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Volume 60, Issue 6
1 June 2011
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ISSN 0012-1797
EISSN 1939-327X
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Perspectives in Diabetes

Efficacy of Metreleptin in Obese Patients With Type 2 Diabetes: Cellular and Molecular Pathways Underlying Leptin Tolerance
Hyun-Seuk Moon; Giuseppe Matarese; Aoife M. Brennan; John P. Chamberland; Xiaowen Liu; Christina G. Fiorenza; Geetha H. Mylvaganam; Luisa Abanni; Fortunata Carbone; Catherine J. Williams; Alex M. De Paoli; Benjamin E. Schneider; Christos S. Mantzoros
View articletitled, Efficacy of Metreleptin in Obese Patients With Type 2 Diabetes: Cellular and Molecular Pathways Underlying Leptin Tolerance
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Diabetes May 2011, Vol.60, 1647-1656. doi:https://doi.org/10.2337/db10-1791

Commentary

Stimulating IL-13 Receptors on T cells: A New Pathway for Tolerance Induction in Diabetes?­
F. Susan Wong
View articletitled, Stimulating IL-13 Receptors on T cells: A New Pathway for Tolerance Induction in Diabetes?­
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Diabetes May 2011, Vol.60, 1657-1659. doi:https://doi.org/10.2337/db11-0353

Metabolism

Liver Enzymes Are Associated With Hepatic Insulin Resistance, Insulin Secretion, and Glucagon Concentration in Healthy Men and Women
Fabrice Bonnet; Pierre-Henri Ducluzeau; Amalia Gastaldelli; Martine Laville; Christian H. Anderwald; Thomas Konrad; Andrea Mari; Beverley Balkau; for the RISC Study Group
View articletitled, Liver Enzymes Are Associated With Hepatic Insulin Resistance, Insulin Secretion, and Glucagon Concentration in Healthy Men and Women
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Diabetes May 2011, Vol.60, 1660-1667. doi:https://doi.org/10.2337/db10-1806

Signal Transduction

Cross-Talk Between Interferon-γ and Hedgehog Signaling Regulates Adipogenesis
Jelena Todoric; Birgit Strobl; Alexander Jais; Nicole Boucheron; Martina Bayer; Sabine Amann; Josefine Lindroos; Raffaele Teperino; Gerhard Prager; Martin Bilban; Wilfried Ellmeier; Franz Krempler; Mathias Müller; Oswald Wagner; Wolfgang Patsch; J. Andrew Pospisilik; Harald Esterbauer
View articletitled, Cross-Talk Between Interferon-γ and Hedgehog Signaling Regulates Adipogenesis
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Diabetes May 2011, Vol.60, 1668-1676. doi:https://doi.org/10.2337/db10-1628
Insulin Restores Gestational Diabetes Mellitus–Reduced Adenosine Transport Involving Differential Expression of Insulin Receptor Isoforms in Human Umbilical Vein Endothelium
Francisco Westermeier; Carlos Salomón; Marcelo González; Carlos Puebla; Enrique Guzmán-Gutiérrez; Fredi Cifuentes; Andrea Leiva; Paola Casanello; Luis Sobrevia
View articletitled, Insulin Restores Gestational Diabetes Mellitus–Reduced Adenosine Transport Involving Differential Expression of Insulin Receptor Isoforms in Human Umbilical Vein Endothelium
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Diabetes May 2011, Vol.60, 1677-1687. doi:https://doi.org/10.2337/db11-0155

Obesity Studies

Lack of Interleukin-1 Receptor I (IL-1RI) Protects Mice From High-Fat Diet–Induced Adipose Tissue Inflammation Coincident With Improved Glucose Homeostasis
Fiona C. McGillicuddy; Karen A. Harford; Clare M. Reynolds; Elizabeth Oliver; Mandy Claessens; Kingston H.G. Mills; Helen M. Roche
View articletitled, Lack of Interleukin-1 Receptor I (IL-1RI) Protects Mice From High-Fat Diet–Induced Adipose Tissue Inflammation Coincident With Improved Glucose Homeostasis
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Diabetes May 2011, Vol.60, 1688-1698. doi:https://doi.org/10.2337/db10-1278
Partial Reversibility of Hypothalamic Dysfunction and Changes in Brain Activity After Body Mass Reduction in Obese Subjects
Simone van de Sande-Lee; Fabrício R.S. Pereira; Dennys E. Cintra; Paula T. Fernandes; Adilson R. Cardoso; Célia R. Garlipp; Eliton A. Chaim; Jose C. Pareja; Bruno Geloneze; Li Min Li; Fernando Cendes; Licio A. Velloso
View articletitled, Partial Reversibility of Hypothalamic Dysfunction and Changes in Brain Activity After Body Mass Reduction in Obese Subjects
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Diabetes May 2011, Vol.60, 1699-1704. doi:https://doi.org/10.2337/db10-1614

Islet Studies

In Vivo Conditional Pax4 Overexpression in Mature Islet β-Cells Prevents Stress-Induced Hyperglycemia in Mice
Kai Hui Hu He; Petra I. Lorenzo; Thierry Brun; Carmen M. Jimenez Moreno; Deborah Aeberhard; Jorge Vallejo Ortega; Marion Cornu; Fabrizio Thorel; Asllan Gjinovci; Bernard Thorens; Pedro L. Herrera; Paolo Meda; Claes B. Wollheim; Benoit R. Gauthier
View articletitled, In Vivo Conditional Pax4 Overexpression in Mature Islet β-Cells Prevents Stress-Induced Hyperglycemia in Mice
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Diabetes May 2011, Vol.60, 1705-1715. doi:https://doi.org/10.2337/db10-1102

Immunology and Transplantation

IL-13Rα1 Expression on β-Cell–Specific T Cells in NOD Mice
Sarah S. Rasche; Michele Phillips; Marcia F. McInerney; Eli E. Sercarz; Anthony Quinn
View articletitled, IL-13Rα1 Expression on β-Cell–Specific T Cells in NOD Mice
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Diabetes May 2011, Vol.60, 1716-1725. doi:https://doi.org/10.2337/db10-1229
HLA-A2–Matched Peripheral Blood Mononuclear Cells From Type 1 Diabetic Patients, but Not Nondiabetic Donors, Transfer Insulitis to NOD-scid/γcnull/HLA-A2 Transgenic Mice Concurrent With the Expansion of Islet-Specific CD8+ T cells
Fatima Whitfield-Larry; Ellen F. Young; Garrick Talmage; Elizabeth Fudge; Anita Azam; Shipra Patel; Joseph Largay; Warren Byrd; John Buse; Ali S. Calikoglu; Leonard D. Shultz; Jeffrey A. Frelinger
View articletitled, HLA-A2–Matched Peripheral Blood Mononuclear Cells From Type 1 Diabetic Patients, but Not Nondiabetic Donors, Transfer Insulitis to NOD-<em>scid</em>/γc<sup>null</sup>/HLA-A2 Transgenic Mice Concurrent With the Expansion of Islet-Specific CD8<sup>+</sup> T cells
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Diabetes May 2011, Vol.60, 1726-1733. doi:https://doi.org/10.2337/db10-1287

Pathophysiology

Altered Skeletal Muscle Lipase Expression and Activity Contribute to Insulin Resistance in Humans
Pierre-Marie Badin; Katie Louche; Aline Mairal; Gerhard Liebisch; Gerd Schmitz; Arild C. Rustan; Steven R. Smith; Dominique Langin; Cedric Moro
View articletitled, Altered Skeletal Muscle Lipase Expression and Activity Contribute to Insulin Resistance in Humans
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Diabetes May 2011, Vol.60, 1734-1742. doi:https://doi.org/10.2337/db10-1364
Diabetic Visceral Hypersensitivity Is Associated With Activation of Mitogen-Activated Kinase in Rat Dorsal Root Ganglia
Gintautas Grabauskas; Andrea Heldsinger; Xiaoyin Wu; Dabo Xu; ShiYi Zhou; Chung Owyang
View articletitled, Diabetic Visceral Hypersensitivity Is Associated With Activation of Mitogen-Activated Kinase in Rat Dorsal Root Ganglia
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Diabetes May 2011, Vol.60, 1743-1751. doi:https://doi.org/10.2337/db10-1507
Postprandial and Fasting Hepatic Glucose Fluxes in Long-Standing Type 1 Diabetes
Michaela Kacerovsky; John Jones; Albrecht I. Schmid; Cristina Barosa; Angelika Lettner; Gertrud Kacerovsky-Bielesz; Julia Szendroedi; Marek Chmelik; Peter Nowotny; Visvanathan Chandramouli; Michael Wolzt; Michael Roden
View articletitled, Postprandial and Fasting Hepatic Glucose Fluxes in Long-Standing Type 1 Diabetes
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Diabetes May 2011, Vol.60, 1752-1758. doi:https://doi.org/10.2337/db10-1001

Complications

Diabetes Adversely Affects Macrophages During Atherosclerotic Plaque Regression in Mice
Saj Parathath; Lisa Grauer; Li-Shin Huang; Marie Sanson; Emilie Distel; Ira J. Goldberg; Edward A. Fisher
View articletitled, Diabetes Adversely Affects Macrophages During Atherosclerotic Plaque Regression in Mice
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Diabetes May 2011, Vol.60, 1759-1769. doi:https://doi.org/10.2337/db10-0778
Improvement of Cardiac Functions by Chronic Metformin Treatment Is Associated With Enhanced Cardiac Autophagy in Diabetic OVE26 Mice
Zhonglin Xie; Kai Lau; Bonnie Eby; Pedro Lozano; Chaoyong He; Becky Pennington; Hongliang Li; Shradha Rathi; Yunzhou Dong; Rong Tian; David Kem; Ming-Hui Zou
View articletitled, Improvement of Cardiac Functions by Chronic Metformin Treatment Is Associated With Enhanced Cardiac Autophagy in Diabetic OVE26 Mice
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Diabetes May 2011, Vol.60, 1770-1778. doi:https://doi.org/10.2337/db10-0351
Dedifferentiation of Immortalized Human Podocytes in Response to Transforming Growth Factor-β: A Model for Diabetic Podocytopathy
Michal Herman-Edelstein; Merlin C. Thomas; Vicki Thallas-Bonke; Moin Saleem; Mark E. Cooper; Phillip Kantharidis
View articletitled, Dedifferentiation of Immortalized Human Podocytes in Response to Transforming Growth Factor-β<span class="subtitle-colon">: </span><span class="subtitle">A Model for Diabetic Podocytopathy</span>
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Diabetes May 2011, Vol.60, 1779-1788. doi:https://doi.org/10.2337/db10-1110
Decreased Cerebrovascular Brain-Derived Neurotrophic Factor–Mediated Neuroprotection in the Diabetic Brain
Deepti Navaratna; Shu-zhen Guo; Kazhuhide Hayakawa; Xiaoying Wang; Chiara Gerhardinger; Eng H. Lo
View articletitled, Decreased Cerebrovascular Brain-Derived Neurotrophic Factor–Mediated Neuroprotection in the Diabetic Brain
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Diabetes May 2011, Vol.60, 1789-1796. doi:https://doi.org/10.2337/db10-1371

Genetics

Diazoxide-Unresponsive Congenital Hyperinsulinism in Children With Dominant Mutations of the β-Cell Sulfonylurea Receptor SUR1
Courtney M. MacMullen; Qing Zhou; Kara E. Snider; Paul H. Tewson; Susan A. Becker; Ali Rahim Aziz; Arupa Ganguly; Show-Ling Shyng; Charles A. Stanley
View articletitled, Diazoxide-Unresponsive Congenital Hyperinsulinism in Children With Dominant Mutations of the β-Cell Sulfonylurea Receptor SUR1
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Diabetes May 2011, Vol.60, 1797-1804. doi:https://doi.org/10.2337/db10-1631
Association of Genetic Loci With Glucose Levels in Childhood and Adolescence: A Meta-Analysis of Over 6,000 Children
Adam Barker; Stephen J. Sharp; Nicholas J. Timpson; Nabila Bouatia-Naji; Nicole M. Warrington; Stavroula Kanoni; Lawrence J. Beilin; Soren Brage; Panos Deloukas; David M. Evans; Anders Grontved; Neelam Hassanali; Deborah A. Lawlor; Cecile Lecoeur; Ruth J.F. Loos; Stephen J. Lye; Mark I. McCarthy; Trevor A. Mori; Ndeye Coumba Ndiaye; John P. Newnham; Ioanna Ntalla; Craig E. Pennell; Beate St Pourcain; Inga Prokopenko; Susan M. Ring; Naveed Sattar; Sophie Visvikis-Siest; George V. Dedoussis; Lyle J. Palmer; Philippe Froguel; George Davey Smith; Ulf Ekelund; Nicholas J. Wareham; Claudia Langenberg
View articletitled, Association of Genetic Loci With Glucose Levels in Childhood and Adolescence<span class="subtitle-colon">: </span><span class="subtitle">A Meta-Analysis of Over 6,000 Children</span>
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Diabetes May 2011, Vol.60, 1805-1812. doi:https://doi.org/10.2337/db10-1575
Mutations of the Same Conserved Glutamate Residue in NBD2 of the Sulfonylurea Receptor 1 Subunit of the KATP Channel Can Result in Either Hyperinsulinism or Neonatal Diabetes
Roope Männikkö; Sarah E. Flanagan; Xiuli Sim; David Segal; Khalid Hussain; Sian Ellard; Andrew T. Hattersley; Frances M. Ashcroft
View articletitled, Mutations of the Same Conserved Glutamate Residue in NBD2 of the Sulfonylurea Receptor 1 Subunit of the K<sub>ATP</sub> Channel Can Result in Either Hyperinsulinism or Neonatal Diabetes
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Diabetes May 2011, Vol.60, 1813-1822. doi:https://doi.org/10.2337/db10-1583

Erratum

Erratum
View articletitled, Erratum
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Diabetes May 2011, Vol.60, 1823. doi:https://doi.org/10.2337/db11-er06

Issues and Events

Issues and Events
View articletitled, Issues and Events
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Diabetes May 2011, Vol.60, 1824. doi:https://doi.org/10.2337/db11-ie06

Online Letters to the Editor

Comment on: Atkinson. It's Time to Consider Changing the Rules: The Rationale for Rethinking Control Groups in Clinical Trials Aimed at Reversing Type 1 Diabetes. Diabetes 2011;60:361–363
Srinath Sanda; Carla J. Greenbaum
View articletitled, Comment on: Atkinson. It's Time to Consider Changing the Rules: The Rationale for Rethinking Control Groups in Clinical Trials Aimed at Reversing Type 1 Diabetes. Diabetes 2011;60:361–363
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Diabetes May 2011, Vol.60, e17. doi:https://doi.org/10.2337/db11-0253
Response to Comment on: Atkinson. It's Time to Consider Changing the Rules: The Rationale for Rethinking Control Groups in Clinical Trials Aimed at Reversing Type 1 Diabetes. Diabetes 2011;60:361–363
Mark A. Atkinson
View articletitled, Response to Comment on: Atkinson. It's Time to Consider Changing the Rules: The Rationale for Rethinking Control Groups in Clinical Trials Aimed at Reversing Type 1 Diabetes. Diabetes 2011;60:361–363
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Diabetes May 2011, Vol.60, e18. doi:https://doi.org/10.2337/db11-0365
Système International (SI) Units Table
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
300-OR: Beneficial Effect of the Combination Therapy of Cagrilintide, a Dual Amylin/Calcitonin Agonist, and Tirzepatide, a Dual GLP-1/GIP Agonist, on Body Weight Loss in Obese Rats
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
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