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Volume 60, Issue 5
1 May 2011
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ISSN 0012-1797
EISSN 1939-327X
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Perspectives in Diabetes

Magnetic Resonance Spectroscopy Studies of Human Metabolism
Douglas E. Befroy; Gerald I. Shulman
View articletitled, Magnetic Resonance Spectroscopy Studies of Human Metabolism
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Diabetes April 2011, Vol.60, 1361-1369. doi:https://doi.org/10.2337/db09-0916

PERSPECTIVES IN DIABETES

How Does Type 1 Diabetes Develop?: The Notion of Homicide or β-Cell Suicide Revisited
Mark A. Atkinson; Jeffrey A. Bluestone; George S. Eisenbarth; Matthias Hebrok; Kevan C. Herold; Domenico Accili; Massimo Pietropaolo; Peter R. Arvan; Matthias Von Herrath; Dorene S. Markel; Christopher J. Rhodes
View articletitled, How Does Type 1 Diabetes Develop?<span class="subtitle-colon">: </span><span class="subtitle">The Notion of Homicide or β-Cell Suicide Revisited</span>
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Diabetes April 2011, Vol.60, 1370-1379. doi:https://doi.org/10.2337/db10-1797

COMMENTARY

Fractalkine: A Cellular Link Between Adipose Tissue Inflammation and Vascular Pathologies
William T. Cefalu
View articletitled, Fractalkine: A Cellular Link Between Adipose Tissue Inflammation and Vascular Pathologies
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Diabetes April 2011, Vol.60, 1380-1382. doi:https://doi.org/10.2337/db11-0239

New Methodologies and Databases

Multimodality Imaging of β-Cells in Mouse Models of Type 1 and 2 Diabetes
Jing Yong; Julia Rasooly; Hoa Dang; Yuxin Lu; Blake Middleton; Zesong Zhang; Larry Hon; Mohammad Namavari; David B. Stout; Mark A. Atkinson; Jide Tian; Sanjiv Sam Gambhir; Daniel L. Kaufman
View articletitled, Multimodality Imaging of β-Cells in Mouse Models of Type 1 and 2 Diabetes
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Diabetes April 2011, Vol.60, 1383-1392. doi:https://doi.org/10.2337/db10-0907
Generation of Stable Pluripotent Stem Cells From NOD Mouse Tail-Tip Fibroblasts
Jun Liu; Michelle P. Ashton; Huseyin Sumer; Moira K. O’Bryan; Thomas C. Brodnicki; Paul J. Verma
View articletitled, Generation of Stable Pluripotent Stem Cells From NOD Mouse Tail-Tip Fibroblasts
Supplementary data
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Diabetes April 2011, Vol.60, 1393-1398. doi:https://doi.org/10.2337/db10-1540

Metabolism

O-GlcNAcylation Increases ChREBP Protein Content and Transcriptional Activity in the Liver
Céline Guinez; Gaëlle Filhoulaud; Fadila Rayah-Benhamed; Solenne Marmier; Céline Dubuquoy; Renaud Dentin; Marthe Moldes; Anne-Françoise Burnol; Xiaoyong Yang; Tony Lefebvre; Jean Girard; Catherine Postic
View articletitled, <em>O</em>-GlcNAcylation Increases ChREBP Protein Content and Transcriptional Activity in the Liver
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Diabetes April 2011, Vol.60, 1399-1413. doi:https://doi.org/10.2337/db10-0452
Leptin Therapy Reverses Hyperglycemia in Mice With Streptozotocin-Induced Diabetes, Independent of Hepatic Leptin Signaling
Heather C. Denroche; Jasna Levi; Rhonda D. Wideman; Roveena M. Sequeira; Frank K. Huynh; Scott D. Covey; Timothy J. Kieffer
View articletitled, Leptin Therapy Reverses Hyperglycemia in Mice With Streptozotocin-Induced Diabetes, Independent of Hepatic Leptin Signaling
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Diabetes April 2011, Vol.60, 1414-1423. doi:https://doi.org/10.2337/db10-0958
Central Leptin Signaling Is Required to Normalize Myocardial Fatty Acid Oxidation Rates in Caloric-Restricted ob/ob Mice
Crystal Sloan; Joseph Tuinei; Katherine Nemetz; Jonathan Frandsen; Jamie Soto; Noah Wride; Tomoki Sempokuya; Luis Alegria; Heiko Bugger; E. Dale Abel
View articletitled, Central Leptin Signaling Is Required to Normalize Myocardial Fatty Acid Oxidation Rates in Caloric-Restricted <em>ob/ob</em> Mice
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Diabetes April 2011, Vol.60, 1424-1434. doi:https://doi.org/10.2337/db10-1106
Fasting-Induced Protein Phosphatase 1 Regulatory Subunit Contributes to Postprandial Blood Glucose Homeostasis via Regulation of Hepatic Glycogenesis
Xiaolin Luo; Yongxian Zhang; Xiangbo Ruan; Xiaomeng Jiang; Lu Zhu; Xiao Wang; Qiurong Ding; Weizhong Liu; Yi Pan; Zhenzhen Wang; Yan Chen
View articletitled, Fasting-Induced Protein Phosphatase 1 Regulatory Subunit Contributes to Postprandial Blood Glucose Homeostasis via Regulation of Hepatic Glycogenesis
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Diabetes April 2011, Vol.60, 1435-1445. doi:https://doi.org/10.2337/db10-1663
Nobiletin Attenuates VLDL Overproduction, Dyslipidemia, and Atherosclerosis in Mice With Diet-Induced Insulin Resistance
Erin E. Mulvihill; Julia M. Assini; Justin K. Lee; Emma M. Allister; Brian G. Sutherland; Julie B. Koppes; Cynthia G. Sawyez; Jane Y. Edwards; Dawn E. Telford; Alexandre Charbonneau; Philippe St-Pierre; André Marette; Murray W. Huff
View articletitled, Nobiletin Attenuates VLDL Overproduction, Dyslipidemia, and Atherosclerosis in Mice With Diet-Induced Insulin Resistance
Supplementary data
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Diabetes April 2011, Vol.60, 1446-1457. doi:https://doi.org/10.2337/db10-0589
Pigment Epithelium–Derived Factor Regulates Lipid Metabolism via Adipose Triglyceride Lipase
Melissa L. Borg; Zane B. Andrews; Elia J. Duh; Rudolf Zechner; Peter J. Meikle; Matthew J. Watt
View articletitled, Pigment Epithelium–Derived Factor Regulates Lipid Metabolism via Adipose Triglyceride Lipase
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Diabetes April 2011, Vol.60, 1458-1466. doi:https://doi.org/10.2337/db10-0845
Effect of Acute Hypoglycemia on Human Cerebral Glucose Metabolism Measured by 13C Magnetic Resonance Spectroscopy
Kim C.C. van de Ven; Bastiaan E. de Galan; Marinette van der Graaf; Alexander A. Shestov; Pierre-Gilles Henry; Cees J.J. Tack; Arend Heerschap
View articletitled, Effect of Acute Hypoglycemia on Human Cerebral Glucose Metabolism Measured by <sup>13</sup>C Magnetic Resonance Spectroscopy
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Diabetes April 2011, Vol.60, 1467-1473. doi:https://doi.org/10.2337/db10-1592
Recombinant Human Leptin Treatment Does Not Improve Insulin Action in Obese Subjects With Type 2 Diabetes
Bettina Mittendorfer; Jeffrey F. Horowitz; Alex M. DePaoli; Mark A. McCamish; Bruce W. Patterson; Samuel Klein
View articletitled, Recombinant Human Leptin Treatment Does Not Improve Insulin Action in Obese Subjects With Type 2 Diabetes
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Diabetes April 2011, Vol.60, 1474-1477. doi:https://doi.org/10.2337/db10-1302
Improved Insulin Sensitivity by GLUT12 Overexpression in Mice
Scott H. Purcell; Lauren B. Aerni-Flessner; Alexandra R. Willcockson; Kelly A. Diggs-Andrews; Simon J. Fisher; Kelle H. Moley
View articletitled, Improved Insulin Sensitivity by GLUT12 Overexpression in Mice
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Diabetes April 2011, Vol.60, 1478-1482. doi:https://doi.org/10.2337/db11-0033

Signal Transduction

Ablation of PI3K p110-α Prevents High-Fat Diet–Induced Liver Steatosis
Mohar Chattopadhyay; Elzbieta S. Selinger; Lisa M. Ballou; Richard Z. Lin
View articletitled, Ablation of PI3K p110-α Prevents High-Fat Diet–Induced Liver Steatosis
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Diabetes April 2011, Vol.60, 1483-1492. doi:https://doi.org/10.2337/db10-0869
Metformin Inhibits Nuclear Receptor TR4–Mediated Hepatic Stearoyl-CoA Desaturase 1 Gene Expression With Altered Insulin Sensitivity
Eungseok Kim; Ning-Chun Liu; I-Chen Yu; Hung-Yun Lin; Yi-Fen Lee; Janet D. Sparks; Lu-Min Chen; Chawnshang Chang
View articletitled, Metformin Inhibits Nuclear Receptor TR4–Mediated Hepatic Stearoyl-CoA Desaturase 1 Gene Expression With Altered Insulin Sensitivity
Supplementary data
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Diabetes April 2011, Vol.60, 1493-1503. doi:https://doi.org/10.2337/db10-0393

Obesity Studies

Visceral Adipocyte Hypertrophy is Associated With Dyslipidemia Independent of Body Composition and Fat Distribution in Women
Alain Veilleux; Maude Caron-Jobin; Suzanne Noël; Philippe Y. Laberge; André Tchernof
View articletitled, Visceral Adipocyte Hypertrophy is Associated With Dyslipidemia Independent of Body Composition and Fat Distribution in Women
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Diabetes April 2011, Vol.60, 1504-1511. doi:https://doi.org/10.2337/db10-1039
Fractalkine Is a Novel Human Adipochemokine Associated With Type 2 Diabetes
Rachana Shah; Christine C. Hinkle; Jane F. Ferguson; Nehal N. Mehta; Mingyao Li; Liming Qu; Yun Lu; Mary E. Putt; Rexford S. Ahima; Muredach P. Reilly
View articletitled, Fractalkine Is a Novel Human Adipochemokine Associated With Type 2 Diabetes
Supplementary data
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Diabetes April 2011, Vol.60, 1512-1518. doi:https://doi.org/10.2337/db10-0956
Adiponectin Inhibits Lipolysis in Mouse Adipocytes
Liping Qiao; Brice Kinney; Jerome Schaack; Jianhua Shao
View articletitled, Adiponectin Inhibits Lipolysis in Mouse Adipocytes
Supplementary data
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Diabetes April 2011, Vol.60, 1519-1527. doi:https://doi.org/10.2337/db10-1017
Epigenetic Gene Promoter Methylation at Birth Is Associated With Child’s Later Adiposity
Keith M. Godfrey; Allan Sheppard; Peter D. Gluckman; Karen A. Lillycrop; Graham C. Burdge; Cameron McLean; Joanne Rodford; Joanne L. Slater-Jefferies; Emma Garratt; Sarah R. Crozier; B. Starling Emerald; Catharine R. Gale; Hazel M. Inskip; Cyrus Cooper; Mark A. Hanson
View articletitled, Epigenetic Gene Promoter Methylation at Birth Is Associated With Child’s Later Adiposity
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Diabetes April 2011, Vol.60, 1528-1534. doi:https://doi.org/10.2337/db10-0979

Islet Studies

Glucose- and Hormone-Induced cAMP Oscillations in α- and β-Cells Within Intact Pancreatic Islets
Geng Tian; Stellan Sandler; Erik Gylfe; Anders Tengholm
View articletitled, Glucose- and Hormone-Induced cAMP Oscillations in α- and β-Cells Within Intact Pancreatic Islets
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Diabetes April 2011, Vol.60, 1535-1543. doi:https://doi.org/10.2337/db10-1087

Pathophysiology

Activin A Levels Are Associated With Abnormal Glucose Regulation in Patients With Myocardial Infarction: Potential Counteracting Effects of Activin A on Inflammation
Geir Ø. Andersen; Thor Ueland; Eva C. Knudsen; Hanne Scholz; Arne Yndestad; Afaf Sahraoui; Camilla Smith; Tove Lekva; Kari Otterdal; Bente Halvorsen; Ingebjørg Seljeflot; Pål Aukrust
View articletitled, Activin A Levels Are Associated With Abnormal Glucose Regulation in Patients With Myocardial Infarction<span class="subtitle-colon">: </span><span class="subtitle">Potential Counteracting Effects of Activin A on Inflammation</span>
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Diabetes April 2011, Vol.60, 1544-1551. doi:https://doi.org/10.2337/db10-1493
Effects of Rosiglitazone, Glyburide, and Metformin on β-Cell Function and Insulin Sensitivity in ADOPT
Steven E. Kahn; John M. Lachin; Bernard Zinman; Steven M. Haffner; R. Paul Aftring; Gitanjali Paul; Barbara G. Kravitz; William H. Herman; Giancarlo Viberti; Rury R. Holman; and the ADOPT Study Group
View articletitled, Effects of Rosiglitazone, Glyburide, and Metformin on β-Cell Function and Insulin Sensitivity in ADOPT
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Diabetes April 2011, Vol.60, 1552-1560. doi:https://doi.org/10.2337/db10-1392
Rapid Tachyphylaxis of the Glucagon-Like Peptide 1–Induced Deceleration of Gastric Emptying in Humans
Michael A. Nauck; Guido Kemmeries; Jens J. Holst; Juris J. Meier
View articletitled, Rapid Tachyphylaxis of the Glucagon-Like Peptide 1–Induced Deceleration of Gastric Emptying in Humans
Supplementary data
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Diabetes April 2011, Vol.60, 1561-1565. doi:https://doi.org/10.2337/db10-0474
Genetic Ablation of cGMP-Dependent Protein Kinase Type I Causes Liver Inflammation and Fasting Hyperglycemia
Stefan Z. Lutz; Anita M. Hennige; Susanne Feil; Andreas Peter; Andrea Gerling; Jürgen Machann; Stefan M. Kröber; Michaela Rath; Annette Schürmann; Cora Weigert; Hans-Ulrich Häring; Robert Feil
View articletitled, Genetic Ablation of cGMP-Dependent Protein Kinase Type I Causes Liver Inflammation and Fasting Hyperglycemia
Supplementary data
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Diabetes April 2011, Vol.60, 1566-1576. doi:https://doi.org/10.2337/db10-0760
Rhythmic Diurnal Gene Expression in Human Adipose Tissue From Individuals Who Are Lean, Overweight, and Type 2 Diabetic
Daniella T. Otway; Simone Mäntele; Silvia Bretschneider; John Wright; Paul Trayhurn; Debra J. Skene; M. Denise Robertson; Jonathan D. Johnston
View articletitled, Rhythmic Diurnal Gene Expression in Human Adipose Tissue From Individuals Who Are Lean, Overweight, and Type 2 Diabetic
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Diabetes April 2011, Vol.60, 1577-1581. doi:https://doi.org/10.2337/db10-1098

Complications

Increased GABAergic Output in the Ventromedial Hypothalamus Contributes to Impaired Hypoglycemic Counterregulation in Diabetic Rats
Owen Chan; Sachin Paranjape; Daniel Czyzyk; Adam Horblitt; Wanling Zhu; Yuyan Ding; Xiaoning Fan; Margretta Seashore; Robert Sherwin
View articletitled, Increased GABAergic Output in the Ventromedial Hypothalamus Contributes to Impaired Hypoglycemic Counterregulation in Diabetic Rats
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Diabetes April 2011, Vol.60, 1582-1589. doi:https://doi.org/10.2337/db10-1579
Plasma Kallikrein Mediates Retinal Vascular Dysfunction and Induces Retinal Thickening in Diabetic Rats
Allen Clermont; Tamie J. Chilcote; Takeshi Kita; Jia Liu; Priscilla Riva; Sukanto Sinha; Edward P. Feener
View articletitled, Plasma Kallikrein Mediates Retinal Vascular Dysfunction and Induces Retinal Thickening in Diabetic Rats
Supplementary data
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Diabetes April 2011, Vol.60, 1590-1598. doi:https://doi.org/10.2337/db10-1260

Pharmacology and Therapeutics

Antidiabetic Actions of Endogenous and Exogenous GLP-1 in Type 1 Diabetic Patients With and Without Residual β-Cell Function
Urd Kielgast; Jens J. Holst; Sten Madsbad
View articletitled, Antidiabetic Actions of Endogenous and Exogenous GLP-1 in Type 1 Diabetic Patients With and Without Residual β-Cell Function
Supplementary data
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Diabetes April 2011, Vol.60, 1599-1607. doi:https://doi.org/10.2337/db10-1790

Genetics

Effects of 34 Risk Loci for Type 2 Diabetes or Hyperglycemia on Lipoprotein Subclasses and Their Composition in 6,580 Nondiabetic Finnish Men
Alena Stančáková; Jussi Paananen; Pasi Soininen; Antti J. Kangas; Lori L. Bonnycastle; Mario A. Morken; Francis S. Collins; Anne U. Jackson; Michael L. Boehnke; Johanna Kuusisto; Mika Ala-Korpela; Markku Laakso
View articletitled, Effects of 34 Risk Loci for Type 2 Diabetes or Hyperglycemia on Lipoprotein Subclasses and Their Composition in 6,580 Nondiabetic Finnish Men
Supplementary data
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Diabetes April 2011, Vol.60, 1608-1616. doi:https://doi.org/10.2337/db10-1655
Associations of Common Genetic Variants With Age-Related Changes in Fasting and Postload Glucose: Evidence From 18 Years of Follow-Up of the Whitehall II Cohort
Anders C. Jensen; Adam Barker; Meena Kumari; Eric J. Brunner; Mika Kivimäki; Aroon D. Hingorani; Nicholas J. Wareham; Adam G. Tabák; Daniel R. Witte; Claudia Langenberg
View articletitled, Associations of Common Genetic Variants With Age-Related Changes in Fasting and Postload Glucose<span class="subtitle-colon">: </span><span class="subtitle">Evidence From 18 Years of Follow-Up of the Whitehall II Cohort</span>
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Diabetes April 2011, Vol.60, 1617-1623. doi:https://doi.org/10.2337/db10-1393
Inherited Variation in Vitamin D Genes Is Associated With Predisposition to Autoimmune Disease Type 1 Diabetes
Jason D. Cooper; Deborah J. Smyth; Neil M. Walker; Helen Stevens; Oliver S. Burren; Chris Wallace; Christopher Greissl; Elizabeth Ramos-Lopez; Elina Hyppönen; David B. Dunger; Timothy D. Spector; Willem H. Ouwehand; Thomas J. Wang; Klaus Badenhoop; John A. Todd
View articletitled, Inherited Variation in Vitamin D Genes Is Associated With Predisposition to Autoimmune Disease Type 1 Diabetes
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Diabetes April 2011, Vol.60, 1624-1631. doi:https://doi.org/10.2337/db10-1656
Drosophila Insulin Pathway Mutants Affect Visual Physiology and Brain Function Besides Growth, Lipid, and Carbohydrate Metabolism
Juan M. Murillo-Maldonado; Gustavo Sánchez-Chávez; Luis M. Salgado; Rocío Salceda; Juan R. Riesgo-Escovar
View articletitled, <em>Drosophila</em> Insulin Pathway Mutants Affect Visual Physiology and Brain Function Besides Growth, Lipid, and Carbohydrate Metabolism
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Diabetes April 2011, Vol.60, 1632-1636. doi:https://doi.org/10.2337/db10-1288
FTO, Type 2 Diabetes, and Weight Gain Throughout Adult Life: A Meta-Analysis of 41,504 Subjects From the Scandinavian HUNT, MDC, and MPP Studies
Jens K. Hertel; Stefan Johansson; Emily Sonestedt; Anna Jonsson; Rolv T. Lie; Carl G.P. Platou; Peter M. Nilsson; Gull Rukh; Kristian Midthjell; Kristian Hveem; Olle Melander; Leif Groop; Valeriya Lyssenko; Anders Molven; Marju Orho-Melander; Pål R. Njølstad
View articletitled, <em>FTO</em>, Type 2 Diabetes, and Weight Gain Throughout Adult Life<span class="subtitle-colon">: </span><span class="subtitle">A Meta-Analysis of 41,504 Subjects From the Scandinavian HUNT, MDC, and MPP Studies</span>
Supplementary data
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Diabetes April 2011, Vol.60, 1637-1644. doi:https://doi.org/10.2337/db10-1340

Erratum

Erratum
View articletitled, Erratum
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Diabetes April 2011, Vol.60, 1645. doi:https://doi.org/10.2337/db11-er05

Issues and Events

Issues and Events
View articletitled, Issues and Events
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Diabetes April 2011, Vol.60, 1646. doi:https://doi.org/10.2337/db11-ie05

Withdrawn

Withdrawn
View articletitled, Withdrawn
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Diabetes April 2011, Vol.60, e16. doi:https://doi.org/10.2337/db10-1605
MRI Metrics of Cerebral Endothelial Cell–Derived Exosomes for the Treatment of Cognitive Dysfunction Induced in Aging Rats Subjected to Type 2 Diabetes
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
300-OR: Beneficial Effect of the Combination Therapy of Cagrilintide, a Dual Amylin/Calcitonin Agonist, and Tirzepatide, a Dual GLP-1/GIP Agonist, on Body Weight Loss in Obese Rats
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