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Volume 60, Issue 8
August 2011
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ISSN 0012-1797
EISSN 1939-327X
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Perspectives in Diabetes

The Metabolically Benign and Malignant Fatty Liver
Norbert Stefan; Hans-Ulrich Häring
View articletitled, The Metabolically Benign and Malignant Fatty Liver
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Diabetes July 2011, Vol.60, 2011-2017. doi:https://doi.org/10.2337/db11-0231

Commentary

Sleeping Islets and the Relationship Between β-Cell Mass and Function
Gordon C. Weir; Susan Bonner-Weir
View articletitled, Sleeping Islets and the Relationship Between β-Cell Mass and Function
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Diabetes July 2011, Vol.60, 2018-2019. doi:https://doi.org/10.2337/db10-1808
To B or Not to B: (Anti)bodies of Evidence on the Crime Scene of Type 1 Diabetes?
Roberto Mallone; Vedran Brezar
View articletitled, To B or Not to B: (Anti)bodies of Evidence on the Crime Scene of Type 1 Diabetes?
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Diabetes July 2011, Vol.60, 2020-2022. doi:https://doi.org/10.2337/db11-0700

Metabolism

Macrophage Deletion of SOCS1 Increases Sensitivity to LPS and Palmitic Acid and Results in Systemic Inflammation and Hepatic Insulin Resistance
Nirupa Sachithanandan; Kate L. Graham; Sandra Galic; Jane E. Honeyman; Stacey L. Fynch; Kimberly A. Hewitt; Gregory R. Steinberg; Thomas W. Kay
View articletitled, Macrophage Deletion of SOCS1 Increases Sensitivity to LPS and Palmitic Acid and Results in Systemic Inflammation and Hepatic Insulin Resistance
Supplementary data
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Diabetes July 2011, Vol.60, 2023-2031. doi:https://doi.org/10.2337/db11-0259
Storage of Circulating Free Fatty Acid in Adipose Tissue of Postabsorptive Humans: Quantitative Measures and Implications for Body Fat Distribution
Christina Koutsari; Asem H. Ali; Manpreet S. Mundi; Michael D. Jensen
View articletitled, Storage of Circulating Free Fatty Acid in Adipose Tissue of Postabsorptive Humans<span class="subtitle-colon">: </span><span class="subtitle">Quantitative Measures and Implications for Body Fat Distribution</span>
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Diabetes July 2011, Vol.60, 2032-2040. doi:https://doi.org/10.2337/db11-0154
Severity of Diabetes Governs Vascular Lipoprotein Lipase by Affecting Enzyme Dimerization and Disassembly
Ying Wang; Prasanth Puthanveetil; Fang Wang; Min Suk Kim; Ashraf Abrahani; Brian Rodrigues
View articletitled, Severity of Diabetes Governs Vascular Lipoprotein Lipase by Affecting Enzyme Dimerization and Disassembly
Supplementary data
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Diabetes July 2011, Vol.60, 2041-2050. doi:https://doi.org/10.2337/db11-0042
Reduction in Reactive Oxygen Species Production by Mitochondria From Elderly Subjects With Normal and Impaired Glucose Tolerance
Sangeeta Ghosh; Raweewan Lertwattanarak; Natalie Lefort; Marjorie Molina-Carrion; Joaquin Joya-Galeana; Benjamin P. Bowen; Jose de Jesus Garduno-Garcia; Muhammad Abdul-Ghani; Arlan Richardson; Ralph A. DeFronzo; Lawrence Mandarino; Holly Van Remmen; Nicolas Musi
View articletitled, Reduction in Reactive Oxygen Species Production by Mitochondria From Elderly Subjects With Normal and Impaired Glucose Tolerance
Supplementary data
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Diabetes July 2011, Vol.60, 2051-2060. doi:https://doi.org/10.2337/db11-0121
Endothelin-1 Reduces Glucose Uptake in Human Skeletal Muscle In Vivo and In Vitro
Alexey Shemyakin; Firoozeh Salehzadeh; Daniella Esteves Duque-Guimaraes; Felix Böhm; Eric Rullman; Thomas Gustafsson; John Pernow; Anna Krook
View articletitled, Endothelin-1 Reduces Glucose Uptake in Human Skeletal Muscle In Vivo and In Vitro
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Diabetes July 2011, Vol.60, 2061-2067. doi:https://doi.org/10.2337/db10-1281
A Low-Oxygenated Subpopulation of Pancreatic Islets Constitutes a Functional Reserve of Endocrine Cells
Richard Olsson; Per-Ola Carlsson
View articletitled, A Low-Oxygenated Subpopulation of Pancreatic Islets Constitutes a Functional Reserve of Endocrine Cells
Supplementary data
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Diabetes July 2011, Vol.60, 2068-2075. doi:https://doi.org/10.2337/db09-0877

Islet Studies

Heterozygous Inactivation of the Na/Ca Exchanger Increases Glucose-Induced Insulin Release, β-Cell Proliferation, and Mass
Evrard Nguidjoe; Sophie Sokolow; Serge Bigabwa; Nathalie Pachera; Eva D'Amico; Florent Allagnat; Jean-Marie Vanderwinden; Abdullah Sener; Mario Manto; Marianne Depreter; Jan Mast; Geraldine Joanny; Eduard Montanya; Jacques Rahier; Alessandra K. Cardozo; Décio L. Eizirik; Stéphane Schurmans; André Herchuelz
View articletitled, Heterozygous Inactivation of the Na/Ca Exchanger Increases Glucose-Induced Insulin Release, β-Cell Proliferation, and Mass
Supplementary data
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Diabetes July 2011, Vol.60, 2076-2085. doi:https://doi.org/10.2337/db10-0924
Progressive Erosion of β-Cell Function Precedes the Onset of Hyperglycemia in the NOD Mouse Model of Type 1 Diabetes
Diego Ize-Ludlow; Yaima L. Lightfoot; Matthew Parker; Song Xue; Clive Wasserfall; Michael J. Haller; Desmond Schatz; Dorothy J. Becker; Mark A. Atkinson; Clayton E. Mathews
View articletitled, Progressive Erosion of β-Cell Function Precedes the Onset of Hyperglycemia in the NOD Mouse Model of Type 1 Diabetes
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Diabetes July 2011, Vol.60, 2086-2091. doi:https://doi.org/10.2337/db11-0373
In Vivo Misfolding of Proinsulin Below the Threshold of Frank Diabetes
Israel Hodish; Afaf Absood; Leanza Liu; Ming Liu; Leena Haataja; Dennis Larkin; Ahmed Al-Khafaji; Anthony Zaki; Peter Arvan
View articletitled, In Vivo Misfolding of Proinsulin Below the Threshold of Frank Diabetes
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Diabetes July 2011, Vol.60, 2092-2101. doi:https://doi.org/10.2337/db10-1671

Immunology and Transplantation

Anti-Islet Autoantibodies Trigger Autoimmune Diabetes in the Presence of an Increased Frequency of Islet-Reactive CD4 T Cells
Diego G. Silva; Stephen R. Daley; Jennifer Hogan; Sau K. Lee; Charis E. Teh; Daniel Y. Hu; Kong-Peng Lam; Christopher C. Goodnow; Carola G. Vinuesa
View articletitled, Anti-Islet Autoantibodies Trigger Autoimmune Diabetes in the Presence of an Increased Frequency of Islet-Reactive CD4 T Cells
Supplementary data
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Diabetes July 2011, Vol.60, 2102-2111. doi:https://doi.org/10.2337/db10-1344
Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated β-Cell Death
Sefina Arif; Fabrice Moore; Katherine Marks; Thomas Bouckenooghe; Colin M. Dayan; Raquel Planas; Marta Vives-Pi; Jake Powrie; Timothy Tree; Piero Marchetti; Guo Cai Huang; Esteban N. Gurzov; Ricardo Pujol-Borrell; Decio L. Eizirik; Mark Peakman
View articletitled, Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated β-Cell Death
Supplementary data
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Diabetes July 2011, Vol.60, 2112-2119. doi:https://doi.org/10.2337/db10-1643
Defective Differentiation of Regulatory FoxP3+ T Cells by Small-Intestinal Dendritic Cells in Patients With Type 1 Diabetes
Ester Badami; Chiara Sorini; Margherita Coccia; Vera Usuelli; Laura Molteni; Andrea Mario Bolla; Marina Scavini; Alberto Mariani; Cecile King; Emanuele Bosi; Marika Falcone
View articletitled, Defective Differentiation of Regulatory FoxP3<sup>+</sup> T Cells by Small-Intestinal Dendritic Cells in Patients With Type 1 Diabetes
Supplementary data
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Diabetes July 2011, Vol.60, 2120-2124. doi:https://doi.org/10.2337/db10-1201
Uncoupling of Proliferation and Cytokines From Suppression Within the CD4+CD25+Foxp3+ T–Cell Compartment in the 1st Year of Human Type 1 Diabetes
Angela Hughson; Irina Bromberg; Barbara Johnson; Sally Quataert; Nicholas Jospe; Deborah J. Fowell
View articletitled, Uncoupling of Proliferation and Cytokines From Suppression Within the CD4+CD25+Foxp3+ T–Cell Compartment in the 1st Year of Human Type 1 Diabetes
Supplementary data
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Diabetes July 2011, Vol.60, 2125-2133. doi:https://doi.org/10.2337/db10-1661
High-Fat Diet–Induced Adipocyte Cell Death Occurs Through a Cyclophilin D Intrinsic Signaling Pathway Independent of Adipose Tissue Inflammation
Daorong Feng; Yan Tang; Hyokjoon Kwon; Haihong Zong; Meredith Hawkins; Richard N. Kitsis; Jeffrey E. Pessin
View articletitled, High-Fat Diet–Induced Adipocyte Cell Death Occurs Through a Cyclophilin D Intrinsic Signaling Pathway Independent of Adipose Tissue Inflammation
Supplementary data
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Diabetes July 2011, Vol.60, 2134-2143. doi:https://doi.org/10.2337/db10-1411
Superoxide Production by Macrophages and T Cells Is Critical for the Induction of Autoreactivity and Type 1 Diabetes
Terri C. Thayer; Matthew Delano; Chao Liu; Jing Chen; Lindsey E. Padgett; Hubert M. Tse; Mani Annamali; Jon D. Piganelli; Lyle L. Moldawer; Clayton E. Mathews
View articletitled, Superoxide Production by Macrophages and T Cells Is Critical for the Induction of Autoreactivity and Type 1 Diabetes
Supplementary data
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Diabetes July 2011, Vol.60, 2144-2151. doi:https://doi.org/10.2337/db10-1222

Pathophysiology

Higher Cord C-Peptide Concentrations Are Associated With Slower Growth Rate in the 1st Year of Life in Girls but Not in Boys
Nolwenn Regnault; Jérémie Botton; Barbara Heude; Anne Forhan; Régis Hankard; Bernard Foliguet; Teresa A. Hillier; Jean-Claude Souberbielle; Patricia Dargent-Molina; Marie-Aline Charles; the EDEN Mother-Child Cohort Study Group
View articletitled, Higher Cord C-Peptide Concentrations Are Associated With Slower Growth Rate in the 1st Year of Life in Girls but Not in Boys
Supplementary data
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Diabetes July 2011, Vol.60, 2152-2159. doi:https://doi.org/10.2337/db10-1189
Loss of Inverse Relationship Between Pulsatile Insulin and Glucagon Secretion in Patients With Type 2 Diabetes
Björn A. Menge; Lena Grüber; Signe M. Jørgensen; Carolyn F. Deacon; Wolfgang E. Schmidt; Johannes D. Veldhuis; Jens J. Holst; Juris J. Meier
View articletitled, Loss of Inverse Relationship Between Pulsatile Insulin and Glucagon Secretion in Patients With Type 2 Diabetes
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Diabetes July 2011, Vol.60, 2160-2168. doi:https://doi.org/10.2337/db11-0251
The Insulin-Like Growth Factor-1 Receptor Is a Negative Regulator of Nitric Oxide Bioavailability and Insulin Sensitivity in the Endothelium
Afroze Abbas; Helen Imrie; Hema Viswambharan; Piruthivi Sukumar; Adil Rajwani; Richard M. Cubbon; Matthew Gage; Jessica Smith; Stacey Galloway; Nadira Yuldeshava; Matthew Kahn; Shouhong Xuan; Peter J. Grant; Keith M. Channon; David J. Beech; Stephen B. Wheatcroft; Mark T. Kearney
View articletitled, The Insulin-Like Growth Factor-1 Receptor Is a Negative Regulator of Nitric Oxide Bioavailability and Insulin Sensitivity in the Endothelium
Supplementary data
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Diabetes July 2011, Vol.60, 2169-2178. doi:https://doi.org/10.2337/db11-0197
CD14 Modulates Inflammation-Driven Insulin Resistance
José Manuel Fernández-Real; Sofia Pérez del Pulgar; Elodie Luche; José Maria Moreno-Navarrete; Aurelie Waget; Matteo Serino; Eleonora Sorianello; Alex Sánchez-Pla; Francesc Carmona Pontaque; Joan Vendrell; Matilde R. Chacón; Wifredo Ricart; Remy Burcelin; Antonio Zorzano
View articletitled, CD14 Modulates Inflammation-Driven Insulin Resistance
Supplementary data
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Diabetes July 2011, Vol.60, 2179-2186. doi:https://doi.org/10.2337/db10-1210

Complications

The RANKL/RANK/OPG Signaling Pathway Mediates Medial Arterial Calcification in Diabetic Charcot Neuroarthropathy
Agbor Ndip; Alfred Williams; Edward B. Jude; Ferdinand Serracino-Inglott; Steve Richardson; J.V. Smyth; Andrew J.M. Boulton; M. Yvonne Alexander
View articletitled, The RANKL/RANK/OPG Signaling Pathway Mediates Medial Arterial Calcification in Diabetic Charcot Neuroarthropathy
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Diabetes July 2011, Vol.60, 2187-2196. doi:https://doi.org/10.2337/db10-1220

Genetics

Novel Locus FER Is Associated With Serum HMW Adiponectin Levels
Lu Qi; Claudia Menzaghi; Lucia Salvemini; Concetta De Bonis; Vincenzo Trischitta; Frank B. Hu
View articletitled, Novel Locus <em>FER</em> Is Associated With Serum HMW Adiponectin Levels
Supplementary data
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Diabetes July 2011, Vol.60, 2197-2201. doi:https://doi.org/10.2337/db10-1645

Issues and Events

Issues and Events
View articletitled, Issues and Events
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Diabetes July 2011, Vol.60, 2202. doi:https://doi.org/10.2337/db11-ie08

Online Letters to the Editor

Comment on: Ott et al. Reduction in Basal Nitric Oxide Activity Causes Albuminuria. Diabetes 2011;60:572–576
Dimitrios Tsikas; Stefan Engeli; Jens Tank; Dirk O. Stichtenoth; Jens Jordan
View articletitled, Comment on: Ott et al. Reduction in Basal Nitric Oxide Activity Causes Albuminuria. Diabetes 2011;60:572–576
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Diabetes July 2011, Vol.60, e21. doi:https://doi.org/10.2337/db11-0519
Response to Comment on: Ott et al. Reduction in Basal Nitric Oxide Activity Causes Albuminuria. Diabetes 2011;60:572–576
Christian Ott; Markus P. Schneider; Roland E. Schmieder
View articletitled, Response to Comment on: Ott et al. Reduction in Basal Nitric Oxide Activity Causes Albuminuria. Diabetes 2011;60:572–576
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Diabetes July 2011, Vol.60, e22. doi:https://doi.org/10.2337/db11-0602
MRI Metrics of Cerebral Endothelial Cell–Derived Exosomes for the Treatment of Cognitive Dysfunction Induced in Aging Rats Subjected to Type 2 Diabetes
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
227-OR: Tirzepatide Reduces HbA1c and Body Weight Significantly More than Placebo Regardless of Insulin Sensitivity and Beta-Cell Function—Post Hoc Analysis from SURMOUNT-2
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