Issues

Topics: diabetes mellitus, type 1 , control groups , c-peptide

Diabetes January 2011, Vol.60, 361-363. doi:https://doi.org/10.2337/db10-1506

Perspectives in Diabetes

Historical Perspective: Beginnings of the β-Cell: Current Perspectives in β-Cell Development

Philip A. Seymour; Maike Sander

Extract

Topics: pancreas , signal transduction , mice , transcription factor

Diabetes January 2011, Vol.60, 364-376. doi:https://doi.org/10.2337/db10-1068

Commentaries

Glucagon as a Critical Factor in the Pathology of Diabetes

Dale S. Edgerton; Alan D. Cherrington

Abstracts

Topics: glucagon , insulin , glucose , mice , streptozocin

Diabetes January 2011, Vol.60, 377-380. doi:https://doi.org/10.2337/db10-1594

A Therapeutic Insight in β-Cell Imaging?

Martin Gotthardt

Abstracts

Topics: diagnostic imaging , transplantation

Diabetes January 2011, Vol.60, 381-382. doi:https://doi.org/10.2337/db10-1591

Metabolism

Effects of Acute Hyperglucagonemia on Hepatic and Intestinal Lipoprotein Production and Clearance in Healthy Humans

Changting Xiao; Mirjana Pavlic; Linda Szeto; Bruce W. Patterson; Gary F. Lewis

Abstracts

Topics: glucagon , intestines , lipoproteins , lipoproteins, vldl , pancreas

Diabetes January 2011, Vol.60, 383-390. doi:https://doi.org/10.2337/db10-0763

Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice

Young Lee; May-Yun Wang; Xiu Quan Du; Maureen J. Charron; Roger H. Unger

Abstracts

Topics: gcgr gene , glucagon , insulin , mice , streptozocin

Diabetes January 2011, Vol.60, 391-397. doi:https://doi.org/10.2337/db10-0426

Hepatic Glycogen Supercompensation Activates AMP-Activated Protein Kinase, Impairs Insulin Signaling, and Reduces Glycogen Deposition in the Liver

Jason J. Winnick; Zhibo An; Christopher J. Ramnanan; Marta Smith; Jose M. Irimia; Doss W. Neal; Mary Courtney Moore; Peter J. Roach; Alan D. Cherrington

Abstract

Topics: glucose , glycogen , insulin , lactates , liver

Diabetes January 2011, Vol.60, 398-407. doi:https://doi.org/10.2337/db10-0592

Normal Postprandial Nonesterified Fatty Acid Uptake in Muscles Despite Increased Circulating Fatty Acids in Type 2 Diabetes

Sébastien M. Labbé; Etienne Croteau; Thomas Grenier-Larouche; Frédérique Frisch; René Ouellet; Réjean Langlois; Brigitte Guérin; Eric E. Turcotte; André C. Carpentier

Abstract

Topics: diabetes mellitus, type 2 , insulin , nonesterified fatty acids , skeletal muscles , postprandial period

Diabetes January 2011, Vol.60, 408-415. doi:https://doi.org/10.2337/db10-0997

Diet-Induced Muscle Insulin Resistance Is Associated With Extracellular Matrix Remodeling and Interaction With Integrin α₂β₁ in Mice

Li Kang; Julio E. Ayala; Robert S. Lee-Young; Zhonghua Zhang; Freyja D. James; P. Darrell Neufer; Ambra Pozzi; Mary M. Zutter; David H. Wasserman

Abstract

Topics: collagen , diet , heart failure , insulin , insulin resistance

Diabetes January 2011, Vol.60, 416-426. doi:https://doi.org/10.2337/db10-1116

The Adipocyte-Expressed Forkhead Transcription Factor Foxc2 Regulates Metabolism Through Altered Mitochondrial Function

Martin E. Lidell; Erin L. Seifert; Rickard Westergren; Mikael Heglind; Adrienne Gowing; Valentina Sukonina; Zahra Arani; Paula Itkonen; Simonetta Wallin; Fredrik Westberg; Julia Fernandez-Rodriguez; Markku Laakso; Tommy Nilsson; Xiao-Rong Peng; Mary-Ellen Harper; Sven Enerbäck

Abstract

Topics: adipocytes , foxc2 gene , mitochondria , polymerase chain reaction , transcription factor

Diabetes January 2011, Vol.60, 427-435. doi:https://doi.org/10.2337/db10-0409

Participation of Hindbrain AMP-Activated Protein Kinase in Glucoprivic Feeding

Ai-Jun Li; Qing Wang; Sue Ritter

Abstract

Topics: ampk , hindbrain , porokeratosis, disseminated superficial actinic , rats , catecholamines

Diabetes January 2011, Vol.60, 436-442. doi:https://doi.org/10.2337/db10-0352

Effects of Insulin on Brain Glucose Metabolism in Impaired Glucose Tolerance

Jussi Hirvonen; Kirsi A. Virtanen; Lauri Nummenmaa; Jarna C. Hannukainen; Miikka-Juhani Honka; Marco Bucci; Sergey V. Nesterov; Riitta Parkkola; Juha Rinne; Patricia Iozzo; Pirjo Nuutila

Abstract

Topics: brain , glucose intolerance , glucose metabolism , insulin , positron-emission tomography

Diabetes January 2011, Vol.60, 443-447. doi:https://doi.org/10.2337/db10-0940

Distinct Roles of Endothelial and Adipocyte Caveolin-1 in Macrophage Infiltration and Adipose Tissue Metabolic Activity

Nolwenn Briand; Soazig Le Lay; William C. Sessa; Pascal Ferré; Isabelle Dugail

Abstract

Topics: adipocytes , adipose tissue , caveolins , endothelium , macrophages

Diabetes January 2011, Vol.60, 448-453. doi:https://doi.org/10.2337/db10-0856

Signal Transduction

Phosphatidylinositol-4-Phosphate-5-Kinase α Deficiency Alters Dynamics of Glucose-Stimulated Insulin Release to Improve Glucohomeostasis and Decrease Obesity in Mice

Ping Huang; Oladapo Yeku; Haihong Zong; Phyllis Tsang; Wenjuan Su; Xiao Yu; Shuzhi Teng; Mary Osisami; Yasunori Kanaho; Jeffrey E. Pessin; Michael A. Frohman

Abstracts

Topics: glucose , insulin , insulin secretion , mice , obesity

Diabetes January 2011, Vol.60, 454-463. doi:https://doi.org/10.2337/db10-0614

Obesity Studies

Smad3 Deficiency in Mice Protects Against Insulin Resistance and Obesity Induced by a High-Fat Diet

Chek Kun Tan; Nicolas Leuenberger; Ming Jie Tan; Yew Wai Yan; Yinghui Chen; Ravi Kambadur; Walter Wahli; Nguan Soon Tan

Abstract

Topics: adipocytes , mice , obesity , smad3 gene , insulin resistance

Diabetes January 2011, Vol.60, 464-476. doi:https://doi.org/10.2337/db10-0801

Effects of Metformin on Body Weight and Body Composition in Obese Insulin-Resistant Children: A Randomized Clinical Trial

Jack A. Yanovski; Jonathan Krakoff; Christine G. Salaita; Jennifer R. McDuffie; Merel Kozlosky; Nancy G. Sebring; James C. Reynolds; Sheila M. Brady; Karim A. Calis

Abstracts

Topics: child , insulin , insulin resistance , metformin , obesity

Diabetes January 2011, Vol.60, 477-485. doi:https://doi.org/10.2337/db10-1185

Selective Inactivation of c-Jun NH₂-Terminal Kinase in Adipose Tissue Protects Against Diet-Induced Obesity and Improves Insulin Sensitivity in Both Liver and Skeletal Muscle in Mice

Xinmei Zhang; Aimin Xu; Sookja K. Chung; Justin H.B. Cresser; Gary Sweeney; Rachel L.C. Wong; Anning Lin; Karen S.L. Lam

Abstract

Topics: adipose tissue , fatty-acid-binding protein, adipocyte , insulin , mice , mice, transgenic

Diabetes January 2011, Vol.60, 486-495. doi:https://doi.org/10.2337/db10-0650

A Newly Identified CG301269 Improves Lipid and Glucose Metabolism Without Body Weight Gain Through Activation of Peroxisome Proliferator–Activated Receptor α and γ

Hyun Woo Jeong; Joo-Won Lee; Woo Sik Kim; Sung Sik Choe; Kyung-Hee Kim; Ho Seon Park; Hyun Jung Shin; Gha Young Lee; Dongkyu Shin; Hanjae Lee; Jun Hee Lee; Eun Bok Choi; Hyeon Kyu Lee; Heekyoung Chung; Seung Bum Park; Kyong Soo Park; Hyo-Soo Kim; Seonggu Ro; Jae Bum Kim

Abstracts

Topics: agonists , lipids , mice , obesity , peroxisome proliferator-activated receptors

Diabetes January 2011, Vol.60, 496-506. doi:https://doi.org/10.2337/db09-1145

Hypoxia-Induced Intrauterine Growth Restriction Increases the Susceptibility of Rats to High-Fat Diet–Induced Metabolic Syndrome

Christian F. Rueda-Clausen; Vernon W. Dolinsky; Jude S. Morton; Spencer D. Proctor; Jason R.B. Dyck; Sandra T. Davidge

Abstracts

Topics: diet , fetal growth retardation , heart failure , insulin , rats

Diabetes January 2011, Vol.60, 507-516. doi:https://doi.org/10.2337/db10-1239

Hyperglycemia Activates Caspase-1 and TXNIP-Mediated IL-1β Transcription in Human Adipose Tissue

Tim B. Koenen; Rinke Stienstra; Lambertus J. van Tits; Jacqueline de Graaf; Anton F.H. Stalenhoef; Leo A.B. Joosten; Cees J. Tack; Mihai G. Netea

Abstracts

Topics: adipocytes , adipose tissue , caspase-1 , glucose , hyperglycemia

Diabetes January 2011, Vol.60, 517-524. doi:https://doi.org/10.2337/db10-0266

Islet Studies

Disruption of Hepatocyte Growth Factor/c-Met Signaling Enhances Pancreatic β-Cell Death and Accelerates the Onset of Diabetes

Jose Mellado-Gil; Taylor C. Rosa; Cem Demirci; Jose A. Gonzalez-Pertusa; Silvia Velazquez-Garcia; Sara Ernst; Shelley Valle; Rupangi C. Vasavada; Andrew F. Stewart; Laura C. Alonso; Adolfo Garcia-Ocaña

Abstract

Topics: cytokine , met gene , mice , pancreas , streptozocin

Diabetes January 2011, Vol.60, 525-536. doi:https://doi.org/10.2337/db09-1305

Interleukin-6 Enhances Glucose-Stimulated Insulin Secretion From Pancreatic β-Cells: Potential Involvement of the PLC-IP₃–Dependent Pathway

Toshinobu Suzuki; Junta Imai; Tetsuya Yamada; Yasushi Ishigaki; Keizo Kaneko; Kenji Uno; Yutaka Hasegawa; Hisamitsu Ishihara; Yoshitomo Oka; Hideki Katagiri

Abstracts

Topics: interleukin-6 , glucose , mice , insulin

Diabetes January 2011, Vol.60, 537-547. doi:https://doi.org/10.2337/db10-0796

The Expression and Function of Glucose-Dependent Insulinotropic Polypeptide in the Embryonic Mouse Pancreas

Krishna Prasadan; Masayuki Koizumi; Sidhartha Tulachan; Chiyo Shiota; Nikesh Lath; Jose Paredes; Ping Guo; Yousef El-Gohary; Marcus Malek; Sohail Shah; George K. Gittes

Abstract

Topics: embryo , insulin , pancreas , immunohistochemistry , reverse transcriptase polymerase chain reaction

Diabetes January 2011, Vol.60, 548-554. doi:https://doi.org/10.2337/db09-0035

Immunology and Transplantation

Induction of Mixed Chimerism With MHC-Mismatched but Not Matched Bone Marrow Transplants Results in Thymic Deletion of Host-Type Autoreactive T-Cells in NOD Mice

Jeremy Racine; Miao Wang; Chunyan Zhang; Chia-Lei Lin; Hongjun Liu; Ivan Todorov; Mark Atkinson; Defu Zeng

Abstract

Topics: chimera organism , chimerism , donors , host (organism) , mismatch

Diabetes January 2011, Vol.60, 555-564. doi:https://doi.org/10.2337/db10-0827

Combined Small Interfering RNA Therapy and In Vivo Magnetic Resonance Imaging in Islet Transplantation

Ping Wang; Mehmet V. Yigit; Zdravka Medarova; Lingling Wei; Guangping Dai; Christian Schuetz; Anna Moore

Abstracts

Topics: caspase-3 , islets of langerhans transplantation , magnetic resonance imaging , rna, small interfering , tissue transplants

Diabetes January 2011, Vol.60, 565-571. doi:https://doi.org/10.2337/db10-1400

Pathophysiology

Reduction in Basal Nitric Oxide Activity Causes Albuminuria

Christian Ott; Markus P. Schneider; Christian Delles; Markus P. Schlaich; Roland E. Schmieder

Abstracts

Topics: albumins , albuminuria , hypertension , infusion procedures , nitric oxide

Diabetes January 2011, Vol.60, 572-576. doi:https://doi.org/10.2337/db09-1630

Thirty Years of Prospective Nationwide Incidence of Childhood Type 1 Diabetes: The Accelerating Increase by Time Tends to Level Off in Sweden

Yonas Berhan; Ingeborg Waernbaum; Torbjörn Lind; Anna Möllsten; Gisela Dahlquist; for the Swedish Childhood Diabetes Study Group*

Abstracts

Topics: age of onset , child , diabetes mellitus, type 1

Diabetes January 2011, Vol.60, 577-581. doi:https://doi.org/10.2337/db10-0813

Complications

Levels of Oxidized LDL and Advanced Glycation End Products–Modified LDL in Circulating Immune Complexes Are Strongly Associated With Increased Levels of Carotid Intima-Media Thickness and Its Progression in Type 1 Diabetes

Maria F. Lopes-Virella; Kelly J. Hunt; Nathaniel L. Baker; John Lachin; David M. Nathan; G. Virella; the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group

Abstracts

Topics: carotid intima-media thickness , low-density lipoproteins , edic trial , diabetes mellitus, type 1 , dcct trial

Diabetes January 2011, Vol.60, 582-589. doi:https://doi.org/10.2337/db10-0915

The Protective Role of Smad7 in Diabetic Kidney Disease: Mechanism and Therapeutic Potential

Hai Yong Chen; Xiao R. Huang; Wansheng Wang; Jin Hua Li; Rainer L. Heuchel; Arthur C.K. Chung; Hui Yao Lan

Abstract

Topics: diabetic nephropathy , fibrosis , inflammation , kidney , mice

Diabetes January 2011, Vol.60, 590-601. doi:https://doi.org/10.2337/db10-0403

Adrenergic Mediation of Hypoglycemia-Associated Autonomic Failure

Ranjani Ramanathan; Philip E. Cryer

Abstracts

Topics: cholinergic agents , hypoglycemia , phentolamine , propranolol , saline solutions

Diabetes January 2011, Vol.60, 602-606. doi:https://doi.org/10.2337/db10-1374

Progression of Carotid Artery Intima-Media Thickness During 12 Years in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study

Joseph F. Polak; Jye-Yu C. Backlund; Patricia A. Cleary; Anita P. Harrington; Daniel H. O’Leary; John M. Lachin; David M. Nathan; for the DCCT/EDIC Research Group

Abstracts

Topics: carotid intima-media thickness , dcct trial , edic trial

Diabetes January 2011, Vol.60, 607-613. doi:https://doi.org/10.2337/db10-0296

Increased Expression and Activity of 12-Lipoxygenase in Oxygen-Induced Ischemic Retinopathy and Proliferative Diabetic Retinopathy: Implications in Retinal Neovascularization

Mohamed Al-Shabrawey; Rene Mussell; Khalid Kahook; Amany Tawfik; Mohamed Eladl; Vijay Sarthy; Julian Nussbaum; Ahmed El-Marakby; Sun Young Park; Zafer Gurel; Nader Sheibani; Krishna Rao Maddipati

Abstract

Topics: 12-hydroxy-5,8,10,14-eicosatetraenoic acid , hydroxyeicosatetraenoic acids , ischemia , mice , retinal diseases

Diabetes January 2011, Vol.60, 614-624. doi:https://doi.org/10.2337/db10-0008

Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress–Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo

Yi Tan; Tomonaga Ichikawa; Jinqing Li; Qiusheng Si; Huaitao Yang; Xiangbai Chen; Curtis S. Goldblatt; Colin J. Meyer; Xiaokun Li; Lu Cai; Taixing Cui

Abstracts

Topics: cardiac myocytes , glucose uptake , heart , insulin , insulin resistance

Diabetes January 2011, Vol.60, 625-633. doi:https://doi.org/10.2337/db10-1164

Resveratrol Improves Oxidative Stress and Protects Against Diabetic Nephropathy Through Normalization of Mn-SOD Dysfunction in AMPK/SIRT1-Independent Pathway

Munehiro Kitada; Shinji Kume; Noriko Imaizumi; Daisuke Koya

Abstract

Topics: ampk , kidney , mice , mitochondria , dna, mitochondrial

Diabetes January 2011, Vol.60, 634-643. doi:https://doi.org/10.2337/db10-0386

Pharmacology and Therapeutics

Selective Reversible Inhibition of Liver Carnitine Palmitoyl-Transferase 1 by Teglicar Reduces Gluconeogenesis and Improves Glucose Homeostasis

Roberto Conti; Edoardo Mannucci; Pompeo Pessotto; Emanuela Tassoni; Paolo Carminati; Fabio Giannessi; Arduino Arduini

Abstracts

Topics: glucose , insulin , liver , mice , mice, inbred c57bl

Diabetes January 2011, Vol.60, 644-651. doi:https://doi.org/10.2337/db10-0346

Adiponectin Pretreatment Counteracts the Detrimental Effect of a Diabetic Environment on Endothelial Progenitors

Simon F. Leicht; Theresa M. Schwarz; Patrick C. Hermann; Jochen Seissler; Alexandra Aicher; Christopher Heeschen

Abstracts

Topics: adiponectin , animal model , cell count , endothelium , hindlimb

Diabetes January 2011, Vol.60, 652-661. doi:https://doi.org/10.2337/db10-0240

Genetics

Resequencing and Analysis of Variation in the TCF7L2 Gene in African Americans Suggests That SNP rs7903146 Is the Causal Diabetes Susceptibility Variant

Nicholette D. Palmer; Jessica M. Hester; S. Sandy An; Adebowale Adeyemo; Charles Rotimi; Carl D. Langefeld; Barry I. Freedman; Maggie C.Y. Ng; Donald W. Bowden

Abstract

Topics: diabetes mellitus, type 2 , genome , imputation , single nucleotide polymorphism , tcf7l2 gene

Diabetes January 2011, Vol.60, 662-668. doi:https://doi.org/10.2337/db10-0134

Links Between Insulin Resistance, Adenosine A_2B Receptors, and Inflammatory Markers in Mice and Humans

Robert A. Figler; Guoquan Wang; Susseela Srinivasan; Dae Young Jung; Zhiyou Zhang; James S. Pankow; Katya Ravid; Bertil Fredholm; Catherine C. Hedrick; Stephen S. Rich; Jason K. Kim; Kathryn F. LaNoue; Joel Linden

Abstracts

Topics: adenosine , adenosine receptors , adenosine-5'-(n-ethylcarboxamide) , electroconvulsive therapy , inflammatory markers

Diabetes January 2011, Vol.60, 669-679. doi:https://doi.org/10.2337/db10-1070

The Same Chromosome 9p21.3 Locus Is Associated With Type 2 Diabetes and Coronary Artery Disease in a Chinese Han Population

Abstracts

Topics: 9p21 nucleotide sequence , coronary arteriosclerosis , diabetes mellitus, type 2 , single nucleotide polymorphism

Diabetes January 2011, Vol.60, 680-684. doi:https://doi.org/10.2337/db10-0185

An Interferon-Induced Helicase (IFIH1) Gene Polymorphism Associates With Different Rates of Progression From Autoimmunity to Type 1 Diabetes

Christiane Winkler; Claudia Lauber; Kerstin Adler; Harald Grallert; Thomas Illig; Anette-Gabriele Ziegler; Ezio Bonifacio

Abstracts

Topics: autoantibodies , autoimmunity , child , diabetes mellitus, type 1 , follow-up

Diabetes January 2011, Vol.60, 685-690. doi:https://doi.org/10.2337/db10-1269

Erratum

Errata

Extract

Topics: adipocytes , body mass index procedure , cyclic amp , diamond , forskolin

Diabetes January 2011, Vol.60, 691. doi:https://doi.org/10.2337/db11-er02

Issues and Events

Topics: country of turkey , cupressus , diabetes mellitus, type 2 , florida , glycemic control

Diabetes January 2011, Vol.60, 692. doi:https://doi.org/10.2337/db11-ie02

Online Letters to the Editor

Comment on: Soranzo et al. Common Variants at 10 Genomic Loci Influence Hemoglobin A_1C Levels via Glycemic and Nonglycemic Pathways. Diabetes 2010;59:3229–3239

Rosa Corcoy

Extract

Topics: genome , hemoglobin a , hemoglobin a, glycosylated

Diabetes January 2011, Vol.60, e10. doi:https://doi.org/10.2337/db10-1368

Response to Comment on: Soranzo et al. Common Variants at 10 Genomic Loci Influence Hemoglobin A_1C Levels via Glycemic and Nonglycemic Pathways. Diabetes 2010;59:3229–3239

James B. Meigs; Nicole Soranzo; the rest of the MAGIC HbA1c GWAS co-authors

Extract

Topics: genome , hemoglobin a

Diabetes January 2011, Vol.60, e11. doi:https://doi.org/10.2337/db10-1692

Response to Comment on: Meagher et al. Neutralization of Interleukin-16 Protects Nonobese Diabetic Mice From Autoimmune Type 1 Diabetes by a CCL4-Dependent Mechanism. Diabetes 2010;59:2862–2871

Craig Meagher; William Cruikshank; Terry L. Delovitch

Extract

Topics: autoimmunity , carbon tetrachloride , diabetes mellitus, type 1 , interleukin-16 , mice, inbred nod

Diabetes January 2011, Vol.60, e13. doi:https://doi.org/10.2337/db10-1620

Online Letters To The Editor

Comment on: Meagher et al. Neutralization of Interleukin-16 Protects Nonobese Diabetic Mice From Autoimmune Type 1 Diabetes by a CCL4-Dependent Mechanism. Diabetes 2010;59:2862–2871

Francesco Vendrame; Francesco Dotta

Extract