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Volume 60, Issue 12
1 December 2011
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ISSN 0012-1797
EISSN 1939-327X
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Editorial

Farewell Statement From Dr. Peter Butler as Outgoing Editor in Chief of Diabetes
Peter C. Butler
View articletitled, Farewell Statement From Dr. Peter Butler as Outgoing Editor in Chief of <em>Diabetes</em>
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Diabetes November 2011, Vol.60, 3099. doi:https://doi.org/10.2337/db11-1127

Commentary

SirT1: A Guardian at the Gates of Adipose Tissue Inflammation
Kae Won Cho; Carey N. Lumeng
View articletitled, SirT1: A Guardian at the Gates of Adipose Tissue Inflammation
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Diabetes November 2011, Vol.60, 3100-3102. doi:https://doi.org/10.2337/db11-1308

Metabolism

Glucose-Dependent Insulinotropic Polypeptide: A Bifunctional Glucose-Dependent Regulator of Glucagon and Insulin Secretion in Humans
Mikkel Christensen; Louise Vedtofte; Jens J. Holst; Tina Vilsbøll; Filip K. Knop
View articletitled, Glucose-Dependent Insulinotropic Polypeptide<span class="subtitle-colon">: </span><span class="subtitle">A Bifunctional Glucose-Dependent Regulator of Glucagon and Insulin Secretion in Humans</span>
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Diabetes November 2011, Vol.60, 3103-3109. doi:https://doi.org/10.2337/db11-0979
Elevated Glucose Represses Liver Glucokinase and Induces Its Regulatory Protein to Safeguard Hepatic Phosphate Homeostasis
Catherine Arden; John L. Petrie; Susan J. Tudhope; Ziad Al-Oanzi; Amy J. Claydon; Robert J. Beynon; Howard C. Towle; Loranne Agius
View articletitled, Elevated Glucose Represses Liver Glucokinase and Induces Its Regulatory Protein to Safeguard Hepatic Phosphate Homeostasis
Supplementary data
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Diabetes November 2011, Vol.60, 3110-3120. doi:https://doi.org/10.2337/db11-0061
Control of Blood Glucose in the Absence of Hepatic Glucose Production During Prolonged Fasting in Mice: Induction of Renal and Intestinal Gluconeogenesis by Glucagon
Elodie Mutel; Amandine Gautier-Stein; Aya Abdul-Wahed; Marta Amigó-Correig; Carine Zitoun; Anne Stefanutti; Isabelle Houberdon; Jean-André Tourette; Gilles Mithieux; Fabienne Rajas
View articletitled, Control of Blood Glucose in the Absence of Hepatic Glucose Production During Prolonged Fasting in Mice<span class="subtitle-colon">: </span><span class="subtitle">Induction of Renal and Intestinal Gluconeogenesis by Glucagon</span>
Supplementary data
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Diabetes November 2011, Vol.60, 3121-3131. doi:https://doi.org/10.2337/db11-0571
Stimulatory Effect of Insulin on Glucose Uptake by Muscle Involves the Central Nervous System in Insulin-Sensitive Mice
Claudia P. Coomans; Nienke R. Biermasz; Janine J. Geerling; Bruno Guigas; Patrick C.N. Rensen; Louis M. Havekes; Johannes A. Romijn
View articletitled, Stimulatory Effect of Insulin on Glucose Uptake by Muscle Involves the Central Nervous System in Insulin-Sensitive Mice
Supplementary data
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Diabetes November 2011, Vol.60, 3132-3140. doi:https://doi.org/10.2337/db10-1100
Influence of Hyperinsulinemia and Insulin Resistance on In Vivo β-Cell Function: Their Role in Human β-Cell Dysfunction
Andrea Mari; Andrea Tura; Andrea Natali; Christian Anderwald; Beverley Balkau; Nebojsa Lalic; Mark Walker; Ele Ferrannini; for the RISC Investigators
View articletitled, Influence of Hyperinsulinemia and Insulin Resistance on In Vivo β-Cell Function<span class="subtitle-colon">: </span><span class="subtitle">Their Role in Human β-Cell Dysfunction</span>
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Diabetes November 2011, Vol.60, 3141-3147. doi:https://doi.org/10.2337/db11-0827
Duodenal PKC-δ and Cholecystokinin Signaling Axis Regulates Glucose Production
Danna M. Breen; Jessica T.Y. Yue; Brittany A. Rasmussen; Andrea Kokorovic; Grace W.C. Cheung; Tony K.T. Lam
View articletitled, Duodenal PKC-δ and Cholecystokinin Signaling Axis Regulates Glucose Production
Supplementary data
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Diabetes November 2011, Vol.60, 3148-3153. doi:https://doi.org/10.2337/db11-0852
Modulation of β-Adrenergic Receptors in the Ventromedial Hypothalamus Influences Counterregulatory Responses to Hypoglycemia
Barbara Szepietowska; Wanling Zhu; Owen Chan; Adam Horblitt; James Dziura; Robert S. Sherwin
View articletitled, Modulation of β-Adrenergic Receptors in the Ventromedial Hypothalamus Influences Counterregulatory Responses to Hypoglycemia
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Diabetes November 2011, Vol.60, 3154-3158. doi:https://doi.org/10.2337/db11-0432

Obesity Studies

Deficiency for Costimulatory Receptor 4-1BB Protects Against Obesity-Induced Inflammation and Metabolic Disorders
Chu-Sook Kim; Jae Geun Kim; Byung-Ju Lee; Myung-Sook Choi; Hye-Sun Choi; Teruo Kawada; Ki-Up Lee; Rina Yu
View articletitled, Deficiency for Costimulatory Receptor 4-1BB Protects Against Obesity-Induced Inflammation and Metabolic Disorders
Supplementary data
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Diabetes November 2011, Vol.60, 3159-3168. doi:https://doi.org/10.2337/db10-1805
Impaired Expression of the Inducible cAMP Early Repressor Accounts for Sustained Adipose CREB Activity in Obesity
Dimitri Favre; Eric Le Gouill; Denis Fahmi; Chantal Verdumo; Giulia Chinetti-Gbaguidi; Bart Staels; Robert Caiazzo; François Pattou; Kim-Anne Lê; Luc Tappy; Romano Regazzi; Vittorio Giusti; Peter Vollenweider; Gérard Waeber; Amar Abderrahmani
View articletitled, Impaired Expression of the Inducible cAMP Early Repressor Accounts for Sustained Adipose CREB Activity in Obesity
Supplementary data
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Diabetes November 2011, Vol.60, 3169-3174. doi:https://doi.org/10.2337/db10-1743

Islet Studies

Susceptibility of Glucokinase-MODY Mutants to Inactivation by Oxidative Stress in Pancreatic β-Cells
Kirsty S. Cullen; Franz M. Matschinsky; Loranne Agius; Catherine Arden
View articletitled, Susceptibility of Glucokinase-MODY Mutants to Inactivation by Oxidative Stress in Pancreatic β-Cells
Supplementary data
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Diabetes November 2011, Vol.60, 3175-3185. doi:https://doi.org/10.2337/db11-0423
Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules
Janine K. Kruit; Nadeeja Wijesekara; Jocelyn E. Manning Fox; Xiao-Qing Dai; Liam R. Brunham; Gavin J. Searle; Garry P. Morgan; Adam J. Costin; Renmei Tang; Alpana Bhattacharjee; James D. Johnson; Peter E. Light; Brad J. Marsh; Patrick E. MacDonald; C. Bruce Verchere; Michael R. Hayden
View articletitled, Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules
Supplementary data
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Diabetes November 2011, Vol.60, 3186-3196. doi:https://doi.org/10.2337/db11-0081
WldS Enhances Insulin Transcription and Secretion via a SIRT1-Dependent Pathway and Improves Glucose Homeostasis
Jingxia Wu; Fang Zhang; Menghong Yan; Dongmei Wu; Qiujing Yu; Yi Zhang; Ben Zhou; Michael W. McBurney; Qiwei Zhai
View articletitled, Wld<sup>S</sup> Enhances Insulin Transcription and Secretion via a SIRT1-Dependent Pathway and Improves Glucose Homeostasis
Supplementary data
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Diabetes November 2011, Vol.60, 3197-3207. doi:https://doi.org/10.2337/db11-0232
Convergence of the Insulin and Serotonin Programs in the Pancreatic β-Cell
Yasuharu Ohta; Yasuhiro Kosaka; Nina Kishimoto; Juehu Wang; Stuart B. Smith; Gerard Honig; Hail Kim; Rosa M. Gasa; Nicole Neubauer; Angela Liou; Laurence H. Tecott; Evan S. Deneris; Michael S. German
View articletitled, Convergence of the Insulin and Serotonin Programs in the Pancreatic β-Cell
Supplementary data
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Diabetes November 2011, Vol.60, 3208-3216. doi:https://doi.org/10.2337/db10-1192
Glucagon-Like Peptide 1 Inhibits the Sirtuin Deacetylase SirT1 to Stimulate Pancreatic β-Cell Mass Expansion
Pierre-Olivier Bastien-Dionne; Luca Valenti; Ning Kon; Wei Gu; Jean Buteau
View articletitled, Glucagon-Like Peptide 1 Inhibits the Sirtuin Deacetylase SirT1 to Stimulate Pancreatic β-Cell Mass Expansion
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Diabetes November 2011, Vol.60, 3217-3222. doi:https://doi.org/10.2337/db11-0101

Immunology and Transplantation

IL-21 Is an Antitolerogenic Cytokine of the Late-Phase Alloimmune Response
Alessandra Petrelli; Michele Carvello; Andrea Vergani; Kang Mi Lee; Sara Tezza; Ming Du; Sonja Kleffel; Liu Chengwen; Bechara G. Mfarrej; Patrick Hwu; Antonio Secchi; Warren J. Leonard; Deborah Young; Mohamed H. Sayegh; James F. Markmann; Allan J. Zajac; Paolo Fiorina
View articletitled, IL-21 Is an Antitolerogenic Cytokine of the Late-Phase Alloimmune Response
Supplementary data
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Diabetes November 2011, Vol.60, 3223-3234. doi:https://doi.org/10.2337/db11-0880

Pathophysiology

SirT1 Regulates Adipose Tissue Inflammation
Matthew P. Gillum; Maya E. Kotas; Derek M. Erion; Romy Kursawe; Paula Chatterjee; Kevin T. Nead; Eric S. Muise; Jennifer J. Hsiao; David W. Frederick; Shin Yonemitsu; Alexander S. Banks; Li Qiang; Sanjay Bhanot; Jerrold M. Olefsky; Dorothy D. Sears; Sonia Caprio; Gerald I. Shulman
View articletitled, SirT1 Regulates Adipose Tissue Inflammation
Supplementary data
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Diabetes November 2011, Vol.60, 3235-3245. doi:https://doi.org/10.2337/db11-0616
Early Treatment of NOD Mice With B7-H4 Reduces the Incidence of Autoimmune Diabetes
Xiaojie Wang; Jianqiang Hao; Daniel L. Metzger; Alice Mui; Ziliang Ao; Noushin Akhoundsadegh; Solomon Langermann; Linda Liu; Lieping Chen; Dawei Ou; C. Bruce Verchere; Garth L. Warnock
View articletitled, Early Treatment of NOD Mice With B7-H4 Reduces the Incidence of Autoimmune Diabetes
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Diabetes November 2011, Vol.60, 3246-3255. doi:https://doi.org/10.2337/db11-0375

Complications

Brain Activation During Working Memory Is Altered in Patients With Type 1 Diabetes During Hypoglycemia
Nicolas R. Bolo; Gail Musen; Alan M. Jacobson; Katie Weinger; Richard L. McCartney; Veronica Flores; Perry F. Renshaw; Donald C. Simonson
View articletitled, Brain Activation During Working Memory Is Altered in Patients With Type 1 Diabetes During Hypoglycemia
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Diabetes November 2011, Vol.60, 3256-3264. doi:https://doi.org/10.2337/db11-0506
Decreased IRS2 and TIMP3 Expression in Monocytes From Offspring of Type 2 Diabetic Patients Is Correlated With Insulin Resistance and Increased Intima-Media Thickness
Marina Cardellini; Rossella Menghini; Alessio Luzi; Francesca Davato; Iris Cardolini; Rossella D'Alfonso; Paolo Gentileschi; Stefano Rizza; Maria Adelaide Marini; Ottavia Porzio; Davide Lauro; Paolo Sbraccia; Renato Lauro; Massimo Federici
View articletitled, Decreased IRS2 and TIMP3 Expression in Monocytes From Offspring of Type 2 Diabetic Patients Is Correlated With Insulin Resistance and Increased Intima-Media Thickness
Supplementary data
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Diabetes November 2011, Vol.60, 3265-3270. doi:https://doi.org/10.2337/db11-0162

Pharmacology and Therapeutics

Effect of Rosiglitazone on Bone Quality in a Rat Model of Insulin Resistance and Osteoporosis
Laura D. Sardone; Richard Renlund; Thomas L. Willett; Ivan G. Fantus; Marc D. Grynpas
View articletitled, Effect of Rosiglitazone on Bone Quality in a Rat Model of Insulin Resistance and Osteoporosis
Supplementary data
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Diabetes November 2011, Vol.60, 3271-3278. doi:https://doi.org/10.2337/db10-1672

Genetics

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic β-Cell Apoptosis via Regulation of the BH3-Only Protein Bim
Izortze Santin; Fabrice Moore; Maikel L. Colli; Esteban N. Gurzov; Lorella Marselli; Piero Marchetti; Decio L. Eizirik
View articletitled, <em>PTPN2</em>, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic β-Cell Apoptosis via Regulation of the BH3-Only Protein Bim
Supplementary data
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Diabetes November 2011, Vol.60, 3279-3288. doi:https://doi.org/10.2337/db11-0758
Single Insulin-Specific CD8+ T Cells Show Characteristic Gene Expression Profiles in Human Type 1 Diabetes
Sandrine Luce; François Lemonnier; Jean-Paul Briand; Joel Coste; Najiba Lahlou; Sylviane Muller; Etienne Larger; Benedita Rocha; Roberto Mallone; Christian Boitard
View articletitled, Single Insulin-Specific CD8<sup>+</sup> T Cells Show Characteristic Gene Expression Profiles in Human Type 1 Diabetes
Supplementary data
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Diabetes November 2011, Vol.60, 3289-3299. doi:https://doi.org/10.2337/db11-0270
Cesarean Section and Interferon-Induced Helicase Gene Polymorphisms Combine to Increase Childhood Type 1 Diabetes Risk
Ezio Bonifacio; Katharina Warncke; Christiane Winkler; Maike Wallner; Anette-G. Ziegler
View articletitled, Cesarean Section and Interferon-Induced Helicase Gene Polymorphisms Combine to Increase Childhood Type 1 Diabetes Risk
Supplementary data
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Diabetes November 2011, Vol.60, 3300-3306. doi:https://doi.org/10.2337/db11-0729

Errata

Erratum
View articletitled, Erratum
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Diabetes November 2011, Vol.60, 3307. doi:https://doi.org/10.2337/db11-er12a
Erratum
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Diabetes November 2011, Vol.60, 3307. doi:https://doi.org/10.2337/db11-er12b
Erratum
View articletitled, Erratum
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Diabetes November 2011, Vol.60, 3307. doi:https://doi.org/10.2337/db11-er12c
Erratum
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Diabetes November 2011, Vol.60, 3308-3310. doi:https://doi.org/10.2337/db11-er12

Issues and Events

Issues and Events
View articletitled, Issues and Events
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Diabetes November 2011, Vol.60, 3311. doi:https://doi.org/10.2337/db11-ie12
Système International (SI) Units Table
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
300-OR: Beneficial Effect of the Combination Therapy of Cagrilintide, a Dual Amylin/Calcitonin Agonist, and Tirzepatide, a Dual GLP-1/GIP Agonist, on Body Weight Loss in Obese Rats
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
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