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Editorial

Poverty and Obesity in the U.S.

James A. Levine

Abstract

View articletitled, Poverty and Obesity in the U.S.

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Topics: obesity

Diabetes October 2011, Vol.60, 2667-2668. doi:https://doi.org/10.2337/db11-1118

It's Time to Mow the GRAS in Type 1 Diabetes

Desmond A. Schatz; S. Robert Levine; Mark A. Atkinson

Extract

View articletitled, It's Time to Mow the GRAS in Type 1 Diabetes

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Topics: diabetes mellitus, type 1

Diabetes October 2011, Vol.60, 2669-2671. doi:https://doi.org/10.2337/db11-1158

Perspectives in Diabetes

Artificial Pancreas: Past, Present, Future

Claudio Cobelli; Eric Renard; Boris Kovatchev

Extract

View articletitled, Artificial Pancreas: Past, Present, Future

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Topics: artificial pancreas , glucose , insulin , sensor , continuous glucose monitoring

Diabetes October 2011, Vol.60, 2672-2682. doi:https://doi.org/10.2337/db11-0654

Commentary

Nrf2 Activators as Attractive Therapeutics for Diabetic Nephropathy

Judy B. de Haan

Abstracts

View articletitled, Nrf2 Activators as Attractive Therapeutics for Diabetic Nephropathy

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Topics: diabetic nephropathy , transcriptional activation , kelch-like ech-associated protein 1

Diabetes October 2011, Vol.60, 2683-2684. doi:https://doi.org/10.2337/db11-1072

FUT2 Nonfunctional Variant: A “Missing Link” Between Genes and Environment in Type 1 Diabetes?

Ping Yang; Hong-Liang Li; Cong-Yi Wang

Abstracts

View articletitled, FUT2 Nonfunctional Variant: A “Missing Link” Between Genes and Environment in Type 1 Diabetes?

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Topics: diabetes mellitus, type 1 , genes

Diabetes October 2011, Vol.60, 2685-2687. doi:https://doi.org/10.2337/db11-1104

Metabolomics Makes a Mark: Early Changes Associated With Autoimmune Diabetes

R. David Leslie; Huriya Beyan

Abstracts

View articletitled, Metabolomics Makes a Mark: Early Changes Associated With Autoimmune Diabetes

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Topics: autoantibodies , autoimmunity , metabolomics , diabetes mellitus, type 1 , child

Diabetes October 2011, Vol.60, 2688-2690. doi:https://doi.org/10.2337/db11-1177

Metabolism

Mediobasal Hypothalamic SIRT1 Is Essential for Resveratrol’s Effects on Insulin Action in Rats

Colette M. Knight; Roger Gutierrez-Juarez; Tony K.T. Lam; Isabel Arrieta-Cruz; Loli Huang; Gary Schwartz; Nir Barzilai; Luciano Rossetti

Abstracts

View articletitled, Mediobasal Hypothalamic SIRT1 Is Essential for Resveratrol’s Effects on Insulin Action in Rats

Supplementary data

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Topics: glucose , hypothalamus , insulin , resveratrol , rats

Diabetes October 2011, Vol.60, 2691-2700. doi:https://doi.org/10.2337/db10-0987

CCK Stimulation of GLP-1 Neurons Involves α₁-Adrenoceptor–Mediated Increase in Glutamatergic Synaptic Inputs

Kazunari Hisadome; Frank Reimann; Fiona M. Gribble; Stefan Trapp

Abstract

View articletitled, CCK Stimulation of GLP-1 Neurons Involves α1-Adrenoceptor–Mediated Increase in Glutamatergic Synaptic Inputs

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Topics: epinephrine , neurons , adrenergic receptor , glucagon-like peptide 1 , agonists

Diabetes October 2011, Vol.60, 2701-2709. doi:https://doi.org/10.2337/db11-0489

β-Cell Uncoupling Protein 2 Regulates Reactive Oxygen Species Production, Which Influences Both Insulin and Glucagon Secretion

Christine A. Robson-Doucette; Sobia Sultan; Emma M. Allister; Jakob D. Wikstrom; Vasilij Koshkin; Alpana Bhattacharjee; Kacey J. Prentice; Samuel B. Sereda; Orian S. Shirihai; Michael B. Wheeler

Abstracts

View articletitled, β-Cell Uncoupling Protein 2 Regulates Reactive Oxygen Species Production, Which Influences Both Insulin and Glucagon Secretion

Supplementary data

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Topics: glucagon , glucose , insulin , mice , glucagon secretion

Diabetes October 2011, Vol.60, 2710-2719. doi:https://doi.org/10.2337/db11-0132

Hepatic Glucagon Action Is Essential for Exercise-Induced Reversal of Mouse Fatty Liver

Eric D. Berglund; Daniel G. Lustig; Richard A. Baheza; Clinton M. Hasenour; Robert S. Lee-Young; E. Patrick Donahue; Sara E. Lynes; Larry L. Swift; Maureen J. Charron; Bruce M. Damon; David H. Wasserman

Abstract

View articletitled, Hepatic Glucagon Action Is Essential for Exercise-Induced Reversal of Mouse Fatty Liver

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Topics: fatty liver , glucagon , glucagon receptors , liver , mice

Diabetes October 2011, Vol.60, 2720-2729. doi:https://doi.org/10.2337/db11-0455

Nonthyrotoxic Prevention of Diet-Induced Insulin Resistance by 3,5-Diiodo-L-Thyronine in Rats

Pieter de Lange; Federica Cioffi; Rosalba Senese; Maria Moreno; Assunta Lombardi; Elena Silvestri; Rita De Matteis; Lillà Lionetti; Maria Pina Mollica; Fernando Goglia; Antonia Lanni

Abstract

View articletitled, Nonthyrotoxic Prevention of Diet-Induced Insulin Resistance by 3,5-Diiodo-L-Thyronine in Rats

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Topics: transverse spin relaxation time , rats , fatty acid oxidation , mitochondria , insulin resistance

Diabetes October 2011, Vol.60, 2730-2739. doi:https://doi.org/10.2337/db11-0207

Age- and Islet Autoimmunity–Associated Differences in Amino Acid and Lipid Metabolites in Children at Risk for Type 1 Diabetes

Maren Pflueger; Tuulikki Seppänen-Laakso; Tapani Suortti; Tuulia Hyötyläinen; Peter Achenbach; Ezio Bonifacio; Matej Orešič; Anette-G. Ziegler

Abstracts

View articletitled, Age- and Islet Autoimmunity–Associated Differences in Amino Acid and Lipid Metabolites in Children at Risk for Type 1 Diabetes

Supplementary data

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Topics: amino acids , autoantibodies , autoimmunity , child , diabetes mellitus, type 1

Diabetes October 2011, Vol.60, 2740-2747. doi:https://doi.org/10.2337/db10-1652

Vitamin D, Insulin Secretion, Sensitivity, and Lipids: Results From a Case-Control Study and a Randomized Controlled Trial Using Hyperglycemic Clamp Technique

Guri Grimnes; Yngve Figenschau; Bjørg Almås; Rolf Jorde

Abstracts

View articletitled, Vitamin D, Insulin Secretion, Sensitivity, and Lipids: Results From a Case-Control Study and a Randomized Controlled Trial Using Hyperglycemic Clamp Technique

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Topics: hemoglobin a, glycosylated , hyperglycemic agents , lipids , vitamin d , insulin secretion

Diabetes October 2011, Vol.60, 2748-2757. doi:https://doi.org/10.2337/db11-0650

Fibroblast Growth Factor 21 (FGF21) in Human Cerebrospinal Fluid: Relationship With Plasma FGF21 and Body Adiposity

Bee K. Tan; Manfred Hallschmid; Raghu Adya; Werner Kern; Hendrik Lehnert; Harpal S. Randeva

Abstract

View articletitled, Fibroblast Growth Factor 21 (FGF21) in Human Cerebrospinal Fluid: Relationship With Plasma FGF21 and Body Adiposity

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Topics: body mass index procedure , cerebrospinal fluid , fibroblast growth factors , obesity , plasma

Diabetes October 2011, Vol.60, 2758-2762. doi:https://doi.org/10.2337/db11-0672

FoxO6 Integrates Insulin Signaling With Gluconeogenesis in the Liver

Dae Hyun Kim; German Perdomo; Ting Zhang; Sandra Slusher; Sojin Lee; Brett E. Phillips; Yong Fan; Nick Giannoukakis; Roberto Gramignoli; Stephen Strom; Steven Ringquist; H. Henry Dong

Abstract

View articletitled, FoxO6 Integrates Insulin Signaling With Gluconeogenesis in the Liver

Supplementary data

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Topics: insulin , liver , mice , gluconeogenesis , fasting

Diabetes October 2011, Vol.60, 2763-2774. doi:https://doi.org/10.2337/db11-0548

Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic Obese and Diet-Induced Leptin-Resistant Mice

Amandine Everard; Vladimir Lazarevic; Muriel Derrien; Myriam Girard; Giulio G. Muccioli; Audrey M. Neyrinck; Sam Possemiers; Ann Van Holle; Patrice François; Willem M. de Vos; Nathalie M. Delzenne; Jacques Schrenzel; Patrice D. Cani

Abstracts

View articletitled, Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic Obese and Diet-Induced Leptin-Resistant Mice

Supplementary data

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Topics: diet , leptin , mice , mice, obese , microbiome

Diabetes October 2011, Vol.60, 2775-2786. doi:https://doi.org/10.2337/db11-0227

Similar VLDL-TG Storage in Visceral and Subcutaneous Fat in Obese and Lean Women

Esben Søndergaard; Birgitte Nellemann; Lars P. Sørensen; Lars C. Gormsen; Jens S. Christiansen; Erik Ernst; Margit Dueholm; Søren Nielsen

Abstracts

View articletitled, Similar VLDL-TG Storage in Visceral and Subcutaneous Fat in Obese and Lean Women

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Topics: lipoproteins, vldl , adipose tissue , obesity

Diabetes October 2011, Vol.60, 2787-2791. doi:https://doi.org/10.2337/db11-0604

Signal Transduction

Endothelial NO/cGMP/VASP Signaling Attenuates Kupffer Cell Activation and Hepatic Insulin Resistance Induced by High-Fat Feeding

Sanshiro Tateya; Norma O. Rizzo; Priya Handa; Andrew M. Cheng; Vicki Morgan-Stevenson; Guenter Daum; Alexander W. Clowes; Gregory J. Morton; Michael W. Schwartz; Francis Kim

Abstract

View articletitled, Endothelial NO/cGMP/VASP Signaling Attenuates Kupffer Cell Activation and Hepatic Insulin Resistance Induced by High-Fat Feeding

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Topics: cyclic gmp , inflammation , insulin , insulin resistance , kupffer cells

Diabetes October 2011, Vol.60, 2792-2801. doi:https://doi.org/10.2337/db11-0255

Obesity Studies

Subcutaneous Adipose Tissue Macrophage Infiltration Is Associated With Hepatic and Visceral Fat Deposition, Hyperinsulinemia, and Stimulation of NF-κB Stress Pathway

Kim-Anne Lê; Swapna Mahurkar; Tanya L. Alderete; Rebecca E. Hasson; Tanja C. Adam; Joon Sung Kim; Elizabeth Beale; Chen Xie; Andrew S. Greenberg; Hooman Allayee; Michael I. Goran

Abstracts

View articletitled, Subcutaneous Adipose Tissue Macrophage Infiltration Is Associated With Hepatic and Visceral Fat Deposition, Hyperinsulinemia, and Stimulation of NF-κB Stress Pathway

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Topics: adipose tissue , inflammation , insulin , macrophages , obesity

Diabetes October 2011, Vol.60, 2802-2809. doi:https://doi.org/10.2337/db10-1263

Elevated NF-κB Activation Is Conserved in Human Myocytes Cultured From Obese Type 2 Diabetic Patients and Attenuated by AMP-Activated Protein Kinase

Charlotte J. Green; Maria Pedersen; Bente K. Pedersen; Camilla Scheele

Abstract

View articletitled, Elevated NF-κB Activation Is Conserved in Human Myocytes Cultured From Obese Type 2 Diabetic Patients and Attenuated by AMP-Activated Protein Kinase

Supplementary data

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Topics: ampk , diabetes mellitus, type 2 , inflammation , muscle cells , obesity

Diabetes October 2011, Vol.60, 2810-2819. doi:https://doi.org/10.2337/db11-0263

Aberrant Accumulation of Undifferentiated Myeloid Cells in the Adipose Tissue of CCR2-Deficient Mice Delays Improvements in Insulin Sensitivity

Dario A. Gutierrez; Arion Kennedy; Jeb S. Orr; Emily K. Anderson; Corey D. Webb; William K. Gerrald; Alyssa H. Hasty

Abstract

View articletitled, Aberrant Accumulation of Undifferentiated Myeloid Cells in the Adipose Tissue of CCR2-Deficient Mice Delays Improvements in Insulin Sensitivity

Supplementary data

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Topics: adipose tissue , macrophage-1 antigen , mice , flow cytometry , obesity

Diabetes October 2011, Vol.60, 2820-2829. doi:https://doi.org/10.2337/db11-0314

Islet Studies

Role of Lipid Peroxidation and PPAR-δ in Amplifying Glucose-Stimulated Insulin Secretion

Guy Cohen; Yael Riahi; Ofer Shamni; Michel Guichardant; Chryssostomos Chatgilialoglu; Carla Ferreri; Nurit Kaiser; Shlomo Sasson

Abstract

View articletitled, Role of Lipid Peroxidation and PPAR-δ in Amplifying Glucose-Stimulated Insulin Secretion

Supplementary data

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Topics: glucose , insulin secretion , peroxisome proliferator-activated receptors

Diabetes October 2011, Vol.60, 2830-2842. doi:https://doi.org/10.2337/db11-0347

Increased Phagocyte-Like NADPH Oxidase and ROS Generation in Type 2 Diabetic ZDF Rat and Human Islets: Role of Rac1–JNK1/2 Signaling Pathway in Mitochondrial Dysregulation in the Diabetic Islet

Ismail Syed; Chandrashekara N. Kyathanahalli; Bhavaani Jayaram; Sudha Govind; Christopher J. Rhodes; Renu A. Kowluru; Anjaneyulu Kowluru

Abstract

View articletitled, Increased Phagocyte-Like NADPH Oxidase and ROS Generation in Type 2 Diabetic ZDF Rat and Human Islets: Role of Rac1–JNK1/2 Signaling Pathway in Mitochondrial Dysregulation in the Diabetic Islet

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Topics: caspase-3 , glucose , mitochondria , nadph oxidases , palmitates

Diabetes October 2011, Vol.60, 2843-2852. doi:https://doi.org/10.2337/db11-0809

High-Resolution Magnetic Resonance Imaging Quantitatively Detects Individual Pancreatic Islets

Smaragda Lamprianou; Riikka Immonen; Christine Nabuurs; Asllan Gjinovci; Laurent Vinet; Xavier C.R. Montet; Rolf Gruetter; Paolo Meda

Abstract

View articletitled, High-Resolution Magnetic Resonance Imaging Quantitatively Detects Individual Pancreatic Islets

Supplementary data

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Topics: magnetic resonance imaging , mice , pancreas

Diabetes October 2011, Vol.60, 2853-2860. doi:https://doi.org/10.2337/db11-0726

Specific Control of Pancreatic Endocrine β- and δ-Cell Mass by Class IIa Histone Deacetylases HDAC4, HDAC5, and HDAC9

Olivia Lenoir; Kathleen Flosseau; Feng Xia Ma; Bertrand Blondeau; Antonello Mai; Rhonda Bassel-Duby; Philippe Ravassard; Eric N. Olson; Cécile Haumaitre; Raphaël Scharfmann

Abstracts

View articletitled, Specific Control of Pancreatic Endocrine β- and δ-Cell Mass by Class IIa Histone Deacetylases HDAC4, HDAC5, and HDAC9

Supplementary data

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Topics: hdac9 gene , histone deacetylase , insulin , pancreas , somatostatin

Diabetes October 2011, Vol.60, 2861-2871. doi:https://doi.org/10.2337/db11-0440

Normal Glucagon Signaling and β-Cell Function After Near-Total α-Cell Ablation in Adult Mice

Fabrizio Thorel; Nicolas Damond; Simona Chera; Andreas Wiederkehr; Bernard Thorens; Paolo Meda; Claes B. Wollheim; Pedro L. Herrera

Abstract

View articletitled, Normal Glucagon Signaling and β-Cell Function After Near-Total α-Cell Ablation in Adult Mice

Supplementary data

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Topics: ablation , glucagon , mice , pancreas , insulin

Diabetes October 2011, Vol.60, 2872-2882. doi:https://doi.org/10.2337/db11-0876

FoxO Feedback Control of Basal IRS-2 Expression in Pancreatic β-Cells Is Distinct From That in Hepatocytes

Shin Tsunekawa; Damien Demozay; Isabelle Briaud; Jill McCuaig; Domenico Accili; Roland Stein; Christopher J. Rhodes

Abstracts

View articletitled, FoxO Feedback Control of Basal IRS-2 Expression in Pancreatic β-Cells Is Distinct From That in Hepatocytes

Supplementary data

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Topics: 1-phosphatidylinositol 3-kinase , forkhead box protein o1 , glucose , insulin , insulin-like growth factor i

Diabetes October 2011, Vol.60, 2883-2891. doi:https://doi.org/10.2337/db11-0340

Specific Glucose-Induced Control of Insulin Receptor Substrate-2 Expression Is Mediated via Ca²⁺-Dependent Calcineurin/NFAT Signaling in Primary Pancreatic Islet β-Cells

Damien Demozay; Shin Tsunekawa; Isabelle Briaud; Ramila Shah; Christopher J. Rhodes

Abstracts

View articletitled, Specific Glucose-Induced Control of Insulin Receptor Substrate-2 Expression Is Mediated via Ca2+-Dependent Calcineurin/NFAT Signaling in Primary Pancreatic Islet β-Cells

Supplementary data

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Topics: calcineurin , glucose , endocrine pancreas

Diabetes October 2011, Vol.60, 2892-2902. doi:https://doi.org/10.2337/db11-0341

Immunology and Transplantation

Expansion of Th17 Cells and Functional Defects in T Regulatory Cells Are Key Features of the Pancreatic Lymph Nodes in Patients With Type 1 Diabetes

Alessandra Ferraro; Carlo Socci; Angela Stabilini; Andrea Valle; Paolo Monti; Lorenzo Piemonti; Rita Nano; Sven Olek; Paola Maffi; Marina Scavini; Antonio Secchi; Carlo Staudacher; Ezio Bonifacio; Manuela Battaglia

Abstracts

View articletitled, Expansion of Th17 Cells and Functional Defects in T Regulatory Cells Are Key Features of the Pancreatic Lymph Nodes in Patients With Type 1 Diabetes

Supplementary data

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Topics: antigens, cd25 , diabetes mellitus, type 1 , donors , foxp3 gene , regulatory t-lymphocytes

Diabetes October 2011, Vol.60, 2903-2913. doi:https://doi.org/10.2337/db11-0090

Loss of Intra-Islet CD20 Expression May Complicate Efficacy of B-Cell–Directed Type 1 Diabetes Therapies

David V. Serreze; Harold D. Chapman; Marijke Niens; Robert Dunn; Marilyn R. Kehry; John P. Driver; Michael Haller; Clive Wasserfall; Mark A. Atkinson

Abstract

View articletitled, Loss of Intra-Islet CD20 Expression May Complicate Efficacy of B-Cell–Directed Type 1 Diabetes Therapies

Supplementary data

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Topics: b-lymphocytes , cd20 antigens , mice, inbred nod , antibodies

Diabetes October 2011, Vol.60, 2914-2921. doi:https://doi.org/10.2337/db11-0705

Deletion of the G6pc2 Gene Encoding the Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Does Not Affect the Progression or Incidence of Type 1 Diabetes in NOD/ShiLtJ Mice

James K. Oeser; Vrajesh V. Parekh; Yingda Wang; Naresh K. Jegadeesh; Suparna A. Sarkar; Randall Wong; Catherine E. Lee; Lynley D. Pound; John C. Hutton; Luc Van Kaer; Richard M. O’Brien

Abstract

View articletitled, Deletion of the G6pc2 Gene Encoding the Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Does Not Affect the Progression or Incidence of Type 1 Diabetes in NOD/ShiLtJ Mice

Supplementary data

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Topics: diabetes mellitus, type 1 , mice , peptides , t-lymphocytes , antigens

Diabetes October 2011, Vol.60, 2922-2927. doi:https://doi.org/10.2337/db11-0220

Pathophysiology

Targeting Curcusomes to Inflammatory Dendritic Cells Inhibits NF-κB and Improves Insulin Resistance in Obese Mice

Suman Kumar Yekollu; Ranjeny Thomas; Brendan O’Sullivan

Abstract

View articletitled, Targeting Curcusomes to Inflammatory Dendritic Cells Inhibits NF-κB and Improves Insulin Resistance in Obese Mice

Supplementary data

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Topics: cytokine , insulin resistance , liposomes , liver , macrophages

Diabetes October 2011, Vol.60, 2928-2938. doi:https://doi.org/10.2337/db11-0275

Angiotensin II Receptors Modulate Muscle Microvascular and Metabolic Responses to Insulin In Vivo

Weidong Chai; Wenhui Wang; Zhenhua Dong; Wenhong Cao; Zhenqi Liu

Abstracts

View articletitled, Angiotensin II Receptors Modulate Muscle Microvascular and Metabolic Responses to Insulin In Vivo

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Topics: angiotensin ii , insulin , losartan , glucose , plasma

Diabetes October 2011, Vol.60, 2939-2946. doi:https://doi.org/10.2337/db10-1691

Prospective Associations of Vitamin D With β-Cell Function and Glycemia: The PROspective Metabolism and ISlet cell Evaluation (PROMISE) Cohort Study

Sheena Kayaniyil; Ravi Retnakaran; Stewart B. Harris; Reinhold Vieth; Julia A. Knight; Hertzel C. Gerstein; Bruce A. Perkins; Bernard Zinman; Anthony J. Hanley

Abstract

View articletitled, Prospective Associations of Vitamin D With β-Cell Function and Glycemia: The PROspective Metabolism and ISlet cell Evaluation (PROMISE) Cohort Study

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Topics: diabetes mellitus, type 2 , follow-up , glucose , oral glucose tolerance test , vitamin d

Diabetes October 2011, Vol.60, 2947-2953. doi:https://doi.org/10.2337/db11-0465

Potential Role of Regulatory T Cells in Reversing Obesity-Linked Insulin Resistance and Diabetic Nephropathy

Kathrin Eller; Alexander Kirsch; Anna M. Wolf; Sieghart Sopper; Andrea Tagwerker; Ursula Stanzl; Dominik Wolf; Wolfgang Patsch; Alexander R. Rosenkranz; Philipp Eller

Abstract

View articletitled, Potential Role of Regulatory T Cells in Reversing Obesity-Linked Insulin Resistance and Diabetic Nephropathy

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Topics: diabetic nephropathy , insulin resistance , mice , obesity , regulatory t-lymphocytes

Diabetes October 2011, Vol.60, 2954-2962. doi:https://doi.org/10.2337/db11-0358

TRB3 Gene Silencing Alleviates Diabetic Cardiomyopathy in a Type 2 Diabetic Rat Model

Yun Ti; Guo-lu Xie; Zhi-hao Wang; Xiao-lei Bi; Wen-yuan Ding; Jia Wang; Gui-hua Jiang; Pei-li Bu; Yun Zhang; Ming Zhong; Wei Zhang

Abstracts

View articletitled, TRB3 Gene Silencing Alleviates Diabetic Cardiomyopathy in a Type 2 Diabetic Rat Model

Supplementary data

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Topics: collagen , echocardiography , gene silencing , heart failure , insulin resistance

Diabetes October 2011, Vol.60, 2963-2974. doi:https://doi.org/10.2337/db11-0549

Complications

miR-146a–Mediated Extracellular Matrix Protein Production in Chronic Diabetes Complications

Biao Feng; Shali Chen; Kara McArthur; Yuexiu Wu; Subhrojit Sen; Qingming Ding; Ross D. Feldman; Subrata Chakrabarti

Abstract

View articletitled, miR-146a–Mediated Extracellular Matrix Protein Production in Chronic Diabetes Complications

Supplementary data

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Topics: diabetes mellitus complications , down-regulation , endothelial cells , glucose , micrornas

Diabetes October 2011, Vol.60, 2975-2984. doi:https://doi.org/10.2337/db11-0478

Targeted Inhibition of Calpain Reduces Myocardial Hypertrophy and Fibrosis in Mouse Models of Type 1 Diabetes

Ying Li; Jian Ma; Huaqing Zhu; Manpreet Singh; David Hill; Peter A. Greer; J. Malcolm Arnold; E. Dale Abel; Tianqing Peng

Abstract

View articletitled, Targeted Inhibition of Calpain Reduces Myocardial Hypertrophy and Fibrosis in Mouse Models of Type 1 Diabetes

Supplementary data

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Topics: calpain , diabetes mellitus, type 1 , heart , mice , streptozocin

Diabetes October 2011, Vol.60, 2985-2994. doi:https://doi.org/10.2337/db10-1333

Intervention With an Erythropoietin-Derived Peptide Protects Against Neuroglial and Vascular Degeneration During Diabetic Retinopathy

Carmel M. McVicar; Ross Hamilton; Liza M. Colhoun; Tom A. Gardiner; Michael Brines; Anthony Cerami; Alan W. Stitt

Abstracts

View articletitled, Intervention With an Erythropoietin-Derived Peptide Protects Against Neuroglial and Vascular Degeneration During Diabetic Retinopathy

Supplementary data

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Topics: diabetic retinopathy , neovascularization, pathologic , peptides , rats , retina

Diabetes October 2011, Vol.60, 2995-3005. doi:https://doi.org/10.2337/db11-0026

Prospectively Determined Impact of Type 1 Diabetes on Brain Volume During Development

Dana C. Perantie; Jonathan M. Koller; Patrick M. Weaver; Heather M. Lugar; Kevin J. Black; Neil H. White; Tamara Hershey

Abstracts

View articletitled, Prospectively Determined Impact of Type 1 Diabetes on Brain Volume During Development

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Topics: brain , brain volume , follow-up , hemoglobin a, glycosylated , hyperglycemia

Diabetes October 2011, Vol.60, 3006-3014. doi:https://doi.org/10.2337/db11-0589

Arginase-2 Mediates Diabetic Renal Injury

Sidney M. Morris, Jr.; Ting Gao; Timothy K. Cooper; Diane Kepka-Lenhart; Alaa S. Awad

Abstract

View articletitled, Arginase-2 Mediates Diabetic Renal Injury

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Topics: arginase , kidney , mice , streptozocin , albuminuria

Diabetes October 2011, Vol.60, 3015-3022. doi:https://doi.org/10.2337/db11-0901

Abrogation of MMP-9 Gene Protects Against the Development of Retinopathy in Diabetic Mice by Preventing Mitochondrial Damage

Renu A. Kowluru; Ghulam Mohammad; Julia M. dos Santos; Qing Zhong

Abstract

View articletitled, Abrogation of MMP-9 Gene Protects Against the Development of Retinopathy in Diabetic Mice by Preventing Mitochondrial Damage

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Topics: diabetic retinopathy , gelatinase b , mice , mitochondria , retina

Diabetes October 2011, Vol.60, 3023-3033. doi:https://doi.org/10.2337/db11-0816

A Novel Cellular Defect in Diabetes: Membrane Repair Failure

Amber C. Howard; Anna K. McNeil; Fei Xiong; Wen-Cheng Xiong; Paul L. McNeil

Abstract

View articletitled, A Novel Cellular Defect in Diabetes: Membrane Repair Failure

Supplementary data

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Topics: dyes , glucose , lasers , mice , rage

Diabetes October 2011, Vol.60, 3034-3043. doi:https://doi.org/10.2337/db11-0851

APPL1 Counteracts Obesity-Induced Vascular Insulin Resistance and Endothelial Dysfunction by Modulating the Endothelial Production of Nitric Oxide and Endothelin-1 in Mice

Yi Wang; Kenneth K.Y. Cheng; Karen S.L. Lam; Donghai Wu; Yu Wang; Yu Huang; Paul M. Vanhoutte; Gary Sweeney; Yiming Li; Aimin Xu

Abstracts

View articletitled, APPL1 Counteracts Obesity-Induced Vascular Insulin Resistance and Endothelial Dysfunction by Modulating the Endothelial Production of Nitric Oxide and Endothelin-1 in Mice

Supplementary data

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Topics: endothelin-1 , insulin , mice , obesity , proto-oncogene proteins c-akt

Diabetes October 2011, Vol.60, 3044-3054. doi:https://doi.org/10.2337/db11-0666

Pharmacology and Therapeutics

Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic Nephropathy

Hongting Zheng; Samantha A. Whitman; Wei Wu; Georg T. Wondrak; Pak K. Wong; Deyu Fang; Donna D. Zhang

Abstracts

View articletitled, Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic Nephropathy

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Topics: diabetic nephropathy , hypertrophy , kidney , streptozocin , mesangial cells

Diabetes October 2011, Vol.60, 3055-3066. doi:https://doi.org/10.2337/db11-0807

Genetics

C-Peptide Response and HLA Genotypes in Subjects With Recent-Onset Type 1 Diabetes After Immunotherapy With DiaPep277: An Exploratory Study

Raffaella Buzzetti; Simona Cernea; Antonio Petrone; Marco Capizzi; Marialuisa Spoletini; Simona Zampetti; Chiara Guglielmi; Chiara Venditti; Paolo Pozzilli; on behalf of the DiaPep Trialists Group

Abstracts

View articletitled, C-Peptide Response and HLA Genotypes in Subjects With Recent-Onset Type 1 Diabetes After Immunotherapy With DiaPep277: An Exploratory Study

Supplementary data

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Topics: child , c-peptide , diabetes mellitus, type 1 , genotype , human leukocyte antigens

Diabetes October 2011, Vol.60, 3067-3072. doi:https://doi.org/10.2337/db10-0560

Genetic Examination of SETD7 and SUV39H1/H2 Methyltransferases and the Risk of Diabetes Complications in Patients With Type 1 Diabetes

Anna Syreeni; Assam El-Osta; Carol Forsblom; Niina Sandholm; Maikki Parkkonen; Lise Tarnow; Hans-Henrik Parving; Amy J. McKnight; Alexander P. Maxwell; Mark E. Cooper; Per-Henrik Groop; on behalf of the FinnDiane Study Group

Abstract

View articletitled, Genetic Examination of SETD7 and SUV39H1/H2 Methyltransferases and the Risk of Diabetes Complications in Patients With Type 1 Diabetes

Supplementary data

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Topics: cardiovascular diseases , diabetes mellitus complications , diabetes mellitus, type 1 , diabetic nephropathy , diabetic retinopathy

Diabetes October 2011, Vol.60, 3073-3080. doi:https://doi.org/10.2337/db11-0073

FUT2 Nonsecretor Status Links Type 1 Diabetes Susceptibility and Resistance to Infection

Deborah J. Smyth; Jason D. Cooper; Joanna M.M. Howson; Pamela Clarke; Kate Downes; Trupti Mistry; Helen Stevens; Neil M. Walker; John A. Todd

Abstracts

View articletitled, FUT2 Nonsecretor Status Links Type 1 Diabetes Susceptibility and Resistance to Infection

Supplementary data

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Topics: diabetes mellitus, type 1 , infections , genotype , alleles

Diabetes October 2011, Vol.60, 3081-3084. doi:https://doi.org/10.2337/db11-0638

CPVL/CHN2 Genetic Variant Is Associated With Diabetic Retinopathy in Chinese Type 2 Diabetic Patients

Cheng Hu; Rong Zhang; Weihui Yu; Jie Wang; Congrong Wang; Can Pang; Xiaojing Ma; Yuqian Bao; Kunsan Xiang; Weiping Jia

Abstract

View articletitled, CPVL/CHN2 Genetic Variant Is Associated With Diabetic Retinopathy in Chinese Type 2 Diabetic Patients

Supplementary data

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Topics: diabetic nephropathy , diabetic retinopathy , kidney diseases , retinal diseases , single nucleotide polymorphism

Diabetes October 2011, Vol.60, 3085-3089. doi:https://doi.org/10.2337/db11-0028

Associations Between Paternally Transmitted Fetal IGF2 Variants and Maternal Circulating Glucose Concentrations in Pregnancy

Clive J. Petry; Rachel V. Seear; Dianne L. Wingate; Lucy Manico; Carlo L. Acerini; Ken K. Ong; Ieuan A. Hughes; David B. Dunger

Abstract

View articletitled, Associations Between Paternally Transmitted Fetal IGF2 Variants and Maternal Circulating Glucose Concentrations in Pregnancy

Supplementary data

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Topics: fetus , glucose , insulin-like growth factor ii , birth weight , haplotypes

Diabetes October 2011, Vol.60, 3090-3096. doi:https://doi.org/10.2337/db11-0689

Erratum

Extract

View articletitled, Erratum

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Topics: abcc8 gene , diazoxide , mutation

Diabetes October 2011, Vol.60, 3097. doi:https://doi.org/10.2337/db11-er11

Issues and Events

Extract

View articletitled, Issues and Events

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Topics: cocos nucifera , country of turkey , florida , turkeys , wisconsin

Diabetes October 2011, Vol.60, 3098. doi:https://doi.org/10.2337/db11-ie11

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