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Volume 60, Issue 7
1 July 2011
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ISSN 0012-1797
EISSN 1939-327X
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Perspectives in Diabetes

MicroRNAs in β-Cell Biology, Insulin Resistance, Diabetes and Its Complications
Selene L. Fernandez-Valverde; Ryan J. Taft; John S. Mattick
View articletitled, MicroRNAs in β-Cell Biology, Insulin Resistance, Diabetes and Its Complications
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Diabetes June 2011, Vol.60, 1825-1831. doi:https://doi.org/10.2337/db11-0171
Diabetes Complications: The MicroRNA Perspective
Phillip Kantharidis; Bo Wang; Rosemarie M. Carew; Hui Yao Lan
View articletitled, Diabetes Complications: The MicroRNA Perspective
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Diabetes June 2011, Vol.60, 1832-1837. doi:https://doi.org/10.2337/db11-0082
The Paradox of Progress: Environmental Disruption of Metabolism and the Diabetes Epidemic
Brian A. Neel; Robert M. Sargis
View articletitled, The Paradox of Progress: Environmental Disruption of Metabolism and the Diabetes Epidemic
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Diabetes June 2011, Vol.60, 1838-1848. doi:https://doi.org/10.2337/db11-0153
Maternal Environment and the Transgenerational Cycle of Obesity and Diabetes
Dana Dabelea; Tessa Crume
View articletitled, Maternal Environment and the Transgenerational Cycle of Obesity and Diabetes
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Diabetes June 2011, Vol.60, 1849-1855. doi:https://doi.org/10.2337/db11-0400

Commentary

Insulin-Induced Hypoglycemia and Its Effect on the Brain: Unraveling Metabolism by In Vivo Nuclear Magnetic Resonance
Raimund I. Herzog; Robert S. Sherwin; Douglas L. Rothman
View articletitled, Insulin-Induced Hypoglycemia and Its Effect on the Brain<span class="subtitle-colon">: </span><span class="subtitle">Unraveling Metabolism by In Vivo Nuclear Magnetic Resonance</span>
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Diabetes June 2011, Vol.60, 1856-1858. doi:https://doi.org/10.2337/db11-0498
Epigenetics and Diabetes Risk: Not Just for Imprinting Anymore?
Toni I. Pollin
View articletitled, Epigenetics and Diabetes Risk: Not Just for Imprinting Anymore?
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Diabetes June 2011, Vol.60, 1859-1860. doi:https://doi.org/10.2337/db11-0515

Metabolism

Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity
Janne Prawitt; Mouaadh Abdelkarim; Johanna H.M. Stroeve; Iuliana Popescu; Helene Duez; Vidya R. Velagapudi; Julie Dumont; Emmanuel Bouchaert; Theo H. van Dijk; Anthony Lucas; Emilie Dorchies; Mehdi Daoudi; Sophie Lestavel; Frank J. Gonzalez; Matej Oresic; Bertrand Cariou; Folkert Kuipers; Sandrine Caron; Bart Staels
View articletitled, Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity
Supplementary data
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Diabetes June 2011, Vol.60, 1861-1871. doi:https://doi.org/10.2337/db11-0030
Suppression of FoxO1 Activity by Long-Chain Fatty Acyl Analogs
Ghadeer Zatara; Rachel Hertz; Maayan Shaked; Nina Mayorek; Etedal Morad; Etty Grad; Amos Cahan; Haim D. Danenberg; Terry G. Unterman; Jacob Bar-Tana
View articletitled, Suppression of FoxO1 Activity by Long-Chain Fatty Acyl Analogs
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Diabetes June 2011, Vol.60, 1872-1881. doi:https://doi.org/10.2337/db11-0248
Metabolic Remodeling of Human Skeletal Myocytes by Cocultured Adipocytes Depends on the Lipolytic State of the System
Jean-Paul Kovalik; Dorothy Slentz; Robert D. Stevens; William E. Kraus; Joseph A. Houmard; James B. Nicoll; Y. Renee Lea-Currie; Karen Everingham; C. Lawrence Kien; Benjamin M. Buehrer; Deborah M. Muoio
View articletitled, Metabolic Remodeling of Human Skeletal Myocytes by Cocultured Adipocytes Depends on the Lipolytic State of the System
Supplementary data
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Diabetes June 2011, Vol.60, 1882-1893. doi:https://doi.org/10.2337/db10-0427
Comparison of Dorsocervical With Abdominal Subcutaneous Adipose Tissue in Patients With and Without Antiretroviral Therapy–Associated Lipodystrophy
Ksenia Sevastianova; Jussi Sutinen; Dario Greco; Meline Sievers; Kaisa Salmenkivi; Julia Perttilä; Vesa M. Olkkonen; Dick Wågsäter; Martin E. Lidell; Sven Enerbäck; Per Eriksson; Ulrich A. Walker; Petri Auvinen; Matti Ristola; Hannele Yki-Järvinen
View articletitled, Comparison of Dorsocervical With Abdominal Subcutaneous Adipose Tissue in Patients With and Without Antiretroviral Therapy–Associated Lipodystrophy
Supplementary data
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Diabetes June 2011, Vol.60, 1894-1900. doi:https://doi.org/10.2337/db11-0075
Glucose Transporter-1 in the Hypothalamic Glial Cells Mediates Glucose Sensing to Regulate Glucose Production In Vivo
Madhu Chari; Clair S. Yang; Carol K.L. Lam; Katie Lee; Patricia Mighiu; Andrea Kokorovic; Grace W.C. Cheung; Teresa Y.Y. Lai; Penny Y.T. Wang; Tony K.T. Lam
View articletitled, Glucose Transporter-1 in the Hypothalamic Glial Cells Mediates Glucose Sensing to Regulate Glucose Production In Vivo
Supplementary data
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Diabetes June 2011, Vol.60, 1901-1906. doi:https://doi.org/10.2337/db11-0120

Signal Transduction

Klotho Depletion Contributes to Increased Inflammation in Kidney of the db/db Mouse Model of Diabetes via RelA (Serine)536 Phosphorylation
Yanhua Zhao; Srijita Banerjee; Nilay Dey; Wanda S. LeJeune; Partha S. Sarkar; Reynolds Brobey; Kevin P. Rosenblatt; Ronald G. Tilton; Sanjeev Choudhary
View articletitled, Klotho Depletion Contributes to Increased Inflammation in Kidney of the <em>db/db</em> Mouse Model of Diabetes via RelA (Serine)<sup>536</sup> Phosphorylation
Supplementary data
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Diabetes June 2011, Vol.60, 1907-1916. doi:https://doi.org/10.2337/db10-1262

Obesity Studies

Dipeptidyl Peptidase 4 Is a Novel Adipokine Potentially Linking Obesity to the Metabolic Syndrome
Daniela Lamers; Susanne Famulla; Nina Wronkowitz; Sonja Hartwig; Stefan Lehr; D. Margriet Ouwens; Kristin Eckardt; Jean M. Kaufman; Mikael Ryden; Stefan Müller; Franz-Georg Hanisch; Johannes Ruige; Peter Arner; Henrike Sell; Juergen Eckel
View articletitled, Dipeptidyl Peptidase 4 Is a Novel Adipokine Potentially Linking Obesity to the Metabolic Syndrome
Supplementary data
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Diabetes June 2011, Vol.60, 1917-1925. doi:https://doi.org/10.2337/db10-1707
Genetic Defect in Phospholipase Cδ1 Protects Mice From Obesity by Regulating Thermogenesis and Adipogenesis
Masayuki Hirata; Mutsumi Suzuki; Rika Ishii; Reiko Satow; Takafumi Uchida; Tomoya Kitazumi; Tsutomu Sasaki; Tadahiro Kitamura; Hideki Yamaguchi; Yoshikazu Nakamura; Kiyoko Fukami
View articletitled, Genetic Defect in Phospholipase Cδ1 Protects Mice From Obesity by Regulating Thermogenesis and Adipogenesis
Supplementary data
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Diabetes June 2011, Vol.60, 1926-1937. doi:https://doi.org/10.2337/db10-1500
Body Weight, Not Insulin Sensitivity or Secretion, May Predict Spontaneous Weight Changes in Nondiabetic and Prediabetic Subjects: The RISC Study
Eleni Rebelos; Elza Muscelli; Andrea Natali; Beverley Balkau; Geltrude Mingrone; Piermarco Piatti; Thomas Konrad; Andrea Mari; Ele Ferrannini; on behalf of the RISC Study Investigators
View articletitled, Body Weight, Not Insulin Sensitivity or Secretion, May Predict Spontaneous Weight Changes in Nondiabetic and Prediabetic Subjects<span class="subtitle-colon">: </span><span class="subtitle">The RISC Study</span>
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Diabetes June 2011, Vol.60, 1938-1945. doi:https://doi.org/10.2337/db11-0217

Islet Studies

Thrombospondin-1: An Islet Endothelial Cell Signal of Importance for β-Cell Function
Johan Olerud; Dariush Mokhtari; Magnus Johansson; Gustaf Christoffersson; Jack Lawler; Nils Welsh; Per-Ola Carlsson
View articletitled, Thrombospondin-1: An Islet Endothelial Cell Signal of Importance for β-Cell Function
Supplementary data
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Diabetes June 2011, Vol.60, 1946-1954. doi:https://doi.org/10.2337/db10-0277

Immunology and Transplantation

The Soluble CTLA-4 Splice Variant Protects From Type 1 Diabetes and Potentiates Regulatory T-Cell Function
Kay D. Gerold; Peilin Zheng; Daniel B. Rainbow; Alma Zernecke; Linda S. Wicker; Stephan Kissler
View articletitled, The Soluble CTLA-4 Splice Variant Protects From Type 1 Diabetes and Potentiates Regulatory T-Cell Function
Supplementary data
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Diabetes June 2011, Vol.60, 1955-1963. doi:https://doi.org/10.2337/db11-0130

Complications

Inhibition of Plasminogen Activator Inhibitor-1 Restores Skeletal Muscle Regeneration in Untreated Type 1 Diabetic Mice
Matthew P. Krause; Jasmin Moradi; Aliyah A. Nissar; Michael C. Riddell; Thomas J. Hawke
View articletitled, Inhibition of Plasminogen Activator Inhibitor-1 Restores Skeletal Muscle Regeneration in Untreated Type 1 Diabetic Mice
Supplementary data
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Diabetes June 2011, Vol.60, 1964-1972. doi:https://doi.org/10.2337/db11-0007
Glycation of LDL by Methylglyoxal Increases Arterial Atherogenicity: A Possible Contributor to Increased Risk of Cardiovascular Disease in Diabetes
Naila Rabbani; Lisa Godfrey; Mingzhan Xue; Fozia Shaheen; Michèle Geoffrion; Ross Milne; Paul J. Thornalley
View articletitled, Glycation of LDL by Methylglyoxal Increases Arterial Atherogenicity<span class="subtitle-colon">: </span><span class="subtitle">A Possible Contributor to Increased Risk of Cardiovascular Disease in Diabetes</span>
Supplementary data
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Diabetes June 2011, Vol.60, 1973-1980. doi:https://doi.org/10.2337/db11-0085
Transcriptional Profiling of Diabetic Neuropathy in the BKS db/db Mouse: A Model of Type 2 Diabetes
Manjusha Pande; Junguk Hur; Yu Hong; Carey Backus; John M. Hayes; Sang Su Oh; Matthias Kretzler; Eva L. Feldman
View articletitled, Transcriptional Profiling of Diabetic Neuropathy in the BKS <em>db/db</em> Mouse<span class="subtitle-colon">: </span><span class="subtitle">A Model of Type 2 Diabetes</span>
Supplementary data
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Diabetes June 2011, Vol.60, 1981-1989. doi:https://doi.org/10.2337/db10-1541

Pharmacology and Therapeutics

Activation of Peroxisome Proliferator–Activated Receptor-β/-δ (PPAR-β/-δ) Ameliorates Insulin Signaling and Reduces SOCS3 Levels by Inhibiting STAT3 in Interleukin-6–Stimulated Adipocytes
Lucía Serrano-Marco; Ricardo Rodríguez-Calvo; Ilhem El Kochairi; Xavier Palomer; Liliane Michalik; Walter Wahli; Manuel Vázquez-Carrera
View articletitled, Activation of Peroxisome Proliferator–Activated Receptor-β/-δ (PPAR-β/-δ) Ameliorates Insulin Signaling and Reduces SOCS3 Levels by Inhibiting STAT3 in Interleukin-6–Stimulated Adipocytes
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Diabetes June 2011, Vol.60, 1990-1999. doi:https://doi.org/10.2337/db10-0704

Genetics

Impaired Insulin Secretion and Enhanced Insulin Sensitivity in Cholecystokinin-Deficient Mice
Chun-Min Lo; Silvana Obici; H. Henry Dong; Michael Haas; Dawnwen Lou; Dae Hyun Kim; Min Liu; David D’Alessio; Stephen C. Woods; Patrick Tso
View articletitled, Impaired Insulin Secretion and Enhanced Insulin Sensitivity in Cholecystokinin-Deficient Mice
Supplementary data
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Diabetes June 2011, Vol.60, 2000-2007. doi:https://doi.org/10.2337/db10-0789

Erratum

Erratum
View articletitled, Erratum
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Diabetes June 2011, Vol.60, 2008. doi:https://doi.org/10.2337/db11-er07

Issues and Events

Issues and Events
View articletitled, Issues and Events
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Diabetes June 2011, Vol.60, 2009. doi:https://doi.org/10.2337/db11-ie07

Online Letters to the Editor

Comment on: Ferrannini. Learning From Glycosuria. Diabetes 2011;60:695–696
Robert C. Stanton
View articletitled, Comment on: Ferrannini. Learning From Glycosuria. Diabetes 2011;60:695–696
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Diabetes June 2011, Vol.60, e19. doi:https://doi.org/10.2337/db11-0483
Response to Comment on: Ferrannini. Learning From Glycosuria. Diabetes 2011;60:695–696
Ele Ferrannini
View articletitled, Response to Comment on: Ferrannini. Learning From Glycosuria. Diabetes 2011;60:695–696
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Diabetes June 2011, Vol.60, e20. doi:https://doi.org/10.2337/db11-0541
MRI Metrics of Cerebral Endothelial Cell–Derived Exosomes for the Treatment of Cognitive Dysfunction Induced in Aging Rats Subjected to Type 2 Diabetes
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
227-OR: Tirzepatide Reduces HbA1c and Body Weight Significantly More than Placebo Regardless of Insulin Sensitivity and Beta-Cell Function—Post Hoc Analysis from SURMOUNT-2
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