-β2 Expression
Bo Wang; Philip Koh; Catherine Winbanks; Melinda T. Coughlan; Aaron McClelland; Anna Watson; Karin Jandeleit-Dahm; Wendy C. Burns; Merlin C. Thomas; Mark E. Cooper; Phillip Kantharidis
Diabetes October 2010, Vol.60, 280-287. doi:https://doi.org/10.2337/db10-0892
Diminished Superoxide Generation Is Associated With Respiratory Chain Dysfunction and Changes in the Mitochondrial Proteome of Sensory Neurons From Diabetic Rats
Eli Akude; Elena Zherebitskaya; Subir K. Roy Chowdhury; Darrell R. Smith; Rick T. Dobrowsky; Paul Fernyhough
Diabetes September 2010, Vol.60, 288-297. doi:https://doi.org/10.2337/db10-0818
Glycated Hemoglobin and the Risk of Kidney Disease and Retinopathy in Adults With and Without Diabetes
Elizabeth Selvin; Yang Ning; Michael W. Steffes; Lori D. Bash; Ronald Klein; Tien Y. Wong; Brad C. Astor; A. Richey Sharrett; Frederick L. Brancati; Josef Coresh
Diabetes October 2010, Vol.60, 298-305. doi:https://doi.org/10.2337/db10-1198
Insulin Resistance, Defective Insulin-Mediated Fatty Acid Suppression, and Coronary Artery Calcification in Subjects With and Without Type 1 Diabetes: The CACTI Study
Irene E. Schauer; Janet K. Snell-Bergeon; Bryan C. Bergman; David M. Maahs; Adam Kretowski; Robert H. Eckel; Marian Rewers
Diabetes October 2010, Vol.60, 306-314. doi:https://doi.org/10.2337/db10-0328
High Connectivity Between Reduced Cortical Thickness and Disrupted White Matter Tracts in Long-Standing Type 1 Diabetes
Daniel T. Franc; Christopher T. Kodl; Bryon A. Mueller; Ryan L. Muetzel; Kelvin O. Lim; Elizabeth R. Seaquist
Diabetes October 2010, Vol.60, 315-319. doi:https://doi.org/10.2337/db10-0598
Genetics
Targeted Inactivation of Kinesin-1 in Pancreatic β-Cells In Vivo Leads to Insulin Secretory Deficiency
Ju Cui; Zai Wang; Qianni Cheng; Raozhou Lin; Xin-Mei Zhang; Po Sing Leung; Neal G. Copeland; Nancy A. Jenkins; Kwok-Ming Yao; Jian-Dong Huang
Diabetes September 2010, Vol.60, 320-330. doi:https://doi.org/10.2337/db09-1078
Association of a Fasting Glucose Genetic Risk Score With Subclinical Atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) Study
Laura J. Rasmussen-Torvik; Man Li; Wen H. Kao; David Couper; Eric Boerwinkle; Suzette J. Bielinski; Aaron R. Folsom; James S. Pankow
Diabetes October 2010, Vol.60, 331-335. doi:https://doi.org/10.2337/db10-0839
Both Polymorphic Variable Number of Tandem Repeats and Autoimmune Regulator Modulate Differential Expression of Insulin in Human Thymic Epithelial Cells
Diabetes September 2010, Vol.60, 336-344. doi:https://doi.org/10.2337/db10-0255
Genetic Predisposition to Long-Term Nondiabetic Deteriorations in Glucose Homeostasis: Ten-Year Follow-Up of the GLACIER Study
Frida Renström; Dmitry Shungin; Ingegerd Johansson; the MAGIC Investigators; Jose C. Florez; Göran Hallmans; Frank B. Hu; Paul W. Franks
Diabetes September 2010, Vol.60, 345-354. doi:https://doi.org/10.2337/db10-0933
mt-Nd2a Modifies Resistance Against Autoimmune Type 1 Diabetes in NOD Mice at the Level of the Pancreatic β-Cell
Diabetes October 2010, Vol.60, 355-359. doi:https://doi.org/10.2337/db10-1241
Erratum
Online Letters to the Editor
Response to Comment on: Kaiyala et al. (2010) Identification of Body Fat Mass as a Major Determinant of Metabolic Rate in Mice. Diabetes;59:1657–1666
Karl J. Kaiyala; Gregory J. Morton; Brian G. Leroux; Kayoko Ogimoto; Brent Wisse; Michael W. Schwartz
Diabetes January 2011, Vol.60, e4. doi:https://doi.org/10.2337/db10-1445