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1 February 2011
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ISSN 0012-1797
EISSN 1939-327X
In this Issue
Editorial
It's Time to Consider Changing the Rules: The Rationale for Rethinking Control Groups in Clinical Trials Aimed at Reversing Type 1 Diabetes
Diabetes January 2011, Vol.60, 361-363. doi:https://doi.org/10.2337/db10-1506
Perspectives in Diabetes
Historical Perspective: Beginnings of the β-Cell: Current Perspectives in β-Cell Development
Diabetes January 2011, Vol.60, 364-376. doi:https://doi.org/10.2337/db10-1068
Commentaries
A Therapeutic Insight in β-Cell Imaging?
Diabetes January 2011, Vol.60, 381-382. doi:https://doi.org/10.2337/db10-1591
Metabolism
Effects of Acute Hyperglucagonemia on Hepatic and Intestinal Lipoprotein Production and Clearance in Healthy Humans
Diabetes January 2011, Vol.60, 383-390. doi:https://doi.org/10.2337/db10-0763
Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice
Diabetes January 2011, Vol.60, 391-397. doi:https://doi.org/10.2337/db10-0426
Hepatic Glycogen Supercompensation Activates AMP-Activated Protein Kinase, Impairs Insulin Signaling, and Reduces Glycogen Deposition in the Liver
Jason J. Winnick; Zhibo An; Christopher J. Ramnanan; Marta Smith; Jose M. Irimia; Doss W. Neal; Mary Courtney Moore; Peter J. Roach; Alan D. Cherrington
Diabetes January 2011, Vol.60, 398-407. doi:https://doi.org/10.2337/db10-0592
Normal Postprandial Nonesterified Fatty Acid Uptake in Muscles Despite Increased Circulating Fatty Acids in Type 2 Diabetes
Sébastien M. Labbé; Etienne Croteau; Thomas Grenier-Larouche; Frédérique Frisch; René Ouellet; Réjean Langlois; Brigitte Guérin; Eric E. Turcotte; André C. Carpentier
Diabetes January 2011, Vol.60, 408-415. doi:https://doi.org/10.2337/db10-0997
Diet-Induced Muscle Insulin Resistance Is Associated With Extracellular Matrix Remodeling and Interaction With Integrin α2β1 in Mice
Li Kang; Julio E. Ayala; Robert S. Lee-Young; Zhonghua Zhang; Freyja D. James; P. Darrell Neufer; Ambra Pozzi; Mary M. Zutter; David H. Wasserman
Diabetes January 2011, Vol.60, 416-426. doi:https://doi.org/10.2337/db10-1116
The Adipocyte-Expressed Forkhead Transcription Factor Foxc2 Regulates Metabolism Through Altered Mitochondrial Function
Martin E. Lidell; Erin L. Seifert; Rickard Westergren; Mikael Heglind; Adrienne Gowing; Valentina Sukonina; Zahra Arani; Paula Itkonen; Simonetta Wallin; Fredrik Westberg; Julia Fernandez-Rodriguez; Markku Laakso; Tommy Nilsson; Xiao-Rong Peng; Mary-Ellen Harper; Sven Enerbäck
Diabetes January 2011, Vol.60, 427-435. doi:https://doi.org/10.2337/db10-0409
Participation of Hindbrain AMP-Activated Protein Kinase in Glucoprivic Feeding
Diabetes January 2011, Vol.60, 436-442. doi:https://doi.org/10.2337/db10-0352
Effects of Insulin on Brain Glucose Metabolism in Impaired Glucose Tolerance
Jussi Hirvonen; Kirsi A. Virtanen; Lauri Nummenmaa; Jarna C. Hannukainen; Miikka-Juhani Honka; Marco Bucci; Sergey V. Nesterov; Riitta Parkkola; Juha Rinne; Patricia Iozzo; Pirjo Nuutila
Diabetes January 2011, Vol.60, 443-447. doi:https://doi.org/10.2337/db10-0940
Distinct Roles of Endothelial and Adipocyte Caveolin-1 in Macrophage Infiltration and Adipose Tissue Metabolic Activity
Diabetes January 2011, Vol.60, 448-453. doi:https://doi.org/10.2337/db10-0856
Signal Transduction
Phosphatidylinositol-4-Phosphate-5-Kinase α Deficiency Alters Dynamics of Glucose-Stimulated Insulin Release to Improve Glucohomeostasis and Decrease Obesity in Mice
Ping Huang; Oladapo Yeku; Haihong Zong; Phyllis Tsang; Wenjuan Su; Xiao Yu; Shuzhi Teng; Mary Osisami; Yasunori Kanaho; Jeffrey E. Pessin; Michael A. Frohman
Diabetes January 2011, Vol.60, 454-463. doi:https://doi.org/10.2337/db10-0614
Obesity Studies
Smad3 Deficiency in Mice Protects Against Insulin Resistance and Obesity Induced by a High-Fat Diet
Chek Kun Tan; Nicolas Leuenberger; Ming Jie Tan; Yew Wai Yan; Yinghui Chen; Ravi Kambadur; Walter Wahli; Nguan Soon Tan
Diabetes January 2011, Vol.60, 464-476. doi:https://doi.org/10.2337/db10-0801
Effects of Metformin on Body Weight and Body Composition in Obese Insulin-Resistant Children: A Randomized Clinical Trial
Jack A. Yanovski; Jonathan Krakoff; Christine G. Salaita; Jennifer R. McDuffie; Merel Kozlosky; Nancy G. Sebring; James C. Reynolds; Sheila M. Brady; Karim A. Calis
Diabetes January 2011, Vol.60, 477-485. doi:https://doi.org/10.2337/db10-1185
Selective Inactivation of c-Jun NH2-Terminal Kinase in Adipose Tissue Protects Against Diet-Induced Obesity and Improves Insulin Sensitivity in Both Liver and Skeletal Muscle in Mice
Xinmei Zhang; Aimin Xu; Sookja K. Chung; Justin H.B. Cresser; Gary Sweeney; Rachel L.C. Wong; Anning Lin; Karen S.L. Lam
Diabetes January 2011, Vol.60, 486-495. doi:https://doi.org/10.2337/db10-0650
A Newly Identified CG301269 Improves Lipid and Glucose Metabolism Without Body Weight Gain Through Activation of Peroxisome Proliferator–Activated Receptor α and γ
Hyun Woo Jeong; Joo-Won Lee; Woo Sik Kim; Sung Sik Choe; Kyung-Hee Kim; Ho Seon Park; Hyun Jung Shin; Gha Young Lee; Dongkyu Shin; Hanjae Lee; Jun Hee Lee; Eun Bok Choi; Hyeon Kyu Lee; Heekyoung Chung; Seung Bum Park; Kyong Soo Park; Hyo-Soo Kim; Seonggu Ro; Jae Bum Kim
Diabetes January 2011, Vol.60, 496-506. doi:https://doi.org/10.2337/db09-1145
Hypoxia-Induced Intrauterine Growth Restriction Increases the Susceptibility of Rats to High-Fat Diet–Induced Metabolic Syndrome
Christian F. Rueda-Clausen; Vernon W. Dolinsky; Jude S. Morton; Spencer D. Proctor; Jason R.B. Dyck; Sandra T. Davidge
Diabetes January 2011, Vol.60, 507-516. doi:https://doi.org/10.2337/db10-1239
Hyperglycemia Activates Caspase-1 and TXNIP-Mediated IL-1β Transcription in Human Adipose Tissue
Tim B. Koenen; Rinke Stienstra; Lambertus J. van Tits; Jacqueline de Graaf; Anton F.H. Stalenhoef; Leo A.B. Joosten; Cees J. Tack; Mihai G. Netea
Diabetes January 2011, Vol.60, 517-524. doi:https://doi.org/10.2337/db10-0266
Islet Studies
Disruption of Hepatocyte Growth Factor/c-Met Signaling Enhances Pancreatic β-Cell Death and Accelerates the Onset of Diabetes
Jose Mellado-Gil; Taylor C. Rosa; Cem Demirci; Jose A. Gonzalez-Pertusa; Silvia Velazquez-Garcia; Sara Ernst; Shelley Valle; Rupangi C. Vasavada; Andrew F. Stewart; Laura C. Alonso; Adolfo Garcia-Ocaña
Diabetes January 2011, Vol.60, 525-536. doi:https://doi.org/10.2337/db09-1305
Interleukin-6 Enhances Glucose-Stimulated Insulin Secretion From Pancreatic β-Cells: Potential Involvement of the PLC-IP3–Dependent Pathway
Toshinobu Suzuki; Junta Imai; Tetsuya Yamada; Yasushi Ishigaki; Keizo Kaneko; Kenji Uno; Yutaka Hasegawa; Hisamitsu Ishihara; Yoshitomo Oka; Hideki Katagiri
Diabetes January 2011, Vol.60, 537-547. doi:https://doi.org/10.2337/db10-0796
The Expression and Function of Glucose-Dependent Insulinotropic Polypeptide in the Embryonic Mouse Pancreas
Krishna Prasadan; Masayuki Koizumi; Sidhartha Tulachan; Chiyo Shiota; Nikesh Lath; Jose Paredes; Ping Guo; Yousef El-Gohary; Marcus Malek; Sohail Shah; George K. Gittes
Diabetes January 2011, Vol.60, 548-554. doi:https://doi.org/10.2337/db09-0035
Immunology and Transplantation
Induction of Mixed Chimerism With MHC-Mismatched but Not Matched Bone Marrow Transplants Results in Thymic Deletion of Host-Type Autoreactive T-Cells in NOD Mice
Jeremy Racine; Miao Wang; Chunyan Zhang; Chia-Lei Lin; Hongjun Liu; Ivan Todorov; Mark Atkinson; Defu Zeng
Diabetes January 2011, Vol.60, 555-564. doi:https://doi.org/10.2337/db10-0827
Combined Small Interfering RNA Therapy and In Vivo Magnetic Resonance Imaging in Islet Transplantation
Ping Wang; Mehmet V. Yigit; Zdravka Medarova; Lingling Wei; Guangping Dai; Christian Schuetz; Anna Moore
Diabetes January 2011, Vol.60, 565-571. doi:https://doi.org/10.2337/db10-1400
Pathophysiology
Reduction in Basal Nitric Oxide Activity Causes Albuminuria
Diabetes January 2011, Vol.60, 572-576. doi:https://doi.org/10.2337/db09-1630
Thirty Years of Prospective Nationwide Incidence of Childhood Type 1 Diabetes: The Accelerating Increase by Time Tends to Level Off in Sweden
Yonas Berhan; Ingeborg Waernbaum; Torbjörn Lind; Anna Möllsten; Gisela Dahlquist; for the Swedish Childhood Diabetes Study Group*
Diabetes January 2011, Vol.60, 577-581. doi:https://doi.org/10.2337/db10-0813
Complications
Levels of Oxidized LDL and Advanced Glycation End Products–Modified LDL in Circulating Immune Complexes Are Strongly Associated With Increased Levels of Carotid Intima-Media Thickness and Its Progression in Type 1 Diabetes
Maria F. Lopes-Virella; Kelly J. Hunt; Nathaniel L. Baker; John Lachin; David M. Nathan; G. Virella; the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group
Diabetes January 2011, Vol.60, 582-589. doi:https://doi.org/10.2337/db10-0915
The Protective Role of Smad7 in Diabetic Kidney Disease: Mechanism and Therapeutic Potential
Hai Yong Chen; Xiao R. Huang; Wansheng Wang; Jin Hua Li; Rainer L. Heuchel; Arthur C.K. Chung; Hui Yao Lan
Diabetes January 2011, Vol.60, 590-601. doi:https://doi.org/10.2337/db10-0403
Adrenergic Mediation of Hypoglycemia-Associated Autonomic Failure
Diabetes January 2011, Vol.60, 602-606. doi:https://doi.org/10.2337/db10-1374
Progression of Carotid Artery Intima-Media Thickness During 12 Years in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study
Joseph F. Polak; Jye-Yu C. Backlund; Patricia A. Cleary; Anita P. Harrington; Daniel H. O’Leary; John M. Lachin; David M. Nathan; for the DCCT/EDIC Research Group
Diabetes January 2011, Vol.60, 607-613. doi:https://doi.org/10.2337/db10-0296
Increased Expression and Activity of 12-Lipoxygenase in Oxygen-Induced Ischemic Retinopathy and Proliferative Diabetic Retinopathy: Implications in Retinal Neovascularization
Mohamed Al-Shabrawey; Rene Mussell; Khalid Kahook; Amany Tawfik; Mohamed Eladl; Vijay Sarthy; Julian Nussbaum; Ahmed El-Marakby; Sun Young Park; Zafer Gurel; Nader Sheibani; Krishna Rao Maddipati
Diabetes January 2011, Vol.60, 614-624. doi:https://doi.org/10.2337/db10-0008
Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress–Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo
Yi Tan; Tomonaga Ichikawa; Jinqing Li; Qiusheng Si; Huaitao Yang; Xiangbai Chen; Curtis S. Goldblatt; Colin J. Meyer; Xiaokun Li; Lu Cai; Taixing Cui
Diabetes January 2011, Vol.60, 625-633. doi:https://doi.org/10.2337/db10-1164
Pharmacology and Therapeutics
Selective Reversible Inhibition of Liver Carnitine Palmitoyl-Transferase 1 by Teglicar Reduces Gluconeogenesis and Improves Glucose Homeostasis
Roberto Conti; Edoardo Mannucci; Pompeo Pessotto; Emanuela Tassoni; Paolo Carminati; Fabio Giannessi; Arduino Arduini
Diabetes January 2011, Vol.60, 644-651. doi:https://doi.org/10.2337/db10-0346
Adiponectin Pretreatment Counteracts the Detrimental Effect of a Diabetic Environment on Endothelial Progenitors
Simon F. Leicht; Theresa M. Schwarz; Patrick C. Hermann; Jochen Seissler; Alexandra Aicher; Christopher Heeschen
Diabetes January 2011, Vol.60, 652-661. doi:https://doi.org/10.2337/db10-0240
Genetics
Resequencing and Analysis of Variation in the TCF7L2 Gene in African Americans Suggests That SNP rs7903146 Is the Causal Diabetes Susceptibility Variant
Nicholette D. Palmer; Jessica M. Hester; S. Sandy An; Adebowale Adeyemo; Charles Rotimi; Carl D. Langefeld; Barry I. Freedman; Maggie C.Y. Ng; Donald W. Bowden
Diabetes January 2011, Vol.60, 662-668. doi:https://doi.org/10.2337/db10-0134
Links Between Insulin Resistance, Adenosine A2B Receptors, and Inflammatory Markers in Mice and Humans
Robert A. Figler; Guoquan Wang; Susseela Srinivasan; Dae Young Jung; Zhiyou Zhang; James S. Pankow; Katya Ravid; Bertil Fredholm; Catherine C. Hedrick; Stephen S. Rich; Jason K. Kim; Kathryn F. LaNoue; Joel Linden
Diabetes January 2011, Vol.60, 669-679. doi:https://doi.org/10.2337/db10-1070
The Same Chromosome 9p21.3 Locus Is Associated With Type 2 Diabetes and Coronary Artery Disease in a Chinese Han Population
Xiang Cheng; Lisong Shi; Shaofang Nie; Fan Wang; Xiuchun Li; Chengqi Xu; Pengyun Wang; Baofeng Yang; Qingxian Li; Zhenwei Pan; Yue Li; Hao Xia; Chenhong Zheng; Yuhe Ke; Yanxia Wu; Tingting Tang; Xinxin Yan; Yan Yang; Ni Xia; Rui Yao; Binbin Wang; Xu Ma; Qiutang Zeng; Xin Tu; Yuhua Liao; Qing K. Wang
Diabetes January 2011, Vol.60, 680-684. doi:https://doi.org/10.2337/db10-0185
An Interferon-Induced Helicase (IFIH1) Gene Polymorphism Associates With Different Rates of Progression From Autoimmunity to Type 1 Diabetes
Christiane Winkler; Claudia Lauber; Kerstin Adler; Harald Grallert; Thomas Illig; Anette-Gabriele Ziegler; Ezio Bonifacio
Diabetes January 2011, Vol.60, 685-690. doi:https://doi.org/10.2337/db10-1269