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Editorial

Changing of the Guards

K. Sreekumaran Nair

Extract

View articletitled, Changing of the Guards

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Topics: autologous chondrocyte implantation , christianity , consultants , insulin , metabolism

Diabetes December 2011, Vol.61, 1-3. doi:https://doi.org/10.2337/db11-1490

Banting Lecture

Banting Lecture 2011: Hyperinsulinemia: Cause or Consequence?

Barbara E. Corkey

Abstract

View articletitled, Banting Lecture 2011: Hyperinsulinemia: Cause or Consequence?

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Topics: bodily secretions , glucose , hyperinsulinism , insulin , insulin secretion

Diabetes December 2011, Vol.61, 4-13. doi:https://doi.org/10.2337/db11-1483

Perspectives in Diabetes

Central Role for Interleukin-2 in Type 1 Diabetes

Maigan A. Hulme; Clive H. Wasserfall; Mark A. Atkinson; Todd M. Brusko

Abstract

View articletitled, Central Role for Interleukin-2 in Type 1 Diabetes

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Topics: interleukin-2 , diabetes mellitus, type 1

Diabetes December 2011, Vol.61, 14-22. doi:https://doi.org/10.2337/db11-1213

Nutrient Sensing, Autophagy, and Diabetic Nephropathy

Shinji Kume; Merlin C. Thomas; Daisuke Koya

Extract

View articletitled, Nutrient Sensing, Autophagy, and Diabetic Nephropathy

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Topics: diabetic nephropathy , nutrients , autophagy , kidney

Diabetes December 2011, Vol.61, 23-29. doi:https://doi.org/10.2337/db11-0555

Juvenile Diabetes Research Foundation: Mission, Strategy, and Priorities

Richard A. Insel; Darlene C. Deecher; Jeffrey Brewer

Extract

View articletitled, Juvenile Diabetes Research Foundation: Mission, Strategy, and Priorities

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Topics: diabetes mellitus, type 1

Diabetes December 2011, Vol.61, 30-35. doi:https://doi.org/10.2337/db11-1398

Commentary

Why Are C-Section Deliveries Linked to Childhood Type 1 Diabetes?

Kendra Vehik; Dana Dabelea

Abstracts

View articletitled, Why Are C-Section Deliveries Linked to Childhood Type 1 Diabetes?

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Topics: cesarean section , child , diabetes mellitus, type 1

Diabetes December 2011, Vol.61, 36-37. doi:https://doi.org/10.2337/db11-1482

Publications Policy Update

Updates to Policies and Procedures Related to Potential Scientific and Academic Misconduct in the Journals of the American Diabetes Association

Christian S. Kohler; for the Publications Policy Committee of the American Diabetes Association

Abstracts

View articletitled, Updates to Policies and Procedures Related to Potential Scientific and Academic Misconduct in the Journals of the American Diabetes Association

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Topics: ethics , plagiarism , scientific misconduct , cellular biology , guidelines

Diabetes December 2011, Vol.61, 38-39. doi:https://doi.org/10.2337/db11-1432

Metabolism

Gipr Is Essential for Adrenocortical Steroidogenesis; However, Corticosterone Deficiency Does Not Mediate the Favorable Metabolic Phenotype of Gipr^−/− Mice

Holly E. Bates; Jonathan E. Campbell; John R. Ussher; Laurie L. Baggio; Adriano Maida; Yutaka Seino; Daniel J. Drucker

Abstract

View articletitled, Gipr Is Essential for Adrenocortical Steroidogenesis; However, Corticosterone Deficiency Does Not Mediate the Favorable Metabolic Phenotype of Gipr−/− Mice

Supplementary data

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Topics: corticosterone , mice , corticotropin , heart failure , adrenal glands

Diabetes December 2011, Vol.61, 40-48. doi:https://doi.org/10.2337/db11-1060

A Novel Mechanism for Regulating Hepatic Glycogen Synthesis Involving Serotonin and Cyclin-Dependent Kinase-5

Susan J. Tudhope; Chung-Chi Wang; John L. Petrie; Lloyd Potts; Fiona Malcomson; Julius Kieswich; Muhammad M. Yaqoob; Catherine Arden; Laura J. Hampson; Loranne Agius

Abstracts

View articletitled, A Novel Mechanism for Regulating Hepatic Glycogen Synthesis Involving Serotonin and Cyclin-Dependent Kinase-5

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Topics: agonists , cyclin-dependent kinase 5 , glycogen synthesis , hepatocytes , liver glycogen

Diabetes December 2011, Vol.61, 49-60. doi:https://doi.org/10.2337/db11-0870

Endoplasmic Reticulum Stress Inhibits STAT3-Dependent Suppression of Hepatic Gluconeogenesis via Dephosphorylation and Deacetylation

Kumi Kimura; Tomoko Yamada; Michihiro Matsumoto; Yoshiaki Kido; Tetsuya Hosooka; Shun-ichiro Asahara; Tomokazu Matsuda; Tsuguhito Ota; Hiroshi Watanabe; Yoshimichi Sai; Kenichi Miyamoto; Shuichi Kaneko; Masato Kasuga; Hiroshi Inoue

Abstract

View articletitled, Endoplasmic Reticulum Stress Inhibits STAT3-Dependent Suppression of Hepatic Gluconeogenesis via Dephosphorylation and Deacetylation

Supplementary data

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Topics: stat3 protein , stress , emergency service, hospital , psychological suppression , mice

Diabetes December 2011, Vol.61, 61-73. doi:https://doi.org/10.2337/db10-1684

Remodeling of Hepatic Metabolism and Hyperaminoacidemia in Mice Deficient in Proglucagon-Derived Peptides

Chika Watanabe; Yusuke Seino; Hiroki Miyahira; Michiyo Yamamoto; Ayako Fukami; Nobuaki Ozaki; Yoshiko Takagishi; Jun Sato; Tsutomu Fukuwatari; Katsumi Shibata; Yutaka Oiso; Yoshiharu Murata; Yoshitaka Hayashi

Abstract

View articletitled, Remodeling of Hepatic Metabolism and Hyperaminoacidemia in Mice Deficient in Proglucagon-Derived Peptides

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Topics: amino acids , glucagon , insulin , liver , mice

Diabetes December 2011, Vol.61, 74-84. doi:https://doi.org/10.2337/db11-0739

Hypothalamic Leucine Metabolism Regulates Liver Glucose Production

Ya Su; Tony K.T. Lam; Wu He; Alessandro Pocai; Joseph Bryan; Lydia Aguilar-Bryan; Roger Gutiérrez-Juárez

Abstracts

View articletitled, Hypothalamic Leucine Metabolism Regulates Liver Glucose Production

Supplementary data

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Topics: glucose , glucose homeostasis , leucine , metabolism , pancreas

Diabetes December 2011, Vol.61, 85-93. doi:https://doi.org/10.2337/db11-0857

Targeted Loss of GHR Signaling in Mouse Skeletal Muscle Protects Against High-Fat Diet–Induced Metabolic Deterioration

Archana Vijayakumar; YingJie Wu; Hui Sun; Xiaosong Li; Zuha Jeddy; Chengyu Liu; Gary J. Schwartz; Shoshana Yakar; Derek LeRoith

Abstracts

View articletitled, Targeted Loss of GHR Signaling in Mouse Skeletal Muscle Protects Against High-Fat Diet–Induced Metabolic Deterioration

Supplementary data

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Topics: mice , obesity , skeletal muscles , insulin

Diabetes December 2011, Vol.61, 94-103. doi:https://doi.org/10.2337/db11-0814

Signal Transduction

Hyperglycemia Enhances IGF-I–Stimulated Src Activation via Increasing Nox4-Derived Reactive Oxygen Species in a PKCζ-Dependent Manner in Vascular Smooth Muscle Cells

Gang Xi; Xinchun Shen; Laura A. Maile; Christine Wai; Katherine Gollahon; David R. Clemmons

Abstract

View articletitled, Hyperglycemia Enhances IGF-I–Stimulated Src Activation via Increasing Nox4-Derived Reactive Oxygen Species in a PKCζ-Dependent Manner in Vascular Smooth Muscle Cells

Supplementary data

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Topics: hyperglycemia , insulin-like growth factor i , nadph oxidase 4 , oxidation , glucose

Diabetes December 2011, Vol.61, 104-113. doi:https://doi.org/10.2337/db11-0990

Obesity Studies

Reproductive Tissues Maintain Insulin Sensitivity in Diet-Induced Obesity

Sheng Wu; Sara Divall; Fredric Wondisford; Andrew Wolfe

Abstract

View articletitled, Reproductive Tissues Maintain Insulin Sensitivity in Diet-Induced Obesity

Supplementary data

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Topics: insulin , mice , ovary , pituitary gland , signal transduction

Diabetes December 2011, Vol.61, 114-123. doi:https://doi.org/10.2337/db11-0956

Identification of BMP and Activin Membrane-Bound Inhibitor (BAMBI) as a Potent Negative Regulator of Adipogenesis and Modulator of Autocrine/Paracrine Adipogenic Factors

Xiao Luo; Louise J. Hutley; Julie A. Webster; Yu-Hee Kim; Dong-Fang Liu; Felicity S. Newell; Charlotte H. Widberg; Anthony Bachmann; Nigel Turner; Carsten Schmitz-Peiffer; Johannes B. Prins; Gong-She Yang; Jonathan P. Whitehead

Abstract

View articletitled, Identification of BMP and Activin Membrane-Bound Inhibitor (BAMBI) as a Potent Negative Regulator of Adipogenesis and Modulator of Autocrine/Paracrine Adipogenic Factors

Supplementary data

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Topics: aminosalicylic sodium , fibroblast growth factor 1 , p-aminosalicylic acid , pulmonary artery stenosis , simpson-golabi-behmel syndrome

Diabetes December 2011, Vol.61, 124-136. doi:https://doi.org/10.2337/db11-0998

In Vivo Adipogenesis in Rats Measured by Cell Kinetics in Adipocytes and Plastic-Adherent Stroma-Vascular Cells in Response to High-Fat Diet and Thiazolidinedione

Yourka D. Tchoukalova; Mark Fitch; Pamela M. Rogers; Jeffrey D. Covington; Tara M. Henagan; Jianping Ye; Marc K. Hellerstein; Eric Ravussin

Abstract

View articletitled, In Vivo Adipogenesis in Rats Measured by Cell Kinetics in Adipocytes and Plastic-Adherent Stroma-Vascular Cells in Response to High-Fat Diet and Thiazolidinedione

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Topics: adaptive support ventilation , adipocytes , automatic servo-ventilation , rats , sarcoma viruses, avian

Diabetes December 2012, Vol.61, 137-144. doi:https://doi.org/10.2337/db10-1768

Immunology and Transplantation

Synergistic Reversal of Type 1 Diabetes in NOD Mice With Anti-CD3 and Interleukin-1 Blockade: Evidence of Improved Immune Regulation

Vitaly Ablamunits; Octavian Henegariu; Jakob Bondo Hansen; Lynn Opare-Addo; Paula Preston-Hurlburt; Pere Santamaria; Thomas Mandrup-Poulsen; Kevan C. Herold

Abstract

View articletitled, Synergistic Reversal of Type 1 Diabetes in NOD Mice With Anti-CD3 and Interleukin-1 Blockade: Evidence of Improved Immune Regulation

Supplementary data

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Topics: interleukin-1 , mice , mice, inbred nod , monoclonal antibodies , pancreas

Diabetes December 2011, Vol.61, 145-154. doi:https://doi.org/10.2337/db11-1033

Inotuzumab Ozogamicin Murine Analog–Mediated B-Cell Depletion Reduces Anti-islet Allo- and Autoimmune Responses

Michele Carvello; Alessandra Petrelli; Andrea Vergani; Kang Mi Lee; Sara Tezza; Melissa Chin; Elena Orsenigo; Carlo Staudacher; Antonio Secchi; Kyri Dunussi-Joannopoulos; Mohamed H. Sayegh; James F. Markmann; Paolo Fiorina

Abstracts

View articletitled, Inotuzumab Ozogamicin Murine Analog–Mediated B-Cell Depletion Reduces Anti-islet Allo- and Autoimmune Responses

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Topics: allopurinol , b-lymphocytes , mice , inotuzumab ozogamicin , islets of langerhans transplantation

Diabetes December 2011, Vol.61, 155-165. doi:https://doi.org/10.2337/db11-0684

Cellular Mechanisms of Restored β-Cell Tolerance Mediated by Protective Alleles of Idd3 and Idd5

Emma E. Hamilton-Williams; Jocelyn Cheung; Daniel B. Rainbow; Kara M. Hunter; Linda S. Wicker; Linda A. Sherman

Abstracts

View articletitled, Cellular Mechanisms of Restored β-Cell Tolerance Mediated by Protective Alleles of Idd3 and Idd5

Supplementary data

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Topics: alleles , host (organism) , lymphocytes , mice , severe combined immunodeficiency

Diabetes December 2011, Vol.61, 166-174. doi:https://doi.org/10.2337/db11-0790

Maternal Serum Levels of 25-Hydroxy-Vitamin D During Pregnancy and Risk of Type 1 Diabetes in the Offspring

Ingvild M. Sørensen; Geir Joner; Pål A. Jenum; Anne Eskild; Peter A. Torjesen; Lars C. Stene

Abstract

View articletitled, Maternal Serum Levels of 25-Hydroxy-Vitamin D During Pregnancy and Risk of Type 1 Diabetes in the Offspring

Supplementary data

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Topics: child , diabetes mellitus, type 1 , pregnancy , vitamins , vitamin d

Diabetes December 2011, Vol.61, 175-178. doi:https://doi.org/10.2337/db11-0875

Distinguishing Persistent Insulin Autoantibodies With Differential Risk: Nonradioactive Bivalent Proinsulin/Insulin Autoantibody Assay

Liping Yu; Dongmei Miao; Laura Scrimgeour; Kelly Johnson; Marian Rewers; George S. Eisenbarth

Abstract

View articletitled, Distinguishing Persistent Insulin Autoantibodies With Differential Risk: Nonradioactive Bivalent Proinsulin/Insulin Autoantibody Assay

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Topics: autoantibodies , child , insulin , proinsulin , radiometry

Diabetes December 2011, Vol.61, 179-186. doi:https://doi.org/10.2337/db11-0670

Pathophysiology

Na⁺-d-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion

Abstract

View articletitled, Na+-d-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion

Supplementary data

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Topics: glucose , mice

Diabetes December 2011, Vol.61, 187-196. doi:https://doi.org/10.2337/db11-1029

Complications

Somatostatin Receptor Type 2 Antagonism Improves Glucagon and Corticosterone Counterregulatory Responses to Hypoglycemia in Streptozotocin-Induced Diabetic Rats

Jessica T.Y. Yue; Elena Burdett; David H. Coy; Adria Giacca; Suad Efendic; Mladen Vranic

Abstract

View articletitled, Somatostatin Receptor Type 2 Antagonism Improves Glucagon and Corticosterone Counterregulatory Responses to Hypoglycemia in Streptozotocin-Induced Diabetic Rats

Supplementary data

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Topics: corticosterone , glucagon , hypoglycemia , rats , insulin

Diabetes December 2011, Vol.61, 197-207. doi:https://doi.org/10.2337/db11-0690

Heparanase Is Essential for the Development of Diabetic Nephropathy in Mice

Natali Gil; Rachel Goldberg; Tzahi Neuman; Marjolein Garsen; Eyal Zcharia; Ariel M. Rubinstein; Toin van Kuppevelt; Amichay Meirovitz; Claudio Pisano; Jin-Ping Li; Johan van der Vlag; Israel Vlodavsky; Michael Elkin

Abstracts

View articletitled, Heparanase Is Essential for the Development of Diabetic Nephropathy in Mice

Supplementary data

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Topics: antibodies , diabetic nephropathy , kidney , mice , streptozocin

Diabetes December 2011, Vol.61, 208-216. doi:https://doi.org/10.2337/db11-1024

Sirtuin 1–Mediated Cellular Metabolic Memory of High Glucose Via the LKB1/AMPK/ROS Pathway and Therapeutic Effects of Metformin

Zhi Zheng; Haibing Chen; Jun Li; Tao Li; Bingqing Zheng; Ying Zheng; Huiyi Jin; Ying He; Qing Gu; Xun Xu

Abstract

View articletitled, Sirtuin 1–Mediated Cellular Metabolic Memory of High Glucose Via the LKB1/AMPK/ROS Pathway and Therapeutic Effects of Metformin

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Topics: ampk , glucose , hyperglycemia , memory , metformin

Diabetes December 2011, Vol.61, 217-228. doi:https://doi.org/10.2337/db11-0416

Pharmacology and Therapeutics

Nerve Growth Factor Gene Therapy Using Adeno-Associated Viral Vectors Prevents Cardiomyopathy in Type 1 Diabetic Mice

Marco Meloni; Betty Descamps; Andrea Caporali; Lorena Zentilin; Ilaria Floris; Mauro Giacca; Costanza Emanueli

Abstract

View articletitled, Nerve Growth Factor Gene Therapy Using Adeno-Associated Viral Vectors Prevents Cardiomyopathy in Type 1 Diabetic Mice

Supplementary data

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Topics: gene transfer techniques , heart , mice , spatial vectors , gene therapy

Diabetes December 2011, Vol.61, 229-240. doi:https://doi.org/10.2337/db11-0763

Genetics / Genomes / Proteomics / Metabolomics

The ATP-Sensitive K⁺ Channel ABCC8 S1369A Type 2 Diabetes Risk Variant Increases MgATPase Activity

Mohammad Fatehi; Mobeen Raja; Christian Carter; Daniel Soliman; Andrew Holt; Peter E. Light

Abstract

View articletitled, The ATP-Sensitive K+ Channel ABCC8 S1369A Type 2 Diabetes Risk Variant Increases MgATPase Activity

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Topics: abcc8 gene , diabetes mellitus, type 2 , haplotypes , mutation , kcnj11 gene

Diabetes December 2011, Vol.61, 241-249. doi:https://doi.org/10.2337/db11-0371

Greater Impact of Melanocortin-4 Receptor Deficiency on Rates of Growth and Risk of Type 2 Diabetes During Childhood Compared With Adulthood in Pima Indians

Marie S. Thearle; Yunhua L. Muller; Robert L. Hanson; Meghan Mullins; Maryam AbdusSamad; John Tran; William C. Knowler; Clifton Bogardus; Jonathan Krakoff; Leslie J. Baier

Abstract

View articletitled, Greater Impact of Melanocortin-4 Receptor Deficiency on Rates of Growth and Risk of Type 2 Diabetes During Childhood Compared With Adulthood in Pima Indians

Supplementary data

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Topics: body mass index procedure , child , diabetes mellitus, type 2 , mutation , obesity

Diabetes December 2011, Vol.61, 250-257. doi:https://doi.org/10.2337/db11-0708

Relative Expression of a Dominant Mutated ABCC8 Allele Determines the Clinical Manifestation of Congenital Hyperinsulinism

Ruth Shemer; Carmit Avnon Ziv; Efrat Laiba; Qing Zhou; Joel Gay; Sharona Tunovsky-Babaey; Show-Ling Shyng; Benjamin Glaser; David H. Zangen

Abstract

View articletitled, Relative Expression of a Dominant Mutated ABCC8 Allele Determines the Clinical Manifestation of Congenital Hyperinsulinism

Supplementary data

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Topics: abcc8 gene , alleles , congenital hyperinsulinism , dna , methylation

Diabetes December 2011, Vol.61, 258-263. doi:https://doi.org/10.2337/db11-0984

Issues and Events

Extract

View articletitled, Issues and Events

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Topics: circadian clocks , cocos nucifera , florida , metabolic diseases , wisconsin

Diabetes December 2011, Vol.61, 264. doi:https://doi.org/10.2337/db12-ie01

Online Letters to the Editor

Comment on: Maruthur et al. Does Genetic Ancestry Explain Higher Values of Glycated Hemoglobin in African Americans? Diabetes 2011;60:2434–2438

Samuel Dagogo-Jack

Extract

View articletitled, Comment on: Maruthur et al. Does Genetic Ancestry Explain Higher Values of Glycated Hemoglobin in African Americans? Diabetes 2011;60:2434–2438

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Topics: genetics , hemoglobin , hemoglobin a, glycosylated

Diabetes December 2011, Vol.61, e1. doi:https://doi.org/10.2337/db11-1277

Response to Comment on: Maruthur et al. Does Genetic Ancestry Explain Higher Values of Glycated Hemoglobin in African Americans? Diabetes 2011;60:2434–2438

Nisa M. Maruthur; W.H. Linda Kao; Elizabeth Selvin

Extract

View articletitled, Response to Comment on: Maruthur et al. Does Genetic Ancestry Explain Higher Values of Glycated Hemoglobin in African Americans? Diabetes 2011;60:2434–2438

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Topics: genetics , hemoglobin , hemoglobin a, glycosylated , glucose

Diabetes December 2011, Vol.61, e2. doi:https://doi.org/10.2337/db11-1379

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Banting Lecture

Perspectives in Diabetes

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Publications Policy Update

Metabolism

Signal Transduction

Obesity Studies

Immunology and Transplantation

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Genetics / Genomes / Proteomics / Metabolomics

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