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1 October 2011
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ISSN 0012-1797
EISSN 1939-327X
Perspectives in Diabetes
Fatty Acids, Obesity, and Insulin Resistance: Time for a Reevaluation
Diabetes September 2011, Vol.60, 2441-2449. doi:https://doi.org/10.2337/db11-0425
The Complex Mechanism of Glutamate Dehydrogenase in Insulin Secretion
Diabetes September 2011, Vol.60, 2450-2454. doi:https://doi.org/10.2337/db10-1150
Commentary
Metabolism
Dysregulation of Placental Endothelial Lipase in Obese Women With Gestational Diabetes Mellitus
Martin Gauster; Ursula Hiden; Mireille van Poppel; Sasa Frank; Christian Wadsack; Sylvie Hauguel-de Mouzon; Gernot Desoye
Diabetes September 2011, Vol.60, 2457-2464. doi:https://doi.org/10.2337/db10-1434
Nrf2 Represses FGF21 During Long-Term High-Fat Diet–Induced Obesity in Mice
Dionysios V. Chartoumpekis; Panos G. Ziros; Agathoklis I. Psyrogiannis; Athanasios G. Papavassiliou; Venetsana E. Kyriazopoulou; Gerasimos P. Sykiotis; Ioannis G. Habeos
Diabetes September 2011, Vol.60, 2465-2473. doi:https://doi.org/10.2337/db11-0112
Obesity Studies
Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet–Induced Insulin Resistance
Yun Sok Lee; Pingping Li; Jin Young Huh; In Jae Hwang; Min Lu; Jong In Kim; Mira Ham; Saswata Talukdar; Ai Chen; Wendell J. Lu; Guatam K. Bandyopadhyay; Reto Schwendener; Jerrold Olefsky; Jae Bum Kim
Diabetes September 2011, Vol.60, 2474-2483. doi:https://doi.org/10.2337/db11-0194
Disruption of Hypoxia-Inducible Factor 1 in Adipocytes Improves Insulin Sensitivity and Decreases Adiposity in High-Fat Diet–Fed Mice
Changtao Jiang; Aijuan Qu; Tsutomu Matsubara; Tatyana Chanturiya; William Jou; Oksana Gavrilova; Yatrik M. Shah; Frank J. Gonzalez
Diabetes September 2011, Vol.60, 2484-2495. doi:https://doi.org/10.2337/db11-0174
Obesity-Associated Hepatosteatosis and Impairment of Glucose Homeostasis Are Attenuated by Haptoglobin Deficiency
Simonetta Lisi; Olimpia Gamucci; Teresa Vottari; Gaia Scabia; Marcella Funicello; Matilde Marchi; Giulia Galli; Ivan Arisi; Rossella Brandi; Mara D’Onofrio; Aldo Pinchera; Ferruccio Santini; Margherita Maffei
Diabetes September 2011, Vol.60, 2496-2505. doi:https://doi.org/10.2337/db10-1536
Islet Studies
Inhibition of Id1 Augments Insulin Secretion and Protects Against High-Fat Diet–Induced Glucose Intolerance
Diabetes September 2011, Vol.60, 2506-2514. doi:https://doi.org/10.2337/db11-0083
Acute Sulfonylurea Therapy at Disease Onset Can Cause Permanent Remission of KATP-Induced Diabetes
Diabetes September 2011, Vol.60, 2515-2522. doi:https://doi.org/10.2337/db11-0538
Advanced Glycation End Products Are Direct Modulators of β-Cell Function
Melinda T. Coughlan; Felicia Y.T. Yap; David C.K. Tong; Sofianos Andrikopoulos; Anna Gasser; Vicki Thallas-Bonke; Diane E. Webster; Jun-ichi Miyazaki; Thomas W. Kay; Robyn M. Slattery; David M. Kaye; Brian G. Drew; Bronwyn A. Kingwell; Spiros Fourlanos; Per-Henrik Groop; Leonard C. Harrison; Mikael Knip; Josephine M. Forbes
Diabetes September 2011, Vol.60, 2523-2532. doi:https://doi.org/10.2337/db10-1033
Mechanisms of Control of the Free Ca2+ Concentration in the Endoplasmic Reticulum of Mouse Pancreatic β-Cells: Interplay With Cell Metabolism and [Ca2+]c and Role of SERCA2b and SERCA3
Magalie A. Ravier; Dorothée Daro; Leticia Prates Roma; Jean-Christophe Jonas; Rui Cheng-Xue; Frans C. Schuit; Patrick Gilon
Diabetes September 2011, Vol.60, 2533-2545. doi:https://doi.org/10.2337/db10-1543
Activation of Protein Kinase C-ζ in Pancreatic β-Cells In Vivo Improves Glucose Tolerance and Induces β-Cell Expansion via mTOR Activation
Silvia Velazquez-Garcia; Shelley Valle; Taylor C. Rosa; Karen K. Takane; Cem Demirci; Juan C. Alvarez-Perez; Jose M. Mellado-Gil; Sara Ernst; Donald K. Scott; Rupangi C. Vasavada; Laura C. Alonso; Adolfo Garcia-Ocaña
Diabetes September 2011, Vol.60, 2546-2559. doi:https://doi.org/10.2337/db10-1783
Immunology and Transplantation
Rituximab Selectively Suppresses Specific Islet Antibodies
Liping Yu; Kevan Herold; Heidi Krause-Steinrauf; Paula L. McGee; Brian Bundy; Alberto Pugliese; Jeff Krischer; George S. Eisenbarth; for the Type 1 Diabetes TrialNet Anti-CD20 Study Group
Diabetes September 2011, Vol.60, 2560-2565. doi:https://doi.org/10.2337/db11-0674
Reduced Serum Vitamin D–Binding Protein Levels Are Associated With Type 1 Diabetes
Dustin Blanton; Zhao Han; Lindsey Bierschenk; M.V. Prasad Linga-Reddy; Hongjie Wang; Michael Clare-Salzler; Michael Haller; Desmond Schatz; Courtney Myhr; Jin-Xiong She; Clive Wasserfall; Mark Atkinson
Diabetes September 2011, Vol.60, 2566-2570. doi:https://doi.org/10.2337/db11-0576
Donor Islet Endothelial Cells in Pancreatic Islet Revascularization
Daniel Nyqvist; Stephan Speier; Rayner Rodriguez-Diaz; R. Damaris Molano; Saša Lipovsek; Marjan Rupnik; Andrea Dicker; Erwin Ilegems; Elsie Zahr-Akrawi; Judith Molina; Maite Lopez-Cabeza; Susana Villate; Midhat H. Abdulreda; Camillo Ricordi; Alejandro Caicedo; Antonello Pileggi; Per-Olof Berggren
Diabetes September 2011, Vol.60, 2571-2577. doi:https://doi.org/10.2337/db10-1711
Pathophysiology
Impaired Glucose Tolerance in the Absence of Adenosine A1 Receptor Signaling
Robert Faulhaber-Walter; William Jou; Diane Mizel; Lingli Li; Jiandi Zhang; Soo Mi Kim; Yuning Huang; Min Chen; Josephine P. Briggs; Oksana Gavrilova; Jurgen B. Schnermann
Diabetes September 2011, Vol.60, 2578-2587. doi:https://doi.org/10.2337/db11-0058
Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance: Another Paradox in Endurance-Trained Athletes?
Francesca Amati; John J. Dubé; Elvis Alvarez-Carnero; Martin M. Edreira; Peter Chomentowski; Paul M. Coen; Galen E. Switzer; Perry E. Bickel; Maja Stefanovic-Racic; Frederico G.S. Toledo; Bret H. Goodpaster
Diabetes September 2011, Vol.60, 2588-2597. doi:https://doi.org/10.2337/db10-1221
GLUT2 Accumulation in Enterocyte Apical and Intracellular Membranes: A Study in Morbidly Obese Human Subjects and ob/ob and High Fat–Fed Mice
Amal Ait-Omar; Milena Monteiro-Sepulveda; Christine Poitou; Maude Le Gall; Aurélie Cotillard; Jules Gilet; Kevin Garbin; Anne Houllier; Danièle Château; Amélie Lacombe; Nicolas Veyrie; Danielle Hugol; Joan Tordjman; Christophe Magnan; Patricia Serradas; Karine Clément; Armelle Leturque; Edith Brot-Laroche
Diabetes September 2011, Vol.60, 2598-2607. doi:https://doi.org/10.2337/db10-1740
Pharmacology and Therapeutics
Vascular Dysfunction in Experimental Diabetes Is Improved by Pentaerithrityl Tetranitrate but Not Isosorbide-5-Mononitrate Therapy
Swenja Schuhmacher; Matthias Oelze; Franziska Bollmann; Hartmut Kleinert; Christian Otto; Tjebo Heeren; Sebastian Steven; Michael Hausding; Maike Knorr; Andrea Pautz; Kurt Reifenberg; Eberhard Schulz; Tommaso Gori; Philip Wenzel; Thomas Münzel; Andreas Daiber
Diabetes September 2011, Vol.60, 2608-2616. doi:https://doi.org/10.2337/db10-1395
Anti-inflammatory and Antioxidant Properties of HDLs Are Impaired in Type 2 Diabetes
Cecilia Morgantini; Andrea Natali; Beatrice Boldrini; Satoshi Imaizumi; Mohamad Navab; Alan M. Fogelman; Ele Ferrannini; Srinivasa T. Reddy
Diabetes September 2011, Vol.60, 2617-2623. doi:https://doi.org/10.2337/db11-0378
Genetics
Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes
Rona J. Strawbridge; Josée Dupuis; Inga Prokopenko; Adam Barker; Emma Ahlqvist; Denis Rybin; John R. Petrie; Mary E. Travers; Nabila Bouatia-Naji; Antigone S. Dimas; Alexandra Nica; Eleanor Wheeler; Han Chen; Benjamin F. Voight; Jalal Taneera; Stavroula Kanoni; John F. Peden; Fabiola Turrini; Stefan Gustafsson; Carina Zabena; Peter Almgren; David J.P. Barker; Daniel Barnes; Elaine M. Dennison; Johan G. Eriksson; Per Eriksson; Elodie Eury; Lasse Folkersen; Caroline S. Fox; Timothy M. Frayling; Anuj Goel; Harvest F. Gu; Momoko Horikoshi; Bo Isomaa; Anne U. Jackson; Karen A. Jameson; Eero Kajantie; Julie Kerr-Conte; Teemu Kuulasmaa; Johanna Kuusisto; Ruth J.F. Loos; Jian'an Luan; Konstantinos Makrilakis; Alisa K. Manning; María Teresa Martínez-Larrad; Narisu Narisu; Maria Nastase Mannila; John Öhrvik; Clive Osmond; Laura Pascoe; Felicity Payne; Avan A. Sayer; Bengt Sennblad; Angela Silveira; Alena Stančáková; Kathy Stirrups; Amy J. Swift; Ann-Christine Syvänen; Tiinamaija Tuomi; Ferdinand M. van 't Hooft; Mark Walker; Michael N. Weedon; Weijia Xie; Björn Zethelius; the DIAGRAM Consortium; the GIANT Consortium; the MuTHER Consortium; the CARDIoGRAM Consortium; the C4D Consortium; Halit Ongen; Anders Mälarstig; Jemma C. Hopewell; Danish Saleheen; John Chambers; Sarah Parish; John Danesh; Jaspal Kooner; Claes-Göran Östenson; Lars Lind; Cyrus C. Cooper; Manuel Serrano-Ríos; Ele Ferrannini; Tom J. Forsen; Robert Clarke; Maria Grazia Franzosi; Udo Seedorf; Hugh Watkins; Philippe Froguel; Paul Johnson; Panos Deloukas; Francis S. Collins; Markku Laakso; Emmanouil T. Dermitzakis; Michael Boehnke; Mark I. McCarthy; Nicholas J. Wareham; Leif Groop; François Pattou; Anna L. Gloyn; George V. Dedoussis; Valeriya Lyssenko; James B. Meigs; Inês Barroso; Richard M. Watanabe; Erik Ingelsson; Claudia Langenberg; Anders Hamsten; Jose C. Florez
Diabetes September 2011, Vol.60, 2624-2634. doi:https://doi.org/10.2337/db11-0415
Evidence That HLA Class I and II Associations With Type 1 Diabetes, Autoantibodies to GAD and Autoantibodies to IA-2, Are Distinct
Joanna M.M. Howson; Helen Stevens; Deborah J. Smyth; Neil M. Walker; Kyla A. Chandler; Polly J. Bingley; John A. Todd
Diabetes September 2011, Vol.60, 2635-2644. doi:https://doi.org/10.2337/db11-0131
Genetic Analysis of Adult-Onset Autoimmune Diabetes
Joanna M.M. Howson; Silke Rosinger; Deborah J. Smyth; Bernhard O. Boehm; the ADBW-END Study Group; John A. Todd
Diabetes September 2011, Vol.60, 2645-2653. doi:https://doi.org/10.2337/db11-0364
Effects of Genetic Susceptibility for Type 2 Diabetes on the Evolution of Glucose Homeostasis Traits Before and After Diabetes Diagnosis: Data From the D.E.S.I.R. Study
Alain Gautier; Ronan Roussel; Céline Lange; Xavier Piguel; Stéphane Cauchi; Sylviane Vol; Philippe Froguel; Beverley Balkau; Fabrice Bonnet
Diabetes September 2011, Vol.60, 2654-2663. doi:https://doi.org/10.2337/db10-1442
