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Issues
Editorial
Persistence is the Twin Sister of Excellence: An Important Lesson for Attempts to Prevent and Reverse Type 1 Diabetes
Diabetes February 2011, Vol.60, 693-694. doi:https://doi.org/10.2337/db10-1810
Commentaries
Learning From Glycosuria
Diabetes February 2011, Vol.60, 695-696. doi:https://doi.org/10.2337/db10-1667
Metabolism
Diabetes in Mice With Selective Impairment of Insulin Action in Glut4-Expressing Tissues
Hua V. Lin; Hongxia Ren; Varman T. Samuel; Hui-Young Lee; Taylor Y. Lu; Gerald I. Shulman; Domenico Accili
Diabetes February 2011, Vol.60, 700-709. doi:https://doi.org/10.2337/db10-1056
Thyroid Transcription Factor‐1 Regulates Feeding Behavior via Melanocortin Pathway in the Hypothalamus
Jae Geun Kim; Byong Seo Park; Chang Ho Yun; Hyun Jun Kim; Sang Soo Kang; Angela Valentina D’Elia; Giuseppe Damante; Ki-Up Lee; Jeong Woo Park; Eun Sook Kim; Il Seong Namgoong; Young Il Kim; Byung Ju Lee
Diabetes February 2011, Vol.60, 710-719. doi:https://doi.org/10.2337/db10-0183
Identification of Metabolic Modifiers That Underlie Phenotypic Variations in Energy-Balance Regulation
Diabetes February 2011, Vol.60, 726-734. doi:https://doi.org/10.2337/db10-1331
Deletion of Lkb1 in Pro-Opiomelanocortin Neurons Impairs Peripheral Glucose Homeostasis in Mice
Marc Claret; Mark A. Smith; Claude Knauf; Hind Al-Qassab; Angela Woods; Amanda Heslegrave; Kaisa Piipari; Julian J. Emmanuel; André Colom; Philippe Valet; Patrice D. Cani; Ghazala Begum; Anne White; Phillip Mucket; Marco Peters; Keiko Mizuno; Rachel L. Batterham; K. Peter Giese; Alan Ashworth; Remy Burcelin; Michael L. Ashford; David Carling; Dominic J. Withers
Diabetes February 2011, Vol.60, 735-745. doi:https://doi.org/10.2337/db10-1055
Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways
Fei Xiao; Zhiying Huang; Houkai Li; Junjie Yu; Chunxia Wang; Shanghai Chen; Qingshu Meng; Ying Cheng; Xiang Gao; Jia Li; Yong Liu; Feifan Guo
Diabetes February 2011, Vol.60, 746-756. doi:https://doi.org/10.2337/db10-1246
Polymerase I and Transcript Release Factor Regulates Lipolysis via a Phosphorylation-Dependent Mechanism
Diabetes February 2011, Vol.60, 757-765. doi:https://doi.org/10.2337/db10-0744
Molecular Mechanism by Which AMP-Activated Protein Kinase Activation Promotes Glycogen Accumulation in Muscle
Diabetes February 2011, Vol.60, 766-774. doi:https://doi.org/10.2337/db10-1148
Inflammatory Induction of Human Resistin Causes Insulin Resistance in Endotoxemic Mice
Diabetes February 2011, Vol.60, 775-783. doi:https://doi.org/10.2337/db10-1416
Obesity Studies
Physical Exercise Reduces Circulating Lipopolysaccharide and TLR4 Activation and Improves Insulin Signaling in Tissues of DIO Rats
Alexandre G. Oliveira; Bruno M. Carvalho; Natália Tobar; Eduardo R. Ropelle; José R. Pauli; Renata A. Bagarolli; Dioze Guadagnini; José B.C. Carvalheira; Mario J.A. Saad
Diabetes February 2011, Vol.60, 784-796. doi:https://doi.org/10.2337/db09-1907
Differential Lipid Partitioning Between Adipocytes and Tissue Macrophages Modulates Macrophage Lipotoxicity and M2/M1 Polarization in Obese Mice
Xavier Prieur; Crystal Y.L. Mok; Vidya R. Velagapudi; Vanessa Núñez; Lucía Fuentes; David Montaner; Ko Ishikawa; Alberto Camacho; Nuria Barbarroja; Stephen O’Rahilly; Jaswinder K. Sethi; Joaquin Dopazo; Matej Orešič; Mercedes Ricote; Antonio Vidal-Puig
Diabetes February 2011, Vol.60, 797-809. doi:https://doi.org/10.2337/db10-0705
Diet and Gastrointestinal Bypass–Induced Weight Loss: The Roles of Ghrelin and Peptide YY
Keval Chandarana; Cigdem Gelegen; Efthimia Karra; Agharul I. Choudhury; Megan E. Drew; Veronique Fauveau; Benoit Viollet; Fabrizio Andreelli; Dominic J. Withers; Rachel L. Batterham
Diabetes February 2011, Vol.60, 810-818. doi:https://doi.org/10.2337/db10-0566
Increased Expression of Macrophage-Inducible C-type Lectin in Adipose Tissue of Obese Mice and Humans
Masayuki Ichioka; Takayoshi Suganami; Naoto Tsuda; Ibuki Shirakawa; Yoichiro Hirata; Noriko Satoh-Asahara; Yuri Shimoda; Miyako Tanaka; Misa Kim-Saijo; Yoshihiro Miyamoto; Yasutomi Kamei; Masataka Sata; Yoshihiro Ogawa
Diabetes February 2011, Vol.60, 819-826. doi:https://doi.org/10.2337/db10-0864
Islet Studies
Rictor/mTORC2 Is Essential for Maintaining a Balance Between β-Cell Proliferation and Cell Size
Diabetes February 2011, Vol.60, 827-837. doi:https://doi.org/10.2337/db10-1194
SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans
Xiao-Qing Dai; Greg Plummer; Marina Casimir; Youhou Kang; Catherine Hajmrle; Herbert Y. Gaisano; Jocelyn E. Manning Fox; Patrick E. MacDonald
Diabetes February 2011, Vol.60, 838-847. doi:https://doi.org/10.2337/db10-0440
Ongoing β-Cell Turnover in Adult Nonhuman Primates Is Not Adaptively Increased in Streptozotocin-Induced Diabetes
Yoshifumi Saisho; Erica Manesso; Alexandra E. Butler; Ryan Galasso; Kylie Kavanagh; Mickey Flynn; Li Zhang; Paige Clark; Tatyana Gurlo; Gianna M. Toffolo; Claudio Cobelli; Janice D. Wagner; Peter C. Butler
Diabetes February 2011, Vol.60, 848-856. doi:https://doi.org/10.2337/db09-1368
Immunology and Transplantation
Natural Killer Cells From Children With Type 1 Diabetes Have Defects in NKG2D-Dependent Function and Signaling
Huilian Qin; I-Fang Lee; Constadina Panagiotopoulos; Xiaoxia Wang; Alvina D. Chu; Paul J. Utz; John J. Priatel; Rusung Tan
Diabetes February 2011, Vol.60, 857-866. doi:https://doi.org/10.2337/db09-1706
Interleukin-21 Is Critically Required in Autoimmune and Allogeneic Responses to Islet Tissue in Murine Models
Helen M. McGuire; Stacey Walters; Alexis Vogelzang; Carol M.Y. Lee; Kylie E. Webster; Jonathan Sprent; Daniel Christ; Shane Grey; Cecile King
Diabetes February 2011, Vol.60, 867-875. doi:https://doi.org/10.2337/db10-1157
Glucose and Inflammation Control Islet Vascular Density and β-Cell Function in NOD Mice: Control of Islet Vasculature and Vascular Endothelial Growth Factor by Glucose
Eitan M. Akirav; Maria-Teresa Baquero; Lynn W. Opare-Addo; Michael Akirav; Eva Galvan; Jake A. Kushner; David L. Rimm; Kevan C. Herold
Diabetes February 2011, Vol.60, 876-883. doi:https://doi.org/10.2337/db10-0793
RIG-I– and MDA5-Initiated Innate Immunity Linked With Adaptive Immunity Accelerates β-Cell Death in Fulminant Type 1 Diabetes
Kaoru Aida; Yoriko Nishida; Shoichiro Tanaka; Taro Maruyama; Akira Shimada; Takuya Awata; Masako Suzuki; Hiroki Shimura; Soichi Takizawa; Masashi Ichijo; Daiichiro Akiyama; Fumihiko Furuya; Akio Kawaguchi; Masahiro Kaneshige; Jun Itakura; Hideki Fujii; Toyoshi Endo; Tetsuro Kobayashi
Diabetes February 2011, Vol.60, 884-889. doi:https://doi.org/10.2337/db10-0795
Pathophysiology
SGLT2 Deletion Improves Glucose Homeostasis and Preserves Pancreatic β-Cell Function
Michael J. Jurczak; Hui-Young Lee; Andreas L. Birkenfeld; Francois R. Jornayvaz; David W. Frederick; Rebecca L. Pongratz; Xiaoxian Zhao; Gilbert W. Moeckel; Varman T. Samuel; Jean M. Whaley; Gerald I. Shulman; Richard G. Kibbey
Diabetes February 2011, Vol.60, 890-898. doi:https://doi.org/10.2337/db10-1328
Chronic Methylglyoxal Infusion by Minipump Causes Pancreatic β-Cell Dysfunction and Induces Type 2 Diabetes in Sprague-Dawley Rats
Diabetes February 2011, Vol.60, 899-908. doi:https://doi.org/10.2337/db10-0627
Glycosylation Failure Extends to Glycoproteins in Gestational Diabetes Mellitus: Evidence From Reduced α2-6 Sialylation and Impaired Immunomodulatory Activities of Pregnancy-Related Glycodelin-A
Cheuk-Lun Lee; Philip C.N. Chiu; Poh-Choo Pang; Ivan K. Chu; Kai-Fai Lee; Riitta Koistinen; Hannu Koistinen; Markku Seppälä; Howard R. Morris; Bérangère Tissot; Maria Panico; Anne Dell; William S.B. Yeung
Diabetes February 2011, Vol.60, 909-917. doi:https://doi.org/10.2337/db10-1186
Genetic Defects in Human Pericentrin Are Associated With Severe Insulin Resistance and Diabetes
Isabel Huang-Doran; Louise S. Bicknell; Francis M. Finucane; Nuno Rocha; Keith M. Porter; Y.C. Loraine Tung; Ferenc Szekeres; Anna Krook; John J. Nolan; Mark O’Driscoll; Michael Bober; Stephen O’Rahilly; Andrew P. Jackson; Robert K. Semple; for the Majewski Osteodysplastic Primordial Dwarfism Study Group
Diabetes February 2011, Vol.60, 925-935. doi:https://doi.org/10.2337/db10-1334
Differential Expression of Novel Adiponectin Receptor-1 Transcripts in Skeletal Muscle of Subjects With Normal Glucose Tolerance and Type 2 Diabetes
Reut Ashwal; Rina Hemi; Amir Tirosh; Reut Gordin; Eleanor Yissachar; Anat Cohen-Dayag; Avi Rosenberg; Avraham Karasik; Matthias Blüher; Hannah Kanety
Diabetes February 2011, Vol.60, 936-946. doi:https://doi.org/10.2337/db09-0532
Complications
Carbonylation Contributes to SERCA2a Activity Loss and Diastolic Dysfunction in a Rat Model of Type 1 Diabetes
Chun Hong Shao; Haley L. Capek; Kaushik P. Patel; Mu Wang; Kang Tang; Cyrus DeSouza; Ryoji Nagai; William Mayhan; Muthu Periasamy; Keshore R. Bidasee
Diabetes February 2011, Vol.60, 947-959. doi:https://doi.org/10.2337/db10-1145
Activation of Peroxisome Proliferator–Activated Receptor δ Inhibits Streptozotocin-Induced Diabetic Nephropathy Through Anti-Inflammatory Mechanisms in Mice
Yuichi Matsushita; Daisuke Ogawa; Jun Wada; Noriko Yamamoto; Kenichi Shikata; Chikage Sato; Hiromi Tachibana; Noriko Toyota; Hirofumi Makino
Diabetes February 2011, Vol.60, 960-968. doi:https://doi.org/10.2337/db10-1361
Intracavernous Delivery of a Designed Angiopoietin-1 Variant Rescues Erectile Function by Enhancing Endothelial Regeneration in the Streptozotocin-Induced Diabetic Mouse
Hai-Rong Jin; Woo Jean Kim; Jae Sook Song; Shuguang Piao; Min Ji Choi; Munkhbayar Tumurbaatar; Sun Hwa Shin; Guo Nan Yin; Gou Young Koh; Ji-Kan Ryu; Jun-Kyu Suh
Diabetes February 2011, Vol.60, 969-980. doi:https://doi.org/10.2337/db10-0354
Tubular Injury in a Rat Model of Type 2 Diabetes Is Prevented by Metformin: A Possible Role of HIF-1α Expression and Oxygen Metabolism
Yumi Takiyama; Tatsuo Harumi; Jun Watanabe; Yukihiro Fujita; Jun Honjo; Norihiko Shimizu; Yuichi Makino; Masakazu Haneda
Diabetes February 2011, Vol.60, 981-992. doi:https://doi.org/10.2337/db10-0655
Serum Vascular Adhesion Protein-1 Predicts 10-Year Cardiovascular and Cancer Mortality in Individuals With Type 2 Diabetes
Hung-Yuan Li; Yi-Der Jiang; Tien-Jyun Chang; Jung-Nan Wei; Mao-Shin Lin; Cheng-Hsin Lin; Fu-Tien Chiang; Shyang-Rong Shih; Chi Sheng Hung; Cyue-Huei Hua; David J. Smith; Jani Vanio; Lee-Ming Chuang
Diabetes February 2011, Vol.60, 993-999. doi:https://doi.org/10.2337/db10-0607
Genetics
The ENPP1 Q121 Variant Predicts Major Cardiovascular Events in High-Risk Individuals: Evidence for Interaction With Obesity in Diabetic Patients
Simonetta Bacci; Stefano Rizza; Sabrina Prudente; Belinda Spoto; Christine Powers; Antonio Facciorusso; Antonio Pacilli; Davide Lauro; Alessandra Testa; Yuan-Yuan Zhang; Giuseppe Di Stolfo; Francesca Mallamaci; Giovanni Tripepi; Rui Xu; Davide Mangiacotti; Filippo Aucella; Renato Lauro; Ernest V. Gervino; Thomas H. Hauser; Massimiliano Copetti; Salvatore De Cosmo; Fabio Pellegrini; Carmine Zoccali; Massimo Federici; Alessandro Doria; Vincenzo Trischitta
Diabetes February 2011, Vol.60, 1000-1007. doi:https://doi.org/10.2337/db10-1300
Mendelian Randomization Studies Do Not Support a Role for Raised Circulating Triglyceride Levels Influencing Type 2 Diabetes, Glucose Levels, or Insulin Resistance
N. Maneka G. De Silva; Rachel M. Freathy; Tom M. Palmer; Louise A. Donnelly; Jian'an Luan; Tom Gaunt; Claudia Langenberg; Michael N. Weedon; Beverley Shields; Beatrice A. Knight; Kirsten J. Ward; Manjinder S. Sandhu; Roger M. Harbord; Mark I. McCarthy; George Davey Smith; Shah Ebrahim; Andrew T. Hattersley; Nicholas Wareham; Debbie A. Lawlor; Andrew D. Morris; Colin N.A. Palmer; Timothy M. Frayling
Diabetes February 2011, Vol.60, 1008-1018. doi:https://doi.org/10.2337/db10-1317
Global Gene Expression Profiles of Subcutaneous Adipose and Muscle From Glucose-Tolerant, Insulin-Sensitive, and Insulin-Resistant Individuals Matched for BMI
Steven C. Elbein; Philip A. Kern; Neda Rasouli; Aiwei Yao-Borengasser; Neeraj K. Sharma; Swapan K. Das
Diabetes February 2011, Vol.60, 1019-1029. doi:https://doi.org/10.2337/db10-1270
Tests for Genetic Interactions in Type 1 Diabetes: Linkage and Stratification Analyses of 4,422 Affected Sib-Pairs
Grant Morahan; Munish Mehta; Ian James; Wei-Min Chen; Beena Akolkar; Henry A. Erlich; Joan E. Hilner; Cécile Julier; Jørn Nerup; Concepcion Nierras; Flemming Pociot; John A. Todd; Stephen S. Rich; for the Type 1 Diabetes Genetics Consortium
Diabetes February 2011, Vol.60, 1030-1040. doi:https://doi.org/10.2337/db10-1195
An Allele of IKZF1 (Ikaros) Conferring Susceptibility to Childhood Acute Lymphoblastic Leukemia Protects Against Type 1 Diabetes
Austin D.-E. Swafford; Joanna M.M. Howson; Lucy J. Davison; Chris Wallace; Deborah J. Smyth; Helen Schuilenburg; Meeta Maisuria-Armer; Trupti Mistry; Michael J. Lenardo; John A. Todd
Diabetes February 2011, Vol.60, 1041-1044. doi:https://doi.org/10.2337/db10-0446
Stepwise or Linear Decrease in Penetrance of Type 1 Diabetes With Lower-Risk HLA Genotypes Over the Past 40 Years
Andrea K. Steck; Taylor K. Armstrong; Sunanda R. Babu; George S. Eisenbarth; the Type 1 Diabetes Genetics Consortium
Diabetes February 2011, Vol.60, 1045-1049. doi:https://doi.org/10.2337/db10-1419
