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Volume 60, Issue 4
1 April 2011
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ISSN 0012-1797
EISSN 1939-327X
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Metabolism

Central Endocannabinoid Signaling Regulates Hepatic Glucose Production and Systemic Lipolysis
James D. O’Hare; Elizabeth Zieliński; Bob Cheng; Thomas Scherer; Christoph Buettner
View articletitled, Central Endocannabinoid Signaling Regulates Hepatic Glucose Production and Systemic Lipolysis
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Diabetes March 2011, Vol.60, 1055-1062. doi:https://doi.org/10.2337/db10-0962
Neuronal Receptor Activity–Modifying Protein 1 Promotes Energy Expenditure in Mice
Zhongming Zhang; Xuebo Liu; Donald A. Morgan; Adisa Kuburas; Daniel R. Thedens; Andrew F. Russo; Kamal Rahmouni
View articletitled, Neuronal Receptor Activity–Modifying Protein 1 Promotes Energy Expenditure in Mice
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Diabetes March 2011, Vol.60, 1063-1071. doi:https://doi.org/10.2337/db10-0692
Endoplasmic Reticulum Stress Promotes LIPIN2-Dependent Hepatic Insulin Resistance
Dongryeol Ryu; Woo-Young Seo; Young-Sil Yoon; Yo-Na Kim; Su Sung Kim; Hye-Jin Kim; Tae-Sik Park; Cheol Soo Choi; Seung-Hoi Koo
View articletitled, Endoplasmic Reticulum Stress Promotes LIPIN2-Dependent Hepatic Insulin Resistance
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Diabetes March 2011, Vol.60, 1072-1081. doi:https://doi.org/10.2337/db10-1046
Disruption of Thyroid Hormone Activation in Type 2 Deiodinase Knockout Mice Causes Obesity With Glucose Intolerance and Liver Steatosis Only at Thermoneutrality
Melany Castillo; Jessica A. Hall; Mayrin Correa-Medina; Cintia Ueta; Hye Won Kang; David E. Cohen; Antonio C. Bianco
View articletitled, Disruption of Thyroid Hormone Activation in Type 2 Deiodinase Knockout Mice Causes Obesity With Glucose Intolerance and Liver Steatosis Only at Thermoneutrality
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Diabetes March 2011, Vol.60, 1082-1089. doi:https://doi.org/10.2337/db10-0758
High Pancreatic n-3 Fatty Acids Prevent STZ-Induced Diabetes in Fat-1 Mice: Inflammatory Pathway Inhibition
Jérôme Bellenger; Sandrine Bellenger; Amandine Bataille; Karen A. Massey; Anna Nicolaou; Mickaël Rialland; Christian Tessier; Jing X. Kang; Michel Narce
View articletitled, High Pancreatic n-3 Fatty Acids Prevent STZ-Induced Diabetes in Fat-1 Mice: Inflammatory Pathway Inhibition
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Diabetes March 2011, Vol.60, 1090-1099. doi:https://doi.org/10.2337/db10-0901
Hematopoietic Cell–Restricted Deletion of CD36 Reduces High-Fat Diet–Induced Macrophage Infiltration and Improves Insulin Signaling in Adipose Tissue
Hayley T. Nicholls; Greg Kowalski; David J. Kennedy; Steve Risis; Lee A. Zaffino; Nadine Watson; Peter Kanellakis; Matthew J. Watt; Alex Bobik; Arend Bonen; Maria Febbraio; Graeme I. Lancaster; Mark A. Febbraio
View articletitled, Hematopoietic Cell–Restricted Deletion of CD36 Reduces High-Fat Diet–Induced Macrophage Infiltration and Improves Insulin Signaling in Adipose Tissue
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Diabetes March 2011, Vol.60, 1100-1110. doi:https://doi.org/10.2337/db10-1353

Signal Transduction

Bimodal Effect on Pancreatic β-Cells of Secretory Products From Normal or Insulin-Resistant Human Skeletal Muscle
Karim Bouzakri; Peter Plomgaard; Thierry Berney; Marc Y. Donath; Bente Karlund Pedersen; Philippe A. Halban
View articletitled, Bimodal Effect on Pancreatic β-Cells of Secretory Products From Normal or Insulin-Resistant Human Skeletal Muscle
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Diabetes March 2011, Vol.60, 1111-1121. doi:https://doi.org/10.2337/db10-1178
Retinal Microglial Activation and Inflammation Induced by Amadori-Glycated Albumin in a Rat Model of Diabetes
Ahmed S. Ibrahim; Azza B. El-Remessy; Suraporn Matragoon; Wenbo Zhang; Yogin Patel; Sohail Khan; Mohammed M. Al-Gayyar; Mamdouh M. El-Shishtawy; Gregory I. Liou
View articletitled, Retinal Microglial Activation and Inflammation Induced by Amadori-Glycated Albumin in a Rat Model of Diabetes
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Diabetes March 2011, Vol.60, 1122-1133. doi:https://doi.org/10.2337/db10-1160
p38 Mitogen-Activated Protein Kinase-Dependent Transactivation of ErbB Receptor Family: A Novel Common Mechanism for Stress-Induced IRS-1 Serine Phosphorylation and Insulin Resistance
Rina Hemi; Yafit Yochananov; Ehud Barhod; Michal Kasher-Meron; Avraham Karasik; Amir Tirosh; Hannah Kanety
View articletitled, p38 Mitogen-Activated Protein Kinase-Dependent Transactivation of ErbB Receptor Family<span class="subtitle-colon">: </span><span class="subtitle">A Novel Common Mechanism for Stress-Induced IRS-1 Serine Phosphorylation and Insulin Resistance</span>
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Diabetes March 2011, Vol.60, 1134-1145. doi:https://doi.org/10.2337/db09-1323
Focal Adhesion Remodeling Is Crucial for Glucose-Stimulated Insulin Secretion and Involves Activation of Focal Adhesion Kinase and Paxillin
Dieter Rondas; Alejandra Tomas; Philippe A. Halban
View articletitled, Focal Adhesion Remodeling Is Crucial for Glucose-Stimulated Insulin Secretion and Involves Activation of Focal Adhesion Kinase and Paxillin
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Diabetes March 2011, Vol.60, 1146-1157. doi:https://doi.org/10.2337/db10-0946

Obesity Studies

Novel Fat Depot–Specific Mechanisms Underlie Resistance to Visceral Obesity and Inflammation in 11β-Hydroxysteroid Dehydrogenase Type 1–Deficient Mice
Malgorzata Wamil; Jenny H. Battle; Sophie Turban; Tiina Kipari; David Seguret; Ricardo de Sousa Peixoto; Yvonne B. Nelson; Dominika Nowakowska; David Ferenbach; Lynne Ramage; Karen E. Chapman; Jeremy Hughes; Donald R. Dunbar; Jonathan R. Seckl; Nicholas M. Morton
View articletitled, Novel Fat Depot–Specific Mechanisms Underlie Resistance to Visceral Obesity and Inflammation in 11β-Hydroxysteroid Dehydrogenase Type 1–Deficient Mice
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Diabetes March 2011, Vol.60, 1158-1167. doi:https://doi.org/10.2337/db10-0830
Tumor Progression Locus 2 (TPL2) Regulates Obesity-Associated Inflammation and Insulin Resistance
James W. Perfield, II; Yunkyoung Lee; Gerald I. Shulman; Varman T. Samuel; Michael J. Jurczak; Eugene Chang; Chen Xie; Phillip N. Tsichlis; Martin S. Obin; Andrew S. Greenberg
View articletitled, Tumor Progression Locus 2 (TPL2) Regulates Obesity-Associated Inflammation and Insulin Resistance
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Diabetes March 2011, Vol.60, 1168-1176. doi:https://doi.org/10.2337/db10-0715
The Central Sirtuin 1/p53 Pathway Is Essential for the Orexigenic Action of Ghrelin
Douglas A. Velásquez; Gloria Martínez; Amparo Romero; María J. Vázquez; Katia D. Boit; Iria G. Dopeso-Reyes; Miguel López; Anxo Vidal; Ruben Nogueiras; Carlos Diéguez
View articletitled, The Central Sirtuin 1/p53 Pathway Is Essential for the Orexigenic Action of Ghrelin
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Diabetes March 2011, Vol.60, 1177-1185. doi:https://doi.org/10.2337/db10-0802

Islet Studies

Cyclin-Dependent Kinase 5 Promotes Pancreatic β-Cell Survival via Fak-Akt Signaling Pathways
Marie Daval; Tatyana Gurlo; Safia Costes; Chang-jiang Huang; Peter C. Butler
View articletitled, Cyclin-Dependent Kinase 5 Promotes Pancreatic β-Cell Survival via Fak-Akt Signaling Pathways
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Diabetes March 2011, Vol.60, 1186-1197. doi:https://doi.org/10.2337/db10-1048
Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic β-Cells
Wook Kim; Máire E. Doyle; Zhuo Liu; Qizong Lao; Yu-Kyong Shin; Olga D. Carlson; Hee Seung Kim; Sam Thomas; Joshua K. Napora; Eun Kyung Lee; Ruin Moaddel; Yan Wang; Stuart Maudsley; Bronwen Martin; Rohit N. Kulkarni; Josephine M. Egan
View articletitled, Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic β-Cells
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Diabetes March 2011, Vol.60, 1198-1209. doi:https://doi.org/10.2337/db10-1550
Δ40 Isoform of p53 Controls β-Cell Proliferation and Glucose Homeostasis in Mice
Charlotte Hinault; Dan Kawamori; Chong Wee Liew; Bernhard Maier; Jiang Hu; Susanna R. Keller; Raghavendra G. Mirmira; Heidi Scrable; Rohit N. Kulkarni
View articletitled, Δ40 Isoform of p53 Controls β-Cell Proliferation and Glucose Homeostasis in Mice
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Diabetes March 2011, Vol.60, 1210-1222. doi:https://doi.org/10.2337/db09-1379
In Vitro Recovery of ATP-Sensitive Potassium Channels in β-Cells From Patients With Congenital Hyperinsulinism of Infancy
Philippa D. Powell; Christine Bellanné-Chantelot; Sarah E. Flanagan; Sian Ellard; Raoul Rooman; Khalid Hussain; Mars Skae; Peter Clayton; Pascale de Lonlay; Mark J. Dunne; Karen E. Cosgrove
View articletitled, In Vitro Recovery of ATP-Sensitive Potassium Channels in β-Cells From Patients With Congenital Hyperinsulinism of Infancy
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Diabetes March 2011, Vol.60, 1223-1228. doi:https://doi.org/10.2337/db10-1443

Immunology and Transplantation

Prevention of “Humanized” Diabetogenic CD8 T-Cell Responses in HLA-Transgenic NOD Mice by a Multipeptide Coupled-Cell Approach
Marijke Niens; Alexandra E. Grier; Michele Marron; Thomas W.H. Kay; Dale L. Greiner; David V. Serreze
View articletitled, Prevention of “Humanized” Diabetogenic CD8 T-Cell Responses in HLA-Transgenic NOD Mice by a Multipeptide Coupled-Cell Approach
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Diabetes March 2011, Vol.60, 1229-1236. doi:https://doi.org/10.2337/db10-1523
Evidence That Nasal Insulin Induces Immune Tolerance to Insulin in Adults With Autoimmune Diabetes
Spiros Fourlanos; Christine Perry; Shane A. Gellert; Emanuela Martinuzzi; Roberto Mallone; Jeanne Butler; Peter G. Colman; Leonard C. Harrison
View articletitled, Evidence That Nasal Insulin Induces Immune Tolerance to Insulin in Adults With Autoimmune Diabetes
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Diabetes March 2011, Vol.60, 1237-1245. doi:https://doi.org/10.2337/db10-1360

Pathophysiology

Diet-Induced Adipose Tissue Inflammation and Liver Steatosis Are Prevented by DPP-4 Inhibition in Diabetic Mice
Jun Shirakawa; Hideki Fujii; Kei Ohnuma; Koichiro Sato; Yuzuru Ito; Mitsuyo Kaji; Eri Sakamoto; Megumi Koganei; Hajime Sasaki; Yoji Nagashima; Kikuko Amo; Kazutaka Aoki; Chikao Morimoto; Eiji Takeda; Yasuo Terauchi
View articletitled, Diet-Induced Adipose Tissue Inflammation and Liver Steatosis Are Prevented by DPP-4 Inhibition in Diabetic Mice
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Diabetes March 2011, Vol.60, 1246-1257. doi:https://doi.org/10.2337/db10-1338
Hyperuricemia as a Mediator of the Proinflammatory Endocrine Imbalance in the Adipose Tissue in a Murine Model of the Metabolic Syndrome
William Baldwin; Steven McRae; George Marek; David Wymer; Varinderpal Pannu; Chris Baylis; Richard J. Johnson; Yuri Y. Sautin
View articletitled, Hyperuricemia as a Mediator of the Proinflammatory Endocrine Imbalance in the Adipose Tissue in a Murine Model of the Metabolic Syndrome
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Diabetes March 2011, Vol.60, 1258-1269. doi:https://doi.org/10.2337/db10-0916
GIP Does Not Potentiate the Antidiabetic Effects of GLP-1 in Hyperglycemic Patients With Type 2 Diabetes
Nikolaos Mentis; Irfan Vardarli; Lars D. Köthe; Jens J. Holst; Carolyn F. Deacon; Michael Theodorakis; Juris J. Meier; Michael A. Nauck
View articletitled, GIP Does Not Potentiate the Antidiabetic Effects of GLP-1 in Hyperglycemic Patients With Type 2 Diabetes
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Diabetes March 2011, Vol.60, 1270-1276. doi:https://doi.org/10.2337/db10-1332
Duration of Lactation and Maternal Adipokines at 3 Years Postpartum
Alison M. Stuebe; Christos Mantzoros; Ken Kleinman; Matthew W. Gillman; Sheryl Rifas-Shiman; Erica P. Gunderson; Janet Rich-Edwards
View articletitled, Duration of Lactation and Maternal Adipokines at 3 Years Postpartum
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Diabetes March 2011, Vol.60, 1277-1285. doi:https://doi.org/10.2337/db10-0637

Complications

Role of Inflammation and Insulin Resistance in Endothelial Progenitor Cell Dysfunction
Cyrus V. Desouza; Frederick G. Hamel; Keshore Bidasee; Kelly O’Connell
View articletitled, Role of Inflammation and Insulin Resistance in Endothelial Progenitor Cell Dysfunction
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Diabetes March 2011, Vol.60, 1286-1294. doi:https://doi.org/10.2337/db10-0875
Insulin Resistance Impairs Circulating Angiogenic Progenitor Cell Function and Delays Endothelial Regeneration
Matthew B. Kahn; Nadira Y. Yuldasheva; Richard M. Cubbon; Jessica Smith; Sheikh T. Rashid; Hema Viswambharan; Helen Imrie; Afroze Abbas; Adil Rajwani; Amir Aziz; Vivek Baliga; Piruthivi Sukumar; Matthew Gage; Mark T. Kearney; Stephen B. Wheatcroft
View articletitled, Insulin Resistance Impairs Circulating Angiogenic Progenitor Cell Function and Delays Endothelial Regeneration
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Diabetes March 2011, Vol.60, 1295-1303. doi:https://doi.org/10.2337/db10-1080
Epigenetic Changes in Mitochondrial Superoxide Dismutase in the Retina and the Development of Diabetic Retinopathy
Qing Zhong; Renu A. Kowluru
View articletitled, Epigenetic Changes in Mitochondrial Superoxide Dismutase in the Retina and the Development of Diabetic Retinopathy
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Diabetes March 2011, Vol.60, 1304-1313. doi:https://doi.org/10.2337/db10-0133
MicroRNA-200b Regulates Vascular Endothelial Growth Factor–Mediated Alterations in Diabetic Retinopathy
Kara McArthur; Biao Feng; Yuexiu Wu; Shali Chen; Subrata Chakrabarti
View articletitled, MicroRNA-200b Regulates Vascular Endothelial Growth Factor–Mediated Alterations in Diabetic Retinopathy
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Diabetes March 2011, Vol.60, 1314-1323. doi:https://doi.org/10.2337/db10-1557
Partial Inhibition of Insulin Secretion Results in Glucose Intolerance but Not Hyperglucagonemia
Ranjani P. Ramanathan; Ana María Arbeláez; Philip E. Cryer
View articletitled, Partial Inhibition of Insulin Secretion Results in Glucose Intolerance but Not Hyperglucagonemia
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Diabetes March 2011, Vol.60, 1324-1328. doi:https://doi.org/10.2337/db10-1586

Genetics

A Bivariate Genome-Wide Approach to Metabolic Syndrome: STAMPEED Consortium
Aldi T. Kraja; Dhananjay Vaidya; James S. Pankow; Mark O. Goodarzi; Themistocles L. Assimes; Iftikhar J. Kullo; Ulla Sovio; Rasika A. Mathias; Yan V. Sun; Nora Franceschini; Devin Absher; Guo Li; Qunyuan Zhang; Mary F. Feitosa; Nicole L. Glazer; Talin Haritunians; Anna-Liisa Hartikainen; Joshua W. Knowles; Kari E. North; Carlos Iribarren; Brian Kral; Lisa Yanek; Paul F. O’Reilly; Mark I. McCarthy; Cashell Jaquish; David J. Couper; Aravinda Chakravarti; Bruce M. Psaty; Lewis C. Becker; Michael A. Province; Eric Boerwinkle; Thomas Quertermous; Leena Palotie; Marjo-Riitta Jarvelin; Diane M. Becker; Sharon L.R. Kardia; Jerome I. Rotter; Yii-Der Ida Chen; Ingrid B. Borecki
View articletitled, A Bivariate Genome-Wide Approach to Metabolic Syndrome<span class="subtitle-colon">: </span><span class="subtitle">STAMPEED Consortium</span>
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Diabetes March 2011, Vol.60, 1329-1339. doi:https://doi.org/10.2337/db10-1011
Updated Genetic Score Based on 34 Confirmed Type 2 Diabetes Loci Is Associated With Diabetes Incidence and Regression to Normoglycemia in the Diabetes Prevention Program
Marie-France Hivert; Kathleen A. Jablonski; Leigh Perreault; Richa Saxena; Jarred B. McAteer; Paul W. Franks; Richard F. Hamman; Steven E. Kahn; Steven Haffner; the DIAGRAM Consortium; James B. Meigs; David Altshuler; William C. Knowler; Jose C. Florez; for the Diabetes Prevention Program Research Group
View articletitled, Updated Genetic Score Based on 34 Confirmed Type 2 Diabetes Loci Is Associated With Diabetes Incidence and Regression to Normoglycemia in the Diabetes Prevention Program
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Diabetes March 2011, Vol.60, 1340-1348. doi:https://doi.org/10.2337/db10-1119
Permanent Neonatal Diabetes and Enteric Anendocrinosis Associated With Biallelic Mutations in NEUROG3
Oscar Rubio-Cabezas; Jan N. Jensen; Maria I. Hodgson; Ethel Codner; Sian Ellard; Palle Serup; Andrew T. Hattersley
View articletitled, Permanent Neonatal Diabetes and Enteric Anendocrinosis Associated With Biallelic Mutations in <em>NEUROG3</em>
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Diabetes March 2011, Vol.60, 1349-1353. doi:https://doi.org/10.2337/db10-1008
Unmasking Genes in a Type 1 Diabetes–Resistant Mouse Strain That Enhances Pathogenic CD8 T-Cell Responses
John P. Driver; Yi-Guang Chen; Weidong Zhang; Seblewongel Asrat; David V. Serreze
View articletitled, Unmasking Genes in a Type 1 Diabetes–Resistant Mouse Strain That Enhances Pathogenic CD8 T-Cell Responses
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Diabetes March 2011, Vol.60, 1354-1359. doi:https://doi.org/10.2337/db10-0885

Issues and Events

Issues and Events
View articletitled, Issues and Events
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Diabetes March 2011, Vol.60, 1360. doi:https://doi.org/10.2337/db11-ie04

Online Letters to the Editor

Comment on: Kumar et al. Fat Cell–Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism. Diabetes 2010;59:1397–1406
Adnan Erol
View articletitled, Comment on: Kumar et al. Fat Cell–Specific Ablation of <em>Rictor</em> in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism. Diabetes 2010;59:1397–1406
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Diabetes March 2011, Vol.60, e14. doi:https://doi.org/10.2337/db10-1606
Response to Comment on: Kumar et al. Fat Cell–Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism. Diabetes 2010;59:1397–1406
Anil Kumar; Susanna R. Keller; Jason K. Kim; Mark A. Magnuson; Thurl E. Harris
View articletitled, Response to Comment on: Kumar et al. Fat Cell–Specific Ablation of <em>Rictor</em> in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism. Diabetes 2010;59:1397–1406
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Diabetes March 2011, Vol.60, e15. doi:https://doi.org/10.2337/db11-0135
Système International (SI) Units Table
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
300-OR: Beneficial Effect of the Combination Therapy of Cagrilintide, a Dual Amylin/Calcitonin Agonist, and Tirzepatide, a Dual GLP-1/GIP Agonist, on Body Weight Loss in Obese Rats
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
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