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Issues
Perspectives in Diabetes
Stopping Type 1 Diabetes: Attempts to Prevent or Cure Type 1 Diabetes in Man
Topics:
diabetes mellitus, type 1
Diabetes January 2011, Vol.60, 1-8. doi:https://doi.org/10.2337/db10-1114
Diabetic Retinopathy: Targeting Vasoregression
Topics:
blood capillaries
,
diabetic retinopathy
,
endothelial cells
,
hyperglycemia
,
pericytes
Diabetes January 2011, Vol.60, 9-16. doi:https://doi.org/10.2337/db10-0454
Toward a More Complete (and Less Controversial) Understanding of Energy Expenditure and Its Role in Obesity Pathogenesis
Topics:
obesity
,
mice
,
calorimetry, indirect
Diabetes January 2011, Vol.60, 17-23. doi:https://doi.org/10.2337/db10-0909
Commentaries
Elimination of Hypoglycemia From the Lives of People Affected by Diabetes
Topics:
hypoglycemia
,
glucose
,
diabetes mellitus, type 1
,
insulin
Diabetes January 2011, Vol.60, 24-27. doi:https://doi.org/10.2337/db10-1359
TRP-ing Down the Path to Insulin Secretion
Topics:
clusterin
,
glucose
,
insulin secretion
,
glucagon-like peptide 1
,
depolarization
Diabetes January 2011, Vol.60, 28-29. doi:https://doi.org/10.2337/db10-1402
Metabolism
Enhanced Energy Expenditure, Glucose Utilization, and Insulin Sensitivity in VAMP8 Null Mice
Haihong Zong; Cheng-Chun Wang; Bhavapriya Vaitheesvaran; Irwin J. Kurland; Wanjin Hong; Jeffrey E. Pessin
Topics:
energy metabolism
,
glucose
,
insulin
,
insulin sensitivity
,
mice
Diabetes September 2010, Vol.60, 30-38. doi:https://doi.org/10.2337/db10-0231
Naloxone, but Not Valsartan, Preserves Responses to Hypoglycemia After Antecedent Hypoglycemia: Role of Metabolic Reprogramming in Counterregulatory Failure
Topics:
hypoglycemia
,
naloxone
,
valsartan
Diabetes September 2010, Vol.60, 39-46. doi:https://doi.org/10.2337/db10-0326
Downregulation of Adipose Tissue Fatty Acid Trafficking in Obesity: A Driver for Ectopic Fat Deposition?
Siobhán E. McQuaid; Leanne Hodson; Matthew J. Neville; A. Louise Dennis; Jane Cheeseman; Sandy M. Humphreys; Toralph Ruge; Marjorie Gilbert; Barbara A. Fielding; Keith N. Frayn; Fredrik Karpe
Topics:
adipose tissue
,
fatty acids
,
nonesterified fatty acids
,
obesity
,
insulin
Diabetes October 2010, Vol.60, 47-55. doi:https://doi.org/10.2337/db10-0867
The Portal Theory Supported by Venous Drainage–Selective Fat Transplantation
Topics:
blood outflow
,
epididymis
,
fat pad
,
fat transplantation
,
insulin
Diabetes October 2010, Vol.60, 56-63. doi:https://doi.org/10.2337/db10-0697
Lipid-Induced Insulin Resistance Affects Women Less Than Men and Is Not Accompanied by Inflammation or Impaired Proximal Insulin Signaling
Louise D. Høeg; Kim A. Sjøberg; Jacob Jeppesen; Thomas E. Jensen; Christian Frøsig; Jesper B. Birk; Bruno Bisiani; Natalie Hiscock; Henriette Pilegaard; Jørgen F.P. Wojtaszewski; Erik A. Richter; Bente Kiens
Topics:
glucose
,
infusion procedures
,
insulin
,
insulin resistance
,
intravenous fat emulsions
Diabetes October 2010, Vol.60, 64-73. doi:https://doi.org/10.2337/db10-0698
Changes in Alcohol Consumption and Subsequent Risk of Type 2 Diabetes in Men
Michel M. Joosten; Stephanie E. Chiuve; Kenneth J. Mukamal; Frank B. Hu; Henk F.J. Hendriks; Eric B. Rimm
Topics:
alcohol drinking
,
diabetes mellitus, type 2
Diabetes September 2010, Vol.60, 74-79. doi:https://doi.org/10.2337/db10-1052
Iron Overload and Diabetes Risk: A Shift From Glucose to Fatty Acid Oxidation and Increased Hepatic Glucose Production in a Mouse Model of Hereditary Hemochromatosis
Jingyu Huang; Deborah Jones; Bai Luo; Michael Sanderson; Jamie Soto; E. Dale Abel; Robert C. Cooksey; Donald A. McClain
Topics:
fatty acid oxidation
,
glucose
,
mice
,
oxidation
,
skeletal muscles
Diabetes September 2010, Vol.60, 80-87. doi:https://doi.org/10.2337/db10-0593
Basal and Insulin Mediated VLDL-Triglyceride Kinetics in Type 2 Diabetic Men
Lars P. Sørensen; Iben R. Andersen; Esben Søndergaard; Lars C. Gormsen; Ole Schmitz; Jens S. Christiansen; Søren Nielsen
Topics:
lipoproteins, vldl
,
insulin
Diabetes September 2010, Vol.60, 88-96. doi:https://doi.org/10.2337/db10-0564
Molecular Mechanisms for Activation of the Agouti-Related Protein and Stimulation of Appetite
Olha Ilnytska; Adrian M. Stütz; MieJung Park-York; David A. York; David M. Ribnicky; Aamir Zuberi; William T. Cefalu; George Argyropoulos
Topics:
agouti-related protein
,
mice
Diabetes October 2010, Vol.60, 97-106. doi:https://doi.org/10.2337/db10-0172
Hypothalamic Nutrient Sensing Activates a Forebrain-Hindbrain Neuronal Circuit to Regulate Glucose Production In Vivo
Topics:
glucose
,
hypothalamus
,
n-methyl-d-aspartate receptors
,
infusion procedures
,
ampk
Diabetes September 2010, Vol.60, 107-113. doi:https://doi.org/10.2337/db10-0994
Intranasal Insulin Enhances Postprandial Thermogenesis and Lowers Postprandial Serum Insulin Levels in Healthy Men
Christian Benedict; Swantje Brede; Helgi B. Schiöth; Hendrik Lehnert; Bernd Schultes; Jan Born; Manfred Hallschmid
Topics:
insulin
,
postprandial period
,
thermogenesis
,
insulin administration
,
plasma glucose
Diabetes September 2010, Vol.60, 114-118. doi:https://doi.org/10.2337/db10-0329
Signal Transduction
Lack of TRPM2 Impaired Insulin Secretion and Glucose Metabolisms in Mice
Kunitoshi Uchida; Katsuya Dezaki; Boldbaatar Damdindorj; Hitoshi Inada; Tetsuya Shiuchi; Yasuo Mori; Toshihiko Yada; Yasuhiko Minokoshi; Makoto Tominaga
Topics:
clusterin
,
glucose
,
insulin
,
mice
,
insulin secretion
Diabetes October 2010, Vol.60, 119-126. doi:https://doi.org/10.2337/db10-0276
Direct Recruitment of Insulin Receptor and ERK Signaling Cascade to Insulin-Inducible Gene Loci
Topics:
genes
,
glucose
,
insulin
,
mice
,
mitogen-activated protein kinases
Diabetes October 2010, Vol.60, 127-137. doi:https://doi.org/10.2337/db09-1806
Prep1 Controls Insulin Glucoregulatory Function in Liver by Transcriptional Targeting of SHP1 Tyrosine Phosphatase
Francesco Oriente; Salvatore Iovino; Serena Cabaro; Angela Cassese; Elena Longobardi; Claudia Miele; Paola Ungaro; Pietro Formisano; Francesco Blasi; Francesco Beguinot
Topics:
hematopoietic cell phosphatase
,
insulin
,
liver
,
mice
,
glycogen
Diabetes September 2010, Vol.60, 138-147. doi:https://doi.org/10.2337/db10-0860
Cyclic GMP Kinase I Modulates Glucagon Release From Pancreatic α-Cells
Topics:
cyclic gmp
,
glucagon
,
glucose
,
insulin
,
mice
Diabetes October 2010, Vol.60, 148-156. doi:https://doi.org/10.2337/db10-0595
Obesity Studies
Mitochondrial Biogenesis and Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α (PGC-1α) Deacetylation by Physical Activity: Intact Adipocytokine Signaling Is Required
Topics:
adiponectin
,
leptin
,
mice
,
mitochondria
,
origin of life
Diabetes October 2010, Vol.60, 157-167. doi:https://doi.org/10.2337/db10-0331
OCT1 Expression in Adipocytes Could Contribute to Increased Metformin Action in Obese Subjects
José María Moreno-Navarrete; Francisco J. Ortega; José-Ignacio Rodríguez-Hermosa; Mònica Sabater; Gerard Pardo; Wifredo Ricart; José Manuel Fernández-Real
Topics:
adipocytes
,
metformin
,
obesity
,
gene expression
,
adipose tissue
Diabetes October 2010, Vol.60, 168-176. doi:https://doi.org/10.2337/db10-0805
Nuclear Orphan Receptor TAK1/TR4-Deficient Mice Are Protected Against Obesity-Linked Inflammation, Hepatic Steatosis, and Insulin Resistance
Hong Soon Kang; Kyoko Okamoto; Yong-Sik Kim; Yukimasa Takeda; Carl D. Bortner; Huaixin Dang; Taira Wada; Wen Xie; Xiao-Ping Yang; Grace Liao; Anton M. Jetten
Topics:
fatty liver
,
mice
,
obesity
,
inflammation
,
insulin resistance
Diabetes September 2010, Vol.60, 177-188. doi:https://doi.org/10.2337/db10-0628
P-Selectin Glycoprotein Ligand-1 Deficiency Is Protective Against Obesity-Related Insulin Resistance
Chikage Sato; Kenichi Shikata; Daisho Hirota; Motofumi Sasaki; Shingo Nishishita; Satoshi Miyamoto; Ryo Kodera; Daisuke Ogawa; Atsuhito Tone; Hitomi Usui Kataoka; Jun Wada; Nobuo Kajitani; Hirofumi Makino
Topics:
mice
,
obesity
,
p-selectin
,
insulin resistance
,
adipose tissue
Diabetes October 2010, Vol.60, 189-199. doi:https://doi.org/10.2337/db09-1894
Islet Studies
Peroxisome-Generated Hydrogen Peroxide as Important Mediator of Lipotoxicity in Insulin-Producing Cells
Topics:
catalase
,
hydrogen peroxide
,
insulin
,
palmitic acid
,
peroxisome
Diabetes October 2010, Vol.60, 200-208. doi:https://doi.org/10.2337/db09-1401
Congenital Hyperinsulinism and Glucose Hypersensitivity in Homozygous and Heterozygous Carriers of Kir6.2 (KCNJ11) Mutation V290M Mutation: KATP Channel Inactivation Mechanism and Clinical Management
Karen J. Loechner; Alejandro Akrouh; Harley T. Kurata; Carlo Dionisi-Vici; Arianna Maiorana; Milena Pizzoferro; Vittoria Rufini; Jean de Ville de Goyet; Carlo Colombo; Fabrizio Barbetti; Joseph C. Koster; Colin G. Nichols
Topics:
glucose
,
heterozygote
,
mutation
,
homozygote
,
proband
Diabetes October 2010, Vol.60, 209-217. doi:https://doi.org/10.2337/db10-0731
Exendin-4 Suppresses Src Activation and Reactive Oxygen Species Production in Diabetic Goto-Kakizaki Rat Islets in an Epac-Dependent Manner
Eri Mukai; Shimpei Fujimoto; Hiroki Sato; Chitose Oneyama; Rieko Kominato; Yuichi Sato; Mayumi Sasaki; Yuichi Nishi; Masato Okada; Nobuya Inagaki
Topics:
exenatide
,
glucose
,
immunoblotting
,
endocrine pancreas
Diabetes October 2010, Vol.60, 218-226. doi:https://doi.org/10.2337/db10-0021
β-Cell Dysfunctional ERAD/Ubiquitin/Proteasome System in Type 2 Diabetes Mediated by Islet Amyloid Polypeptide–Induced UCH-L1 Deficiency
Safia Costes; Chang-jiang Huang; Tatyana Gurlo; Marie Daval; Aleksey V. Matveyenko; Robert A. Rizza; Alexandra E. Butler; Peter C. Butler
Topics:
diabetes mellitus, type 2
,
iapp gene
,
insulin
,
multicatalytic endopeptidase complex
,
stress
Diabetes October 2010, Vol.60, 227-238. doi:https://doi.org/10.2337/db10-0522
Immunology and Transplantation
Production of Functional Glucagon-Secreting α-Cells From Human Embryonic Stem Cells
Alireza Rezania; Michael J. Riedel; Rhonda D. Wideman; Francis Karanu; Ziliang Ao; Garth L. Warnock; Timothy J. Kieffer
Topics:
glucagon
,
hetastarch
,
insulin
,
primary eosinophilic endomyocardial cardiomyopathy
,
transplantation
Diabetes October 2010, Vol.60, 239-247. doi:https://doi.org/10.2337/db10-0573
Interleukin-1β Produced in Response to Islet Autoantigen Presentation Differentiates T-Helper 17 Cells at the Expense of Regulatory T-Cells: Implications for the Timing of Tolerizing Immunotherapy
Sebastien Bertin-Maghit; Dimeng Pang; Brendan O'Sullivan; Shannon Best; Emily Duggan; Sanjoy Paul; Helen Thomas; Thomas W.H. Kay; Leonard C. Harrison; Raymond Steptoe; Ranjeny Thomas
Topics:
autoantigens
,
cytokine
,
interleukin-1
,
interleukin-17
,
mice
Diabetes October 2010, Vol.60, 248-257. doi:https://doi.org/10.2337/db10-0104
Pathophysiology
FTO Is Increased in Muscle During Type 2 Diabetes, and Its Overexpression in Myotubes Alters Insulin Signaling, Enhances Lipogenesis and ROS Production, and Induces Mitochondrial Dysfunction
Amélie Bravard; Etienne Lefai; Emmanuelle Meugnier; Sandra Pesenti; Emmanuel Disse; Julien Vouillarmet; Nöel Peretti; Rémi Rabasa-Lhoret; Martine Laville; Hubert Vidal; Jennifer Rieusset
Topics:
fto gene
,
insulin
,
protein overexpression
,
skeletal myocytes
,
diabetes mellitus, type 2
Diabetes October 2010, Vol.60, 258-268. doi:https://doi.org/10.2337/db10-0281
Coffee and Caffeine Consumption in Relation to Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes in Postmenopausal Women
Topics:
coffee
,
diabetes mellitus, type 2
,
sex hormone-binding globulin
,
plasma
,
gonadal steroid hormones
Diabetes October 2010, Vol.60, 269-275. doi:https://doi.org/10.2337/db10-1193
Enterovirus RNA in Blood Is Linked to the Development of Type 1 Diabetes
Sami Oikarinen; Mika Martiskainen; Sisko Tauriainen; Heini Huhtala; Jorma Ilonen; Riitta Veijola; Olli Simell; Mikael Knip; Heikki Hyöty
Topics:
autoantibodies
,
child
,
diabetes mellitus, type 1
,
enterovirus
,
rna
Diabetes October 2010, Vol.60, 276-279. doi:https://doi.org/10.2337/db10-0186
Complications
miR-200a Prevents Renal Fibrogenesis Through Repression of TGF-β2 Expression
Bo Wang; Philip Koh; Catherine Winbanks; Melinda T. Coughlan; Aaron McClelland; Anna Watson; Karin Jandeleit-Dahm; Wendy C. Burns; Merlin C. Thomas; Mark E. Cooper; Phillip Kantharidis
Topics:
fibrosis
,
kidney
,
kidney diseases
,
mice
,
micrornas
Diabetes October 2010, Vol.60, 280-287. doi:https://doi.org/10.2337/db10-0892
Diminished Superoxide Generation Is Associated With Respiratory Chain Dysfunction and Changes in the Mitochondrial Proteome of Sensory Neurons From Diabetic Rats
Eli Akude; Elena Zherebitskaya; Subir K. Roy Chowdhury; Darrell R. Smith; Rick T. Dobrowsky; Paul Fernyhough
Topics:
ganglia, spinal
,
insulin
,
mitochondria
,
neurons
,
neurons, afferent
Diabetes September 2010, Vol.60, 288-297. doi:https://doi.org/10.2337/db10-0818
Glycated Hemoglobin and the Risk of Kidney Disease and Retinopathy in Adults With and Without Diabetes
Elizabeth Selvin; Yang Ning; Michael W. Steffes; Lori D. Bash; Ronald Klein; Tien Y. Wong; Brad C. Astor; A. Richey Sharrett; Frederick L. Brancati; Josef Coresh
Topics:
hemoglobin
,
kidney diseases
,
retinal diseases
Diabetes October 2010, Vol.60, 298-305. doi:https://doi.org/10.2337/db10-1198
Insulin Resistance, Defective Insulin-Mediated Fatty Acid Suppression, and Coronary Artery Calcification in Subjects With and Without Type 1 Diabetes: The CACTI Study
Irene E. Schauer; Janet K. Snell-Bergeon; Bryan C. Bergman; David M. Maahs; Adam Kretowski; Robert H. Eckel; Marian Rewers
Topics:
coronary arteriosclerosis
,
coronary artery calcium
,
diabetes mellitus, type 1
,
glucose
,
insulin
Diabetes October 2010, Vol.60, 306-314. doi:https://doi.org/10.2337/db10-0328
High Connectivity Between Reduced Cortical Thickness and Disrupted White Matter Tracts in Long-Standing Type 1 Diabetes
Daniel T. Franc; Christopher T. Kodl; Bryon A. Mueller; Ryan L. Muetzel; Kelvin O. Lim; Elizabeth R. Seaquist
Topics:
anisotropy
,
diabetes mellitus, type 1
,
gray matter
,
magnetic resonance imaging
,
white matter
Diabetes October 2010, Vol.60, 315-319. doi:https://doi.org/10.2337/db10-0598
Genetics
Targeted Inactivation of Kinesin-1 in Pancreatic β-Cells In Vivo Leads to Insulin Secretory Deficiency
Ju Cui; Zai Wang; Qianni Cheng; Raozhou Lin; Xin-Mei Zhang; Po Sing Leung; Neal G. Copeland; Nancy A. Jenkins; Kwok-Ming Yao; Jian-Dong Huang
Topics:
insulin
,
mice
,
pancreas
,
ripk2 gene
Diabetes September 2010, Vol.60, 320-330. doi:https://doi.org/10.2337/db09-1078
Association of a Fasting Glucose Genetic Risk Score With Subclinical Atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) Study
Laura J. Rasmussen-Torvik; Man Li; Wen H. Kao; David Couper; Eric Boerwinkle; Suzette J. Bielinski; Aaron R. Folsom; James S. Pankow
Topics:
aric trial
,
atherosclerosis
,
fasting blood glucose measurement
,
genetic risk
,
single nucleotide polymorphism
Diabetes October 2010, Vol.60, 331-335. doi:https://doi.org/10.2337/db10-0839
Both Polymorphic Variable Number of Tandem Repeats and Autoimmune Regulator Modulate Differential Expression of Insulin in Human Thymic Epithelial Cells
Topics:
aire gene
,
insulin
,
minisatellite repeats
,
thymic epithelial cells
,
luciferases
Diabetes September 2010, Vol.60, 336-344. doi:https://doi.org/10.2337/db10-0255
Genetic Predisposition to Long-Term Nondiabetic Deteriorations in Glucose Homeostasis: Ten-Year Follow-Up of the GLACIER Study
Frida Renström; Dmitry Shungin; Ingegerd Johansson; the MAGIC Investigators; Jose C. Florez; Göran Hallmans; Frank B. Hu; Paul W. Franks
Topics:
deuterium
,
fasting
,
fasting blood glucose measurement
,
follow-up
,
glucose
Diabetes September 2010, Vol.60, 345-354. doi:https://doi.org/10.2337/db10-0933
mt-Nd2a Modifies Resistance Against Autoimmune Type 1 Diabetes in NOD Mice at the Level of the Pancreatic β-Cell
Topics:
adoptive transfer
,
alleles
,
autoimmunity
,
clone cells
,
diabetes mellitus, type 1
Diabetes October 2010, Vol.60, 355-359. doi:https://doi.org/10.2337/db10-1241
Erratum
Erratum
Topics:
diabetes mellitus, experimental
Diabetes January 2011, Vol.60, 360. doi:https://doi.org/10.2337/db11-er01
Online Letters to the Editor
Comment on: Kim et al. (2010) Hypothalamic Angptl4/Fiaf Is a Novel Regulator of Food Intake and Body Weight. Diabetes;59:2772–2780
Topics:
angiopoietin-like 4 protein
,
eating
,
hypothalamus
Diabetes January 2011, Vol.60, e1. doi:https://doi.org/10.2337/db10-1348
Response to Comment on: Kim et al. (2010) Hypothalamic Angptl4/Fiaf Is a Novel Regulator of Food Intake and Body Weight. Diabetes;59:2772–2780
Topics:
angiopoietin-like 4 protein
,
eating
,
hypothalamus
Diabetes January 2011, Vol.60, e2. doi:https://doi.org/10.2337/db10-1457
Comment on: Kaiyala et al. (2010) Identification of Body Fat Mass as a Major Determinant of Metabolic Rate in Mice. Diabetes;59:1657–1666
Topics:
body fat
,
metabolic rate
,
mice
Diabetes January 2011, Vol.60, e3. doi:https://doi.org/10.2337/db10-1343
Response to Comment on: Kaiyala et al. (2010) Identification of Body Fat Mass as a Major Determinant of Metabolic Rate in Mice. Diabetes;59:1657–1666
Karl J. Kaiyala; Gregory J. Morton; Brian G. Leroux; Kayoko Ogimoto; Brent Wisse; Michael W. Schwartz
Topics:
body fat
,
metabolic rate
,
mice
Diabetes January 2011, Vol.60, e4. doi:https://doi.org/10.2337/db10-1445
Comment on: Matsushita et al. (2010) The Association of Hemoglobin A1c With Incident Heart Failure Among People Without Diabetes: The Atherosclerosis Risk in Communities Study. Diabetes;59:2020–2026
Topics:
aric trial
,
heart failure
,
hemoglobin a, glycosylated
Diabetes January 2011, Vol.60, e5. doi:https://doi.org/10.2337/db10-1381
Response to Comment on: Matsushita et al. (2010) The Association of Hemoglobin A1c With Incident Heart Failure Among People Without Diabetes: The Atherosclerosis Risk in Communities Study. Diabetes;59:2020–2026
Topics:
aric trial
,
heart failure
,
hemoglobin a, glycosylated
Diabetes January 2011, Vol.60, e6. doi:https://doi.org/10.2337/db10-1474
Comment on: Lin et al. (2010) Immune Cell–Derived C3 Is Required for Autoimmune Diabetes Induced by Multiple Low Doses of Streptozotocin. Diabetes;59: 2247–2252
Topics:
autoimmunity
,
streptozocin
,
complement system proteins
Diabetes January 2011, Vol.60, e7-e8. doi:https://doi.org/10.2337/db10-1298
