Issues

Topics: artifacts , humor , peer group , personal integrity , plagiarism

Diabetes November 2011, Vol.60, 3099. doi:https://doi.org/10.2337/db11-1127

Commentary

SirT1: A Guardian at the Gates of Adipose Tissue Inflammation

Kae Won Cho; Carey N. Lumeng

Abstracts

Topics: adipose tissue , inflammation , obesity , legal guardians

Diabetes November 2011, Vol.60, 3100-3102. doi:https://doi.org/10.2337/db11-1308

Metabolism

Glucose-Dependent Insulinotropic Polypeptide: A Bifunctional Glucose-Dependent Regulator of Glucagon and Insulin Secretion in Humans

Mikkel Christensen; Louise Vedtofte; Jens J. Holst; Tina Vilsbøll; Filip K. Knop

Abstracts

Topics: glucagon , glucose , insulin , saline solutions , hypoglycemia

Diabetes November 2011, Vol.60, 3103-3109. doi:https://doi.org/10.2337/db11-0979

Elevated Glucose Represses Liver Glucokinase and Induces Its Regulatory Protein to Safeguard Hepatic Phosphate Homeostasis

Catherine Arden; John L. Petrie; Susan J. Tudhope; Ziad Al-Oanzi; Amy J. Claydon; Robert J. Beynon; Howard C. Towle; Loranne Agius

Abstract

Topics: glucose , hepatocytes , metabolites , hyperglycemia , homeostasis

Diabetes November 2011, Vol.60, 3110-3120. doi:https://doi.org/10.2337/db11-0061

Control of Blood Glucose in the Absence of Hepatic Glucose Production During Prolonged Fasting in Mice: Induction of Renal and Intestinal Gluconeogenesis by Glucagon

Elodie Mutel; Amandine Gautier-Stein; Aya Abdul-Wahed; Marta Amigó-Correig; Carine Zitoun; Anne Stefanutti; Isabelle Houberdon; Jean-André Tourette; Gilles Mithieux; Fabienne Rajas

Abstract

Topics: blood glucose , fasting , glucagon , gluconeogenesis , glucose

Diabetes November 2011, Vol.60, 3121-3131. doi:https://doi.org/10.2337/db11-0571

Stimulatory Effect of Insulin on Glucose Uptake by Muscle Involves the Central Nervous System in Insulin-Sensitive Mice

Claudia P. Coomans; Nienke R. Biermasz; Janine J. Geerling; Bruno Guigas; Patrick C.N. Rensen; Louis M. Havekes; Johannes A. Romijn

Abstract

Topics: diet , glucose , glucose uptake , insulin , mice

Diabetes November 2011, Vol.60, 3132-3140. doi:https://doi.org/10.2337/db10-1100

Influence of Hyperinsulinemia and Insulin Resistance on In Vivo β-Cell Function: Their Role in Human β-Cell Dysfunction

Andrea Mari; Andrea Tura; Andrea Natali; Christian Anderwald; Beverley Balkau; Nebojsa Lalic; Mark Walker; Ele Ferrannini; for the RISC Investigators

Abstracts

Topics: c-peptide , glucose , hyperinsulinism , insulin , insulin sensitivity

Diabetes November 2011, Vol.60, 3141-3147. doi:https://doi.org/10.2337/db11-0827

Duodenal PKC-δ and Cholecystokinin Signaling Axis Regulates Glucose Production

Danna M. Breen; Jessica T.Y. Yue; Brittany A. Rasmussen; Andrea Kokorovic; Grace W.C. Cheung; Tony K.T. Lam

Abstract

Topics: duodenum , glucose , infusion procedures , signal transduction , cholecystokinin

Diabetes November 2011, Vol.60, 3148-3153. doi:https://doi.org/10.2337/db11-0852

Modulation of β-Adrenergic Receptors in the Ventromedial Hypothalamus Influences Counterregulatory Responses to Hypoglycemia

Barbara Szepietowska; Wanling Zhu; Owen Chan; Adam Horblitt; James Dziura; Robert S. Sherwin

Abstract

Topics: agonists , antagonists , beta-2 adrenergic receptors , beta-adrenergic receptors , epinephrine

Diabetes November 2011, Vol.60, 3154-3158. doi:https://doi.org/10.2337/db11-0432

Obesity Studies

Deficiency for Costimulatory Receptor 4-1BB Protects Against Obesity-Induced Inflammation and Metabolic Disorders

Chu-Sook Kim; Jae Geun Kim; Byung-Ju Lee; Myung-Sook Choi; Hye-Sun Choi; Teruo Kawada; Ki-Up Lee; Rina Yu

Abstracts

Topics: adipose tissue , cytokine , inflammation , mice , obesity

Diabetes November 2011, Vol.60, 3159-3168. doi:https://doi.org/10.2337/db10-1805

Impaired Expression of the Inducible cAMP Early Repressor Accounts for Sustained Adipose CREB Activity in Obesity

Dimitri Favre; Eric Le Gouill; Denis Fahmi; Chantal Verdumo; Giulia Chinetti-Gbaguidi; Bart Staels; Robert Caiazzo; François Pattou; Kim-Anne Lê; Luc Tappy; Romano Regazzi; Vittorio Giusti; Peter Vollenweider; Gérard Waeber; Amar Abderrahmani

Abstract

Topics: adipocytes , cyclic amp , cyclic amp-responsive dna-binding protein , obesity , polymerase chain reaction

Diabetes November 2011, Vol.60, 3169-3174. doi:https://doi.org/10.2337/db10-1743

Islet Studies

Susceptibility of Glucokinase-MODY Mutants to Inactivation by Oxidative Stress in Pancreatic β-Cells

Kirsty S. Cullen; Franz M. Matschinsky; Loranne Agius; Catherine Arden

Abstracts

Topics: maturity onset diabetes mellitus in young , pancreas

Diabetes November 2011, Vol.60, 3175-3185. doi:https://doi.org/10.2337/db11-0423

Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules

Janine K. Kruit; Nadeeja Wijesekara; Jocelyn E. Manning Fox; Xiao-Qing Dai; Liam R. Brunham; Gavin J. Searle; Garry P. Morgan; Adam J. Costin; Renmei Tang; Alpana Bhattacharjee; James D. Johnson; Peter E. Light; Brad J. Marsh; Patrick E. MacDonald; C. Bruce Verchere; Michael R. Hayden

Abstracts

Topics: abca1 gene , cholesterol , exocytosis , granules , insulin

Diabetes November 2011, Vol.60, 3186-3196. doi:https://doi.org/10.2337/db11-0081

Wld^S Enhances Insulin Transcription and Secretion via a SIRT1-Dependent Pathway and Improves Glucose Homeostasis

Jingxia Wu; Fang Zhang; Menghong Yan; Dongmei Wu; Qiujing Yu; Yi Zhang; Ben Zhou; Michael W. McBurney; Qiwei Zhai

Abstract

Topics: insulin , mice , streptozocin , glucose , bodily secretions

Diabetes November 2011, Vol.60, 3197-3207. doi:https://doi.org/10.2337/db11-0232

Convergence of the Insulin and Serotonin Programs in the Pancreatic β-Cell

Yasuharu Ohta; Yasuhiro Kosaka; Nina Kishimoto; Juehu Wang; Stuart B. Smith; Gerard Honig; Hail Kim; Rosa M. Gasa; Nicole Neubauer; Angela Liou; Laurence H. Tecott; Evan S. Deneris; Michael S. German

Abstracts

Topics: insulin , mice , pancreas , serotonin , rna, messenger

Diabetes November 2011, Vol.60, 3208-3216. doi:https://doi.org/10.2337/db10-1192

Glucagon-Like Peptide 1 Inhibits the Sirtuin Deacetylase SirT1 to Stimulate Pancreatic β-Cell Mass Expansion

Pierre-Olivier Bastien-Dionne; Luca Valenti; Ning Kon; Wei Gu; Jean Buteau

Abstract

Topics: glucagon-like peptide 1 , forkhead box protein o1 , sirtuins , pancreas

Diabetes November 2011, Vol.60, 3217-3222. doi:https://doi.org/10.2337/db11-0101

Immunology and Transplantation

IL-21 Is an Antitolerogenic Cytokine of the Late-Phase Alloimmune Response

Alessandra Petrelli; Michele Carvello; Andrea Vergani; Kang Mi Lee; Sara Tezza; Ming Du; Sonja Kleffel; Liu Chengwen; Bechara G. Mfarrej; Patrick Hwu; Antonio Secchi; Warren J. Leonard; Deborah Young; Mohamed H. Sayegh; James F. Markmann; Allan J. Zajac; Paolo Fiorina

Abstract

Topics: interleukin-21 , mice , regulatory t-lymphocytes

Diabetes November 2011, Vol.60, 3223-3234. doi:https://doi.org/10.2337/db11-0880

Pathophysiology

SirT1 Regulates Adipose Tissue Inflammation

Matthew P. Gillum; Maya E. Kotas; Derek M. Erion; Romy Kursawe; Paula Chatterjee; Kevin T. Nead; Eric S. Muise; Jennifer J. Hsiao; David W. Frederick; Shin Yonemitsu; Alexander S. Banks; Li Qiang; Sanjay Bhanot; Jerrold M. Olefsky; Dorothy D. Sears; Sonia Caprio; Gerald I. Shulman

Abstracts

Topics: adipose tissue , inflammation , macrophages , obesity , cytokine

Diabetes November 2011, Vol.60, 3235-3245. doi:https://doi.org/10.2337/db11-0616

Early Treatment of NOD Mice With B7-H4 Reduces the Incidence of Autoimmune Diabetes

Xiaojie Wang; Jianqiang Hao; Daniel L. Metzger; Alice Mui; Ziliang Ao; Noushin Akhoundsadegh; Solomon Langermann; Linda Liu; Lieping Chen; Dawei Ou; C. Bruce Verchere; Garth L. Warnock

Abstract

Topics: autoimmunity , immunoglobulins , mice , mice, inbred nod , t-lymphocytes

Diabetes November 2011, Vol.60, 3246-3255. doi:https://doi.org/10.2337/db11-0375

Complications

Brain Activation During Working Memory Is Altered in Patients With Type 1 Diabetes During Hypoglycemia

Nicolas R. Bolo; Gail Musen; Alan M. Jacobson; Katie Weinger; Richard L. McCartney; Veronica Flores; Perry F. Renshaw; Donald C. Simonson

Abstract

Topics: brain , diabetes mellitus, type 1 , hypoglycemia , blood glucose normal , blood oxygen level dependent

Diabetes November 2011, Vol.60, 3256-3264. doi:https://doi.org/10.2337/db11-0506

Decreased IRS2 and TIMP3 Expression in Monocytes From Offspring of Type 2 Diabetic Patients Is Correlated With Insulin Resistance and Increased Intima-Media Thickness

Marina Cardellini; Rossella Menghini; Alessio Luzi; Francesca Davato; Iris Cardolini; Rossella D'Alfonso; Paolo Gentileschi; Stefano Rizza; Maria Adelaide Marini; Ottavia Porzio; Davide Lauro; Paolo Sbraccia; Renato Lauro; Massimo Federici

Abstract

Topics: atherosclerosis , insulin , insulin resistance , irs2 protein, human , monocytes

Diabetes November 2011, Vol.60, 3265-3270. doi:https://doi.org/10.2337/db11-0162

Pharmacology and Therapeutics

Effect of Rosiglitazone on Bone Quality in a Rat Model of Insulin Resistance and Osteoporosis

Laura D. Sardone; Richard Renlund; Thomas L. Willett; Ivan G. Fantus; Marc D. Grynpas

Abstract

Topics: bone remodeling , bone resorption , compact bone , diabetes mellitus, type 2 , fractures

Diabetes November 2011, Vol.60, 3271-3278. doi:https://doi.org/10.2337/db10-1672

Genetics

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic β-Cell Apoptosis via Regulation of the BH3-Only Protein Bim

Izortze Santin; Fabrice Moore; Maikel L. Colli; Esteban N. Gurzov; Lorella Marselli; Piero Marchetti; Decio L. Eizirik

Abstract

Topics: apoptosis , cytokine , candidate disease gene , diabetes mellitus, type 1 , western blotting

Diabetes November 2011, Vol.60, 3279-3288. doi:https://doi.org/10.2337/db11-0758

Single Insulin-Specific CD8⁺ T Cells Show Characteristic Gene Expression Profiles in Human Type 1 Diabetes

Sandrine Luce; François Lemonnier; Jean-Paul Briand; Joel Coste; Najiba Lahlou; Sylviane Muller; Etienne Larger; Benedita Rocha; Roberto Mallone; Christian Boitard

Abstract

Topics: diabetes mellitus, type 1 , insulin , peptides , proton pump inhibitors , t-lymphocytes

Diabetes November 2011, Vol.60, 3289-3299. doi:https://doi.org/10.2337/db11-0270

Cesarean Section and Interferon-Induced Helicase Gene Polymorphisms Combine to Increase Childhood Type 1 Diabetes Risk

Ezio Bonifacio; Katharina Warncke; Christiane Winkler; Maike Wallner; Anette-G. Ziegler

Abstract

Topics: cesarean section , child , diabetes mellitus, type 1 , genes , autoantibodies

Diabetes November 2011, Vol.60, 3300-3306. doi:https://doi.org/10.2337/db11-0729

Errata

Erratum

Extract

Topics: diabetes mellitus, type 1 , emergency service, hospital , white matter

Diabetes November 2011, Vol.60, 3307. doi:https://doi.org/10.2337/db11-er12a

Erratum

Extract

Topics: glucagon secretion , insulin , reactive oxygen species , uncoupling protein 2

Diabetes November 2011, Vol.60, 3307. doi:https://doi.org/10.2337/db11-er12b

Erratum

Extract

Topics: diet , fat metabolism , genetics , glucose , leptin

Diabetes November 2011, Vol.60, 3307. doi:https://doi.org/10.2337/db11-er12c

Erratum

Extract

Topics: alleles , haplotypes , human leukocyte antigens , proband , diabetes mellitus, type 1

Diabetes November 2011, Vol.60, 3308-3310. doi:https://doi.org/10.2337/db11-er12

Issues and Events

Extract